ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	keratinocyte differentiation (GO:0030216)	9.95231805
2	water homeostasis (GO:0030104)	9.12939046
3	peptide cross-linking (GO:0018149)	7.79138642
4	epidermal cell differentiation (GO:0009913)	7.70659490
5	hair cycle (GO:0042633)	7.42249213
6	molting cycle (GO:0042303)	7.42249213
7	long-chain fatty acid biosynthetic process (GO:0042759)	6.99173344
8	keratinocyte development (GO:0003334)	6.62585928
9	epidermis development (GO:0008544)	6.57668815
10	linoleic acid metabolic process (GO:0043651)	6.57540101
11	intermediate filament organization (GO:0045109)	6.49056242
12	bundle of His cell to Purkinje myocyte communication (GO:0086069)	6.35876888
13	phosphatidylserine acyl-chain remodeling (GO:0036150)	6.32457227
14	phosphatidylinositol acyl-chain remodeling (GO:0036149)	6.11905633
15	fatty acid elongation (GO:0030497)	5.70964515
16	lipoxygenase pathway (GO:0019372)	5.50462863
17	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	4.92407864
18	lateral sprouting from an epithelium (GO:0060601)	4.91719906
19	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	4.77125798
20	hemidesmosome assembly (GO:0031581)	4.46971852
21	phosphatidylcholine acyl-chain remodeling (GO:0036151)	4.41716066
22	epithelial cell differentiation involved in prostate gland development (GO:0060742)	4.35055565
23	polarized epithelial cell differentiation (GO:0030859)	4.21584889
24	establishment of planar polarity (GO:0001736)	4.16163403
25	establishment of tissue polarity (GO:0007164)	4.16163403
26	skin morphogenesis (GO:0043589)	3.99165067
27	gap junction assembly (GO:0016264)	3.83587359
28	intermediate filament cytoskeleton organization (GO:0045104)	3.78815260
29	arachidonic acid secretion (GO:0050482)	3.78709605
30	icosanoid secretion (GO:0032309)	3.78709605
31	regulation of cholesterol homeostasis (GO:2000188)	3.76018869
32	regulation of keratinocyte differentiation (GO:0045616)	3.69005998
33	phosphatidylserine metabolic process (GO:0006658)	3.68227021
34	hair follicle morphogenesis (GO:0031069)	3.66149219
35	intermediate filament-based process (GO:0045103)	3.65685402
36	detection of bacterium (GO:0016045)	3.59470318
37	one-carbon compound transport (GO:0019755)	3.57058225
38	intestinal epithelial cell development (GO:0060576)	3.45401565
39	regulation of glomerular filtration (GO:0003093)	3.36356017
40	endothelium development (GO:0003158)	3.20661271
41	epithelium development (GO:0060429)	3.16808374
42	detection of other organism (GO:0098543)	3.16781748
43	regulation of phospholipase A2 activity (GO:0032429)	3.15438191
44	negative regulation of heart growth (GO:0061117)	3.12702119
45	negative regulation of cardiac muscle tissue growth (GO:0055022)	3.12702119
46	fatty acid derivative transport (GO:1901571)	3.11038849
47	icosanoid transport (GO:0071715)	3.11038849
48	molting cycle process (GO:0022404)	3.10873163
49	hair cycle process (GO:0022405)	3.10873163
50	ceramide biosynthetic process (GO:0046513)	3.05108798
51	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	3.03289440
52	establishment of skin barrier (GO:0061436)	20.5223437
53	phosphatidylglycerol metabolic process (GO:0046471)	2.96881157
54	retinol metabolic process (GO:0042572)	2.92425138
55	fibrinolysis (GO:0042730)	2.91705005
56	atrial cardiac muscle cell action potential (GO:0086014)	2.90470597
57	very long-chain fatty acid metabolic process (GO:0000038)	2.90230430
58	cellular response to antibiotic (GO:0071236)	2.87738562
59	polyol transport (GO:0015791)	2.87161212
60	purine ribonucleotide transport (GO:0015868)	2.86859326
61	regulation of tight junction assembly (GO:2000810)	2.86806076
62	alditol phosphate metabolic process (GO:0052646)	2.86294927
63	adenine nucleotide transport (GO:0051503)	2.81628343
64	phospholipid catabolic process (GO:0009395)	2.78426219
65	negative regulation of stress fiber assembly (GO:0051497)	2.77735617
66	positive regulation of chemokine secretion (GO:0090197)	2.73888473
67	hair follicle development (GO:0001942)	2.71749254
68	regulation of transforming growth factor beta1 production (GO:0032908)	2.71278847
69	negative regulation of interferon-gamma production (GO:0032689)	2.70313350
70	skeletal muscle tissue regeneration (GO:0043403)	2.70172114
71	renal system process involved in regulation of blood volume (GO:0001977)	2.68418654
72	prostaglandin biosynthetic process (GO:0001516)	2.66435917
73	prostanoid biosynthetic process (GO:0046457)	2.66435917
74	regulation of epidermis development (GO:0045682)	2.66224425
75	epithelial cell maturation (GO:0002070)	2.65790339
76	regulation of natural killer cell differentiation (GO:0032823)	2.64591381
77	epithelial cell proliferation (GO:0050673)	2.62881745
78	regulation of epidermal cell differentiation (GO:0045604)	2.62705815
79	eyelid development in camera-type eye (GO:0061029)	2.60907942
80	regulation of chemokine secretion (GO:0090196)	2.59868788
81	positive regulation of epidermal cell differentiation (GO:0045606)	2.59282563
82	regulation of keratinocyte proliferation (GO:0010837)	2.57121506
83	long-chain fatty-acyl-CoA metabolic process (GO:0035336)	2.56732000
84	unsaturated fatty acid biosynthetic process (GO:0006636)	2.55822804
85	trophectodermal cell differentiation (GO:0001829)	2.52363210
86	cellular component disassembly involved in execution phase of apoptosis (GO:0006921)	2.51456843
87	long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)	2.49434402
88	negative regulation of epidermal cell differentiation (GO:0045605)	2.47732308
89	regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)	2.45574324
90	positive regulation of keratinocyte differentiation (GO:0045618)	2.44938686
91	cardiac right ventricle morphogenesis (GO:0003215)	2.44703360
92	morphogenesis of embryonic epithelium (GO:0016331)	2.40005022
93	imidazole-containing compound metabolic process (GO:0052803)	2.38774398
94	mitotic G1 DNA damage checkpoint (GO:0031571)	2.37494239
95	negative regulation of keratinocyte proliferation (GO:0010839)	2.32616432
96	* keratinization (GO:0031424)	18.6019382
97	regulation of water loss via skin (GO:0033561)	17.3296626
98	desmosome organization (GO:0002934)	16.0199349
99	keratinocyte proliferation (GO:0043616)	11.1213512
100	multicellular organismal water homeostasis (GO:0050891)	11.0169351

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	6.12442467
2	P63_26484246_Chip-Seq_KERATINOCYTES_Human	4.32510960
3	SOX9_24532713_ChIP-Seq_HFSC_Mouse	2.77991556
4	ZNF263_19887448_ChIP-Seq_K562_Human	2.59522692
5	RXR_22108803_ChIP-Seq_LS180_Human	2.42517733
6	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	2.29204423
7	* TP63_23658742_ChIP-Seq_EP156T_Human	2.06660056
8	TP63_17297297_ChIP-ChIP_HaCaT_Human	14.8585393
9	* TP63_22573176_ChIP-Seq_HFKS_Human	1.90026705
10	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.81068181
11	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.78317437
12	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.63440921
13	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.61804360
14	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.60718554
15	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.60718554
16	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.58831469
17	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.53431071
18	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.51988178
19	EGR1_19032775_ChIP-ChIP_M12_Human	1.50534156
20	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.35923115
21	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.34504972
22	ERG_20517297_ChIP-Seq_VCAP_Human	1.28492085
23	KLF5_25053715_ChIP-Seq_YYC3_Human	1.26526497
24	* GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.23417388
25	TAF2_19829295_ChIP-Seq_ESCs_Human	1.22491550
26	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.20942424
27	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.20079565
28	SCL_19346495_ChIP-Seq_HPC-7_Human	1.17838731
29	AHR_22903824_ChIP-Seq_MCF-7_Human	1.17680289
30	CTCF_27219007_Chip-Seq_Bcells_Human	1.16535048
31	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.16361644
32	P53_21459846_ChIP-Seq_SAOS-2_Human	1.11257329
33	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.06691996
34	* GATA6_21074721_ChIP-Seq_CACO-2_Human	1.04124294
35	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.01951105
36	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.01621087
37	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.00947432
38	BCOR_27268052_Chip-Seq_Bcells_Human	1.00543579
39	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.99339208
40	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.99339208
41	GATA4_25053715_ChIP-Seq_YYC3_Human	0.98569609
42	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.97666558
43	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.92886747
44	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.92692173
45	CJUN_26792858_Chip-Seq_BT549_Human	0.90978944
46	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.90577868
47	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.90356227
48	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	0.90228496
49	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.90198569
50	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.87993745
51	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.87114983
52	RUNX_20019798_ChIP-Seq_JUKART_Human	0.87067579
53	TCF4_22108803_ChIP-Seq_LS180_Human	0.86285612
54	P68_20966046_ChIP-Seq_HELA_Human	0.86159809
55	AR_21572438_ChIP-Seq_LNCaP_Human	0.85994553
56	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.85079254
57	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.85054532
58	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.85020014
59	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.84249559
60	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.83914789
61	CDX2_22108803_ChIP-Seq_LS180_Human	0.83566799
62	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.80961809
63	ATF3_27146783_Chip-Seq_COLON_Human	0.80310943
64	BCL6_27268052_Chip-Seq_Bcells_Human	0.79426426
65	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.78809635
66	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.78470922
67	RACK7_27058665_Chip-Seq_MCF-7_Human	0.77758170
68	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.77747913
69	CEBPB_22108803_ChIP-Seq_LS180_Human	0.77422738
70	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	0.77410853
71	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.77025103
72	E2F1_20622854_ChIP-Seq_HELA_Human	0.76336049
73	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.76066277
74	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.75481991
75	SMC4_20622854_ChIP-Seq_HELA_Human	0.75387467
76	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.74576973
77	CTCF_20526341_ChIP-Seq_ESCs_Human	0.74554382
78	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.74157633
79	PPARA_22158963_ChIP-Seq_LIVER_Mouse	0.73820159
80	SOX2_20726797_ChIP-Seq_SW620_Human	0.73316378
81	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.72532780
82	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.71494408
83	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.70823597
84	GATA6_25053715_ChIP-Seq_YYC3_Human	0.70709673
85	TBX20_22328084_ChIP-Seq_HEART_Mouse	0.69178799
86	TBX20_22080862_ChIP-Seq_HEART_Mouse	0.69178799
87	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.68991987
88	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.68535313
89	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.67799368
90	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.67743741
91	TP53_18474530_ChIP-ChIP_U2OS_Human	0.66782067
92	LXR_22292898_ChIP-Seq_THP-1_Human	0.66289286
93	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.66111785
94	VDR_22108803_ChIP-Seq_LS180_Human	0.64799933
95	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.64654528
96	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.64512658
97	TP53_16413492_ChIP-PET_HCT116_Human	0.63981635
98	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	0.63873419
99	NANOG_20526341_ChIP-Seq_ESCs_Human	0.63202147
100	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.63081225

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	8.86453181
2	MP0002796_impaired_skin_barrier	8.44011524
3	MP0005275_abnormal_skin_tensile	7.30190991
4	MP0005501_abnormal_skin_physiology	4.71326249
5	MP0010234_abnormal_vibrissa_follicle	4.49963490
6	MP0001188_hyperpigmentation	3.38553530
7	MP0000566_synostosis	3.21349036
8	MP0001216_abnormal_epidermal_layer	3.01324937
9	MP0004947_skin_inflammation	2.85118987
10	MP0000579_abnormal_nail_morphology	2.81048472
11	MP0003453_abnormal_keratinocyte_physiol	2.64547229
12	MP0010771_integument_phenotype	2.64498862
13	MP0004381_abnormal_hair_follicle	2.63403640
14	MP0002095_abnormal_skin_pigmentation	2.46919794
15	MP0000015_abnormal_ear_pigmentation	2.45964303
16	MP0005174_abnormal_tail_pigmentation	2.45666516
17	MP0000383_abnormal_hair_follicle	2.42259567
18	MP0002060_abnormal_skin_morphology	2.37128738
19	MP0010678_abnormal_skin_adnexa	2.33144495
20	MP0002098_abnormal_vibrissa_morphology	2.06750338
21	MP0000647_abnormal_sebaceous_gland	1.98234554
22	MP0000377_abnormal_hair_follicle	1.86862994
23	MP0003011_delayed_dark_adaptation	1.78748642
24	MP0001984_abnormal_olfaction	1.74390106
25	MP0003941_abnormal_skin_development	1.71004308
26	MP0003705_abnormal_hypodermis_morpholog	1.67400906
27	MP0009931_abnormal_skin_appearance	1.61588103
28	MP0004782_abnormal_surfactant_physiolog	1.59954743
29	MP0000427_abnormal_hair_cycle	1.50874686
30	MP0003191_abnormal_cellular_cholesterol	1.42142903
31	MP0000367_abnormal_coat/_hair	1.31716817
32	MP0002009_preneoplasia	1.29499489
33	MP0001191_abnormal_skin_condition	1.21412025
34	MP0000467_abnormal_esophagus_morphology	1.13753676
35	MP0005409_darkened_coat_color	1.03253372
36	MP0005075_abnormal_melanosome_morpholog	1.02049404
37	MP0002177_abnormal_outer_ear	1.01945055
38	MP0002166_altered_tumor_susceptibility	0.96981451
39	MP0005257_abnormal_intraocular_pressure	0.94140175
40	MP0000465_gastrointestinal_hemorrhage	0.93463549
41	MP0009384_cardiac_valve_regurgitation	0.92083046
42	MP0001851_eye_inflammation	0.88338593
43	MP0009780_abnormal_chondrocyte_physiolo	0.83791520
44	MP0001243_abnormal_dermal_layer	0.83475883
45	MP0002006_tumorigenesis	0.79608714
46	MP0003763_abnormal_thymus_physiology	0.76145747
47	MP0003279_aneurysm	0.72925466
48	MP0001784_abnormal_fluid_regulation	0.69498174
49	MP0009333_abnormal_splenocyte_physiolog	0.69474957
50	MP0003638_abnormal_response/metabolism_	0.67533598
51	MP0003566_abnormal_cell_adhesion	0.67036660
52	MP0002653_abnormal_ependyma_morphology	0.61614277
53	MP0005647_abnormal_sex_gland	0.58685100
54	MP0005023_abnormal_wound_healing	0.57850249
55	MP0001348_abnormal_lacrimal_gland	0.52274203
56	MP0001853_heart_inflammation	0.52075608
57	MP0010030_abnormal_orbit_morphology	0.51760445
58	MP0000762_abnormal_tongue_morphology	0.50914807
59	MP0009053_abnormal_anal_canal	0.50869729
60	MP0008789_abnormal_olfactory_epithelium	0.50519811
61	MP0000685_abnormal_immune_system	0.47709920
62	MP0000372_irregular_coat_pigmentation	0.46094276
63	MP0005671_abnormal_response_to	0.46079772
64	MP0001299_abnormal_eye_distance/	0.44570274
65	MP0001340_abnormal_eyelid_morphology	0.44139681
66	MP0000428_abnormal_craniofacial_morphol	0.42270491
67	MP0000462_abnormal_digestive_system	0.41620995
68	MP0001440_abnormal_grooming_behavior	0.38701710
69	MP0002877_abnormal_melanocyte_morpholog	0.37700450
70	MP0004185_abnormal_adipocyte_glucose	0.33988218
71	MP0005499_abnormal_olfactory_system	0.33459664
72	MP0005394_taste/olfaction_phenotype	0.33459664
73	MP0002234_abnormal_pharynx_morphology	0.33213243
74	MP0008438_abnormal_cutaneous_collagen	0.32909156
75	MP0001542_abnormal_bone_strength	0.32046471
76	MP0001346_abnormal_lacrimal_gland	0.31714196
77	MP0002909_abnormal_adrenal_gland	0.29143901
78	MP0004484_altered_response_of	0.28428946
79	MP0000627_abnormal_mammary_gland	0.28254350
80	MP0002111_abnormal_tail_morphology	0.27496239
81	MP0005197_abnormal_uvea_morphology	0.25118347
82	MP0002233_abnormal_nose_morphology	0.24860326
83	MP0001186_pigmentation_phenotype	0.24045796
84	MP0005171_absent_coat_pigmentation	0.20658063
85	MP0005595_abnormal_vascular_smooth	0.20639008
86	MP0004215_abnormal_myocardial_fiber	0.19535299
87	MP0005503_abnormal_tendon_morphology	0.18590795
88	MP0005076_abnormal_cell_differentiation	0.18322449
89	MP0002998_abnormal_bone_remodeling	0.18322248
90	MP0002277_abnormal_respiratory_mucosa	0.17387094
91	MP0000858_altered_metastatic_potential	0.17363519
92	MP0002148_abnormal_hypersensitivity_rea	0.17338482
93	MP0004883_abnormal_blood_vessel	0.17193582
94	MP0005508_abnormal_skeleton_morphology	0.16641987
95	MP0005025_abnormal_response_to	0.16600260
96	MP0003448_altered_tumor_morphology	0.15097452
97	MP0006138_congestive_heart_failure	0.15062767
98	MP0001756_abnormal_urination	0.13812766
99	MP0005387_immune_system_phenotype	0.13760018
100	MP0001790_abnormal_immune_system	0.13760018

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased IgE level (HP:0003212)	9.91716125
2	Erythroderma (HP:0001019)	8.69965255
3	Conjunctival hamartoma (HP:0100780)	7.92872460
4	Congenital ichthyosiform erythroderma (HP:0007431)	7.59637465
5	Palmoplantar hyperkeratosis (HP:0000972)	7.52324685
6	Hypotrichosis (HP:0001006)	7.47910146
7	Erythema (HP:0010783)	7.38332928
8	Palmar hyperkeratosis (HP:0010765)	7.18096197
9	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	6.39974134
10	Plantar hyperkeratosis (HP:0007556)	6.33034935
11	Abnormality of the axillary hair (HP:0100134)	5.70464760
12	Abnormality of secondary sexual hair (HP:0009888)	5.70464760
13	Fragile nails (HP:0001808)	5.13391133
14	Hamartoma of the eye (HP:0010568)	5.07042686
15	Woolly hair (HP:0002224)	5.05211163
16	Thick nail (HP:0001805)	4.61751938
17	Eczematoid dermatitis (HP:0000976)	4.37410035
18	Alopecia of scalp (HP:0002293)	4.35752262
19	Palmoplantar keratoderma (HP:0000982)	4.26343445
20	Aplasia involving bones of the upper limbs (HP:0009823)	4.21735983
21	Aplasia of the phalanges of the hand (HP:0009802)	4.21735983
22	Aplasia involving bones of the extremities (HP:0009825)	4.21735983
23	Parakeratosis (HP:0001036)	4.21095829
24	Corneal erosion (HP:0200020)	4.16926269
25	Onycholysis (HP:0001806)	4.13598958
26	Abnormality of nail color (HP:0100643)	4.11796742
27	Abnormal blistering of the skin (HP:0008066)	4.02595303
28	Right ventricular cardiomyopathy (HP:0011663)	3.82298016
29	Gangrene (HP:0100758)	3.58917571
30	Abnormality of the salivary glands (HP:0010286)	3.47425827
31	Lip pit (HP:0100267)	3.38996389
32	Selective tooth agenesis (HP:0001592)	3.34005087
33	Abnormality of permanent molar morphology (HP:0011071)	3.11638826
34	Abnormality of the dental root (HP:0006486)	3.11638826
35	Taurodontia (HP:0000679)	3.11638826
36	Nasolacrimal duct obstruction (HP:0000579)	2.99531875
37	Sparse scalp hair (HP:0002209)	2.99472108
38	Sparse eyelashes (HP:0000653)	2.93978862
39	Abnormality of molar (HP:0011077)	2.90789748
40	Abnormality of molar morphology (HP:0011070)	2.90789748
41	Pili torti (HP:0003777)	2.90477478
42	Melanocytic nevus (HP:0000995)	2.88449785
43	Abnormal hair laboratory examination (HP:0003328)	2.87482878
44	Hypergammaglobulinemia (HP:0010702)	2.84701867
45	Hamartoma (HP:0010566)	2.84174134
46	Dry hair (HP:0011359)	2.83873193
47	Hypohidrosis (HP:0000966)	2.83842065
48	Split foot (HP:0001839)	2.77365562
49	Abnormality of the dental pulp (HP:0006479)	2.74845000
50	Xerostomia (HP:0000217)	2.66052390
51	Conical tooth (HP:0000698)	2.59745754
52	Pruritus (HP:0000989)	2.57596601
53	Absent eyelashes (HP:0000561)	2.56166155
54	Nail dystrophy (HP:0008404)	2.54244060
55	Ectropion (HP:0000656)	2.44940307
56	Hypoplastic labia majora (HP:0000059)	2.43824866
57	Abnormality of the lacrimal duct (HP:0011481)	2.39818694
58	Neonatal death (HP:0003811)	2.36898431
59	Duplicated collecting system (HP:0000081)	2.34454093
60	Abnormality of the labia majora (HP:0012881)	2.22190248
61	Short middle phalanx of the 5th finger (HP:0004220)	2.21289665
62	Slow-growing hair (HP:0002217)	2.16294373
63	Abnormality of hair growth rate (HP:0011363)	2.16294373
64	Long nose (HP:0003189)	2.12658646
65	Abnormality of the nasolacrimal system (HP:0000614)	2.10945991
66	Natal tooth (HP:0000695)	2.07298495
67	Abnormality of the renal collecting system (HP:0004742)	2.07187165
68	Hyperhidrosis (HP:0000975)	2.06303769
69	Oligodontia (HP:0000677)	1.99277649
70	Blepharitis (HP:0000498)	1.97178850
71	Acanthosis nigricans (HP:0000956)	1.95223132
72	Milia (HP:0001056)	1.90115986
73	Septate vagina (HP:0001153)	1.90004375
74	Skin ulcer (HP:0200042)	1.82322285
75	Curly hair (HP:0002212)	1.82277606
76	Mixed hearing impairment (HP:0000410)	1.79671090
77	Advanced eruption of teeth (HP:0006288)	1.76212277
78	Hypoplasia of dental enamel (HP:0006297)	1.76169624
79	Abnormality of incisor morphology (HP:0011063)	1.75076084
80	Absent hair (HP:0002298)	1.72843592
81	Depressed nasal tip (HP:0000437)	1.72107217
82	Ventricular tachycardia (HP:0004756)	1.69823537
83	Lack of skin elasticity (HP:0100679)	1.64478957
84	Verrucae (HP:0200043)	1.63686695
85	Papilloma (HP:0012740)	1.63686695
86	Breast hypoplasia (HP:0003187)	1.57037757
87	Dry skin (HP:0000958)	1.56921070
88	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	1.55810940
89	Coronal craniosynostosis (HP:0004440)	1.54293470
90	Partial duplication of thumb phalanx (HP:0009944)	1.50717284
91	Non-midline cleft lip (HP:0100335)	1.50477965
92	Ridged nail (HP:0001807)	1.49053300
93	Abnormality of sodium homeostasis (HP:0010931)	1.48714200
94	Tetraparesis (HP:0002273)	1.47610655
95	Abnormality of the columella (HP:0009929)	1.45450766
96	Thickened helices (HP:0000391)	1.44989172
97	Ventricular fibrillation (HP:0001663)	1.44436621
98	Alacrima (HP:0000522)	1.43860747
99	Segmental peripheral demyelination/remyelination (HP:0003481)	1.43135862
100	Partial duplication of the phalanx of hand (HP:0009999)	1.42554364

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EEF2K	6.56316249
2	STK24	5.86160405
3	MAPKAPK3	5.28474650
4	TGFBR1	3.60680419
5	MAP3K6	3.46641292
6	FGFR1	3.00792060
7	MAPK12	2.97336685
8	TRPM7	2.90683117
9	TESK2	2.76516576
10	TESK1	2.74042233
11	MAPKAPK5	2.51386483
12	GRK7	2.36645943
13	MAPK7	2.23976894
14	RPS6KB2	2.23479098
15	TAOK3	2.08124362
16	KIT	1.77447467
17	KDR	1.74608622
18	PIK3CG	1.69667008
19	FGFR3	1.54983395
20	FER	1.47828903
21	MAP3K2	1.45451188
22	MAP3K3	1.34574338
23	SGK223	1.26882035
24	SGK494	1.26882035
25	MAPK13	1.19194783
26	FGFR2	1.15018829
27	STK3	1.15018449
28	MAP3K7	1.12781153
29	MST1R	1.05587906
30	RIPK1	1.05427111
31	LIMK1	1.00606943
32	FRK	1.00237663
33	MAPK11	0.97423006
34	MAP2K6	0.93995017
35	IKBKB	0.90477649
36	CDK8	0.89547667
37	TBK1	0.80369222
38	MAPKAPK2	0.80129769
39	ADRBK2	0.77691133
40	RPS6KB1	0.77299785
41	MOS	0.76443711
42	PRKCE	0.75293643
43	MINK1	0.74677361
44	TGFBR2	0.65904686
45	PBK	0.64815703
46	LATS1	0.64020901
47	PRKAA2	0.57985640
48	LRRK2	0.55508032
49	ADRBK1	0.52772314
50	PRPF4B	0.52001257
51	TAF1	0.50451798
52	ILK	0.49653004
53	BRSK2	0.49400670
54	MYLK	0.47686027
55	MAP2K4	0.45353085
56	PRKCG	0.44625320
57	GSK3A	0.41788981
58	MAP4K1	0.41707738
59	IKBKE	0.41260822
60	ABL2	0.41140132
61	EPHA2	0.39351906
62	SGK1	0.39110322
63	NLK	0.38003343
64	GRK6	0.35464935
65	MAP3K1	0.34275300
66	SMG1	0.34173236
67	SGK2	0.32740621
68	RPS6KA2	0.31649159
69	MARK2	0.31091803
70	IGF1R	0.30524960
71	GRK5	0.29933946
72	STK10	0.29172162
73	NME1	0.28681556
74	MAP3K9	0.27608299
75	BCR	0.27526810
76	ITK	0.23528232
77	CDK3	0.23393546
78	RPS6KA4	0.23040378
79	IRAK4	0.21242783
80	MTOR	0.20660755
81	FES	0.20255905
82	PRKD1	0.19924622
83	STK11	0.19645952
84	MAPK9	0.19541688
85	PRKCD	0.18545797
86	CSF1R	0.18260174
87	VRK1	0.16639627
88	SIK1	0.16550820
89	VRK2	0.15113110
90	PRKD2	0.15039125
91	EPHA4	0.14170678
92	PIM2	0.13534070
93	ERN1	0.12733561
94	STK38L	0.12281426
95	AKT3	0.11358064
96	DMPK	0.11047523
97	TYK2	0.08554617
98	ABL1	0.08155662
99	SGK3	0.07799941
100	CDK7	0.07643340

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	6.66037846
2	Linoleic acid metabolism_Homo sapiens_hsa00591	5.16500093
3	Ether lipid metabolism_Homo sapiens_hsa00565	3.91836451
4	Arachidonic acid metabolism_Homo sapiens_hsa00590	3.03556860
5	Histidine metabolism_Homo sapiens_hsa00340	3.00036221
6	Fatty acid elongation_Homo sapiens_hsa00062	2.47444193
7	Staphylococcus aureus infection_Homo sapiens_hsa05150	2.47375516
8	Sphingolipid metabolism_Homo sapiens_hsa00600	2.21939939
9	Phototransduction_Homo sapiens_hsa04744	2.14664203
10	Circadian rhythm_Homo sapiens_hsa04710	2.07699891
11	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.75980798
12	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.71476331
13	GnRH signaling pathway_Homo sapiens_hsa04912	1.68778409
14	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.55975148
15	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.51372642
16	Renin secretion_Homo sapiens_hsa04924	1.42946551
17	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.38101827
18	Long-term depression_Homo sapiens_hsa04730	1.34998608
19	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.33543687
20	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.28999670
21	Retinol metabolism_Homo sapiens_hsa00830	1.26885161
22	VEGF signaling pathway_Homo sapiens_hsa04370	1.26830702
23	Ras signaling pathway_Homo sapiens_hsa04014	1.16696636
24	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.15885223
25	Nitrogen metabolism_Homo sapiens_hsa00910	1.13865826
26	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.10141574
27	Serotonergic synapse_Homo sapiens_hsa04726	1.09906335
28	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.06411650
29	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.05628874
30	Salivary secretion_Homo sapiens_hsa04970	1.05359704
31	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.96911275
32	Platelet activation_Homo sapiens_hsa04611	0.94697772
33	Primary immunodeficiency_Homo sapiens_hsa05340	0.89687249
34	Phenylalanine metabolism_Homo sapiens_hsa00360	0.88992732
35	Pertussis_Homo sapiens_hsa05133	0.87898074
36	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.85434639
37	Amoebiasis_Homo sapiens_hsa05146	0.82316692
38	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.82061053
39	Fat digestion and absorption_Homo sapiens_hsa04975	0.80503173
40	ECM-receptor interaction_Homo sapiens_hsa04512	0.74997694
41	Gastric acid secretion_Homo sapiens_hsa04971	0.74729788
42	Pancreatic secretion_Homo sapiens_hsa04972	0.71755148
43	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.70034794
44	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.67032966
45	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.65905797
46	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.65887652
47	Choline metabolism in cancer_Homo sapiens_hsa05231	0.65842473
48	beta-Alanine metabolism_Homo sapiens_hsa00410	0.64603674
49	Glutamatergic synapse_Homo sapiens_hsa04724	0.63852782
50	Protein export_Homo sapiens_hsa03060	0.60833363
51	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.59384628
52	Melanogenesis_Homo sapiens_hsa04916	0.58484764
53	Long-term potentiation_Homo sapiens_hsa04720	0.58127091
54	Endocytosis_Homo sapiens_hsa04144	0.57483814
55	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.56603539
56	Toxoplasmosis_Homo sapiens_hsa05145	0.54234082
57	Asthma_Homo sapiens_hsa05310	0.54086480
58	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.53095495
59	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.52588738
60	MicroRNAs in cancer_Homo sapiens_hsa05206	0.51200626
61	Tuberculosis_Homo sapiens_hsa05152	0.50535685
62	Allograft rejection_Homo sapiens_hsa05330	0.50306629
63	Graft-versus-host disease_Homo sapiens_hsa05332	0.49531115
64	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.49284243
65	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.49202486
66	Antigen processing and presentation_Homo sapiens_hsa04612	0.46668563
67	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.46123714
68	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.45112930
69	Calcium signaling pathway_Homo sapiens_hsa04020	0.43954261
70	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.43174088
71	Fatty acid degradation_Homo sapiens_hsa00071	0.42542647
72	Circadian entrainment_Homo sapiens_hsa04713	0.42350416
73	Tyrosine metabolism_Homo sapiens_hsa00350	0.40949047
74	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.40929146
75	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.39663975
76	Rap1 signaling pathway_Homo sapiens_hsa04015	0.38733314
77	Bladder cancer_Homo sapiens_hsa05219	0.38608453
78	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.38307746
79	Fatty acid metabolism_Homo sapiens_hsa01212	0.37389162
80	Alzheimers disease_Homo sapiens_hsa05010	0.37369818
81	Notch signaling pathway_Homo sapiens_hsa04330	0.36506963
82	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.36305712
83	ABC transporters_Homo sapiens_hsa02010	0.35615439
84	PPAR signaling pathway_Homo sapiens_hsa03320	0.34968340
85	Proteasome_Homo sapiens_hsa03050	0.34116959
86	Olfactory transduction_Homo sapiens_hsa04740	0.31981056
87	Salmonella infection_Homo sapiens_hsa05132	0.31508003
88	p53 signaling pathway_Homo sapiens_hsa04115	0.29669805
89	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.29465384
90	Shigellosis_Homo sapiens_hsa05131	0.28346735
91	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.27872036
92	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.26095172
93	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.25621247
94	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.24269372
95	Tight junction_Homo sapiens_hsa04530	0.21909600
96	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.21609914
97	Basal cell carcinoma_Homo sapiens_hsa05217	0.21265428
98	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.20931284
99	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.19310998
100	Chemical carcinogenesis_Homo sapiens_hsa05204	0.19190466

LCE5A

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »