ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	hair cycle (GO:0042633)	9.24544992
2	molting cycle (GO:0042303)	9.24544992
3	water homeostasis (GO:0030104)	9.23261944
4	epidermal cell differentiation (GO:0009913)	8.98653618
5	peptide cross-linking (GO:0018149)	8.82994624
6	keratinocyte proliferation (GO:0043616)	8.71612152
7	long-chain fatty acid biosynthetic process (GO:0042759)	8.41912730
8	epidermis development (GO:0008544)	7.79123529
9	skin morphogenesis (GO:0043589)	7.08215644
10	lipoxygenase pathway (GO:0019372)	7.05040017
11	linoleic acid metabolic process (GO:0043651)	7.03916603
12	detection of bacterium (GO:0016045)	6.99147981
13	bundle of His cell to Purkinje myocyte communication (GO:0086069)	6.56120887
14	detection of other organism (GO:0098543)	6.39958285
15	intermediate filament organization (GO:0045109)	6.02232653
16	phosphatidylserine acyl-chain remodeling (GO:0036150)	5.69246409
17	phosphatidylinositol acyl-chain remodeling (GO:0036149)	5.67573693
18	regulation of natural killer cell differentiation (GO:0032823)	5.42909118
19	intermediate filament cytoskeleton organization (GO:0045104)	5.21183545
20	intermediate filament-based process (GO:0045103)	5.05064239
21	surfactant homeostasis (GO:0043129)	4.87548169
22	negative regulation of interferon-gamma production (GO:0032689)	4.82183828
23	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	4.70945074
24	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	4.48855457
25	keratinocyte development (GO:0003334)	4.35185348
26	chemical homeostasis within a tissue (GO:0048875)	4.22621118
27	phosphatidylcholine acyl-chain remodeling (GO:0036151)	4.19482308
28	ectoderm development (GO:0007398)	4.15824770
29	hemidesmosome assembly (GO:0031581)	4.08936468
30	fatty acid elongation (GO:0030497)	4.06376981
31	ceramide biosynthetic process (GO:0046513)	3.92573165
32	gap junction assembly (GO:0016264)	3.90759059
33	positive regulation of cellular amide metabolic process (GO:0034250)	3.90138925
34	establishment of planar polarity (GO:0001736)	3.75612005
35	establishment of tissue polarity (GO:0007164)	3.75612005
36	negative regulation of interleukin-17 production (GO:0032700)	3.71858612
37	phospholipid efflux (GO:0033700)	3.70546447
38	positive regulation of cholesterol efflux (GO:0010875)	3.65699393
39	epithelium development (GO:0060429)	3.65632331
40	detection of external biotic stimulus (GO:0098581)	3.64892467
41	phosphatidylserine metabolic process (GO:0006658)	3.49047993
42	defense response to fungus (GO:0050832)	3.46472388
43	regulation of transforming growth factor beta1 production (GO:0032908)	3.36985356
44	lateral sprouting from an epithelium (GO:0060601)	3.32292006
45	positive regulation of epidermis development (GO:0045684)	3.29950710
46	polarized epithelial cell differentiation (GO:0030859)	3.28455443
47	positive regulation of monocyte chemotaxis (GO:0090026)	3.25796065
48	positive regulation of epidermal cell differentiation (GO:0045606)	3.24494351
49	positive regulation of cholesterol transport (GO:0032376)	3.20462797
50	positive regulation of sterol transport (GO:0032373)	3.20462797
51	regulation of keratinocyte differentiation (GO:0045616)	3.19316811
52	negative regulation of keratinocyte proliferation (GO:0010839)	3.18653519
53	defense response to Gram-negative bacterium (GO:0050829)	3.18642041
54	detection of biotic stimulus (GO:0009595)	3.10631299
55	* keratinization (GO:0031424)	28.6856431
56	establishment of skin barrier (GO:0061436)	20.4153638
57	epithelial cell differentiation involved in prostate gland development (GO:0060742)	2.99748695
58	phospholipid catabolic process (GO:0009395)	2.93027810
59	hair follicle morphogenesis (GO:0031069)	2.89562717
60	positive regulation of glomerulus development (GO:0090193)	2.80783110
