LCN10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the lipocalin family, such as LCN10, have a common structure consisting of an 8-stranded antiparallel beta-barrel that forms a cup-shaped ligand-binding pocket or calyx. Lipocalins generally bind small hydrophobic ligands and transport them to specific cells (Suzuki et al., 2004 [PubMed 15363845]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of chronic inflammatory response (GO:0002676)9.31855662
2single fertilization (GO:0007338)8.64142545
3heterotypic cell-cell adhesion (GO:0034113)8.55617722
4tryptophan catabolic process (GO:0006569)8.52293662
5indole-containing compound catabolic process (GO:0042436)8.52293662
6indolalkylamine catabolic process (GO:0046218)8.52293662
7negative regulation of interleukin-10 production (GO:0032693)7.62119664
8positive regulation of type 2 immune response (GO:0002830)7.58633472
9tryptophan metabolic process (GO:0006568)7.34540408
10positive regulation of gamma-delta T cell activation (GO:0046645)5.87547805
11aromatic amino acid family catabolic process (GO:0009074)5.77554582
12fertilization (GO:0009566)5.70708114
13amine catabolic process (GO:0009310)5.51400159
14cellular biogenic amine catabolic process (GO:0042402)5.51400159
15regulation of memory T cell differentiation (GO:0043380)5.47870759
16indolalkylamine metabolic process (GO:0006586)5.45197212
17negative regulation of interleukin-8 production (GO:0032717)5.41279781
18antigen processing and presentation of endogenous antigen (GO:0019883)5.37436562
19negative regulation of cell killing (GO:0031342)5.30878558
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.30878558
21negative regulation of T-helper cell differentiation (GO:0045623)5.21680634
22negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)5.21680634
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.89441079
24positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.88654394
25negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.83757749
26benzene-containing compound metabolic process (GO:0042537)4.80461070
27regulation of dendritic cell antigen processing and presentation (GO:0002604)4.76284080
28B cell receptor signaling pathway (GO:0050853)4.73086276
29antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.65878931
30positive regulation of T-helper cell differentiation (GO:0045624)4.59674573
31digestion (GO:0007586)4.59103939
32antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.51860717
33positive regulation of cell-cell adhesion (GO:0022409)4.51624220
34regulation of B cell receptor signaling pathway (GO:0050855)4.51163697
35epithelial cell morphogenesis (GO:0003382)4.50634996
36regulation of T-helper 2 cell differentiation (GO:0045628)4.50631970
37positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)4.42927024
38negative regulation of T cell apoptotic process (GO:0070233)4.40708268
39regulation of gamma-delta T cell differentiation (GO:0045586)4.39861907
40negative regulation of endopeptidase activity (GO:0010951)4.38765596
41regulation of T-helper 1 cell differentiation (GO:0045625)4.34560880
42regulation of gamma-delta T cell activation (GO:0046643)4.30194140
43aromatic amino acid family metabolic process (GO:0009072)4.24096099
44positive regulation of B cell differentiation (GO:0045579)4.21327258
45negative regulation of peptidase activity (GO:0010466)4.19347695
46antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.18558930
47regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)4.17839300
48regulation of antigen processing and presentation (GO:0002577)4.15232005
49defense response to protozoan (GO:0042832)4.14650625
50positive regulation of defense response to virus by host (GO:0002230)4.06355244
51negative thymic T cell selection (GO:0045060)4.03228122
52regulation of type 2 immune response (GO:0002828)3.98839301
53response to interleukin-15 (GO:0070672)3.97279655
54regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.96586969
55regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.93894009
56regulation of activation of Janus kinase activity (GO:0010533)3.89550884
57indole-containing compound metabolic process (GO:0042430)3.89538534
58regulation of T-helper cell differentiation (GO:0045622)3.88724864
59regulation of T-helper 1 type immune response (GO:0002825)3.88168946
60activated T cell proliferation (GO:0050798)3.88084637
61transepithelial transport (GO:0070633)3.87677776
62immunoglobulin mediated immune response (GO:0016064)3.86540334
63positive thymic T cell selection (GO:0045059)3.86278469
64positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.83470486
65regulation of clathrin-mediated endocytosis (GO:2000369)3.80996828
66positive regulation of antigen processing and presentation (GO:0002579)3.78019508
67positive regulation of T cell mediated cytotoxicity (GO:0001916)3.77536751
68positive regulation of interleukin-17 production (GO:0032740)3.77226662
69response to protozoan (GO:0001562)3.76908366
70negative T cell selection (GO:0043383)3.76425899
71regulation of B cell differentiation (GO:0045577)3.74586917
72regulation of T cell mediated cytotoxicity (GO:0001914)3.69274878
73positive regulation of T-helper 1 type immune response (GO:0002827)3.66083451
74positive regulation of neutrophil chemotaxis (GO:0090023)3.63886685
75positive regulation of neutrophil migration (GO:1902624)3.63886685
76defense response to bacterium (GO:0042742)3.63037681
77sulfur amino acid catabolic process (GO:0000098)3.60338849
78reverse cholesterol transport (GO:0043691)3.58206493
79negative regulation of alpha-beta T cell differentiation (GO:0046639)3.57182588
80regulation of alpha-beta T cell proliferation (GO:0046640)3.52897828
81positive regulation of alpha-beta T cell proliferation (GO:0046641)3.47604698
82N-acetylneuraminate metabolic process (GO:0006054)3.47558185
83thymic T cell selection (GO:0045061)3.44886273
84regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.42578559
85negative regulation of alpha-beta T cell activation (GO:0046636)3.42073462
86positive regulation of alpha-beta T cell differentiation (GO:0046638)3.38066234
87detection of bacterium (GO:0016045)3.35965910
88cellular response to exogenous dsRNA (GO:0071360)3.35032782
89negative regulation of protein autophosphorylation (GO:0031953)3.33909439
90cellular response to interleukin-15 (GO:0071350)3.23833009
91positive regulation of granulocyte chemotaxis (GO:0071624)3.19030110
92response to bacterium (GO:0009617)3.18217465
93type I interferon signaling pathway (GO:0060337)3.17334653
94cellular response to type I interferon (GO:0071357)3.17334653
95regulation of alpha-beta T cell differentiation (GO:0046637)3.15954198
96response to type I interferon (GO:0034340)3.15774171
97detection of other organism (GO:0098543)3.15738665
98negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.14842358
99regulation of macrophage activation (GO:0043030)3.09571435
