LCK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)8.78277664
2negative thymic T cell selection (GO:0045060)8.02913992
3positive T cell selection (GO:0043368)7.75701215
4positive thymic T cell selection (GO:0045059)7.59544251
5negative regulation of cell killing (GO:0031342)7.40594796
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.40594796
7thymic T cell selection (GO:0045061)6.82835027
8T cell selection (GO:0045058)6.76375478
9regulation of isotype switching to IgG isotypes (GO:0048302)6.70724018
10interferon-gamma production (GO:0032609)6.24967607
11* positive regulation of gamma-delta T cell activation (GO:0046645)6.10049638
12cellular response to interleukin-15 (GO:0071350)6.09335743
13response to interleukin-15 (GO:0070672)6.08960587
14positive regulation of interleukin-2 biosynthetic process (GO:0045086)6.06159290
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.91653846
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.91653846
17* T cell receptor signaling pathway (GO:0050852)5.81248314
18* positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.59841472
19* regulation of gamma-delta T cell differentiation (GO:0045586)5.57667300
20cytidine metabolic process (GO:0046087)5.53574520
21cytidine catabolic process (GO:0006216)5.53574520
22cytidine deamination (GO:0009972)5.53574520
23T cell migration (GO:0072678)5.49223376
24leukocyte aggregation (GO:0070486)5.48010613
25regulation of T cell tolerance induction (GO:0002664)5.35189254
26pyrimidine ribonucleoside catabolic process (GO:0046133)5.16857941
27* T cell costimulation (GO:0031295)5.16798224
28* lymphocyte costimulation (GO:0031294)5.10184580
29activated T cell proliferation (GO:0050798)5.04654705
30antigen processing and presentation of endogenous antigen (GO:0019883)5.02057211
31* regulation of gamma-delta T cell activation (GO:0046643)5.00930328
32regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.85872649
33V(D)J recombination (GO:0033151)4.82103119
34* antigen receptor-mediated signaling pathway (GO:0050851)4.78182569
35regulation of B cell receptor signaling pathway (GO:0050855)4.58911065
36regulation of interleukin-2 biosynthetic process (GO:0045076)4.54663377
37regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.50063566
38DNA deamination (GO:0045006)4.39275369
39positive regulation of tolerance induction (GO:0002645)4.36959466
40positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.36812374
41positive regulation of natural killer cell mediated immunity (GO:0002717)4.36812374
42negative regulation of T cell apoptotic process (GO:0070233)4.35811343
43regulation of alpha-beta T cell proliferation (GO:0046640)4.30954402
44regulation of natural killer cell mediated immunity (GO:0002715)4.27156377
45regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.27156377
46positive regulation of alpha-beta T cell proliferation (GO:0046641)4.27025601
47positive regulation of interleukin-2 production (GO:0032743)4.25048738
48regulation of regulatory T cell differentiation (GO:0045589)4.23891496
49positive regulation of isotype switching (GO:0045830)4.23034717
50mast cell activation (GO:0045576)4.16836017
51regulation of T cell mediated cytotoxicity (GO:0001914)4.10415630
52sequestering of actin monomers (GO:0042989)4.10258600
53positive regulation of T cell mediated cytotoxicity (GO:0001916)4.08560748
54tolerance induction (GO:0002507)4.04914981
55* T cell differentiation (GO:0030217)3.99745950
56regulation of isotype switching (GO:0045191)3.98292855
57alpha-beta T cell differentiation (GO:0046632)3.98075830
58positive regulation of B cell differentiation (GO:0045579)3.93005766
59alpha-beta T cell activation (GO:0046631)3.92254335
60* regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.92011694
61negative regulation of T cell mediated immunity (GO:0002710)3.91476278
62* regulation of T cell receptor signaling pathway (GO:0050856)3.90139444
63regulation of tolerance induction (GO:0002643)3.81868429
64positive regulation of DNA recombination (GO:0045911)3.69747535
65regulation of response to interferon-gamma (GO:0060330)3.65109337
66lymphocyte chemotaxis (GO:0048247)3.64434965
67regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.63112458
68positive regulation of immunoglobulin mediated immune response (GO:0002891)3.62431651
69positive regulation of B cell mediated immunity (GO:0002714)3.62431651
70regulation of leukocyte mediated cytotoxicity (GO:0001910)3.61947380
71positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.61273711
72* T cell activation (GO:0042110)3.60964908
73positive regulation of humoral immune response (GO:0002922)3.58923163
