LCMT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this intronless gene belongs to the highly variable methyltransferase superfamily. This gene is the inferred homolog of the Saccharomyces cerevisiae carboxymethyltransferase gene PPM2 that is essential for the synthesis of the hypermodified guanosine Wybutosine (yW). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of DNA endoreduplication (GO:0032875)8.01365159
2behavioral response to nicotine (GO:0035095)6.64447545
3membrane depolarization during cardiac muscle cell action potential (GO:0086012)6.16416247
4membrane repolarization during cardiac muscle cell action potential (GO:0086013)5.62922904
5ribosomal small subunit assembly (GO:0000028)5.36008992
6membrane repolarization during action potential (GO:0086011)5.28942000
7mesenchymal cell differentiation involved in kidney development (GO:0072161)5.26778735
8mesenchymal cell differentiation involved in renal system development (GO:2001012)5.26778735
9mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)5.26011943
10parturition (GO:0007567)4.87413740
11DNA deamination (GO:0045006)4.79135844
12negative regulation of macrophage differentiation (GO:0045650)4.73922361
13protein polyglutamylation (GO:0018095)4.54714054
14gamma-aminobutyric acid transport (GO:0015812)4.49336170
15negative regulation of DNA-dependent DNA replication (GO:2000104)4.47650397
16viral transcription (GO:0019083)4.28309406
17SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.22165907
18translational termination (GO:0006415)4.21479878
19cotranslational protein targeting to membrane (GO:0006613)4.11172865
20negative regulation of response to food (GO:0032096)4.10598045
21negative regulation of appetite (GO:0032099)4.10598045
22cell proliferation in forebrain (GO:0021846)4.10121497
23protein targeting to ER (GO:0045047)4.09734946
24maturation of SSU-rRNA (GO:0030490)4.08094036
25DNA strand elongation involved in DNA replication (GO:0006271)4.01232744
26positive regulation of potassium ion transmembrane transport (GO:1901381)3.99641321
27positive regulation of synapse maturation (GO:0090129)3.98942558
28cellular potassium ion homeostasis (GO:0030007)3.95692401
29membrane repolarization (GO:0086009)3.94392208
30protein localization to endoplasmic reticulum (GO:0070972)3.90991063
31establishment of protein localization to endoplasmic reticulum (GO:0072599)3.90887464
32nucleobase biosynthetic process (GO:0046112)3.90649115
33deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.90189620
34magnesium ion transport (GO:0015693)3.89772711
35antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.85660958
36antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.85660958
37translational elongation (GO:0006414)3.79330611
38DNA strand elongation (GO:0022616)3.78716897
39regulation of membrane repolarization (GO:0060306)3.77399296
40mesenchymal to epithelial transition (GO:0060231)3.75708506
41regulation of skeletal muscle contraction (GO:0014819)3.74333202
42nonmotile primary cilium assembly (GO:0035058)3.71455332
43ribosomal small subunit biogenesis (GO:0042274)3.68346601
44DNA replication initiation (GO:0006270)3.68110022
45serotonin metabolic process (GO:0042428)3.62972132
46purine-containing compound salvage (GO:0043101)3.62215342
47DNA unwinding involved in DNA replication (GO:0006268)3.60532442
48folic acid-containing compound biosynthetic process (GO:0009396)3.59077383
49formation of translation preinitiation complex (GO:0001731)3.58766219
50negative regulation of granulocyte differentiation (GO:0030853)3.57678678
51translational initiation (GO:0006413)3.53941166
52regulation of synapse maturation (GO:0090128)3.48554497
53telomere maintenance via semi-conservative replication (GO:0032201)3.48517394
54primary amino compound metabolic process (GO:1901160)3.47598596
55regulation of potassium ion transmembrane transport (GO:1901379)3.43777099
56mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.43347635
57mitochondrial respiratory chain complex I assembly (GO:0032981)3.43347635
58NADH dehydrogenase complex assembly (GO:0010257)3.43347635
59regulation of mesoderm development (GO:2000380)3.39400424
60L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.39145054
61cellular response to electrical stimulus (GO:0071257)3.37761495
62purine nucleobase biosynthetic process (GO:0009113)3.36077300
63pteridine-containing compound biosynthetic process (GO:0042559)3.34489472
64viral life cycle (GO:0019058)3.33557217
65nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.30814584
66cellular anion homeostasis (GO:0030002)3.29930313
67protein complex biogenesis (GO:0070271)3.28293177
68regulation of response to food (GO:0032095)3.23359925
69sulfation (GO:0051923)3.23322447
70regulation of female receptivity (GO:0045924)3.21868825
71synaptic transmission, cholinergic (GO:0007271)3.21506779
72water-soluble vitamin biosynthetic process (GO:0042364)3.20846839
73signal peptide processing (GO:0006465)3.20153574
74cellular response to exogenous dsRNA (GO:0071360)3.19825778
75cellular protein complex disassembly (GO:0043624)3.15402314
76tRNA methylation (GO:0030488)3.13038745
77regulation of hydrogen peroxide metabolic process (GO:0010310)3.13024290
78antigen processing and presentation of endogenous antigen (GO:0019883)3.12264149
79ovulation cycle (GO:0042698)3.10383039
80translation (GO:0006412)3.10119704
81startle response (GO:0001964)3.09818038
82regulation of mesonephros development (GO:0061217)3.07127029
83ribosomal large subunit biogenesis (GO:0042273)3.06468686
84Golgi transport vesicle coating (GO:0048200)3.02549146
85COPI coating of Golgi vesicle (GO:0048205)3.02549146
86protein localization to synapse (GO:0035418)3.01517625
87potassium ion import (GO:0010107)2.98178145
88antigen processing and presentation via MHC class Ib (GO:0002475)2.95509335
89negative regulation of systemic arterial blood pressure (GO:0003085)2.94467806
90DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.94462250
91membrane depolarization during action potential (GO:0086010)2.93910569
92mitochondrial respiratory chain complex assembly (GO:0033108)2.93448274
93somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.91829866
94isotype switching (GO:0045190)2.91829866
95somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.91829866
96telomere maintenance via recombination (GO:0000722)2.91716447
97vitamin catabolic process (GO:0009111)2.91490574
98fat-soluble vitamin catabolic process (GO:0042363)2.91490574
99GDP-mannose metabolic process (GO:0019673)2.90923528
100pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.90796675
101regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.89457327
102termination of RNA polymerase III transcription (GO:0006386)2.88856725
103transcription elongation from RNA polymerase III promoter (GO:0006385)2.88856725
104somite development (GO:0061053)2.88687884
105pseudouridine synthesis (GO:0001522)2.88162220
106transmission of nerve impulse (GO:0019226)2.87726224
107epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.87221886
108L-methionine salvage (GO:0071267)2.86743053
109L-methionine biosynthetic process (GO:0071265)2.86743053
110amino acid salvage (GO:0043102)2.86743053
111ribonucleoprotein complex biogenesis (GO:0022613)2.85845984
112pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.85781425
113pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.85358623
114negative regulation of axon extension (GO:0030517)2.84807608
115endosome to melanosome transport (GO:0035646)2.84277152
116endosome to pigment granule transport (GO:0043485)2.84277152
117folic acid metabolic process (GO:0046655)2.83533326
118middle ear morphogenesis (GO:0042474)2.83432692
119regulation of mitochondrial translation (GO:0070129)2.82790285
120positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.82284562
121negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.81065928
122protein complex disassembly (GO:0043241)2.80397725
123mitotic recombination (GO:0006312)2.79646789
124retinal ganglion cell axon guidance (GO:0031290)2.77542126
125ionotropic glutamate receptor signaling pathway (GO:0035235)2.74624074
126cardiovascular system development (GO:0072358)2.73385059
127proteasome assembly (GO:0043248)2.72750510
128glycine metabolic process (GO:0006544)2.71531083
129neuron cell-cell adhesion (GO:0007158)2.71076147
130negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.69688845
131antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.69674883
132interkinetic nuclear migration (GO:0022027)2.67244016
133DNA damage response, signal transduction resulting in transcription (GO:0042772)2.66688912
134telomere maintenance via telomere lengthening (GO:0010833)2.66664641
135pyrimidine nucleotide catabolic process (GO:0006244)2.66635158
136regulation of potassium ion transport (GO:0043266)2.66378229
137regulation of heart rate by cardiac conduction (GO:0086091)2.66072585
138female mating behavior (GO:0060180)2.65847043
139response to electrical stimulus (GO:0051602)2.65787208
140macromolecular complex disassembly (GO:0032984)2.65628186
141somatic diversification of immune receptors via somatic mutation (GO:0002566)2.64503019
142somatic hypermutation of immunoglobulin genes (GO:0016446)2.64503019
143pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.64202546
144UMP metabolic process (GO:0046049)2.64202546
145pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.64202546
146UMP biosynthetic process (GO:0006222)2.64202546
147dendritic spine morphogenesis (GO:0060997)2.63887660
148indole-containing compound metabolic process (GO:0042430)2.63524724
149cellular metabolic compound salvage (GO:0043094)2.63277435
150protein targeting to membrane (GO:0006612)2.62696859
151rRNA processing (GO:0006364)2.61870415
152pyrimidine nucleobase catabolic process (GO:0006208)2.60897798
153synapse assembly (GO:0007416)2.59650911
154deoxyribonucleotide catabolic process (GO:0009264)2.59431986
155negative regulation of telomere maintenance (GO:0032205)2.59275519
156DNA replication checkpoint (GO:0000076)2.59241548
157axonal fasciculation (GO:0007413)2.59208329
158negative regulation of transcription regulatory region DNA binding (GO:2000678)2.58898667
159ribosome biogenesis (GO:0042254)2.58153846
160action potential (GO:0001508)2.57216831
161pentose-phosphate shunt (GO:0006098)2.56529289
162antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.55736269
163deoxyribose phosphate catabolic process (GO:0046386)2.55468153
164glutamate receptor signaling pathway (GO:0007215)2.54731966
165tRNA modification (GO:0006400)2.54617983
166epithelial cilium movement (GO:0003351)2.54082094
167behavioral defense response (GO:0002209)2.53937553
168behavioral fear response (GO:0001662)2.53937553
169multicellular organismal signaling (GO:0035637)2.53538029
170striatum development (GO:0021756)2.53447960
171regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.53071030
172regulation of potassium ion transmembrane transporter activity (GO:1901016)2.52639826
173embryonic digestive tract morphogenesis (GO:0048557)2.52562280
174substrate-independent telencephalic tangential migration (GO:0021826)2.52410644
175substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.52410644
176rRNA metabolic process (GO:0016072)2.52003070
177postsynaptic membrane organization (GO:0001941)2.51721274
178IMP biosynthetic process (GO:0006188)2.50900204
179RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.50589551
180indolalkylamine metabolic process (GO:0006586)2.50254834
181fear response (GO:0042596)2.50114996
182negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.49813312
183neuronal action potential (GO:0019228)2.49446132
184cellular component biogenesis (GO:0044085)2.48636205
185spinal cord development (GO:0021510)2.48275066
186positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.48247416
187nuclear-transcribed mRNA catabolic process (GO:0000956)2.48157441
188regulation of appetite (GO:0032098)2.48009554
189head development (GO:0060322)2.47644635
190negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.46097144
191negative regulation of RNA splicing (GO:0033119)2.45985080
192ubiquinone biosynthetic process (GO:0006744)2.45313960
193quinone biosynthetic process (GO:1901663)2.45313960
194base-excision repair, AP site formation (GO:0006285)2.45236638
195somatic recombination of immunoglobulin gene segments (GO:0016447)2.43572564
196methionine biosynthetic process (GO:0009086)2.43460989
197B cell mediated immunity (GO:0019724)2.41973573
198L-serine metabolic process (GO:0006563)2.41082867
199GMP metabolic process (GO:0046037)2.40273073

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.98029192
2E2F7_22180533_ChIP-Seq_HELA_Human5.91685148
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.87349469
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.56227059
5GBX2_23144817_ChIP-Seq_PC3_Human2.86708534
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.85388752
7* GABP_17652178_ChIP-ChIP_JURKAT_Human2.85171171
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.80263940
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.69556320
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.67509357
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.64499371
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.61678043
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.61045193
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.54781685
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.51991138
16BMI1_23680149_ChIP-Seq_NPCS_Mouse2.48410699
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.42671549
18CBX2_27304074_Chip-Seq_ESCs_Mouse2.42663728
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.38953332
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.37245378
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.37055193
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.35447591
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33609894
24REST_21632747_ChIP-Seq_MESCs_Mouse2.31597374
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.29417247
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.29006435
27CREB1_15753290_ChIP-ChIP_HEK293T_Human2.26168617