100positive regulation of T cell differentiation (GO:0045582)3.09379720
101negative regulation of lymphocyte mediated immunity (GO:0002707)3.05114754
102phospholipid homeostasis (GO:0055091)3.03849518
103positive regulation of lymphocyte differentiation (GO:0045621)3.01788469
104regulation of defense response to virus by host (GO:0050691)3.01225368
105positive regulation of natural killer cell activation (GO:0032816)3.00012895
106seminiferous tubule development (GO:0072520)24.9778230
107antigen receptor-mediated signaling pathway (GO:0050851)2.99179686
108negative regulation of T cell mediated immunity (GO:0002710)2.97488982
109positive regulation of immunoglobulin production (GO:0002639)2.95938555
110interferon-gamma secretion (GO:0072643)2.93985148
111B cell mediated immunity (GO:0019724)2.93830830
112interferon-gamma-mediated signaling pathway (GO:0060333)2.92914406
113T cell selection (GO:0045058)2.92297035
114regulation of regulatory T cell differentiation (GO:0045589)2.91194576
115regulation of interleukin-17 production (GO:0032660)2.91156195
116response to interferon-alpha (GO:0035455)2.91024162
117positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.90744851
118regulation of neutrophil chemotaxis (GO:0090022)2.90482227
119regulation of neutrophil migration (GO:1902622)2.90482227
120T cell proliferation (GO:0042098)2.89919185
121alpha-linolenic acid metabolic process (GO:0036109)2.89641196
122neutrophil activation involved in immune response (GO:0002283)2.89094485
123fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.88851915
124negative regulation of leukocyte mediated immunity (GO:0002704)2.88449256
125regulation of lipoprotein metabolic process (GO:0050746)2.87335409
126positive T cell selection (GO:0043368)2.86999784
127regulation of leukocyte mediated cytotoxicity (GO:0001910)2.83811588
128regulation of MHC class I biosynthetic process (GO:0045343)2.83603348
129negative regulation of proteolysis (GO:0045861)2.80608296
130regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.79289300
131regulation of alpha-beta T cell activation (GO:0046634)2.78701357
132positive regulation of granulocyte differentiation (GO:0030854)2.78156936
133Peyers patch development (GO:0048541)2.78055069
134mucosal-associated lymphoid tissue development (GO:0048537)2.78055069
135positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.77600247
136negative regulation of glycogen biosynthetic process (GO:0045719)2.77539412
137positive regulation of alpha-beta T cell activation (GO:0046635)2.77536277
138regulation of activated T cell proliferation (GO:0046006)2.76840882
139O-glycan processing (GO:0016266)2.74676368
140negative regulation of lymphocyte apoptotic process (GO:0070229)2.71385191
141negative regulation of protein maturation (GO:1903318)2.70329013
142negative regulation of protein processing (GO:0010955)2.70329013
143positive regulation of cellular amide metabolic process (GO:0034250)2.70245098
144glial cell proliferation (GO:0014009)2.69304630
145cysteine metabolic process (GO:0006534)2.67863924
146positive regulation of interleukin-12 production (GO:0032735)2.67276304
147regulation of beta-amyloid formation (GO:1902003)2.64997755
148sialylation (GO:0097503)2.62181879
149ethanol oxidation (GO:0006069)2.61344844
150complement activation, alternative pathway (GO:0006957)2.60039792
151high-density lipoprotein particle remodeling (GO:0034375)2.59715217
152columnar/cuboidal epithelial cell development (GO:0002066)2.57182647
153negative regulation of hydrolase activity (GO:0051346)2.52370275
154negative regulation of glycogen metabolic process (GO:0070874)2.51363508
155negative regulation of receptor-mediated endocytosis (GO:0048261)2.49300952
156hormone catabolic process (GO:0042447)2.46477849
157negative regulation of interleukin-6 production (GO:0032715)2.45200594
158low-density lipoprotein particle clearance (GO:0034383)2.37947000
159regulation of endopeptidase activity (GO:0052548)2.37753926
160valine metabolic process (GO:0006573)2.34705858
161regulation of amyloid precursor protein catabolic process (GO:1902991)2.32752076
162L-serine transport (GO:0015825)2.28286928
163regulation of interleukin-10 production (GO:0032653)2.26550614
164alpha-amino acid catabolic process (GO:1901606)2.26423591
165regulation of peptidase activity (GO:0052547)2.26147100
166lipid catabolic process (GO:0016042)2.24461063
167cellular amino acid catabolic process (GO:0009063)2.21260639
168regulation of T cell apoptotic process (GO:0070232)2.21037837
169negative regulation of T cell proliferation (GO:0042130)2.19177365
170myeloid cell homeostasis (GO:0002262)2.17859502
171cellular response to epidermal growth factor stimulus (GO:0071364)2.14997266
172myelin maintenance (GO:0043217)2.14932006
173response to misfolded protein (GO:0051788)2.14630853
174pyrimidine ribonucleoside catabolic process (GO:0046133)2.14580228
175triglyceride catabolic process (GO:0019433)2.12035290
176negative regulation of tumor necrosis factor production (GO:0032720)2.10806073
177plasma lipoprotein particle remodeling (GO:0034369)2.07765975
178protein-lipid complex remodeling (GO:0034368)2.07765975
179macromolecular complex remodeling (GO:0034367)2.07765975
180acylglycerol catabolic process (GO:0046464)2.05490841
181neutral lipid catabolic process (GO:0046461)2.05490841
182regulation of apoptotic cell clearance (GO:2000425)2.05033178
183COPI coating of Golgi vesicle (GO:0048205)2.04486708
184Golgi transport vesicle coating (GO:0048200)2.04486708
185erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.04006236
186L-phenylalanine catabolic process (GO:0006559)2.04006236
187negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.02243712
188positive regulation of sterol transport (GO:0032373)2.01573991
189positive regulation of cholesterol transport (GO:0032376)2.01573991
190regulation of T cell tolerance induction (GO:0002664)14.6993039
191production of molecular mediator involved in inflammatory response (GO:0002532)14.3885354
192positive regulation of tolerance induction (GO:0002645)12.5750890
193sperm capacitation (GO:0048240)11.2562669
194regulation of tolerance induction (GO:0002643)10.9396612
195kynurenine metabolic process (GO:0070189)10.4677046

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.11789529
2GATA1_22025678_ChIP-Seq_K562_Human5.46876904
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.20476096
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human4.65013464
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.32706707
6IKZF1_21737484_ChIP-ChIP_HCT116_Human4.00199027
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.94034116
8AR_21572438_ChIP-Seq_LNCaP_Human3.46386942
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.07674838
10SCL_19346495_ChIP-Seq_HPC-7_Human3.04881946
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.03941706
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.02469765
