ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	indole-containing compound catabolic process (GO:0042436)	4.86976521
2	indolalkylamine catabolic process (GO:0046218)	4.86976521
3	tryptophan catabolic process (GO:0006569)	4.86976521
4	indolalkylamine metabolic process (GO:0006586)	4.75004955
5	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.52709651
6	tryptophan metabolic process (GO:0006568)	4.34365923
7	kynurenine metabolic process (GO:0070189)	4.29057843
8	behavioral response to nicotine (GO:0035095)	4.28800328
9	L-fucose catabolic process (GO:0042355)	4.07822426
10	fucose catabolic process (GO:0019317)	4.07822426
11	L-fucose metabolic process (GO:0042354)	4.07822426
12	photoreceptor cell maintenance (GO:0045494)	3.92713140
13	detection of light stimulus involved in visual perception (GO:0050908)	3.68438943
14	detection of light stimulus involved in sensory perception (GO:0050962)	3.68438943
15	cellular ketone body metabolic process (GO:0046950)	3.66148991
16	DNA deamination (GO:0045006)	3.56653068
17	NAD biosynthetic process (GO:0009435)	3.54201241
18	amine catabolic process (GO:0009310)	3.52852583
19	cellular biogenic amine catabolic process (GO:0042402)	3.52852583
20	indole-containing compound metabolic process (GO:0042430)	3.40943876
21	behavioral response to ethanol (GO:0048149)	3.40618550
22	neural tube formation (GO:0001841)	3.34375894
23	negative regulation of mast cell activation (GO:0033004)	3.31957681
24	auditory receptor cell stereocilium organization (GO:0060088)	3.31220163
25	ketone body metabolic process (GO:1902224)	3.27231181
26	centriole replication (GO:0007099)	3.25535398
27	regulation of meiosis I (GO:0060631)	3.22579596
28	axoneme assembly (GO:0035082)	3.22005978
29	replication fork processing (GO:0031297)	3.20189033
30	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.16002648
31	aromatic amino acid family catabolic process (GO:0009074)	3.13708688
32	mannosylation (GO:0097502)	3.10105615
33	platelet dense granule organization (GO:0060155)	3.06081124
34	piRNA metabolic process (GO:0034587)	3.04885808
35	signal peptide processing (GO:0006465)	3.04746675
36	cilium or flagellum-dependent cell motility (GO:0001539)	3.03630658
37	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.99353848
38	protein K11-linked deubiquitination (GO:0035871)	2.97886646
39	respiratory chain complex IV assembly (GO:0008535)	2.97784444
40	reciprocal DNA recombination (GO:0035825)	2.97309458
41	reciprocal meiotic recombination (GO:0007131)	2.97309458
42	protein complex biogenesis (GO:0070271)	2.95989031
43	DNA methylation involved in gamete generation (GO:0043046)	2.93083871
44	water-soluble vitamin biosynthetic process (GO:0042364)	2.91647179
45	sulfation (GO:0051923)	2.90821901
46	tachykinin receptor signaling pathway (GO:0007217)	2.90422617
47	aromatic amino acid family metabolic process (GO:0009072)	2.88174583
48	reflex (GO:0060004)	2.86922839
49	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.86741172
50	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.86741172
51	NADH dehydrogenase complex assembly (GO:0010257)	2.86741172
52	response to pheromone (GO:0019236)	2.82984101
53	retinal cone cell development (GO:0046549)	2.82976983
54	primary amino compound metabolic process (GO:1901160)	2.81165150
55	preassembly of GPI anchor in ER membrane (GO:0016254)	2.80195950
56	adenosine metabolic process (GO:0046085)	2.79654357
57	protein polyglutamylation (GO:0018095)	2.78836991
58	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.75796404
59	regulation of hippo signaling (GO:0035330)	2.75734295
60	mitochondrial respiratory chain complex assembly (GO:0033108)	2.75714080
61	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.74506372
62	benzene-containing compound metabolic process (GO:0042537)	2.72378647