61	positive regulation of T cell chemotaxis (GO:0010820)	2.80432871
62	regulation of T cell chemotaxis (GO:0010819)	2.80432871
63	alditol phosphate metabolic process (GO:0052646)	2.79927736
64	antimicrobial humoral response (GO:0019730)	2.75391688
65	regulation of epidermis development (GO:0045682)	2.72754705
66	positive regulation of interleukin-8 secretion (GO:2000484)	2.67795100
67	positive regulation of keratinocyte differentiation (GO:0045618)	2.67723611
68	regulation of keratinocyte proliferation (GO:0010837)	2.67363579
69	sequestering of metal ion (GO:0051238)	2.66364895
70	regulation of natural killer cell activation (GO:0032814)	2.66323179
71	regulation of axon regeneration (GO:0048679)	2.64092116
72	regulation of neuron projection regeneration (GO:0070570)	2.64092116
73	sphingolipid biosynthetic process (GO:0030148)	2.62047550
74	regulation of protein localization to cell surface (GO:2000008)	2.60165035
75	regulation of epidermal cell differentiation (GO:0045604)	2.56771649
76	eyelid development in camera-type eye (GO:0061029)	2.50851364
77	ventricular cardiac muscle cell action potential (GO:0086005)	2.50159297
78	regulation of cell proliferation involved in kidney development (GO:1901722)	2.48644345
79	epithelial cell differentiation (GO:0030855)	2.43739134
80	one-carbon compound transport (GO:0019755)	2.40860830
81	positive regulation of p38MAPK cascade (GO:1900745)	2.40482531
82	phosphatidylglycerol metabolic process (GO:0046471)	2.39928946
83	regulation of monocyte chemotaxis (GO:0090025)	2.39890902
84	planar cell polarity pathway involved in neural tube closure (GO:0090179)	2.39085377
85	skin development (GO:0043588)	2.38545882
86	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	2.33971235
87	regulation of cholesterol homeostasis (GO:2000188)	2.32500891
88	regulation of cholesterol efflux (GO:0010874)	2.31734697
89	polyol transport (GO:0015791)	2.26825914
90	response to fungus (GO:0009620)	2.25940872
91	positive regulation of humoral immune response (GO:0002922)	2.20766261
92	regulation of heart rate by cardiac conduction (GO:0086091)	2.16988055
93	unsaturated fatty acid biosynthetic process (GO:0006636)	2.15827540
94	retinol metabolic process (GO:0042572)	2.15396855
95	response to UV-B (GO:0010224)	2.15275239
96	intestinal epithelial cell development (GO:0060576)	2.15072896
97	regulation of water loss via skin (GO:0033561)	17.5025500
98	desmosome organization (GO:0002934)	11.5376618
99	keratinocyte differentiation (GO:0030216)	11.4182209
100	multicellular organismal water homeostasis (GO:0050891)	11.0833961

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	6.06535273
2	P63_26484246_Chip-Seq_KERATINOCYTES_Human	4.42918006
3	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	4.10506285
4	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	2.89957979
5	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	2.82767393
6	HIF1A_21447827_ChIP-Seq_MCF-7_Human	2.55416351
7	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	2.48447768
8	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	2.48447768
9	SOX9_24532713_ChIP-Seq_HFSC_Mouse	2.40677871
10	TP63_23658742_ChIP-Seq_EP156T_Human	2.23344125
11	TP63_17297297_ChIP-ChIP_HaCaT_Human	13.0408901
12	RXR_22108803_ChIP-Seq_LS180_Human	1.99572005
13	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.93142759
14	TP63_22573176_ChIP-Seq_HFKS_Human	1.86426710
15	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.84949691
16	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.81943152
17	* GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.81389917
18	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.61202183
19	EGR1_19032775_ChIP-ChIP_M12_Human	1.59351240
20	* GATA6_21074721_ChIP-Seq_CACO-2_Human	1.53208503