13MYC_22102868_ChIP-Seq_BL_Human2.93466709
14RUNX_20019798_ChIP-Seq_JUKART_Human2.88154940
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.87939354
16VDR_21846776_ChIP-Seq_THP-1_Human2.71670975
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.70159348
18ESR1_21235772_ChIP-Seq_MCF-7_Human2.68741418
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.59858644
20E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.57455826
21CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.55222542
22ZNF263_19887448_ChIP-Seq_K562_Human2.46120690
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.45012566
24IRF8_21731497_ChIP-ChIP_J774_Mouse2.43083793
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.38872950
26RXR_22158963_ChIP-Seq_LIVER_Mouse2.26656609
27LXR_22158963_ChIP-Seq_LIVER_Mouse2.24576800
28MYB_26560356_Chip-Seq_TH2_Human2.22606342
29UTX_26944678_Chip-Seq_JUKART_Human2.21816671
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.18529600
31DNAJC2_21179169_ChIP-ChIP_NT2_Human2.16870687
32VDR_24763502_ChIP-Seq_THP-1_Human2.15893452
33ESR2_21235772_ChIP-Seq_MCF-7_Human2.13288397
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.11697793
35SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.11254678
36SPI1_23127762_ChIP-Seq_K562_Human2.10239355
37CLOCK_20551151_ChIP-Seq_293T_Human2.08939019
38MAF_26560356_Chip-Seq_TH1_Human2.06610640
39TRIM28_21343339_ChIP-Seq_HEK293_Human2.04133290
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.96386605
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.90384218
42GATA1_19941827_ChIP-Seq_MEL_Mouse1.85786188
43GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.84306174
44MYB_26560356_Chip-Seq_TH1_Human1.81870598
45LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.81659589
46PPARA_22158963_ChIP-Seq_LIVER_Mouse1.81139850
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81061656
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.80204979
49* RUNX1_22412390_ChIP-Seq_EML_Mouse1.79383983
50IRF8_27001747_Chip-Seq_BMDM_Mouse1.78739710
51SPI1_23547873_ChIP-Seq_NB4_Human1.71712524
52EGR1_23403033_ChIP-Seq_LIVER_Mouse1.69099199
53PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.68284676
54* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.66616251
55SMAD1_18555785_Chip-Seq_ESCs_Mouse1.64081786
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.62585570
57TET1_21451524_ChIP-Seq_MESCs_Mouse1.62376946
58MAF_26560356_Chip-Seq_TH2_Human1.61871101
59NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.60669187
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60095584
61REST_19997604_ChIP-ChIP_NEURONS_Mouse1.58846432
62GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.58410169
63GATA3_27048872_Chip-Seq_THYMUS_Human1.56368843
64STAT1_17558387_ChIP-Seq_HELA_Human1.54471888
65EZH2_18974828_ChIP-Seq_MESCs_Mouse1.54396894
66RNF2_18974828_ChIP-Seq_MESCs_Mouse1.54396894
67LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.54111979
68FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.52596760
69* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.51845507
70SMAD4_21741376_ChIP-Seq_HESCs_Human1.51618791
71NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48140553
72RAD21_21589869_ChIP-Seq_MESCs_Mouse1.47840648
73TCF7_22412390_ChIP-Seq_EML_Mouse1.45401847
74SOX2_22085726_ChIP-Seq_NPCs_Mouse1.45089779
75MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.44882255
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.42627063
77TP63_17297297_ChIP-ChIP_HaCaT_Human1.42437983
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40269874
79SMAD3_21741376_ChIP-Seq_HESCs_Human1.39704994
80* GATA3_21867929_ChIP-Seq_TH1_Mouse1.38065826
81KDM2B_26808549_Chip-Seq_DND41_Human1.37807055
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37262042
83STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.37230165
84BRD4_27068464_Chip-Seq_AML-cells_Mouse1.36705722
85GATA3_26560356_Chip-Seq_TH2_Human1.36173243
86SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.34994415
87ESRRB_18555785_Chip-Seq_ESCs_Mouse1.33589227
88MYB_21317192_ChIP-Seq_ERMYB_Mouse1.32360421
89GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.29652565
90* BCL6_27268052_Chip-Seq_Bcells_Human1.28396845
91TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.27352825
92CIITA_25753668_ChIP-Seq_RAJI_Human1.27026052
93STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.24927899
94RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.24453335
95P68_20966046_ChIP-Seq_HELA_Human1.22847717
96GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22756188
97CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22321763
98SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.22069293
99BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.21720764
100SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21686067
101VDR_24787735_ChIP-Seq_THP-1_Human1.19278939
102SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18687361
103* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17963820
104SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.16955057
105SALL4_22934838_ChIP-ChIP_CD34+_Human1.16442349
106RACK7_27058665_Chip-Seq_MCF-7_Human1.15759351
107* FLI1_21867929_ChIP-Seq_CD8_Mouse1.15757958
108KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15750571
109GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15058548
110JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.14839600
111EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.14470780
112SPI1_20517297_ChIP-Seq_HL60_Human1.14153851
113GATA2_21666600_ChIP-Seq_HMVEC_Human1.13219472
114CTCF_18555785_Chip-Seq_ESCs_Mouse1.12793188
115MYC_27129775_Chip-Seq_CORNEA_Mouse1.12747767
116BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.10168634
117TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09504750
118MYC_19915707_ChIP-ChIP_AK7_Human1.06895192
119GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05505569
120NFE2_27457419_Chip-Seq_LIVER_Mouse1.05048750
121PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.04890032
122NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04576313
123MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03860429
124THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03790931
125SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02199774
126ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02042657
127SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.01759508
128FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01659378
129* ELF1_20517297_ChIP-Seq_JURKAT_Human1.01533113
130CBX2_27304074_Chip-Seq_ESCs_Mouse1.00838020
131DROSHA_22980978_ChIP-Seq_HELA_Human1.00647542
132ELK3_25401928_ChIP-Seq_HUVEC_Human1.00613801
133TP53_20018659_ChIP-ChIP_R1E_Mouse1.00537629
134FOXH1_21741376_ChIP-Seq_ESCs_Human0.99992429
135SMRT_27268052_Chip-Seq_Bcells_Human0.99227589
136FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98605112
137SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.98344676
138BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98069783
139SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.97538908
140* BCOR_27268052_Chip-Seq_Bcells_Human0.97500743
141KDM2B_26808549_Chip-Seq_REH_Human0.97470438
142EZH2_27304074_Chip-Seq_ESCs_Mouse0.95862311
143GATA1_19941826_ChIP-Seq_K562_Human0.95633818
144TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95550140
145NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95030091
146SOX2_20726797_ChIP-Seq_SW620_Human0.92736509
147ETS1_21867929_ChIP-Seq_TH2_Mouse0.92169109
148KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.92023367
149PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91230143
150REST_18959480_ChIP-ChIP_MESCs_Mouse0.90702700
151SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.90380121
152GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90191267
153ELK4_26923725_Chip-Seq_MESODERM_Mouse0.89466123
154PU_27001747_Chip-Seq_BMDM_Mouse0.89333209
155GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89237772
156PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89013807
157FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.88778785
158ERG_21242973_ChIP-ChIP_JURKAT_Human0.87967411
159PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87543127
160RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.87384648
161LXR_22292898_ChIP-Seq_THP-1_Human0.86422991
162PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.86399729
163EZH2_27294783_Chip-Seq_NPCs_Mouse0.86222404
164KDM2B_26808549_Chip-Seq_K562_Human0.85954164
165NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.85834032
166EGR1_19374776_ChIP-ChIP_THP-1_Human0.85692410
167NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.85479294
168* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.85189682
169* P300_27268052_Chip-Seq_Bcells_Human0.84631773
170CTCF_27219007_Chip-Seq_ERYTHROID_Human0.84501262
171NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.84375058
172RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.84348268
173CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.83969602
174SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.83770251
175PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83300022
176WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.83289494
177SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.83221256
178HTT_18923047_ChIP-ChIP_STHdh_Human0.82782435
179SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.81849243
180TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81634537
181POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.81634537
182STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.81572569
183WT1_19549856_ChIP-ChIP_CCG9911_Human0.81459428
184Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.81379598
185AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81283893
186PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.81022877
187RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.79557493
188* E2F1_20622854_ChIP-Seq_HELA_Human0.78548770
189KDM2B_26808549_Chip-Seq_JURKAT_Human0.77589485
190TAF2_19829295_ChIP-Seq_ESCs_Human0.76803124

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis6.72205000
2MP0003303_peritoneal_inflammation5.14603677
3MP0002254_reproductive_system_inflammat5.03955434
4MP0001835_abnormal_antigen_presentation4.88490503
5MP0010234_abnormal_vibrissa_follicle4.31677558
6MP0004043_abnormal_pH_regulation4.30990949
7MP0005387_immune_system_phenotype3.99983171
8MP0001790_abnormal_immune_system3.99983171
9MP0002139_abnormal_hepatobiliary_system3.94704801
10MP0001800_abnormal_humoral_immune3.55973548
11MP0005671_abnormal_response_to3.37434666
12MP0002009_preneoplasia3.13368755
13MP0005000_abnormal_immune_tolerance3.07632145
14MP0000537_abnormal_urethra_morphology3.05388230
15MP0005410_abnormal_fertilization2.99999797
16MP0000685_abnormal_immune_system2.95437315
17MP0005058_abnormal_lysosome_morphology2.94655267
18MP0003436_decreased_susceptibility_to2.84520099
19MP0002723_abnormal_immune_serum2.73909215
20MP0003763_abnormal_thymus_physiology2.69793061
21MP0009785_altered_susceptibility_to2.68646412
22MP0002452_abnormal_antigen_presenting2.66047672
23MP0003329_amyloid_beta_deposits2.59224193
24MP0002420_abnormal_adaptive_immunity2.54856485
25MP0001819_abnormal_immune_cell2.51491281
26MP0003724_increased_susceptibility_to2.50290241
27MP0005025_abnormal_response_to2.49334217
28MP0002419_abnormal_innate_immunity2.49207389
29MP0002148_abnormal_hypersensitivity_rea2.48790484
30MP0000465_gastrointestinal_hemorrhage2.46660758
31MP0005075_abnormal_melanosome_morpholog2.42738698
32MP0001873_stomach_inflammation2.39079394
33MP0002168_other_aberrant_phenotype2.11723056
34MP0004145_abnormal_muscle_electrophysio2.07712269
35MP0002398_abnormal_bone_marrow2.05168605
36MP0004381_abnormal_hair_follicle2.04515589
37MP0001986_abnormal_taste_sensitivity1.99447703
38MP0000716_abnormal_immune_system1.97352880
39MP0000003_abnormal_adipose_tissue1.88191644
40MP0000604_amyloidosis1.84476676
41MP0005360_urolithiasis1.84422828
42MP0010329_abnormal_lipoprotein_level1.83719923
43MP0003300_gastrointestinal_ulcer1.81213123
44MP0002166_altered_tumor_susceptibility1.76354812
45MP0010155_abnormal_intestine_physiology1.74559070
46MP0002405_respiratory_system_inflammati1.73695284
47MP0000015_abnormal_ear_pigmentation1.73592869
48MP0000689_abnormal_spleen_morphology1.71144480
49MP0005174_abnormal_tail_pigmentation1.68894140
50MP0003566_abnormal_cell_adhesion1.67012403
51MP0005365_abnormal_bile_salt1.66594215
52MP0005464_abnormal_platelet_physiology1.66421785
53MP0003172_abnormal_lysosome_physiology1.65418327
54MP0001501_abnormal_sleep_pattern1.62555051
55MP0002722_abnormal_immune_system1.61726086
56MP0001845_abnormal_inflammatory_respons1.53091254
57MP0002429_abnormal_blood_cell1.52893912
58MP0004264_abnormal_extraembryonic_tissu1.48153211
59MP0001765_abnormal_ion_homeostasis1.45260433
60MP0008438_abnormal_cutaneous_collagen1.40633482
61MP0009278_abnormal_bone_marrow1.39005863
62MP0003646_muscle_fatigue1.38987334
63MP0004084_abnormal_cardiac_muscle1.37775107
64MP0005085_abnormal_gallbladder_physiolo1.37253410
65MP0004885_abnormal_endolymph1.36673556
66MP0001853_heart_inflammation1.36524383
67MP0004185_abnormal_adipocyte_glucose1.35864203
68MP0000534_abnormal_ureter_morphology1.35747385
69MP0005375_adipose_tissue_phenotype1.34354882
70MP0001533_abnormal_skeleton_physiology1.32841288
71MP0000703_abnormal_thymus_morphology1.31137720
72MP0009643_abnormal_urine_homeostasis1.28988850
73MP0003828_pulmonary_edema1.28663353
74MP0004130_abnormal_muscle_cell1.28269143
75MP0003690_abnormal_glial_cell1.27795762
76MP0000538_abnormal_urinary_bladder1.26607984
77MP0001440_abnormal_grooming_behavior1.23286538
78MP0004858_abnormal_nervous_system1.22637633
