LCN12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the lipocalin family, such as LCN12, have a common structure consisting of an 8-stranded antiparallel beta-barrel that forms a cup-shaped ligand-binding pocket or calyx. Lipocalins generally bind small hydrophobic ligands and transport them to specific cells (Suzuki et al., 2004 [PubMed 15363845]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of T cell tolerance induction (GO:0002664)9.76564947
2kynurenine metabolic process (GO:0070189)9.31970503
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)8.97034740
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)8.97034740
5positive regulation of tolerance induction (GO:0002645)8.42899140
6antigen processing and presentation via MHC class Ib (GO:0002475)8.40377759
7indole-containing compound catabolic process (GO:0042436)7.77196930
8indolalkylamine catabolic process (GO:0046218)7.77196930
9tryptophan catabolic process (GO:0006569)7.77196930
10sperm capacitation (GO:0048240)7.48099813
11antigen processing and presentation of endogenous antigen (GO:0019883)7.40353257
12regulation of tolerance induction (GO:0002643)7.27862500
13regulation of antigen processing and presentation of peptide antigen (GO:0002583)7.27850529
14tryptophan metabolic process (GO:0006568)6.87817984
15aromatic amino acid family catabolic process (GO:0009074)6.09689144
16regulation of chronic inflammatory response (GO:0002676)6.08640916
17single fertilization (GO:0007338)5.63713804
18heterotypic cell-cell adhesion (GO:0034113)5.40642155
19sulfur amino acid catabolic process (GO:0000098)5.23279554
20negative regulation of interleukin-10 production (GO:0032693)5.10262174
21cellular biogenic amine catabolic process (GO:0042402)5.07471798
22amine catabolic process (GO:0009310)5.07471798
23indolalkylamine metabolic process (GO:0006586)5.03558603
24complement activation, alternative pathway (GO:0006957)5.03447454
25regulation of clathrin-mediated endocytosis (GO:2000369)4.94870686
26positive regulation of type 2 immune response (GO:0002830)4.93658570
27benzene-containing compound metabolic process (GO:0042537)4.92131540
28exogenous drug catabolic process (GO:0042738)4.60301067
29drug catabolic process (GO:0042737)4.56107031
30aromatic amino acid family metabolic process (GO:0009072)4.50954903
31fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.46257361
32fusion of sperm to egg plasma membrane (GO:0007342)4.34385475
33alpha-linolenic acid metabolic process (GO:0036109)4.33352273
34reverse cholesterol transport (GO:0043691)4.28529068
35negative regulation of endopeptidase activity (GO:0010951)4.27042740
36regulation of acrosome reaction (GO:0060046)4.25829440
37cysteine metabolic process (GO:0006534)4.15006891
38glyoxylate metabolic process (GO:0046487)4.09513667
39negative regulation of peptidase activity (GO:0010466)4.07833816
40cellular ketone body metabolic process (GO:0046950)4.05097637
41oxidative demethylation (GO:0070989)3.96385839
42valine metabolic process (GO:0006573)3.88911190
43L-phenylalanine catabolic process (GO:0006559)3.88320996
44erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.88320996
45high-density lipoprotein particle remodeling (GO:0034375)3.83848385
46phospholipid homeostasis (GO:0055091)3.79587658
47behavioral response to nicotine (GO:0035095)3.77783152
48negative regulation of translation, ncRNA-mediated (GO:0040033)3.76438014
49regulation of translation, ncRNA-mediated (GO:0045974)3.76438014
50negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.76438014
51digestion (GO:0007586)3.71377175
52fertilization (GO:0009566)3.67817695
53negative regulation of T cell apoptotic process (GO:0070233)3.67396295
54negative regulation of receptor-mediated endocytosis (GO:0048261)3.66755346
55S-adenosylmethionine metabolic process (GO:0046500)3.60655727
56indole-containing compound metabolic process (GO:0042430)3.56229412
57erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.55491993
58L-phenylalanine metabolic process (GO:0006558)3.55491993
59phenylpropanoid metabolic process (GO:0009698)3.53433288
60transepithelial transport (GO:0070633)3.52557063
61ketone body metabolic process (GO:1902224)3.51174874
62positive regulation of antigen processing and presentation (GO:0002579)3.46847710
63regulation of triglyceride catabolic process (GO:0010896)3.45629496
64epoxygenase P450 pathway (GO:0019373)3.43701935
65ethanol oxidation (GO:0006069)3.38086634
66regulation of protein activation cascade (GO:2000257)3.37943785
67regulation of fibrinolysis (GO:0051917)3.35849897
68alanine transport (GO:0032328)3.34068515
69regulation of complement activation (GO:0030449)3.33778917
70plasma membrane fusion (GO:0045026)3.31173553
71negative regulation of interleukin-8 production (GO:0032717)3.28259416
72negative regulation of protein autophosphorylation (GO:0031953)3.28220456
73imidazole-containing compound metabolic process (GO:0052803)3.24419035
74intestinal cholesterol absorption (GO:0030299)3.21834099
75cellular modified amino acid catabolic process (GO:0042219)3.21503219
76alpha-amino acid catabolic process (GO:1901606)3.19031914
77omega-hydroxylase P450 pathway (GO:0097267)3.14349726
78cellular amino acid catabolic process (GO:0009063)3.12535887
79protein-lipid complex remodeling (GO:0034368)3.07527844
80macromolecular complex remodeling (GO:0034367)3.07527844
81plasma lipoprotein particle remodeling (GO:0034369)3.07527844
82water-soluble vitamin biosynthetic process (GO:0042364)3.07519508
83negative regulation of sterol transport (GO:0032372)3.07201760
84negative regulation of cholesterol transport (GO:0032375)3.07201760
85peptidyl-glutamic acid carboxylation (GO:0017187)3.05016704
86protein carboxylation (GO:0018214)3.05016704
87cholesterol efflux (GO:0033344)3.03923747
88cytolysis (GO:0019835)3.01552338
89positive regulation of fatty acid transport (GO:2000193)2.98695317
90N-acetylneuraminate metabolic process (GO:0006054)2.96196423
91attachment of spindle microtubules to kinetochore (GO:0008608)2.95430172
