ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	water homeostasis (GO:0030104)	9.53368536
2	keratinocyte proliferation (GO:0043616)	9.02241485
3	peptide cross-linking (GO:0018149)	8.94758794
4	epidermal cell differentiation (GO:0009913)	8.91888761
5	long-chain fatty acid biosynthetic process (GO:0042759)	8.71698339
6	molting cycle (GO:0042303)	8.13703880
7	hair cycle (GO:0042633)	8.13703880
8	epidermis development (GO:0008544)	7.74647678
9	skin morphogenesis (GO:0043589)	7.50864721
10	linoleic acid metabolic process (GO:0043651)	7.24118130
11	lipoxygenase pathway (GO:0019372)	7.22188722
12	detection of bacterium (GO:0016045)	7.11049141
13	bundle of His cell to Purkinje myocyte communication (GO:0086069)	6.94817340
14	detection of other organism (GO:0098543)	6.52046583
15	intermediate filament organization (GO:0045109)	5.74590130
16	phosphatidylinositol acyl-chain remodeling (GO:0036149)	5.57307586
17	phosphatidylserine acyl-chain remodeling (GO:0036150)	5.54831044
18	regulation of natural killer cell differentiation (GO:0032823)	5.53094935
19	intermediate filament cytoskeleton organization (GO:0045104)	5.08909227
20	surfactant homeostasis (GO:0043129)	4.98045322
21	intermediate filament-based process (GO:0045103)	4.93199550
22	negative regulation of interferon-gamma production (GO:0032689)	4.81365075
23	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	4.50067554
24	keratinocyte development (GO:0003334)	4.38472917
25	gap junction assembly (GO:0016264)	4.27674263
26	chemical homeostasis within a tissue (GO:0048875)	4.25350702
27	hemidesmosome assembly (GO:0031581)	4.24786374
28	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	4.22724775
29	establishment of tissue polarity (GO:0007164)	4.03544144
30	establishment of planar polarity (GO:0001736)	4.03544144
31	ectoderm development (GO:0007398)	4.03100682
32	phosphatidylcholine acyl-chain remodeling (GO:0036151)	4.01039087
33	ceramide biosynthetic process (GO:0046513)	3.89470319
34	lateral sprouting from an epithelium (GO:0060601)	3.86566494
35	detection of external biotic stimulus (GO:0098581)	3.74570924
36	polarized epithelial cell differentiation (GO:0030859)	3.69614456
37	phospholipid efflux (GO:0033700)	3.68219174
38	epithelium development (GO:0060429)	3.66288641
39	positive regulation of cholesterol efflux (GO:0010875)	3.64502391
40	fatty acid elongation (GO:0030497)	3.53518228
41	positive regulation of monocyte chemotaxis (GO:0090026)	3.49055801
42	negative regulation of interleukin-17 production (GO:0032700)	3.44542837
43	phosphatidylserine metabolic process (GO:0006658)	3.43110319
44	epithelial cell differentiation involved in prostate gland development (GO:0060742)	3.43059715
45	negative regulation of keratinocyte proliferation (GO:0010839)	3.24680830
46	regulation of keratinocyte differentiation (GO:0045616)	3.24537433
47	detection of biotic stimulus (GO:0009595)	3.19363072
48	positive regulation of sterol transport (GO:0032373)	3.16676505
49	positive regulation of cholesterol transport (GO:0032376)	3.16676505
50	positive regulation of epidermal cell differentiation (GO:0045606)	3.04248066
51	positive regulation of epidermis development (GO:0045684)	3.01824420
52	positive regulation of T cell chemotaxis (GO:0010820)	3.00365042
53	regulation of T cell chemotaxis (GO:0010819)	3.00365042
54	* keratinization (GO:0031424)	28.1494893
55	establishment of skin barrier (GO:0061436)	21.0922651
56	phospholipid catabolic process (GO:0009395)	2.95959806
57	sequestering of metal ion (GO:0051238)	2.87342103
58	defense response to fungus (GO:0050832)	2.85681847
59	regulation of keratinocyte proliferation (GO:0010837)	2.84330492
60	hair follicle morphogenesis (GO:0031069)	2.83573439
61	alditol phosphate metabolic process (GO:0052646)	2.76566228