79MP0001756_abnormal_urination1.22526700
80MP0004947_skin_inflammation1.19917381
81MP0008469_abnormal_protein_level1.18617262
82MP0005275_abnormal_skin_tensile1.17463845
83MP0004859_abnormal_synaptic_plasticity1.16574282
84MP0002837_dystrophic_cardiac_calcinosis1.15220819
85MP0002396_abnormal_hematopoietic_system1.14499736
86MP0002006_tumorigenesis1.13540128
87MP0003866_abnormal_defecation1.11540929
88MP0002796_impaired_skin_barrier1.11177211
89MP0005584_abnormal_enzyme/coenzyme_acti1.10607438
90MP0004036_abnormal_muscle_relaxation1.10268096
91MP0003705_abnormal_hypodermis_morpholog1.10228341
92MP0000747_muscle_weakness1.09304313
93MP0004808_abnormal_hematopoietic_stem1.07282507
94MP0005332_abnormal_amino_acid1.07093443
95MP0005636_abnormal_mineral_homeostasis1.04746439
96MP0000372_irregular_coat_pigmentation1.04318706
97MP0002089_abnormal_postnatal_growth/wei1.02402986
98MP0008875_abnormal_xenobiotic_pharmacok1.01811983
99MP0002118_abnormal_lipid_homeostasis0.99350559
100MP0009764_decreased_sensitivity_to0.98621071
101MP0003632_abnormal_nervous_system0.96870958
102MP0005397_hematopoietic_system_phenotyp0.94980325
103MP0001545_abnormal_hematopoietic_system0.94980325
104MP0010678_abnormal_skin_adnexa0.94958360
105MP0005083_abnormal_biliary_tract0.94763303
106MP0002896_abnormal_bone_mineralization0.93803201
107MP0009379_abnormal_foot_pigmentation0.93220082
108MP0002132_abnormal_respiratory_system0.92431798
109MP0002998_abnormal_bone_remodeling0.92041939
110MP0006082_CNS_inflammation0.91659601
111MP0000858_altered_metastatic_potential0.89998800
112MP0003075_altered_response_to0.88008706
113MP0003252_abnormal_bile_duct0.87721071
114MP0005666_abnormal_adipose_tissue0.87373390
115MP0004484_altered_response_of0.86797977
116MP0001851_eye_inflammation0.86653070
117MP0003191_abnormal_cellular_cholesterol0.84419641
118MP0009765_abnormal_xenobiotic_induced0.83778532
119MP0003698_abnormal_male_reproductive0.83556322
120MP0009763_increased_sensitivity_to0.82628724
121MP0003315_abnormal_perineum_morphology0.82466740
122MP0002136_abnormal_kidney_physiology0.81269807
123MP0005310_abnormal_salivary_gland0.80055398
124MP0009780_abnormal_chondrocyte_physiolo0.78903696
125MP0002909_abnormal_adrenal_gland0.78840487
126MP0000920_abnormal_myelination0.78319538
127MP0003638_abnormal_response/metabolism_0.77098595
128MP0005395_other_phenotype0.76140805
129MP0004510_myositis0.75418091
130MP0006138_congestive_heart_failure0.74994701
131MP0001663_abnormal_digestive_system0.73983445
132MP0003806_abnormal_nucleotide_metabolis0.73856296
133MP0002933_joint_inflammation0.73393258
134MP0000249_abnormal_blood_vessel0.73171053
135MP0003448_altered_tumor_morphology0.72943742
136MP0008961_abnormal_basal_metabolism0.71438857
137MP0001544_abnormal_cardiovascular_syste0.70988967
138MP0005385_cardiovascular_system_phenoty0.70988967
139MP0002733_abnormal_thermal_nociception0.68140223
140MP0005670_abnormal_white_adipose0.67683402
141MP0003631_nervous_system_phenotype0.67384267
142MP0000609_abnormal_liver_physiology0.67225807
143MP0008874_decreased_physiological_sensi0.66520925
144MP0002127_abnormal_cardiovascular_syste0.65709281
145MP0003011_delayed_dark_adaptation0.65471185
146MP0000343_altered_response_to0.65310011
147MP0001666_abnormal_nutrient_absorption0.64626785
148MP0004270_analgesia0.64285736
149MP0005165_increased_susceptibility_to0.63768203
150MP0002138_abnormal_hepatobiliary_system0.63077440
151MP0009384_cardiac_valve_regurgitation0.62608989
152MP0003879_abnormal_hair_cell0.62346017
153MP0002295_abnormal_pulmonary_circulatio0.62034239
154MP0005319_abnormal_enzyme/_coenzyme0.61713210
155MP0002332_abnormal_exercise_endurance0.60456822
156MP0002095_abnormal_skin_pigmentation0.60451555
157MP0002876_abnormal_thyroid_physiology0.60140624
158MP0005408_hypopigmentation0.57906866
159MP0002019_abnormal_tumor_incidence0.57372750
160MP0003633_abnormal_nervous_system0.57221343
161MP0003635_abnormal_synaptic_transmissio0.55785089
162MP0009115_abnormal_fat_cell0.55433309
163MP0005623_abnormal_meninges_morphology0.55299938
164MP0009333_abnormal_splenocyte_physiolog0.55077906
165MP0005334_abnormal_fat_pad0.54804722
166MP0003123_paternal_imprinting0.54705265
167MP0005330_cardiomyopathy0.53938354
168MP0003634_abnormal_glial_cell0.53364624
169MP0001348_abnormal_lacrimal_gland0.53049733
170MP0005166_decreased_susceptibility_to0.50755570
171MP0002735_abnormal_chemical_nociception0.50474533
172MP0001881_abnormal_mammary_gland0.50018865
173MP0005164_abnormal_response_to0.49317424
174MP0005535_abnormal_body_temperature0.49015142
175MP0004019_abnormal_vitamin_homeostasis0.48595136
176MP0000462_abnormal_digestive_system0.48305638
177MP0009053_abnormal_anal_canal0.47174857
178MP0001970_abnormal_pain_threshold0.46819820

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)6.71134951
2Testicular atrophy (HP:0000029)5.53327431
3Stomatitis (HP:0010280)5.50534307
4Panhypogammaglobulinemia (HP:0003139)5.24326054
5Myocardial infarction (HP:0001658)5.22993856
6Abnormal delayed hypersensitivity skin test (HP:0002963)5.01038687
7Gonadotropin excess (HP:0000837)4.97376188
8Hypophosphatemic rickets (HP:0004912)4.74849385
9Colitis (HP:0002583)4.72090196
10Potter facies (HP:0002009)4.67053634
11Facial shape deformation (HP:0011334)4.67053634
12IgG deficiency (HP:0004315)4.61002963
13Vascular calcification (HP:0004934)4.52714327
14Complement deficiency (HP:0004431)4.31849795
15Cardiovascular calcification (HP:0011915)4.20068459
16Meningitis (HP:0001287)4.16750103
17Recurrent cutaneous fungal infections (HP:0011370)4.06385073
18Chronic mucocutaneous candidiasis (HP:0002728)4.06385073
19Gastrointestinal stroma tumor (HP:0100723)4.04274344
20Neurofibrillary tangles (HP:0002185)4.02580430
21Myositis (HP:0100614)4.00635298
22Calf muscle hypertrophy (HP:0008981)3.94491796
23Cerebral inclusion bodies (HP:0100314)3.93249294
24Genetic anticipation (HP:0003743)3.90111641
25Gastrointestinal inflammation (HP:0004386)3.85892185
26Inflammation of the large intestine (HP:0002037)3.83394141
27Recurrent fungal infections (HP:0002841)3.78930899
28Prostate neoplasm (HP:0100787)3.73370422
29Choroideremia (HP:0001139)3.73026139
30Recurrent bronchitis (HP:0002837)3.68952363
31Muscle hypertrophy of the lower extremities (HP:0008968)3.68034805
32Eczematoid dermatitis (HP:0000976)3.66240195
33Recurrent abscess formation (HP:0002722)3.65227591
34Malnutrition (HP:0004395)3.63121114
35Recurrent bacterial skin infections (HP:0005406)3.58812154
36Abnormality of secondary sexual hair (HP:0009888)3.41617174
37Abnormality of the axillary hair (HP:0100134)3.41617174
38Cellulitis (HP:0100658)3.40327781
39Mediastinal lymphadenopathy (HP:0100721)3.38186785
40Recurrent sinusitis (HP:0011108)3.37832309
41Abnormality of T cells (HP:0002843)3.36133356
42Encephalitis (HP:0002383)3.35656152
43Recurrent viral infections (HP:0004429)3.29739501
44Abnormal hemoglobin (HP:0011902)3.26073539
45Vasculitis (HP:0002633)3.25621048