63	cytochrome complex assembly (GO:0017004)	2.69678748
64	nonmotile primary cilium assembly (GO:0035058)	2.67781787
65	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.67335526
66	positive regulation of prostaglandin secretion (GO:0032308)	2.67302836
67	regulation of memory T cell differentiation (GO:0043380)	2.67186144
68	double-strand break repair via homologous recombination (GO:0000724)	2.67178483
69	DNA integration (GO:0015074)	2.66685497
70	protein-cofactor linkage (GO:0018065)	2.65856700
71	recombinational repair (GO:0000725)	2.64893478
72	L-methionine salvage (GO:0071267)	2.64525209
73	L-methionine biosynthetic process (GO:0071265)	2.64525209
74	amino acid salvage (GO:0043102)	2.64525209
75	drug catabolic process (GO:0042737)	2.60572412
76	epithelial cilium movement (GO:0003351)	2.60382591
77	arginine catabolic process (GO:0006527)	2.59746365
78	prenylation (GO:0097354)	2.59449881
79	protein prenylation (GO:0018342)	2.59449881
80	regulation of cilium movement (GO:0003352)	2.59097620
81	rhodopsin mediated signaling pathway (GO:0016056)	2.58942459
82	branched-chain amino acid catabolic process (GO:0009083)	2.57460346
83	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.56371832
84	phasic smooth muscle contraction (GO:0014821)	2.54935406
85	neuronal action potential (GO:0019228)	2.54839550
86	multicellular organism reproduction (GO:0032504)	2.54087318
87	serotonin metabolic process (GO:0042428)	2.52440708
88	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.51812667
89	transepithelial transport (GO:0070633)	2.51225373
90	inner ear receptor stereocilium organization (GO:0060122)	2.49684175
91	positive regulation of fatty acid transport (GO:2000193)	2.48335918
92	regulation of glucokinase activity (GO:0033131)	2.48296912
93	regulation of hexokinase activity (GO:1903299)	2.48296912
94	rRNA catabolic process (GO:0016075)	2.47569989
95	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.47282792
96	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.47282792
97	photoreceptor cell development (GO:0042461)	2.46038989
98	cilium organization (GO:0044782)	2.45730967
99	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.44895550
100	negative regulation of telomere maintenance (GO:0032205)	2.44173151

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.74616338
2	VDR_22108803_ChIP-Seq_LS180_Human	3.36312399
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.00179564
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.86405317
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.61504457
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.50789461
7	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.37284264
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.36671270
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.32381678
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.18305481
11	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.03557678
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.00185744
13	P300_19829295_ChIP-Seq_ESCs_Human	2.00129169
14	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.97803824
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.92902465
16	ER_23166858_ChIP-Seq_MCF-7_Human	1.92575562
17	EWS_26573619_Chip-Seq_HEK293_Human	1.90449225
18	FUS_26573619_Chip-Seq_HEK293_Human	1.89334176
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.88507207
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.86705647
21	TAF15_26573619_Chip-Seq_HEK293_Human	1.85982302
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.83774040
23	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.77913336
24	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.72162073
25	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.69198392
26	EZH2_22144423_ChIP-Seq_EOC_Human	1.69083424
27	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.69005864
28	TP53_22573176_ChIP-Seq_HFKS_Human	1.67970376
29	STAT3_23295773_ChIP-Seq_U87_Human	1.63923641
30	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.56569853
31	CBP_20019798_ChIP-Seq_JUKART_Human	1.56569853
32	BCAT_22108803_ChIP-Seq_LS180_Human	1.54056484
33	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.52745687
34	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.50845543
35	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.50225503
36	TCF4_23295773_ChIP-Seq_U87_Human	1.47556701
37	SMAD4_21799915_ChIP-Seq_A2780_Human	1.47418318
38	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.46874051
39	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.46752569
40	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.46752569
41	NANOG_19829295_ChIP-Seq_ESCs_Human	1.46206870
42	SOX2_19829295_ChIP-Seq_ESCs_Human	1.46206870
43	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.44165348
44	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.43815765
45	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.41845413
46	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.40385074
47	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.39781225
48	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.39781225
49	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.38187493
50	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.37080872
51	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.36616066
52	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.36305606
53	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.36296189
54	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.33291650
55	TCF4_22108803_ChIP-Seq_LS180_Human	1.31696243
56	AR_25329375_ChIP-Seq_VCAP_Human	1.31456148
57	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.31415320
58	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.31337342
59	IRF1_19129219_ChIP-ChIP_H3396_Human	1.30783615
60	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.30242109
61	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.29980578
62	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.29827166
63	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.28261978
64	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.27559333
65	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.26777142
66	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.26235214
67	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.24863491
68	AR_20517297_ChIP-Seq_VCAP_Human	1.21753570
69	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.19425104
70	NCOR_22424771_ChIP-Seq_293T_Human	1.19397121
71	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.18349194
72	CDX2_22108803_ChIP-Seq_LS180_Human	1.17311766
73	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.17144930
74	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.16509252
75	RUNX2_22187159_ChIP-Seq_PCA_Human	1.13234803
76	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.12696314
77	REST_21632747_ChIP-Seq_MESCs_Mouse	1.12561703
78	MYC_18940864_ChIP-ChIP_HL60_Human	1.12363221
79	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.11837979
80	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.11331683
81	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.10951341
82	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.10415248
83	AR_21572438_ChIP-Seq_LNCaP_Human	1.10196338
84	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.09747738
85	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.09488445
86	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.09240079
87	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.09007019
88	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.08728266
89	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.08077254
90	HOXB7_26014856_ChIP-Seq_BT474_Human	1.07752824
91	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.06696937
92	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.06398805
93	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.06255010
94	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.05703162
95	P53_22387025_ChIP-Seq_ESCs_Mouse	1.05673760
96	P300_18555785_Chip-Seq_ESCs_Mouse	1.01500324
97	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.00777471
98	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.99379519
99	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.97880220
100	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.97803287

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.44591520
2	MP0005645_abnormal_hypothalamus_physiol	3.30934333
3	MP0005551_abnormal_eye_electrophysiolog	2.71580335
4	MP0000372_irregular_coat_pigmentation	2.67849907
5	MP0004147_increased_porphyrin_level	2.66539034
6	MP0008877_abnormal_DNA_methylation	2.62260920
7	MP0000569_abnormal_digit_pigmentation	2.56988326
8	MP0003136_yellow_coat_color	2.33633092
9	MP0001968_abnormal_touch/_nociception	2.14104303
10	MP0005646_abnormal_pituitary_gland	2.13621965
11	MP0003646_muscle_fatigue	2.11547757
12	MP0008872_abnormal_physiological_respon	2.08957270
13	MP0002736_abnormal_nociception_after	2.07744286
14	MP0008875_abnormal_xenobiotic_pharmacok	2.00695377
15	MP0003787_abnormal_imprinting	1.93696487
16	MP0001501_abnormal_sleep_pattern	1.91144184
17	MP0004043_abnormal_pH_regulation	1.85239560
18	MP0002102_abnormal_ear_morphology	1.81119598
19	MP0002876_abnormal_thyroid_physiology	1.78566343
20	MP0009046_muscle_twitch	1.76566969
21	MP0005253_abnormal_eye_physiology	1.71711878
22	MP0004142_abnormal_muscle_tone	1.71439794
23	MP0003718_maternal_effect	1.65924954
24	MP0000427_abnormal_hair_cycle	1.65506966
25	MP0005174_abnormal_tail_pigmentation	1.63354392
26	MP0002938_white_spotting	1.63026588
27	MP0001986_abnormal_taste_sensitivity	1.62928990
28	MP0002638_abnormal_pupillary_reflex	1.62882454
29	MP0003950_abnormal_plasma_membrane	1.62062370
30	MP0002837_dystrophic_cardiac_calcinosis	1.58073036
31	MP0008058_abnormal_DNA_repair	1.57828560
32	MP0006072_abnormal_retinal_apoptosis	1.55489006
33	MP0005075_abnormal_melanosome_morpholog	1.54417423
34	MP0002653_abnormal_ependyma_morphology	1.53449017
35	MP0009745_abnormal_behavioral_response	1.51732993
36	MP0001984_abnormal_olfaction	1.44474559
37	MP0005085_abnormal_gallbladder_physiolo	1.42366648
38	MP0002735_abnormal_chemical_nociception	1.42199734
39	MP0005360_urolithiasis	1.42069815
40	MP0006276_abnormal_autonomic_nervous	1.42016757
41	MP0006292_abnormal_olfactory_placode	1.38569865
42	MP0001764_abnormal_homeostasis	1.37869641
43	MP0001485_abnormal_pinna_reflex	1.36589290
44	MP0005084_abnormal_gallbladder_morpholo	1.30253818
45	MP0003252_abnormal_bile_duct	1.29222318
46	MP0005167_abnormal_blood-brain_barrier	1.23507694
47	MP0000631_abnormal_neuroendocrine_gland	1.23296395
48	MP0005332_abnormal_amino_acid	1.22841810
49	MP0010386_abnormal_urinary_bladder	1.21816973
50	MP0001486_abnormal_startle_reflex	1.21262394
51	MP0000015_abnormal_ear_pigmentation	1.20500919
52	MP0002272_abnormal_nervous_system	1.17355848
53	MP0002733_abnormal_thermal_nociception	1.14162040
54	MP0005410_abnormal_fertilization	1.13430100
55	MP0010329_abnormal_lipoprotein_level	1.13422424
56	MP0003122_maternal_imprinting	1.12975644
57	MP0001529_abnormal_vocalization	1.09128316
58	MP0005171_absent_coat_pigmentation	1.08894273
59	MP0002557_abnormal_social/conspecific_i	1.08321930
60	MP0002160_abnormal_reproductive_system	1.07388669
61	MP0000383_abnormal_hair_follicle	1.06834036
62	MP0002095_abnormal_skin_pigmentation	1.05668408
63	MP0008995_early_reproductive_senescence	1.04583426
64	MP0005365_abnormal_bile_salt	1.03498704
65	MP0001970_abnormal_pain_threshold	1.02591412
66	MP0008057_abnormal_DNA_replication	1.02232973
67	MP0004742_abnormal_vestibular_system	1.00711086
68	MP0003880_abnormal_central_pattern	1.00305677
69	MP0001324_abnormal_eye_pigmentation	0.99823373
70	MP0000230_abnormal_systemic_arterial	0.98862109
71	MP0003698_abnormal_male_reproductive	0.97754756
72	MP0000538_abnormal_urinary_bladder	0.97179017
73	MP0002572_abnormal_emotion/affect_behav	0.96634043
74	MP0002928_abnormal_bile_duct	0.95486817
75	MP0005377_hearing/vestibular/ear_phenot	0.95478013
76	MP0003878_abnormal_ear_physiology	0.95478013
77	MP0002751_abnormal_autonomic_nervous	0.92801199
78	MP0002067_abnormal_sensory_capabilities	0.92170789
79	MP0005386_behavior/neurological_phenoty	0.91803226
80	MP0004924_abnormal_behavior	0.91803226
81	MP0005389_reproductive_system_phenotype	0.91713828
82	MP0002229_neurodegeneration	0.91091251
83	MP0002064_seizures	0.89954950
84	MP0003045_fibrosis	0.89605585
85	MP0003121_genomic_imprinting	0.88251840
86	MP0004145_abnormal_muscle_electrophysio	0.87949297
87	MP0002138_abnormal_hepatobiliary_system	0.87275813
88	MP0003011_delayed_dark_adaptation	0.85728323
89	MP0001929_abnormal_gametogenesis	0.85016203
90	MP0001664_abnormal_digestion	0.83906454
91	MP0003943_abnormal_hepatobiliary_system	0.83218743
92	MP0005647_abnormal_sex_gland	0.82113784
93	MP0003806_abnormal_nucleotide_metabolis	0.80617178
94	MP0001756_abnormal_urination	0.79162876
95	MP0009697_abnormal_copulation	0.78294599
96	MP0005395_other_phenotype	0.78123603
97	MP0005195_abnormal_posterior_eye	0.77083213
98	MP0000371_diluted_coat_color	0.76921178
99	MP0004885_abnormal_endolymph	0.76366233
100	MP0005636_abnormal_mineral_homeostasis	0.72496559

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.39324761
2	Abnormality of midbrain morphology (HP:0002418)	3.96863285
3	Molar tooth sign on MRI (HP:0002419)	3.96863285
4	Pancreatic fibrosis (HP:0100732)	3.75490672
5	True hermaphroditism (HP:0010459)	3.64034145
6	Attenuation of retinal blood vessels (HP:0007843)	3.37063876
7	Congenital stationary night blindness (HP:0007642)	3.34813082
8	Abnormality of the renal cortex (HP:0011035)	3.31535123
9	Nephronophthisis (HP:0000090)	3.29327585
10	Type II lissencephaly (HP:0007260)	3.10883904
11	Hyperventilation (HP:0002883)	3.09185587
12	Medial flaring of the eyebrow (HP:0010747)	3.02873628
13	Chronic hepatic failure (HP:0100626)	3.02007335
14	Cystic liver disease (HP:0006706)	2.88184886
15	Abnormality of the renal medulla (HP:0100957)	2.87029614
16	Abolished electroretinogram (ERG) (HP:0000550)	2.85350105
17	Abnormality of alanine metabolism (HP:0010916)	2.80408801
18	Hyperalaninemia (HP:0003348)	2.80408801
19	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.80408801
20	Gaze-evoked nystagmus (HP:0000640)	2.77327838
21	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.72032814
22	Abnormal rod and cone electroretinograms (HP:0008323)	2.68477995
23	Pendular nystagmus (HP:0012043)	2.67525028
24	Decreased central vision (HP:0007663)	2.67004639
25	Renal cortical cysts (HP:0000803)	2.65674337
26	Keratoconus (HP:0000563)	2.62225631
27	Increased corneal curvature (HP:0100692)	2.62225631
28	Progressive cerebellar ataxia (HP:0002073)	2.61344641
29	Methylmalonic acidemia (HP:0002912)	2.57779586
30	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.50452883
31	Tubular atrophy (HP:0000092)	2.48167131
32	Inability to walk (HP:0002540)	2.45573955
33	Stomach cancer (HP:0012126)	2.44546448
34	Methylmalonic aciduria (HP:0012120)	2.42847484
35	Congenital sensorineural hearing impairment (HP:0008527)	2.42575052
36	Genetic anticipation (HP:0003743)	2.42128653
37	Gait imbalance (HP:0002141)	2.41642829
38	Congenital primary aphakia (HP:0007707)	2.40269315
39	Cerebellar dysplasia (HP:0007033)	2.38725189
40	Abnormality of macular pigmentation (HP:0008002)	2.35728555
41	Polydipsia (HP:0001959)	2.30132080
42	Abnormal drinking behavior (HP:0030082)	2.30132080
43	Hypothermia (HP:0002045)	2.29757476
44	Abnormality of vitamin B metabolism (HP:0004340)	2.19574084
45	Sclerocornea (HP:0000647)	2.19141780
46	Nephrogenic diabetes insipidus (HP:0009806)	2.18786745
47	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.18117711
48	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.16212738
49	Hyperglycinemia (HP:0002154)	2.12449568
50	Bony spicule pigmentary retinopathy (HP:0007737)	2.12079452
51	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.11528661
52	Increased CSF lactate (HP:0002490)	2.09869379
53	3-Methylglutaconic aciduria (HP:0003535)	2.08697209
54	Progressive inability to walk (HP:0002505)	2.06886466
55	Lissencephaly (HP:0001339)	2.06537345
56	Bile duct proliferation (HP:0001408)	2.04155946
57	Abnormal biliary tract physiology (HP:0012439)	2.04155946
58	Febrile seizures (HP:0002373)	2.02677494
59	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.02574859
60	Genital tract atresia (HP:0001827)	2.01735710
61	Congenital hepatic fibrosis (HP:0002612)	2.01409741
62	Hyperglycinuria (HP:0003108)	1.97866320
63	Opisthotonus (HP:0002179)	1.95115935
64	Furrowed tongue (HP:0000221)	1.94508830
65	Vaginal atresia (HP:0000148)	1.92966011
66	Mitochondrial inheritance (HP:0001427)	1.91786728
67	Abnormality of the pons (HP:0007361)	1.91730869
68	Type I transferrin isoform profile (HP:0003642)	1.91612473
69	Retinitis pigmentosa (HP:0000510)	1.88881259
70	Polyuria (HP:0000103)	1.87704186
71	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.87492626
72	Abnormal protein N-linked glycosylation (HP:0012347)	1.87492626
73	Abnormal protein glycosylation (HP:0012346)	1.87492626
74	Abnormal glycosylation (HP:0012345)	1.87492626
75	Hypoplasia of the pons (HP:0012110)	1.86783409
76	Ketosis (HP:0001946)	1.85580678
77	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.85321494
78	Absent/shortened dynein arms (HP:0200106)	1.85321494
79	Severe visual impairment (HP:0001141)	1.84973877
80	Hepatocellular necrosis (HP:0001404)	1.83131331
81	Acute encephalopathy (HP:0006846)	1.80433084
82	Hepatic necrosis (HP:0002605)	1.80078935
83	Male pseudohermaphroditism (HP:0000037)	1.79339580
84	Poor coordination (HP:0002370)	1.78962083
85	Dialeptic seizures (HP:0011146)	1.77221646
86	Anencephaly (HP:0002323)	1.77031307
87	Astigmatism (HP:0000483)	1.77012344
88	Acute necrotizing encephalopathy (HP:0006965)	1.76230849
89	Abnormality of glycine metabolism (HP:0010895)	1.76008617
90	Abnormality of serine family amino acid metabolism (HP:0010894)	1.76008617
91	Postaxial foot polydactyly (HP:0001830)	1.75722500
92	Short tibia (HP:0005736)	1.75003199
93	Hypoplasia of the fovea (HP:0007750)	1.74999849
94	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.74999849
95	Large for gestational age (HP:0001520)	1.73787973
96	Abnormality of the ileum (HP:0001549)	1.73653190
97	Absent speech (HP:0001344)	1.73372688
98	Macular degeneration (HP:0000608)	1.73336953
99	Albinism (HP:0001022)	1.72400515
100	Increased serum lactate (HP:0002151)	1.71072119

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.95154691
2	MAP4K2	3.25685176
3	ACVR1B	3.04077011
4	ADRBK2	2.91356552
5	ZAK	2.68805653
6	NUAK1	2.63469321
7	BMPR1B	2.59625644
8	TAOK3	2.46235277
9	GRK1	2.16297644
10	WNK3	2.15599047
11	INSRR	2.07316235
12	TRIM28	2.06375339
13	TNIK	2.04133483
14	OXSR1	1.86633818
15	MAPK13	1.80485245
16	PINK1	1.55441422
17	WNK4	1.49830457
18	STK39	1.37211694
19	PDK2	1.27306839
20	STK38L	1.25896472
21	EIF2AK3	1.19798892
22	PIK3CG	1.18190150
23	DAPK2	1.15293561
24	TLK1	1.14601102
25	TNK2	1.11849126
26	TXK	1.10710584
27	MUSK	1.05779249
28	MKNK2	1.05307498
29	PTK2B	1.04462148
30	CASK	1.03946108
31	ADRBK1	1.03507809
32	BCKDK	1.03410196
33	EPHA4	1.02514088
34	NME1	1.00056667
35	NTRK3	0.98224605
36	VRK1	0.96064569
37	MST4	0.93995781
38	MAPKAPK3	0.93294691
39	PAK3	0.86841734
40	PIK3CA	0.84215321
41	TEC	0.83899870
42	MAP3K4	0.81244542
43	KIT	0.80802563
44	PRKCE	0.80378611
45	PLK4	0.71744442
46	MAPKAPK5	0.70259692
47	PRKCG	0.69804476
48	NEK2	0.69311718
49	IRAK1	0.68351723
50	PLK3	0.68304204
51	STK3	0.67563831
52	CAMKK2	0.63656055
53	BRSK2	0.62729452
54	FGFR2	0.61504151
55	FER	0.61503226
56	NEK1	0.61456819
57	CSNK1A1L	0.61206246
58	IKBKB	0.61018991
59	MAP2K6	0.60433144
60	FLT3	0.59299371
61	LATS1	0.58151813
62	MKNK1	0.57972600
63	GRK5	0.56705507
64	PLK2	0.56655748
65	CDK19	0.56592881
66	CSNK1G1	0.56126460
67	CSNK1G2	0.56091293
68	BMPR2	0.55583703
69	PRKCQ	0.54357711
70	TGFBR1	0.53647412
71	VRK2	0.52778222
72	CSNK1G3	0.49553790
73	DYRK2	0.47025623
74	PKN1	0.45819457
75	ATR	0.45206872
76	PRKAA2	0.44737125
77	CCNB1	0.43834611
78	PRKACA	0.42965128
79	CAMK2A	0.41937176
80	EIF2AK1	0.41793227
81	PNCK	0.41537142
82	EIF2AK2	0.40766897
83	TIE1	0.40524906
84	CAMK1	0.39798870
85	MARK3	0.39777188
86	SIK2	0.38305654
87	BCR	0.38087913
88	MAPK11	0.38028489
89	ERBB2	0.37916352
90	CSNK1A1	0.37485964
91	MARK1	0.37273186
92	TRPM7	0.37204992
93	PLK1	0.36660593
94	RPS6KA5	0.36378447
95	GRK6	0.36110472
96	PRKAA1	0.35466380
97	PRKACB	0.35091537
98	SYK	0.33922869
99	NLK	0.33638351
100	ATM	0.31667708

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Butanoate metabolism_Homo sapiens_hsa00650	2.74307569
2	Phototransduction_Homo sapiens_hsa04744	2.61591429
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.58165403
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.55718346
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.44928667
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.42761854
7	Homologous recombination_Homo sapiens_hsa03440	2.35067709
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.27559059
9	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.22000933
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.21884699
11	Tryptophan metabolism_Homo sapiens_hsa00380	2.14445303
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.08050606
13	Fanconi anemia pathway_Homo sapiens_hsa03460	2.03594262
14	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.96706456
15	Propanoate metabolism_Homo sapiens_hsa00640	1.95107420
16	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.92705518
17	Ether lipid metabolism_Homo sapiens_hsa00565	1.82405355
18	Selenocompound metabolism_Homo sapiens_hsa00450	1.76144700
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.69996510
20	ABC transporters_Homo sapiens_hsa02010	1.66473547
21	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.66026812
22	Caffeine metabolism_Homo sapiens_hsa00232	1.62198824
23	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.54049508
24	Peroxisome_Homo sapiens_hsa04146	1.53195291
25	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.50887086
26	Olfactory transduction_Homo sapiens_hsa04740	1.50881956
27	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.47578797
28	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.45928075
29	One carbon pool by folate_Homo sapiens_hsa00670	1.41167901
30	RNA polymerase_Homo sapiens_hsa03020	1.41092494
31	Nicotine addiction_Homo sapiens_hsa05033	1.37896844
32	Basal transcription factors_Homo sapiens_hsa03022	1.31548685
33	Chemical carcinogenesis_Homo sapiens_hsa05204	1.30533211
34	Fat digestion and absorption_Homo sapiens_hsa04975	1.28856256
35	Histidine metabolism_Homo sapiens_hsa00340	1.26055838
36	Oxidative phosphorylation_Homo sapiens_hsa00190	1.22781642
37	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.21558952
38	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.20946199
39	Taste transduction_Homo sapiens_hsa04742	1.15673807
40	Retinol metabolism_Homo sapiens_hsa00830	1.13478772
41	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.10884417
42	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.04824998
43	RNA degradation_Homo sapiens_hsa03018	1.02919651
44	Protein export_Homo sapiens_hsa03060	1.02320555
45	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.00701464
46	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.99340099
47	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.99149596
48	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.97724712
49	Purine metabolism_Homo sapiens_hsa00230	0.95548811
50	Glycerolipid metabolism_Homo sapiens_hsa00561	0.94762198
51	Fatty acid degradation_Homo sapiens_hsa00071	0.94364604
52	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.93512633
53	Parkinsons disease_Homo sapiens_hsa05012	0.93495866
54	Asthma_Homo sapiens_hsa05310	0.93303638
55	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.86541702
56	beta-Alanine metabolism_Homo sapiens_hsa00410	0.86131515
57	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.85913717
58	Fatty acid metabolism_Homo sapiens_hsa01212	0.81576079
59	Mineral absorption_Homo sapiens_hsa04978	0.81188815
60	Fatty acid elongation_Homo sapiens_hsa00062	0.80670598
61	Non-homologous end-joining_Homo sapiens_hsa03450	0.79210094
62	Morphine addiction_Homo sapiens_hsa05032	0.78650804
63	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.78563761
64	Metabolic pathways_Homo sapiens_hsa01100	0.77654375
65	Regulation of autophagy_Homo sapiens_hsa04140	0.76974999
66	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.76430853
67	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.75215197
68	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.73399485
69	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.69859903
70	Salivary secretion_Homo sapiens_hsa04970	0.69456966
71	Calcium signaling pathway_Homo sapiens_hsa04020	0.68228932
72	Arginine and proline metabolism_Homo sapiens_hsa00330	0.66153244
73	Pyrimidine metabolism_Homo sapiens_hsa00240	0.66086981
74	Huntingtons disease_Homo sapiens_hsa05016	0.64491744
75	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.59247744
76	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.58969957
77	Serotonergic synapse_Homo sapiens_hsa04726	0.56431556
78	Circadian entrainment_Homo sapiens_hsa04713	0.55061742
79	Primary immunodeficiency_Homo sapiens_hsa05340	0.54540899
80	Sulfur metabolism_Homo sapiens_hsa00920	0.53303562
81	Glutamatergic synapse_Homo sapiens_hsa04724	0.52062776
82	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.49665340
83	Sulfur relay system_Homo sapiens_hsa04122	0.49130119
84	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.48379489
85	Insulin secretion_Homo sapiens_hsa04911	0.47652478
86	Sphingolipid metabolism_Homo sapiens_hsa00600	0.46243501
87	Glutathione metabolism_Homo sapiens_hsa00480	0.45707332
88	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.44979130
89	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.44849902
90	Alzheimers disease_Homo sapiens_hsa05010	0.43151616
91	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.42435364
92	GABAergic synapse_Homo sapiens_hsa04727	0.40918546
93	Nucleotide excision repair_Homo sapiens_hsa03420	0.40548010
94	Proteasome_Homo sapiens_hsa03050	0.40464807
95	Steroid biosynthesis_Homo sapiens_hsa00100	0.39608387
96	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.38828060
97	Base excision repair_Homo sapiens_hsa03410	0.36398989
98	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.35713787
99	Lysine degradation_Homo sapiens_hsa00310	0.33957546
100	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.33062134

LCN15

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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