LCE3E

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)9.10132128
2keratinocyte differentiation (GO:0030216)8.91569333
3desmosome organization (GO:0002934)8.76119788
4molting cycle (GO:0042303)8.31153097
5hair cycle (GO:0042633)8.31153097
6multicellular organismal water homeostasis (GO:0050891)8.16208552
7positive regulation of interleukin-8 secretion (GO:2000484)8.06355573
8regulation of transforming growth factor beta1 production (GO:0032908)7.42845444
9positive regulation of humoral immune response (GO:0002922)7.08821998
10positive regulation of glomerulus development (GO:0090193)7.03701716
11defense response to Gram-negative bacterium (GO:0050829)6.84473132
12long-chain fatty acid biosynthetic process (GO:0042759)6.78500276
13water homeostasis (GO:0030104)6.75536323
14epidermal cell differentiation (GO:0009913)6.46108019
15detection of bacterium (GO:0016045)6.26343340
16hemidesmosome assembly (GO:0031581)6.01994838
17sarcoplasmic reticulum calcium ion transport (GO:0070296)5.98432998
18defense response to fungus (GO:0050832)5.96093145
19positive regulation of p38MAPK cascade (GO:1900745)5.91329854
20regulation of cell proliferation involved in kidney development (GO:1901722)5.90477392
21regulation of keratinocyte differentiation (GO:0045616)5.90389311
22antimicrobial humoral response (GO:0019730)5.81970987
23regulation of cellular amide metabolic process (GO:0034248)5.74108468
24detection of other organism (GO:0098543)5.72315774
25positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)5.68783222
26regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)5.68783222
27bundle of His cell to Purkinje myocyte communication (GO:0086069)5.68707176
28negative regulation of interleukin-17 production (GO:0032700)5.55215265
29linoleic acid metabolic process (GO:0043651)5.53849181
30regulation of interleukin-8 secretion (GO:2000482)5.42225818
31positive regulation of T-helper 1 type immune response (GO:0002827)5.30899571
32skin morphogenesis (GO:0043589)5.22783499
33epidermis development (GO:0008544)5.09860483
34phosphatidylserine acyl-chain remodeling (GO:0036150)5.04199075
35negative regulation of interferon-gamma production (GO:0032689)4.99746952
36intermediate filament organization (GO:0045109)4.95702919
37regulation of natural killer cell differentiation (GO:0032823)4.86755619
38phosphatidylinositol acyl-chain remodeling (GO:0036149)4.85080491
39regulation of toll-like receptor 4 signaling pathway (GO:0034143)4.66969702
40muscle organ morphogenesis (GO:0048644)4.56972093
41response to vitamin A (GO:0033189)4.56250501
42phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.51130811
43regulation of glomerulus development (GO:0090192)4.51017984
44coronary vasculature morphogenesis (GO:0060977)4.47609636
45regulation of secondary heart field cardioblast proliferation (GO:0003266)4.44994570
46regulation of cardioblast proliferation (GO:0003264)4.44994570
47regulation of skeletal muscle contraction (GO:0014819)4.39493925
48lipoxygenase pathway (GO:0019372)4.37819049
49actin-myosin filament sliding (GO:0033275)4.33598415
50muscle filament sliding (GO:0030049)4.33598415
51chemical homeostasis within a tissue (GO:0048875)4.32390446
52phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.31522183
53regulation of skeletal muscle cell differentiation (GO:2001014)4.30101318
54lymph vessel development (GO:0001945)4.28864830
55regulation of p38MAPK cascade (GO:1900744)4.26217117
56ectoderm development (GO:0007398)4.24516313
57skeletal muscle contraction (GO:0003009)4.24209797
58positive regulation of transforming growth factor beta production (GO:0071636)4.21849250
59positive regulation of epidermis development (GO:0045684)4.17357275
60positive regulation of cholesterol efflux (GO:0010875)4.13661159
61antibacterial humoral response (GO:0019731)4.11093688
62outer ear morphogenesis (GO:0042473)4.10681292
63response to fungus (GO:0009620)4.10486798
64tooth mineralization (GO:0034505)4.08285478
65regulation of relaxation of muscle (GO:1901077)4.07298659
66phosphatidylcholine acyl-chain remodeling (GO:0036151)4.03574310
67activation of MAPKKK activity (GO:0000185)3.95302634
68positive regulation of response to biotic stimulus (GO:0002833)3.88820034
69regulation of MHC class I biosynthetic process (GO:0045343)3.84884049
70regulation of epidermal cell differentiation (GO:0045604)3.84665265
71natural killer cell activation involved in immune response (GO:0002323)3.80891782
72phospholipid efflux (GO:0033700)3.80354120
73regulation of T-helper 1 type immune response (GO:0002825)3.79055085
74ceramide biosynthetic process (GO:0046513)3.75894267
75dendritic cell migration (GO:0036336)3.74591805
76positive regulation of cholesterol transport (GO:0032376)3.70240334
77positive regulation of sterol transport (GO:0032373)3.70240334
78purine nucleotide salvage (GO:0032261)3.67859939
79nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.60596420
80actin-mediated cell contraction (GO:0070252)3.54301356
81intermediate filament cytoskeleton organization (GO:0045104)3.53480612
82fatty acid elongation (GO:0030497)3.50167840
83intermediate filament-based process (GO:0045103)3.45355016
84positive regulation of meiotic cell cycle (GO:0051446)3.42650693
85positive regulation of keratinocyte differentiation (GO:0045618)3.34871929
86regulation of neuron projection regeneration (GO:0070570)3.33973353
87regulation of axon regeneration (GO:0048679)3.33973353
88positive regulation of epidermal cell differentiation (GO:0045606)3.32694453
89virion attachment to host cell (GO:0019062)3.29784811
90adhesion of symbiont to host cell (GO:0044650)3.29784811
91glucosamine-containing compound catabolic process (GO:1901072)3.27593305
92cellular response to retinoic acid (GO:0071300)3.25490815
93detection of external biotic stimulus (GO:0098581)3.25346058
94innate immune response in mucosa (GO:0002227)3.22861261
95regulation of hair cycle (GO:0042634)3.22073153
96defense response to Gram-positive bacterium (GO:0050830)3.17656380
97negative regulation of meiotic cell cycle (GO:0051447)3.15213508
98muscle cell fate commitment (GO:0042693)3.14667187
99embryonic viscerocranium morphogenesis (GO:0048703)3.14090341
100cellular response to arsenic-containing substance (GO:0071243)3.12896148
101skin development (GO:0043588)3.12808436
102cellular response to epidermal growth factor stimulus (GO:0071364)3.09280695
103myotube differentiation (GO:0014902)3.08006296
104skeletal muscle adaptation (GO:0043501)3.07379457
105keratinocyte development (GO:0003334)3.07277297
106phosphatidylserine metabolic process (GO:0006658)3.06922629
107branching involved in labyrinthine layer morphogenesis (GO:0060670)3.06287923
108regulation of epidermis development (GO:0045682)3.05826906
109hair cell differentiation (GO:0035315)3.03748342
110negative regulation of toll-like receptor signaling pathway (GO:0034122)3.03196022
111positive regulation of interleukin-6 production (GO:0032755)3.02467031
112* keratinization (GO:0031424)26.2160048
113regulation of collagen biosynthetic process (GO:0032965)2.96024240
114positive regulation of monocyte chemotaxis (GO:0090026)2.95967909
115plasma membrane repair (GO:0001778)2.95391072
116positive regulation of myotube differentiation (GO:0010831)2.94642411
117fibrinolysis (GO:0042730)2.93262424
118regulation of interleukin-17 production (GO:0032660)2.92115334
119bile acid and bile salt transport (GO:0015721)2.90241017
120actin filament-based movement (GO:0030048)2.88866697
121creatine metabolic process (GO:0006600)2.85555380
122regulation of transforming growth factor beta production (GO:0071634)2.84106604
123ventricular cardiac muscle cell action potential (GO:0086005)2.82571975
124defense response to bacterium (GO:0042742)2.76753533
125gap junction assembly (GO:0016264)2.76009062
126detection of biotic stimulus (GO:0009595)2.74657826
127positive regulation of collagen biosynthetic process (GO:0032967)2.72489639
128regulation of interleukin-6 production (GO:0032675)2.69454382
129adhesion of symbiont to host (GO:0044406)2.66266504
130positive regulation of vasculogenesis (GO:2001214)2.63789891
131surfactant homeostasis (GO:0043129)2.61559977
132early endosome to late endosome transport (GO:0045022)2.61142761
133regulation of cholesterol efflux (GO:0010874)2.59361801
134positive regulation of collagen metabolic process (GO:0010714)2.57798582
135Peyers patch development (GO:0048541)2.57529830
136mucosal-associated lymphoid tissue development (GO:0048537)2.57529830
137sequestering of metal ion (GO:0051238)2.56925682
138long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.56311278
139positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.55244400
140response to epidermal growth factor (GO:0070849)2.52615071
141striated muscle contraction (GO:0006941)2.52268200
142negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.51979133
143primary alcohol catabolic process (GO:0034310)2.51462862
144positive regulation of skeletal muscle tissue development (GO:0048643)2.51249348
145mucosal immune response (GO:0002385)2.51234405
146cellular response to glucocorticoid stimulus (GO:0071385)2.47819968
147skeletal muscle fiber development (GO:0048741)2.47019260
148fatty-acyl-CoA metabolic process (GO:0035337)2.46786061
149cranial nerve morphogenesis (GO:0021602)2.45476006
150regulation of penile erection (GO:0060405)2.41827390
151negative regulation of thymocyte apoptotic process (GO:0070244)2.41694616
152regulation of heart rate by cardiac conduction (GO:0086091)2.41220807
153negative regulation of cell fate specification (GO:0009996)2.40305679
154keratinocyte proliferation (GO:0043616)2.38299474
155cellular response to corticosteroid stimulus (GO:0071384)2.37983502
156epithelial cell differentiation (GO:0030855)2.36491818
157wound healing (GO:0042060)2.36407917
158organ or tissue specific immune response (GO:0002251)2.36300527
159cochlea morphogenesis (GO:0090103)2.34125776
160cell communication involved in cardiac conduction (GO:0086065)2.33168782
161negative regulation of calcium ion transmembrane transport (GO:1903170)2.32889556
162negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.32889556
163regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.31265083
164ethanol metabolic process (GO:0006067)2.30567488
165cytoskeletal anchoring at plasma membrane (GO:0007016)2.30167001
166epithelium development (GO:0060429)2.29875998
167histamine secretion (GO:0001821)2.26671115
168retinoic acid receptor signaling pathway (GO:0048384)2.25397723
169establishment of skin barrier (GO:0061436)14.0225163
170regulation of water loss via skin (GO:0033561)12.0601881
171peptide cross-linking (GO:0018149)11.9134985
172positive regulation of cellular amide metabolic process (GO:0034250)11.1193369
173cell wall macromolecule metabolic process (GO:0044036)10.1288984
174cell wall macromolecule catabolic process (GO:0016998)10.1288984

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF652_21678463_ChIP-ChIP_ZR75-1_Human6.10452927
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.32691321
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.08652268
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.81266740
5* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.55844367
6ESR1_21235772_ChIP-Seq_MCF-7_Human2.49746906
7ZNF263_19887448_ChIP-Seq_K562_Human2.34727540
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.17465357
9TP63_17297297_ChIP-ChIP_HaCaT_Human12.2055649
10ESR2_21235772_ChIP-Seq_MCF-7_Human1.96187598
11CTCF_20526341_ChIP-Seq_ESCs_Human1.91916701
12ERG_20517297_ChIP-Seq_VCAP_Human1.87230416
13SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.86935442
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.86704150
15RARG_19884340_ChIP-ChIP_MEFs_Mouse1.86054444
16ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.72398665
17* CTCF_27219007_Chip-Seq_Bcells_Human1.71793062
18SOX9_24532713_ChIP-Seq_HFSC_Mouse1.62733744
19SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.61674230
20SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.61674230
21* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.59748851
22RACK7_27058665_Chip-Seq_MCF-7_Human1.50365777
23EGR1_19032775_ChIP-ChIP_M12_Human1.50361516
24FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.49241923
25JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.46165482
26TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44962921
27* GATA6_21074721_ChIP-Seq_CACO-2_Human1.42974007
28ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.42879928
29BCOR_27268052_Chip-Seq_Bcells_Human1.42185524
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41439024
31TP53_18474530_ChIP-ChIP_U2OS_Human1.32695422
32SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.32354219
33KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.32279311
34BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.32263669
35CJUN_26792858_Chip-Seq_BT549_Human1.32152869
36FOXO3_23340844_ChIP-Seq_DLD1_Human1.30856985
37RXR_22108803_ChIP-Seq_LS180_Human1.29166454
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.28355923
39GATA3_24758297_ChIP-Seq_MCF-7_Human1.28161710
40TP63_22573176_ChIP-Seq_HFKS_Human1.27475239
41AUTS2_25519132_ChIP-Seq_293T-REX_Human1.25788471
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.24969387
43CLOCK_20551151_ChIP-Seq_293T_Human1.24179918
44DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22924869
45SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.21884374
46SOX2_20726797_ChIP-Seq_SW620_Human1.20770522
47TP63_23658742_ChIP-Seq_EP156T_Human1.20422661
48NANOG_20526341_ChIP-Seq_ESCs_Human1.20386855
49CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.18886463
50ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.17740855
51SUZ12_27294783_Chip-Seq_ESCs_Mouse1.15420034
52FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.14716627
53YY1_22570637_ChIP-Seq_MALME-3M_Human1.14566228
54TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14375844
55ATF3_27146783_Chip-Seq_COLON_Human1.14215395
56PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.14110338
57KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13401073
58UBF1/2_26484160_Chip-Seq_HMECs_Human1.13103907
59TCF4_18268006_ChIP-ChIP_LS174T_Human1.12096574
60ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11767791
61LXR_22292898_ChIP-Seq_THP-1_Human1.10740076
62RUNX1_27514584_Chip-Seq_MCF-7_Human1.10675976
63E2F1_20622854_ChIP-Seq_HELA_Human1.10661056
64ESR1_20079471_ChIP-ChIP_T-47D_Human1.09246649
65P68_20966046_ChIP-Seq_HELA_Human1.07118009
66HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06192379
67P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.06090240
68BCL6_27268052_Chip-Seq_Bcells_Human1.05306518
69SA1_27219007_Chip-Seq_ERYTHROID_Human1.04259518
70HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03489981
71PPAR_26484153_Chip-Seq_NCI-H1993_Human1.02635697
72SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02348286
73OCT1_27270436_Chip-Seq_PROSTATE_Human1.02265953
74SMC4_20622854_ChIP-Seq_HELA_Human1.02076871
75UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01287184
76CEBPB_22108803_ChIP-Seq_LS180_Human1.00707520
77FOXH1_21741376_ChIP-Seq_ESCs_Human1.00287451
78TBX20_22080862_ChIP-Seq_HEART_Mouse0.96889835
79TBX20_22328084_ChIP-Seq_HEART_Mouse0.96889835
80SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.96146057
81AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.95906184
82GATA4_25053715_ChIP-Seq_YYC3_Human0.94645404
83KLF5_25053715_ChIP-Seq_YYC3_Human0.92158820
84MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.90574440
85SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.89621938
86PPARA_22158963_ChIP-Seq_LIVER_Mouse0.89051170
87ELK3_25401928_ChIP-Seq_HUVEC_Human0.88931263
88ZNF217_24962896_ChIP-Seq_MCF-7_Human0.88927279
89KDM2B_26808549_Chip-Seq_DND41_Human0.88480356
90TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88261192
91RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.87900148
92RXR_22158963_ChIP-Seq_LIVER_Mouse0.87335562
93CSB_26484114_Chip-Seq_FIBROBLAST_Human0.87135949
94JARID2_20075857_ChIP-Seq_MESCs_Mouse0.86878811
95RAC3_21632823_ChIP-Seq_H3396_Human0.86077083
96STAT6_21828071_ChIP-Seq_BEAS2B_Human0.85000809
97TAF2_19829295_ChIP-Seq_ESCs_Human0.84429226
98EZH2_27294783_Chip-Seq_ESCs_Mouse0.83987521
99VDR_22108803_ChIP-Seq_LS180_Human0.83348381
100RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.82845716
101CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.82806398
102TP53_16413492_ChIP-PET_HCT116_Human0.82632283
103CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.81862065
104ERG_21242973_ChIP-ChIP_JURKAT_Human0.81831527
105P53_21459846_ChIP-Seq_SAOS-2_Human0.81546768
106NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.81455420
107SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.80666807
108P300_27058665_Chip-Seq_ZR-75-30cells_Human0.80235051
109THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.78851964
110TP53_20018659_ChIP-ChIP_R1E_Mouse0.77553100
111BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.77471633
112GATA3_21878914_ChIP-Seq_MCF-7_Human0.77164030
113EGR1_19374776_ChIP-ChIP_THP-1_Human0.77003001
114PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.75758974
115BCAT_22108803_ChIP-Seq_LS180_Human0.75477935
116STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.75476316
117VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.75262903
118EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.74494681
119GATA1_22025678_ChIP-Seq_K562_Human0.74348206
120CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.73369698
121RBPJ_21746931_ChIP-Seq_IB4_Human0.73143737
122EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.72665007
123TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.72172644
124ZFP281_18757296_ChIP-ChIP_E14_Mouse0.71842940
125GATA6_25053715_ChIP-Seq_YYC3_Human0.71540923
126* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.71305059
127JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71048586
128HNFA_21074721_ChIP-Seq_CACO-2_Human0.71014131
129NRF2_20460467_ChIP-Seq_MEFs_Mouse0.70944433
130NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.70944433
131PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.68382335
132GATA3_21867929_ChIP-Seq_TH1_Mouse0.67926043
133SMAD4_21741376_ChIP-Seq_ESCs_Human0.66799337
134Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.66347935
135FOXA1_25552417_ChIP-Seq_VCAP_Human0.64805566
136BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.64493225
137NCOR_22424771_ChIP-Seq_293T_Human0.62879159

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier8.71159531
2MP0005275_abnormal_skin_tensile7.14596408
3MP0005501_abnormal_skin_physiology5.24145699
4MP0000579_abnormal_nail_morphology5.03301190
5MP0000467_abnormal_esophagus_morphology3.80712664
6MP0002234_abnormal_pharynx_morphology3.58309444
7MP0010234_abnormal_vibrissa_follicle3.35336028
8MP0003705_abnormal_hypodermis_morpholog3.33341017
9MP0000762_abnormal_tongue_morphology2.87088977
10MP0001216_abnormal_epidermal_layer2.85385422
11MP0004947_skin_inflammation2.82355678
12MP0010771_integument_phenotype2.71826947
13MP0000647_abnormal_sebaceous_gland2.46715155
14MP0000751_myopathy2.38870860
15MP0002060_abnormal_skin_morphology2.31477489
16MP0000383_abnormal_hair_follicle2.19304956
17MP0001243_abnormal_dermal_layer2.14549107
18MP0001188_hyperpigmentation2.08374826
19MP0010678_abnormal_skin_adnexa2.03536975
20MP0002095_abnormal_skin_pigmentation2.00366183
21MP0003646_muscle_fatigue1.94937235
22MP0003453_abnormal_keratinocyte_physiol1.94008596
23MP0000427_abnormal_hair_cycle1.92248795
24MP0000749_muscle_degeneration1.92125379
25MP0002254_reproductive_system_inflammat1.85323654
26MP0004185_abnormal_adipocyte_glucose1.84427366
27MP0003941_abnormal_skin_development1.80519230
28MP0000377_abnormal_hair_follicle1.80424267
29MP0004885_abnormal_endolymph1.75222160
30MP0005377_hearing/vestibular/ear_phenot1.72589124
31MP0003878_abnormal_ear_physiology1.72589124
32MP0005451_abnormal_body_composition1.71479764
33MP0002098_abnormal_vibrissa_morphology1.69562165
34MP0004381_abnormal_hair_follicle1.64173880
35MP0003011_delayed_dark_adaptation1.54950212
36MP0009931_abnormal_skin_appearance1.53604955
37MP0003566_abnormal_cell_adhesion1.46346708
38MP0001191_abnormal_skin_condition1.40400201
39MP0002837_dystrophic_cardiac_calcinosis1.36755885
40MP0000747_muscle_weakness1.35332358
41MP0003191_abnormal_cellular_cholesterol1.34797725
42MP0000367_abnormal_coat/_hair1.28412724
43MP0004264_abnormal_extraembryonic_tissu1.26508143
44MP0000759_abnormal_skeletal_muscle1.15584187
45MP0000678_abnormal_parathyroid_gland1.13417766
46MP0002106_abnormal_muscle_physiology1.12678882
47MP0004145_abnormal_muscle_electrophysio1.12447312
48MP0004130_abnormal_muscle_cell1.04167573
49MP0001879_abnormal_lymphatic_vessel1.02974311
50MP0004087_abnormal_muscle_fiber1.01874542
51MP0000733_abnormal_muscle_development0.99693612
52MP0000750_abnormal_muscle_regeneration0.95002318
53MP0008004_abnormal_stomach_pH0.91027206
54MP0005666_abnormal_adipose_tissue0.90801738
55MP0004036_abnormal_muscle_relaxation0.89880006
56MP0001851_eye_inflammation0.88322164
57MP0000465_gastrointestinal_hemorrhage0.87578244
58MP0005369_muscle_phenotype0.86599424
59MP0003656_abnormal_erythrocyte_physiolo0.84563435
60MP0003950_abnormal_plasma_membrane0.82798845
61MP0004043_abnormal_pH_regulation0.82594418
62MP0005620_abnormal_muscle_contractility0.79615279
63MP0000566_synostosis0.78543289
64MP0001784_abnormal_fluid_regulation0.77365665
65MP0003252_abnormal_bile_duct0.76978687
66MP0009697_abnormal_copulation0.76091185
67MP0004272_abnormal_basement_membrane0.75868502
68MP0002332_abnormal_exercise_endurance0.71836739
69MP0000371_diluted_coat_color0.71418061
70MP0002249_abnormal_larynx_morphology0.70347784
71MP0005409_darkened_coat_color0.69779224
72MP0002177_abnormal_outer_ear0.68177964
73MP0002269_muscular_atrophy0.67792086
74MP0004782_abnormal_surfactant_physiolog0.67053534
75MP0003221_abnormal_cardiomyocyte_apopto0.65736242
76MP0000470_abnormal_stomach_morphology0.62481936
77MP0008438_abnormal_cutaneous_collagen0.61992110
78MP0005330_cardiomyopathy0.61180885
79MP0010030_abnormal_orbit_morphology0.59699908
80MP0001849_ear_inflammation0.58971217
81MP0001958_emphysema0.58343522
82MP0002972_abnormal_cardiac_muscle0.57900401
83MP0005023_abnormal_wound_healing0.57383684
84MP0005375_adipose_tissue_phenotype0.57205826
85MP0004270_analgesia0.53375710
86MP0003755_abnormal_palate_morphology0.53342857
87MP0009053_abnormal_anal_canal0.52887642
88MP0001186_pigmentation_phenotype0.51387193
89MP0001346_abnormal_lacrimal_gland0.49758549
90MP0001340_abnormal_eyelid_morphology0.49219050
91MP0004084_abnormal_cardiac_muscle0.49173094
92MP0003329_amyloid_beta_deposits0.48359129
93MP0002127_abnormal_cardiovascular_syste0.46339070
94MP0001177_atelectasis0.43310651
95MP0009840_abnormal_foam_cell0.43159325
96MP0010368_abnormal_lymphatic_system0.41218427
97MP0009672_abnormal_birth_weight0.39352296
98MP0002075_abnormal_coat/hair_pigmentati0.35602206
99MP0001299_abnormal_eye_distance/0.35105834
100MP0000343_altered_response_to0.34548019
101MP0002136_abnormal_kidney_physiology0.34348801
102MP0003828_pulmonary_edema0.33920201
103MP0004510_myositis0.33587410
104MP0008057_abnormal_DNA_replication0.33494317
105MP0002971_abnormal_brown_adipose0.33362541
106MP0003315_abnormal_perineum_morphology0.33244432
107MP0010352_gastrointestinal_tract_polyps0.31840529
108MP0008961_abnormal_basal_metabolism0.31706973
109MP0000003_abnormal_adipose_tissue0.31525305
110MP0005266_abnormal_metabolism0.31355988
111MP0002138_abnormal_hepatobiliary_system0.31193724
112MP0010630_abnormal_cardiac_muscle0.30808360
113MP0008569_lethality_at_weaning0.30706832
114MP0004858_abnormal_nervous_system0.30546807
115MP0009333_abnormal_splenocyte_physiolog0.30371500
116MP0001544_abnormal_cardiovascular_syste0.30051317
117MP0005385_cardiovascular_system_phenoty0.30051317
118MP0005075_abnormal_melanosome_morpholog0.29634843
119MP0004197_abnormal_fetal_growth/weight/0.29442482
120MP0006138_congestive_heart_failure0.29329841
121MP0005388_respiratory_system_phenotype0.28103939
122MP0002133_abnormal_respiratory_system0.28103939
123MP0005193_abnormal_anterior_eye0.28044393
124MP0008995_early_reproductive_senescence0.27849580
125MP0001502_abnormal_circadian_rhythm0.26907182
126MP0003075_altered_response_to0.26755100
127MP0002108_abnormal_muscle_morphology0.25782575
128MP0002295_abnormal_pulmonary_circulatio0.24090068
129MP0002697_abnormal_eye_size0.22082338
130MP0008260_abnormal_autophagy0.20351402
131MP0009765_abnormal_xenobiotic_induced0.15979511
132MP0000627_abnormal_mammary_gland0.14817534
133MP0001756_abnormal_urination0.14724291
134MP0010386_abnormal_urinary_bladder0.13841817
135MP0005076_abnormal_cell_differentiation0.13233463
136MP0003638_abnormal_response/metabolism_0.12900657
137MP0002111_abnormal_tail_morphology0.10664949
138MP0001765_abnormal_ion_homeostasis0.08822128
139MP0001485_abnormal_pinna_reflex0.08709442
140MP0002069_abnormal_eating/drinking_beha0.07035522
141MP0009115_abnormal_fat_cell0.06916054
142MP0006072_abnormal_retinal_apoptosis0.05198574
143MP0000432_abnormal_head_morphology0.04767738
144MP0002081_perinatal_lethality0.04224895
145MP0005248_abnormal_Harderian_gland0.04043652
146MP0001286_abnormal_eye_development0.01808659
147MP0003436_decreased_susceptibility_to0.01616032
148MP0003186_abnormal_redox_activity0.01179549
149MP0008058_abnormal_DNA_repair0.01063405
150MP0003806_abnormal_nucleotide_metabolis0.00987015

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)9.61972285
2Parakeratosis (HP:0001036)9.14606856
3Abnormality of nail color (HP:0100643)7.80165057
4Conjunctival hamartoma (HP:0100780)6.58364902
5Palmoplantar hyperkeratosis (HP:0000972)5.67950012
6Palmar hyperkeratosis (HP:0010765)5.34478471
7Plantar hyperkeratosis (HP:0007556)5.24950302
8Hypotrichosis (HP:0001006)5.03996977
9Thick nail (HP:0001805)4.97149255
10Distal arthrogryposis (HP:0005684)4.86213384
11Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.81750305
12Muscle fiber inclusion bodies (HP:0100299)4.76668915
13Onycholysis (HP:0001806)4.76126642
14Right ventricular cardiomyopathy (HP:0011663)4.72450104
15Erythroderma (HP:0001019)4.65705540
16Congenital ichthyosiform erythroderma (HP:0007431)4.62224557
17Woolly hair (HP:0002224)4.43712397
18Nemaline bodies (HP:0003798)4.41876118
19Exercise-induced myalgia (HP:0003738)4.40243747
20Hamartoma of the eye (HP:0010568)4.31119250
21Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.29374820
22Pustule (HP:0200039)4.20467620
23Round ear (HP:0100830)4.16299089
24Erythema (HP:0010783)4.06899986
25Type 1 muscle fiber predominance (HP:0003803)4.00088742
26Increased connective tissue (HP:0009025)3.89235469
27Gangrene (HP:0100758)3.84778528
28Pili torti (HP:0003777)3.84678942
29Ulnar deviation of the wrist (HP:0003049)3.72866909
30Myopathic facies (HP:0002058)3.60518991
31Difficulty running (HP:0009046)3.54334548
32Hyporeflexia of lower limbs (HP:0002600)3.47211780
33Exercise-induced muscle cramps (HP:0003710)3.38350381
34Calcaneovalgus deformity (HP:0001848)3.33163051
35Alopecia of scalp (HP:0002293)3.32826345
36Absent phalangeal crease (HP:0006109)3.25406674
37Palmoplantar keratoderma (HP:0000982)3.22507807
38Abnormal blistering of the skin (HP:0008066)3.21780211
39Abnormality of secondary sexual hair (HP:0009888)3.20564847
40Abnormality of the axillary hair (HP:0100134)3.20564847
41Follicular hyperkeratosis (HP:0007502)3.17272913
42Muscle fiber splitting (HP:0003555)3.15589321
43Ectropion (HP:0000656)3.08398595
44Corneal erosion (HP:0200020)3.04142237
45Muscle hypertrophy of the lower extremities (HP:0008968)3.03098063
46Unilateral renal agenesis (HP:0000122)3.02113122
47Fragile nails (HP:0001808)2.99922804
48Sparse scalp hair (HP:0002209)2.97871990
49Corneal dystrophy (HP:0001131)2.96915386
50Hyperhidrosis (HP:0000975)2.96327717
51Calf muscle hypertrophy (HP:0008981)2.93951415
52Deformed tarsal bones (HP:0008119)2.93290977
53Furrowed tongue (HP:0000221)2.93200423
54Myoglobinuria (HP:0002913)2.83436421
55Dehydration (HP:0001944)2.81865222
56Milia (HP:0001056)2.76903844
57Hypergammaglobulinemia (HP:0010702)2.76139365
58Eczematoid dermatitis (HP:0000976)2.69936406
59Distal lower limb muscle weakness (HP:0009053)2.67361409
60Abnormal finger flexion creases (HP:0006143)2.65956361
61Increased variability in muscle fiber diameter (HP:0003557)2.64159840
62Paralysis (HP:0003470)2.59181645
63Brittle hair (HP:0002299)2.57742935
64Abnormality of skeletal muscle fiber size (HP:0012084)2.57655757
65Nail dystrophy (HP:0008404)2.57602328
66Congenital malformation of the right heart (HP:0011723)2.54536314
67Double outlet right ventricle (HP:0001719)2.54536314
68Rimmed vacuoles (HP:0003805)2.51512059
69Villous atrophy (HP:0011473)2.44585412
70Abnormality of small intestinal villus morphology (HP:0011472)2.44585412
71Absent eyelashes (HP:0000561)2.44202296
72Pruritus (HP:0000989)2.39551890
73Natal tooth (HP:0000695)2.38238251
74Hypohidrosis (HP:0000966)2.38003818
75Autoimmune thrombocytopenia (HP:0001973)2.36771471
76Abnormality of the salivary glands (HP:0010286)2.35537359
77Sparse eyelashes (HP:0000653)2.32712036
78Abnormal hair laboratory examination (HP:0003328)2.29564158
79Absent hair (HP:0002298)2.29438256
80Distal lower limb amyotrophy (HP:0008944)2.28681294
81Neck muscle weakness (HP:0000467)2.24555961
82Ventricular tachycardia (HP:0004756)2.20215830
83Urticaria (HP:0001025)2.18545456
84Areflexia of lower limbs (HP:0002522)2.18507512
85EMG: myopathic abnormalities (HP:0003458)2.18497063
86Abnormality of the aortic arch (HP:0012303)2.17885003
87Abnormality of the calf musculature (HP:0001430)2.13789368
88Mesangial abnormality (HP:0001966)2.11253149
89Sepsis (HP:0100806)2.10865570
90Verrucae (HP:0200043)2.10434598
91Papilloma (HP:0012740)2.10434598
92Frequent falls (HP:0002359)2.10203590
93Abnormality of the parathyroid morphology (HP:0011766)2.08783243
94Abnormality of placental membranes (HP:0011409)2.06706232
95Amniotic constriction ring (HP:0009775)2.06706232
96Abnormality of the calcaneus (HP:0008364)2.04071414
97Difficulty climbing stairs (HP:0003551)2.03947587
98Hyperthyroidism (HP:0000836)2.03379897
99Anonychia (HP:0001798)2.02263203
100Muscle stiffness (HP:0003552)2.00972341
101Laryngomalacia (HP:0001601)2.00586141
102Oral leukoplakia (HP:0002745)10.8878949
103Advanced eruption of teeth (HP:0006288)1.99103630
104Lack of skin elasticity (HP:0100679)1.98908428
105Cholelithiasis (HP:0001081)1.98069054
106Dry skin (HP:0000958)1.95373984
107Autoimmune hemolytic anemia (HP:0001890)1.95049328
108Fatigable weakness (HP:0003473)1.93131692
109Abnormality of the neuromuscular junction (HP:0003398)1.93131692
110Myotonia (HP:0002486)1.92053493
111Autoamputation (HP:0001218)1.90928288
112Rhabdomyolysis (HP:0003201)1.83694797
113Facial diplegia (HP:0001349)1.82349334
114Carious teeth (HP:0000670)1.82143918
115Acanthosis nigricans (HP:0000956)1.81979354
116Blepharitis (HP:0000498)1.80455690
117Abnormal gallbladder morphology (HP:0012437)1.78335852
118Scapular winging (HP:0003691)1.78077539
119Lower limb amyotrophy (HP:0007210)1.75191725
120Sudden death (HP:0001699)1.73925130
121Achilles tendon contracture (HP:0001771)1.72946951
122Lip pit (HP:0100267)1.69010934
123Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.67515336
124Malignant hyperthermia (HP:0002047)1.66065387
125Dry hair (HP:0011359)1.64951109
126Skin ulcer (HP:0200042)1.64624463
127Tetany (HP:0001281)1.63889697
128Abnormality of the Achilles tendon (HP:0005109)1.61935984
129Hypoplastic left heart (HP:0004383)1.61705546
130Hamartoma (HP:0010566)1.60678728
131Multifactorial inheritance (HP:0001426)1.59168106
132Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.58232580
133Abnormality of the fingernails (HP:0001231)1.55599147
134Everted lower lip vermilion (HP:0000232)1.46683669
135Epidermoid cyst (HP:0200040)1.39254989
136Asthma (HP:0002099)1.37379915
137Fine hair (HP:0002213)1.36447005
138Popliteal pterygium (HP:0009756)1.36267678
139Hypoplastic labia majora (HP:0000059)1.34432231
140Premature ovarian failure (HP:0008209)1.33429108
141Curly hair (HP:0002212)1.31259881
142Ridged nail (HP:0001807)1.30546609
143Recurrent corneal erosions (HP:0000495)1.28985827
144Abnormality of the labia majora (HP:0012881)1.21362748
145Keratoconjunctivitis sicca (HP:0001097)1.15992490
146Acanthocytosis (HP:0001927)1.12251011
147Slow-growing hair (HP:0002217)1.10902444
148Abnormality of hair growth rate (HP:0011363)1.10902444
149Hypoplastic toenails (HP:0001800)1.10160843
150Emphysema (HP:0002097)1.07667922
151Melanocytic nevus (HP:0000995)1.04832230
152Keratoconjunctivitis (HP:0001096)1.04561485
153Recurrent skin infections (HP:0001581)1.04501094
154Malnutrition (HP:0004395)1.01811196
155Axonal loss (HP:0003447)1.00635223
156Recurrent bacterial skin infections (HP:0005406)0.96967746
157Seborrheic dermatitis (HP:0001051)0.96253708

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN8.89912117
2PIK3CG4.48637487
3STK243.61030638
4OBSCN3.20671283
5TIE13.02139451
6TRIB32.99839845
7FER2.70661157
8MAPKAPK32.45850693
9MAP2K32.45352769
10PHKG12.40083997
11PHKG22.40083997
12DYRK32.24328610
13ABL22.22707745
14MAP3K32.18893432
15NEK12.17644686
16IRAK22.07346179
17IRAK41.98488233
18FGFR11.93295311
19IRAK11.93183095
20TAOK11.87518647
21ERN11.82799737
22MST1R1.81045053
23WNK11.79005558
24PDK41.72483779
25PDK31.72483779
26PIM21.71043668
27MAPK151.66925244
28MAP3K121.66624752
29STK38L1.56763355
30SGK2231.54685569
31SGK4941.54685569
32IKBKE1.53092764
33AKT31.50501061
34MAP3K91.48964386
35MAP3K111.37676159
36RIPK11.37529053
37DMPK1.36793878
38NME11.32647172
39EPHB11.28133329
40MAP2K41.26760420
41MAP2K61.24641408
42MOS1.24351082
43MAP3K71.23483317
44PKN21.23214757
45MAP3K21.22724962
46PINK11.20209956
47PDK21.20023472
48GRK71.18362091
49TGFBR11.16022860
50PDGFRB1.15613198
51ADRBK11.12929921
52LRRK21.03091151
53TBK10.99167741
54LATS10.96261964
55MAP3K60.93535783
56PTK60.92050613
57RPS6KB20.91190263
58EPHB20.90865870
59MAPK120.89952847
60IRAK30.88464089
61SGK20.84759082
62KSR20.84225445
63TSSK60.84096209
64IKBKB0.83881497
65TGFBR20.82714390
66MAP3K10.79494214
67BCKDK0.78889266
68FGFR40.78189706
69STK30.77089470
70MAP3K50.75215455
71EPHA20.73766778
72PRKD10.73557466
73SGK30.71175721
74MET0.71056199
75PDGFRA0.65768369
76FGFR20.62892654
77MAPK110.60127683
78LATS20.60039590
79MTOR0.59971967
80TRPM70.57184847
81EPHA30.56910873
82ERBB30.56697459
83BCR0.55821747
84FGR0.55492124
85LIMK10.54156202
86DDR20.53438035
87NEK60.49227920
88MAPKAPK20.48412401
89MAP2K10.48144952
90EEF2K0.47886734
91GRK50.46732139
92FGFR30.46682220
93PRKCH0.45581444
94HCK0.43250609
95BMX0.43114353
96PRPF4B0.42667260
97NTRK20.42450396
98MARK20.42116519
99CHUK0.41758235
100PAK60.38591922
101ILK0.38352416
102BRAF0.37594473
103PIK3CA0.37411571
104TAOK30.36516460
105CDK60.36102527
106TYRO30.34811497
107CDK120.34324723
108STK380.34216873
109RET0.33979959
110ABL10.33487458
111MST40.33201711
112TYK20.32943312
113PKN10.32825717
114EIF2AK30.31877146
115DAPK30.31838434
116RPS6KA10.31289168
117CAMK2A0.31188810
118PAK30.30705512
119MAP3K140.30598504
120GRK10.30110359
121SGK10.29264617
122GRK60.28671918
123PDPK10.28313567
124TAOK20.27462180
125DYRK1B0.26801236
126PTK20.26266858
127ROCK20.26164606
128PIM10.25307531
129MAPK70.25108485
130BLK0.24725727
131ICK0.23956429
132CAMK2G0.23847366
133FYN0.22169465
134PAK40.21533235
135RPS6KA40.20999934
136PRKCI0.20576010
137TESK10.20163827
138CAMK10.19897251
139PRKACA0.19789322
140PAK20.19126099
141JAK10.18867763
142SIK10.18079902
143MAPK40.17949203
144GSK3A0.17940206
145ROCK10.17396743
146RPS6KC10.17267007
147RPS6KL10.17267007
148PRKCE0.16653012
149JAK20.16301713
150CSK0.16228455
151STK100.15294018
152PRKAA20.14844227
153PRKACG0.14766336
154RPS6KA60.13645715
155EIF2AK20.12777917
156MAPK80.12496504
157DYRK1A0.11039584

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine metabolism_Homo sapiens_hsa003603.83594024
2Salivary secretion_Homo sapiens_hsa049703.76552775
3Fat digestion and absorption_Homo sapiens_hsa049753.68867835
4NOD-like receptor signaling pathway_Homo sapiens_hsa046213.03366624
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.95835907
6Sphingolipid metabolism_Homo sapiens_hsa006002.93605874
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.54722089
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.41825684
9Histidine metabolism_Homo sapiens_hsa003402.25789964
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.24421302
11Fatty acid elongation_Homo sapiens_hsa000622.09964349
12Tyrosine metabolism_Homo sapiens_hsa003502.09537789
13Ovarian steroidogenesis_Homo sapiens_hsa049132.04450515
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.01573327
15Glycerolipid metabolism_Homo sapiens_hsa005611.99971253
16Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.88874746
17Circadian rhythm_Homo sapiens_hsa047101.83836063
18beta-Alanine metabolism_Homo sapiens_hsa004101.83540429
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.73160387
20p53 signaling pathway_Homo sapiens_hsa041151.67861048
21Glycerophospholipid metabolism_Homo sapiens_hsa005641.58745740
22Phototransduction_Homo sapiens_hsa047441.56509563
23Fatty acid degradation_Homo sapiens_hsa000711.55659710
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.53767214
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.47008924
26GnRH signaling pathway_Homo sapiens_hsa049121.46777784
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.43305934
28Linoleic acid metabolism_Homo sapiens_hsa005911.39613423
29Renin secretion_Homo sapiens_hsa049241.37630561
30Arachidonic acid metabolism_Homo sapiens_hsa005901.33438649
31Chemical carcinogenesis_Homo sapiens_hsa052041.28487602
32Olfactory transduction_Homo sapiens_hsa047401.25143114
33Gastric acid secretion_Homo sapiens_hsa049711.19352535
34Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.18125594
35VEGF signaling pathway_Homo sapiens_hsa043701.17203082
36Dilated cardiomyopathy_Homo sapiens_hsa054141.16883519
37Arginine biosynthesis_Homo sapiens_hsa002201.15110348
38Vascular smooth muscle contraction_Homo sapiens_hsa042701.15042517
39Propanoate metabolism_Homo sapiens_hsa006401.10602515
40Carbon metabolism_Homo sapiens_hsa012001.10332051
41Glucagon signaling pathway_Homo sapiens_hsa049221.09878366
42Collecting duct acid secretion_Homo sapiens_hsa049661.08416621
43Cardiac muscle contraction_Homo sapiens_hsa042601.07319085
44Nitrogen metabolism_Homo sapiens_hsa009101.06729869
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05243802
46Alzheimers disease_Homo sapiens_hsa050101.04172594
47Choline metabolism in cancer_Homo sapiens_hsa052311.02786873
48Oxytocin signaling pathway_Homo sapiens_hsa049211.01143228
49Fatty acid metabolism_Homo sapiens_hsa012121.00196510
50Pertussis_Homo sapiens_hsa051330.98988301
51Glioma_Homo sapiens_hsa052140.98709785
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.96699708
53Long-term potentiation_Homo sapiens_hsa047200.95765032
54Insulin signaling pathway_Homo sapiens_hsa049100.91723867
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89158946
56Endocytosis_Homo sapiens_hsa041440.88561389
57PPAR signaling pathway_Homo sapiens_hsa033200.87950816
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84921365
59Staphylococcus aureus infection_Homo sapiens_hsa051500.84269404
60ErbB signaling pathway_Homo sapiens_hsa040120.83047756
61Tight junction_Homo sapiens_hsa045300.82698040
62Melanogenesis_Homo sapiens_hsa049160.82265543
63MAPK signaling pathway_Homo sapiens_hsa040100.82149744
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82026938
65Insulin resistance_Homo sapiens_hsa049310.81708215
66Inositol phosphate metabolism_Homo sapiens_hsa005620.80076315
67Starch and sucrose metabolism_Homo sapiens_hsa005000.76496013
68ECM-receptor interaction_Homo sapiens_hsa045120.76418523
69Retinol metabolism_Homo sapiens_hsa008300.76041866
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73785070
71Circadian entrainment_Homo sapiens_hsa047130.73221992
72Vibrio cholerae infection_Homo sapiens_hsa051100.72499464
73Long-term depression_Homo sapiens_hsa047300.72317686
74Calcium signaling pathway_Homo sapiens_hsa040200.72257267
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.71476585
76Jak-STAT signaling pathway_Homo sapiens_hsa046300.71157177
77Biosynthesis of amino acids_Homo sapiens_hsa012300.70574567
78Estrogen signaling pathway_Homo sapiens_hsa049150.69648674
79Ether lipid metabolism_Homo sapiens_hsa005650.69340938
80Caffeine metabolism_Homo sapiens_hsa002320.69197358
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.68936276
82Pancreatic secretion_Homo sapiens_hsa049720.68133461
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.66295382
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64491307
85FoxO signaling pathway_Homo sapiens_hsa040680.64043051
86Fatty acid biosynthesis_Homo sapiens_hsa000610.61780867
87Acute myeloid leukemia_Homo sapiens_hsa052210.61607982
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61262612
89Proteoglycans in cancer_Homo sapiens_hsa052050.60311709
90Glutamatergic synapse_Homo sapiens_hsa047240.59925028
91Focal adhesion_Homo sapiens_hsa045100.59651082
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59392316
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.59085421
94Pyruvate metabolism_Homo sapiens_hsa006200.58107357
95Bladder cancer_Homo sapiens_hsa052190.57892195
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57837196
97Platelet activation_Homo sapiens_hsa046110.55436728
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54851787
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.53638961
100Adherens junction_Homo sapiens_hsa045200.53351154
101Hepatitis C_Homo sapiens_hsa051600.53236167
102NF-kappa B signaling pathway_Homo sapiens_hsa040640.50359667
103Mineral absorption_Homo sapiens_hsa049780.50192251
104Butanoate metabolism_Homo sapiens_hsa006500.49650788
105Amoebiasis_Homo sapiens_hsa051460.49619601
106Synaptic vesicle cycle_Homo sapiens_hsa047210.49564759
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49365914
108Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47538889
109Steroid biosynthesis_Homo sapiens_hsa001000.46170947
110Parkinsons disease_Homo sapiens_hsa050120.46043432
111Serotonergic synapse_Homo sapiens_hsa047260.45801598
112Toxoplasmosis_Homo sapiens_hsa051450.45496178
113Leukocyte transendothelial migration_Homo sapiens_hsa046700.44639348
114Amphetamine addiction_Homo sapiens_hsa050310.43953796
115Salmonella infection_Homo sapiens_hsa051320.43598109
116Influenza A_Homo sapiens_hsa051640.43552673
117Renin-angiotensin system_Homo sapiens_hsa046140.43086924
118Rap1 signaling pathway_Homo sapiens_hsa040150.42160199
119Arginine and proline metabolism_Homo sapiens_hsa003300.41544982
120Axon guidance_Homo sapiens_hsa043600.40854508
121Shigellosis_Homo sapiens_hsa051310.40739131
122Steroid hormone biosynthesis_Homo sapiens_hsa001400.39600896
123Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39418589
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.39403567
125MicroRNAs in cancer_Homo sapiens_hsa052060.38868025
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37849025
127Ras signaling pathway_Homo sapiens_hsa040140.37321259
128Oxidative phosphorylation_Homo sapiens_hsa001900.37300795
129Bile secretion_Homo sapiens_hsa049760.37053213
130Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36046619
131Dorso-ventral axis formation_Homo sapiens_hsa043200.35164348
132Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35025496
133AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34477139
134AMPK signaling pathway_Homo sapiens_hsa041520.33624664
135Tuberculosis_Homo sapiens_hsa051520.33573312
136Hippo signaling pathway_Homo sapiens_hsa043900.33038130
137Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31737907
138Tryptophan metabolism_Homo sapiens_hsa003800.31442135
139Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.30956746
140Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30741805
141Dopaminergic synapse_Homo sapiens_hsa047280.30367210
142ABC transporters_Homo sapiens_hsa020100.29930974
143Renal cell carcinoma_Homo sapiens_hsa052110.29248849
144Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29187227
145TNF signaling pathway_Homo sapiens_hsa046680.28572304
146HIF-1 signaling pathway_Homo sapiens_hsa040660.28473313
147Rheumatoid arthritis_Homo sapiens_hsa053230.25188382
148Prion diseases_Homo sapiens_hsa050200.24410736
149Apoptosis_Homo sapiens_hsa042100.23887174
150Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.23362098
151Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.23103307
152Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.20805574
153TGF-beta signaling pathway_Homo sapiens_hsa043500.18349932
154Legionellosis_Homo sapiens_hsa051340.16927247
155Basal transcription factors_Homo sapiens_hsa030220.16350254

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