LCMT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A (PPP2CA; MIM 176915) (De Baere et al., 1999 [PubMed 10600115]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.83393014
2energy coupled proton transport, down electrochemical gradient (GO:0015985)4.60242468
3ATP synthesis coupled proton transport (GO:0015986)4.60242468
4synaptic vesicle exocytosis (GO:0016079)4.52652495
5neuron cell-cell adhesion (GO:0007158)4.47573828
6vocalization behavior (GO:0071625)4.17456662
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.15499648
8proteasome assembly (GO:0043248)4.12804045
9protein localization to synapse (GO:0035418)4.11077795
10chaperone-mediated protein transport (GO:0072321)3.92373335
11regulation of short-term neuronal synaptic plasticity (GO:0048172)3.86583088
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.84887233
13respiratory chain complex IV assembly (GO:0008535)3.78326944
14regulation of synaptic vesicle exocytosis (GO:2000300)3.70621913
15glutamate secretion (GO:0014047)3.70391150
16negative regulation of microtubule polymerization (GO:0031115)3.68906813
17respiratory electron transport chain (GO:0022904)3.64443569
18electron transport chain (GO:0022900)3.59900932
19energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.55910657
20ATP hydrolysis coupled proton transport (GO:0015991)3.55910657
21neuronal action potential propagation (GO:0019227)3.47304226
22negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.45525660
23positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.45006423
24neuron-neuron synaptic transmission (GO:0007270)3.41610401
25regulation of glutamate receptor signaling pathway (GO:1900449)3.38717790
26synaptic transmission, glutamatergic (GO:0035249)3.35667972
27regulation of synaptic vesicle transport (GO:1902803)3.33821850
28protein complex biogenesis (GO:0070271)3.33568143
29cytochrome complex assembly (GO:0017004)3.32402913
30negative regulation of synaptic transmission, GABAergic (GO:0032229)3.30707122
31positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.29173442
32RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.28792933
33tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.28792933
34establishment of integrated proviral latency (GO:0075713)3.28122042
35regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.27593347
36positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.27320447
37regulation of glutamate secretion (GO:0014048)3.26038529
38presynaptic membrane assembly (GO:0097105)3.25604719
39gamma-aminobutyric acid signaling pathway (GO:0007214)3.25184826
40synaptic vesicle docking involved in exocytosis (GO:0016081)3.24906745
41regulation of mitochondrial translation (GO:0070129)3.24609551
42establishment of protein localization to mitochondrial membrane (GO:0090151)3.24111312
43neurotransmitter secretion (GO:0007269)3.23730450
44ionotropic glutamate receptor signaling pathway (GO:0035235)3.21445742
45regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.20752878
46DNA damage response, detection of DNA damage (GO:0042769)3.16918932
47glutamate receptor signaling pathway (GO:0007215)3.15772262
48mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.15623650
49mitochondrial respiratory chain complex I assembly (GO:0032981)3.15623650
50NADH dehydrogenase complex assembly (GO:0010257)3.15623650
51regulation of cellular amino acid metabolic process (GO:0006521)3.13698717
52ubiquinone biosynthetic process (GO:0006744)3.13227597
53negative regulation of ligase activity (GO:0051352)3.12408288
54negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.12408288
55water-soluble vitamin biosynthetic process (GO:0042364)3.11843738
56mitochondrial respiratory chain complex assembly (GO:0033108)3.11358331
57transcription elongation from RNA polymerase III promoter (GO:0006385)3.10397644
58termination of RNA polymerase III transcription (GO:0006386)3.10397644
59protein targeting to mitochondrion (GO:0006626)3.08846422
60anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.08107046
61positive regulation of synapse maturation (GO:0090129)3.07626945
62presynaptic membrane organization (GO:0097090)3.07031515
63postsynaptic membrane organization (GO:0001941)3.05572750
64cullin deneddylation (GO:0010388)3.05048804
65DNA double-strand break processing (GO:0000729)3.04284283
66behavioral fear response (GO:0001662)3.03129362
67behavioral defense response (GO:0002209)3.03129362
68neuron recognition (GO:0008038)3.00399599
69synaptic vesicle maturation (GO:0016188)2.99006534
70nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.98654146
71regulation of protein kinase A signaling (GO:0010738)2.98429792
72protein neddylation (GO:0045116)2.98367317
73establishment of protein localization to mitochondrion (GO:0072655)2.97984447
74synapsis (GO:0007129)2.97653892
75protein localization to mitochondrion (GO:0070585)2.96559592
76establishment of viral latency (GO:0019043)2.96551283
77ribosomal large subunit biogenesis (GO:0042273)2.95896483
78ubiquinone metabolic process (GO:0006743)2.95084104
79DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.95067666
80exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.94399432
81piRNA metabolic process (GO:0034587)2.94014125
82fear response (GO:0042596)2.93967973
83oxidative phosphorylation (GO:0006119)2.89459764
84transferrin transport (GO:0033572)2.87655216
85peptidyl-histidine modification (GO:0018202)2.87505555
86signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.85978998
87signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.85978998
88signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.85978998
89ribosomal small subunit assembly (GO:0000028)2.85538472
90chromatin remodeling at centromere (GO:0031055)2.84700564
91exploration behavior (GO:0035640)2.84195837
92protein deneddylation (GO:0000338)2.83968403
93base-excision repair, AP site formation (GO:0006285)2.83963054
94intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.83679319
95signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.83679319
96positive regulation of synapse assembly (GO:0051965)2.83429073
97positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.82886247
98hydrogen ion transmembrane transport (GO:1902600)2.82820574
99establishment of synaptic vesicle localization (GO:0097480)2.81965438
100synaptic vesicle transport (GO:0048489)2.81965438
101regulation of long-term neuronal synaptic plasticity (GO:0048169)2.81543383
102neurotransmitter transport (GO:0006836)2.81178613
103inner mitochondrial membrane organization (GO:0007007)2.80573026
104protein-cofactor linkage (GO:0018065)2.79479805
105ATP biosynthetic process (GO:0006754)2.78299315
106nonmotile primary cilium assembly (GO:0035058)2.78202300
107behavioral response to cocaine (GO:0048148)2.77174197
108signal transduction involved in cell cycle checkpoint (GO:0072395)2.76857565
109protein K11-linked ubiquitination (GO:0070979)2.75944108
110negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.75271549
111signal transduction involved in DNA damage checkpoint (GO:0072422)2.75198581
112signal transduction involved in DNA integrity checkpoint (GO:0072401)2.75198581
113platelet dense granule organization (GO:0060155)2.74858626
114positive regulation of ligase activity (GO:0051351)2.74288126
115DNA replication checkpoint (GO:0000076)2.73281355
116neurotransmitter-gated ion channel clustering (GO:0072578)2.72667494
117peptidyl-cysteine modification (GO:0018198)2.72389060
118transmission of nerve impulse (GO:0019226)2.71945881
119synaptic transmission, dopaminergic (GO:0001963)2.71671872
120dopamine transport (GO:0015872)2.70110840
121CENP-A containing nucleosome assembly (GO:0034080)2.70054787
122regulation of neuronal synaptic plasticity (GO:0048168)2.69532342
123synaptic vesicle endocytosis (GO:0048488)2.69458387
124iron-sulfur cluster assembly (GO:0016226)2.69010903
125metallo-sulfur cluster assembly (GO:0031163)2.69010903
126long-term memory (GO:0007616)2.68880364
127spliceosomal snRNP assembly (GO:0000387)2.68513836
128purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.67641472
129digestion (GO:0007586)2.66901452
130regulation of excitatory postsynaptic membrane potential (GO:0060079)2.66848514
131negative regulation of dendrite morphogenesis (GO:0050774)2.66841249
132long-term synaptic potentiation (GO:0060291)2.65941251
133positive regulation of neurotransmitter transport (GO:0051590)2.64957656
134serotonin receptor signaling pathway (GO:0007210)2.64840660
135mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.64711700
136purine nucleoside triphosphate biosynthetic process (GO:0009145)2.63565801
1377-methylguanosine mRNA capping (GO:0006370)2.62502915
138L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.61918923
139regulation of vesicle fusion (GO:0031338)2.61043821
140mannosylation (GO:0097502)2.60617353
141trivalent inorganic cation transport (GO:0072512)2.60254898
142ferric iron transport (GO:0015682)2.60254898
143positive regulation of neurotransmitter secretion (GO:0001956)2.60071106
144protein polyglutamylation (GO:0018095)2.59426749
145positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.58827943
146regulation of postsynaptic membrane potential (GO:0060078)2.58110717
147regulation of neurotransmitter levels (GO:0001505)2.57923425
148regulation of synapse structural plasticity (GO:0051823)2.56805272
149regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.56777798
150regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.56777798
151tRNA aminoacylation for protein translation (GO:0006418)2.56033340
152amino acid activation (GO:0043038)2.55972093
153tRNA aminoacylation (GO:0043039)2.55972093
154regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.55160164
155protein maturation by protein folding (GO:0022417)2.54835229
1567-methylguanosine RNA capping (GO:0009452)2.54467405
157RNA capping (GO:0036260)2.54467405
158positive regulation of membrane potential (GO:0045838)2.54203791
159regulation of neurotransmitter secretion (GO:0046928)2.53982361
160regulation of synapse maturation (GO:0090128)2.53791924
161single strand break repair (GO:0000012)2.52608679
162regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.52531271
163resolution of meiotic recombination intermediates (GO:0000712)2.52320328
164negative regulation of amino acid transport (GO:0051956)2.51539627
165startle response (GO:0001964)2.51204084
166regulation of ubiquitin-protein transferase activity (GO:0051438)2.50872221
167regulation of meiosis I (GO:0060631)2.49978497
168locomotory exploration behavior (GO:0035641)2.49939856
169intracellular protein transmembrane import (GO:0044743)2.46320210
170regulation of ligase activity (GO:0051340)2.45055784
171pyrimidine nucleobase catabolic process (GO:0006208)2.44921759
172aldehyde catabolic process (GO:0046185)2.44174054
173DNA catabolic process, exonucleolytic (GO:0000738)2.44014857
174proton transport (GO:0015992)2.43943600
175quinone biosynthetic process (GO:1901663)2.43060397
176somatic hypermutation of immunoglobulin genes (GO:0016446)2.42194589

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.71277566
2GBX2_23144817_ChIP-Seq_PC3_Human3.27677553
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.92088675
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.61959418
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.54654939
6REST_21632747_ChIP-Seq_MESCs_Mouse2.53385188
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.49656056
8TAF15_26573619_Chip-Seq_HEK293_Human2.44755363
9ELK1_19687146_ChIP-ChIP_HELA_Human2.33929131
10REST_18959480_ChIP-ChIP_MESCs_Mouse2.26348934
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.22239360
12THAP11_20581084_ChIP-Seq_MESCs_Mouse2.16810900
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.14309809
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.12061292
15CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.11324695
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.09816654
17* ETS1_20019798_ChIP-Seq_JURKAT_Human2.04428251
18PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02701556
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.02605362
20JARID2_20064375_ChIP-Seq_MESCs_Mouse2.01446898
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.99866710
22RARB_27405468_Chip-Seq_BRAIN_Mouse1.87686036
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.85377470
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81536377
25JARID2_20075857_ChIP-Seq_MESCs_Mouse1.80022817
26BMI1_23680149_ChIP-Seq_NPCS_Mouse1.77663636
27ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.77513465
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77054736
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.77052228
30EZH2_27304074_Chip-Seq_ESCs_Mouse1.74236653
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.71164155
32FUS_26573619_Chip-Seq_HEK293_Human1.69861016
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68951845
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68898846
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67507648
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.66675764
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.63843431
38ZNF274_21170338_ChIP-Seq_K562_Hela1.63257175
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61440664
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.60963084
41MYC_18555785_ChIP-Seq_MESCs_Mouse1.60095851
42SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.58662100
43E2F4_17652178_ChIP-ChIP_JURKAT_Human1.55186784
44RBPJ_22232070_ChIP-Seq_NCS_Mouse1.53720462
45SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.49840006
46EZH2_18974828_ChIP-Seq_MESCs_Mouse1.48340198
47RNF2_18974828_ChIP-Seq_MESCs_Mouse1.48340198
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.47463298
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.46613291
50SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.44416173
51XRN2_22483619_ChIP-Seq_HELA_Human1.44360775
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.43795741
53MTF2_20144788_ChIP-Seq_MESCs_Mouse1.42582086
54SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.41527859
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.41053565
56EED_16625203_ChIP-ChIP_MESCs_Mouse1.40829088
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.39144426
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.38380870
59ELF1_17652178_ChIP-ChIP_JURKAT_Human1.36959292
60CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.36215149
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36008094
62VDR_22108803_ChIP-Seq_LS180_Human1.34078156
63MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.33941391
64EWS_26573619_Chip-Seq_HEK293_Human1.32145769
65SUZ12_27294783_Chip-Seq_ESCs_Mouse1.30180435
66MYC_18358816_ChIP-ChIP_MESCs_Mouse1.30046468
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28408268
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27868074
69EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.27764604
70SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.26294711
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25702719
72SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.23893939
73PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23381044
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22229978
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21762540
76RNF2_27304074_Chip-Seq_NSC_Mouse1.21318187
77FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.20854524
78CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.20833552
79IKZF1_21737484_ChIP-ChIP_HCT116_Human1.20828848
80CBX2_27304074_Chip-Seq_ESCs_Mouse1.20604048
81FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.20539991
82MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20257769
83SOX2_16153702_ChIP-ChIP_HESCs_Human1.18483949
84HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16887415
85P300_19829295_ChIP-Seq_ESCs_Human1.16540336
86MYCN_18555785_ChIP-Seq_MESCs_Mouse1.14625924
87RNF2_27304074_Chip-Seq_ESCs_Mouse1.13960161
88TP53_22573176_ChIP-Seq_HFKS_Human1.13301012
89POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13016873
90POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11305591
91NANOG_16153702_ChIP-ChIP_HESCs_Human1.09796040
92IGF1R_20145208_ChIP-Seq_DFB_Human1.08211967
93POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.06994632
94ELK1_22589737_ChIP-Seq_MCF10A_Human1.06743459
95SMAD4_21799915_ChIP-Seq_A2780_Human1.06546916
96RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05773962
97TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05705547
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05640836
99FLI1_27457419_Chip-Seq_LIVER_Mouse1.05608804
100SRF_21415370_ChIP-Seq_HL-1_Mouse1.04008919
101NOTCH1_21737748_ChIP-Seq_TLL_Human1.01319276
102* IRF1_19129219_ChIP-ChIP_H3396_Human1.01246888
103DCP1A_22483619_ChIP-Seq_HELA_Human1.01037375
104YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00223621
105ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00166241
106MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98763033
107EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98706934
108MYC_19079543_ChIP-ChIP_MESCs_Mouse0.97389785
109MYC_19030024_ChIP-ChIP_MESCs_Mouse0.97246436
110REST_19997604_ChIP-ChIP_NEURONS_Mouse0.96419264
111* GABP_19822575_ChIP-Seq_HepG2_Human0.95948123
112JUN_21703547_ChIP-Seq_K562_Human0.94991800
113MYC_18940864_ChIP-ChIP_HL60_Human0.94782353
114HTT_18923047_ChIP-ChIP_STHdh_Human0.94280649
115VDR_23849224_ChIP-Seq_CD4+_Human0.93051957
116SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92645395
117OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92178207
118MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.91470377
119SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.90796403
120TTF2_22483619_ChIP-Seq_HELA_Human0.90095184
121CTCF_18555785_ChIP-Seq_MESCs_Mouse0.87873448
122* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.87220103
123SMAD3_21741376_ChIP-Seq_EPCs_Human0.85076321
124CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.85036790
125* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.84936565
126FOXP3_21729870_ChIP-Seq_TREG_Human0.83800076
127GATA1_26923725_Chip-Seq_HPCs_Mouse0.83265337
128UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83231241
129* KDM5A_27292631_Chip-Seq_BREAST_Human0.82634289
130FOXA1_27270436_Chip-Seq_PROSTATE_Human0.82564211
131FOXA1_25329375_ChIP-Seq_VCAP_Human0.82564211
132SOX9_26525672_Chip-Seq_HEART_Mouse0.82211551
133DROSHA_22980978_ChIP-Seq_HELA_Human0.82204343
134ZFX_18555785_ChIP-Seq_MESCs_Mouse0.82047225
135KLF5_20875108_ChIP-Seq_MESCs_Mouse0.81721728
136PCGF2_27294783_Chip-Seq_ESCs_Mouse0.81660462
137GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.81535469
138SOX2_19829295_ChIP-Seq_ESCs_Human0.81362250
139NANOG_19829295_ChIP-Seq_ESCs_Human0.81362250
140PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.80780363
141NCOR_22424771_ChIP-Seq_293T_Human0.79729926
142CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.79507045

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.86896846
2MP0004859_abnormal_synaptic_plasticity4.57291634
3MP0003635_abnormal_synaptic_transmissio3.34743301
4MP0004270_analgesia3.08869462
5MP0001968_abnormal_touch/_nociception3.05161436
6MP0009745_abnormal_behavioral_response3.00177240
7MP0002736_abnormal_nociception_after2.87904220
8MP0002064_seizures2.78583371
9MP0002063_abnormal_learning/memory/cond2.77071038
10MP0001529_abnormal_vocalization2.76623985
11MP0002735_abnormal_chemical_nociception2.76377456
12MP0008058_abnormal_DNA_repair2.73475746
13MP0006276_abnormal_autonomic_nervous2.63135028
14MP0009046_muscle_twitch2.57960249
15MP0002734_abnormal_mechanical_nocicepti2.55725556
16MP0002572_abnormal_emotion/affect_behav2.53352469
17MP0002272_abnormal_nervous_system2.48344678
18MP0002822_catalepsy2.40229545
19MP0003718_maternal_effect2.29081363
20MP0005423_abnormal_somatic_nervous2.18887786
21MP0001970_abnormal_pain_threshold2.06568771
22MP0001905_abnormal_dopamine_level2.02356755
23MP0001440_abnormal_grooming_behavior1.99532692
24MP0001486_abnormal_startle_reflex1.99248347
25MP0002733_abnormal_thermal_nociception1.98502290
26MP0001501_abnormal_sleep_pattern1.98078070
27MP0002184_abnormal_innervation1.91921489
28MP0002067_abnormal_sensory_capabilities1.88363959
29MP0003693_abnormal_embryo_hatching1.87534891
30MP0000778_abnormal_nervous_system1.87455359
31MP0008877_abnormal_DNA_methylation1.79320363
32MP0004924_abnormal_behavior1.76644904
33MP0005386_behavior/neurological_phenoty1.76644904
34MP0001188_hyperpigmentation1.76601373
35MP0003122_maternal_imprinting1.75044250
36MP0004142_abnormal_muscle_tone1.67687803
37MP0002163_abnormal_gland_morphology1.62505550
38MP0002557_abnormal_social/conspecific_i1.54708743
39MP0003123_paternal_imprinting1.54178449
40MP0000955_abnormal_spinal_cord1.53057699
41MP0001984_abnormal_olfaction1.53021709
42MP0003787_abnormal_imprinting1.52448818
43MP0004811_abnormal_neuron_physiology1.51869772
44MP0002234_abnormal_pharynx_morphology1.50303922
45MP0001293_anophthalmia1.48263546
46MP0003186_abnormal_redox_activity1.47077160
47MP0003890_abnormal_embryonic-extraembry1.43708196
48MP0005646_abnormal_pituitary_gland1.40574735
49MP0003011_delayed_dark_adaptation1.37549044
50MP0003879_abnormal_hair_cell1.36281187
51MP0002938_white_spotting1.33510463
52MP0001664_abnormal_digestion1.32535674
53MP0002066_abnormal_motor_capabilities/c1.31962520
54MP0002882_abnormal_neuron_morphology1.31728134
55MP0010386_abnormal_urinary_bladder1.30896713
56MP0010094_abnormal_chromosome_stability1.29598486
57MP0002210_abnormal_sex_determination1.29337106
58MP0008872_abnormal_physiological_respon1.29200496
59MP0008932_abnormal_embryonic_tissue1.27740286
60MP0002090_abnormal_vision1.27584904
61MP0006292_abnormal_olfactory_placode1.25943868
62MP0010030_abnormal_orbit_morphology1.24573782
63MP0003329_amyloid_beta_deposits1.23416068
64MP0000372_irregular_coat_pigmentation1.21577347
65MP0008569_lethality_at_weaning1.21316235
66MP0004957_abnormal_blastocyst_morpholog1.19812304
67MP0009379_abnormal_foot_pigmentation1.19524689
68MP0001929_abnormal_gametogenesis1.18870257
69MP0005499_abnormal_olfactory_system1.16637144
70MP0005394_taste/olfaction_phenotype1.16637144
71MP0006035_abnormal_mitochondrial_morpho1.15327328
72MP0002638_abnormal_pupillary_reflex1.14906041
73MP0005379_endocrine/exocrine_gland_phen1.14520073
74MP0003119_abnormal_digestive_system1.14511130
75MP0006036_abnormal_mitochondrial_physio1.14312087
76MP0005253_abnormal_eye_physiology1.13731067
77MP0003786_premature_aging1.12839674
78MP0005084_abnormal_gallbladder_morpholo1.10792199
79MP0003567_abnormal_fetal_cardiomyocyte1.10672702
80MP0003121_genomic_imprinting1.09577440
81MP0002152_abnormal_brain_morphology1.06325997
82MP0005083_abnormal_biliary_tract1.05927672
83MP0002233_abnormal_nose_morphology1.05130629
84MP0001485_abnormal_pinna_reflex1.03468127
85MP0006072_abnormal_retinal_apoptosis1.02759929
86MP0005645_abnormal_hypothalamus_physiol1.02270467
87MP0004145_abnormal_muscle_electrophysio1.00049967
88MP0000653_abnormal_sex_gland1.00048032
89MP0001502_abnormal_circadian_rhythm0.99927539
90MP0003806_abnormal_nucleotide_metabolis0.99047913
91MP0000751_myopathy0.98464573
92MP0000049_abnormal_middle_ear0.98079115
93MP0000631_abnormal_neuroendocrine_gland0.97594130
94MP0001145_abnormal_male_reproductive0.97129981
95MP0004133_heterotaxia0.95832491
96MP0002229_neurodegeneration0.95140851
97MP0002876_abnormal_thyroid_physiology0.93028266
98MP0002752_abnormal_somatic_nervous0.93016497
99MP0008789_abnormal_olfactory_epithelium0.91982812
100MP0003941_abnormal_skin_development0.89055519
101MP0002069_abnormal_eating/drinking_beha0.88998469
102MP0008995_early_reproductive_senescence0.88804392
103MP0004742_abnormal_vestibular_system0.88572287
104MP0005551_abnormal_eye_electrophysiolog0.87136234
105MP0002837_dystrophic_cardiac_calcinosis0.84874387
106MP0001963_abnormal_hearing_physiology0.84767914
107MP0002102_abnormal_ear_morphology0.83362170
108MP0001666_abnormal_nutrient_absorption0.83230235
109MP0000358_abnormal_cell_content/0.83052259
110MP0002909_abnormal_adrenal_gland0.82984708
111MP0003111_abnormal_nucleus_morphology0.82433607
112MP0003938_abnormal_ear_development0.82096022
113MP0004858_abnormal_nervous_system0.81193243
114MP0004233_abnormal_muscle_weight0.79518503
115MP0000566_synostosis0.79223059
116MP0002653_abnormal_ependyma_morphology0.79204895
117MP0003646_muscle_fatigue0.79171174
118MP0005220_abnormal_exocrine_pancreas0.77994980
119MP0003631_nervous_system_phenotype0.77115637
120MP0005410_abnormal_fertilization0.75872824
121MP0003698_abnormal_male_reproductive0.75464626
122MP0005535_abnormal_body_temperature0.74055717
123MP0002751_abnormal_autonomic_nervous0.71221465
124MP0005409_darkened_coat_color0.71141542
125MP0001986_abnormal_taste_sensitivity0.69944309
126MP0003633_abnormal_nervous_system0.69195659
127MP0003861_abnormal_nervous_system0.68563637
128MP0003632_abnormal_nervous_system0.67316534
129MP0002160_abnormal_reproductive_system0.65298717
130MP0004215_abnormal_myocardial_fiber0.62793912
131MP0004147_increased_porphyrin_level0.62569288
132MP0004085_abnormal_heartbeat0.62484286
133MP0000026_abnormal_inner_ear0.60320675
134MP0003956_abnormal_body_size0.58819771
135MP0003634_abnormal_glial_cell0.56410431

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.14889555
2Focal motor seizures (HP:0011153)5.09830837
3Acute necrotizing encephalopathy (HP:0006965)4.72704534
4Abnormal mitochondria in muscle tissue (HP:0008316)4.47310053
5Mitochondrial inheritance (HP:0001427)4.08419592
6Progressive macrocephaly (HP:0004481)3.96585797
7Epileptic encephalopathy (HP:0200134)3.88144997
8Acute encephalopathy (HP:0006846)3.82113793
9Atonic seizures (HP:0010819)3.69560241
10Visual hallucinations (HP:0002367)3.60231585
11Hepatocellular necrosis (HP:0001404)3.58536410
12Abnormality of glycolysis (HP:0004366)3.55873094
13Increased serum pyruvate (HP:0003542)3.55873094
14Focal seizures (HP:0007359)3.50080161
15Increased CSF lactate (HP:0002490)3.48307264
16Febrile seizures (HP:0002373)3.09586219
17Hyperventilation (HP:0002883)3.03531571
18Progressive cerebellar ataxia (HP:0002073)2.91117638
19Delusions (HP:0000746)2.89614483
20Colon cancer (HP:0003003)2.84473224
21Absence seizures (HP:0002121)2.74183668
22Hyperglycinemia (HP:0002154)2.74179919
23Molar tooth sign on MRI (HP:0002419)2.70834318
24Abnormality of midbrain morphology (HP:0002418)2.70834318
25Limb dystonia (HP:0002451)2.70100722
26Generalized aminoaciduria (HP:0002909)2.66759383
27Hepatic necrosis (HP:0002605)2.66239554
28Cerebral hypomyelination (HP:0006808)2.65660724
29Pheochromocytoma (HP:0002666)2.64998308
30Poor suck (HP:0002033)2.63528116
31Neuroendocrine neoplasm (HP:0100634)2.63126679
32Broad-based gait (HP:0002136)2.61408569
33Decreased activity of mitochondrial respiratory chain (HP:0008972)2.58869729
34Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.58869729
35Dialeptic seizures (HP:0011146)2.58763562
36Generalized tonic-clonic seizures (HP:0002069)2.57898401
37Increased hepatocellular lipid droplets (HP:0006565)2.56636890
38Gait imbalance (HP:0002141)2.56517314
39Exercise intolerance (HP:0003546)2.53391849
40Emotional lability (HP:0000712)2.50431060
41Methylmalonic acidemia (HP:0002912)2.50132406
42Lactic acidosis (HP:0003128)2.47989598
43Leukodystrophy (HP:0002415)2.43861570
44Medial flaring of the eyebrow (HP:0010747)2.43261389
45Optic disc pallor (HP:0000543)2.41186301
46Increased serum lactate (HP:0002151)2.40886892
47Gaze-evoked nystagmus (HP:0000640)2.39623212
48Epileptiform EEG discharges (HP:0011182)2.38398773
493-Methylglutaconic aciduria (HP:0003535)2.37761588
50Abnormality of the labia minora (HP:0012880)2.35721954
51Methylmalonic aciduria (HP:0012120)2.35446763
52Poor eye contact (HP:0000817)2.31990422
53Congenital primary aphakia (HP:0007707)2.30695683
54Progressive inability to walk (HP:0002505)2.29432461
55Anxiety (HP:0000739)2.26833565
56Septo-optic dysplasia (HP:0100842)2.26680292
57Hypothermia (HP:0002045)2.26328948
58EEG with generalized epileptiform discharges (HP:0011198)2.26199896
59Respiratory failure (HP:0002878)2.26118173
60Amblyopia (HP:0000646)2.25988580
61Reticulocytopenia (HP:0001896)2.25512074
62Truncal ataxia (HP:0002078)2.24042635
63Cerebral edema (HP:0002181)2.19675893
64Increased intramyocellular lipid droplets (HP:0012240)2.18651344
65Degeneration of anterior horn cells (HP:0002398)2.17575152
66Abnormality of the anterior horn cell (HP:0006802)2.17575152
67Hypoglycemic coma (HP:0001325)2.17429456
68Unsteady gait (HP:0002317)2.17112337
69Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.16301791
70Hypoplasia of the pons (HP:0012110)2.16173942
71Hypsarrhythmia (HP:0002521)2.16162116
72Postnatal microcephaly (HP:0005484)2.15033694
73Pancreatic cysts (HP:0001737)2.14855073
74Nephrogenic diabetes insipidus (HP:0009806)2.14615908
75Abnormal hair whorl (HP:0010721)2.14425664
76Pancreatic fibrosis (HP:0100732)2.12509609
77Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.12475993
78Ankle clonus (HP:0011448)2.10549186
79Abnormality of the pons (HP:0007361)2.10507943
80True hermaphroditism (HP:0010459)2.08246345
81Impaired vibration sensation in the lower limbs (HP:0002166)2.06711777
82Cortical visual impairment (HP:0100704)2.06231208
83Lipid accumulation in hepatocytes (HP:0006561)2.03860200
84Polyphagia (HP:0002591)2.01442433
85Abnormal eating behavior (HP:0100738)2.01142441
86Lethargy (HP:0001254)2.01064414
87Renal Fanconi syndrome (HP:0001994)2.00228842
88Sensory axonal neuropathy (HP:0003390)1.99844397
89Protruding tongue (HP:0010808)1.99530263
90Abnormal protein glycosylation (HP:0012346)1.98039929
91Abnormal glycosylation (HP:0012345)1.98039929
92Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.98039929
93Abnormal protein N-linked glycosylation (HP:0012347)1.98039929
94Inability to walk (HP:0002540)1.98034164
95Type I transferrin isoform profile (HP:0003642)1.96972510
96CNS hypomyelination (HP:0003429)1.95158760
97Abnormal number of erythroid precursors (HP:0012131)1.94975765
98Stenosis of the external auditory canal (HP:0000402)1.93552627
99Muscular hypotonia of the trunk (HP:0008936)1.91841869
100Genital tract atresia (HP:0001827)1.91819538
101Hyperinsulinemic hypoglycemia (HP:0000825)1.91754827
102Failure to thrive in infancy (HP:0001531)1.91326984
103Depression (HP:0000716)1.90899383
104Nephronophthisis (HP:0000090)1.87491763
105Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.86700189
106Abnormality of alanine metabolism (HP:0010916)1.86700189
107Hyperalaninemia (HP:0003348)1.86700189
108Short chin (HP:0000331)1.86028773
109Type II lissencephaly (HP:0007260)1.84210642
110Increased muscle lipid content (HP:0009058)1.84110749
111Vaginal atresia (HP:0000148)1.83877745
112Atrophy/Degeneration involving motor neurons (HP:0007373)1.82707149
113X-linked dominant inheritance (HP:0001423)1.82361611
114Bifid tongue (HP:0010297)1.82229067
115Impaired social interactions (HP:0000735)1.82106987
116Abnormal social behavior (HP:0012433)1.82106987
117Sclerocornea (HP:0000647)1.81186787
118Type 2 muscle fiber atrophy (HP:0003554)1.81112917
119Intestinal atresia (HP:0011100)1.80696136
120Dysmetria (HP:0001310)1.80359873
121Abnormality of glycine metabolism (HP:0010895)1.80218113
122Abnormality of serine family amino acid metabolism (HP:0010894)1.80218113
123Glycosuria (HP:0003076)1.79699580
124Abnormality of urine glucose concentration (HP:0011016)1.79699580
125CNS demyelination (HP:0007305)1.78853376
126Anophthalmia (HP:0000528)1.78268029
127Short tibia (HP:0005736)1.76307566
128Optic nerve hypoplasia (HP:0000609)1.76089602
129Ependymoma (HP:0002888)1.76000070
130Aplasia/Hypoplasia of the brainstem (HP:0007362)1.74587857
131Hypoplasia of the brainstem (HP:0002365)1.74587857
132Abnormality of the lower motor neuron (HP:0002366)1.74114196
133Esotropia (HP:0000565)1.73236163
134Abnormality of the corticospinal tract (HP:0002492)1.72486596
135Specific learning disability (HP:0001328)1.72436542
136Abnormality of serum amino acid levels (HP:0003112)1.72094215
137Supernumerary spleens (HP:0009799)1.72045282
138Amyotrophic lateral sclerosis (HP:0007354)1.71996766
139Microvesicular hepatic steatosis (HP:0001414)1.71933183
140Macrocytic anemia (HP:0001972)1.71735907
141Ragged-red muscle fibers (HP:0003200)1.70930287
142Abnormality of cells of the erythroid lineage (HP:0012130)1.70839821
143Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.70012008
144Hyperglycinuria (HP:0003108)1.67757605
145Adrenal hypoplasia (HP:0000835)1.67424902
146Exertional dyspnea (HP:0002875)1.65444333
147Absent septum pellucidum (HP:0001331)1.65429591
148Narrow forehead (HP:0000341)1.65120783
149Hypoplastic pelvis (HP:0008839)1.63405008
150Abnormal lung lobation (HP:0002101)1.62260973
151Ketoacidosis (HP:0001993)1.62018806
152Decreased testicular size (HP:0008734)1.61683588
153Growth hormone deficiency (HP:0000824)1.60804738

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.66729799
2MAP3K123.63382150
3EPHA43.32968460
4MAP3K43.32086982
5NTRK33.22967695
6MAP2K73.18685125
7TRIM283.12718610
8STK162.66550571
9VRK22.53402035
10CDK192.48164377
11MAP3K92.44465271
12WNK32.42459792
13MAP4K22.40323712
14MARK12.26423059
15MINK12.12710664
16NME12.11227940
17ZAK2.09197945
18DAPK12.06258454
19MST42.04924544
20MAP2K41.99512586
21DAPK21.84792698
22ARAF1.79310609
23MAPK131.77178881
24GRK51.74511804
25BUB11.72891827
26PLK21.66888063
27TNIK1.64049914
28PBK1.62822349
29NUAK11.59054890
30TSSK61.57519245
31PNCK1.53498857
32CCNB11.45473071
33CSNK1G11.45347153
34TTK1.39848667
35UHMK11.37323318
36EIF2AK31.32711581
37OXSR11.28609213
38BRAF1.27006819
39TESK11.26675705
40CSNK1A1L1.24596642
41PLK11.23963242
42PAK31.20758772
43RIPK41.19455369
44CDK51.15307558
45PLK41.15293268
46CDK181.14024379
47INSRR1.09607857
48CDK141.08158698
49NME21.08004207
50CDK151.07422272
51BCR1.06581409
52NTRK21.06499339
53STK391.06256787
54PRKCG1.04493520
55PRPF4B1.03072424
56CAMKK21.02245588
57STK38L1.01485602
58CDK11A1.00574391
59NTRK11.00157200
60DYRK20.98490849
61BCKDK0.96550658
62CAMK2A0.96360011
63SRPK10.92819281
64CAMK2B0.92207128
65TLK10.91797941
66MAP3K60.91753456
67SIK30.89784991
68AKT30.89130188
69PIK3CA0.87425756
70DYRK1A0.86698986
71DYRK30.86392967
72GRK10.86246719
73MAPKAPK50.85800737
74PRKCI0.85420512
75LIMK10.85083527
76MKNK20.84064876
77KSR10.83694737
78FRK0.83026372
79CSNK1G20.81646002
80PDK20.80130561
81SCYL20.79792618
82VRK10.79532942
83PAK60.77645756
84ERBB30.76070671
85FES0.75100295
86BMPR1B0.73731997
87MKNK10.73625198
88CAMKK10.73319957
89KSR20.72743776
90PDK40.72626027
91PDK30.72626027
92ADRBK20.71315092
93TIE10.67955320
94CSNK1G30.66988326
95PASK0.63583615
96PTK2B0.63389365
97BMPR20.62663963
98PLK30.61618909
99GRK70.59619076
100WNK40.59333279
101EIF2AK10.58260364
102AURKA0.55611684
103TESK20.55297487
104MYLK0.55250812
105FGR0.54977383
106CSNK2A10.54332081
107SGK4940.54064568
108SGK2230.54064568
109CSNK2A20.53653157
110CHEK20.53287753
111RAF10.52955668
112MAPKAPK30.51977428
113TAF10.50919318
114ADRBK10.49440713
115AURKB0.49088170
116MAP2K10.48854167
117CSNK1E0.47909515
118DAPK30.47888457
119NEK10.47570530
120OBSCN0.47340580
121SIK20.47198231
122WEE10.46821251
123CSNK1A10.45358492
124EPHB20.45313783
125ATR0.45195721
126BRSK10.43847340
127ATM0.41780404
128PHKG10.40887251
129PHKG20.40887251
130ABL20.40785814
131CAMK2G0.40716933
132MUSK0.40306805
133CDC70.38737296
134CAMK2D0.38679607
135LATS20.37644961
136PINK10.36795644
137CDK80.36722550
138ACVR1B0.34135007
139PRKCE0.33951263
140PRKACA0.33505865
141MAP2K60.32285847
142PRKD30.31180258
143ROCK20.30731300
144GRK60.30139133

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.90920234
2Nicotine addiction_Homo sapiens_hsa050333.40360992
3Parkinsons disease_Homo sapiens_hsa050123.36604885
4Synaptic vesicle cycle_Homo sapiens_hsa047213.24059843
5Alzheimers disease_Homo sapiens_hsa050102.64946619
6Collecting duct acid secretion_Homo sapiens_hsa049662.63141194
7Huntingtons disease_Homo sapiens_hsa050162.44983933
8Proteasome_Homo sapiens_hsa030502.35196466
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.32083828
10Long-term potentiation_Homo sapiens_hsa047202.14714416
11Fatty acid elongation_Homo sapiens_hsa000622.14685030
12GABAergic synapse_Homo sapiens_hsa047272.13011522
13Amphetamine addiction_Homo sapiens_hsa050312.12214038
14Pancreatic secretion_Homo sapiens_hsa049722.12053739
15Vibrio cholerae infection_Homo sapiens_hsa051102.05523788
16Protein export_Homo sapiens_hsa030601.98207257
17Morphine addiction_Homo sapiens_hsa050321.92094173
18Olfactory transduction_Homo sapiens_hsa047401.88937328
19Circadian entrainment_Homo sapiens_hsa047131.87775773
20Dopaminergic synapse_Homo sapiens_hsa047281.87550606
21Non-homologous end-joining_Homo sapiens_hsa034501.82407818
22Cardiac muscle contraction_Homo sapiens_hsa042601.78397644
23Glutamatergic synapse_Homo sapiens_hsa047241.78181418
24Propanoate metabolism_Homo sapiens_hsa006401.77224739
25Taste transduction_Homo sapiens_hsa047421.70754908
26Ribosome_Homo sapiens_hsa030101.68665395
27Steroid biosynthesis_Homo sapiens_hsa001001.66789624
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.65277763
29RNA polymerase_Homo sapiens_hsa030201.61605858
30Serotonergic synapse_Homo sapiens_hsa047261.60859382
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.59339615
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49086293
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.48165261
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.47220785
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.46742962
36RNA degradation_Homo sapiens_hsa030181.45299826
37Fanconi anemia pathway_Homo sapiens_hsa034601.44623253
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.42767002
39Salivary secretion_Homo sapiens_hsa049701.36458651
40Insulin secretion_Homo sapiens_hsa049111.34864160
41Long-term depression_Homo sapiens_hsa047301.34115669
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.32610324
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28510735
44Calcium signaling pathway_Homo sapiens_hsa040201.28390447
45Cholinergic synapse_Homo sapiens_hsa047251.24485002
46Butanoate metabolism_Homo sapiens_hsa006501.24100217
47Folate biosynthesis_Homo sapiens_hsa007901.23826582
48Oocyte meiosis_Homo sapiens_hsa041141.23576132
49Cocaine addiction_Homo sapiens_hsa050301.13070613
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.11195077
51Gastric acid secretion_Homo sapiens_hsa049711.09239377
52Sulfur relay system_Homo sapiens_hsa041221.07313385
53Selenocompound metabolism_Homo sapiens_hsa004501.07290721
54Renin secretion_Homo sapiens_hsa049241.04618603
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.98908939
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95848148
57Phototransduction_Homo sapiens_hsa047440.95164764
58Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95025158
59Oxytocin signaling pathway_Homo sapiens_hsa049210.94210762
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93359007
61Gap junction_Homo sapiens_hsa045400.93294144
62One carbon pool by folate_Homo sapiens_hsa006700.91032789
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.91026869
64Peroxisome_Homo sapiens_hsa041460.90598716
65Vitamin B6 metabolism_Homo sapiens_hsa007500.90330420
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.90151017
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89859349
68Carbon metabolism_Homo sapiens_hsa012000.89312675
69Glutathione metabolism_Homo sapiens_hsa004800.86718734
70GnRH signaling pathway_Homo sapiens_hsa049120.86087745
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82973062
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78250220
73Arginine and proline metabolism_Homo sapiens_hsa003300.75453192
74Pyruvate metabolism_Homo sapiens_hsa006200.74096986
75Regulation of autophagy_Homo sapiens_hsa041400.73948423
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71042695
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69411400
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68904233
79Fatty acid metabolism_Homo sapiens_hsa012120.67872031
80Sulfur metabolism_Homo sapiens_hsa009200.67239855
81Purine metabolism_Homo sapiens_hsa002300.67013750
82Cell cycle_Homo sapiens_hsa041100.63989190
83Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63443659
84Alcoholism_Homo sapiens_hsa050340.63244004
85Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61576527
86beta-Alanine metabolism_Homo sapiens_hsa004100.60636508
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60561837
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.60183452
89Spliceosome_Homo sapiens_hsa030400.59909461
90Pyrimidine metabolism_Homo sapiens_hsa002400.58939256
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56865565
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56722583
93cAMP signaling pathway_Homo sapiens_hsa040240.56216581
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54909584
952-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53430683
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53413694
97Axon guidance_Homo sapiens_hsa043600.53005844
98Basal transcription factors_Homo sapiens_hsa030220.52584197
99Melanogenesis_Homo sapiens_hsa049160.51733733
100RNA transport_Homo sapiens_hsa030130.51533014
101Caffeine metabolism_Homo sapiens_hsa002320.50142818
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48212589
103Cysteine and methionine metabolism_Homo sapiens_hsa002700.48155074
104Mismatch repair_Homo sapiens_hsa034300.47129186
105Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45575108
106ErbB signaling pathway_Homo sapiens_hsa040120.45336508
107Estrogen signaling pathway_Homo sapiens_hsa049150.44246525
108Tryptophan metabolism_Homo sapiens_hsa003800.44172318
109DNA replication_Homo sapiens_hsa030300.43880118
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.42898653
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42112255
112Protein digestion and absorption_Homo sapiens_hsa049740.41360347
113Nucleotide excision repair_Homo sapiens_hsa034200.41014493
114Homologous recombination_Homo sapiens_hsa034400.40277300
115Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39107311
116N-Glycan biosynthesis_Homo sapiens_hsa005100.36345910
117Fatty acid degradation_Homo sapiens_hsa000710.34829339
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34772305
119Primary bile acid biosynthesis_Homo sapiens_hsa001200.33768410
120Metabolic pathways_Homo sapiens_hsa011000.33349776
121Phagosome_Homo sapiens_hsa041450.32915919
122mRNA surveillance pathway_Homo sapiens_hsa030150.32169966
123Fat digestion and absorption_Homo sapiens_hsa049750.32034515
124Rheumatoid arthritis_Homo sapiens_hsa053230.31859968
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31799820
126Type I diabetes mellitus_Homo sapiens_hsa049400.31757516
127Glioma_Homo sapiens_hsa052140.30958640
128Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.30656842
129Biosynthesis of amino acids_Homo sapiens_hsa012300.30204424
130cGMP-PKG signaling pathway_Homo sapiens_hsa040220.29196954
131Circadian rhythm_Homo sapiens_hsa047100.28160510
132Thyroid hormone synthesis_Homo sapiens_hsa049180.27894167
133Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27653787
134Hedgehog signaling pathway_Homo sapiens_hsa043400.26847662
135Ether lipid metabolism_Homo sapiens_hsa005650.26580149
136p53 signaling pathway_Homo sapiens_hsa041150.25845882
137Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.24972076
138Drug metabolism - other enzymes_Homo sapiens_hsa009830.23862254
139Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.23653525
140Base excision repair_Homo sapiens_hsa034100.22840581
141VEGF signaling pathway_Homo sapiens_hsa043700.22181664
142Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21478569
143Glycerolipid metabolism_Homo sapiens_hsa005610.20522361
144MAPK signaling pathway_Homo sapiens_hsa040100.20083278

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