46Infantile muscular hypotonia (HP:0008947)3.24430446
47Abnormality of T cell physiology (HP:0011840)3.19585079
48Recurrent skin infections (HP:0001581)3.18380529
49Abnormality of complement system (HP:0005339)3.16175703
50Orchitis (HP:0100796)3.14492642
51Papilloma (HP:0012740)3.13722216
52Verrucae (HP:0200043)3.13722216
53Abnormality of macrophages (HP:0004311)3.13067806
54Neoplasm of the heart (HP:0100544)3.10780880
55Retrobulbar optic neuritis (HP:0100654)3.09712879
56Optic neuritis (HP:0100653)3.09712879
57Choreoathetosis (HP:0001266)3.01510260
58Widely patent fontanelles and sutures (HP:0004492)2.99773698
59Agitation (HP:0000713)2.99548453
60Xanthomatosis (HP:0000991)2.94647274
61Deep venous thrombosis (HP:0002625)2.93144242
62Recurrent gram-negative bacterial infections (HP:0005420)2.92853064
63Supranuclear gaze palsy (HP:0000605)2.92713814
64Rickets (HP:0002748)2.92458130
65Pulmonary infiltrates (HP:0002113)2.89972594
66Intention tremor (HP:0002080)2.89098260
67Ketoacidosis (HP:0001993)2.76925638
68Viral hepatitis (HP:0006562)2.76110213
69Lymphopenia (HP:0001888)2.73549244
70Facial diplegia (HP:0001349)2.71670092
71Gastrointestinal infarctions (HP:0005244)2.69052676
72Clumsiness (HP:0002312)2.62175157
73Spontaneous hematomas (HP:0007420)2.56605141
74Hemiplegia (HP:0002301)2.56470770
75Congenital stationary night blindness (HP:0007642)2.56330581
76Chest pain (HP:0100749)2.56115467
77T lymphocytopenia (HP:0005403)2.55996625
78Gingivitis (HP:0000230)2.55040014
79Pustule (HP:0200039)2.53594253
80Recurrent lower respiratory tract infections (HP:0002783)2.50544574
81Abnormality of cells of the lymphoid lineage (HP:0012140)2.47248871
82Increased IgM level (HP:0003496)2.44126097
83Abnormality of small intestinal villus morphology (HP:0011472)2.42983231
84Villous atrophy (HP:0011473)2.42983231
85Prolonged bleeding time (HP:0003010)2.41984843
86Elevated erythrocyte sedimentation rate (HP:0003565)2.41514977
87Thyroid-stimulating hormone excess (HP:0002925)2.41418637
88Restrictive lung disease (HP:0002091)2.39780232
89Abnormality of T cell number (HP:0011839)2.39486067
90Ketosis (HP:0001946)2.39189001
91Vacuolated lymphocytes (HP:0001922)2.37302058
92Intrahepatic cholestasis (HP:0001406)2.37188454
93Osteomyelitis (HP:0002754)2.36830926
94Arterial thrombosis (HP:0004420)2.36598904
95Hemorrhage of the eye (HP:0011885)2.36250210
96Ragged-red muscle fibers (HP:0003200)2.34353755
97Gingival bleeding (HP:0000225)2.33667710
98Abnormality of the fovea (HP:0000493)2.33613238
99Obstructive lung disease (HP:0006536)2.32698958
100Chronic obstructive pulmonary disease (HP:0006510)2.32698958
101Decreased subcutaneous fat (HP:0001002)2.29874059
102Spastic diplegia (HP:0001264)2.27240873
103Emphysema (HP:0002097)2.26108144
104Abnormality of the prostate (HP:0008775)2.25552797
105Polar cataract (HP:0010696)2.24725518
106Keratoconjunctivitis sicca (HP:0001097)2.24533660
107Epistaxis (HP:0000421)2.23955906
108Keratoconjunctivitis (HP:0001096)2.22982975
109Recurrent pneumonia (HP:0006532)2.21622942
110Increased connective tissue (HP:0009025)2.19802429
111IgM deficiency (HP:0002850)2.19301636
112Hyperglycinuria (HP:0003108)2.19111902
113Acanthosis nigricans (HP:0000956)2.18988214
114Increased neuronal autofluorescent lipopigment (HP:0002074)2.18684246
115Hyporeflexia of lower limbs (HP:0002600)2.18561960
116Sepsis (HP:0100806)2.18370016
117Testicular neoplasm (HP:0010788)2.18369251
118Hemoptysis (HP:0002105)2.17363384
119Leukocytosis (HP:0001974)2.17276599
120Difficulty running (HP:0009046)2.16841239
121Azoospermia (HP:0000027)2.16373063
122Sudden death (HP:0001699)2.15201727
123Focal segmental glomerulosclerosis (HP:0000097)2.15173335
124Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.14124643
125Hypopigmentation of the fundus (HP:0007894)2.14005257
126Abnormality of the fingertips (HP:0001211)2.13827973
127Muscle fiber splitting (HP:0003555)2.13632959
128IgA deficiency (HP:0002720)2.13373829
129Abnormality of aromatic amino acid family metabolism (HP:0004338)2.12323653
130Progressive cerebellar ataxia (HP:0002073)2.11110060
131Gout (HP:0001997)2.10850949
132Abnormal rod and cone electroretinograms (HP:0008323)2.08672316
133Papilledema (HP:0001085)2.08176428
134Thin bony cortex (HP:0002753)2.06784526
135Granulocytopenia (HP:0001913)2.04470743
136Abnormality of the columella (HP:0009929)2.03784843
137Skin nodule (HP:0200036)2.03743808
138Bifid scrotum (HP:0000048)2.03725008
139Abnormality of purine metabolism (HP:0004352)2.02192088
140Xerostomia (HP:0000217)2.02108595
141Pili torti (HP:0003777)2.01210113
142Peripheral hypomyelination (HP:0007182)2.00402234
143Chronic sinusitis (HP:0011109)2.00401839
144Thrombocytosis (HP:0001894)2.00163845
145Increased cerebral lipofuscin (HP:0011813)1.99400129
146Increased IgE level (HP:0003212)1.98671840
147Degeneration of the lateral corticospinal tracts (HP:0002314)1.98322880
148Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.98322880
149Abnormality of glycine metabolism (HP:0010895)1.97717797
150Abnormality of serine family amino acid metabolism (HP:0010894)1.97717797
151Gait ataxia (HP:0002066)1.95348319
152Myokymia (HP:0002411)1.94598987
153Obstructive sleep apnea (HP:0002870)1.94113466
154Dysostosis multiplex (HP:0000943)1.93599075
155Abnormality of the calf musculature (HP:0001430)1.92620655
156Ulnar claw (HP:0001178)1.92253132
157Epidermoid cyst (HP:0200040)1.90764607
158Right ventricular cardiomyopathy (HP:0011663)1.89729304
159Ventricular fibrillation (HP:0001663)1.88196831
160Hyperlipoproteinemia (HP:0010980)1.87596546
161Fatigue (HP:0012378)1.87188870
162Systemic lupus erythematosus (HP:0002725)1.87145308
163Vertigo (HP:0002321)1.86541884
164Slow saccadic eye movements (HP:0000514)1.85641081
165Decreased electroretinogram (ERG) amplitude (HP:0000654)1.85473450
166Pulmonary fibrosis (HP:0002206)1.85411654
167Episodic fever (HP:0001954)1.84522911
168Leukopenia (HP:0001882)1.84520041
169Infertility (HP:0000789)1.83308948
170Hypertriglyceridemia (HP:0002155)1.83157962
171Glomerulosclerosis (HP:0000096)1.83063663
172Gastrointestinal dysmotility (HP:0002579)1.83031723
173Abnormality of eosinophils (HP:0001879)1.82951106
174Hematochezia (HP:0002573)1.82829295
175Osteomalacia (HP:0002749)1.82259983
176Segmental peripheral demyelination/remyelination (HP:0003481)1.81183400
177Mucopolysacchariduria (HP:0008155)1.80606875
178Urinary glycosaminoglycan excretion (HP:0003541)1.80606875
179Ectopia lentis (HP:0001083)1.78892004
180Prominent nose (HP:0000448)1.78611781
181Bony spicule pigmentary retinopathy (HP:0007737)1.77841814
182Restlessness (HP:0000711)1.76224018
183Hyperparathyroidism (HP:0000843)1.74821512
184Rectal prolapse (HP:0002035)1.74208273
185Wide cranial sutures (HP:0010537)1.74126596
186Hepatoblastoma (HP:0002884)1.71893825
187Hyperammonemia (HP:0001987)1.71295699
188Abnormality of monocarboxylic acid metabolism (HP:0010996)1.71158578
189Hyperpituitarism (HP:0010514)1.69439929
190Hypoalphalipoproteinemia (HP:0003233)1.68443099
191Tubulointerstitial fibrosis (HP:0005576)1.67399750
192Increased CSF protein (HP:0002922)1.64471698
193Progressive neurologic deterioration (HP:0002344)1.63385663
194Abnormality of transition element cation homeostasis (HP:0011030)1.61713933
195Abnormal cartilage morphology (HP:0002763)1.59859285
196Hyperphosphatemia (HP:0002905)1.58456770
197Abnormality of the common coagulation pathway (HP:0010990)1.58324997

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNK24.77442552
2MAP4K13.92999942
3FER3.78822459
4MST43.74168650
5MAP4K23.66867113
6PKN23.18390563
7TESK23.13531283
8LMTK22.99216479
9ERN12.86122561
10LRRK22.59346153
11SIK12.46880837
12EPHB12.45704710
13TXK2.41108740
14TRIB32.25012102
15JAK32.22058940
16PDGFRA2.16284882
17FGFR22.12249208
18BLK2.01978949
19MAP3K131.96241047
20GRK61.95458956
21FGFR41.91808671
22SYK1.84678524
23STK391.83130003
24KIT1.77270759
25BTK1.62011822
26WNK41.61652887
27TBK11.60972624
28PTK61.59970789
29TAOK31.59925177
30CDC42BPA1.48950531
31GRK11.48303900
32MAP3K141.45811822
33MAP3K21.45045727
34IRAK41.43730957
35NTRK11.41621231
36EPHA21.38017547
37FRK1.35246249
38TYRO31.32738663
39FLT31.32559413
40IKBKE1.32219580
41PRKD31.29284216
42IRAK31.28680637
43RET1.27893541
44HCK1.26103446
45TTN1.21001513
46PTK21.20447914
47CSF1R1.15430658
48CDK191.14979842
49NTRK31.14682671
50STK101.11770935
51ZAP701.11126291
52LYN1.09943086
53INSR1.07788313
54MARK21.06187869
55TEC1.05561260
56LCK1.04576465
57PTK2B1.02897128
58PAK30.99243985
59EEF2K0.98962964
60FGFR30.98959844
61SCYL20.97048985
62MAP2K30.93403966
63RIPK40.93123085
64MYLK0.92924650
65ADRBK20.92181207
66BCKDK0.90107613
67KDR0.89121441
68MAP2K40.88423751
69MAP3K10.87723606
70TESK10.84768641
71CDK50.84239737
72MAP3K120.82390571
73MET0.82013457
74MAP3K30.81649011
75PRKCH0.81125599
76PAK20.80824317
77IKBKB0.80150192
78PRPF4B0.79647954
79LATS20.77145468
80PDK40.75400803
81PDK30.75400803
82EPHB20.75043165
83MARK30.73966473
84KSR20.72367469
85DMPK0.71998963
86CDK120.71051021
87PAK60.70359473
88MATK0.69719175
89MAPK120.69590147
90MAP3K100.66332701
91PAK40.66080522
92MAPK70.65542918
93MAP3K70.65350844
94MST1R0.64696031
95SIK20.64517454
96JAK20.63267389
97WNK10.62540977
98MAP2K20.62163537
99PIK3CG0.62062885
100ROCK20.61788194
101YES10.60934459
102ALK0.60404571
103PRKD20.60346007
104TAOK10.60232079
105INSRR0.59999134
106GSK3A0.59531573
107STK110.58482254
108PHKG20.58403388
109PHKG10.58403388
110CDK60.58058464
111MAPK110.57518531
112SRC0.57194561
113CHUK0.56490736
114FGFR10.56411238
115PIM10.54381338
116MAP3K110.54039612
117MAP2K10.53879227
118PDGFRB0.52377235
119ITK0.51973278
120ILK0.51636590
121BMPR20.51011059
122CSNK1E0.50422262
123LATS10.50289159
124ICK0.49780866
125PRKCG0.48942475
126PRKCZ0.48404940
127FYN0.47888285
128NLK0.47278185
129SIK30.47262623
130NTRK20.47241859
131PDK10.45551519
132MAP3K60.45504719
133PINK10.45060130
134PDK20.45050778
135PRKCQ0.44919880
136CDK40.44441072
137PASK0.44329062
138MAPKAPK20.44075475
139JAK10.43930898
140UHMK10.43761708
141DDR20.43275627
142PRKD10.43263190
143AKT30.41950055
144EPHA40.41594573
145PRKACG0.40494550
146MINK10.39292797
147EGFR0.38686805
148MAPK40.38380780
149CSK0.37956770
150CAMK1G0.37651532
151MAP3K50.37568580
152FES0.37433264
153TYK20.37056489
154ADRBK10.36666223
155PDPK10.36452140
156TRPM70.36355185
157IGF1R0.35761559
158ERBB20.35720168
159OBSCN0.35646835
160MAPK30.35010724
161DAPK20.32672159
162ABL10.31639019
163HIPK20.30969928
164ARAF0.30951657
165PRKCD0.30539159
166CAMK40.29564953
167RPS6KL10.27620838
168RPS6KC10.27620838

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.14011267
2Glutathione metabolism_Homo sapiens_hsa004804.36175260
3Primary immunodeficiency_Homo sapiens_hsa053404.22938760
4Autoimmune thyroid disease_Homo sapiens_hsa053203.76729817
5Allograft rejection_Homo sapiens_hsa053303.72956744
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.64806563
7Arachidonic acid metabolism_Homo sapiens_hsa005903.57962577
8Tryptophan metabolism_Homo sapiens_hsa003803.53604710
9Asthma_Homo sapiens_hsa053103.50774396
10Thyroid hormone synthesis_Homo sapiens_hsa049183.45561405
11Graft-versus-host disease_Homo sapiens_hsa053323.39068372
12African trypanosomiasis_Homo sapiens_hsa051433.32973903
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.06418208
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.96799271
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.72200479
16Type I diabetes mellitus_Homo sapiens_hsa049402.68871211
17B cell receptor signaling pathway_Homo sapiens_hsa046622.53330819
18Leishmaniasis_Homo sapiens_hsa051402.44410169
19Viral myocarditis_Homo sapiens_hsa054162.24606742
20Sulfur metabolism_Homo sapiens_hsa009202.21091263
21Antigen processing and presentation_Homo sapiens_hsa046122.19267219
22Fatty acid degradation_Homo sapiens_hsa000712.14523266
23Hematopoietic cell lineage_Homo sapiens_hsa046401.96043396
24Fatty acid metabolism_Homo sapiens_hsa012121.95659989
25Osteoclast differentiation_Homo sapiens_hsa043801.84834804
26Arginine biosynthesis_Homo sapiens_hsa002201.83216955
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.80564326
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.73034100
29Tuberculosis_Homo sapiens_hsa051521.65185795
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.63871852
31PPAR signaling pathway_Homo sapiens_hsa033201.59584232
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.57189422
33Toxoplasmosis_Homo sapiens_hsa051451.53742395
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.52441635
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52032297
36Herpes simplex infection_Homo sapiens_hsa051681.48610893
37Influenza A_Homo sapiens_hsa051641.45282505
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.37813660
39T cell receptor signaling pathway_Homo sapiens_hsa046601.37195290
40Rheumatoid arthritis_Homo sapiens_hsa053231.33888431
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.33749975
42Glycerolipid metabolism_Homo sapiens_hsa005611.29340842
43Salivary secretion_Homo sapiens_hsa049701.27314424
44Propanoate metabolism_Homo sapiens_hsa006401.25970747
45Malaria_Homo sapiens_hsa051441.23847593
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18260003
47Chemokine signaling pathway_Homo sapiens_hsa040621.16377299
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15903894
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13197674
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08440263
51Complement and coagulation cascades_Homo sapiens_hsa046101.07291292
52Acute myeloid leukemia_Homo sapiens_hsa052211.06574653
53Measles_Homo sapiens_hsa051621.06069501
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05748903
55Primary bile acid biosynthesis_Homo sapiens_hsa001201.04732941
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02448007
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.01449511
58Other glycan degradation_Homo sapiens_hsa005111.01384308
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.00775935
60Gastric acid secretion_Homo sapiens_hsa049710.98617865
61Platelet activation_Homo sapiens_hsa046110.96771442
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96617592
63Butanoate metabolism_Homo sapiens_hsa006500.96478793
64Lysosome_Homo sapiens_hsa041420.96445037
65Toll-like receptor signaling pathway_Homo sapiens_hsa046200.96040270
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.95441139
67Phototransduction_Homo sapiens_hsa047440.95304586
68Renin secretion_Homo sapiens_hsa049240.93990530
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.93580386
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.91708747
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90841914
72NOD-like receptor signaling pathway_Homo sapiens_hsa046210.90310584
73Bile secretion_Homo sapiens_hsa049760.90100488
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87487364
75beta-Alanine metabolism_Homo sapiens_hsa004100.87170997
76Fat digestion and absorption_Homo sapiens_hsa049750.86408443
77Starch and sucrose metabolism_Homo sapiens_hsa005000.83336455
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82703926
79Pyruvate metabolism_Homo sapiens_hsa006200.82208864
80Long-term potentiation_Homo sapiens_hsa047200.80987319
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80472785
82Phenylalanine metabolism_Homo sapiens_hsa003600.80233634
83Pertussis_Homo sapiens_hsa051330.79918303
84Estrogen signaling pathway_Homo sapiens_hsa049150.79288468
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78518155
86GABAergic synapse_Homo sapiens_hsa047270.78482882
87Epstein-Barr virus infection_Homo sapiens_hsa051690.75090245
88Vibrio cholerae infection_Homo sapiens_hsa051100.71262774
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.69686992
90Fatty acid biosynthesis_Homo sapiens_hsa000610.68399686
91Hepatitis C_Homo sapiens_hsa051600.67834694
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.63847942
93HTLV-I infection_Homo sapiens_hsa051660.63334174
94Fatty acid elongation_Homo sapiens_hsa000620.62460418
95Circadian entrainment_Homo sapiens_hsa047130.61927232
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61347891
97Collecting duct acid secretion_Homo sapiens_hsa049660.60804771
98Histidine metabolism_Homo sapiens_hsa003400.60457142
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59930868
100Arginine and proline metabolism_Homo sapiens_hsa003300.59904410
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58418942
102Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57470429
103Staphylococcus aureus infection_Homo sapiens_hsa051500.56872069
104Carbon metabolism_Homo sapiens_hsa012000.56098995
105Hepatitis B_Homo sapiens_hsa051610.55416934
106Prion diseases_Homo sapiens_hsa050200.54898436
107TNF signaling pathway_Homo sapiens_hsa046680.54778501
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54056505
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52193232
110Tyrosine metabolism_Homo sapiens_hsa003500.49708779
111Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48346664
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.47550009
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.47413622
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.47164686
115Inositol phosphate metabolism_Homo sapiens_hsa005620.46953711
116Amphetamine addiction_Homo sapiens_hsa050310.46377230
117Dilated cardiomyopathy_Homo sapiens_hsa054140.45026406
118Biosynthesis of amino acids_Homo sapiens_hsa012300.44600787
119Phagosome_Homo sapiens_hsa041450.44029573
120Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43371546
121Synaptic vesicle cycle_Homo sapiens_hsa047210.42818097
122Glutamatergic synapse_Homo sapiens_hsa047240.42236097
123Morphine addiction_Homo sapiens_hsa050320.41768015
124Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41425897
125Calcium signaling pathway_Homo sapiens_hsa040200.41344567
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.40774794
127Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40763561
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40703243
129Chemical carcinogenesis_Homo sapiens_hsa052040.40041726
130Non-small cell lung cancer_Homo sapiens_hsa052230.39937954
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38072832
132N-Glycan biosynthesis_Homo sapiens_hsa005100.37765325
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.37617015
134Folate biosynthesis_Homo sapiens_hsa007900.37408832
135Adipocytokine signaling pathway_Homo sapiens_hsa049200.36677242
136Peroxisome_Homo sapiens_hsa041460.36133055
137Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35740123
138Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.35088404
139Notch signaling pathway_Homo sapiens_hsa043300.35006673
140Glioma_Homo sapiens_hsa052140.33987464
141Apoptosis_Homo sapiens_hsa042100.33649805
142Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.33302601
143Choline metabolism in cancer_Homo sapiens_hsa052310.33224226
144Insulin secretion_Homo sapiens_hsa049110.33215279
145AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.33176387
146Melanogenesis_Homo sapiens_hsa049160.32756714
147Ovarian steroidogenesis_Homo sapiens_hsa049130.32462877
148Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31972028
149Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31737676
150mTOR signaling pathway_Homo sapiens_hsa041500.31275439
151cAMP signaling pathway_Homo sapiens_hsa040240.31207628
152Endocytosis_Homo sapiens_hsa041440.31154745
153GnRH signaling pathway_Homo sapiens_hsa049120.31129695
154Glucagon signaling pathway_Homo sapiens_hsa049220.29805690
155Systemic lupus erythematosus_Homo sapiens_hsa053220.29312742
156Insulin resistance_Homo sapiens_hsa049310.29269536
157Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29223265
158Dopaminergic synapse_Homo sapiens_hsa047280.28986232
159ABC transporters_Homo sapiens_hsa020100.28628881
160Prolactin signaling pathway_Homo sapiens_hsa049170.28581256
161Vitamin B6 metabolism_Homo sapiens_hsa007500.27160768
162VEGF signaling pathway_Homo sapiens_hsa043700.26302797
163Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.26090382
164Cysteine and methionine metabolism_Homo sapiens_hsa002700.25313566
165Cholinergic synapse_Homo sapiens_hsa047250.25068336
166Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.25050200
167MAPK signaling pathway_Homo sapiens_hsa040100.24790418
168Chronic myeloid leukemia_Homo sapiens_hsa052200.24141552
169Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.23822864
170Legionellosis_Homo sapiens_hsa051340.23418804
171Oxytocin signaling pathway_Homo sapiens_hsa049210.23413282
172cGMP-PKG signaling pathway_Homo sapiens_hsa040220.22186056
173Cocaine addiction_Homo sapiens_hsa050300.21617825

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