28GATA1_22025678_ChIP-Seq_K562_Human2.21968606
29MYC_19030024_ChIP-ChIP_MESCs_Mouse2.21964337
30MYC_19079543_ChIP-ChIP_MESCs_Mouse2.20507449
31IGF1R_20145208_ChIP-Seq_DFB_Human2.19631076
32IRF1_19129219_ChIP-ChIP_H3396_Human2.17200480
33EZH2_27294783_Chip-Seq_ESCs_Mouse2.16127588
34JARID2_20075857_ChIP-Seq_MESCs_Mouse2.15948186
35VDR_22108803_ChIP-Seq_LS180_Human2.13058438
36SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.11307282
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.10337085
38E2F4_17652178_ChIP-ChIP_JURKAT_Human2.10113950
39VDR_23849224_ChIP-Seq_CD4+_Human2.09568334
40XRN2_22483619_ChIP-Seq_HELA_Human2.09130340
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.07316616
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.02899135
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.02260828
44SUZ12_27294783_Chip-Seq_ESCs_Mouse2.00477355
45* RNF2_27304074_Chip-Seq_NSC_Mouse2.00176995
46RNF2_27304074_Chip-Seq_ESCs_Mouse1.97034474
47MYC_22102868_ChIP-Seq_BL_Human1.95455493
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94779667
49SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.94699520
50FOXP3_21729870_ChIP-Seq_TREG_Human1.92486538
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.89949540
52SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.89465260
53E2F1_18555785_ChIP-Seq_MESCs_Mouse1.89212009
54RNF2_18974828_ChIP-Seq_MESCs_Mouse1.88387734
55EZH2_18974828_ChIP-Seq_MESCs_Mouse1.88387734
56FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.87607850
57NELFA_20434984_ChIP-Seq_ESCs_Mouse1.86080221
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83998802
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.83831705
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81485307
61GABP_19822575_ChIP-Seq_HepG2_Human1.81121628
62SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.80844471
63ZNF274_21170338_ChIP-Seq_K562_Hela1.76901117
64DCP1A_22483619_ChIP-Seq_HELA_Human1.76571078
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.74226829
66EGR1_19374776_ChIP-ChIP_THP-1_Human1.73271366
67SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.72896045
68TAF15_26573619_Chip-Seq_HEK293_Human1.72127639
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.71990570
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.70143343
71PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.69674755
72CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.67997624
73CIITA_25753668_ChIP-Seq_RAJI_Human1.67968463
74SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.67953507
75FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.67799111
76REST_18959480_ChIP-ChIP_MESCs_Mouse1.67371967
77IRF8_22096565_ChIP-ChIP_GC-B_Human1.67228242
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.66207520
79CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65871488
80THAP11_20581084_ChIP-Seq_MESCs_Mouse1.65787850
81HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.65751116
82SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.61507262
83CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.59627566
84ZFX_18555785_ChIP-Seq_MESCs_Mouse1.58392435
85CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57864776
86EWS_26573619_Chip-Seq_HEK293_Human1.56889470
87NOTCH1_21737748_ChIP-Seq_TLL_Human1.55209706
88MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.55171730
89VDR_21846776_ChIP-Seq_THP-1_Human1.54827452
90TTF2_22483619_ChIP-Seq_HELA_Human1.54451699
91RING1B_27294783_Chip-Seq_ESCs_Mouse1.53199265
92MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.49647690
93FOXM1_23109430_ChIP-Seq_U2OS_Human1.48466636
94RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.47847548
95CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.47260030
96ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.46885748
97CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.45306736
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.45229107
99SPI1_23547873_ChIP-Seq_NB4_Human1.45119581
100IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.44778319
101MTF2_20144788_ChIP-Seq_MESCs_Mouse1.44449723
102PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43943788
103P300_19829295_ChIP-Seq_ESCs_Human1.42993114
104YY1_21170310_ChIP-Seq_MESCs_Mouse1.41005671
105PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40818149
106MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39620899
107POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38394488
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.38222324
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38222324
110* E2F1_21310950_ChIP-Seq_MCF-7_Human1.37404868
111EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37265490
112TP53_20018659_ChIP-ChIP_R1E_Mouse1.35817472
113SCL_19346495_ChIP-Seq_HPC-7_Human1.35014464
114GATA1_26923725_Chip-Seq_HPCs_Mouse1.34217335
115MYCN_18555785_ChIP-Seq_MESCs_Mouse1.33498506
116GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.30921121
117CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.30580016
118PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28901722
119* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.27976348
120ELK1_19687146_ChIP-ChIP_HELA_Human1.27799176
121NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27775338
122BCAT_22108803_ChIP-Seq_LS180_Human1.27042755
123FUS_26573619_Chip-Seq_HEK293_Human1.26577888
124SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26309264
125TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26290765
126MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25674037
127AR_21909140_ChIP-Seq_LNCAP_Human1.23445242
128TFEB_21752829_ChIP-Seq_HELA_Human1.22300848
129MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21934597
130UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21661205
131KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.21326718
132* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19408667
133POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18075552
134ER_23166858_ChIP-Seq_MCF-7_Human1.17728900
135MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17494559
136PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.17082099
137CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.16290791
138* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15353209
139KDM5A_27292631_Chip-Seq_BREAST_Human1.12630795
140ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11904422
141MAF_26560356_Chip-Seq_TH1_Human1.10909105
142TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10726569
143NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10673335
144SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10619490
145TP63_19390658_ChIP-ChIP_HaCaT_Human1.10347764
146MYB_21317192_ChIP-Seq_ERMYB_Mouse1.09945847
147TCF4_23295773_ChIP-Seq_U87_Human1.08375963
148PIAS1_25552417_ChIP-Seq_VCAP_Human1.08295803
149NCOR_22424771_ChIP-Seq_293T_Human1.08223753
150AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08038636
151ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07910242
152MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.07614846
153* SMAD4_21799915_ChIP-Seq_A2780_Human1.07414239
154* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06969584
155AR_25329375_ChIP-Seq_VCAP_Human1.06821838
156STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05670492
157GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03425967
158UTX_26944678_Chip-Seq_JUKART_Human1.03302459
159MYB_26560356_Chip-Seq_TH2_Human1.02224744
160DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01786550
161STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01744504
162GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01637985
163PPARA_22158963_ChIP-Seq_LIVER_Mouse1.01528523
164GATA3_21878914_ChIP-Seq_MCF-7_Human1.01102296
165KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00860089
166POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00815296
167CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00464716
168TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00140003
169POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00081136
170SMAD3_21741376_ChIP-Seq_EPCs_Human0.99918954
171TP53_22573176_ChIP-Seq_HFKS_Human0.98929089
172DROSHA_22980978_ChIP-Seq_HELA_Human0.98926897
173SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98835793
174STAT3_23295773_ChIP-Seq_U87_Human0.98694048
175EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98505022
176TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98063825
177RING1B_27294783_Chip-Seq_NPCs_Mouse0.97614484
178TDRD3_21172665_ChIP-Seq_MCF-7_Human0.97363450
179STAT4_19710469_ChIP-ChIP_TH1__Mouse0.96940679
180NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96654029
181MYB_26560356_Chip-Seq_TH1_Human0.96254839
182HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96111379
183YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94655198
184MAF_26560356_Chip-Seq_TH2_Human0.94361153
185CBP_20019798_ChIP-Seq_JUKART_Human0.94306846
186IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94306846
187EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94287102
188SOX2_21211035_ChIP-Seq_LN229_Gbm0.94205552
189MYC_18940864_ChIP-ChIP_HL60_Human0.93790172
190PRDM14_20953172_ChIP-Seq_ESCs_Human0.93462286
191CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93445827
192CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93196805
193JUN_21703547_ChIP-Seq_K562_Human0.92468586
194LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92073968
195RUNX1_22412390_ChIP-Seq_EML_Mouse0.91985463
196FLI1_27457419_Chip-Seq_LIVER_Mouse0.90193596
197OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89943269
198AR_19668381_ChIP-Seq_PC3_Human0.88408050
199FLI1_21867929_ChIP-Seq_TH2_Mouse0.88131462

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002160_abnormal_reproductive_system3.38129922
2MP0002396_abnormal_hematopoietic_system2.87771987
3MP0003693_abnormal_embryo_hatching2.86357935
4MP0001440_abnormal_grooming_behavior2.67955888
5MP0004885_abnormal_endolymph2.58046849
6MP0008877_abnormal_DNA_methylation2.51141197
7MP0002638_abnormal_pupillary_reflex2.50176977
8MP0010094_abnormal_chromosome_stability2.48770502
9MP0002139_abnormal_hepatobiliary_system2.41130764
10MP0003806_abnormal_nucleotide_metabolis2.35587783
11MP0005389_reproductive_system_phenotype2.35527500
12MP0006276_abnormal_autonomic_nervous2.34173145
13MP0008058_abnormal_DNA_repair2.28661292
14MP0003111_abnormal_nucleus_morphology2.28465674
15MP0005075_abnormal_melanosome_morpholog2.27666370
16MP0005646_abnormal_pituitary_gland2.25895878
17MP0004957_abnormal_blastocyst_morpholog2.19081722
18MP0004145_abnormal_muscle_electrophysio2.16538963
19MP0001485_abnormal_pinna_reflex2.15379145
20MP0002837_dystrophic_cardiac_calcinosis2.13837448
21MP0009333_abnormal_splenocyte_physiolog2.11879964
22MP0002653_abnormal_ependyma_morphology2.11785037
23MP0005671_abnormal_response_to2.11263038
24MP0005058_abnormal_lysosome_morphology2.10280422
25MP0004742_abnormal_vestibular_system2.09587820
26MP0002272_abnormal_nervous_system2.08022827
27MP0002132_abnormal_respiratory_system2.06565760
28MP0009745_abnormal_behavioral_response2.05494779
29MP0004130_abnormal_muscle_cell2.04021062
30MP0003646_muscle_fatigue1.99634819
31MP0009840_abnormal_foam_cell1.97193408
32MP0003879_abnormal_hair_cell1.96845298
33MP0001835_abnormal_antigen_presentation1.96682313
34MP0001968_abnormal_touch/_nociception1.89375931
35MP0000490_abnormal_crypts_of1.84752493
36MP0003077_abnormal_cell_cycle1.82415734
37MP0000631_abnormal_neuroendocrine_gland1.82071516
38MP0006292_abnormal_olfactory_placode1.80178410
39MP0003763_abnormal_thymus_physiology1.79197487
40MP0002733_abnormal_thermal_nociception1.77799345
41MP0009785_altered_susceptibility_to1.77635145
42MP0002064_seizures1.77333176
43MP0002398_abnormal_bone_marrow1.73732779
44MP0003635_abnormal_synaptic_transmissio1.73518949
45MP0003436_decreased_susceptibility_to1.72979425
46MP0003011_delayed_dark_adaptation1.72651763
47MP0006036_abnormal_mitochondrial_physio1.72171968
48MP0004133_heterotaxia1.71871125
49MP0003787_abnormal_imprinting1.71673524
50MP0005423_abnormal_somatic_nervous1.71207771
51MP0000685_abnormal_immune_system1.70061824
52MP0005551_abnormal_eye_electrophysiolog1.68805861
53MP0005365_abnormal_bile_salt1.67566343
54MP0002876_abnormal_thyroid_physiology1.67333752
55MP0000569_abnormal_digit_pigmentation1.63649314
56MP0001970_abnormal_pain_threshold1.62100169
57MP0003724_increased_susceptibility_to1.60010465
58MP0004270_analgesia1.59561900
59MP0004142_abnormal_muscle_tone1.58519905
60MP0003136_yellow_coat_color1.56021287
61MP0009046_muscle_twitch1.54796667
62MP0005174_abnormal_tail_pigmentation1.53882519
63MP0008007_abnormal_cellular_replicative1.53771827
64MP0002063_abnormal_learning/memory/cond1.52852661
65MP0001800_abnormal_humoral_immune1.52775800
66MP0000778_abnormal_nervous_system1.52435194
67MP0002722_abnormal_immune_system1.51040845
68MP0000689_abnormal_spleen_morphology1.51025840
69MP0002736_abnormal_nociception_after1.50769111
70MP0004147_increased_porphyrin_level1.50362792
71MP0003183_abnormal_peptide_metabolism1.49818493
72MP0005000_abnormal_immune_tolerance1.48858415
73MP0000716_abnormal_immune_system1.47725081
74MP0005025_abnormal_response_to1.47709399
75MP0002429_abnormal_blood_cell1.46528887
76MP0008872_abnormal_physiological_respon1.45817711
77MP0001486_abnormal_startle_reflex1.44348107
78MP0005360_urolithiasis1.43864853
79MP0002420_abnormal_adaptive_immunity1.43136031
80MP0002723_abnormal_immune_serum1.42723272
81MP0003942_abnormal_urinary_system1.42299536
82MP0002557_abnormal_social/conspecific_i1.42166701
83MP0001819_abnormal_immune_cell1.41126440
84MP0010386_abnormal_urinary_bladder1.39499457
85MP0002572_abnormal_emotion/affect_behav1.38168396
86MP0004859_abnormal_synaptic_plasticity1.37380268
87MP0003172_abnormal_lysosome_physiology1.37233133
88MP0006072_abnormal_retinal_apoptosis1.36917618
89MP0003880_abnormal_central_pattern1.36256162
90MP0002138_abnormal_hepatobiliary_system1.35649450
91MP0004808_abnormal_hematopoietic_stem1.34515885
92MP0002452_abnormal_antigen_presenting1.34437536
93MP0002735_abnormal_chemical_nociception1.34197856
94MP0005220_abnormal_exocrine_pancreas1.34109854
95MP0002877_abnormal_melanocyte_morpholog1.33852694
96MP0002734_abnormal_mechanical_nocicepti1.33726251
97MP0000026_abnormal_inner_ear1.33185766
98MP0005408_hypopigmentation1.32736699
99MP0002938_white_spotting1.32075711
100MP0000465_gastrointestinal_hemorrhage1.30105228
101MP0008057_abnormal_DNA_replication1.29903237
102MP0000703_abnormal_thymus_morphology1.29455073
103MP0008932_abnormal_embryonic_tissue1.29082664
104MP0006035_abnormal_mitochondrial_morpho1.26949194
105MP0001764_abnormal_homeostasis1.26353886
106MP0002067_abnormal_sensory_capabilities1.25723780
107MP0000955_abnormal_spinal_cord1.24136636
108MP0002184_abnormal_innervation1.23037476
109MP0001873_stomach_inflammation1.22755153
110MP0003186_abnormal_redox_activity1.22004538
111MP0008469_abnormal_protein_level1.20882756
112MP0002163_abnormal_gland_morphology1.20730467
113MP0005464_abnormal_platelet_physiology1.20353354
114MP0002928_abnormal_bile_duct1.20345389
115MP0006054_spinal_hemorrhage1.20222170
116MP0002019_abnormal_tumor_incidence1.19099603
117MP0001905_abnormal_dopamine_level1.18656491
118MP0001529_abnormal_vocalization1.18451164
119MP0009643_abnormal_urine_homeostasis1.18153424
120MP0001845_abnormal_inflammatory_respons1.16318837
121MP0003195_calcinosis1.14982686
122MP0001963_abnormal_hearing_physiology1.14942691
123MP0002405_respiratory_system_inflammati1.14807965
124MP0002693_abnormal_pancreas_physiology1.14667990
125MP0002095_abnormal_skin_pigmentation1.13983338
126MP0003866_abnormal_defecation1.13711213
127MP0005670_abnormal_white_adipose1.13251920
128MP0002752_abnormal_somatic_nervous1.13249506
129MP0005319_abnormal_enzyme/_coenzyme1.09594813
130MP0009379_abnormal_foot_pigmentation1.09157152
131MP0004924_abnormal_behavior1.08852153
132MP0005386_behavior/neurological_phenoty1.08852153
133MP0002419_abnormal_innate_immunity1.08731567
134MP0005636_abnormal_mineral_homeostasis1.08586018
135MP0005085_abnormal_gallbladder_physiolo1.08284005
136MP0000609_abnormal_liver_physiology1.06605211
137MP0000358_abnormal_cell_content/1.06002943
138MP0010155_abnormal_intestine_physiology1.05908099
139MP0003123_paternal_imprinting1.05586202
140MP0001188_hyperpigmentation1.04127614
141MP0001944_abnormal_pancreas_morphology1.04019161
142MP0005257_abnormal_intraocular_pressure1.03804921
143MP0000313_abnormal_cell_death1.03649634
144MP0003656_abnormal_erythrocyte_physiolo1.03044003
145MP0005195_abnormal_posterior_eye1.02627188
146MP0008789_abnormal_olfactory_epithelium1.01626273
147MP0002882_abnormal_neuron_morphology1.01422442
148MP0003191_abnormal_cellular_cholesterol1.01397548
149MP0000350_abnormal_cell_proliferation1.01186321
150MP0001293_anophthalmia1.00938232
151MP0005387_immune_system_phenotype0.99856657
152MP0001790_abnormal_immune_system0.99856657
153MP0000598_abnormal_liver_morphology0.99277926
154MP0004019_abnormal_vitamin_homeostasis0.98529212
155MP0000230_abnormal_systemic_arterial0.97970017
156MP0009053_abnormal_anal_canal0.97955364
157MP0003868_abnormal_feces_composition0.97811526
158MP0001919_abnormal_reproductive_system0.97216193
159MP0001666_abnormal_nutrient_absorption0.96969882
160MP0003890_abnormal_embryonic-extraembry0.96761721
161MP0003938_abnormal_ear_development0.95153986
162MP0005645_abnormal_hypothalamus_physiol0.94901474
163MP0002166_altered_tumor_susceptibility0.94047923
164MP0005253_abnormal_eye_physiology0.93726747
165MP0003119_abnormal_digestive_system0.93366475
166MP0000013_abnormal_adipose_tissue0.93304476
167MP0005409_darkened_coat_color0.93182430
168MP0001502_abnormal_circadian_rhythm0.91686401
169MP0001730_embryonic_growth_arrest0.90690914
170MP0002148_abnormal_hypersensitivity_rea0.89555659
171MP0000049_abnormal_middle_ear0.88993498
172MP0004043_abnormal_pH_regulation0.87785834
173MP0003943_abnormal_hepatobiliary_system0.87599835
174MP0002822_catalepsy0.87276199
175MP0001984_abnormal_olfaction0.86471318
176MP0003786_premature_aging0.85843280
177MP0000858_altered_metastatic_potential0.85644671
178MP0006082_CNS_inflammation0.84189737
179MP0008775_abnormal_heart_ventricle0.83342621
180MP0010307_abnormal_tumor_latency0.83161528
181MP0009763_increased_sensitivity_to0.79383649
182MP0003221_abnormal_cardiomyocyte_apopto0.79041472
183MP0003937_abnormal_limbs/digits/tail_de0.78609752
184MP0004085_abnormal_heartbeat0.77858566
185MP0002152_abnormal_brain_morphology0.77201718
186MP0009384_cardiac_valve_regurgitation0.76913058
187MP0002229_neurodegeneration0.76664855
188MP0009780_abnormal_chondrocyte_physiolo0.75630764
189MP0002102_abnormal_ear_morphology0.75478372
190MP0003878_abnormal_ear_physiology0.75185071
191MP0005377_hearing/vestibular/ear_phenot0.75185071
192MP0003283_abnormal_digestive_organ0.74898547
193MP0005394_taste/olfaction_phenotype0.74395134
194MP0005499_abnormal_olfactory_system0.74395134

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of midbrain morphology (HP:0002418)4.70952023
2Molar tooth sign on MRI (HP:0002419)4.70952023
3Abnormal number of erythroid precursors (HP:0012131)4.54067779
4Nephronophthisis (HP:0000090)4.49609654
5Abnormality of cells of the erythroid lineage (HP:0012130)4.29741678
6Chronic hepatic failure (HP:0100626)4.00120487
7Generalized aminoaciduria (HP:0002909)3.86736172
8Pancreatic fibrosis (HP:0100732)3.82149250
9Microvesicular hepatic steatosis (HP:0001414)3.78485799
10True hermaphroditism (HP:0010459)3.75507962
11Pancreatic cysts (HP:0001737)3.67256982
12Reduced antithrombin III activity (HP:0001976)3.64379999
13Abnormality of the renal medulla (HP:0100957)3.62898430
14Reticulocytopenia (HP:0001896)3.41945759
15Hepatic necrosis (HP:0002605)3.41371588
16Oligodontia (HP:0000677)3.30514450
17Progressive cerebellar ataxia (HP:0002073)3.27551267
18Hepatocellular necrosis (HP:0001404)3.21625850
19Aplastic anemia (HP:0001915)3.20122984
20Abnormality of T cell physiology (HP:0011840)3.18002437
21Type I transferrin isoform profile (HP:0003642)3.11281611
22Hypoglycemic coma (HP:0001325)3.10827637
23Abnormal protein glycosylation (HP:0012346)3.00675793
24Abnormal glycosylation (HP:0012345)3.00675793
25Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.00675793
26Abnormal protein N-linked glycosylation (HP:0012347)3.00675793
27Osteomalacia (HP:0002749)2.98838727
28Asplenia (HP:0001746)2.97640520
29Short femoral neck (HP:0100864)2.91607953
30Late onset (HP:0003584)2.88920677
31Petechiae (HP:0000967)2.85899271
32Aplasia/Hypoplasia of the spleen (HP:0010451)2.85118702
33Oral leukoplakia (HP:0002745)2.83970330
34Genetic anticipation (HP:0003743)2.83492374
35Medial flaring of the eyebrow (HP:0010747)2.83035493
36Pallor (HP:0000980)2.80292933
37Abnormality of the heme biosynthetic pathway (HP:0010472)2.76975987
38Macrocytic anemia (HP:0001972)2.74974657
39Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.70051074
40Decreased activity of mitochondrial respiratory chain (HP:0008972)2.70051074
41Abnormality of aromatic amino acid family metabolism (HP:0004338)2.64623845
42Elevated erythrocyte sedimentation rate (HP:0003565)2.63262578
43Congenital, generalized hypertrichosis (HP:0004540)2.62948857
44Decreased electroretinogram (ERG) amplitude (HP:0000654)2.62355685
45Abolished electroretinogram (ERG) (HP:0000550)2.62104485
46Lipid accumulation in hepatocytes (HP:0006561)2.61084417
47Abnormality of the proximal phalanges of the hand (HP:0009834)2.57920065
48Abnormality of T cells (HP:0002843)2.56250330
49Aplasia/Hypoplasia of the tibia (HP:0005772)2.55985508
50Chronic otitis media (HP:0000389)2.55889821
51Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.53765183
52Congenital stationary night blindness (HP:0007642)2.52720067
53Septo-optic dysplasia (HP:0100842)2.52696919
54Thrombocytosis (HP:0001894)2.49837039
55Furrowed tongue (HP:0000221)2.48914004
56Abnormality of DNA repair (HP:0003254)2.47941362
57Cystic liver disease (HP:0006706)2.47360429
58Abnormality of the middle phalanges of the toes (HP:0010183)2.44891888
59Increased hepatocellular lipid droplets (HP:0006565)2.43052323
60Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.42789455
61Clumsiness (HP:0002312)2.42674198
62Sclerocornea (HP:0000647)2.40523002
63Dysostosis multiplex (HP:0000943)2.40495453
64IgM deficiency (HP:0002850)2.39221538
65Short 1st metacarpal (HP:0010034)2.37850048
66Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.37850048
67Abnormality of the phalanges of the 2nd finger (HP:0009541)2.36359927
68Gait imbalance (HP:0002141)2.35920059
69Abnormality of the renal cortex (HP:0011035)2.35259768
70Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.34000343
71Pancytopenia (HP:0001876)2.31274507
72Decreased circulating renin level (HP:0003351)2.31196431
73Congenital sensorineural hearing impairment (HP:0008527)2.30995379
74Absent rod-and cone-mediated responses on ERG (HP:0007688)2.29013330
75Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.27952992
76Abnormal biliary tract physiology (HP:0012439)2.27497422
77Bile duct proliferation (HP:0001408)2.27497422
78Large eyes (HP:0001090)2.26690039
79Increased serum lactate (HP:0002151)2.25974938
80Persistence of primary teeth (HP:0006335)2.25202786
81Abnormality of dicarboxylic acid metabolism (HP:0010995)2.25156102
82Dicarboxylic aciduria (HP:0003215)2.25156102
83Hyperglycemia (HP:0003074)2.24319436
84Stenosis of the external auditory canal (HP:0000402)2.24188996
85Abnormality of monocarboxylic acid metabolism (HP:0010996)2.23118046
86Short 4th metacarpal (HP:0010044)2.22112706
87Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.22112706
88Male pseudohermaphroditism (HP:0000037)2.22080016
89Gaze-evoked nystagmus (HP:0000640)2.21456700
90Broad face (HP:0000283)2.19027812
91Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.17643794
92Aplasia/Hypoplasia of the sacrum (HP:0008517)2.17509660
93Short tibia (HP:0005736)2.16993841
94Short hallux (HP:0010109)2.15942463
95Abnormality of cochlea (HP:0000375)2.15654726
96Abnormality of the phalanges of the 5th finger (HP:0004213)2.15303213
97Thyroid-stimulating hormone excess (HP:0002925)2.14903346
98Abnormality of fatty-acid metabolism (HP:0004359)2.13295938
99Increased muscle lipid content (HP:0009058)2.13215480
100Adrenal hypoplasia (HP:0000835)2.13082149
101Ketosis (HP:0001946)2.12301842
102Increased CSF lactate (HP:0002490)2.11747667
103Insulin resistance (HP:0000855)2.11297661
104Limb dystonia (HP:0002451)2.11109865
105Drooling (HP:0002307)2.10304586
106Hypoplasia of the ulna (HP:0003022)2.09937767
107Abnormality of the anterior horn cell (HP:0006802)2.09210768
108Degeneration of anterior horn cells (HP:0002398)2.09210768
109Aplasia/Hypoplasia of the hallux (HP:0008362)2.08718861
110Hyperbilirubinemia (HP:0002904)2.08471158
111Aplasia/Hypoplasia of the patella (HP:0006498)2.08423855
112Abnormality of the renal collecting system (HP:0004742)2.08208626
113Abnormality of the 1st metacarpal (HP:0010009)2.08142573
114Anencephaly (HP:0002323)2.07918627
115Focal seizures (HP:0007359)2.07848859
116Multiple enchondromatosis (HP:0005701)2.07152960
117Hypoplasia of the uterus (HP:0000013)2.06484674
118Small hand (HP:0200055)2.05658161
119Agitation (HP:0000713)2.05384303
120Ketoacidosis (HP:0001993)2.04711192
121Bony spicule pigmentary retinopathy (HP:0007737)2.04003693
122Vacuolated lymphocytes (HP:0001922)2.03821768
123Mitochondrial inheritance (HP:0001427)2.03752298
124Congenital primary aphakia (HP:0007707)2.02723263
125Congenital hepatic fibrosis (HP:0002612)2.01211210
126Nonimmune hydrops fetalis (HP:0001790)2.00956277
127Abnormal respiratory epithelium morphology (HP:0012253)2.00064380
128Abnormal respiratory motile cilium morphology (HP:0005938)2.00064380
129Rough bone trabeculation (HP:0100670)1.99809806
130Slender long bone (HP:0003100)1.99009245
131Abnormality of the 4th metacarpal (HP:0010012)1.98899945
132Specific learning disability (HP:0001328)1.98865475
133Renal cortical cysts (HP:0000803)1.97746098
134Symphalangism affecting the phalanges of the hand (HP:0009773)1.97670251
135Epileptic encephalopathy (HP:0200134)1.97396589
136Lactic acidosis (HP:0003128)1.97032759
137Polydipsia (HP:0001959)1.96864728
138Abnormal drinking behavior (HP:0030082)1.96864728
139Increased intramyocellular lipid droplets (HP:0012240)1.96751377
140Progressive neurologic deterioration (HP:0002344)1.96566798
141Absent/shortened dynein arms (HP:0200106)1.96207866
142Dynein arm defect of respiratory motile cilia (HP:0012255)1.96207866
143Fibular aplasia (HP:0002990)1.95328735
144Megalencephaly (HP:0001355)1.94729155
145Submucous cleft hard palate (HP:0000176)1.93288159
146Abnormality of the intrinsic pathway (HP:0010989)1.92624795
147Microcytic anemia (HP:0001935)1.92611191
148Patellar aplasia (HP:0006443)1.92541208
149Prominent metopic ridge (HP:0005487)1.92161802
150Nephrogenic diabetes insipidus (HP:0009806)1.91435487
151Abnormality of the metopic suture (HP:0005556)1.91356938
152Increased neuronal autofluorescent lipopigment (HP:0002074)1.91062792
153Entropion (HP:0000621)1.91026827
154Intrahepatic cholestasis (HP:0001406)1.89604262
155Excessive salivation (HP:0003781)1.89385020
156Hypoglycemic seizures (HP:0002173)1.88454146
157Aplasia/hypoplasia of the femur (HP:0005613)1.86974512
158T lymphocytopenia (HP:0005403)1.86783609
159Abnormal delayed hypersensitivity skin test (HP:0002963)1.85608264
160Radial bowing (HP:0002986)1.85329377
161Myokymia (HP:0002411)1.85317382
162Symptomatic seizures (HP:0011145)1.85191747
163Aplasia/Hypoplasia of the fibula (HP:0006492)1.84870394
164Birth length less than 3rd percentile (HP:0003561)1.84864945
165Albinism (HP:0001022)1.84586813
166Abnormal rod and cone electroretinograms (HP:0008323)1.83689890
167Tubular atrophy (HP:0000092)1.83285134
168Recurrent abscess formation (HP:0002722)1.83180231
169Conjunctival hamartoma (HP:0100780)1.83015437
170Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.82266511
171Abnormality of alanine metabolism (HP:0010916)1.82266511
172Hyperalaninemia (HP:0003348)1.82266511
173Polyphagia (HP:0002591)1.81935874
174Exertional dyspnea (HP:0002875)1.81709370
175Absent thumb (HP:0009777)1.81646505
176Hypoplastic pelvis (HP:0008839)1.81223096
177Neutropenia (HP:0001875)1.80971166
178Recurrent viral infections (HP:0004429)1.80839418
179Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.79855864
180Abnormality of T cell number (HP:0011839)1.78268575
181Increased serum ferritin (HP:0003281)1.78180707
182Agnosia (HP:0010524)1.77860882
183Abnormality of reticulocytes (HP:0004312)1.77254599
184Purpura (HP:0000979)1.76935368
185Reduced subcutaneous adipose tissue (HP:0003758)1.76376695
186Abnormality of pyrimidine metabolism (HP:0004353)1.75398166
187Hyperlipoproteinemia (HP:0010980)1.75369223
188CNS demyelination (HP:0007305)1.72541179
189Abnormality of urine glucose concentration (HP:0011016)1.72503588
190Glycosuria (HP:0003076)1.72503588
191Hyperglycinemia (HP:0002154)1.71824058
192Hypothermia (HP:0002045)1.70131534
193Severe visual impairment (HP:0001141)1.69962698
194Proximal tubulopathy (HP:0000114)1.69343336
195Recurrent bronchitis (HP:0002837)1.68805062
196Abnormality of liposaccharide metabolism (HP:0010968)1.67410072
197Abnormality of glycosphingolipid metabolism (HP:0004343)1.67410072
198Abnormality of glycolipid metabolism (HP:0010969)1.67410072

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK25.39982964
2FRK4.94838502
3STK163.25013976
4CDK193.07572600
5EIF2AK12.92031539
6ADRBK22.77263912
7WNK42.67502375
8TESK22.66334579
9NME22.64673090
10BUB12.57820422
11PIM22.32341869
12ACVR1B2.31569452
13BCKDK2.29643103
14MAP3K92.27952847
15GRK12.22447539
16WEE12.20407341
17MAP4K12.06538563
18CDC72.02291163
19TLK11.98254255
20DYRK31.94287124
21MAP2K71.93785797
22STK391.92564497
23PINK11.87548686
24MAPK151.86709390
25MARK11.86210214
26PASK1.86022462
27TGFBR11.74913060
28KIT1.74754359
29CASK1.72101754
30ZAP701.64505446
31VRK11.61402487
32ERN11.60436711
33TXK1.59552380
34BRSK21.57669438
35NTRK31.56665758
36SCYL21.56626645
37ZAK1.56227833
38PIK3CA1.53520294
39KDR1.52864429
40CDK71.52333477
41FLT31.51963650
42TAOK31.50999352
43MST1R1.50317965
44BTK1.49634063
45TEC1.46856379
46MAPK131.44919626
47STK381.41618048
48EIF2AK31.39499120
49PLK21.37976201
50SGK21.36764266
51NTRK21.36705983
52MAP2K31.34451440
53RPS6KA21.34044374
54EEF2K1.32984256
55PRKCG1.29529189
56SGK2231.25994227
57SGK4941.25994227
58ADRBK11.23948341
59BLK1.20538441
60RPS6KB21.19323398
61RPS6KA61.18032231
62DYRK21.17459915
63INSRR1.15982000
64PAK31.13286571
65SGK31.11971542
66TNIK1.11910178
67PHKG21.11906133
68PHKG11.11906133
69SIK11.08609748
70TBK11.03681113
71MAP3K101.03133604
72MAP3K111.02839100
73DAPK21.02008776
74OXSR11.00753394
75MAP3K40.98547192
76STK110.97494844
77TYK20.94441827
78PIM10.94013204
79NEK20.93171685
80RPS6KA40.93019780
81PKN20.92919197
82ATR0.90676453
83TIE10.90169719
84TAF10.88451579
85RPS6KL10.88107744
86RPS6KC10.88107744
87CAMKK10.86774703
88MATK0.86028083
89STK40.83992196
90STK100.83720611
91CDK80.83501674
92GRK70.83221852
93PRKCI0.82674816
94TSSK60.82119138
95TESK10.81975899
96NME10.81824176
97IKBKE0.81325329
98ARAF0.81152947
99MAP3K80.80021427
100PNCK0.79948777
101SYK0.79067921
102MAPK110.78213023
103TRIB30.77681605
104CDK40.77672100
105TYRO30.76751279
106PIK3CG0.76351847
107SGK10.76177753
108NUAK10.76174096
109PRKCZ0.76165759
110IRAK30.75872285
111CSNK1G20.73696548
112PRKACA0.73569827
113NLK0.72386157
114LYN0.71578429
115MAPKAPK30.71509626
116DYRK1A0.70946909
117CCNB10.70869176
118HIPK20.70367259
119FGFR40.69929744
120AURKB0.69575486
121PAK40.69431247
122MET0.69046329
123GRK50.67962315
124SRPK10.67162675
125WNK30.65845168
126MAPKAPK50.65192887
127NEK10.63660242
128PLK40.63261254
129LCK0.62969061
130AURKA0.62707662
131CAMK2A0.62381756
132PKN10.62132500
133DYRK1B0.61538132
134PRKCE0.60621085
135PRKCH0.60613902
136IKBKB0.59779553
137GRK60.59696460
138MARK30.59356093
139MKNK20.58837481
140TGFBR20.57756592
141PLK10.57598665
142MAP2K20.56273885
143ERBB20.56227180
144NEK90.55803109
145LRRK20.54604309
146BMPR1B0.54127449
147PRKD30.53928710
148PRKCQ0.53331933
149CSF1R0.52156693
150MKNK10.51850455
151CSNK1A10.51745937
152JAK30.50548756
153PBK0.50082227
154CAMKK20.49918570
155IRAK40.49444028
156MAP2K60.48942330
157MAP3K120.48388525
158EPHA20.47845081
159RPS6KA50.47809568
160CDK50.46845687
161FGFR20.46040734
162CAMK10.44148664
163CHUK0.43443803
164CSNK1G30.43375311
165DAPK30.42223933
166TAOK20.41866870
167ABL20.40912482
168PRKACG0.40371077
169PRKCA0.39839112
170MAP2K40.38849147
171MUSK0.38697164
172BRAF0.38393925
173RPS6KA30.37341614
174MAP4K20.36619207
175PRKAA10.35959426

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.07027313
2Ribosome_Homo sapiens_hsa030103.78155889
3Nicotine addiction_Homo sapiens_hsa050333.56128277
4Mismatch repair_Homo sapiens_hsa034303.09859723
5RNA polymerase_Homo sapiens_hsa030202.91359318
6Protein export_Homo sapiens_hsa030602.79716925
7Sulfur relay system_Homo sapiens_hsa041222.69031585
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.68147071
9Proteasome_Homo sapiens_hsa030502.63851597
10Base excision repair_Homo sapiens_hsa034102.60427710
11Phototransduction_Homo sapiens_hsa047442.43862133
12Pyrimidine metabolism_Homo sapiens_hsa002402.29227239
13One carbon pool by folate_Homo sapiens_hsa006702.26818895
14Folate biosynthesis_Homo sapiens_hsa007902.23428356
15Morphine addiction_Homo sapiens_hsa050322.18104984
16Maturity onset diabetes of the young_Homo sapiens_hsa049502.16512271
17Spliceosome_Homo sapiens_hsa030402.11938715
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.11152707
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.09870503
20Homologous recombination_Homo sapiens_hsa034402.07366916
21Cardiac muscle contraction_Homo sapiens_hsa042602.02276215
22Glutamatergic synapse_Homo sapiens_hsa047242.01791174
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.90365755
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.88715841
25Nucleotide excision repair_Homo sapiens_hsa034201.82140710
26Cocaine addiction_Homo sapiens_hsa050301.79574728
27GABAergic synapse_Homo sapiens_hsa047271.77830735
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.77084604
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.76551198
30RNA transport_Homo sapiens_hsa030131.75302021
31Circadian entrainment_Homo sapiens_hsa047131.75041699
32Cholinergic synapse_Homo sapiens_hsa047251.72914696
33Pentose phosphate pathway_Homo sapiens_hsa000301.72666642
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.72121528
35Linoleic acid metabolism_Homo sapiens_hsa005911.65812768
36Serotonergic synapse_Homo sapiens_hsa047261.59532601
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.59342127
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.54701408
39Other glycan degradation_Homo sapiens_hsa005111.51712188
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.47540990
41Retinol metabolism_Homo sapiens_hsa008301.40403019
42Collecting duct acid secretion_Homo sapiens_hsa049661.39637500
43Olfactory transduction_Homo sapiens_hsa047401.38571331
44Chemical carcinogenesis_Homo sapiens_hsa052041.36638067
45Dopaminergic synapse_Homo sapiens_hsa047281.35521228
46Cell cycle_Homo sapiens_hsa041101.33117955
47Insulin secretion_Homo sapiens_hsa049111.29338332
48Taste transduction_Homo sapiens_hsa047421.27861430
49Primary immunodeficiency_Homo sapiens_hsa053401.27011929
50Steroid hormone biosynthesis_Homo sapiens_hsa001401.25796434
51Selenocompound metabolism_Homo sapiens_hsa004501.23238505
52Antigen processing and presentation_Homo sapiens_hsa046121.19737165
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19400649
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16231684
55N-Glycan biosynthesis_Homo sapiens_hsa005101.12927579
56Nitrogen metabolism_Homo sapiens_hsa009101.10519681
57Drug metabolism - other enzymes_Homo sapiens_hsa009831.10416888
58Gastric acid secretion_Homo sapiens_hsa049711.09825983
59Non-homologous end-joining_Homo sapiens_hsa034501.09629174
60Asthma_Homo sapiens_hsa053101.09495481
61Biosynthesis of amino acids_Homo sapiens_hsa012301.07778638
62Cysteine and methionine metabolism_Homo sapiens_hsa002701.07618615
63Calcium signaling pathway_Homo sapiens_hsa040201.07143623
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07111765
65p53 signaling pathway_Homo sapiens_hsa041151.06941166
66Synaptic vesicle cycle_Homo sapiens_hsa047211.06444072
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.03903262
68Legionellosis_Homo sapiens_hsa051341.01352414
69Regulation of autophagy_Homo sapiens_hsa041401.01281103
70Amphetamine addiction_Homo sapiens_hsa050311.00712081
71Parkinsons disease_Homo sapiens_hsa050121.00171251
72Carbon metabolism_Homo sapiens_hsa012000.97526716
73Herpes simplex infection_Homo sapiens_hsa051680.96830792
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96257855
75Alcoholism_Homo sapiens_hsa050340.95710299
76Thyroid cancer_Homo sapiens_hsa052160.95214400
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94455811
78Oxytocin signaling pathway_Homo sapiens_hsa049210.93380730
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92673874
80Purine metabolism_Homo sapiens_hsa002300.91922792
81Oxidative phosphorylation_Homo sapiens_hsa001900.91061672
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.87827428
83Axon guidance_Homo sapiens_hsa043600.87316034
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85479468
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.85275869
86Caffeine metabolism_Homo sapiens_hsa002320.85208268
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83812173
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.83213649
89Renin secretion_Homo sapiens_hsa049240.81533268
90Vitamin digestion and absorption_Homo sapiens_hsa049770.80547566
91Glycerolipid metabolism_Homo sapiens_hsa005610.79742014
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77656578
93Fatty acid degradation_Homo sapiens_hsa000710.77558759
94Epstein-Barr virus infection_Homo sapiens_hsa051690.77389266
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77137911
96Hedgehog signaling pathway_Homo sapiens_hsa043400.74782674
97Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74620138
98Measles_Homo sapiens_hsa051620.74453139
99Type II diabetes mellitus_Homo sapiens_hsa049300.74121336
100Fructose and mannose metabolism_Homo sapiens_hsa000510.73939062
1012-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73354890
102cAMP signaling pathway_Homo sapiens_hsa040240.73256744
103Fanconi anemia pathway_Homo sapiens_hsa034600.73141912
104Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72635241
105Acute myeloid leukemia_Homo sapiens_hsa052210.71891373
106Melanoma_Homo sapiens_hsa052180.70930636
107Salivary secretion_Homo sapiens_hsa049700.69530380
108Hematopoietic cell lineage_Homo sapiens_hsa046400.68705082
109beta-Alanine metabolism_Homo sapiens_hsa004100.68617602
110Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68189639
111Galactose metabolism_Homo sapiens_hsa000520.67406187
112Systemic lupus erythematosus_Homo sapiens_hsa053220.65897709
113RNA degradation_Homo sapiens_hsa030180.65862129
114Leishmaniasis_Homo sapiens_hsa051400.65583481
115Primary bile acid biosynthesis_Homo sapiens_hsa001200.64817410
116Peroxisome_Homo sapiens_hsa041460.64633979
117Steroid biosynthesis_Homo sapiens_hsa001000.64364057
118ABC transporters_Homo sapiens_hsa020100.63856595
119Sulfur metabolism_Homo sapiens_hsa009200.62933010
120MAPK signaling pathway_Homo sapiens_hsa040100.62082271
121Long-term depression_Homo sapiens_hsa047300.61948119
122RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61776062
123Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61234885
124Intestinal immune network for IgA production_Homo sapiens_hsa046720.60564981
125Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59728874
126Ether lipid metabolism_Homo sapiens_hsa005650.59347380
127Basal transcription factors_Homo sapiens_hsa030220.56761321
128Tryptophan metabolism_Homo sapiens_hsa003800.56459982
129Butanoate metabolism_Homo sapiens_hsa006500.56083904
130Cyanoamino acid metabolism_Homo sapiens_hsa004600.55643502
131Huntingtons disease_Homo sapiens_hsa050160.55244617
132Metabolic pathways_Homo sapiens_hsa011000.55054373
133Dorso-ventral axis formation_Homo sapiens_hsa043200.53557355
134Basal cell carcinoma_Homo sapiens_hsa052170.53386384
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53038098
136Long-term potentiation_Homo sapiens_hsa047200.52847319
137Arachidonic acid metabolism_Homo sapiens_hsa005900.51782619
138NF-kappa B signaling pathway_Homo sapiens_hsa040640.49932973
139Lysosome_Homo sapiens_hsa041420.47423305
140Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46786521
141Rheumatoid arthritis_Homo sapiens_hsa053230.46179190
142Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45465972
143Viral carcinogenesis_Homo sapiens_hsa052030.45280979
144Ras signaling pathway_Homo sapiens_hsa040140.45279395
145Pyruvate metabolism_Homo sapiens_hsa006200.44322678
146NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44294849
147Apoptosis_Homo sapiens_hsa042100.44207977
148Graft-versus-host disease_Homo sapiens_hsa053320.43343762
149Ovarian steroidogenesis_Homo sapiens_hsa049130.42950092
150Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42722862
151Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41903864
152Vascular smooth muscle contraction_Homo sapiens_hsa042700.41288843
153SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41166538
154B cell receptor signaling pathway_Homo sapiens_hsa046620.38984310
155Shigellosis_Homo sapiens_hsa051310.36966861
156Histidine metabolism_Homo sapiens_hsa003400.36676257
157Hepatitis B_Homo sapiens_hsa051610.36491812
158Glutathione metabolism_Homo sapiens_hsa004800.33901226
159Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33879359
160Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33813034
161Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33668342
162Wnt signaling pathway_Homo sapiens_hsa043100.32467355
163Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31984548
164Arginine and proline metabolism_Homo sapiens_hsa003300.31722545
165Alzheimers disease_Homo sapiens_hsa050100.31174920
166Influenza A_Homo sapiens_hsa051640.29289597
167Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27510920
168Pertussis_Homo sapiens_hsa051330.24657208
169T cell receptor signaling pathway_Homo sapiens_hsa046600.22332500
170Propanoate metabolism_Homo sapiens_hsa006400.22330346

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