62	regulation of natural killer cell activation (GO:0032814)	2.71963852
63	ventricular cardiac muscle cell action potential (GO:0086005)	2.64273492
64	one-carbon compound transport (GO:0019755)	2.62649094
65	regulation of epidermis development (GO:0045682)	2.62623468
66	regulation of protein localization to cell surface (GO:2000008)	2.61579910
67	sphingolipid biosynthetic process (GO:0030148)	2.60791774
68	eyelid development in camera-type eye (GO:0061029)	2.60113315
69	regulation of monocyte chemotaxis (GO:0090025)	2.59545026
70	defense response to Gram-negative bacterium (GO:0050829)	2.56730722
71	regulation of epidermal cell differentiation (GO:0045604)	2.54532556
72	regulation of neuron projection regeneration (GO:0070570)	2.49770438
73	regulation of axon regeneration (GO:0048679)	2.49770438
74	planar cell polarity pathway involved in neural tube closure (GO:0090179)	2.48607944
75	positive regulation of cellular amide metabolic process (GO:0034250)	2.46483038
76	polyol transport (GO:0015791)	2.43706091
77	epithelial cell differentiation (GO:0030855)	2.43674333
78	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	2.43559889
79	regulation of transforming growth factor beta1 production (GO:0032908)	2.42408103
80	skin development (GO:0043588)	2.37956064
81	positive regulation of keratinocyte differentiation (GO:0045618)	2.34663104
82	phosphatidylglycerol metabolic process (GO:0046471)	2.31850809
83	regulation of heart rate by cardiac conduction (GO:0086091)	2.31787394
84	regulation of cholesterol efflux (GO:0010874)	2.30528359
85	unsaturated fatty acid biosynthetic process (GO:0006636)	2.28601073
86	epithelial cell proliferation (GO:0050673)	2.23892335
87	atrioventricular valve morphogenesis (GO:0003181)	2.23590017
88	antimicrobial humoral response (GO:0019730)	2.20114654
89	molting cycle process (GO:0022404)	2.17747588
90	hair cycle process (GO:0022405)	2.17747588
91	intestinal epithelial cell development (GO:0060576)	2.14538230
92	cell communication involved in cardiac conduction (GO:0086065)	2.14531668
93	fibrinolysis (GO:0042730)	2.13224710
94	regulation of cholesterol homeostasis (GO:2000188)	2.12091048
95	epithelial cell-cell adhesion (GO:0090136)	2.06427927
96	response to phenylpropanoid (GO:0080184)	2.04057062
97	regulation of water loss via skin (GO:0033561)	18.1036965
98	desmosome organization (GO:0002934)	11.6990876
99	keratinocyte differentiation (GO:0030216)	11.4797260
100	multicellular organismal water homeostasis (GO:0050891)	11.4589490

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	5.59454885
2	P63_26484246_Chip-Seq_KERATINOCYTES_Human	4.35401368
3	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.50898613
4	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	2.97298626
5	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	2.70299559
6	SOX9_24532713_ChIP-Seq_HFSC_Mouse	2.45704839
7	HIF1A_21447827_ChIP-Seq_MCF-7_Human	2.37377660
8	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	2.36081554
9	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	2.36081554
10	TP63_23658742_ChIP-Seq_EP156T_Human	2.22883831
11	TP63_17297297_ChIP-ChIP_HaCaT_Human	13.2979119
12	RXR_22108803_ChIP-Seq_LS180_Human	1.96962532
13	TP63_22573176_ChIP-Seq_HFKS_Human	1.90657152
14	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.89502337
15	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.84961412
16	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.80215536
17	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.70482395
18	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.69131498
19	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.61279784
20	EGR1_19032775_ChIP-ChIP_M12_Human	1.60711652
21	* GATA6_21074721_ChIP-Seq_CACO-2_Human	1.50974682
22	CTCF_27219007_Chip-Seq_Bcells_Human	1.41770791
23	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.35587987
24	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.33977983
25	AR_21572438_ChIP-Seq_LNCaP_Human	1.33445110
26	ERG_20517297_ChIP-Seq_VCAP_Human	1.29226850
27	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.26254070
28	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.24684671
29	KLF5_25053715_ChIP-Seq_YYC3_Human	1.23662184
30	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.23465478
31	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.20418851
32	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.19057367
33	CJUN_26792858_Chip-Seq_BT549_Human	1.13532163
34	ATF3_27146783_Chip-Seq_COLON_Human	1.13062060
35	SOX2_20726797_ChIP-Seq_SW620_Human	1.12867509
36	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.12069813
37	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.05490298
38	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.04724195
39	TP53_18474530_ChIP-ChIP_U2OS_Human	1.04590784
40	AHR_22903824_ChIP-Seq_MCF-7_Human	1.04105344
41	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	1.02531676
42	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.00480570
43	CTCF_20526341_ChIP-Seq_ESCs_Human	0.99877273
44	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	0.99329463
45	RACK7_27058665_Chip-Seq_MCF-7_Human	0.98791080
46	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.95936661
47	ZNF263_19887448_ChIP-Seq_K562_Human	0.95849744
48	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.94643183
49	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.93998425
50	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.93240471
51	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.91995162
52	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.91007749
53	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.90268600
54	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	0.90238299
55	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.90172781
56	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.90164292
57	* E2F1_20622854_ChIP-Seq_HELA_Human	0.90008479
58	* BCOR_27268052_Chip-Seq_Bcells_Human	0.88208492
59	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.87813593
60	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.85941303
61	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.85298430
62	SMC4_20622854_ChIP-Seq_HELA_Human	0.85196927
63	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	0.82022333
64	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	0.81872104
65	RBPJ_21746931_ChIP-Seq_IB4_Human	0.80674418
66	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	0.80313848
67	* P53_21459846_ChIP-Seq_SAOS-2_Human	0.80269320
68	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.79623189
69	SMAD4_21741376_ChIP-Seq_ESCs_Human	0.78458844
70	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.78232504
71	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.77415040
72	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.77011513
73	* HNFA_21074721_ChIP-Seq_CACO-2_Human	0.75928074
74	GATA4_25053715_ChIP-Seq_YYC3_Human	0.75743350
75	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.74584768
76	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.74584768
77	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.74297382
78	CLOCK_20551151_ChIP-Seq_293T_Human	0.73614025
79	GATA6_25053715_ChIP-Seq_YYC3_Human	0.72707321
80	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.72264831
81	* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.71685207
82	TP53_16413492_ChIP-PET_HCT116_Human	0.70954823
83	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.70490452
84	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.68299070
85	MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse	0.67362928
86	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.67280885
87	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.67149780
88	GATA2_19941826_ChIP-Seq_K562_Human	0.64902477
89	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.64874295
90	TCF4_22108803_ChIP-Seq_LS180_Human	0.64696307
91	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.63102310
92	* TAF2_19829295_ChIP-Seq_ESCs_Human	0.62759593
93	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.62521592
94	LXR_22292898_ChIP-Seq_THP-1_Human	0.62339643
95	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.62271631
96	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.61788498
97	TBX20_22080862_ChIP-Seq_HEART_Mouse	0.60553209
98	TBX20_22328084_ChIP-Seq_HEART_Mouse	0.60553209
99	PPARA_22158963_ChIP-Seq_LIVER_Mouse	0.60183562
100	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.59323122

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005275_abnormal_skin_tensile	7.72742933
2	MP0005501_abnormal_skin_physiology	5.76349501
3	MP0000579_abnormal_nail_morphology	4.79486274
4	MP0010234_abnormal_vibrissa_follicle	4.52387413
5	MP0003941_abnormal_skin_development	3.95763755
6	MP0009379_abnormal_foot_pigmentation	3.41103157
7	MP0001216_abnormal_epidermal_layer	3.24562043
8	MP0003453_abnormal_keratinocyte_physiol	2.93457944
9	MP0010771_integument_phenotype	2.87778777
10	MP0004947_skin_inflammation	2.80568982
11	MP0003191_abnormal_cellular_cholesterol	2.64452414
12	MP0002060_abnormal_skin_morphology	2.58107432
13	MP0004381_abnormal_hair_follicle	2.46827315
14	MP0010678_abnormal_skin_adnexa	2.39956833
15	MP0001188_hyperpigmentation	2.29966205
16	MP0000377_abnormal_hair_follicle	2.20334232
17	MP0000383_abnormal_hair_follicle	2.19327248
18	MP0004885_abnormal_endolymph	2.17107558
19	MP0005377_hearing/vestibular/ear_phenot	2.12838350
20	MP0003878_abnormal_ear_physiology	2.12838350
21	MP0002098_abnormal_vibrissa_morphology	2.06565215
22	MP0002796_impaired_skin_barrier	10.4701568
23	MP0004782_abnormal_surfactant_physiolog	1.94491288
24	MP0003705_abnormal_hypodermis_morpholog	1.84934132
25	MP0000566_synostosis	1.83912797
26	MP0005409_darkened_coat_color	1.81397714
27	MP0009931_abnormal_skin_appearance	1.78152464
28	MP0000647_abnormal_sebaceous_gland	1.77578549
29	MP0000467_abnormal_esophagus_morphology	1.73368475
30	MP0001191_abnormal_skin_condition	1.54910741
31	MP0002095_abnormal_skin_pigmentation	1.52806387
32	MP0003011_delayed_dark_adaptation	1.48878098
33	MP0003566_abnormal_cell_adhesion	1.29201113
34	MP0000367_abnormal_coat/_hair	1.26262536
35	MP0000427_abnormal_hair_cycle	1.24277343
36	MP0010352_gastrointestinal_tract_polyps	1.23862505
37	MP0000015_abnormal_ear_pigmentation	1.18395943
38	MP0004264_abnormal_extraembryonic_tissu	1.15733610
39	MP0005174_abnormal_tail_pigmentation	1.11100896
40	MP0000465_gastrointestinal_hemorrhage	1.09950333
41	MP0000762_abnormal_tongue_morphology	1.08872898
42	MP0001784_abnormal_fluid_regulation	0.93933077
43	MP0001243_abnormal_dermal_layer	0.91853857
44	MP0005023_abnormal_wound_healing	0.80841102
45	MP0009053_abnormal_anal_canal	0.80542697
46	MP0001851_eye_inflammation	0.74081643
47	MP0002177_abnormal_outer_ear	0.71740165
48	MP0002234_abnormal_pharynx_morphology	0.55755766
49	MP0004185_abnormal_adipocyte_glucose	0.47482573
50	MP0005075_abnormal_melanosome_morpholog	0.47198124
51	MP0001340_abnormal_eyelid_morphology	0.42565280
52	MP0009780_abnormal_chondrocyte_physiolo	0.40308090
53	MP0003950_abnormal_plasma_membrane	0.39039659
54	MP0010030_abnormal_orbit_morphology	0.38522527
55	MP0001177_atelectasis	0.38152440
56	MP0005503_abnormal_tendon_morphology	0.36910760
57	MP0003315_abnormal_perineum_morphology	0.36468532
58	MP0003763_abnormal_thymus_physiology	0.35686558
59	MP0002138_abnormal_hepatobiliary_system	0.34469920
60	MP0008789_abnormal_olfactory_epithelium	0.33405495
61	MP0002009_preneoplasia	0.32432394
62	MP0008004_abnormal_stomach_pH	0.32057108
63	MP0001984_abnormal_olfaction	0.31896666
64	MP0005388_respiratory_system_phenotype	0.31774134
65	MP0002133_abnormal_respiratory_system	0.31774134
66	MP0003638_abnormal_response/metabolism_	0.30503984
67	MP0005394_taste/olfaction_phenotype	0.29208477
68	MP0005499_abnormal_olfactory_system	0.29208477
69	MP0009333_abnormal_splenocyte_physiolog	0.28703905
70	MP0000627_abnormal_mammary_gland	0.26969563
71	MP0002111_abnormal_tail_morphology	0.26965692
72	MP0004197_abnormal_fetal_growth/weight/	0.24374585
73	MP0000569_abnormal_digit_pigmentation	0.23783485
74	MP0009672_abnormal_birth_weight	0.23063507
75	MP0008438_abnormal_cutaneous_collagen	0.20615072
76	MP0002282_abnormal_trachea_morphology	0.20338320
77	MP0001186_pigmentation_phenotype	0.20315712
78	MP0003755_abnormal_palate_morphology	0.19162082
79	MP0005257_abnormal_intraocular_pressure	0.18544776
80	MP0000685_abnormal_immune_system	0.18095689
81	MP0002697_abnormal_eye_size	0.17813724
82	MP0001485_abnormal_pinna_reflex	0.17711481
83	MP0002877_abnormal_melanocyte_morpholog	0.15726733
84	MP0003300_gastrointestinal_ulcer	0.15041161
85	MP0005076_abnormal_cell_differentiation	0.13749480
86	MP0000428_abnormal_craniofacial_morphol	0.13671736
87	MP0002233_abnormal_nose_morphology	0.13660254
88	MP0005666_abnormal_adipose_tissue	0.13001260
89	MP0005193_abnormal_anterior_eye	0.12798976
90	MP0005375_adipose_tissue_phenotype	0.12775457
91	MP0000432_abnormal_head_morphology	0.12520280
92	MP0004043_abnormal_pH_regulation	0.12380309
93	MP0003828_pulmonary_edema	0.09283007
94	MP0008569_lethality_at_weaning	0.09166022
95	MP0001299_abnormal_eye_distance/	0.09160282
96	MP0005508_abnormal_skeleton_morphology	0.08748428
97	MP0004272_abnormal_basement_membrane	0.08482084
98	MP0005171_absent_coat_pigmentation	0.08149467
99	MP0001958_emphysema	0.08075069
100	MP0002006_tumorigenesis	0.06011170

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased IgE level (HP:0003212)	9.61028427
2	Congenital ichthyosiform erythroderma (HP:0007431)	8.45264039
3	Palmoplantar hyperkeratosis (HP:0000972)	8.25403958
4	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	8.20237342
5	Erythroderma (HP:0001019)	7.92174620
6	Palmar hyperkeratosis (HP:0010765)	7.85298975
7	Onycholysis (HP:0001806)	6.93742417
8	Plantar hyperkeratosis (HP:0007556)	6.69165773
9	Hypotrichosis (HP:0001006)	6.63483616
10	Alopecia of scalp (HP:0002293)	6.60774439
11	Erythema (HP:0010783)	6.41439389
12	Abnormality of the axillary hair (HP:0100134)	6.09962345
13	Abnormality of secondary sexual hair (HP:0009888)	6.09962345
14	Parakeratosis (HP:0001036)	5.86995092
15	Corneal erosion (HP:0200020)	5.86101254
16	Thick nail (HP:0001805)	5.76055871
17	Oral leukoplakia (HP:0002745)	5.43038509
18	Gangrene (HP:0100758)	4.52556988
19	Palmoplantar keratoderma (HP:0000982)	4.51734306
20	Ectropion (HP:0000656)	4.41390074
21	Conjunctival hamartoma (HP:0100780)	4.40702828
22	Hypohidrosis (HP:0000966)	4.39919283
23	Right ventricular cardiomyopathy (HP:0011663)	4.26239373
24	Woolly hair (HP:0002224)	4.20568969
25	Absent eyelashes (HP:0000561)	3.63262106
26	Nail dystrophy (HP:0008404)	3.59554345
27	Sparse eyelashes (HP:0000653)	3.55902692
28	Fragile nails (HP:0001808)	3.46984682
29	Abnormal blistering of the skin (HP:0008066)	3.29760577
30	Lip pit (HP:0100267)	3.21988384
31	Absent hair (HP:0002298)	3.21801580
32	Pruritus (HP:0000989)	3.16545658
33	Abnormality of the salivary glands (HP:0010286)	3.08284482
