LCE2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is one of the at least 20 genes expressed during epidermal differentiation and located on chromosomal band 1q21. This gene is involved in epidermal differentiation, and it is expressed at high levels in normal and psoriatic skin, but not in cultured keratinocytes or in any other tested cell types or tissues. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1water homeostasis (GO:0030104)9.76103767
2keratinocyte proliferation (GO:0043616)9.69353963
3hair cycle (GO:0042633)8.79151156
4molting cycle (GO:0042303)8.79151156
5peptide cross-linking (GO:0018149)8.78692062
6epidermal cell differentiation (GO:0009913)8.75085736
7long-chain fatty acid biosynthetic process (GO:0042759)8.24876752
8* epidermis development (GO:0008544)7.20408608
9linoleic acid metabolic process (GO:0043651)7.07465339
10bundle of His cell to Purkinje myocyte communication (GO:0086069)6.95618853
11lipoxygenase pathway (GO:0019372)6.79128962
12skin morphogenesis (GO:0043589)6.63011458
13intermediate filament organization (GO:0045109)6.46530741
14detection of bacterium (GO:0016045)6.10931125
15phosphatidylinositol acyl-chain remodeling (GO:0036149)5.79767701
16phosphatidylserine acyl-chain remodeling (GO:0036150)5.75188609
17detection of other organism (GO:0098543)5.57393218
18intermediate filament cytoskeleton organization (GO:0045104)5.11111003
19intermediate filament-based process (GO:0045103)4.95085238
20hemidesmosome assembly (GO:0031581)4.86112752
21keratinocyte development (GO:0003334)4.83062601
22regulation of natural killer cell differentiation (GO:0032823)4.69334718
23phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.61277724
24phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.42642440
25surfactant homeostasis (GO:0043129)4.37741002
26negative regulation of interferon-gamma production (GO:0032689)4.24507242
27phosphatidylcholine acyl-chain remodeling (GO:0036151)4.09096261
28establishment of tissue polarity (GO:0007164)4.05224360
29establishment of planar polarity (GO:0001736)4.05224360
30lateral sprouting from an epithelium (GO:0060601)4.02312284
31fatty acid elongation (GO:0030497)3.95820415
32epithelial cell differentiation involved in prostate gland development (GO:0060742)3.82517179
33polarized epithelial cell differentiation (GO:0030859)3.79122098
34chemical homeostasis within a tissue (GO:0048875)3.76170420
35ceramide biosynthetic process (GO:0046513)3.75797359
36ectoderm development (GO:0007398)3.75687742
37gap junction assembly (GO:0016264)3.67961772
38phosphatidylserine metabolic process (GO:0006658)3.54108074
39regulation of keratinocyte differentiation (GO:0045616)3.51479386
40* epithelium development (GO:0060429)3.43975903
41negative regulation of keratinocyte proliferation (GO:0010839)3.36286379
42positive regulation of epidermal cell differentiation (GO:0045606)3.29691842
43phospholipid efflux (GO:0033700)3.27438278
44positive regulation of cholesterol efflux (GO:0010875)3.24381184
45detection of external biotic stimulus (GO:0098581)3.13247082
46hair follicle morphogenesis (GO:0031069)3.07912223
47phospholipid catabolic process (GO:0009395)3.00807621
48positive regulation of epidermis development (GO:0045684)3.00770356
49* keratinization (GO:0031424)26.0963916
50establishment of skin barrier (GO:0061436)21.5831266
51regulation of keratinocyte proliferation (GO:0010837)2.93927287
52one-carbon compound transport (GO:0019755)2.89337945
53alditol phosphate metabolic process (GO:0052646)2.83131097
54positive regulation of sterol transport (GO:0032373)2.81185626
55positive regulation of cholesterol transport (GO:0032376)2.81185626
56negative regulation of interleukin-17 production (GO:0032700)2.79775838
57positive regulation of monocyte chemotaxis (GO:0090026)2.78338956
58regulation of epidermal cell differentiation (GO:0045604)2.74879429
59regulation of epidermis development (GO:0045682)2.72170509
60polyol transport (GO:0015791)2.72044699
61defense response to fungus (GO:0050832)2.66634349
62detection of biotic stimulus (GO:0009595)2.65777981
63ventricular cardiac muscle cell action potential (GO:0086005)2.65166207
64positive regulation of keratinocyte differentiation (GO:0045618)2.63591345
65skin development (GO:0043588)2.63377123
66sphingolipid biosynthetic process (GO:0030148)2.59446259
67eyelid development in camera-type eye (GO:0061029)2.56304948
68planar cell polarity pathway involved in neural tube closure (GO:0090179)2.51406687
69phosphatidylglycerol metabolic process (GO:0046471)2.45924116
70regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.44639220
71regulation of transforming growth factor beta1 production (GO:0032908)2.44274607
72regulation of cholesterol homeostasis (GO:2000188)2.44152958
73molting cycle process (GO:0022404)2.42587725
74hair cycle process (GO:0022405)2.42587725
75regulation of protein localization to cell surface (GO:2000008)2.42472326
76regulation of neuron projection regeneration (GO:0070570)2.39853101
77regulation of axon regeneration (GO:0048679)2.39853101
78unsaturated fatty acid biosynthetic process (GO:0006636)2.39330901
79epithelial cell differentiation (GO:0030855)2.39225168
80epithelial cell proliferation (GO:0050673)2.38829315
81response to phenylpropanoid (GO:0080184)2.37068071
82retinol metabolic process (GO:0042572)2.36670860
83epithelial cell-cell adhesion (GO:0090136)2.33201897
84regulation of natural killer cell activation (GO:0032814)2.32989599
85atrioventricular valve morphogenesis (GO:0003181)2.32787896
86intestinal epithelial cell development (GO:0060576)2.31026236
87regulation of T cell chemotaxis (GO:0010819)2.30328882
88positive regulation of T cell chemotaxis (GO:0010820)2.30328882
89regulation of heart rate by cardiac conduction (GO:0086091)2.29934009
90cellular response to antibiotic (GO:0071236)2.27277952
91fibrinolysis (GO:0042730)2.27018306
92cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.23005370
93cell communication involved in cardiac conduction (GO:0086065)2.13597606
94regulation of monocyte chemotaxis (GO:0090025)2.11687957
95sequestering of metal ion (GO:0051238)2.09350570
96defense response to Gram-negative bacterium (GO:0050829)2.09137609
97regulation of water loss via skin (GO:0033561)18.4716573
98desmosome organization (GO:0002934)13.3518942
99multicellular organismal water homeostasis (GO:0050891)11.7341933
100keratinocyte differentiation (GO:0030216)11.2350311

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.70385117
2P63_26484246_Chip-Seq_KERATINOCYTES_Human4.30590892
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.86985526
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.66790364
5SOX9_24532713_ChIP-Seq_HFSC_Mouse2.64473969
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.55317274
7HIF1A_21447827_ChIP-Seq_MCF-7_Human2.36845431
8SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.20920121
9SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.20920121
10TP63_23658742_ChIP-Seq_EP156T_Human2.18269012
11RXR_22108803_ChIP-Seq_LS180_Human2.07583407
12TP63_17297297_ChIP-ChIP_HaCaT_Human13.9050688
13ESR1_21235772_ChIP-Seq_MCF-7_Human1.99129585
14TP63_22573176_ChIP-Seq_HFKS_Human1.91932237
15ESR2_21235772_ChIP-Seq_MCF-7_Human1.91302636
16FOXO3_23340844_ChIP-Seq_DLD1_Human1.79177983
17GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.71227670
18ZNF217_24962896_ChIP-Seq_MCF-7_Human1.67944900
19TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.64751945
20EGR1_19032775_ChIP-ChIP_M12_Human1.54721485
21GATA6_21074721_ChIP-Seq_CACO-2_Human1.48685152
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.43014850
23ZNF263_19887448_ChIP-Seq_K562_Human1.36422668
24CTCF_27219007_Chip-Seq_Bcells_Human1.33405681
25KLF5_25053715_ChIP-Seq_YYC3_Human1.29248694
26AR_21572438_ChIP-Seq_LNCaP_Human1.26061758
27UBF1/2_26484160_Chip-Seq_HMECs_Human1.24861375
28GATA3_24758297_ChIP-Seq_MCF-7_Human1.23338071
29KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21784747
30TCF4_18268006_ChIP-ChIP_LS174T_Human1.15860388
31VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.15737751
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13438007
33RUNX1_27514584_Chip-Seq_MCF-7_Human1.12946218
34ESR1_20079471_ChIP-ChIP_T-47D_Human1.12600420
35ERG_20517297_ChIP-Seq_VCAP_Human1.12365116
36ATF3_27146783_Chip-Seq_COLON_Human1.09985485
37RACK7_27058665_Chip-Seq_MCF-7_Human1.06575587
38BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.05149709
39SOX2_20726797_ChIP-Seq_SW620_Human1.04542222
40ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03396706
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03214500
42KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01671719
43CJUN_26792858_Chip-Seq_BT549_Human1.00965422
44FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.99656201
45AHR_22903824_ChIP-Seq_MCF-7_Human0.99617304
46BCOR_27268052_Chip-Seq_Bcells_Human0.98098664
47CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96713439
48E2F1_20622854_ChIP-Seq_HELA_Human0.96305263
49DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96001116
50SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95081133
51CTCF_20526341_ChIP-Seq_ESCs_Human0.94880075
52UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94379934
53STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94242876
54FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.93500062
55FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.92315550
56SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.90977673
57AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.90738077
58TP53_18474530_ChIP-ChIP_U2OS_Human0.89364430
59TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.87732490
60SMC4_20622854_ChIP-Seq_HELA_Human0.85205206
61HNFA_21074721_ChIP-Seq_CACO-2_Human0.83793384
62CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.82079133
63CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.81621479
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80601330
65GATA4_25053715_ChIP-Seq_YYC3_Human0.79552339
66ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.79423957
67JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78993429
68CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.78957668
69GATA6_25053715_ChIP-Seq_YYC3_Human0.78842402
70SMAD4_21741376_ChIP-Seq_ESCs_Human0.78040968
71PPAR_26484153_Chip-Seq_NCI-H1993_Human0.77629924
72GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.77492720
73* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.76922469
74RBPJ_21746931_ChIP-Seq_IB4_Human0.76864327
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.76343784
76NRF2_20460467_ChIP-Seq_MEFs_Mouse0.76343784
77* P53_21459846_ChIP-Seq_SAOS-2_Human0.75783397
78SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.75230223
79CLOCK_20551151_ChIP-Seq_293T_Human0.75041740
80ARNT_22903824_ChIP-Seq_MCF-7_Human0.74510272
81BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.73110514
82FOXM1_26456572_ChIP-Seq_MCF-7_Human0.71845335
83TAF2_19829295_ChIP-Seq_ESCs_Human0.70082135
84LXR_22292898_ChIP-Seq_THP-1_Human0.68417018
85PIAS1_25552417_ChIP-Seq_VCAP_Human0.68170737
86PPARA_22158963_ChIP-Seq_LIVER_Mouse0.66848884
87Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.66756580
88P68_20966046_ChIP-Seq_HELA_Human0.65792426
89PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.65312291
90TBX20_22080862_ChIP-Seq_HEART_Mouse0.65192361
91TBX20_22328084_ChIP-Seq_HEART_Mouse0.65192361
92KDM2B_26808549_Chip-Seq_K562_Human0.65041584
93TP53_16413492_ChIP-PET_HCT116_Human0.64686851
94TCF4_22108803_ChIP-Seq_LS180_Human0.63917976
95FOXA1_25552417_ChIP-Seq_VCAP_Human0.63793946
96SA1_27219007_Chip-Seq_ERYTHROID_Human0.63682422
97RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.63034971
98P53_22127205_ChIP-Seq_FIBROBLAST_Human0.62864032
99GATA2_19941826_ChIP-Seq_K562_Human0.62518928
100ELK3_25401928_ChIP-Seq_HUVEC_Human0.62273334

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier9.93741087
2MP0005275_abnormal_skin_tensile7.62101709
3MP0005501_abnormal_skin_physiology5.48318959
4MP0010234_abnormal_vibrissa_follicle4.89487116
5MP0009379_abnormal_foot_pigmentation4.83299877
6MP0000579_abnormal_nail_morphology4.37504788
7MP0003941_abnormal_skin_development3.47660625
8MP0001216_abnormal_epidermal_layer3.25814195
9MP0003453_abnormal_keratinocyte_physiol3.02165649
10MP0004947_skin_inflammation2.86691486
11MP0004381_abnormal_hair_follicle2.84044002
12MP0010771_integument_phenotype2.81665179
13MP0002060_abnormal_skin_morphology2.56017216
14MP0001188_hyperpigmentation2.54999900
15MP0010678_abnormal_skin_adnexa2.53210324
16MP0000383_abnormal_hair_follicle2.39759251
17MP0000566_synostosis2.25347075
18MP0000377_abnormal_hair_follicle2.22778041
19MP0003191_abnormal_cellular_cholesterol2.19575588
20MP0002098_abnormal_vibrissa_morphology2.14435434
21MP0003705_abnormal_hypodermis_morpholog2.00113175
22MP0005409_darkened_coat_color1.95057684
23MP0000647_abnormal_sebaceous_gland1.90949057
24MP0002095_abnormal_skin_pigmentation1.90842262
25MP0009931_abnormal_skin_appearance1.79141484
26MP0000015_abnormal_ear_pigmentation1.78182629
27MP0004782_abnormal_surfactant_physiolog1.77021656
28MP0000467_abnormal_esophagus_morphology1.67651929
29MP0005174_abnormal_tail_pigmentation1.66726424
30MP0003011_delayed_dark_adaptation1.65217965
31MP0004885_abnormal_endolymph1.58209650
32MP0003878_abnormal_ear_physiology1.54282956
33MP0005377_hearing/vestibular/ear_phenot1.54282956
34MP0001191_abnormal_skin_condition1.45990929
35MP0000367_abnormal_coat/_hair1.32374304
36MP0000427_abnormal_hair_cycle1.28206494
37MP0003566_abnormal_cell_adhesion1.27766282
38MP0000465_gastrointestinal_hemorrhage1.11891742
39MP0000762_abnormal_tongue_morphology1.02086394
40MP0001243_abnormal_dermal_layer0.93424532
41MP0010352_gastrointestinal_tract_polyps0.92981087
42MP0002177_abnormal_outer_ear0.90874218
43MP0001784_abnormal_fluid_regulation0.87983636
44MP0004264_abnormal_extraembryonic_tissu0.83899287
45MP0005023_abnormal_wound_healing0.79760771
46MP0009053_abnormal_anal_canal0.78666503
47MP0001851_eye_inflammation0.77892537
48MP0005075_abnormal_melanosome_morpholog0.76732815
49MP0001984_abnormal_olfaction0.58087770
50MP0009780_abnormal_chondrocyte_physiolo0.57786449
51MP0002234_abnormal_pharynx_morphology0.55441650
52MP0010030_abnormal_orbit_morphology0.51951081
53MP0002009_preneoplasia0.51192765
54MP0003763_abnormal_thymus_physiology0.46052095
55MP0001340_abnormal_eyelid_morphology0.44630398
56MP0004185_abnormal_adipocyte_glucose0.43743298
57MP0009333_abnormal_splenocyte_physiolog0.39721949
58MP0005171_absent_coat_pigmentation0.39175632
59MP0008789_abnormal_olfactory_epithelium0.38264349
60MP0005257_abnormal_intraocular_pressure0.34249540
61MP0005394_taste/olfaction_phenotype0.33903360
62MP0005499_abnormal_olfactory_system0.33903360
63MP0003638_abnormal_response/metabolism_0.33549449
64MP0003315_abnormal_perineum_morphology0.32458233
65MP0002111_abnormal_tail_morphology0.30779544
66MP0001177_atelectasis0.30656246
67MP0001186_pigmentation_phenotype0.30616849
68MP0003950_abnormal_plasma_membrane0.30109149
69MP0005388_respiratory_system_phenotype0.30001926
70MP0002133_abnormal_respiratory_system0.30001926
71MP0000627_abnormal_mammary_gland0.29163322
72MP0000569_abnormal_digit_pigmentation0.27737632
73MP0002877_abnormal_melanocyte_morpholog0.26037575
74MP0005503_abnormal_tendon_morphology0.25048378
75MP0002282_abnormal_trachea_morphology0.23522956
76MP0005076_abnormal_cell_differentiation0.23259127
77MP0000685_abnormal_immune_system0.21911661
78MP0003300_gastrointestinal_ulcer0.21070997
79MP0002233_abnormal_nose_morphology0.19968241
80MP0008004_abnormal_stomach_pH0.19135846
81MP0000372_irregular_coat_pigmentation0.17805140
82MP0003755_abnormal_palate_morphology0.17767357
83MP0000428_abnormal_craniofacial_morphol0.17541279
84MP0004197_abnormal_fetal_growth/weight/0.16263164
85MP0002006_tumorigenesis0.15024738
86MP0009672_abnormal_birth_weight0.14935002
87MP0008438_abnormal_cutaneous_collagen0.14362990
88MP0002697_abnormal_eye_size0.14240167
89MP0002138_abnormal_hepatobiliary_system0.13862107
90MP0001958_emphysema0.13817271
91MP0005647_abnormal_sex_gland0.13120460
92MP0005193_abnormal_anterior_eye0.12587836
93MP0005666_abnormal_adipose_tissue0.12550049
94MP0001299_abnormal_eye_distance/0.12128631
95MP0002166_altered_tumor_susceptibility0.12111544
96MP0000462_abnormal_digestive_system0.11841557
97MP0000432_abnormal_head_morphology0.11367129
98MP0008569_lethality_at_weaning0.10559553
99MP0002075_abnormal_coat/hair_pigmentati0.10305201
100MP0005508_abnormal_skeleton_morphology0.10050136

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)9.57339273
2Palmoplantar hyperkeratosis (HP:0000972)8.39975680
3Congenital ichthyosiform erythroderma (HP:0007431)8.32566191
4Erythroderma (HP:0001019)8.10630995
5Palmar hyperkeratosis (HP:0010765)7.99615955
6Congenital nonbullous ichthyosiform erythroderma (HP:0007479)7.71353414
7Hypotrichosis (HP:0001006)6.97295196
8Plantar hyperkeratosis (HP:0007556)6.89580525
9Erythema (HP:0010783)6.78526471
10Alopecia of scalp (HP:0002293)6.30915453
11Onycholysis (HP:0001806)6.16843003
12Abnormality of the axillary hair (HP:0100134)6.01059490
13Abnormality of secondary sexual hair (HP:0009888)6.01059490
14Thick nail (HP:0001805)5.94027339
15Parakeratosis (HP:0001036)5.54375710
16Corneal erosion (HP:0200020)5.48172840
17Conjunctival hamartoma (HP:0100780)5.24598281
18Oral leukoplakia (HP:0002745)4.67413118
19Woolly hair (HP:0002224)4.62826646
20Palmoplantar keratoderma (HP:0000982)4.56254760
21Right ventricular cardiomyopathy (HP:0011663)4.38128810
22Gangrene (HP:0100758)4.34856431
23Hypohidrosis (HP:0000966)4.03807968
24Ectropion (HP:0000656)3.98605384
25Fragile nails (HP:0001808)3.98307583
26Eczematoid dermatitis (HP:0000976)3.77294850
27Abnormal blistering of the skin (HP:0008066)3.67493705
28Hamartoma of the eye (HP:0010568)3.52741270
29Sparse eyelashes (HP:0000653)3.48026091
30Nail dystrophy (HP:0008404)3.42557833
31Absent eyelashes (HP:0000561)3.37625992
32Lip pit (HP:0100267)3.33027536
33Abnormality of the salivary glands (HP:0010286)3.32246492
34Sparse scalp hair (HP:0002209)3.12433292
35Pruritus (HP:0000989)3.05616457
36Pili torti (HP:0003777)2.90629065
37Abnormal hair laboratory examination (HP:0003328)2.88369117
38Absent hair (HP:0002298)2.84646541
39Follicular hyperkeratosis (HP:0007502)2.64403747
40Lack of skin elasticity (HP:0100679)2.46631326
41Hypergammaglobulinemia (HP:0010702)2.42336586
42Blepharitis (HP:0000498)2.39197405
43Hypoplastic labia majora (HP:0000059)2.35874474
44Natal tooth (HP:0000695)2.34593431
45Milia (HP:0001056)2.27689773
46Furrowed tongue (HP:0000221)2.21833799
47Melanocytic nevus (HP:0000995)2.21140800
48Split foot (HP:0001839)2.17092037
49Abnormality of the labia majora (HP:0012881)2.14798888
50Slow-growing hair (HP:0002217)2.13071664
51Abnormality of hair growth rate (HP:0011363)2.13071664
52Advanced eruption of teeth (HP:0006288)2.11009934
53Selective tooth agenesis (HP:0001592)2.10626715
54Hyperhidrosis (HP:0000975)2.09999277
55Ridged nail (HP:0001807)2.07952962
56Abnormality of nail color (HP:0100643)10.3381624
57Pustule (HP:0200039)1.99742369
58Hamartoma (HP:0010566)1.99304924
59Conical tooth (HP:0000698)1.95802640
60Nasolacrimal duct obstruction (HP:0000579)1.95761312
61Laryngomalacia (HP:0001601)1.95649303
62Dehydration (HP:0001944)1.94930567
63Abnormality of permanent molar morphology (HP:0011071)1.91686107
64Abnormality of the dental root (HP:0006486)1.91686107
65Taurodontia (HP:0000679)1.91686107
66Acanthosis nigricans (HP:0000956)1.89422002
67Xerostomia (HP:0000217)1.88689451
68Duplicated collecting system (HP:0000081)1.87693634
69Curly hair (HP:0002212)1.85510987
70Brittle hair (HP:0002299)1.82990861
71Septate vagina (HP:0001153)1.82989411
72Dry skin (HP:0000958)1.80263338
73Abnormality of molar (HP:0011077)1.80254735
74Abnormality of molar morphology (HP:0011070)1.80254735
75Skin ulcer (HP:0200042)1.75276410
76Autoamputation (HP:0001218)1.74324554
77Depressed nasal tip (HP:0000437)1.73739710
78Anonychia (HP:0001798)1.72670604
79Abnormality of the dental pulp (HP:0006479)1.70004744
80Axonal loss (HP:0003447)1.69312552
81Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.68583214
82Aplasia involving bones of the extremities (HP:0009825)1.67781250
83Aplasia involving bones of the upper limbs (HP:0009823)1.67781250
84Aplasia of the phalanges of the hand (HP:0009802)1.67781250
85Abnormality of placental membranes (HP:0011409)1.66130073
86Amniotic constriction ring (HP:0009775)1.66130073
87Recurrent corneal erosions (HP:0000495)1.64928002
88Ventricular tachycardia (HP:0004756)1.63314406
89Multifactorial inheritance (HP:0001426)1.60573110
90Neonatal death (HP:0003811)1.59761038
91Abnormality of the renal collecting system (HP:0004742)1.59356497
92Sepsis (HP:0100806)1.58879294
93Oligodontia (HP:0000677)1.57700230
94Segmental peripheral demyelination/remyelination (HP:0003481)1.57435335
95Abnormality of the lacrimal duct (HP:0011481)1.52883548
96Paralysis (HP:0003470)1.51429692
97Urticaria (HP:0001025)1.49845223
98Anhidrosis (HP:0000970)1.48181059
99Breast hypoplasia (HP:0003187)1.45346461
100Fine hair (HP:0002213)1.43342461

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR15.69773387
2EEF2K4.43397504
3MAP3K64.14056221
4STK244.11810808
5FGFR13.95806017
6MAPKAPK33.71972277
7FER3.16785018
8EPHA22.82389414
9SGK2232.62320490
10SGK4942.62320490
11FGFR32.38009695
12RIPK12.13974618
13MAP3K22.10403159
14TRPM71.86365698
15PIK3CG1.79240224
16MAP3K31.75525084
17EPHA31.70850872
18LATS11.67898268
19ERN11.64056454
20MST1R1.59312172
21MAP3K91.51047410
22MAPKAPK51.47976809
23MAPK71.44432609
24MAPK121.41661712
25PRPF4B1.27207061
26EPHB11.26338680
27RPS6KB21.26096519
28MAP3K11.21623712
29MAP2K61.18152087
30MARK21.15300821
31MET1.12195705
32MAP3K71.10717101
33IRAK11.07708945
34FGFR21.05838145
35GRK61.05774036
36STK31.03215155
37IKBKB0.98347713
38WNK10.96416821
39SGK20.95856975
40NLK0.94315456
41RPS6KB10.92278387
42PTK20.90685531
43GSK3A0.88870894
44CDK120.86951627
45TGFBR20.85540711
46LATS20.78535337
47PRKD20.77044580
48SGK30.76266110
49ADRBK10.74830711
50MAPKAPK20.71329432
51PRKAA20.66505143
52SGK10.65511532
53STK38L0.64848324
54PBK0.63189926
55TAOK10.61908338
56MTOR0.61357259
57AKT30.61323533
58KIT0.59896621
59MAP2K40.57753105
60DMPK0.56504398
61MINK10.52196114
62LRRK20.51637010
63FGFR40.51332464
64PIM20.48521837
65PDGFRA0.47727911
66ABL20.44023956
67EPHB20.42837438
68EPHA40.42761006
69ICK0.41643267
70IRAK20.41048661
71SIK10.39929912
72MOS0.39090842
73PDGFRB0.35938000
74PRKCE0.35825797
75RET0.35607777
76STK380.34399365
77MST40.33411296
78PKN10.30451342
79KSR20.29282201
80CDK60.28988338
81GRK70.28397468
82RPS6KA20.26867070
83JAK30.26860613
84TAOK30.26566820
85IKBKE0.26229077
86MAPK90.24995787
87ABL10.24529296
88BMX0.23868441
89BRD40.23472011
90MAPK110.21292412
91HIPK20.21061831
92MAPK40.20153063
93DYRK1B0.20083517
94CDC42BPA0.19161682
95HCK0.17216128
96STK100.16943757
97BCR0.16701910
98MAP3K120.15491932
99SMG10.15100477
100CHUK0.14930744

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005926.61202841
2Linoleic acid metabolism_Homo sapiens_hsa005915.07735083
3Ether lipid metabolism_Homo sapiens_hsa005653.62292350
4Arachidonic acid metabolism_Homo sapiens_hsa005903.35459361
5Sphingolipid metabolism_Homo sapiens_hsa006002.65462117
6GnRH signaling pathway_Homo sapiens_hsa049122.36499300
7Phototransduction_Homo sapiens_hsa047442.16029471
8Histidine metabolism_Homo sapiens_hsa003402.09589089
9Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047502.04094813
10Circadian rhythm_Homo sapiens_hsa047101.96078345
11VEGF signaling pathway_Homo sapiens_hsa043701.87090147
12Ovarian steroidogenesis_Homo sapiens_hsa049131.86174841
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.85065221
14Staphylococcus aureus infection_Homo sapiens_hsa051501.69096447
15Vascular smooth muscle contraction_Homo sapiens_hsa042701.68319905
16Long-term depression_Homo sapiens_hsa047301.64643906
17Fatty acid elongation_Homo sapiens_hsa000621.62077702
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.53919081
19Glycerophospholipid metabolism_Homo sapiens_hsa005641.43757775
20Dorso-ventral axis formation_Homo sapiens_hsa043201.42363352
21Renin secretion_Homo sapiens_hsa049241.40407794
22Ras signaling pathway_Homo sapiens_hsa040141.27348898
23Serotonergic synapse_Homo sapiens_hsa047261.27070868
24Choline metabolism in cancer_Homo sapiens_hsa052311.22949902
25Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19100108
26Amoebiasis_Homo sapiens_hsa051461.12072874
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11077498
28Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.02969260
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01068784
30Sphingolipid signaling pathway_Homo sapiens_hsa040710.99045799
31Glioma_Homo sapiens_hsa052140.98188465
32Melanogenesis_Homo sapiens_hsa049160.87165331
33Oxytocin signaling pathway_Homo sapiens_hsa049210.87090722
34Phenylalanine metabolism_Homo sapiens_hsa003600.87023450
35Platelet activation_Homo sapiens_hsa046110.86718635
36Long-term potentiation_Homo sapiens_hsa047200.85128423
37Acute myeloid leukemia_Homo sapiens_hsa052210.85085721
38ECM-receptor interaction_Homo sapiens_hsa045120.84679512
39Pertussis_Homo sapiens_hsa051330.84214606
40Fat digestion and absorption_Homo sapiens_hsa049750.83981031
41Retinol metabolism_Homo sapiens_hsa008300.79925595
42ABC transporters_Homo sapiens_hsa020100.79332022
43Phospholipase D signaling pathway_Homo sapiens_hsa040720.77447766
44MicroRNAs in cancer_Homo sapiens_hsa052060.76927777
45Adherens junction_Homo sapiens_hsa045200.75578442
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72826629
47Gastric acid secretion_Homo sapiens_hsa049710.72271900
48Neurotrophin signaling pathway_Homo sapiens_hsa047220.71038469
49Estrogen signaling pathway_Homo sapiens_hsa049150.69951229
50Glutamatergic synapse_Homo sapiens_hsa047240.66408819
51p53 signaling pathway_Homo sapiens_hsa041150.66308808
52Salivary secretion_Homo sapiens_hsa049700.62453570
53Notch signaling pathway_Homo sapiens_hsa043300.61788523
54Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59708244
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59692955
56Thyroid cancer_Homo sapiens_hsa052160.58494871
57Inositol phosphate metabolism_Homo sapiens_hsa005620.56435621
58Renal cell carcinoma_Homo sapiens_hsa052110.55698872
59Pancreatic secretion_Homo sapiens_hsa049720.54852208
60Rap1 signaling pathway_Homo sapiens_hsa040150.54349292
61Tuberculosis_Homo sapiens_hsa051520.51936883
62beta-Alanine metabolism_Homo sapiens_hsa004100.51749162
63Endocytosis_Homo sapiens_hsa041440.51110583
64MAPK signaling pathway_Homo sapiens_hsa040100.50710547
65Bladder cancer_Homo sapiens_hsa052190.50028094
66Tight junction_Homo sapiens_hsa045300.49184758
67Circadian entrainment_Homo sapiens_hsa047130.49149176
68Insulin signaling pathway_Homo sapiens_hsa049100.48374543
69NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48028403
70Vitamin digestion and absorption_Homo sapiens_hsa049770.47844531
71PPAR signaling pathway_Homo sapiens_hsa033200.44538820
72Proteoglycans in cancer_Homo sapiens_hsa052050.44278906
73Glucagon signaling pathway_Homo sapiens_hsa049220.42611807
74Nitrogen metabolism_Homo sapiens_hsa009100.40027802
75Axon guidance_Homo sapiens_hsa043600.39062155
76Hepatitis C_Homo sapiens_hsa051600.37979166
77Amphetamine addiction_Homo sapiens_hsa050310.36282911
78Toxoplasmosis_Homo sapiens_hsa051450.36181270
79Hedgehog signaling pathway_Homo sapiens_hsa043400.35106775
80Pathways in cancer_Homo sapiens_hsa052000.35068424
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34809822
82Calcium signaling pathway_Homo sapiens_hsa040200.33671920
83ErbB signaling pathway_Homo sapiens_hsa040120.33122979
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.32091245
85Tyrosine metabolism_Homo sapiens_hsa003500.31561226
86Olfactory transduction_Homo sapiens_hsa047400.31493906
87Dopaminergic synapse_Homo sapiens_hsa047280.31333189
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.30335951
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.29565072
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29361238
91HIF-1 signaling pathway_Homo sapiens_hsa040660.28663649
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28188689
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.28115792
94Hippo signaling pathway_Homo sapiens_hsa043900.28038214
95Fatty acid biosynthesis_Homo sapiens_hsa000610.27944988
96Pancreatic cancer_Homo sapiens_hsa052120.27658243
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27593387
98Basal cell carcinoma_Homo sapiens_hsa052170.27213903
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26960908
100cAMP signaling pathway_Homo sapiens_hsa040240.25681318

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