92fatty acid transmembrane transport (GO:1902001)2.94653996
93acylglycerol homeostasis (GO:0055090)2.94112187
94triglyceride homeostasis (GO:0070328)2.94112187
95linoleic acid metabolic process (GO:0043651)2.92029969
96epithelial cell morphogenesis (GO:0003382)2.90665497
97drug metabolic process (GO:0017144)2.89743007
98response to misfolded protein (GO:0051788)2.89274965
99response to nitrosative stress (GO:0051409)2.87222738
100regulation of lipoprotein metabolic process (GO:0050746)2.86279888
101detection of light stimulus involved in sensory perception (GO:0050962)2.85918299
102detection of light stimulus involved in visual perception (GO:0050908)2.85918299
103positive regulation of cell-cell adhesion (GO:0022409)2.85680769
104positive regulation of cholesterol transport (GO:0032376)2.84970182
105positive regulation of sterol transport (GO:0032373)2.84970182
106detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.83860339
107regulation of cholesterol esterification (GO:0010872)2.82869894
108triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.79738721
109arginine catabolic process (GO:0006527)2.76525701
110amino-acid betaine metabolic process (GO:0006577)2.76146104
111complement activation, classical pathway (GO:0006958)2.75779929
112defense response to bacterium (GO:0042742)2.75364336
113negative regulation of proteolysis (GO:0045861)2.74958252
114bile acid biosynthetic process (GO:0006699)2.73070957
115positive regulation of icosanoid secretion (GO:0032305)2.72023166
116phospholipid efflux (GO:0033700)2.69809577
117serine family amino acid catabolic process (GO:0009071)2.68700795
118glycine metabolic process (GO:0006544)2.67724248
119homocysteine metabolic process (GO:0050667)2.67395183
120regulation of lipoprotein particle clearance (GO:0010984)2.67196532
121regulation of antigen processing and presentation (GO:0002577)2.66697134
122low-density lipoprotein particle clearance (GO:0034383)2.66292505
123coenzyme catabolic process (GO:0009109)2.66142366
124negative regulation of protein maturation (GO:1903318)2.66028601
125negative regulation of protein processing (GO:0010955)2.66028601
126complement activation (GO:0006956)2.64464282
127triglyceride catabolic process (GO:0019433)2.63802583
128negative regulation of lipase activity (GO:0060192)2.61513429
129acylglycerol catabolic process (GO:0046464)2.61288721
130neutral lipid catabolic process (GO:0046461)2.61288721
131organic acid catabolic process (GO:0016054)2.60238653
132carboxylic acid catabolic process (GO:0046395)2.60238653
133glutamate metabolic process (GO:0006536)2.60190073
134arginine metabolic process (GO:0006525)2.58530742
135positive regulation of lipoprotein lipase activity (GO:0051006)2.57364924
136positive regulation of triglyceride lipase activity (GO:0061365)2.57364924
137NAD biosynthetic process (GO:0009435)2.56780169
138pyrimidine ribonucleoside catabolic process (GO:0046133)2.56583951
139protein localization to cilium (GO:0061512)2.55129943
140macroautophagy (GO:0016236)2.54500033
141respiratory chain complex IV assembly (GO:0008535)2.53340001
142regulation of type 2 immune response (GO:0002828)2.52388271
143hormone catabolic process (GO:0042447)2.51858088
144regulation of cholesterol transport (GO:0032374)2.50929784
145regulation of sterol transport (GO:0032371)2.50929784
146negative regulation of protein activation cascade (GO:2000258)2.50625794
147plasma lipoprotein particle organization (GO:0071827)2.49722886
148serine family amino acid metabolic process (GO:0009069)2.46879238
149blood coagulation, intrinsic pathway (GO:0007597)2.46608142
150carnitine shuttle (GO:0006853)2.45554979
151C4-dicarboxylate transport (GO:0015740)2.45341568
152peptidyl-glutamic acid modification (GO:0018200)2.44373942
153piRNA metabolic process (GO:0034587)2.43860979
154cholesterol transport (GO:0030301)2.40838068
155sterol transport (GO:0015918)2.40838068
156branched-chain amino acid catabolic process (GO:0009083)2.40677226
157regulation of plasminogen activation (GO:0010755)2.40512368
158flavonoid metabolic process (GO:0009812)2.37285951
159thyroid hormone metabolic process (GO:0042403)2.37059989
160negative regulation of cytosolic calcium ion concentration (GO:0051481)2.37049259
161auditory receptor cell stereocilium organization (GO:0060088)2.35822821
162seminiferous tubule development (GO:0072520)16.8653093
163production of molecular mediator involved in inflammatory response (GO:0002532)10.1502678

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human6.09463552
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.15359363
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.28171891
4RXR_22158963_ChIP-Seq_LIVER_Mouse4.00356227
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.86341358
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.55988613
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.38350607
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.29523748
9ZNF274_21170338_ChIP-Seq_K562_Hela3.27502230
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.23698322
11VDR_22108803_ChIP-Seq_LS180_Human2.96334652
12AR_21572438_ChIP-Seq_LNCaP_Human2.94094978
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.87943412
14IGF1R_20145208_ChIP-Seq_DFB_Human2.76418645
15ZNF263_19887448_ChIP-Seq_K562_Human2.60077388
16RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.51462531
17GBX2_23144817_ChIP-Seq_PC3_Human2.43428021
18IKZF1_21737484_ChIP-ChIP_HCT116_Human2.37494844
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.26296518
20ESR2_21235772_ChIP-Seq_MCF-7_Human2.18254797
21FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.09285102
22CLOCK_20551151_ChIP-Seq_293T_Human2.02386707
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85755951
24BCAT_22108803_ChIP-Seq_LS180_Human1.84461068
25NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.83733623
26DNAJC2_21179169_ChIP-ChIP_NT2_Human1.83363639
27CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.78785201
28ER_23166858_ChIP-Seq_MCF-7_Human1.76528479
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.74991577
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74109381
31TRIM28_21343339_ChIP-Seq_HEK293_Human1.73132637
32TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.70093991
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64948556
34* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.61323665
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59204604
36STAT1_17558387_ChIP-Seq_HELA_Human1.57629101
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.49268337
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.48192771
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46966608
40GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.46269764
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44818243
42GATA3_21867929_ChIP-Seq_TH1_Mouse1.44200105
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41387792
44CBP_20019798_ChIP-Seq_JUKART_Human1.41387792
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39225290
46IRF8_22096565_ChIP-ChIP_GC-B_Human1.38879603
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38130463
48GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.37493703
49KLF5_20875108_ChIP-Seq_MESCs_Mouse1.36533192
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.36424156
51RAD21_21589869_ChIP-Seq_MESCs_Mouse1.35862630
52PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35806304
53P300_19829295_ChIP-Seq_ESCs_Human1.34750985
54ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34429827
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33834886
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.33834886
57* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33571761
58MYC_19915707_ChIP-ChIP_AK7_Human1.33088446
59CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32554985
60TET1_21451524_ChIP-Seq_MESCs_Mouse1.32005246
61SOX2_22085726_ChIP-Seq_NPCs_Mouse1.31504233
62CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.31272592
63PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.31238088
64ERA_21632823_ChIP-Seq_H3396_Human1.31133963
65TP53_22573176_ChIP-Seq_HFKS_Human1.30924727
66BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.30844744
67REST_21632747_ChIP-Seq_MESCs_Mouse1.30659708
68AR_25329375_ChIP-Seq_VCAP_Human1.30476622
69TCF4_22108803_ChIP-Seq_LS180_Human1.29167816
70NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.28836822
71EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.28408334
72MYC_19829295_ChIP-Seq_ESCs_Human1.27968051
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27831226
74SALL1_21062744_ChIP-ChIP_HESCs_Human1.27729792
75ETV2_25802403_ChIP-Seq_MESCs_Mouse1.25997425
76DROSHA_22980978_ChIP-Seq_HELA_Human1.24871978
77STAT3_23295773_ChIP-Seq_U87_Human1.24493179
78HOXB7_26014856_ChIP-Seq_BT474_Human1.23694057
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23505389
80SMAD4_21799915_ChIP-Seq_A2780_Human1.21700802
81AUTS2_25519132_ChIP-Seq_293T-REX_Human1.20567100
82NCOR_22424771_ChIP-Seq_293T_Human1.20105946
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20027173
84ELF1_20517297_ChIP-Seq_JURKAT_Human1.19596814
85TCF4_23295773_ChIP-Seq_U87_Human1.18869837
86SMAD4_21741376_ChIP-Seq_HESCs_Human1.18846093
87SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.18056811
88FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16803627
89EZH2_22144423_ChIP-Seq_EOC_Human1.16608422
90HTT_18923047_ChIP-ChIP_STHdh_Human1.15375890
91ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15323654
92SMAD1_18555785_Chip-Seq_ESCs_Mouse1.13391301
93CDX2_22108803_ChIP-Seq_LS180_Human1.13270307
94GATA3_21878914_ChIP-Seq_MCF-7_Human1.13178364
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11882926
96EWS_26573619_Chip-Seq_HEK293_Human1.11158511
97MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10621897
98STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10318173
99GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.10289966
100TAF15_26573619_Chip-Seq_HEK293_Human1.10081761
101FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06401539
102TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06317043
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06317043
104SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05616215
105SOX2_20726797_ChIP-Seq_SW620_Human1.05399832
106NANOG_19829295_ChIP-Seq_ESCs_Human1.05306211
107SOX2_19829295_ChIP-Seq_ESCs_Human1.05306211
108TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04770156
109JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.03709729
110AR_20517297_ChIP-Seq_VCAP_Human1.02711529
111STAT3_18555785_Chip-Seq_ESCs_Mouse1.01707554
112NFE2_27457419_Chip-Seq_LIVER_Mouse1.01591839
113AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00774122
114SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00537478
115VDR_24787735_ChIP-Seq_THP-1_Human0.99929976
116FOXH1_21741376_ChIP-Seq_EPCs_Human0.99416442
117* FLI1_21867929_ChIP-Seq_CD8_Mouse0.99292448
118SRF_21415370_ChIP-Seq_HL-1_Mouse0.98103477
119FOXH1_21741376_ChIP-Seq_ESCs_Human0.97336963
120* HNF4A_19822575_ChIP-Seq_HepG2_Human0.96884523
121CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96710301
122SMC4_20622854_ChIP-Seq_HELA_Human0.96686333
123* P53_21459846_ChIP-Seq_SAOS-2_Human0.96498299
124SMAD4_21741376_ChIP-Seq_EPCs_Human0.96414970
125FOXA2_19822575_ChIP-Seq_HepG2_Human0.96219775
126BCOR_27268052_Chip-Seq_Bcells_Human0.96218600
127MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96067489
128FUS_26573619_Chip-Seq_HEK293_Human0.95493721
129ESRRB_18555785_Chip-Seq_ESCs_Mouse0.95169119
130ESR1_20079471_ChIP-ChIP_T-47D_Human0.95152464
131LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.94971167
132TAF2_19829295_ChIP-Seq_ESCs_Human0.94881119
133RUNX2_22187159_ChIP-Seq_PCA_Human0.94208931
134CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94112882
135MYC_27129775_Chip-Seq_CORNEA_Mouse0.94108056
136ELK4_26923725_Chip-Seq_MESODERM_Mouse0.93471164
137* P68_20966046_ChIP-Seq_HELA_Human0.93202431
138EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92872342
139PCGF2_27294783_Chip-Seq_ESCs_Mouse0.92725393
140BCL6_27268052_Chip-Seq_Bcells_Human0.92725004
141FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92504367
142OCT4_20526341_ChIP-Seq_ESCs_Human0.92386057
143SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.92029805
144REST_19997604_ChIP-ChIP_NEURONS_Mouse0.91651479
145CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.91384755
146SOX9_24532713_ChIP-Seq_HFSC_Mouse0.91281118
147EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91247661
148* CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90997649
149* LXR_22292898_ChIP-Seq_THP-1_Human0.90992320
150EZH2_27294783_Chip-Seq_ESCs_Mouse0.89905925
151REST_18959480_ChIP-ChIP_MESCs_Mouse0.89501588
152SMAD3_21741376_ChIP-Seq_HESCs_Human0.89453701
153CSB_26484114_Chip-Seq_FIBROBLAST_Human0.89202339
154GATA1_19941826_ChIP-Seq_K562_Human0.89175486
155SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88213823
156EGR1_19032775_ChIP-ChIP_M12_Human0.87258823
157TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.87018059
158CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87012561
159RAC3_21632823_ChIP-Seq_H3396_Human0.86931698
160NR3C1_23031785_ChIP-Seq_PC12_Mouse0.86485290
161THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86306304
162TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.85648648
163BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85187802
164BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.84436138
165P300_27268052_Chip-Seq_Bcells_Human0.84411405
166EZH2_18974828_ChIP-Seq_MESCs_Mouse0.83568728
167RNF2_18974828_ChIP-Seq_MESCs_Mouse0.83568728
168NANOG_20526341_ChIP-Seq_ESCs_Human0.82375616
169RARB_24833708_ChIP-Seq_LIVER_Mouse0.82224437
170RXRA_24833708_ChIP-Seq_LIVER_Mouse0.82096604
171* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.82091891
172SALL4_22934838_ChIP-ChIP_CD34+_Human0.81890902
173ERG_21242973_ChIP-ChIP_JURKAT_Human0.81843934
174KDM2B_26808549_Chip-Seq_REH_Human0.81067512
175ZNF217_24962896_ChIP-Seq_MCF-7_Human0.80589163
176FOXO3_23340844_ChIP-Seq_DLD1_Human0.78275188
177E2F1_20622854_ChIP-Seq_HELA_Human0.76495624
178GATA3_21867929_ChIP-Seq_CD8_Mouse0.76082488
179RARA_24833708_ChIP-Seq_LIVER_Mouse0.73694696

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.24559609
2MP0003195_calcinosis4.58424846
3MP0010234_abnormal_vibrissa_follicle4.30970813
4MP0005360_urolithiasis4.04382130
5MP0005365_abnormal_bile_salt4.01012385
6MP0005058_abnormal_lysosome_morphology3.67224851
7MP0005085_abnormal_gallbladder_physiolo3.63821878
8MP0002254_reproductive_system_inflammat3.54191614
9MP0003303_peritoneal_inflammation3.22055467
10MP0004043_abnormal_pH_regulation2.91870731
11MP0010329_abnormal_lipoprotein_level2.91146156
12MP0006292_abnormal_olfactory_placode2.69786362
13MP0008875_abnormal_xenobiotic_pharmacok2.69222269
14MP0003787_abnormal_imprinting2.66669904
15MP0003252_abnormal_bile_duct2.53034735
16MP0005083_abnormal_biliary_tract2.49281563
17MP0003191_abnormal_cellular_cholesterol2.38798484
18MP0003806_abnormal_nucleotide_metabolis2.20945835
19MP0005551_abnormal_eye_electrophysiolog2.19289508
20MP0001666_abnormal_nutrient_absorption2.16821596
21MP0003300_gastrointestinal_ulcer2.15800221
22MP0005410_abnormal_fertilization2.13219498
23MP0005645_abnormal_hypothalamus_physiol1.94995169
24MP0005332_abnormal_amino_acid1.94734657
25MP0003011_delayed_dark_adaptation1.88491245
26MP0005646_abnormal_pituitary_gland1.88021858
27MP0008872_abnormal_physiological_respon1.86249430
28MP0002118_abnormal_lipid_homeostasis1.81578906
29MP0002909_abnormal_adrenal_gland1.78811157
30MP0002796_impaired_skin_barrier1.77141915
31MP0008877_abnormal_DNA_methylation1.71990468
32MP0003329_amyloid_beta_deposits1.64299247
33MP0001986_abnormal_taste_sensitivity1.63764781
34MP0003122_maternal_imprinting1.63172294
35MP0009643_abnormal_urine_homeostasis1.61663396
36MP0002138_abnormal_hepatobiliary_system1.60919675
37MP0001485_abnormal_pinna_reflex1.60272454
38MP0005275_abnormal_skin_tensile1.57307576
39MP0000604_amyloidosis1.54067130
40MP0008789_abnormal_olfactory_epithelium1.53347163
41MP0003705_abnormal_hypodermis_morpholog1.51981854
42MP0001968_abnormal_touch/_nociception1.51475892
43MP0000003_abnormal_adipose_tissue1.48427266
44MP0000609_abnormal_liver_physiology1.46945393
45MP0002168_other_aberrant_phenotype1.44757642
46MP0005584_abnormal_enzyme/coenzyme_acti1.44623147
47MP0004019_abnormal_vitamin_homeostasis1.44229595
48MP0003880_abnormal_central_pattern1.43452837
49MP0005636_abnormal_mineral_homeostasis1.42305540
50MP0002938_white_spotting1.42185999
51MP0001765_abnormal_ion_homeostasis1.39573106
52MP0003121_genomic_imprinting1.36579300
53MP0004130_abnormal_muscle_cell1.36456159
54MP0001502_abnormal_circadian_rhythm1.33782190
55MP0009840_abnormal_foam_cell1.33453953
56MP0005319_abnormal_enzyme/_coenzyme1.32395231
57MP0005253_abnormal_eye_physiology1.28718247
58MP0005379_endocrine/exocrine_gland_phen1.28224964
59MP0000566_synostosis1.28221363
60MP0005670_abnormal_white_adipose1.25005589
61MP0004133_heterotaxia1.24518876
62MP0002102_abnormal_ear_morphology1.22940828
63MP0009745_abnormal_behavioral_response1.20438330
64MP0005375_adipose_tissue_phenotype1.19928328
65MP0009046_muscle_twitch1.19771363
66MP0001853_heart_inflammation1.16895057
67MP0002876_abnormal_thyroid_physiology1.16444591
68MP0006072_abnormal_retinal_apoptosis1.16353343
69MP0002837_dystrophic_cardiac_calcinosis1.16210488
70MP0005423_abnormal_somatic_nervous1.15796118
71MP0000631_abnormal_neuroendocrine_gland1.10904952
72MP0001756_abnormal_urination1.08442030
73MP0009379_abnormal_foot_pigmentation1.08376390
74MP0002638_abnormal_pupillary_reflex1.08188935
75MP0001661_extended_life_span1.07909749
76MP0001529_abnormal_vocalization1.06913737
77MP0002653_abnormal_ependyma_morphology1.05818232
78MP0006276_abnormal_autonomic_nervous1.05218906
79MP0005451_abnormal_body_composition1.03531880
80MP0001764_abnormal_homeostasis1.01894664
81MP0002272_abnormal_nervous_system1.00941318
82MP0004147_increased_porphyrin_level1.00695315
83MP0000013_abnormal_adipose_tissue1.00403216
84MP0003690_abnormal_glial_cell1.00199961
85MP0009763_increased_sensitivity_to0.99867859
86MP0008438_abnormal_cutaneous_collagen0.99672112
87MP0004742_abnormal_vestibular_system0.99654504
88MP0005084_abnormal_gallbladder_morpholo0.97884474
89MP0003566_abnormal_cell_adhesion0.96721392
90MP0000639_abnormal_adrenal_gland0.96599519
91MP0001944_abnormal_pancreas_morphology0.95679101
92MP0008995_early_reproductive_senescence0.95497530
93MP0005666_abnormal_adipose_tissue0.95190389
94MP0002557_abnormal_social/conspecific_i0.94557189
95MP0001501_abnormal_sleep_pattern0.94499193
96MP0003718_maternal_effect0.94387416
97MP0002693_abnormal_pancreas_physiology0.94321978
98MP0010678_abnormal_skin_adnexa0.94285954
99MP0004145_abnormal_muscle_electrophysio0.93613030
100MP0004924_abnormal_behavior0.93531513
101MP0005386_behavior/neurological_phenoty0.93531513
102MP0004264_abnormal_extraembryonic_tissu0.93171417
103MP0000538_abnormal_urinary_bladder0.93075138
104MP0001486_abnormal_startle_reflex0.92041304
105MP0002736_abnormal_nociception_after0.91897391
106MP0002735_abnormal_chemical_nociception0.91315674
107MP0001984_abnormal_olfaction0.90775395
108MP0002064_seizures0.90399121
109MP0000681_abnormal_thyroid_gland0.89624525
110MP0004858_abnormal_nervous_system0.89587271
111MP0003656_abnormal_erythrocyte_physiolo0.88812384
112MP0005394_taste/olfaction_phenotype0.88146256
113MP0005499_abnormal_olfactory_system0.88146256
114MP0002136_abnormal_kidney_physiology0.88018578
115MP0005389_reproductive_system_phenotype0.87127846
116MP0005408_hypopigmentation0.87101018
117MP0004885_abnormal_endolymph0.85155982
118MP0004142_abnormal_muscle_tone0.84357945
119MP0003868_abnormal_feces_composition0.83167302
120MP0005334_abnormal_fat_pad0.82063189
121MP0009764_decreased_sensitivity_to0.81614955
122MP0001919_abnormal_reproductive_system0.81177709
123MP0004185_abnormal_adipocyte_glucose0.80683613
124MP0003075_altered_response_to0.80586530
125MP0002234_abnormal_pharynx_morphology0.80216929
126MP0001963_abnormal_hearing_physiology0.79034628
127MP0009384_cardiac_valve_regurgitation0.77637643
128MP0000026_abnormal_inner_ear0.76891697
129MP0008775_abnormal_heart_ventricle0.76258393
130MP0003938_abnormal_ear_development0.75449764
131MP0005220_abnormal_exocrine_pancreas0.75188694
132MP0003953_abnormal_hormone_level0.74736752
133MP0002067_abnormal_sensory_capabilities0.74632043
134MP0005448_abnormal_energy_balance0.74363420
135MP0005535_abnormal_body_temperature0.73875811
136MP0002928_abnormal_bile_duct0.73383181
137MP0002572_abnormal_emotion/affect_behav0.72966363
138MP0002229_neurodegeneration0.72746357
139MP0003878_abnormal_ear_physiology0.72539093
140MP0005377_hearing/vestibular/ear_phenot0.72539093
141MP0003638_abnormal_response/metabolism_0.72496645
142MP0000534_abnormal_ureter_morphology0.71914354
143MP0009765_abnormal_xenobiotic_induced0.71895752
144MP0002971_abnormal_brown_adipose0.71842540
145MP0000598_abnormal_liver_morphology0.71095798
146MP0003186_abnormal_redox_activity0.70328655
147MP0003959_abnormal_lean_body0.63259770
148MP0009642_abnormal_blood_homeostasis0.62323095
149MP0002295_abnormal_pulmonary_circulatio0.61097425
150MP0002078_abnormal_glucose_homeostasis0.60788103
151MP0005464_abnormal_platelet_physiology0.60563935
152MP0008469_abnormal_protein_level0.60189956
153MP0005395_other_phenotype0.59775979
154MP0003698_abnormal_male_reproductive0.59207433
155MP0000249_abnormal_blood_vessel0.58530509
156MP0003879_abnormal_hair_cell0.58183951
157MP0002166_altered_tumor_susceptibility0.56424421
158MP0003632_abnormal_nervous_system0.54750455
159MP0002896_abnormal_bone_mineralization0.54186073
160MP0005167_abnormal_blood-brain_barrier0.53937092
161MP0005501_abnormal_skin_physiology0.51244120
162MP0009780_abnormal_chondrocyte_physiolo0.51055835
163MP0004947_skin_inflammation0.51021329
164MP0005166_decreased_susceptibility_to0.50679035
165MP0002009_preneoplasia0.46276939
166MP0003631_nervous_system_phenotype0.44990837
167MP0001440_abnormal_grooming_behavior0.44852439
168MP0003633_abnormal_nervous_system0.44540181
169MP0010386_abnormal_urinary_bladder0.44088541

Predicted human phenotypes

RankGene SetZ-score
1Complement deficiency (HP:0004431)6.95471851
2Vascular calcification (HP:0004934)5.32585926
3Myocardial infarction (HP:0001658)5.17771969
4Abnormality of complement system (HP:0005339)5.01485823
5Cardiovascular calcification (HP:0011915)4.88013761
6Recurrent gram-negative bacterial infections (HP:0005420)4.70140117
7Hypophosphatemic rickets (HP:0004912)4.70128587
8Potter facies (HP:0002009)4.56991765
9Facial shape deformation (HP:0011334)4.56991765
10Choroideremia (HP:0001139)4.51580948
11Deep venous thrombosis (HP:0002625)4.39594336
12Vacuolated lymphocytes (HP:0001922)4.13538458
13Intrahepatic cholestasis (HP:0001406)4.06990198
14Abnormality of aromatic amino acid family metabolism (HP:0004338)3.85938461
15Xanthomatosis (HP:0000991)3.84452820
16Congenital stationary night blindness (HP:0007642)3.66322169
17Abnormality of the fovea (HP:0000493)3.56897163
18Abnormal rod and cone electroretinograms (HP:0008323)3.56217682
19Hypothermia (HP:0002045)3.45040839
20Hyperglycinuria (HP:0003108)3.32261618
21Malnutrition (HP:0004395)3.29343310
22Hyperglycinemia (HP:0002154)3.21176557
23True hermaphroditism (HP:0010459)3.17014646
24Ketosis (HP:0001946)3.15400868
25Abnormality of monocarboxylic acid metabolism (HP:0010996)3.11802163
26Pancreatic cysts (HP:0001737)3.11553005
27Rickets (HP:0002748)3.11409317
28Abnormality of serine family amino acid metabolism (HP:0010894)3.09852410
29Abnormality of glycine metabolism (HP:0010895)3.09852410
30Polydipsia (HP:0001959)3.04898126
31Abnormal drinking behavior (HP:0030082)3.04898126
32Intention tremor (HP:0002080)3.02731107
33Hyperlipoproteinemia (HP:0010980)3.01304595
34Hyperammonemia (HP:0001987)2.99814807
35Pancreatic fibrosis (HP:0100732)2.99149474
36Type II lissencephaly (HP:0007260)2.98371885
37Abnormality of sulfur amino acid metabolism (HP:0004339)2.97785720
38Ketoacidosis (HP:0001993)2.97590593
39Hypomagnesemia (HP:0002917)2.95169184
40Nephronophthisis (HP:0000090)2.94031864
41Neurofibrillary tangles (HP:0002185)2.91268534
42Tubulointerstitial fibrosis (HP:0005576)2.90461161
43Hypobetalipoproteinemia (HP:0003563)2.90399844
44Abnormality of midbrain morphology (HP:0002418)2.89871441
45Molar tooth sign on MRI (HP:0002419)2.89871441
46Bony spicule pigmentary retinopathy (HP:0007737)2.88797530
47Abnormality of the renal cortex (HP:0011035)2.85661723
48Infantile muscular hypotonia (HP:0008947)2.85257402
49Proximal tubulopathy (HP:0000114)2.82837517
50Abnormality of the common coagulation pathway (HP:0010990)2.77182218
51Epidermoid cyst (HP:0200040)2.72634036
52Cerebral inclusion bodies (HP:0100314)2.72455434
53Glomerulonephritis (HP:0000099)2.68699458
54Hyperventilation (HP:0002883)2.68230596
55Hypopigmentation of the fundus (HP:0007894)2.67891360
56Polyuria (HP:0000103)2.67709908
57Prolonged partial thromboplastin time (HP:0003645)2.63175931
58Abnormality of the renal medulla (HP:0100957)2.62593100
59Hemorrhage of the eye (HP:0011885)2.61067204
60Osteomalacia (HP:0002749)2.60757348
61Bile duct proliferation (HP:0001408)2.59500231
62Abnormal biliary tract physiology (HP:0012439)2.59500231
63Systemic lupus erythematosus (HP:0002725)2.59273713
64Skin nodule (HP:0200036)2.58842586
65Abnormality of purine metabolism (HP:0004352)2.56942138
66Thyroid-stimulating hormone excess (HP:0002925)2.55323750
67Congenital sensorineural hearing impairment (HP:0008527)2.53971985
68Cystic liver disease (HP:0006706)2.52263503
69Polar cataract (HP:0010696)2.50837580
70Agitation (HP:0000713)2.49266546
71Hypercholesterolemia (HP:0003124)2.48633495
72Renal cortical cysts (HP:0000803)2.47040914
73Tetany (HP:0001281)2.44790691
74Abnormal urine output (HP:0012590)2.43841190
75Attenuation of retinal blood vessels (HP:0007843)2.42888271
76Absent rod-and cone-mediated responses on ERG (HP:0007688)2.42168866
77Hypolipoproteinemia (HP:0010981)2.40418700
78Gout (HP:0001997)2.39646101
79Hypoalphalipoproteinemia (HP:0003233)2.34051658
80Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.33384797
81Delayed CNS myelination (HP:0002188)2.30551889
82Focal segmental glomerulosclerosis (HP:0000097)2.26468484
83Acanthosis nigricans (HP:0000956)2.25824385
84Abnormality of macular pigmentation (HP:0008002)2.25408355
85Abolished electroretinogram (ERG) (HP:0000550)2.23412308
86Increased circulating renin level (HP:0000848)2.21076760
87Esophageal varix (HP:0002040)2.20611423
88Dysostosis multiplex (HP:0000943)2.19419451
89Glomerulosclerosis (HP:0000096)2.19039338
90Abnormality of dicarboxylic acid metabolism (HP:0010995)2.18674369
91Dicarboxylic aciduria (HP:0003215)2.18674369
92Spontaneous abortion (HP:0005268)2.18187699
93Hypoglycemic coma (HP:0001325)2.17826564
94Hyperphosphatemia (HP:0002905)2.17794909
95Spastic diplegia (HP:0001264)2.17698313
96Abnormal hemoglobin (HP:0011902)2.17410079
97Conjugated hyperbilirubinemia (HP:0002908)2.16791313
98Abnormality of renal excretion (HP:0011036)2.15357399
99Abnormality of the intrinsic pathway (HP:0010989)2.14203328
100Congenital ichthyosiform erythroderma (HP:0007431)2.13173748
101Hypertriglyceridemia (HP:0002155)2.11891889
102Fat malabsorption (HP:0002630)2.11636352
103Abnormality of glutamine family amino acid metabolism (HP:0010902)2.10869198
104Abnormality of magnesium homeostasis (HP:0004921)2.10787583
105Abnormality of nucleobase metabolism (HP:0010932)2.10303267
106Ectopia lentis (HP:0001083)2.09242505
107Disproportionate short-trunk short stature (HP:0003521)2.08982952
108Hepatic necrosis (HP:0002605)2.07410057
109Cerebellar dysplasia (HP:0007033)2.06663663
110Amyloidosis (HP:0011034)2.04531221
111Central scotoma (HP:0000603)2.03087037
112Male pseudohermaphroditism (HP:0000037)2.02681177
113Cone-rod dystrophy (HP:0000548)2.01956173
114Thin bony cortex (HP:0002753)2.01570572
115Severe muscular hypotonia (HP:0006829)2.01561819
116Metaphyseal cupping (HP:0003021)2.00615427
117Hydroxyprolinuria (HP:0003080)2.00192622
118Abnormality of proline metabolism (HP:0010907)2.00192622
119Choreoathetosis (HP:0001266)1.97854273
120Hemiplegia (HP:0002301)1.97202259
121Widely patent fontanelles and sutures (HP:0004492)1.97129940
122Febrile seizures (HP:0002373)1.96368362
123Degeneration of the lateral corticospinal tracts (HP:0002314)1.96313279
124Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.96313279
125Gaze-evoked nystagmus (HP:0000640)1.95254817
126Keratoconus (HP:0000563)1.94396162
127Increased corneal curvature (HP:0100692)1.94396162
128Hypophosphatemia (HP:0002148)1.94169477
129Methylmalonic aciduria (HP:0012120)1.92952605
130Methylmalonic acidemia (HP:0002912)1.92735379
131Pancreatitis (HP:0001733)1.90836448
132Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.90348450
133Abnormality of alanine metabolism (HP:0010916)1.90348450
134Hyperalaninemia (HP:0003348)1.90348450
135Mesangial abnormality (HP:0001966)1.89449048
136Nonprogressive disorder (HP:0003680)1.89041725
137Increased IgE level (HP:0003212)1.88617721
138Abnormality of fatty-acid metabolism (HP:0004359)1.88496698
139Nephritis (HP:0000123)1.87699858
140Chronic hepatic failure (HP:0100626)1.87577694
141Joint hemorrhage (HP:0005261)1.86340196
142Thyroiditis (HP:0100646)1.85955716
143Macular degeneration (HP:0000608)1.84014219
144Neoplasm of the heart (HP:0100544)1.83992427
145Action tremor (HP:0002345)1.83289294
146Back pain (HP:0003418)1.83205656
147Hemiparesis (HP:0001269)1.82972653
148Supranuclear gaze palsy (HP:0000605)1.82029478
149Tachypnea (HP:0002789)1.80431947
150Decreased central vision (HP:0007663)1.80416539
151Hyperbilirubinemia (HP:0002904)1.79493368
152Abnormality of urine glucose concentration (HP:0011016)1.78522139
153Glycosuria (HP:0003076)1.78522139
154Right ventricular cardiomyopathy (HP:0011663)1.78343185
155Stomach cancer (HP:0012126)1.77853329
156Broad-based gait (HP:0002136)1.77200213
157Rib fusion (HP:0000902)1.77108402
158Generalized aminoaciduria (HP:0002909)1.77076941
159Dialeptic seizures (HP:0011146)1.76178080
160Metabolic acidosis (HP:0001942)1.75770637
161Hepatocellular necrosis (HP:0001404)1.75769755
162Goiter (HP:0000853)1.73748706
163Abnormality of the Achilles tendon (HP:0005109)1.72652439
164Tubular atrophy (HP:0000092)1.72643259
1653-Methylglutaconic aciduria (HP:0003535)1.71577966
166Restlessness (HP:0000711)1.71339830
167Abnormality of transition element cation homeostasis (HP:0011030)1.70829218
168Sclerocornea (HP:0000647)1.70557634
169Abnormality of glycosaminoglycan metabolism (HP:0004371)1.70411715
170Abnormality of mucopolysaccharide metabolism (HP:0011020)1.70411715
171Abnormality of polysaccharide metabolism (HP:0011012)1.70411715
172Congenital hepatic fibrosis (HP:0002612)1.70331068
173Subcapsular cataract (HP:0000523)1.70010965
174Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.67861366
175Abnormal enzyme/coenzyme activity (HP:0012379)1.66471747

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.03356139
2MST43.63446612
3TAOK33.51199601
4SIK13.48693157
5MUSK3.22659801
6BMPR1B3.12258713
7NUAK13.01809501
8BCKDK2.82899406
9PKN22.78286952
10NEK12.69018888
11PINK12.68800665
12WNK32.57559743
13EPHB12.56182479
14CASK2.52878509
15LMTK22.38750233
16TRIB32.36376129
17ACVR1B2.35090227
18FGFR42.32878020
19GRK12.30131378
20NTRK32.15208028
21LRRK22.10241524
22FRK2.01089601
23ADRBK22.00978294
24MAP2K41.96021735
25STK391.95090218
26MAPK131.85832020
27FER1.85593626
28TLK11.85086654
29FGFR21.82360291
30MYLK1.81326438
31WNK41.79479221
32MAP4K21.78989244
33AKT31.72086275
34OXSR11.71114441
35INSRR1.64665293
36ZAK1.61686765
37MAP2K61.56335520
38PTK61.52997724
39PDGFRA1.52012270
40MAP3K21.48438597
41VRK21.43491904
42RET1.40391128
43IRAK11.38982278
44TNK21.37561256
45MAP3K61.37427422
46FLT31.33575559
47NME11.28021098
48TTN1.25099837
49PHKG11.19615274
50TGFBR21.16919919
51EEF2K1.16151692
52PTK21.14535002
53LATS11.07214009
54PRKCE1.02640998
55PAK21.00498508
56STK100.97671496
57EPHA40.96963361
58PTK2B0.96898340
59MAP3K70.96787502
60JAK20.92055726
61JAK10.90831138
62STK160.90573799
63PRKCI0.89385233
64GRK50.89315075
65PAK30.88361214
66TGFBR10.88222950
67SIK20.87571346
68PRKD30.85309275
69PDK20.83718560
70RIPK40.82154084
71CAMKK20.79400040
72TEC0.77183400
73MAP2K30.76784900
74PRKCH0.76155224
75INSR0.72845609
76IKBKB0.72725641
77FGFR30.72072577
78CAMK1D0.71898545
79ERBB20.70470525
80DYRK20.69340727
81TESK10.68972049
82MST1R0.67890588
83MAP3K40.67026048
84MAP2K20.66674343
85PIK3CG0.65996185
86PRKAA10.65926790
87MAP4K10.65463163
88PRKAA20.65221557
89TXK0.65182480
90MAP2K70.64152196
91DYRK1B0.63421213
92TYRO30.63161132
93PKN10.62985742
94EPHA20.62653644
95IRAK30.62360200
96EGFR0.62186243
97MATK0.62060538
98RIPK10.62060537
99DAPK20.61470901
100GRK60.59138977
101MAP2K10.57917739
102DMPK0.56947926
103PRKCZ0.56469807
104STK30.55204073
105HIPK20.55071590
106PRKACA0.54260135
107MARK10.53762884
108PLK20.53682017
109CAMK10.52183591
110CAMK1G0.52002219
111CDK60.51682964
112CSF1R0.51224503
113SRC0.51124033
114VRK10.50324129
115EPHA30.50028767
116STK38L0.49455666
117GSK3A0.49192372
118TIE10.49069665
119PRKD20.48787563
120MAPK120.48427503
121TBK10.47779088
122CDK190.47621215
123NTRK10.47514895
124ERBB40.47114213
125SGK20.46837169
126NTRK20.45968802
127SYK0.45863214
128NEK20.44903437
129PRKACG0.44647779
130FYN0.44258487
131MAP3K30.43967136
132IGF1R0.43873032
133PDGFRB0.43203374
134TYK20.43005770
135KIT0.42968633
136ADRBK10.42635310
137SGK10.42142592
138MET0.42030164
139ITK0.41754283
140FES0.41131014
141MAPKAPK30.40715288
142PRKCA0.40644254
143PRKCQ0.40167913
144PIK3CA0.39613143
145MAPK150.39135718
146PLK40.38848764
147MKNK20.38810911
148STK380.38401012
149BMX0.37309171
150CSK0.37146305
151PRKACB0.37081748
152CHUK0.37037683
153CCNB10.37032812
154PRKCG0.36542575
155DYRK1A0.36508460
156SGK4940.36405101
157SGK2230.36405101
158EPHB20.36387011
159PDK10.35187887
160LATS20.35084331
161DDR20.34931301
162WNK10.33983623
163PHKG20.33352517
164RPS6KA30.32883163
165CSNK1A10.31613439
166NLK0.30611986
167CAMK2D0.29293654

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.58689169
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.53510514
3Tryptophan metabolism_Homo sapiens_hsa003803.26219247
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.07450590
5Glutathione metabolism_Homo sapiens_hsa004803.03619143
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.68796791
7Fatty acid degradation_Homo sapiens_hsa000712.62549023
8Arachidonic acid metabolism_Homo sapiens_hsa005902.43168615
9Sulfur metabolism_Homo sapiens_hsa009202.41694198
10Arginine biosynthesis_Homo sapiens_hsa002202.32467953
11Fatty acid metabolism_Homo sapiens_hsa012122.29286573
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.21594194
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.18549364
14Thyroid hormone synthesis_Homo sapiens_hsa049182.04084951
15PPAR signaling pathway_Homo sapiens_hsa033202.02512221
16Complement and coagulation cascades_Homo sapiens_hsa046101.97829441
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.94082469
18African trypanosomiasis_Homo sapiens_hsa051431.93328641
19ABC transporters_Homo sapiens_hsa020101.83392053
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.74021802
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.71818614
22Glycerolipid metabolism_Homo sapiens_hsa005611.63182057
23Propanoate metabolism_Homo sapiens_hsa006401.63033070
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.52557910
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.51713435
26One carbon pool by folate_Homo sapiens_hsa006701.51137389
27Phototransduction_Homo sapiens_hsa047441.49214372
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.48218936
29Fat digestion and absorption_Homo sapiens_hsa049751.47888070
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.46111028
31Butanoate metabolism_Homo sapiens_hsa006501.35996944
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.32726729
33beta-Alanine metabolism_Homo sapiens_hsa004101.29034489
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.28380654
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.27390127
36Chemical carcinogenesis_Homo sapiens_hsa052041.25824414
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.24361942
38Peroxisome_Homo sapiens_hsa041461.23679181
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.23050499
40Ether lipid metabolism_Homo sapiens_hsa005651.21579516
41Staphylococcus aureus infection_Homo sapiens_hsa051501.14744187
42Phenylalanine metabolism_Homo sapiens_hsa003601.12479168
43Pyruvate metabolism_Homo sapiens_hsa006201.12466224
44Starch and sucrose metabolism_Homo sapiens_hsa005001.09931971
45Histidine metabolism_Homo sapiens_hsa003401.08730052
46Tyrosine metabolism_Homo sapiens_hsa003501.04621449
47Bile secretion_Homo sapiens_hsa049761.04593569
48Fatty acid elongation_Homo sapiens_hsa000621.02135879
49Protein export_Homo sapiens_hsa030600.97842442
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96397082
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95682035
52Biosynthesis of amino acids_Homo sapiens_hsa012300.89598106
53Selenocompound metabolism_Homo sapiens_hsa004500.88088583
54Homologous recombination_Homo sapiens_hsa034400.88041012
55Folate biosynthesis_Homo sapiens_hsa007900.87748036
56Intestinal immune network for IgA production_Homo sapiens_hsa046720.86299433
57Other glycan degradation_Homo sapiens_hsa005110.86279033
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.86199876
59Carbon metabolism_Homo sapiens_hsa012000.86188187
60Fatty acid biosynthesis_Homo sapiens_hsa000610.84214724
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83776077
62Circadian rhythm_Homo sapiens_hsa047100.82980365
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80194390
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.80129693
65Caffeine metabolism_Homo sapiens_hsa002320.79930364
66Insulin secretion_Homo sapiens_hsa049110.79886465
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78569229
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.78173940
69Salivary secretion_Homo sapiens_hsa049700.77447663
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77311173
71Prion diseases_Homo sapiens_hsa050200.76633428
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74616052
73RNA polymerase_Homo sapiens_hsa030200.74568217
74Lysosome_Homo sapiens_hsa041420.73874686
75Arginine and proline metabolism_Homo sapiens_hsa003300.73021965
76Oxidative phosphorylation_Homo sapiens_hsa001900.72576292
77Vitamin B6 metabolism_Homo sapiens_hsa007500.71894171
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69519750
79Fanconi anemia pathway_Homo sapiens_hsa034600.65134829
80Taste transduction_Homo sapiens_hsa047420.63520781
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.60828804
82Olfactory transduction_Homo sapiens_hsa047400.60814401
83Asthma_Homo sapiens_hsa053100.59409276
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58615924
85Type I diabetes mellitus_Homo sapiens_hsa049400.57971211
86Nicotine addiction_Homo sapiens_hsa050330.55396706
87Retinol metabolism_Homo sapiens_hsa008300.54761835
88Glutamatergic synapse_Homo sapiens_hsa047240.53013771
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.52460273
90Mineral absorption_Homo sapiens_hsa049780.52160469
91Vitamin digestion and absorption_Homo sapiens_hsa049770.49202945
92Serotonergic synapse_Homo sapiens_hsa047260.46936834
93Regulation of autophagy_Homo sapiens_hsa041400.46352961
94Pancreatic secretion_Homo sapiens_hsa049720.46043013
95Circadian entrainment_Homo sapiens_hsa047130.45142226
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42464105
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.41917427
98Parkinsons disease_Homo sapiens_hsa050120.41665555
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41327906
100Steroid biosynthesis_Homo sapiens_hsa001000.40867669
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38795587
102Renin secretion_Homo sapiens_hsa049240.38757440
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38584930
104Protein digestion and absorption_Homo sapiens_hsa049740.38037544
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37751774
106RNA degradation_Homo sapiens_hsa030180.35802046
107Morphine addiction_Homo sapiens_hsa050320.34969531
108Amphetamine addiction_Homo sapiens_hsa050310.31881403
109Autoimmune thyroid disease_Homo sapiens_hsa053200.31863403
110Gastric acid secretion_Homo sapiens_hsa049710.31538573
111Basal transcription factors_Homo sapiens_hsa030220.30824084
112Insulin resistance_Homo sapiens_hsa049310.26975502
113Metabolic pathways_Homo sapiens_hsa011000.25665291
114N-Glycan biosynthesis_Homo sapiens_hsa005100.23744332
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.21047377
116Vibrio cholerae infection_Homo sapiens_hsa051100.20442873
117Lysine degradation_Homo sapiens_hsa003100.19610245
118Leukocyte transendothelial migration_Homo sapiens_hsa046700.16250056
119Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.15941568
120Maturity onset diabetes of the young_Homo sapiens_hsa049500.15621687
121Renin-angiotensin system_Homo sapiens_hsa046140.15297330
122Estrogen signaling pathway_Homo sapiens_hsa049150.15279824
123Collecting duct acid secretion_Homo sapiens_hsa049660.15212614
124Linoleic acid metabolism_Homo sapiens_hsa005910.15113527
125Pentose phosphate pathway_Homo sapiens_hsa000300.13534868
126Aldosterone synthesis and secretion_Homo sapiens_hsa049250.12667772
127GABAergic synapse_Homo sapiens_hsa047270.11079788
128Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.10132133
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.08219537
130AMPK signaling pathway_Homo sapiens_hsa041520.07863263
131Glucagon signaling pathway_Homo sapiens_hsa049220.07560457
132Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.07325511
133Ovarian steroidogenesis_Homo sapiens_hsa049130.06321341

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