34	Eczematoid dermatitis (HP:0000976)	3.04594372
35	Sparse scalp hair (HP:0002209)	3.01117804
36	Hamartoma of the eye (HP:0010568)	2.95568799
37	Follicular hyperkeratosis (HP:0007502)	2.85460040
38	Lack of skin elasticity (HP:0100679)	2.67340566
39	Furrowed tongue (HP:0000221)	2.59311633
40	Abnormal hair laboratory examination (HP:0003328)	2.57660935
41	Blepharitis (HP:0000498)	2.47747244
42	Hypergammaglobulinemia (HP:0010702)	2.46884771
43	Pili torti (HP:0003777)	2.45011612
44	Pustule (HP:0200039)	2.42409592
45	Hypoplastic labia majora (HP:0000059)	2.28501377
46	Autoamputation (HP:0001218)	2.21943196
47	Abnormality of placental membranes (HP:0011409)	2.20032634
48	Amniotic constriction ring (HP:0009775)	2.20032634
49	Natal tooth (HP:0000695)	2.17472418
50	Slow-growing hair (HP:0002217)	2.13184960
51	Abnormality of hair growth rate (HP:0011363)	2.13184960
52	Abnormality of the labia majora (HP:0012881)	2.07854834
53	Dehydration (HP:0001944)	2.05694360
54	Milia (HP:0001056)	2.04359075
55	Selective tooth agenesis (HP:0001592)	2.04065957
56	Laryngomalacia (HP:0001601)	2.02626983
57	Hyperhidrosis (HP:0000975)	2.01999698
58	Brittle hair (HP:0002299)	2.01120019
59	Split foot (HP:0001839)	2.00825493
60	Melanocytic nevus (HP:0000995)	2.00783052
61	Abnormality of nail color (HP:0100643)	11.8589920
62	Advanced eruption of teeth (HP:0006288)	1.95172296
63	Ridged nail (HP:0001807)	1.90133156
64	Recurrent corneal erosions (HP:0000495)	1.84880339
65	Multifactorial inheritance (HP:0001426)	1.83646292
66	Paralysis (HP:0003470)	1.80243780
67	Urticaria (HP:0001025)	1.79444872
68	Dry skin (HP:0000958)	1.78728586
69	Duplicated collecting system (HP:0000081)	1.78307416
70	Sepsis (HP:0100806)	1.74647097
71	Septate vagina (HP:0001153)	1.74531204
72	Curly hair (HP:0002212)	1.74383294
73	Depressed nasal tip (HP:0000437)	1.73156810
74	Acanthosis nigricans (HP:0000956)	1.72211619
75	Conical tooth (HP:0000698)	1.71186047
76	Xerostomia (HP:0000217)	1.71012958
77	Anonychia (HP:0001798)	1.70800488
78	Skin ulcer (HP:0200042)	1.69437484
79	Nasolacrimal duct obstruction (HP:0000579)	1.68076415
80	Hamartoma (HP:0010566)	1.67327715
81	Abnormality of the dental root (HP:0006486)	1.65785591
82	Taurodontia (HP:0000679)	1.65785591
83	Abnormality of permanent molar morphology (HP:0011071)	1.65785591
84	Corneal dystrophy (HP:0001131)	1.57280625
85	Abnormality of molar morphology (HP:0011070)	1.57211948
86	Abnormality of molar (HP:0011077)	1.57211948
87	Fine hair (HP:0002213)	1.53695683
88	Anhidrosis (HP:0000970)	1.53608654
89	Carious teeth (HP:0000670)	1.52268014
90	Abnormality of the renal collecting system (HP:0004742)	1.51246172
91	Oligodontia (HP:0000677)	1.48499000
92	Abnormality of the dental pulp (HP:0006479)	1.48117103
93	Breast hypoplasia (HP:0003187)	1.44719306
94	Ventricular tachycardia (HP:0004756)	1.43270307
95	Abnormality of the fingernails (HP:0001231)	1.41583207
96	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.39678445
97	Papilloma (HP:0012740)	1.39264904
98	Verrucae (HP:0200043)	1.39264904
99	Keratoconjunctivitis sicca (HP:0001097)	1.39036162
100	Axonal loss (HP:0003447)	1.36993747

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TGFBR1	6.29786016
2	STK24	3.72426306
3	MAP3K6	3.63641010
4	EPHA2	3.52462197
5	FGFR1	3.50212367
6	FER	3.34303301
7	EEF2K	3.09291065
8	MAPKAPK3	2.88019923
9	SGK494	2.57577188
10	SGK223	2.57577188
11	MAP3K2	2.24542245
12	RIPK1	2.19626252
13	MAP3K9	2.17910401
14	ERN1	2.02516275
15	FGFR3	2.02024582
16	MAP3K3	1.84710043
17	PIK3CG	1.77582037
18	EPHA3	1.76290539
19	LATS1	1.65848541
20	WNK1	1.53703078
21	GRK6	1.52276563
22	TRPM7	1.46969794
23	MET	1.46694742
24	MAPK7	1.39277591
25	IRAK1	1.31990126
26	EPHB1	1.29714500
27	MST1R	1.26937060