74regulation of immunoglobulin mediated immune response (GO:0002889)3.57666764
75Peyers patch development (GO:0048541)3.56863712
76mucosal-associated lymphoid tissue development (GO:0048537)3.56863712
77T cell homeostasis (GO:0043029)3.51656484
78Arp2/3 complex-mediated actin nucleation (GO:0034314)3.51576260
79negative regulation of T cell receptor signaling pathway (GO:0050860)3.48976494
80regulation of B cell mediated immunity (GO:0002712)3.45837314
81negative regulation of leukocyte mediated immunity (GO:0002704)3.40648127
82leukocyte cell-cell adhesion (GO:0007159)3.39949019
83negative regulation of lymphocyte mediated immunity (GO:0002707)3.37888511
84negative regulation of thymocyte apoptotic process (GO:0070244)3.37409168
85regulation of cell killing (GO:0031341)3.37205019
86negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.36837265
87positive regulation of cell killing (GO:0031343)3.36781309
88positive regulation of defense response to virus by host (GO:0002230)3.33926333
89mast cell activation involved in immune response (GO:0002279)3.33618575
90mast cell degranulation (GO:0043303)3.33618575
91regulation of interleukin-12 biosynthetic process (GO:0045075)3.32744030
92cellular response to interleukin-4 (GO:0071353)3.31938113
93positive regulation of calcium-mediated signaling (GO:0050850)3.31548714
94* immune response-activating cell surface receptor signaling pathway (GO:0002429)3.30666967
95natural killer cell activation (GO:0030101)3.29674166
96regulation of interleukin-2 production (GO:0032663)3.28603472
97positive regulation of immunoglobulin production (GO:0002639)3.28554613
98regulation of immunoglobulin production (GO:0002637)3.28552193
99antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.28291815
100immunoglobulin mediated immune response (GO:0016064)3.25625029
101type I interferon signaling pathway (GO:0060337)3.25527335
102cellular response to type I interferon (GO:0071357)3.25527335
103regulation of alpha-beta T cell activation (GO:0046634)3.24292801
104positive regulation of interleukin-4 production (GO:0032753)3.23917404
105response to type I interferon (GO:0034340)3.23546462
106positive regulation of T cell mediated immunity (GO:0002711)3.21507351
107* B cell receptor signaling pathway (GO:0050853)3.20538186
108regulation of B cell differentiation (GO:0045577)3.20395825
109regulation of type I interferon-mediated signaling pathway (GO:0060338)3.18807319
110positive regulation of T cell differentiation in thymus (GO:0033089)3.18690228
111regulation of T cell apoptotic process (GO:0070232)3.14892736
112positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.14439637
113negative regulation of viral genome replication (GO:0045071)3.14082047
114heterotypic cell-cell adhesion (GO:0034113)3.12874480
115antigen processing and presentation via MHC class Ib (GO:0002475)3.12493408
116positive regulation of alpha-beta T cell activation (GO:0046635)3.12280325
117* positive regulation of T cell activation (GO:0050870)3.12082225
118negative regulation of lymphocyte apoptotic process (GO:0070229)3.11888461
119dendritic cell chemotaxis (GO:0002407)3.10948919
120positive regulation of lymphocyte mediated immunity (GO:0002708)3.10207246
121leukocyte degranulation (GO:0043299)3.09087255
122T-helper cell differentiation (GO:0042093)3.08282015
123CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.08282015
124T cell proliferation (GO:0042098)3.07979770
125lymphocyte migration (GO:0072676)3.06836939
126regulation of T cell mediated immunity (GO:0002709)3.05159196
127positive regulation of granulocyte differentiation (GO:0030854)3.04356450
128alpha-beta T cell differentiation involved in immune response (GO:0002293)3.01398860
129alpha-beta T cell activation involved in immune response (GO:0002287)3.01398860
130T cell differentiation involved in immune response (GO:0002292)3.01398860
131cellular defense response (GO:0006968)2.99903964
132response to interleukin-4 (GO:0070670)2.99117192
133regulation of activation of Janus kinase activity (GO:0010533)2.97876339
134lymphocyte homeostasis (GO:0002260)2.97025902
135regulation of lymphocyte mediated immunity (GO:0002706)2.96860327
136actin nucleation (GO:0045010)2.93240128

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.29394557
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.75728356
3E2F7_22180533_ChIP-Seq_HELA_Human5.20888492
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.68369378
5MYC_22102868_ChIP-Seq_BL_Human3.61093699
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.58008372
7RUNX_20019798_ChIP-Seq_JUKART_Human3.46615718
8FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.39269496
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.36877770
10STAT4_19710469_ChIP-ChIP_TH1__Mouse3.28680486
11* MYB_26560356_Chip-Seq_TH2_Human3.23482475
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.14723168
13* MAF_26560356_Chip-Seq_TH1_Human2.82532690
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.75309207
15* UTX_26944678_Chip-Seq_JUKART_Human2.75195310
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.67560701
17MYB_26560356_Chip-Seq_TH1_Human2.65569131
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.53445689
19* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.28887818
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.25483756
21VDR_21846776_ChIP-Seq_THP-1_Human2.15785216
22NOTCH1_21737748_ChIP-Seq_TLL_Human2.12499935
23IRF8_21731497_ChIP-ChIP_J774_Mouse2.12453806
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.11272617
25* MAF_26560356_Chip-Seq_TH2_Human2.05466319
26GATA3_27048872_Chip-Seq_THYMUS_Human2.04281976
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.01321185
28FOXM1_23109430_ChIP-Seq_U2OS_Human1.99763359
29KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.90449327
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.87263496
31RUNX1_22412390_ChIP-Seq_EML_Mouse1.86464184
32E2F4_17652178_ChIP-ChIP_JURKAT_Human1.82881458
33SPI1_23547873_ChIP-Seq_NB4_Human1.82473172
34TCF7_22412390_ChIP-Seq_EML_Mouse1.73335931
35* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.70354878
36* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.70329013
37CIITA_25753668_ChIP-Seq_RAJI_Human1.69073703
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.68172008
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.63908313
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.60168129
41VDR_23849224_ChIP-Seq_CD4+_Human1.58955008
42SCL_19346495_ChIP-Seq_HPC-7_Human1.54573364
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.52860371
44FOXP3_21729870_ChIP-Seq_TREG_Human1.51542372
45MYB_21317192_ChIP-Seq_ERMYB_Mouse1.51190543
46VDR_24763502_ChIP-Seq_THP-1_Human1.50955746
47NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49358454
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.49060642
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.46442883
50SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45485030
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.42991037
52KDM2B_26808549_Chip-Seq_DND41_Human1.40884981
53IRF8_27001747_Chip-Seq_BMDM_Mouse1.37778838
54* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.30383876
55FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.25623488
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.24340620
57* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21014986
58GABP_17652178_ChIP-ChIP_JURKAT_Human1.19131759
59SPI1_23127762_ChIP-Seq_K562_Human1.19067327
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17248723
61GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.17215013
62EST1_17652178_ChIP-ChIP_JURKAT_Human1.16646925
63BCL6_27268052_Chip-Seq_Bcells_Human1.15498866
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13358847
65CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13099781
66GATA3_26560356_Chip-Seq_TH2_Human1.11806309
67FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11069699
68HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.08251910
69XRN2_22483619_ChIP-Seq_HELA_Human1.06211106
70VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04255737
71MYC_18555785_ChIP-Seq_MESCs_Mouse1.03570291
72TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03121638
73ELK1_19687146_ChIP-ChIP_HELA_Human1.02347853
74CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01603178
75RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00544393
76GATA3_26560356_Chip-Seq_TH1_Human0.99917138
77PU_27001747_Chip-Seq_BMDM_Mouse0.97330427
78PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96875399
79LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95575020
80KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95351943
81MYC_19079543_ChIP-ChIP_MESCs_Mouse0.95072793
82VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94891212
83ELK3_25401928_ChIP-Seq_HUVEC_Human0.94682065
84SMAD_19615063_ChIP-ChIP_OVARY_Human0.94037479
85CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93402450
86RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.92852603
87EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.92818735
88NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.92755067
89CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92633591
90FLI1_27457419_Chip-Seq_LIVER_Mouse0.92512887
91FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.92080131
92RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91864562
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91132503
94P300_27268052_Chip-Seq_Bcells_Human0.90139027
95FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88957682
96* BCOR_27268052_Chip-Seq_Bcells_Human0.88159760
97SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.87974333
98KDM2B_26808549_Chip-Seq_JURKAT_Human0.87947753
99PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87356662
100TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.86929669
101CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86156610
102LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.85465156
103ELF1_20517297_ChIP-Seq_JURKAT_Human0.85031342
104SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84968777
105ETS1_20019798_ChIP-Seq_JURKAT_Human0.83661934
106* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.81713249
107KDM5A_27292631_Chip-Seq_BREAST_Human0.81680996
108* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80966507
109JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.79929579
110GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.79362207
111RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79243288
112SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.79095447
113MYC_18358816_ChIP-ChIP_MESCs_Mouse0.77532213
114GABP_19822575_ChIP-Seq_HepG2_Human0.77068313
115PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76203470
116CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.76104788
117E2F1_21310950_ChIP-Seq_MCF-7_Human0.75771376
118GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75723640
119* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.74251440
120GATA1_19941827_ChIP-Seq_MEL_Mouse0.73339094
121VDR_24787735_ChIP-Seq_THP-1_Human0.72046514
122CTCF_26484167_Chip-Seq_Bcells_Mouse0.71997741
123* SA1_27219007_Chip-Seq_Bcells_Human0.67464318

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003763_abnormal_thymus_physiology5.97316678
2MP0005671_abnormal_response_to5.07472806
3MP0000685_abnormal_immune_system3.69514341
4MP0002166_altered_tumor_susceptibility3.44783597
5MP0001835_abnormal_antigen_presentation3.18616425
6* MP0000703_abnormal_thymus_morphology3.12658901
7* MP0002398_abnormal_bone_marrow3.02159711
8* MP0001800_abnormal_humoral_immune3.02137196
9MP0009333_abnormal_splenocyte_physiolog2.99515415
10MP0009785_altered_susceptibility_to2.87998170
11MP0002006_tumorigenesis2.87913985
12* MP0002420_abnormal_adaptive_immunity2.86118040
13MP0005000_abnormal_immune_tolerance2.85130769
14* MP0001819_abnormal_immune_cell2.81359950
15MP0001790_abnormal_immune_system2.79084664
16MP0005387_immune_system_phenotype2.79084664
17* MP0002723_abnormal_immune_serum2.72082231
18MP0006082_CNS_inflammation2.66100915
19MP0002405_respiratory_system_inflammati2.61606524
20* MP0000716_abnormal_immune_system2.56148702
21* MP0002722_abnormal_immune_system2.51118147
22MP0005025_abnormal_response_to2.42015530
23* MP0002452_abnormal_antigen_presenting2.41565329
24MP0000689_abnormal_spleen_morphology2.36679517
25MP0001873_stomach_inflammation2.36157350
26MP0010155_abnormal_intestine_physiology2.29272610
27MP0004947_skin_inflammation2.27140439
28MP0002396_abnormal_hematopoietic_system2.25260265
29MP0002933_joint_inflammation2.22135575
30MP0003724_increased_susceptibility_to2.12305514
31* MP0002429_abnormal_blood_cell2.09242202
32MP0003866_abnormal_defecation2.04697708
33MP0003436_decreased_susceptibility_to2.01725753
34MP0002148_abnormal_hypersensitivity_rea1.85354761
35MP0004381_abnormal_hair_follicle1.82836103
36MP0002132_abnormal_respiratory_system1.77585840
37MP0003300_gastrointestinal_ulcer1.75598167
38MP0002419_abnormal_innate_immunity1.64034401
39MP0001845_abnormal_inflammatory_respons1.62958607
40MP0000858_altered_metastatic_potential1.59877475
41MP0004808_abnormal_hematopoietic_stem1.54236189
42MP0005464_abnormal_platelet_physiology1.51871878
43MP0010094_abnormal_chromosome_stability1.42306578
44MP0001853_heart_inflammation1.33433128
45MP0003693_abnormal_embryo_hatching1.33169039
46MP0005310_abnormal_salivary_gland1.30569480
47MP0008057_abnormal_DNA_replication1.30261712
48MP0002019_abnormal_tumor_incidence1.28347793
49MP0005075_abnormal_melanosome_morpholog1.28268207
50MP0000490_abnormal_crypts_of1.24629126
51MP0002009_preneoplasia1.24355357
52MP0003448_altered_tumor_morphology1.21759009
53MP0004510_myositis1.17421734
54MP0003077_abnormal_cell_cycle1.16363274
55MP0002277_abnormal_respiratory_mucosa1.14757908
56MP0004957_abnormal_blastocyst_morpholog1.03573346
57MP0000465_gastrointestinal_hemorrhage1.03193620
58MP0008469_abnormal_protein_level1.01700179
59MP0001545_abnormal_hematopoietic_system1.01299448
60MP0005397_hematopoietic_system_phenotyp1.01299448
61MP0010352_gastrointestinal_tract_polyps1.01087815
62MP0001851_eye_inflammation0.94780630
63MP0001919_abnormal_reproductive_system0.93147485
64MP0000569_abnormal_digit_pigmentation0.90187130
65MP0003111_abnormal_nucleus_morphology0.90156219
66MP0003303_peritoneal_inflammation0.85873817
67MP0008058_abnormal_DNA_repair0.85388523
68MP0001533_abnormal_skeleton_physiology0.84122663
69MP0003172_abnormal_lysosome_physiology0.80716739
70MP0005174_abnormal_tail_pigmentation0.80354828
71MP0008007_abnormal_cellular_replicative0.80142983
72MP0005408_hypopigmentation0.79692849
73MP0009278_abnormal_bone_marrow0.79333523
74MP0001243_abnormal_dermal_layer0.76205739
75MP0005023_abnormal_wound_healing0.74554206
76MP0002998_abnormal_bone_remodeling0.71115775
77MP0000371_diluted_coat_color0.69102949
78MP0005166_decreased_susceptibility_to0.68728142
79MP0002095_abnormal_skin_pigmentation0.67729191
80MP0000015_abnormal_ear_pigmentation0.66518588
81MP0001986_abnormal_taste_sensitivity0.64958494
82MP0009763_increased_sensitivity_to0.62719892
83MP0000477_abnormal_intestine_morphology0.62036750
84MP0003252_abnormal_bile_duct0.62003695
85MP0003045_fibrosis0.60700480
86MP0002254_reproductive_system_inflammat0.60190233
87MP0009765_abnormal_xenobiotic_induced0.59491736
88MP0003786_premature_aging0.58463338
89MP0008961_abnormal_basal_metabolism0.57825321
90MP0000313_abnormal_cell_death0.57782255
91MP0004130_abnormal_muscle_cell0.56993125
92MP0003183_abnormal_peptide_metabolism0.55713784
93MP0001191_abnormal_skin_condition0.54115369
94MP0000350_abnormal_cell_proliferation0.50403486
95MP0005076_abnormal_cell_differentiation0.49774069
96MP0002136_abnormal_kidney_physiology0.49083196
97MP0000604_amyloidosis0.48619566
98MP0000609_abnormal_liver_physiology0.48474401
99MP0005377_hearing/vestibular/ear_phenot0.47609868
100MP0003878_abnormal_ear_physiology0.47609868
101MP0005409_darkened_coat_color0.47559929
102MP0003795_abnormal_bone_structure0.47114535
103MP0001765_abnormal_ion_homeostasis0.46852532
104MP0002163_abnormal_gland_morphology0.46522010
105MP0005390_skeleton_phenotype0.46132962
106MP0001348_abnormal_lacrimal_gland0.45894003
107MP0001730_embryonic_growth_arrest0.44505864
108MP0002083_premature_death0.42709339
109MP0001216_abnormal_epidermal_layer0.42198930
110MP0000367_abnormal_coat/_hair0.42110241
111MP0008877_abnormal_DNA_methylation0.42055945
112MP0004883_abnormal_blood_vessel0.41556566
113MP0001663_abnormal_digestive_system0.40542055
114MP0008873_increased_physiological_sensi0.39318667
115MP0009764_decreased_sensitivity_to0.38600356
116MP0002138_abnormal_hepatobiliary_system0.38308757
117MP0002693_abnormal_pancreas_physiology0.38151010
118MP0002822_catalepsy0.36616019
119MP0008770_decreased_survivor_rate0.36590672
120MP0010307_abnormal_tumor_latency0.36205983
121MP0009642_abnormal_blood_homeostasis0.35409508
122MP0008872_abnormal_physiological_respon0.34482184
123MP0001119_abnormal_female_reproductive0.34131833
124MP0005379_endocrine/exocrine_gland_phen0.34064563
125MP0005645_abnormal_hypothalamus_physiol0.33780509
126MP0000249_abnormal_blood_vessel0.33491564

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)9.79852544
2Abnormality of T cell number (HP:0011839)9.41548473
3Severe combined immunodeficiency (HP:0004430)7.74468904
4Combined immunodeficiency (HP:0005387)7.19726901
5Abnormality of T cells (HP:0002843)6.18903658
6Panhypogammaglobulinemia (HP:0003139)5.64100176
7Abnormality of B cell number (HP:0010975)5.61247440
8B lymphocytopenia (HP:0010976)5.61247440
9Thyroiditis (HP:0100646)5.56248053
10IgG deficiency (HP:0004315)5.19625355
11Elevated erythrocyte sedimentation rate (HP:0003565)5.17293814
12Hypoplasia of the thymus (HP:0000778)5.06232116
13Abnormality of eosinophils (HP:0001879)4.93937873
14Recurrent viral infections (HP:0004429)4.92417202
15Eosinophilia (HP:0001880)4.85421075
16Recurrent bronchitis (HP:0002837)4.81641610
17Recurrent fungal infections (HP:0002841)4.69369932
18Autoimmune hemolytic anemia (HP:0001890)4.31596500
19Stomatitis (HP:0010280)4.25549427
20Granulocytopenia (HP:0001913)4.16489011
21IgM deficiency (HP:0002850)4.15564780
22Leukocytosis (HP:0001974)3.99389458
23Recurrent cutaneous fungal infections (HP:0011370)3.86960466
24Chronic mucocutaneous candidiasis (HP:0002728)3.86960466
25Nasal polyposis (HP:0100582)3.86292584
26Increased IgM level (HP:0003496)3.83499317
27Chronic otitis media (HP:0000389)3.75450072
28Abnormality of macrophages (HP:0004311)3.56849671
29Myositis (HP:0100614)3.45260224
30Lymphopenia (HP:0001888)3.42328009
31Aplastic anemia (HP:0001915)3.39804561
32Chronic diarrhea (HP:0002028)3.39525910
33Abnormality of the fingertips (HP:0001211)3.38657096
34Abnormality of cells of the lymphoid lineage (HP:0012140)3.35120539
35Pustule (HP:0200039)3.33609631
36Recurrent bacterial skin infections (HP:0005406)3.31062909
37Eczematoid dermatitis (HP:0000976)3.30865164
38Abnormal delayed hypersensitivity skin test (HP:0002963)3.27835102
39Joint swelling (HP:0001386)3.24484664
40Abnormality of the nasal mucosa (HP:0000433)3.21086895
41Abnormality of T cell physiology (HP:0011840)3.15230323
42Lymphoma (HP:0002665)2.96758504
43Meningitis (HP:0001287)2.93035373
44Autoimmune thrombocytopenia (HP:0001973)2.87013336
45Gastrointestinal stroma tumor (HP:0100723)2.86862392
46Bronchitis (HP:0012387)2.73546634
47Hypoproteinemia (HP:0003075)2.68402556
48Basal cell carcinoma (HP:0002671)2.62329781
49Encephalitis (HP:0002383)2.56431178
50Optic neuritis (HP:0100653)2.54316847
51Retrobulbar optic neuritis (HP:0100654)2.54316847
52IgA deficiency (HP:0002720)2.51315462
53Recurrent sinusitis (HP:0011108)2.50251875
54Hypergammaglobulinemia (HP:0010702)2.47529052
55Aplasia/Hypoplasia of the thymus (HP:0010515)2.45111795
56Vasculitis (HP:0002633)2.41227206
57Hemoptysis (HP:0002105)2.40123379
58Gastrointestinal infarctions (HP:0005244)2.35183915
59Agammaglobulinemia (HP:0004432)2.33497175
60Recurrent otitis media (HP:0000403)2.27568720
61Stomach cancer (HP:0012126)2.25767190
62Verrucae (HP:0200043)2.22898033
63Papilloma (HP:0012740)2.22898033
64Orchitis (HP:0100796)2.20415629
65Pulmonary infiltrates (HP:0002113)2.18291203
66Recurrent skin infections (HP:0001581)2.15222536
67Abnormality of the pleura (HP:0002103)2.12960711
68Hypochromic anemia (HP:0001931)2.10294158
69Recurrent abscess formation (HP:0002722)2.10116277
70Keratoconjunctivitis sicca (HP:0001097)2.09715413
71Gastrointestinal inflammation (HP:0004386)2.09695215
72Inflammation of the large intestine (HP:0002037)2.09512632
73Anorexia (HP:0002039)2.07715814
74Mediastinal lymphadenopathy (HP:0100721)2.06690226
75Acute hepatic failure (HP:0006554)2.06308868
76Recurrent gram-negative bacterial infections (HP:0005420)2.06146477
77Thrombocytosis (HP:0001894)2.05334322
78Spontaneous hematomas (HP:0007420)2.05283653
79Chronic obstructive pulmonary disease (HP:0006510)2.03541301
80Obstructive lung disease (HP:0006536)2.03541301
81Chronic sinusitis (HP:0011109)2.01460794
82Urticaria (HP:0001025)1.95226489
83Restrictive lung disease (HP:0002091)1.92691644
84Cellular immunodeficiency (HP:0005374)1.92161019
85Bronchiectasis (HP:0002110)1.91346063
86Increased IgE level (HP:0003212)1.90202873
87Abnormality of the prostate (HP:0008775)1.89707104
88Skin rash (HP:0000988)1.89406941
89Abnormality of the thymus (HP:0000777)1.89251007
90Keratoconjunctivitis (HP:0001096)1.89044044
91Pulmonary fibrosis (HP:0002206)1.86993629
92Hemiplegia (HP:0002301)1.85424860
93Ureteral stenosis (HP:0000071)1.79844016
94Poikiloderma (HP:0001029)1.79453828
95Amaurosis fugax (HP:0100576)1.77647889
96Prostate neoplasm (HP:0100787)1.77017842
97Neutropenia (HP:0001875)1.76340445
98Trigonocephaly (HP:0000243)1.76227938
99Recurrent pneumonia (HP:0006532)1.75854102
100Colitis (HP:0002583)1.73718919
101Arthralgia (HP:0002829)1.72423819
102Cheilitis (HP:0100825)1.71085043
103Abnormality of the peritoneum (HP:0002585)1.70570777
104Epistaxis (HP:0000421)1.70454437
105Arterial thrombosis (HP:0004420)1.70385066
106Glomerulopathy (HP:0100820)1.69617912
107Keratitis (HP:0000491)1.68081473
108Bicuspid aortic valve (HP:0001647)1.67792896
109Pancytopenia (HP:0001876)1.67013602
110Pulmonary embolism (HP:0002204)1.64031567
111Abnormality of oral frenula (HP:0000190)1.63845643
112Abnormal platelet volume (HP:0011876)1.60947089
113Ureteral obstruction (HP:0006000)1.59281685
114Gangrene (HP:0100758)1.56821742
115Skin ulcer (HP:0200042)1.56468305
116Amyotrophic lateral sclerosis (HP:0007354)1.56203816
117Chest pain (HP:0100749)1.55916329
118Prolonged bleeding time (HP:0003010)1.55497696
119Hepatitis (HP:0012115)1.53249783
120Entropion (HP:0000621)1.52543375
121Dislocated radial head (HP:0003083)1.50884948
122Sepsis (HP:0100806)1.50410441
123Muscle fiber atrophy (HP:0100295)1.50036935
124Prominent nose (HP:0000448)1.49150857

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.62058177
2MAP4K15.89980894
3ZAP703.80468640
4ITK3.36489838
5JAK32.85577621
6FGFR42.71605374
7STK102.64818543
8IKBKE2.45457299
9NLK2.44299585
10GRK62.43703039
11RIPK42.40044630
12TESK22.39217342
13TYK22.35524002
14TAOK32.25455300
15KDR2.21942362
16MST42.16527770
17* LCK1.91329382
18JAK11.74331847
19FGFR31.72799796
20NME21.61584080
21MAP3K141.57467398
22TEC1.53097688
23MAP3K101.52106685
24EEF2K1.48433112
25TBK11.44846600
26HCK1.40855770
27BTK1.38819273
28CLK11.27617237
29PRPF4B1.26798245
30* SYK1.25794406
31BLK1.21298536
32PRKCQ1.19963166
33PRKCH1.16046212
34LRRK21.08678029
35CAMKK21.03884308
36CDC71.03637940
37CAMKK10.94526347
38PKN20.94452574
39MAP3K110.92870151
40TNK20.88569959
41IRAK40.88405755
42PDGFRB0.87954647
43MARK30.87674288
44MAP3K120.85848064
45SIK20.85105695
46MAP3K70.84740065
47LYN0.78571445
48PIM10.78231824
49RPS6KA40.76210306
50KIT0.75297250
51CDK120.74606704
52IKBKB0.74556200
53STK40.73185512
54MAP3K130.71804923
55CDK40.71105303
56JAK20.70221323
57ARAF0.69696799
58* CSK0.67332156
59MAP3K90.66469027
60TESK10.65147356
61ERN10.64200964
62MAP4K20.63918532
63ADRBK20.61674023
64TYRO30.61175662
65FES0.59585016
66PASK0.58430849
67BRD40.55626080
68NEK20.55499999
69SIK30.54909176
70TSSK60.54305844
71CHUK0.54133780
72FGFR10.53926207
73TRIB30.53027593
74GRK70.52439839
75NUAK10.51498027
76MAP2K20.51297639
77ZAK0.51190647
78BUB10.50991692
79MAPK70.50063291
80CSF1R0.48835291
81MARK20.48481353
82SCYL20.47519363
83MAPK110.45496051
84MAP3K10.43311705
85KSR20.42690359
86MELK0.42635408
87FGR0.41885899
88TGFBR20.41571170
89SMG10.41075145
90TLK10.40826286
91MAP2K30.40335640
92FGFR20.39110642
93* INSR0.38920405
94SRPK10.38852258
95RPS6KB20.38403789
96ALK0.37938334
97EPHB10.36705650
98HIPK20.36116644
99ACVR1B0.36069989
100* FYN0.35908582
101ATR0.35664401
102FLT30.35573727
103MUSK0.34973383
104TGFBR10.34499021
105CDK90.34048760
106MAP2K60.33869342
107PDK10.33471367
108IGF1R0.32450048
109MAPKAPK20.30733327
110RAF10.30274298
111MAP3K80.29176008
112CDK60.29129460
113VRK10.28548814
114MAPK40.27869009
115EPHA30.27631987
116PRKCI0.26679358
117EIF2AK10.26343367
118BCKDK0.25751009
119MAPK120.24496415
120MAP3K30.23806795
121VRK20.23703113
122IRAK10.23485137
123TAOK10.23044449
124WNK40.22991788
125ILK0.22919046
126CHEK10.22904717
127PIK3CG0.22635136
128AURKB0.22381071
129PRKD20.22333557
130CDK190.21594017
131TTN0.21497920
132BMPR20.21467764
133CSNK1A1L0.21194753
134TAOK20.19560001
135RPS6KA50.19441164
136PIK3CA0.19273970

Predicted pathways (KEGG)

RankGene SetZ-score
1* Primary immunodeficiency_Homo sapiens_hsa053406.46104001
2* T cell receptor signaling pathway_Homo sapiens_hsa046604.07024382
3* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.16392778
4Graft-versus-host disease_Homo sapiens_hsa053323.10466384
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.95391504
6Antigen processing and presentation_Homo sapiens_hsa046122.91333096
7Measles_Homo sapiens_hsa051622.83542099
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.77906951
9Hematopoietic cell lineage_Homo sapiens_hsa046402.47655066
10Allograft rejection_Homo sapiens_hsa053302.44694042
11Non-homologous end-joining_Homo sapiens_hsa034502.11917923
12* NF-kappa B signaling pathway_Homo sapiens_hsa040642.07004820
13Viral myocarditis_Homo sapiens_hsa054161.86447639
14Autoimmune thyroid disease_Homo sapiens_hsa053201.75249436
15Leishmaniasis_Homo sapiens_hsa051401.59437869
16DNA replication_Homo sapiens_hsa030301.56866846
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.56808703
18Herpes simplex infection_Homo sapiens_hsa051681.54392025
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.51583940
20Ribosome_Homo sapiens_hsa030101.46229527
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.40834480
22B cell receptor signaling pathway_Homo sapiens_hsa046621.40788841
23Spliceosome_Homo sapiens_hsa030401.36841176
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.32381986
25Mismatch repair_Homo sapiens_hsa034301.31227924
26Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.31068488
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.30820737
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28569325
29* Osteoclast differentiation_Homo sapiens_hsa043801.27912576
30Acute myeloid leukemia_Homo sapiens_hsa052211.23188100
31Chemokine signaling pathway_Homo sapiens_hsa040621.19257328
32Hepatitis B_Homo sapiens_hsa051611.15526674
33* HTLV-I infection_Homo sapiens_hsa051661.12865447
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09881864
35Type I diabetes mellitus_Homo sapiens_hsa049401.09797196
36Shigellosis_Homo sapiens_hsa051311.07949266
37Colorectal cancer_Homo sapiens_hsa052101.06824705
38Base excision repair_Homo sapiens_hsa034101.01993150
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00922347
40Toxoplasmosis_Homo sapiens_hsa051450.99242063
41Proteasome_Homo sapiens_hsa030500.94595159
42Influenza A_Homo sapiens_hsa051640.94477292
43NOD-like receptor signaling pathway_Homo sapiens_hsa046210.91543121
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90395051
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.89351141
46Epstein-Barr virus infection_Homo sapiens_hsa051690.88498808
47Nucleotide excision repair_Homo sapiens_hsa034200.85753402
48Apoptosis_Homo sapiens_hsa042100.85312240
49Pancreatic cancer_Homo sapiens_hsa052120.85091791
50RNA degradation_Homo sapiens_hsa030180.84879835
51Viral carcinogenesis_Homo sapiens_hsa052030.83906740
52Thyroid cancer_Homo sapiens_hsa052160.81641589
53Chronic myeloid leukemia_Homo sapiens_hsa052200.78046726
54p53 signaling pathway_Homo sapiens_hsa041150.76039996
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75478579
56Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74136113
57TNF signaling pathway_Homo sapiens_hsa046680.72207863
58Homologous recombination_Homo sapiens_hsa034400.71201737
59Cell cycle_Homo sapiens_hsa041100.70497128
60mRNA surveillance pathway_Homo sapiens_hsa030150.69492618
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66991101
62Legionellosis_Homo sapiens_hsa051340.66459775
63Platelet activation_Homo sapiens_hsa046110.66068023
64Malaria_Homo sapiens_hsa051440.65519859
65RNA transport_Homo sapiens_hsa030130.63193388
66Hepatitis C_Homo sapiens_hsa051600.63160395
67VEGF signaling pathway_Homo sapiens_hsa043700.61179291
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60198097
69Systemic lupus erythematosus_Homo sapiens_hsa053220.59883500
70Asthma_Homo sapiens_hsa053100.54963705
71African trypanosomiasis_Homo sapiens_hsa051430.54511291
72Prolactin signaling pathway_Homo sapiens_hsa049170.52162062
73Salmonella infection_Homo sapiens_hsa051320.51752914
74Notch signaling pathway_Homo sapiens_hsa043300.51292895
75Non-small cell lung cancer_Homo sapiens_hsa052230.50345354
76Fanconi anemia pathway_Homo sapiens_hsa034600.49682422
77Staphylococcus aureus infection_Homo sapiens_hsa051500.49272955
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47220922
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46990959
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45090042
81Tuberculosis_Homo sapiens_hsa051520.43961799
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43748877
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42022242
84Endometrial cancer_Homo sapiens_hsa052130.41423881
85FoxO signaling pathway_Homo sapiens_hsa040680.41055881
86Pyrimidine metabolism_Homo sapiens_hsa002400.40733946
87Endocytosis_Homo sapiens_hsa041440.37940119
88Adherens junction_Homo sapiens_hsa045200.37255876
89Pertussis_Homo sapiens_hsa051330.37071407
90Small cell lung cancer_Homo sapiens_hsa052220.36562642
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36551484
92RNA polymerase_Homo sapiens_hsa030200.36019656
93Regulation of autophagy_Homo sapiens_hsa041400.35171527
94Linoleic acid metabolism_Homo sapiens_hsa005910.35011455
95Prostate cancer_Homo sapiens_hsa052150.33029501
96Basal transcription factors_Homo sapiens_hsa030220.32546585
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.31606073
98Rap1 signaling pathway_Homo sapiens_hsa040150.28912064
99Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.26262179
100One carbon pool by folate_Homo sapiens_hsa006700.25747506
101Caffeine metabolism_Homo sapiens_hsa002320.23893779
102Rheumatoid arthritis_Homo sapiens_hsa053230.22429011
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21692178
104Pathways in cancer_Homo sapiens_hsa052000.21406320
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.20929028
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.19578218
107Phagosome_Homo sapiens_hsa041450.18896810
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.17792212
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.17291928
110Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.17272096
111Choline metabolism in cancer_Homo sapiens_hsa052310.16688244
112mTOR signaling pathway_Homo sapiens_hsa041500.16133622
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.15980952
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.15338659
115Ras signaling pathway_Homo sapiens_hsa040140.15063158
116MAPK signaling pathway_Homo sapiens_hsa040100.14889328
117Prion diseases_Homo sapiens_hsa050200.14119819
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.12578746
119Insulin resistance_Homo sapiens_hsa049310.10174931
120Dorso-ventral axis formation_Homo sapiens_hsa043200.08435110
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.07763739

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