21	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.49773239
22	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.38704306
23	ERG_20517297_ChIP-Seq_VCAP_Human	1.31749684
24	* CTCF_27219007_Chip-Seq_Bcells_Human	1.30270428
25	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.24035291
26	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.22964845
27	ATF3_27146783_Chip-Seq_COLON_Human	1.21181057
28	KLF5_25053715_ChIP-Seq_YYC3_Human	1.21172137
29	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.21171019
30	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.21113931
31	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.19860630
32	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.19004333
33	AR_21572438_ChIP-Seq_LNCaP_Human	1.14901187
34	SOX2_20726797_ChIP-Seq_SW620_Human	1.13606469
35	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.13316413
36	CJUN_26792858_Chip-Seq_BT549_Human	1.06725370
37	CTCF_20526341_ChIP-Seq_ESCs_Human	1.06659444
38	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.06030446
39	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.04326740
40	TP53_18474530_ChIP-ChIP_U2OS_Human	1.04226474
41	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.03408386
42	E2F1_20622854_ChIP-Seq_HELA_Human	1.03218193
43	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	1.02186975
44	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.01647344
45	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.99915303
46	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.99306419
47	P53_21459846_ChIP-Seq_SAOS-2_Human	0.99304706
48	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.99103333
49	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	0.98928869
50	BCOR_27268052_Chip-Seq_Bcells_Human	0.98153776
51	RACK7_27058665_Chip-Seq_MCF-7_Human	0.98059722
52	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.96758700
53	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.96051003
54	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.95468010
55	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.93471381
56	AHR_22903824_ChIP-Seq_MCF-7_Human	0.92737567
57	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.91702972
58	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.91340884
59	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.91310900
60	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.89485985
61	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.88553471
62	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	0.87430104
63	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.87074986
64	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	0.86998029
65	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	0.85631363
66	SMC4_20622854_ChIP-Seq_HELA_Human	0.85033433
67	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.84940140
68	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.82190557
69	GATA4_25053715_ChIP-Seq_YYC3_Human	0.81610289
70	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.80461125
71	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.80246897
72	RBPJ_21746931_ChIP-Seq_IB4_Human	0.80092191
73	SMAD4_21741376_ChIP-Seq_ESCs_Human	0.78504964
74	CLOCK_20551151_ChIP-Seq_293T_Human	0.77252240
75	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.76322215
76	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.76322215
77	TAF2_19829295_ChIP-Seq_ESCs_Human	0.75473104
78	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.74284131
79	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.73924442
80	ZNF263_19887448_ChIP-Seq_K562_Human	0.73867496
81	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.72401996
82	TP53_16413492_ChIP-PET_HCT116_Human	0.72368902
83	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.71549894
84	GATA6_25053715_ChIP-Seq_YYC3_Human	0.71193959
85	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.70428173
86	CEBPB_22108803_ChIP-Seq_LS180_Human	0.69733700
87	MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse	0.69327425
88	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.68552782
89	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.68452538
90	PPARA_22158963_ChIP-Seq_LIVER_Mouse	0.66864721
91	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.64745019
92	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.64154615
93	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.63690226
94	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.62825104
95	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.62511503
96	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.62207375
97	SPI1_20517297_ChIP-Seq_HL60_Human	0.61118602
98	NCOR_22424771_ChIP-Seq_293T_Human	0.60916365
99	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.60385430
100	BCL6_27268052_Chip-Seq_Bcells_Human	0.60230181

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005275_abnormal_skin_tensile	7.46009194
2	MP0005501_abnormal_skin_physiology	5.72276225
3	MP0000579_abnormal_nail_morphology	4.97056900
4	MP0010234_abnormal_vibrissa_follicle	4.91324943
5	MP0003941_abnormal_skin_development	4.04025464
6	MP0001216_abnormal_epidermal_layer	3.24012414
7	MP0009379_abnormal_foot_pigmentation	3.16585699
8	MP0003453_abnormal_keratinocyte_physiol	3.01538486
9	MP0010771_integument_phenotype	2.88978217
10	MP0004947_skin_inflammation	2.83441120
11	MP0004381_abnormal_hair_follicle	2.75771858
12	MP0003191_abnormal_cellular_cholesterol	2.67290921
13	MP0010678_abnormal_skin_adnexa	2.58800488
14	MP0002060_abnormal_skin_morphology	2.56193775
15	MP0000383_abnormal_hair_follicle	2.33434188
16	MP0000377_abnormal_hair_follicle	2.27240856
17	MP0002098_abnormal_vibrissa_morphology	2.24761728
18	MP0001188_hyperpigmentation	2.18953589
19	MP0002796_impaired_skin_barrier	10.4090838
20	MP0004782_abnormal_surfactant_physiolog	1.99110134
21	MP0004885_abnormal_endolymph	1.98811064
22	MP0003878_abnormal_ear_physiology	1.96098746
23	MP0005377_hearing/vestibular/ear_phenot	1.96098746
24	MP0000647_abnormal_sebaceous_gland	1.83503961
25	MP0000566_synostosis	1.80356137
26	MP0000467_abnormal_esophagus_morphology	1.79769117
27	MP0009931_abnormal_skin_appearance	1.77192418
28	MP0005409_darkened_coat_color	1.76219979
29	MP0003705_abnormal_hypodermis_morpholog	1.73311351
30	MP0003011_delayed_dark_adaptation	1.59525846
31	MP0002095_abnormal_skin_pigmentation	1.50241100
32	MP0001191_abnormal_skin_condition	1.50224266
33	MP0000367_abnormal_coat/_hair	1.32674619
34	MP0000427_abnormal_hair_cycle	1.25061383
35	MP0003566_abnormal_cell_adhesion	1.22451866
36	MP0000015_abnormal_ear_pigmentation	1.16076236
37	MP0000762_abnormal_tongue_morphology	1.14691605
38	MP0010352_gastrointestinal_tract_polyps	1.13197031
39	MP0005174_abnormal_tail_pigmentation	1.09285292
40	MP0004264_abnormal_extraembryonic_tissu	1.09237392
41	MP0000465_gastrointestinal_hemorrhage	1.07631744
42	MP0001243_abnormal_dermal_layer	0.92222319
43	MP0001784_abnormal_fluid_regulation	0.91877688
44	MP0009053_abnormal_anal_canal	0.79457303
45	MP0005023_abnormal_wound_healing	0.79061382
46	MP0001851_eye_inflammation	0.74225036
47	MP0002177_abnormal_outer_ear	0.67716205
48	MP0005075_abnormal_melanosome_morpholog	0.62931604
49	MP0003950_abnormal_plasma_membrane	0.61753397
50	MP0002234_abnormal_pharynx_morphology	0.57216393
51	MP0004185_abnormal_adipocyte_glucose	0.51131599
52	MP0001340_abnormal_eyelid_morphology	0.42128804
53	MP0001177_atelectasis	0.40141797
54	MP0008004_abnormal_stomach_pH	0.35888836
55	MP0003315_abnormal_perineum_morphology	0.35853619
56	MP0001984_abnormal_olfaction	0.34506251
57	MP0010030_abnormal_orbit_morphology	0.32895707
58	MP0003763_abnormal_thymus_physiology	0.32877905
59	MP0009333_abnormal_splenocyte_physiolog	0.32659854
60	MP0002138_abnormal_hepatobiliary_system	0.30692602
61	MP0005388_respiratory_system_phenotype	0.30536495
62	MP0002133_abnormal_respiratory_system	0.30536495
63	MP0002009_preneoplasia	0.30108309
64	MP0008789_abnormal_olfactory_epithelium	0.27804018
65	MP0003638_abnormal_response/metabolism_	0.27612662
66	MP0009780_abnormal_chondrocyte_physiolo	0.26278520
67	MP0000627_abnormal_mammary_gland	0.24764757
68	MP0002111_abnormal_tail_morphology	0.24596165
69	MP0000569_abnormal_digit_pigmentation	0.23891846
70	MP0005394_taste/olfaction_phenotype	0.23571668
71	MP0005499_abnormal_olfactory_system	0.23571668
72	MP0009672_abnormal_birth_weight	0.23011529
73	MP0005503_abnormal_tendon_morphology	0.22971936
74	MP0004197_abnormal_fetal_growth/weight/	0.22880899
75	MP0005171_absent_coat_pigmentation	0.21443352
76	MP0003755_abnormal_palate_morphology	0.21200822
77	MP0001186_pigmentation_phenotype	0.20952836
78	MP0002282_abnormal_trachea_morphology	0.17377603
79	MP0002697_abnormal_eye_size	0.17209351
80	MP0003300_gastrointestinal_ulcer	0.15816001
81	MP0005257_abnormal_intraocular_pressure	0.15661978
82	MP0004272_abnormal_basement_membrane	0.15580024
83	MP0005375_adipose_tissue_phenotype	0.15544406
84	MP0002877_abnormal_melanocyte_morpholog	0.15495815
85	MP0000685_abnormal_immune_system	0.14668958
86	MP0001485_abnormal_pinna_reflex	0.14659328
87	MP0005666_abnormal_adipose_tissue	0.14401335
88	MP0004043_abnormal_pH_regulation	0.13229649
89	MP0005076_abnormal_cell_differentiation	0.13120043
90	MP0002233_abnormal_nose_morphology	0.12357434
91	MP0003828_pulmonary_edema	0.11990469
92	MP0005193_abnormal_anterior_eye	0.10979745
93	MP0008438_abnormal_cutaneous_collagen	0.10051616
94	MP0000432_abnormal_head_morphology	0.09688309
95	MP0008569_lethality_at_weaning	0.07608751
96	MP0001502_abnormal_circadian_rhythm	0.07392177
97	MP0000428_abnormal_craniofacial_morphol	0.06863884
98	MP0005508_abnormal_skeleton_morphology	0.05444028
99	MP0001756_abnormal_urination	0.05226538
100	MP0002006_tumorigenesis	0.04794530

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased IgE level (HP:0003212)	9.61954313
2	Congenital ichthyosiform erythroderma (HP:0007431)	8.59753445
3	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	8.40668126
4	Palmoplantar hyperkeratosis (HP:0000972)	8.38142080
5	Palmar hyperkeratosis (HP:0010765)	7.97437575
6	Erythroderma (HP:0001019)	7.90061229
7	Onycholysis (HP:0001806)	6.82147107
8	Plantar hyperkeratosis (HP:0007556)	6.79509659
9	Hypotrichosis (HP:0001006)	6.59809688
10	Erythema (HP:0010783)	6.59340447
11	Parakeratosis (HP:0001036)	6.38509892
12	Alopecia of scalp (HP:0002293)	6.16202647
13	Thick nail (HP:0001805)	5.98392882
14	Oral leukoplakia (HP:0002745)	5.78667835
15	Corneal erosion (HP:0200020)	5.73566613
16	Abnormality of secondary sexual hair (HP:0009888)	5.68811889
17	Abnormality of the axillary hair (HP:0100134)	5.68811889
18	Gangrene (HP:0100758)	4.61130651
19	Palmoplantar keratoderma (HP:0000982)	4.59239316
20	Ectropion (HP:0000656)	4.49124848
21	Hypohidrosis (HP:0000966)	4.41994177
22	Woolly hair (HP:0002224)	4.22219436
23	Conjunctival hamartoma (HP:0100780)	4.20015753
24	Right ventricular cardiomyopathy (HP:0011663)	4.11334238
25	Nail dystrophy (HP:0008404)	3.69945497
26	Fragile nails (HP:0001808)	3.58620907
27	Absent eyelashes (HP:0000561)	3.47207750
28	Sparse eyelashes (HP:0000653)	3.36933810
29	Lip pit (HP:0100267)	3.36254864
30	Abnormal blistering of the skin (HP:0008066)	3.36143392
31	Follicular hyperkeratosis (HP:0007502)	3.27727512
32	Pruritus (HP:0000989)	3.26655233
33	Eczematoid dermatitis (HP:0000976)	3.07521254
34	Absent hair (HP:0002298)	3.06163730
35	Abnormality of the salivary glands (HP:0010286)	3.04192521
36	Sparse scalp hair (HP:0002209)	2.98270406
37	Hamartoma of the eye (HP:0010568)	2.79976536
38	Lack of skin elasticity (HP:0100679)	2.74451603
39	Pili torti (HP:0003777)	2.60702818
40	Furrowed tongue (HP:0000221)	2.59160346
41	Pustule (HP:0200039)	2.56280450
42	Abnormal hair laboratory examination (HP:0003328)	2.55762162
43	Hypergammaglobulinemia (HP:0010702)	2.47422768
44	Blepharitis (HP:0000498)	2.34643107
45	Natal tooth (HP:0000695)	2.26180897
46	Laryngomalacia (HP:0001601)	2.25119673
47	Hyperhidrosis (HP:0000975)	2.22917278
48	Dehydration (HP:0001944)	2.18806372
49	Slow-growing hair (HP:0002217)	2.16296107
50	Abnormality of hair growth rate (HP:0011363)	2.16296107
51	Brittle hair (HP:0002299)	2.15597060
52	Hypoplastic labia majora (HP:0000059)	2.14281839
53	Autoamputation (HP:0001218)	2.03373302
54	Amniotic constriction ring (HP:0009775)	2.00526318
55	Abnormality of placental membranes (HP:0011409)	2.00526318
56	Milia (HP:0001056)	2.00368504
57	Abnormality of nail color (HP:0100643)	12.3598687
58	Advanced eruption of teeth (HP:0006288)	1.97109695
59	Abnormality of the labia majora (HP:0012881)	1.94794399
60	Melanocytic nevus (HP:0000995)	1.87090601
61	Ridged nail (HP:0001807)	1.86333932
62	Selective tooth agenesis (HP:0001592)	1.84789212
63	Dry skin (HP:0000958)	1.84020552
64	Sepsis (HP:0100806)	1.81588269
65	Anonychia (HP:0001798)	1.80870400
66	Split foot (HP:0001839)	1.80864272
67	Multifactorial inheritance (HP:0001426)	1.78086470
68	Paralysis (HP:0003470)	1.77747937
69	Urticaria (HP:0001025)	1.75426328
70	Curly hair (HP:0002212)	1.71360255
71	Skin ulcer (HP:0200042)	1.70557406
72	Acanthosis nigricans (HP:0000956)	1.69974443
73	Corneal dystrophy (HP:0001131)	1.69731581
74	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.69632820
75	Recurrent corneal erosions (HP:0000495)	1.66911483
76	Duplicated collecting system (HP:0000081)	1.66834460
77	Conical tooth (HP:0000698)	1.59442832
78	Axonal loss (HP:0003447)	1.58988871
79	Septate vagina (HP:0001153)	1.57557185
80	Carious teeth (HP:0000670)	1.56060285
81	Hamartoma (HP:0010566)	1.55389201
82	Fine hair (HP:0002213)	1.54907889
83	Xerostomia (HP:0000217)	1.54293778
84	Taurodontia (HP:0000679)	1.51295026
85	Abnormality of permanent molar morphology (HP:0011071)	1.51295026
86	Abnormality of the dental root (HP:0006486)	1.51295026
87	Depressed nasal tip (HP:0000437)	1.50426758
88	Nasolacrimal duct obstruction (HP:0000579)	1.50376418
89	Verrucae (HP:0200043)	1.49829333
90	Papilloma (HP:0012740)	1.49829333
91	Dry hair (HP:0011359)	1.48871245
92	Segmental peripheral demyelination/remyelination (HP:0003481)	1.45247256
93	Abnormality of the fingernails (HP:0001231)	1.44319360
94	Abnormality of molar morphology (HP:0011070)	1.42525479
95	Abnormality of molar (HP:0011077)	1.42525479
96	Abnormality of the renal collecting system (HP:0004742)	1.41530343
97	Ventricular tachycardia (HP:0004756)	1.37489953
98	Anhidrosis (HP:0000970)	1.35929455
99	Oligodontia (HP:0000677)	1.35420936
100	Abnormality of the dental pulp (HP:0006479)	1.34483549

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	5.60870968
2	TGFBR1	5.48104046
3	STK24	4.25601413
4	MAP3K6	3.45975396
5	FGFR1	3.34627871
6	FER	3.20804785
7	SGK494	2.80441631
8	SGK223	2.80441631
9	EEF2K	2.69832349
10	MAPKAPK3	2.56588567
11	MAP3K9	2.50704348
12	MAP3K2	2.10253045
13	RIPK1	1.95369143
14	FGFR3	1.88067197
15	MAP3K3	1.87438125
16	LATS1	1.68831515
17	ERN1	1.67455674
18	EPHA3	1.65625727
19	IRAK1	1.54321066
20	PIK3CG	1.42855388
21	WNK1	1.36868957
22	TRPM7	1.33250133
23	MST1R	1.31442370
24	MET	1.25891108
25	MAPK7	1.25444891
26	EPHB1	1.22464156
27	MAP3K1	1.21076574
28	GRK6	1.13247371
29	IKBKB	1.10622870
30	AKT3	1.09333111
31	MAP2K6	1.08755225
32	STK3	1.08386489
33	SGK2	1.05309633
34	STK38L	1.02200969
35	PTK2	1.01926290
36	MAPKAPK5	0.99974602
37	MAPK12	0.99516522
38	TGFBR2	0.99460407
39	LATS2	0.95956226
40	MARK2	0.94988692
41	ADRBK1	0.91390655
42	PRPF4B	0.91215002
43	ABL2	0.89383159
44	IRAK2	0.88949717
45	PIM2	0.88720834
46	GSK3A	0.87209888
47	SGK3	0.83695507
48	MAP3K7	0.80757417
49	CDK12	0.80344487
50	TAOK1	0.77692558
51	NLK	0.76865720
52	RPS6KB1	0.75853645
53	FGFR2	0.66579902
54	IKBKE	0.64802531
55	SGK1	0.64663339
56	MTOR	0.62027020
57	IRAK4	0.61639121
58	RPS6KB2	0.60394534
59	PDGFRB	0.60338172
60	MAPKAPK2	0.58767948
61	PDGFRA	0.58419715
62	MAP3K12	0.57901360
63	MST4	0.57741541
64	PKN1	0.56275697
65	PRKAA2	0.53735663
66	DMPK	0.53017903
67	PRKD2	0.49324707
68	MOS	0.49053341
69	STK38	0.48095941
70	KIT	0.47532237
71	BMX	0.46328295
72	TAOK3	0.44223956
73	CDK6	0.42890663
74	MAP2K4	0.42038230
75	EPHB2	0.40508161
76	FGFR4	0.39765544
77	PRKCE	0.38965933
78	GRK7	0.38167357
79	MAPK4	0.34973241
80	ABL1	0.33555781
81	EPHA4	0.32681150
82	LRRK2	0.32514818
83	MAP3K5	0.32376620
84	JAK3	0.30430321
85	RET	0.29880950
86	MAPK15	0.28609130
87	KSR2	0.27982842
88	PAK2	0.27838204
89	HCK	0.27668738
90	BCR	0.27052235
91	STK10	0.24480983
92	MINK1	0.23206642
93	PBK	0.22647033
94	DYRK3	0.21695803
95	MAPK9	0.21250529
96	IRAK3	0.20762212
97	BRD4	0.20025016
98	CHUK	0.19994028
99	DYRK1B	0.19532123
100	TYRO3	0.18969600

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	6.85720997
2	Linoleic acid metabolism_Homo sapiens_hsa00591	5.36701163
3	Ether lipid metabolism_Homo sapiens_hsa00565	3.78575531
4	Arachidonic acid metabolism_Homo sapiens_hsa00590	3.52856133
5	Sphingolipid metabolism_Homo sapiens_hsa00600	2.68628727
6	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.51505012
7	GnRH signaling pathway_Homo sapiens_hsa04912	2.27455898
8	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	2.05536439
9	Phototransduction_Homo sapiens_hsa04744	1.97484923
10	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.95962845
11	Circadian rhythm_Homo sapiens_hsa04710	1.90257351
12	VEGF signaling pathway_Homo sapiens_hsa04370	1.83905186
13	Histidine metabolism_Homo sapiens_hsa00340	1.78502019
14	Long-term depression_Homo sapiens_hsa04730	1.69245508
15	Fatty acid elongation_Homo sapiens_hsa00062	1.69153593
16	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.67737524
17	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.51909602
18	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.49417610
19	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.45409056
20	Serotonergic synapse_Homo sapiens_hsa04726	1.32147867
21	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.29428272
22	Renin secretion_Homo sapiens_hsa04924	1.27185406
23	Ras signaling pathway_Homo sapiens_hsa04014	1.22636519
24	Choline metabolism in cancer_Homo sapiens_hsa05231	1.21171384
25	Amoebiasis_Homo sapiens_hsa05146	1.10647612
26	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.09799614
27	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.06735358
28	ABC transporters_Homo sapiens_hsa02010	1.01066791
29	Fat digestion and absorption_Homo sapiens_hsa04975	0.98137508
30	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.97523995
31	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.92510524
32	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.92134165
33	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.92068488
34	Glioma_Homo sapiens_hsa05214	0.86401940
35	Platelet activation_Homo sapiens_hsa04611	0.83426358
36	p53 signaling pathway_Homo sapiens_hsa04115	0.83034915
37	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.82861158
38	Pertussis_Homo sapiens_hsa05133	0.80484985
39	Acute myeloid leukemia_Homo sapiens_hsa05221	0.80120364
40	Phenylalanine metabolism_Homo sapiens_hsa00360	0.77866668
41	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.76138465
42	Retinol metabolism_Homo sapiens_hsa00830	0.75476563
43	Melanogenesis_Homo sapiens_hsa04916	0.74900526
44	Long-term potentiation_Homo sapiens_hsa04720	0.70924784
45	MicroRNAs in cancer_Homo sapiens_hsa05206	0.68277038
46	Glutamatergic synapse_Homo sapiens_hsa04724	0.67679480
47	Adherens junction_Homo sapiens_hsa04520	0.65970577
48	Estrogen signaling pathway_Homo sapiens_hsa04915	0.65816374
49	Gastric acid secretion_Homo sapiens_hsa04971	0.64630163
50	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.64583416
51	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.63905860
52	Pancreatic secretion_Homo sapiens_hsa04972	0.59402787
53	ECM-receptor interaction_Homo sapiens_hsa04512	0.57877796
54	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.56533285
55	Renal cell carcinoma_Homo sapiens_hsa05211	0.56050319
56	MAPK signaling pathway_Homo sapiens_hsa04010	0.55700928
57	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.55040402
58	Tight junction_Homo sapiens_hsa04530	0.54991670
59	Tuberculosis_Homo sapiens_hsa05152	0.52743305
60	Salivary secretion_Homo sapiens_hsa04970	0.52285861
61	Endocytosis_Homo sapiens_hsa04144	0.51349632
62	Rap1 signaling pathway_Homo sapiens_hsa04015	0.47654204
63	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.47246017
64	Bladder cancer_Homo sapiens_hsa05219	0.46843133
65	Thyroid cancer_Homo sapiens_hsa05216	0.42496192
66	Insulin signaling pathway_Homo sapiens_hsa04910	0.42119170
67	Circadian entrainment_Homo sapiens_hsa04713	0.41283150
68	ErbB signaling pathway_Homo sapiens_hsa04012	0.41085808
69	PPAR signaling pathway_Homo sapiens_hsa03320	0.41018573
70	Amphetamine addiction_Homo sapiens_hsa05031	0.39788805
71	Notch signaling pathway_Homo sapiens_hsa04330	0.39448508
72	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.38545575
73	Hepatitis C_Homo sapiens_hsa05160	0.36183365
74	Proteoglycans in cancer_Homo sapiens_hsa05205	0.35578825
75	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.35147726
76	beta-Alanine metabolism_Homo sapiens_hsa00410	0.35016081
77	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.33874209
78	Collecting duct acid secretion_Homo sapiens_hsa04966	0.33808073
79	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.33717424
80	Glucagon signaling pathway_Homo sapiens_hsa04922	0.33637777
81	Toxoplasmosis_Homo sapiens_hsa05145	0.32365543
82	Axon guidance_Homo sapiens_hsa04360	0.32034257
83	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.31350014
84	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.30998709
85	Calcium signaling pathway_Homo sapiens_hsa04020	0.29640207
86	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.28858392
87	Arginine biosynthesis_Homo sapiens_hsa00220	0.28565664
88	Olfactory transduction_Homo sapiens_hsa04740	0.27319058
89	Hippo signaling pathway_Homo sapiens_hsa04390	0.27224822
90	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.26825532
91	cAMP signaling pathway_Homo sapiens_hsa04024	0.26598543
92	Pathways in cancer_Homo sapiens_hsa05200	0.25715062
93	Dopaminergic synapse_Homo sapiens_hsa04728	0.25593376
94	Nitrogen metabolism_Homo sapiens_hsa00910	0.25551615
95	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.25096286
96	Mineral absorption_Homo sapiens_hsa04978	0.23513066
97	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.23059805
98	Salmonella infection_Homo sapiens_hsa05132	0.22477243
99	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.22187626
100	Influenza A_Homo sapiens_hsa05164	0.22137049

LCE2D

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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