28	MAP3K1	1.16115641
29	IKBKB	1.14636137
30	MAPK12	1.13997758
31	MAP2K6	1.13170801
32	PTK2	1.12402772
33	MAPKAPK5	1.10429293
34	CDK12	1.08123934
35	SGK2	1.04873174
36	MARK2	0.99888498
37	AKT3	0.98781350
38	TGFBR2	0.98564908
39	STK3	0.94268075
40	RPS6KB1	0.92496843
41	NLK	0.90025505
42	MAP3K7	0.89627961
43	PRPF4B	0.88333743
44	PDGFRA	0.87544526
45	ADRBK1	0.86383981
46	FGFR2	0.86233678
47	DMPK	0.86215245
48	LATS2	0.84653821
49	SGK3	0.82558011
50	RPS6KB2	0.79558967
51	GSK3A	0.74090759
52	MAPKAPK2	0.73301653
53	TAOK1	0.71382042
54	STK38L	0.70692882
55	PIM2	0.67174571
56	IRAK2	0.65018639
57	MST4	0.63711408
58	PRKD2	0.63087611
59	SGK1	0.62831435
60	MTOR	0.61768024
61	ABL2	0.56609094
62	PRKAA2	0.55995356
63	PDGFRB	0.55514178
64	KIT	0.52401049
65	FGFR4	0.50927707
66	STK38	0.49310423
67	MAP2K4	0.45991899
68	EPHB2	0.45576370
69	IKBKE	0.44131813
70	FLT3	0.43956449
71	LRRK2	0.43255236
72	PKN1	0.40211266
73	JAK3	0.39448091
74	CDC42BPA	0.36950229
75	PBK	0.36884175
76	PRKCE	0.34966090
77	RET	0.34759942
78	ABL1	0.33909493
79	TAOK3	0.33902223
80	BRD4	0.33757172
81	EPHA4	0.32984240
82	GRK7	0.31733300
83	BMX	0.31351892
84	SIK1	0.31113575
85	MINK1	0.31006737
86	CDK6	0.30889345
87	MOS	0.30756279
88	MAPK4	0.30702151
89	PAK2	0.30613358
90	HIPK2	0.29675038
91	MYLK	0.26595966
92	IRAK4	0.24608356
93	KSR2	0.23289092
94	MAP3K5	0.23243432
95	MAPK9	0.22749700
96	TYRO3	0.21596537
97	BCR	0.21375032
98	GRK5	0.21293003
99	MAP3K12	0.21164807
100	RPS6KA2	0.20158482

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	6.53923134
2	Linoleic acid metabolism_Homo sapiens_hsa00591	5.09628680
3	Ether lipid metabolism_Homo sapiens_hsa00565	3.62863825
4	Arachidonic acid metabolism_Homo sapiens_hsa00590	3.49849875
5	Sphingolipid metabolism_Homo sapiens_hsa00600	2.60309527
6	GnRH signaling pathway_Homo sapiens_hsa04912	2.36435273
7	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.22009667
8	Phototransduction_Homo sapiens_hsa04744	2.16261804
9	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	2.09406310
10	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.95505514
11	VEGF signaling pathway_Homo sapiens_hsa04370	1.92952819
12	Histidine metabolism_Homo sapiens_hsa00340	1.89777868
13	Circadian rhythm_Homo sapiens_hsa04710	1.79545987
14	Long-term depression_Homo sapiens_hsa04730	1.70262898
15	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.69945274
16	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.61571573
17	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.59754572
18	Renin secretion_Homo sapiens_hsa04924	1.42126685
19	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.41986566
20	Fatty acid elongation_Homo sapiens_hsa00062	1.39522423
21	Serotonergic synapse_Homo sapiens_hsa04726	1.36238361
22	Choline metabolism in cancer_Homo sapiens_hsa05231	1.27917147
23	Ras signaling pathway_Homo sapiens_hsa04014	1.25930378
24	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.25154810
25	Amoebiasis_Homo sapiens_hsa05146	1.23015546
26	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.14126425
27	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.13062514
28	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.06390623
29	Glioma_Homo sapiens_hsa05214	1.04360230
30	ABC transporters_Homo sapiens_hsa02010	1.01955519
31	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.97240921
32	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.94935370
33	Pertussis_Homo sapiens_hsa05133	0.91223218
34	Platelet activation_Homo sapiens_hsa04611	0.90847669
35	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.90767977
36	Acute myeloid leukemia_Homo sapiens_hsa05221	0.89486652
37	Melanogenesis_Homo sapiens_hsa04916	0.83537397
38	Long-term potentiation_Homo sapiens_hsa04720	0.82912447
39	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.82618194
40	Fat digestion and absorption_Homo sapiens_hsa04975	0.77218079
41	Phenylalanine metabolism_Homo sapiens_hsa00360	0.77172086
42	Adherens junction_Homo sapiens_hsa04520	0.75687216
43	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.75395851
44	MicroRNAs in cancer_Homo sapiens_hsa05206	0.75377596
45	Estrogen signaling pathway_Homo sapiens_hsa04915	0.74313063
46	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.73967766
47	ECM-receptor interaction_Homo sapiens_hsa04512	0.73563378
48	Gastric acid secretion_Homo sapiens_hsa04971	0.72563132
49	p53 signaling pathway_Homo sapiens_hsa04115	0.70403302
50	Glutamatergic synapse_Homo sapiens_hsa04724	0.66988512
51	Thyroid cancer_Homo sapiens_hsa05216	0.60984229
52	Retinol metabolism_Homo sapiens_hsa00830	0.60960111
53	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.59275190
54	Tuberculosis_Homo sapiens_hsa05152	0.59018443
55	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.57459098
56	Renal cell carcinoma_Homo sapiens_hsa05211	0.57131258
57	Salivary secretion_Homo sapiens_hsa04970	0.55915601
58	Bladder cancer_Homo sapiens_hsa05219	0.55447555
59	MAPK signaling pathway_Homo sapiens_hsa04010	0.54298527
60	Rap1 signaling pathway_Homo sapiens_hsa04015	0.54261259
61	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.54142399
62	Pancreatic secretion_Homo sapiens_hsa04972	0.53842243
63	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.48223366
64	Tight junction_Homo sapiens_hsa04530	0.47970754
65	Endocytosis_Homo sapiens_hsa04144	0.47493510
66	Insulin signaling pathway_Homo sapiens_hsa04910	0.47187579
67	Proteoglycans in cancer_Homo sapiens_hsa05205	0.46262953
68	Notch signaling pathway_Homo sapiens_hsa04330	0.45644456
69	Circadian entrainment_Homo sapiens_hsa04713	0.44510159
70	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.43309564
71	beta-Alanine metabolism_Homo sapiens_hsa00410	0.43038574
72	PPAR signaling pathway_Homo sapiens_hsa03320	0.42964990
73	Amphetamine addiction_Homo sapiens_hsa05031	0.41297288
74	Arginine biosynthesis_Homo sapiens_hsa00220	0.40703864
75	Glucagon signaling pathway_Homo sapiens_hsa04922	0.39378340
76	ErbB signaling pathway_Homo sapiens_hsa04012	0.38182256
77	Axon guidance_Homo sapiens_hsa04360	0.36817144
78	Hepatitis C_Homo sapiens_hsa05160	0.36117560
79	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.35785193
80	cAMP signaling pathway_Homo sapiens_hsa04024	0.33770395
81	Olfactory transduction_Homo sapiens_hsa04740	0.33178201
82	Pathways in cancer_Homo sapiens_hsa05200	0.32535735
83	Calcium signaling pathway_Homo sapiens_hsa04020	0.31696406
84	Toxoplasmosis_Homo sapiens_hsa05145	0.31370258
85	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.31249472
86	Basal cell carcinoma_Homo sapiens_hsa05217	0.30433622
87	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.30010451
88	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.29769549
89	Hippo signaling pathway_Homo sapiens_hsa04390	0.29294642
90	Dopaminergic synapse_Homo sapiens_hsa04728	0.28897744
91	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.28737710
92	Malaria_Homo sapiens_hsa05144	0.28364524
93	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.27937946
94	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.27626975
95	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.26417785
96	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.26031076
97	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.25795721
98	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.25778701
99	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.25367079
100	Pancreatic cancer_Homo sapiens_hsa05212	0.24907040

LCE2C

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »