LCN6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of thymocyte apoptotic process (GO:0070244)9.63645924
2regulation of chronic inflammatory response (GO:0002676)8.83651846
3tryptophan catabolic process (GO:0006569)8.77471103
4indole-containing compound catabolic process (GO:0042436)8.77471103
5indolalkylamine catabolic process (GO:0046218)8.77471103
6heterotypic cell-cell adhesion (GO:0034113)8.51456687
7V(D)J recombination (GO:0033151)8.34846126
8negative regulation of interleukin-10 production (GO:0032693)7.55949196
9tryptophan metabolic process (GO:0006568)7.34040972
10positive regulation of type 2 immune response (GO:0002830)6.89122276
11cellular response to ethanol (GO:0071361)6.81316866
12response to hydroperoxide (GO:0033194)6.11430071
13* single fertilization (GO:0007338)6.02188991
14cellular biogenic amine catabolic process (GO:0042402)5.94775747
15amine catabolic process (GO:0009310)5.94775747
16aromatic amino acid family catabolic process (GO:0009074)5.88818539
17indolalkylamine metabolic process (GO:0006586)5.38242301
18regulation of thymocyte apoptotic process (GO:0070243)5.16614217
19regulation of actin filament-based movement (GO:1903115)5.13708761
20negative regulation of interleukin-8 production (GO:0032717)5.04755748
21T cell lineage commitment (GO:0002360)4.99367658
22negative regulation of T cell apoptotic process (GO:0070233)4.81324969
23cardiac muscle hypertrophy (GO:0003300)4.71539483
24T cell homeostasis (GO:0043029)4.66077649
25benzene-containing compound metabolic process (GO:0042537)4.64171166
26striated muscle hypertrophy (GO:0014897)4.45273399
27regulation of relaxation of muscle (GO:1901077)4.40013787
28T cell differentiation in thymus (GO:0033077)4.37741434
29regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.35932331
30regulation of cardiac muscle cell contraction (GO:0086004)4.33140753
31interleukin-6-mediated signaling pathway (GO:0070102)4.29076977
32positive regulation of cell-cell adhesion (GO:0022409)4.28588236
33regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.24361983
34digestion (GO:0007586)4.23554182
35aromatic amino acid family metabolic process (GO:0009072)4.23043275
36transepithelial transport (GO:0070633)4.16520689
37N-acetylneuraminate metabolic process (GO:0006054)4.16036914
38cardiac muscle hypertrophy in response to stress (GO:0014898)4.13153722
39muscle hypertrophy in response to stress (GO:0003299)4.13153722
40cardiac muscle adaptation (GO:0014887)4.13153722
41* fertilization (GO:0009566)4.12925664
42muscle hypertrophy (GO:0014896)4.12670141
43response to inactivity (GO:0014854)4.12308157
44indole-containing compound metabolic process (GO:0042430)4.10542872
45response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.08278612
46negative regulation of endopeptidase activity (GO:0010951)4.02927545
47epithelial cell morphogenesis (GO:0003382)4.01111351
48cardiac myofibril assembly (GO:0055003)3.99582685
49negative regulation of peptidase activity (GO:0010466)3.87372355
50cardiac muscle contraction (GO:0060048)3.85070176
51DNA topological change (GO:0006265)3.84594098
52sarcomere organization (GO:0045214)3.82968280
53labyrinthine layer development (GO:0060711)3.77714265
54actin-myosin filament sliding (GO:0033275)3.76103460
55muscle filament sliding (GO:0030049)3.76103460
56regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.76009462
57regulation of type 2 immune response (GO:0002828)3.73880304
58radial glial cell differentiation (GO:0060019)3.68625292
59myofibril assembly (GO:0030239)3.68173306
60B cell differentiation (GO:0030183)3.50823781
61positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.49723776
62negative regulation of protein autophosphorylation (GO:0031953)3.48086155
63carnitine shuttle (GO:0006853)3.46212536
64positive regulation of B cell differentiation (GO:0045579)3.43182040
65detection of calcium ion (GO:0005513)3.39571273
66valine metabolic process (GO:0006573)3.38210770
67defense response to bacterium (GO:0042742)3.37656794
68cellular response to exogenous dsRNA (GO:0071360)3.29865549
69sialylation (GO:0097503)3.29458251
70regulation of striated muscle contraction (GO:0006942)3.29083462
71regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.28042122
72regulation of cell communication by electrical coupling (GO:0010649)3.27362266
73regulation of vitamin metabolic process (GO:0030656)3.27342614
74regulation of dendritic cell antigen processing and presentation (GO:0002604)3.23047203
75positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.17314651
76somatic cell DNA recombination (GO:0016444)3.16103017
77somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.16103017
78actin-mediated cell contraction (GO:0070252)3.14742984
79B cell receptor signaling pathway (GO:0050853)3.14155265
80bundle of His cell to Purkinje myocyte communication (GO:0086069)3.09894444
81regulation of cardiac muscle contraction (GO:0055117)3.08438156
82fatty acid transmembrane transport (GO:1902001)3.07572323
83reverse cholesterol transport (GO:0043691)3.07007937
84lymphocyte homeostasis (GO:0002260)3.06255930
85cellular response to epinephrine stimulus (GO:0071872)3.04959636
86B cell proliferation (GO:0042100)3.03675918
87cellular response to reactive nitrogen species (GO:1902170)3.02739488
88positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.02645291
89seminiferous tubule development (GO:0072520)23.2162597
90response to bacterium (GO:0009617)2.96889075
91metanephric epithelium development (GO:0072207)2.95874193
92negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.93266958
93negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.92990300
94sulfur amino acid catabolic process (GO:0000098)2.92981700
95histone monoubiquitination (GO:0010390)2.92955900
96somatic diversification of immune receptors (GO:0002200)2.91182259
97striated muscle contraction (GO:0006941)2.91108586
98actomyosin structure organization (GO:0031032)2.87389772
99homocysteine metabolic process (GO:0050667)2.87373352
100negative regulation of lymphocyte apoptotic process (GO:0070229)2.86945243
101regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.84821012
102cellular response to fluid shear stress (GO:0071498)2.83735177
103germinal center formation (GO:0002467)2.83154759
104ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.82642495
105positive regulation of cation channel activity (GO:2001259)2.81638721
106cellular anion homeostasis (GO:0030002)2.80936397
107negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.80752450
108regulation of clathrin-mediated endocytosis (GO:2000369)2.80405544
109regulation of activated T cell proliferation (GO:0046006)2.79817118
110cardiac muscle tissue morphogenesis (GO:0055008)2.78959784
111striated muscle adaptation (GO:0014888)2.78302813
112leukocyte homeostasis (GO:0001776)2.77039656
113epithelial cell differentiation involved in kidney development (GO:0035850)2.76433158
114negative regulation of granulocyte differentiation (GO:0030853)2.74792238
115resolution of meiotic recombination intermediates (GO:0000712)2.74765811
116interkinetic nuclear migration (GO:0022027)2.72467345
117positive thymic T cell selection (GO:0045059)2.71838398
118negative regulation of potassium ion transmembrane transport (GO:1901380)2.71691777
119positive regulation of organ growth (GO:0046622)2.71024104
120regulation of female gonad development (GO:2000194)2.70832388
121positive regulation of interleukin-12 production (GO:0032735)2.69902945
122heparin biosynthetic process (GO:0030210)2.69307674
123heparin metabolic process (GO:0030202)2.69307674
124response to epinephrine (GO:0071871)2.68532255
125positive regulation of uterine smooth muscle contraction (GO:0070474)2.67501090
126negative regulation of proteolysis (GO:0045861)2.67093267
127negative regulation of glial cell proliferation (GO:0060253)2.66883696
128ventricular cardiac muscle cell action potential (GO:0086005)2.66830827
129regulation of beta-amyloid formation (GO:1902003)2.66488007
130positive regulation of action potential (GO:0045760)2.65290989
131urinary tract smooth muscle contraction (GO:0014848)2.64757497
132regulation of calcium ion transmembrane transporter activity (GO:1901019)2.64002357
133regulation of calcium ion transmembrane transport (GO:1903169)2.64002357
134cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.63649821
135regulation of the force of heart contraction (GO:0002026)2.62872653
136potassium ion export (GO:0071435)2.62393463
137phospholipid homeostasis (GO:0055091)2.61395561
138negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.58369521
139negative regulation of T-helper cell differentiation (GO:0045623)2.58369521
140regulation of T-helper 2 cell differentiation (GO:0045628)2.57465677
141negative regulation of protein processing (GO:0010955)2.56801592
142negative regulation of protein maturation (GO:1903318)2.56801592
143positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.55961949
144regulation of sequestering of triglyceride (GO:0010889)2.54661308
145regulation of antigen processing and presentation (GO:0002577)2.54536501
146carnitine transmembrane transport (GO:1902603)2.53908009
147regulation of macrophage activation (GO:0043030)2.53615234
148glial cell proliferation (GO:0014009)2.52538990
149muscle adaptation (GO:0043500)2.52146094
150Rap protein signal transduction (GO:0032486)2.51602033
151DNA unwinding involved in DNA replication (GO:0006268)2.51194136
152regulation of uterine smooth muscle contraction (GO:0070472)2.50411476
153O-glycan processing (GO:0016266)2.50326020
154blood vessel maturation (GO:0001955)2.49918754
155negative regulation of glycoprotein biosynthetic process (GO:0010561)2.49550150
156regulation of lipoprotein metabolic process (GO:0050746)2.48368627
157regulation of T cell apoptotic process (GO:0070232)2.44850020
158positive regulation of cellular amide metabolic process (GO:0034250)2.43624806
159cellular modified amino acid catabolic process (GO:0042219)2.42146018
160complement activation, alternative pathway (GO:0006957)2.42048580
161trivalent inorganic anion homeostasis (GO:0072506)2.39117519
162phosphate ion homeostasis (GO:0055062)2.39117519
163poly(A)+ mRNA export from nucleus (GO:0016973)2.38779215
164positive regulation of sterol transport (GO:0032373)2.38295940
165positive regulation of cholesterol transport (GO:0032376)2.38295940
166negative regulation of leukocyte apoptotic process (GO:2000107)2.38026044
167alpha-amino acid catabolic process (GO:1901606)2.34915717
168positive regulation of gamma-delta T cell activation (GO:0046645)2.32873930
169negative regulation of hydrolase activity (GO:0051346)2.32496988
170negative regulation of glycogen biosynthetic process (GO:0045719)2.32245414
171cellular amino acid catabolic process (GO:0009063)2.29888267
172fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.28612880
173alpha-linolenic acid metabolic process (GO:0036109)2.26535414
174branched-chain amino acid catabolic process (GO:0009083)2.26408374
175regulation of endopeptidase activity (GO:0052548)2.23882536
176glycine transport (GO:0015816)2.23805713
177regulation of respiratory burst (GO:0060263)2.20120867
178nerve growth factor signaling pathway (GO:0038180)2.19589547
179regulation of interleukin-10 production (GO:0032653)2.18795617
180high-density lipoprotein particle remodeling (GO:0034375)2.18401782
181columnar/cuboidal epithelial cell development (GO:0002066)2.18255758
182regulation of amyloid precursor protein catabolic process (GO:1902991)2.18017936
183CDP-diacylglycerol biosynthetic process (GO:0016024)2.14539630
184positive T cell selection (GO:0043368)2.13196033
185regulation of peptidase activity (GO:0052547)2.12627174
186negative thymic T cell selection (GO:0045060)2.10728364
187positive regulation of filopodium assembly (GO:0051491)2.10157699
188pyrimidine ribonucleoside catabolic process (GO:0046133)2.09919136
189negative T cell selection (GO:0043383)2.09554655
190regulation of defense response to virus by virus (GO:0050690)2.09362394
191L-serine transport (GO:0015825)2.08583203
192regulation of T cell tolerance induction (GO:0002664)13.8529465
193production of molecular mediator involved in inflammatory response (GO:0002532)13.0762257
194positive regulation of tolerance induction (GO:0002645)11.5882968
195sperm capacitation (GO:0048240)10.9100123
196kynurenine metabolic process (GO:0070189)10.2727862
197regulation of tolerance induction (GO:0002643)10.1542963

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.64437117
2GATA1_22025678_ChIP-Seq_K562_Human5.06820516
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.89511656
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.66097344
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.73288036
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.67446379
7IKZF1_21737484_ChIP-ChIP_HCT116_Human3.42965775
8FLI1_27457419_Chip-Seq_LIVER_Mouse3.30937892
9AR_21572438_ChIP-Seq_LNCaP_Human3.15043731
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.10433070
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.70592907
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.65299311
13RUNX_20019798_ChIP-Seq_JUKART_Human2.63743469
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.52633286
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.46396067
16DNAJC2_21179169_ChIP-ChIP_NT2_Human2.40745395
17ESR1_21235772_ChIP-Seq_MCF-7_Human2.35448588
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.30118210
19SCL_19346495_ChIP-Seq_HPC-7_Human2.27033988
20SUZ12_27294783_Chip-Seq_NPCs_Mouse2.24532770
21EP300_21415370_ChIP-Seq_HL-1_Mouse2.23450125
22EGR1_23403033_ChIP-Seq_LIVER_Mouse2.11094126
23SMAD1_18555785_Chip-Seq_ESCs_Mouse2.08594971
24CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.07207239
25LXR_22158963_ChIP-Seq_LIVER_Mouse2.02832606
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.02212668
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93976889
28NFE2_27457419_Chip-Seq_LIVER_Mouse1.91584499
29STAT1_17558387_ChIP-Seq_HELA_Human1.90461237
30ESRRB_18555785_Chip-Seq_ESCs_Mouse1.89196919
31MYC_22102868_ChIP-Seq_BL_Human1.84931373
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.84818135
33RXR_22158963_ChIP-Seq_LIVER_Mouse1.84484410
34VDR_24763502_ChIP-Seq_THP-1_Human1.83681999
35ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.82165226
36SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.80738270
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.80244364
38LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.76759531
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.75481829
40BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.75421470
41VDR_21846776_ChIP-Seq_THP-1_Human1.73979500
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.71042421
43GATA3_21867929_ChIP-Seq_TH1_Mouse1.70422783
44CTCF_18555785_Chip-Seq_ESCs_Mouse1.67231515
45TBX20_22328084_ChIP-Seq_HEART_Mouse1.64102438
46TBX20_22080862_ChIP-Seq_HEART_Mouse1.64102438
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.63274641
48SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.63137583
49RAD21_21589869_ChIP-Seq_MESCs_Mouse1.63103750
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.60546954
51FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.60213297
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.59900798
53SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.58680859
54GATA1_19941827_ChIP-Seq_MEL_Mouse1.56933467
55NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.54882704
56ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.54091446
57FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.53817183
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.53196217
59SPI1_23127762_ChIP-Seq_K562_Human1.52938794
60* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.52841000
61* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50737422
62MYB_26560356_Chip-Seq_TH2_Human1.49917600
63WT1_19549856_ChIP-ChIP_CCG9911_Human1.48439736
64KDM2B_26808549_Chip-Seq_REH_Human1.48290273
65FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.48167371
66PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.46719117
67PPARA_22158963_ChIP-Seq_LIVER_Mouse1.46717560
68EZH2_22144423_ChIP-Seq_EOC_Human1.44152728
69RNF2_18974828_ChIP-Seq_MESCs_Mouse1.44098547
70EZH2_18974828_ChIP-Seq_MESCs_Mouse1.44098547
71MYB_21317192_ChIP-Seq_ERMYB_Mouse1.43772146
72NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.43501469
73SALL4_22934838_ChIP-ChIP_CD34+_Human1.41933024
74REST_19997604_ChIP-ChIP_NEURONS_Mouse1.41639118
75TCF7_22412390_ChIP-Seq_EML_Mouse1.41552673
76SMAD4_21741376_ChIP-Seq_HESCs_Human1.39403937
77SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.36483803
78CBX2_27304074_Chip-Seq_ESCs_Mouse1.36148884
79RUNX1_27457419_Chip-Seq_LIVER_Mouse1.36078579
80Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.35861770
81IRF8_27001747_Chip-Seq_BMDM_Mouse1.35758096
82DROSHA_22980978_ChIP-Seq_HELA_Human1.34835315
83EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.33538481
84MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.32575504
85GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31456995
86STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.28706426
87SOX2_18555785_Chip-Seq_ESCs_Mouse1.27419971
88TET1_21451524_ChIP-Seq_MESCs_Mouse1.27160354
89PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26544064
90RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24728933
91CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23266948
92GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22971560
93ZFX_18555785_Chip-Seq_ESCs_Mouse1.22605339
94ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21792152
95GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21476983
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21432843
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21432843
98SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.21342471
99HTT_18923047_ChIP-ChIP_STHdh_Human1.20883913
100GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.20551243
101FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.20345299
102CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20060715
103GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.19275825
104KDM2B_26808549_Chip-Seq_DND41_Human1.18941743
105SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.18755526
106TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18678822
107MYC_19915707_ChIP-ChIP_AK7_Human1.18638289
108SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.16667955
109SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15366786
110GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15134848
111P68_20966046_ChIP-Seq_HELA_Human1.14950023
112GATA3_27048872_Chip-Seq_THYMUS_Human1.14803149
113TRIM28_21343339_ChIP-Seq_HEK293_Human1.14745464
114STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13597916
115KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13480145
116OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13016658
117SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.11006044
118GATA1_19941826_ChIP-Seq_K562_Human1.10264347
119CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09852615
120RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09373305
121SMAD3_21741376_ChIP-Seq_HESCs_Human1.08685935
122KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06971894
123GATA1_19941827_ChIP-Seq_MEL86_Mouse1.06467621
124RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06452592
125CRX_20693478_ChIP-Seq_RETINA_Mouse1.06423557
126GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05979445
127EGR1_19374776_ChIP-ChIP_THP-1_Human1.05755347
128JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.05599251
129FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04899498
130MYC_27129775_Chip-Seq_CORNEA_Mouse1.04798727
131EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04774399
132LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04132279
133EZH2_27304074_Chip-Seq_ESCs_Mouse1.03519063
134GF1_26923725_Chip-Seq_HPCs_Mouse1.03129346
135SOX2_20726797_ChIP-Seq_SW620_Human1.02996044
136SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02268187
137UTX_26944678_Chip-Seq_JUKART_Human1.01816338
138VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01797947
139NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01661246
140SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.99846216
141TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.99425293
142VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99317611
143KLF4_18555785_Chip-Seq_ESCs_Mouse0.99058728
144TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98578230
145BCL6_27268052_Chip-Seq_Bcells_Human0.98134858
146GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98086041
147NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97958459
148PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97700815
149NR3C1_23031785_ChIP-Seq_PC12_Mouse0.97360410
150MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.97001377
151NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.95995738
152ELF1_20517297_ChIP-Seq_JURKAT_Human0.94919054
153MTF2_20144788_ChIP-Seq_MESCs_Mouse0.94729785
154PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93852862
155SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.92936130
156BRD4_27068464_Chip-Seq_AML-cells_Mouse0.91765407
157VDR_24787735_ChIP-Seq_THP-1_Human0.91504277
158IRF8_21731497_ChIP-ChIP_J774_Mouse0.91366235
159SOX9_24532713_ChIP-Seq_HFSC_Mouse0.91354296
160JARID2_20064375_ChIP-Seq_MESCs_Mouse0.90856884
161MYB_26560356_Chip-Seq_TH1_Human0.90163005
162SMC4_20622854_ChIP-Seq_HELA_Human0.90096996
163* FLI1_21867929_ChIP-Seq_CD8_Mouse0.89852869
164REST_18959480_ChIP-ChIP_MESCs_Mouse0.89008075
165MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.88853874
166ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88851851
167NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88626682
168CTNNB1_20460455_ChIP-Seq_HCT116_Human0.88546722
169ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88507287
170SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88293084
171RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.88008079
172EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.87305976
173WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86833091
174P53_22387025_ChIP-Seq_ESCs_Mouse0.86341033
175BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85972110
176* ELK3_25401928_ChIP-Seq_HUVEC_Human0.83378341
177CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.82995721
178MAF_26560356_Chip-Seq_TH1_Human0.82170813
179SMRT_27268052_Chip-Seq_Bcells_Human0.80370980
180PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79977911
181PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.79653273
182GATA4_21415370_ChIP-Seq_HL-1_Mouse0.77985766
183TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77591964
184AHR_22903824_ChIP-Seq_MCF-7_Human0.76099916
185RUNX1_22412390_ChIP-Seq_EML_Mouse0.74957226
186TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.73093280
187DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.71997281

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle5.28849630
2MP0002254_reproductive_system_inflammat4.76391879
3MP0002132_abnormal_respiratory_system4.67634950
4MP0002166_altered_tumor_susceptibility4.38730663
5MP0003303_peritoneal_inflammation4.33931877
6MP0009278_abnormal_bone_marrow4.25328033
7MP0003195_calcinosis4.19680803
8MP0004036_abnormal_muscle_relaxation3.37704721
9MP0010234_abnormal_vibrissa_follicle3.18254741
10MP0005410_abnormal_fertilization3.16564710
11MP0002139_abnormal_hepatobiliary_system3.12968591
12MP0004043_abnormal_pH_regulation3.11830804
13MP0002006_tumorigenesis3.10789439
14MP0005670_abnormal_white_adipose2.96937960
15MP0003300_gastrointestinal_ulcer2.86445046
16MP0005058_abnormal_lysosome_morphology2.82695034
17MP0002138_abnormal_hepatobiliary_system2.63969709
18MP0008004_abnormal_stomach_pH2.62311721
19MP0006138_congestive_heart_failure2.61057374
20MP0002933_joint_inflammation2.59315967
21MP0001849_ear_inflammation2.58601862
22MP0009379_abnormal_foot_pigmentation2.54912212
23MP0005360_urolithiasis2.45795990
24MP0003011_delayed_dark_adaptation2.44059096
25MP0001835_abnormal_antigen_presentation2.39200332
26MP0001545_abnormal_hematopoietic_system2.23334815
27MP0005397_hematopoietic_system_phenotyp2.23334815
28MP0010368_abnormal_lymphatic_system2.16335823
29MP0008775_abnormal_heart_ventricle2.15098245
30MP0009785_altered_susceptibility_to2.08925641
31MP0002009_preneoplasia2.07176141
32MP0003252_abnormal_bile_duct2.02805615
33MP0001765_abnormal_ion_homeostasis1.98510164
34MP0002127_abnormal_cardiovascular_syste1.97968970
35MP0003828_pulmonary_edema1.95937446
36MP0005365_abnormal_bile_salt1.94558006
37MP0004947_skin_inflammation1.93467875
38MP0003329_amyloid_beta_deposits1.89469922
39MP0005085_abnormal_gallbladder_physiolo1.85218347
40MP0002928_abnormal_bile_duct1.81916360
41MP0004145_abnormal_muscle_electrophysio1.81822540
42MP0004215_abnormal_myocardial_fiber1.80744390
43MP0002735_abnormal_chemical_nociception1.78369601
44MP0003646_muscle_fatigue1.73638337
45MP0005387_immune_system_phenotype1.72595828
46MP0001790_abnormal_immune_system1.72595828
47MP0003123_paternal_imprinting1.70868945
48MP0005330_cardiomyopathy1.70493531
49MP0004510_myositis1.68249113
50MP0001544_abnormal_cardiovascular_syste1.61656073
51MP0005385_cardiovascular_system_phenoty1.61656073
52MP0003806_abnormal_nucleotide_metabolis1.57950984
53MP0002168_other_aberrant_phenotype1.55914798
54MP0001756_abnormal_urination1.52356311
55MP0000003_abnormal_adipose_tissue1.51528131
56MP0009643_abnormal_urine_homeostasis1.49074977
57MP0000604_amyloidosis1.48400867
58MP0001853_heart_inflammation1.47953565
59MP0001800_abnormal_humoral_immune1.45885510
60MP0000751_myopathy1.45458793
61MP0001501_abnormal_sleep_pattern1.45378260
62MP0008875_abnormal_xenobiotic_pharmacok1.43015202
63MP0003950_abnormal_plasma_membrane1.41237268
64MP0010155_abnormal_intestine_physiology1.40819000
65MP0000566_synostosis1.40644731
66MP0005620_abnormal_muscle_contractility1.39944395
67MP0003724_increased_susceptibility_to1.38792492
68MP0005666_abnormal_adipose_tissue1.35204398
69MP0010329_abnormal_lipoprotein_level1.34333993
70MP0004087_abnormal_muscle_fiber1.31948267
71MP0010630_abnormal_cardiac_muscle1.30396861
72MP0002736_abnormal_nociception_after1.28443144
73MP0005636_abnormal_mineral_homeostasis1.27281106
74MP0002136_abnormal_kidney_physiology1.25047957
75MP0002998_abnormal_bone_remodeling1.24992737
76MP0005165_increased_susceptibility_to1.24870807
77MP0004808_abnormal_hematopoietic_stem1.24347844
78MP0005083_abnormal_biliary_tract1.24076047
79MP0002396_abnormal_hematopoietic_system1.23160076
80MP0001663_abnormal_digestive_system1.22692905
81MP0005000_abnormal_immune_tolerance1.22467382
82MP0003787_abnormal_imprinting1.22166779
83MP0005451_abnormal_body_composition1.19051732
84MP0005381_digestive/alimentary_phenotyp1.18726265
85MP0003959_abnormal_lean_body1.18371982
86MP0000462_abnormal_digestive_system1.15499584
87MP0004742_abnormal_vestibular_system1.13722939
88MP0002837_dystrophic_cardiac_calcinosis1.13294205
89MP0002106_abnormal_muscle_physiology1.12801665
90MP0004885_abnormal_endolymph1.11042358
91MP0005671_abnormal_response_to1.10290800
92MP0000613_abnormal_salivary_gland1.08856192
93MP0005332_abnormal_amino_acid1.08097373
94MP0003763_abnormal_thymus_physiology1.07934613
95MP0002332_abnormal_exercise_endurance1.01006325
96MP0000249_abnormal_blood_vessel1.00586515
97MP0003279_aneurysm1.00246839
98MP0002419_abnormal_innate_immunity1.00196947
99MP0004019_abnormal_vitamin_homeostasis0.99988599
100MP0000685_abnormal_immune_system0.99561342
101MP0002148_abnormal_hypersensitivity_rea0.99146585
102MP0000749_muscle_degeneration0.98431515
103MP0004859_abnormal_synaptic_plasticity0.97725167
104MP0001348_abnormal_lacrimal_gland0.96415429
105MP0001968_abnormal_touch/_nociception0.95723517
106MP0000013_abnormal_adipose_tissue0.95335752
107MP0001440_abnormal_grooming_behavior0.93940799
108MP0006276_abnormal_autonomic_nervous0.92069533
109MP0005535_abnormal_body_temperature0.91515683
110MP0000343_altered_response_to0.91380979
111MP0005084_abnormal_gallbladder_morpholo0.90206301
112MP0002452_abnormal_antigen_presenting0.89698303
113MP0001485_abnormal_pinna_reflex0.89123226
114MP0002398_abnormal_bone_marrow0.88821799
115MP0002733_abnormal_thermal_nociception0.88198770
116MP0001879_abnormal_lymphatic_vessel0.88175169
117MP0002877_abnormal_melanocyte_morpholog0.86932335
118MP0004085_abnormal_heartbeat0.86543302
119MP0002723_abnormal_immune_serum0.85070847
120MP0000538_abnormal_urinary_bladder0.84802508
121MP0000767_abnormal_smooth_muscle0.84741124
122MP0001486_abnormal_startle_reflex0.82004987
123MP0004130_abnormal_muscle_cell0.81798794
124MP0000733_abnormal_muscle_development0.81655887
125MP0000759_abnormal_skeletal_muscle0.81270593
126MP0003436_decreased_susceptibility_to0.80962220
127MP0005369_muscle_phenotype0.80928410
128MP0005375_adipose_tissue_phenotype0.80900455
129MP0002420_abnormal_adaptive_immunity0.78059021
130MP0005025_abnormal_response_to0.77818411
131MP0004484_altered_response_of0.77666707
132MP0000716_abnormal_immune_system0.77609208
133MP0002118_abnormal_lipid_homeostasis0.77423756
134MP0010094_abnormal_chromosome_stability0.77088573
135MP0003221_abnormal_cardiomyocyte_apopto0.76921156
136MP0003091_abnormal_cell_migration0.76757219
137MP0001819_abnormal_immune_cell0.75636457
138MP0003566_abnormal_cell_adhesion0.75048371
139MP0003698_abnormal_male_reproductive0.74921974
140MP0009115_abnormal_fat_cell0.74882948
141MP0003045_fibrosis0.74805270
142MP0002089_abnormal_postnatal_growth/wei0.73864893
143MP0009384_cardiac_valve_regurgitation0.72733798
144MP0000750_abnormal_muscle_regeneration0.72431305
145MP0009764_decreased_sensitivity_to0.72379680
146MP0009765_abnormal_xenobiotic_induced0.72236447
147MP0003137_abnormal_impulse_conducting0.69366906
148MP0001986_abnormal_taste_sensitivity0.69210777
149MP0005166_decreased_susceptibility_to0.68990578
150MP0005167_abnormal_blood-brain_barrier0.68989145
151MP0000747_muscle_weakness0.68985753
152MP0001346_abnormal_lacrimal_gland0.68945867
153MP0004381_abnormal_hair_follicle0.68174092
154MP0005464_abnormal_platelet_physiology0.67395027
155MP0005584_abnormal_enzyme/coenzyme_acti0.66313961
156MP0001970_abnormal_pain_threshold0.66272815
157MP0003690_abnormal_glial_cell0.65229521
158MP0000689_abnormal_spleen_morphology0.64767894
159MP0009745_abnormal_behavioral_response0.64152699
160MP0000703_abnormal_thymus_morphology0.63913338
161MP0000372_irregular_coat_pigmentation0.63848557
162MP0002405_respiratory_system_inflammati0.62459554
163MP0002972_abnormal_cardiac_muscle0.61574501
164MP0008872_abnormal_physiological_respon0.61486401
165MP0000920_abnormal_myelination0.60236975
166MP0002269_muscular_atrophy0.58995782
167MP0002722_abnormal_immune_system0.58775945
168MP0002876_abnormal_thyroid_physiology0.58457166
169MP0002429_abnormal_blood_cell0.58403020
170MP0002128_abnormal_blood_circulation0.58254605
171MP0002796_impaired_skin_barrier0.56437348
172MP0009763_increased_sensitivity_to0.56177377
173MP0002098_abnormal_vibrissa_morphology0.55836406
174MP0003656_abnormal_erythrocyte_physiolo0.55834141
175MP0005319_abnormal_enzyme/_coenzyme0.55378618
176MP0005595_abnormal_vascular_smooth0.54660361
177MP0005253_abnormal_eye_physiology0.53922140
178MP0000266_abnormal_heart_morphology0.52305184
179MP0001661_extended_life_span0.51602386
180MP0001784_abnormal_fluid_regulation0.50562668

Predicted human phenotypes

RankGene SetZ-score
1Severe combined immunodeficiency (HP:0004430)8.78233631
2Thyroiditis (HP:0100646)8.26758245
3Hypoproteinemia (HP:0003075)7.65842122
4Combined immunodeficiency (HP:0005387)7.07712826
5T lymphocytopenia (HP:0005403)6.31437358
6Eosinophilia (HP:0001880)5.92392973
7Progressive macrocephaly (HP:0004481)5.40099007
8Abnormality of T cell number (HP:0011839)5.19735152
9Granulocytopenia (HP:0001913)5.09183182
10Agammaglobulinemia (HP:0004432)4.99173864
11Erythroderma (HP:0001019)4.57233668
12Acute necrotizing encephalopathy (HP:0006965)4.49087521
13Recurrent viral infections (HP:0004429)4.45519649
14Conjunctival hamartoma (HP:0100780)4.38397055
15Abnormality of eosinophils (HP:0001879)4.21553485
16Abnormal hemoglobin (HP:0011902)4.12393788
17Sudden death (HP:0001699)4.05038679
18Acute encephalopathy (HP:0006846)4.00979319
19Abnormal mitochondria in muscle tissue (HP:0008316)3.91055269
20Potter facies (HP:0002009)3.89521994
21Facial shape deformation (HP:0011334)3.89521994
22Hypophosphatemic rickets (HP:0004912)3.85767298
23Eczematoid dermatitis (HP:0000976)3.81661740
24Mitral stenosis (HP:0001718)3.81583494
25Myocardial infarction (HP:0001658)3.80433668
26Recurrent fungal infections (HP:0002841)3.76067117
27Subacute progressive viral hepatitis (HP:0006572)3.72854314
28Vascular calcification (HP:0004934)3.70576862
29J-shaped sella turcica (HP:0002680)3.66818802
30Recurrent gram-negative bacterial infections (HP:0005420)3.58148910
31Aplasia/Hypoplasia of the thymus (HP:0010515)3.56496685
32Bundle branch block (HP:0011710)3.52418664
33Vacuolated lymphocytes (HP:0001922)3.49740485
34Cardiovascular calcification (HP:0011915)3.40283984
35Cerebral edema (HP:0002181)3.27628043
36Meningitis (HP:0001287)3.26787928
37Round ear (HP:0100830)3.15647203
38IgG deficiency (HP:0004315)3.13276210
39Complement deficiency (HP:0004431)3.10833394
40Stenosis of the external auditory canal (HP:0000402)3.10679990
41Hyporeflexia of lower limbs (HP:0002600)3.08357930
42Leukocytosis (HP:0001974)3.08250821
43Wrist flexion contracture (HP:0001239)3.07738451
44Choreoathetosis (HP:0001266)3.03597172
45Stomach cancer (HP:0012126)2.95838131
46Choroideremia (HP:0001139)2.90948973
47Ventricular tachycardia (HP:0004756)2.90865001
48Ventricular fibrillation (HP:0001663)2.90614177
49Chronic sinusitis (HP:0011109)2.90155173
50Muscle fiber splitting (HP:0003555)2.87536803
51Leukodystrophy (HP:0002415)2.82056714
52Abnormality of T cells (HP:0002843)2.80660566
53Mitochondrial inheritance (HP:0001427)2.80251629
54Sepsis (HP:0100806)2.80049636
55Abnormality of the thymus (HP:0000777)2.79158782
56Subaortic stenosis (HP:0001682)2.76480412
57Abnormality of the left ventricular outflow tract (HP:0011103)2.76480412
58Cellulitis (HP:0100658)2.71343920
59Abnormality of the fovea (HP:0000493)2.70173542
60Azoospermia (HP:0000027)2.69110860
61Right ventricular cardiomyopathy (HP:0011663)2.67673326
62Atrial fibrillation (HP:0005110)2.62203614
63Widely patent fontanelles and sutures (HP:0004492)2.60984709
64Neurofibrillary tangles (HP:0002185)2.60209511
65Hepatocellular carcinoma (HP:0001402)2.56123793
66Asymmetric septal hypertrophy (HP:0001670)2.55436520
67Hamartoma of the eye (HP:0010568)2.55069189
68Male infertility (HP:0003251)2.52056613
69Lower limb asymmetry (HP:0100559)2.51826647
70Syncope (HP:0001279)2.49129810
71Biliary tract neoplasm (HP:0100574)2.46562924
72Bone cyst (HP:0012062)2.45530355
73Abnormal rod and cone electroretinograms (HP:0008323)2.45105167
74Cerebral inclusion bodies (HP:0100314)2.44083155
75Large earlobe (HP:0009748)2.39593918
76Primary atrial arrhythmia (HP:0001692)2.39504903
77Rickets (HP:0002748)2.39267123
78Acute lymphatic leukemia (HP:0006721)2.38615804
79Abnormality of complement system (HP:0005339)2.38346206
80Malnutrition (HP:0004395)2.36539371
81Micronodular cirrhosis (HP:0001413)2.36330988
82Hypoplasia of the uterus (HP:0000013)2.34285059
83Supraventricular tachycardia (HP:0004755)2.31649911
84Heart block (HP:0012722)2.29351805
85Lipoatrophy (HP:0100578)2.28390887
86Megalencephaly (HP:0001355)2.28142243
87Abnormal spermatogenesis (HP:0008669)2.25845363
88Supraventricular arrhythmia (HP:0005115)2.25715801
89X-linked dominant inheritance (HP:0001423)2.25225762
90Supranuclear gaze palsy (HP:0000605)2.22601075
91Atrioventricular block (HP:0001678)2.21671381
92Distal lower limb muscle weakness (HP:0009053)2.20929642
93Respiratory failure (HP:0002878)2.19887691
94Intention tremor (HP:0002080)2.19182982
95Abnormal atrioventricular conduction (HP:0005150)2.17715367
96Progressive inability to walk (HP:0002505)2.15870414
97Increased CSF lactate (HP:0002490)2.15781438
98Abnormality of the calf musculature (HP:0001430)2.13776972
99Hematochezia (HP:0002573)2.10254931
100Abnormality of the tricuspid valve (HP:0001702)2.06323903
101Conjugated hyperbilirubinemia (HP:0002908)2.06114258
102Ventricular arrhythmia (HP:0004308)2.05513050
103Deep venous thrombosis (HP:0002625)2.04910994
104Macular degeneration (HP:0000608)2.04717818
105Recurrent bronchitis (HP:0002837)2.03853822
106Aortic aneurysm (HP:0004942)2.03032169
107Verrucae (HP:0200043)2.02557696
108Papilloma (HP:0012740)2.02557696
109Hypothermia (HP:0002045)2.01809143
110Spontaneous hematomas (HP:0007420)2.01088479
111B lymphocytopenia (HP:0010976)11.7867387
112Abnormality of B cell number (HP:0010975)10.5466614
113Hypoplasia of the thymus (HP:0000778)10.3864779
114Panhypogammaglobulinemia (HP:0003139)10.3721160
115Polar cataract (HP:0010696)1.99900042
116Lethargy (HP:0001254)1.99751533
117Alveolar cell carcinoma (HP:0006519)1.98355143
118Colitis (HP:0002583)1.97963299
119Overgrowth (HP:0001548)1.93389374
120Loss of speech (HP:0002371)1.91169531
121EMG: neuropathic changes (HP:0003445)1.91027597
122Agitation (HP:0000713)1.90624244
123Hemiplegia (HP:0002301)1.90171740
124Intrahepatic cholestasis (HP:0001406)1.90113788
125Abnormality of purine metabolism (HP:0004352)1.89759074
126Proximal tubulopathy (HP:0000114)1.87729348
127Upper limb muscle weakness (HP:0003484)1.87135427
128Distal lower limb amyotrophy (HP:0008944)1.86343382
129Abnormal hair laboratory examination (HP:0003328)1.85741300
130Hepatic necrosis (HP:0002605)1.85512937
131Psychosis (HP:0000709)1.85354202
132Wide cranial sutures (HP:0010537)1.85163099
133Exercise intolerance (HP:0003546)1.82875871
134Dilated cardiomyopathy (HP:0001644)1.81284717
135Rimmed vacuoles (HP:0003805)1.80589293
136Type 1 muscle fiber predominance (HP:0003803)1.80589256
137Hyperphosphatemia (HP:0002905)1.79450462
138Hypophosphatemia (HP:0002148)1.79318846
139Neoplasm of the tracheobronchial system (HP:0100552)1.79128050
140Abnormality of abdominal situs (HP:0011620)1.78820615
141Abdominal situs inversus (HP:0003363)1.78820615
142Neoplasm of the rectum (HP:0100743)1.78475919
143Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.77706626
144Abnormality of alanine metabolism (HP:0010916)1.77706626
145Hyperalaninemia (HP:0003348)1.77706626
146Bony spicule pigmentary retinopathy (HP:0007737)1.74891634
147Menorrhagia (HP:0000132)1.74802666
148Abnormality of sulfur amino acid metabolism (HP:0004339)1.74222634
149Anxiety (HP:0000739)1.72591604
150Infantile muscular hypotonia (HP:0008947)1.70782827
151Subcapsular cataract (HP:0000523)1.70080773
152Gastrointestinal dysmotility (HP:0002579)1.68783860
153EMG: myopathic abnormalities (HP:0003458)1.68413056
154Hyperphosphaturia (HP:0003109)1.68103964
155Abnormality of urine glucose concentration (HP:0011016)1.67888403
156Glycosuria (HP:0003076)1.67888403
157Aplasia/hypoplasia of the uterus (HP:0008684)1.67546667
158Deformed sella turcica (HP:0002681)1.66990536
159Thin bony cortex (HP:0002753)1.61562617
160Increased variability in muscle fiber diameter (HP:0003557)1.61373774
161Abnormality of aromatic amino acid family metabolism (HP:0004338)1.61118951
162Hypopigmentation of the fundus (HP:0007894)1.60948888
163Areflexia of lower limbs (HP:0002522)1.59940423
164Calf muscle hypertrophy (HP:0008981)1.54954955
165Neck muscle weakness (HP:0000467)1.53859555
166Increased connective tissue (HP:0009025)1.53512488
167Palpitations (HP:0001962)1.53481817
168Abnormality of skeletal muscle fiber size (HP:0012084)1.51531189
169Lymphoma (HP:0002665)1.51507803
170Mildly elevated creatine phosphokinase (HP:0008180)1.49791762
171Osteomyelitis (HP:0002754)1.48867380
172Exercise-induced myalgia (HP:0003738)1.46498734
173Difficulty running (HP:0009046)1.46130771
174Abnormality of the fingertips (HP:0001211)1.43913276
175Recurrent pneumonia (HP:0006532)1.43498541
176Muscle hypertrophy of the lower extremities (HP:0008968)1.42081398
177Esophageal varix (HP:0002040)1.41618086
178Cellular immunodeficiency (HP:0005374)1.41348526
179Periauricular skin pits (HP:0100277)1.40296455
180Preauricular pit (HP:0004467)1.40296455
181Polycythemia (HP:0001901)1.39951510
182Polygenic inheritance (HP:0010982)1.36317785
183Broad face (HP:0000283)1.36133803
184Papilledema (HP:0001085)1.35846985
185Abnormality of the foot musculature (HP:0001436)1.35731762
186Pruritus (HP:0000989)1.33449861
187Obstructive sleep apnea (HP:0002870)1.32393363
188Testicular neoplasm (HP:0010788)1.31394162
189Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.29913938
190Thyroid-stimulating hormone excess (HP:0002925)1.29841323
191Recurrent lower respiratory tract infections (HP:0002783)1.29105765
192Mesangial abnormality (HP:0001966)1.28977545
193Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.27957237
194Muscle fiber inclusion bodies (HP:0100299)1.27370614
195Stroke (HP:0001297)1.27063494
196Abnormality of the columella (HP:0009929)1.26755363
197Prolonged QT interval (HP:0001657)1.23688059
198Genetic anticipation (HP:0003743)1.22218319
199Bulbar palsy (HP:0001283)1.21935587

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.81796582
2LMTK23.46320843
3MET3.44037754
4KDR3.34328398
5NEK23.33440584
6ERN13.17656415
7MAP3K103.14239300
8PDK42.88132488
9PDK32.88132488
10MAP3K132.82270697
11IRAK32.81569186
12TIE12.58199602
13MAP3K62.51817634
14MAP3K72.49908678
15PKN22.47250726
16NUAK12.47168981
17KIT2.46094773
18PIK3CG2.30886865
19FES2.26337695
20NME22.24427552
21PRKD32.10628617
22BLK2.05767042
23OBSCN2.03358387
24CDK191.96853642
25DMPK1.71292305
26MARK21.65966846
27FGFR41.65268606
28TTK1.63383510
29PRKCH1.62968901
30TAOK31.58638577
31EPHB11.53830649
32TGFBR11.52957942
33BCKDK1.52506667
34MAPK121.51297291
35CDC42BPA1.50475434
36PDGFRA1.49751678
37PDK21.49512943
38RPS6KC11.43553400
39RPS6KL11.43553400
40FGFR21.42992786
41PRPF4B1.39862179
42EIF2AK11.37349918
43STK391.35570369
44RPS6KA61.28210485
45NLK1.24512189
46MAPK71.22983120
47MAPK41.22437259
48RIPK11.22339819
49TNK21.22192342
50NTRK31.18698476
51STK31.16647993
52FRK1.12908952
53SIK11.12455909
54EIF2AK31.02511985
55TEC1.02363374
56FLT31.02048087
57CSK1.01908684
58TRIB30.99563872
59TBK10.97407634
60LRRK20.96402927
61BTK0.93851619
62INSR0.93609187
63CDK60.91656817
64FER0.91530103
65PRKAA20.90098714
66ALK0.88952750
67JAK30.87937970
68EPHA20.85952508
69BMPR1B0.85925930
70SYK0.85110921
71LCK0.84056064
72CAMK40.83820455
73EPHA30.83156491
74PIK3CA0.82828742
75MAP2K30.82070190
76EIF2AK20.81848157
77HCK0.80427654
78PRKG20.79381349
79WNK10.79150438
80EEF2K0.78753259
81PINK10.77045866
82RIPK40.76593324
83CDK80.75196782
84LYN0.74801960
85RPS6KA20.74074893
86IKBKE0.72516200
87FYN0.71567312
88WNK40.71175240
89PDK10.71024821
90MYLK0.70827682
91RPS6KB10.70350308
92CAMK10.69230439
93MAP3K50.68778108
94PRKCG0.68272180
95HIPK20.67945007
96MAP3K10.67589893
97MAP3K140.66474304
98CDK90.63139911
99CSF1R0.60501797
100PRKD10.60430911
101TXK0.59531347
102STK110.58935042
103TYRO30.58931278
104EPHA40.58361962
105CAMK2D0.55761960
106PRKAA10.55296363
107SRC0.54649632
108PIM10.54336330
109PRKCD0.52858904
110MARK30.52692115
111TESK10.52508316
112SGK20.51355599
113DAPK20.50045301
114ZAP700.49956926
115GRK60.49722731
116JAK20.49151043
117ITK0.49129408
118PRKCQ0.49116538
119IGF1R0.48110036
120TTN0.47243330
121FGFR10.46225148
122NEK90.45183454
123SCYL20.44968337
124MAPK30.44244919
125CHUK0.42681539
126GRK70.42318641
127CDK120.41627050
128LATS20.41491695
129RET0.41428189
130STK40.40935995
131PTK60.39729796
132PDPK10.39643656
133DDR20.39130955
134MAP3K30.38687428
135TGFBR20.38595694
136PTK2B0.38471244
137ROCK10.37464953
138ERBB20.36785804
139MAP4K10.36749758
140OXSR10.36397359
141TYK20.35424946
142TESK20.34889539
143PBK0.34713219
144ABL10.33865539
145EGFR0.33269373
146PRKCA0.32989803
147MAPK10.32452010
148CDK30.31659373
149FGFR30.30947444
150PRKACG0.30805238
151PRKD20.30618018
152CDK50.29798001
153CDK40.29596036
154GSK3A0.29423749
155PRKCZ0.28549463
156NTRK10.27987467
157PRKACA0.27568836
158JAK10.26139856
159MAP3K120.24608084
160GRK10.24105360
161ILK0.23040658
162STK380.21074277
163TRPM70.20699750
164PAK40.20561156
165CSNK1E0.19958889

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.05057820
2Glutathione metabolism_Homo sapiens_hsa004804.36572450
3Non-homologous end-joining_Homo sapiens_hsa034504.28418778
4Tryptophan metabolism_Homo sapiens_hsa003803.79307802
5Arachidonic acid metabolism_Homo sapiens_hsa005903.45284858
6African trypanosomiasis_Homo sapiens_hsa051433.28342589
7Thyroid hormone synthesis_Homo sapiens_hsa049183.23278825
8Dilated cardiomyopathy_Homo sapiens_hsa054142.78341978
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.64200088
10Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.46230999
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.41417672
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.40122815
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.19167069
14B cell receptor signaling pathway_Homo sapiens_hsa046622.16715259
15Caffeine metabolism_Homo sapiens_hsa002322.11751982
16Asthma_Homo sapiens_hsa053101.87034096
17Fatty acid degradation_Homo sapiens_hsa000711.84742168
18Hematopoietic cell lineage_Homo sapiens_hsa046401.76909406
19Fatty acid metabolism_Homo sapiens_hsa012121.71586453
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.71240864
21FoxO signaling pathway_Homo sapiens_hsa040681.54849120
22Arginine biosynthesis_Homo sapiens_hsa002201.52224251
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.51090389
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.50590748
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.45774696
26Autoimmune thyroid disease_Homo sapiens_hsa053201.44864753
27Sulfur metabolism_Homo sapiens_hsa009201.38193441
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.37398848
29Allograft rejection_Homo sapiens_hsa053301.35772956
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.32247802
31Salivary secretion_Homo sapiens_hsa049701.29633530
32Insulin resistance_Homo sapiens_hsa049311.28466139
33Leishmaniasis_Homo sapiens_hsa051401.28025766
34Propanoate metabolism_Homo sapiens_hsa006401.27741912
35Graft-versus-host disease_Homo sapiens_hsa053321.27334225
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24205523
37beta-Alanine metabolism_Homo sapiens_hsa004101.23243757
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.20592764
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.19838944
40Phospholipase D signaling pathway_Homo sapiens_hsa040721.19390777
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.19174903
42PPAR signaling pathway_Homo sapiens_hsa033201.17497915
43Acute myeloid leukemia_Homo sapiens_hsa052211.16604685
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.13082056
45Butanoate metabolism_Homo sapiens_hsa006501.12130682
46Glycerolipid metabolism_Homo sapiens_hsa005611.10949386
47Toxoplasmosis_Homo sapiens_hsa051451.10560077
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.06476544
49Oxidative phosphorylation_Homo sapiens_hsa001901.05996558
50Leukocyte transendothelial migration_Homo sapiens_hsa046701.05606189
51Chronic myeloid leukemia_Homo sapiens_hsa052201.04890048
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03282490
53Osteoclast differentiation_Homo sapiens_hsa043800.99639957
54Pyruvate metabolism_Homo sapiens_hsa006200.98438089
55Adipocytokine signaling pathway_Homo sapiens_hsa049200.98370702
56Complement and coagulation cascades_Homo sapiens_hsa046100.96332503
57Gastric acid secretion_Homo sapiens_hsa049710.95064231
58Phenylalanine metabolism_Homo sapiens_hsa003600.93990513
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.93268815
60Starch and sucrose metabolism_Homo sapiens_hsa005000.92544062
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.89821923
62Other glycan degradation_Homo sapiens_hsa005110.88280865
63Malaria_Homo sapiens_hsa051440.88005735
64Renal cell carcinoma_Homo sapiens_hsa052110.87773404
65Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87133640
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.87036781
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86763206
68Ovarian steroidogenesis_Homo sapiens_hsa049130.85823825
69Bile secretion_Homo sapiens_hsa049760.84931438
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84829485
71mTOR signaling pathway_Homo sapiens_hsa041500.84389957
72RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84060777
73Arginine and proline metabolism_Homo sapiens_hsa003300.83519841
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82917353
75Influenza A_Homo sapiens_hsa051640.80406395
76Jak-STAT signaling pathway_Homo sapiens_hsa046300.78761094
77Focal adhesion_Homo sapiens_hsa045100.78662763
78Dorso-ventral axis formation_Homo sapiens_hsa043200.78216070
79HTLV-I infection_Homo sapiens_hsa051660.74815327
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.73768200
81Oxytocin signaling pathway_Homo sapiens_hsa049210.72455003
82Type I diabetes mellitus_Homo sapiens_hsa049400.72229443
83Alzheimers disease_Homo sapiens_hsa050100.71986064
84Staphylococcus aureus infection_Homo sapiens_hsa051500.70517927
85Renin secretion_Homo sapiens_hsa049240.70433353
86Pancreatic cancer_Homo sapiens_hsa052120.70055091
87Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69014884
88T cell receptor signaling pathway_Homo sapiens_hsa046600.68885471
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.67126439
90Primary immunodeficiency_Homo sapiens_hsa053400.65522396
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63070900
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62733645
93Chemical carcinogenesis_Homo sapiens_hsa052040.62718493
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62469345
95Parkinsons disease_Homo sapiens_hsa050120.61915803
96Insulin signaling pathway_Homo sapiens_hsa049100.61838004
97GnRH signaling pathway_Homo sapiens_hsa049120.61781672
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61774259
99Ribosome_Homo sapiens_hsa030100.61389545
100Pertussis_Homo sapiens_hsa051330.60690068
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60580185
102Folate biosynthesis_Homo sapiens_hsa007900.60299592
103Tuberculosis_Homo sapiens_hsa051520.60220245
104Linoleic acid metabolism_Homo sapiens_hsa005910.59605097
105cAMP signaling pathway_Homo sapiens_hsa040240.59437552
106Long-term potentiation_Homo sapiens_hsa047200.58634238
107GABAergic synapse_Homo sapiens_hsa047270.58346666
108Vibrio cholerae infection_Homo sapiens_hsa051100.57404256
109Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57064269
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56259996
111Herpes simplex infection_Homo sapiens_hsa051680.56243606
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.55500959
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55478052
114Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55316764
115ECM-receptor interaction_Homo sapiens_hsa045120.55274223
116Antigen processing and presentation_Homo sapiens_hsa046120.54734497
117Carbon metabolism_Homo sapiens_hsa012000.54602263
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52920475
119Prolactin signaling pathway_Homo sapiens_hsa049170.51079618
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50864175
121Estrogen signaling pathway_Homo sapiens_hsa049150.50425194
122NF-kappa B signaling pathway_Homo sapiens_hsa040640.50077408
123Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49612589
124Circadian entrainment_Homo sapiens_hsa047130.49393504
125Non-small cell lung cancer_Homo sapiens_hsa052230.47842917
126Sulfur relay system_Homo sapiens_hsa041220.47491094
127NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47178943
128Lysosome_Homo sapiens_hsa041420.47120691
129Selenocompound metabolism_Homo sapiens_hsa004500.47108419
130Glycosaminoglycan degradation_Homo sapiens_hsa005310.46523220
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.46436409
132Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45743474
133Pancreatic secretion_Homo sapiens_hsa049720.45557376
134Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45554487
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45452442
136Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44770563
137Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44714413
138Biosynthesis of amino acids_Homo sapiens_hsa012300.43952315
139Type II diabetes mellitus_Homo sapiens_hsa049300.42866440
140Notch signaling pathway_Homo sapiens_hsa043300.42798037
141Small cell lung cancer_Homo sapiens_hsa052220.42423495
142Toll-like receptor signaling pathway_Homo sapiens_hsa046200.41353397
143ABC transporters_Homo sapiens_hsa020100.40510536
144Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40458415
145Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39775524
146Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39348831
147Hepatitis C_Homo sapiens_hsa051600.38670574
148Glutamatergic synapse_Homo sapiens_hsa047240.37488111
149Chemokine signaling pathway_Homo sapiens_hsa040620.37411687
150Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37087485
151Hepatitis B_Homo sapiens_hsa051610.36644422
152Vascular smooth muscle contraction_Homo sapiens_hsa042700.36036471
153Measles_Homo sapiens_hsa051620.35974690
154Histidine metabolism_Homo sapiens_hsa003400.35816597
155Choline metabolism in cancer_Homo sapiens_hsa052310.35491913
156Tyrosine metabolism_Homo sapiens_hsa003500.35455688
157Olfactory transduction_Homo sapiens_hsa047400.33932222
158Morphine addiction_Homo sapiens_hsa050320.33532995
159Cholinergic synapse_Homo sapiens_hsa047250.32960294
160Platelet activation_Homo sapiens_hsa046110.32760361
161Fat digestion and absorption_Homo sapiens_hsa049750.32473263
162Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32309707
163Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.31850567
164Cysteine and methionine metabolism_Homo sapiens_hsa002700.30984988
165Insulin secretion_Homo sapiens_hsa049110.29795265
166Calcium signaling pathway_Homo sapiens_hsa040200.29597033
167VEGF signaling pathway_Homo sapiens_hsa043700.28233133
168Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.26951077
169Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26526140
170Amphetamine addiction_Homo sapiens_hsa050310.26105394
171Protein export_Homo sapiens_hsa030600.25746905
172Cardiac muscle contraction_Homo sapiens_hsa042600.25657212
173N-Glycan biosynthesis_Homo sapiens_hsa005100.25619792
174Viral myocarditis_Homo sapiens_hsa054160.25226378

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