LCN8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the lipocalin family, such as LCN8, have a common structure consisting of an 8-stranded antiparallel beta-barrel that forms a cup-shaped ligand-binding pocket or calyx. Lipocalins generally bind small hydrophobic ligands and transport them to specific cells (Suzuki et al., 2004 [PubMed 15363845]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of chronic inflammatory response (GO:0002676)9.01008112
2tryptophan catabolic process (GO:0006569)8.57802443
3indole-containing compound catabolic process (GO:0042436)8.57802443
4indolalkylamine catabolic process (GO:0046218)8.57802443
5single fertilization (GO:0007338)8.52454001
6heterotypic cell-cell adhesion (GO:0034113)8.45395031
7B cell receptor signaling pathway (GO:0050853)7.84886507
8negative regulation of interleukin-10 production (GO:0032693)7.38676994
9positive regulation of type 2 immune response (GO:0002830)7.38504108
10tryptophan metabolic process (GO:0006568)7.38216984
11regulation of antigen processing and presentation of peptide antigen (GO:0002583)7.04800322
12regulation of B cell receptor signaling pathway (GO:0050855)5.98891976
13aromatic amino acid family catabolic process (GO:0009074)5.92818309
14positive regulation of interferon-gamma biosynthetic process (GO:0045078)5.83999509
15defense response to protozoan (GO:0042832)5.78738397
16antigen processing and presentation of endogenous antigen (GO:0019883)5.65327663
17fertilization (GO:0009566)5.61898617
18regulation of interferon-beta biosynthetic process (GO:0045357)5.59103750
19amine catabolic process (GO:0009310)5.51977833
20cellular biogenic amine catabolic process (GO:0042402)5.51977833
21indolalkylamine metabolic process (GO:0006586)5.41366459
22regulation of germinal center formation (GO:0002634)5.28986448
23negative regulation of interleukin-8 production (GO:0032717)5.20695879
24regulation of antigen processing and presentation (GO:0002577)5.13768825
25positive thymic T cell selection (GO:0045059)4.92343660
26benzene-containing compound metabolic process (GO:0042537)4.84508642
27negative regulation of T-helper cell differentiation (GO:0045623)4.81340924
28negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.81340924
29response to protozoan (GO:0001562)4.78227985
30positive regulation of Rap GTPase activity (GO:0032854)4.74923721
31positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.70681520
32digestion (GO:0007586)4.58550926
33antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.52898270
34positive regulation of gamma-delta T cell activation (GO:0046645)4.47102990
35regulation of interferon-gamma biosynthetic process (GO:0045072)4.46214496
36regulation of dendritic cell antigen processing and presentation (GO:0002604)4.39660899
37negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.37488273
38hydrogen peroxide biosynthetic process (GO:0050665)4.36782308
39regulation of T-helper 2 cell differentiation (GO:0045628)4.34577407
40epithelial cell morphogenesis (GO:0003382)4.34012698
41negative regulation of T cell apoptotic process (GO:0070233)4.33028500
42negative regulation of endopeptidase activity (GO:0010951)4.32760494
43respiratory burst (GO:0045730)4.28764689
44aromatic amino acid family metabolic process (GO:0009072)4.28679058
45positive regulation of cell-cell adhesion (GO:0022409)4.28655274
46neutrophil activation involved in immune response (GO:0002283)4.26995738
47histone H3-K36 demethylation (GO:0070544)4.22190216
48immunoglobulin mediated immune response (GO:0016064)4.19975328
49positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.19684626
50negative regulation of peptidase activity (GO:0010466)4.13325147
51antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.10974206
52negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.08131591
53negative regulation of cell killing (GO:0031342)4.08131591
54regulation of mast cell degranulation (GO:0043304)4.07812902
55antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.06804737
56antigen receptor-mediated signaling pathway (GO:0050851)4.06383961
57regulation of Rap GTPase activity (GO:0032317)4.01390548
58positive regulation of mast cell degranulation (GO:0043306)3.99750671
59positive regulation of mast cell activation involved in immune response (GO:0033008)3.99750671
60negative regulation of calcium ion transport into cytosol (GO:0010523)3.95636863
61regulation of B cell differentiation (GO:0045577)3.95075964
62transepithelial transport (GO:0070633)3.95070274
63detection of bacterium (GO:0016045)3.92337540
64B cell homeostasis (GO:0001782)3.90586158
65positive regulation of chemokine secretion (GO:0090197)3.89503045
66indole-containing compound metabolic process (GO:0042430)3.87370537
67reactive oxygen species biosynthetic process (GO:1903409)3.87206047
68regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.85801140
69regulation of type 2 immune response (GO:0002828)3.84271621
70positive regulation of antigen processing and presentation (GO:0002579)3.82582262
71CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.74923052
72reverse cholesterol transport (GO:0043691)3.73957978
73regulation of mast cell activation involved in immune response (GO:0033006)3.72540724
74regulation of clathrin-mediated endocytosis (GO:2000369)3.72110812
75positive T cell selection (GO:0043368)3.68339730
76positive regulation of B cell differentiation (GO:0045579)3.67959482
77negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.66154312
78sulfur amino acid catabolic process (GO:0000098)3.65675735
79detection of other organism (GO:0098543)3.63648649
80protein-chromophore linkage (GO:0018298)3.61194626
81regulation of platelet aggregation (GO:0090330)3.60944268
82positive regulation of B cell proliferation (GO:0030890)3.58520524
83thymic T cell selection (GO:0045061)3.53260226
84defense response to bacterium (GO:0042742)3.51464628
85multicellular organism reproduction (GO:0032504)3.49608405
86regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.45029622
87activation of Rac GTPase activity (GO:0032863)3.44456055
88positive regulation of mast cell activation (GO:0033005)3.41186610
89regulation of gamma-delta T cell differentiation (GO:0045586)3.40856680
90B cell proliferation (GO:0042100)3.40302727
91regulation of gamma-delta T cell activation (GO:0046643)3.39351594
92T cell selection (GO:0045058)3.38483888
93interferon-gamma-mediated signaling pathway (GO:0060333)3.36707798
94N-acetylneuraminate metabolic process (GO:0006054)3.36337438
95T cell costimulation (GO:0031295)3.31018162
96positive regulation of CREB transcription factor activity (GO:0032793)3.30995771
97negative regulation of protein autophosphorylation (GO:0031953)3.30373144
98negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.29309134
99regulation of chemokine secretion (GO:0090196)3.29008695
100positive regulation of B cell activation (GO:0050871)3.27804587
101Arp2/3 complex-mediated actin nucleation (GO:0034314)3.26338710
102lymphocyte costimulation (GO:0031294)3.25943477
103phospholipid homeostasis (GO:0055091)3.25294027
104positive regulation of interferon-alpha production (GO:0032727)3.24565672
105regulation of myeloid leukocyte mediated immunity (GO:0002886)3.21784514
106negative regulation of cAMP-mediated signaling (GO:0043951)3.21734573
107neutrophil activation (GO:0042119)3.18827424
108alpha-linolenic acid metabolic process (GO:0036109)3.17614953
109fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.17229441
110regulation of T-helper 1 cell differentiation (GO:0045625)3.16457802
111regulation of leukocyte degranulation (GO:0043300)3.16425860
112megakaryocyte development (GO:0035855)3.16069458
113regulation of mast cell activation (GO:0033003)3.13674216
114leukocyte aggregation (GO:0070486)3.13128071
115regulation of B cell proliferation (GO:0030888)3.12055945
116poly(A)+ mRNA export from nucleus (GO:0016973)3.11867045
117macrophage activation involved in immune response (GO:0002281)3.10968461
118negative regulation of alpha-beta T cell activation (GO:0046636)3.10737483
119negative regulation of alpha-beta T cell differentiation (GO:0046639)3.07558582
120superoxide anion generation (GO:0042554)3.07437278
121response to type I interferon (GO:0034340)3.06754353
122cellular response to type I interferon (GO:0071357)3.06276570
123type I interferon signaling pathway (GO:0060337)3.06276570
124response to bacterium (GO:0009617)3.03893173
125granulocyte activation (GO:0036230)3.03484767
126regulation of ARF protein signal transduction (GO:0032012)3.01105653
127regulation of macrophage activation (GO:0043030)3.00936675
128negative thymic T cell selection (GO:0045060)3.00085526
129seminiferous tubule development (GO:0072520)24.8672600
130regulation of interferon-alpha production (GO:0032647)2.99641042
131regulation of lipoprotein metabolic process (GO:0050746)2.99255286
132B cell mediated immunity (GO:0019724)2.98786460
133negative regulation of phagocytosis (GO:0050765)2.98095153
134diacylglycerol metabolic process (GO:0046339)2.97958229
135lymphocyte homeostasis (GO:0002260)2.96192207
136positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.94370690
137cysteine metabolic process (GO:0006534)2.81580081
138negative regulation of proteolysis (GO:0045861)2.79034828
139glial cell proliferation (GO:0014009)2.77912501
140complement activation, alternative pathway (GO:0006957)2.76756182
141high-density lipoprotein particle remodeling (GO:0034375)2.73930896
142regulation of beta-amyloid formation (GO:1902003)2.70945945
143regulation of activated T cell proliferation (GO:0046006)2.70670789
144sialylation (GO:0097503)2.70086882
145negative regulation of protein processing (GO:0010955)2.69268985
146negative regulation of protein maturation (GO:1903318)2.69268985
147negative regulation of glycogen biosynthetic process (GO:0045719)2.68960121
148O-glycan processing (GO:0016266)2.66473694
149negative regulation of lymphocyte apoptotic process (GO:0070229)2.64408582
150positive regulation of cellular amide metabolic process (GO:0034250)2.58839660
151low-density lipoprotein particle clearance (GO:0034383)2.58037226
152positive regulation of interleukin-12 production (GO:0032735)2.56247761
153hormone catabolic process (GO:0042447)2.56228775
154negative regulation of hydrolase activity (GO:0051346)2.50827653
155columnar/cuboidal epithelial cell development (GO:0002066)2.48443869
156negative regulation of receptor-mediated endocytosis (GO:0048261)2.47937243
157regulation of amyloid precursor protein catabolic process (GO:1902991)2.44646377
158negative regulation of glycogen metabolic process (GO:0070874)2.44210383
159alpha-amino acid catabolic process (GO:1901606)2.39945291
160valine metabolic process (GO:0006573)2.37051814
161L-serine transport (GO:0015825)2.33527525
162erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.32073906
163L-phenylalanine catabolic process (GO:0006559)2.32073906
164lipid catabolic process (GO:0016042)2.32003550
165cellular amino acid catabolic process (GO:0009063)2.31681000
166regulation of endopeptidase activity (GO:0052548)2.31511749
167pyrimidine ribonucleoside catabolic process (GO:0046133)2.28950806
168triglyceride catabolic process (GO:0019433)2.26320740
169negative regulation of interleukin-6 production (GO:0032715)2.23104470
170response to misfolded protein (GO:0051788)2.22442496
171protein-lipid complex remodeling (GO:0034368)2.21091454
172macromolecular complex remodeling (GO:0034367)2.21091454
173plasma lipoprotein particle remodeling (GO:0034369)2.21091454
174neutral lipid catabolic process (GO:0046461)2.20562865
175acylglycerol catabolic process (GO:0046464)2.20562865
176regulation of T cell apoptotic process (GO:0070232)2.20370262
177regulation of peptidase activity (GO:0052547)2.20111317
178cellular modified amino acid catabolic process (GO:0042219)2.14057644
179positive regulation of cholesterol transport (GO:0032376)2.12971255
180positive regulation of sterol transport (GO:0032373)2.12971255
181regulation of lipoprotein particle clearance (GO:0010984)2.12002405
182glutamate metabolic process (GO:0006536)2.11763982
183Golgi transport vesicle coating (GO:0048200)2.09619766
184COPI coating of Golgi vesicle (GO:0048205)2.09619766
185regulation of interleukin-10 production (GO:0032653)2.09403310
186erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.08076324
187L-phenylalanine metabolic process (GO:0006558)2.08076324
188myelin maintenance (GO:0043217)2.07618245
189cellular response to epidermal growth factor stimulus (GO:0071364)2.05422475
190negative regulation of T cell proliferation (GO:0042130)2.03275724
191production of molecular mediator involved in inflammatory response (GO:0002532)14.2129523
192regulation of T cell tolerance induction (GO:0002664)14.2123451
193positive regulation of tolerance induction (GO:0002645)12.1835489
194sperm capacitation (GO:0048240)11.0510089
195regulation of tolerance induction (GO:0002643)10.6037061
196kynurenine metabolic process (GO:0070189)10.4695998

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.06333621
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human4.72001630
3MYC_22102868_ChIP-Seq_BL_Human4.42442015
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.10397642
5IKZF1_21737484_ChIP-ChIP_HCT116_Human3.96199171
6E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human3.75103493
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.33037229
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.19973136
9AR_21572438_ChIP-Seq_LNCaP_Human3.15597622
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.10134470
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.03131541
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.95828677
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.86832079
14EZH2_22144423_ChIP-Seq_EOC_Human2.79129220
15VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.78156355
16KDM2B_26808549_Chip-Seq_SUP-B15_Human2.64917783
17VDR_21846776_ChIP-Seq_THP-1_Human2.64814618
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.64602074
19CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.59846183
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.58179422
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.55021652
22IRF8_21731497_ChIP-ChIP_J774_Mouse2.53750378
23ESR1_21235772_ChIP-Seq_MCF-7_Human2.52658165
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.52319309
25ZNF263_19887448_ChIP-Seq_K562_Human2.47397525
26RXR_22158963_ChIP-Seq_LIVER_Mouse2.43949451
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.43870066
28MAF_26560356_Chip-Seq_TH1_Human2.38443287
29LXR_22158963_ChIP-Seq_LIVER_Mouse2.37475034
30GATA1_22025678_ChIP-Seq_K562_Human2.33289420
31UTX_26944678_Chip-Seq_JUKART_Human2.29089786
32CIITA_25753668_ChIP-Seq_RAJI_Human2.27011034
33SCL_19346495_ChIP-Seq_HPC-7_Human2.26959090
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.26461383
35KDM2B_26808549_Chip-Seq_DND41_Human2.24011827
36MYB_26560356_Chip-Seq_TH2_Human2.21772841
37DNAJC2_21179169_ChIP-ChIP_NT2_Human2.17700203
38RUNX_20019798_ChIP-Seq_JUKART_Human2.13918299
39TCF7_22412390_ChIP-Seq_EML_Mouse2.08755958
40MYB_26560356_Chip-Seq_TH1_Human2.08239466
41TRIM28_21343339_ChIP-Seq_HEK293_Human2.08021743
42SPI1_23127762_ChIP-Seq_K562_Human2.05614085
43ESR2_21235772_ChIP-Seq_MCF-7_Human2.05077767
44SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse2.04495976
45VDR_24763502_ChIP-Seq_THP-1_Human2.01022505
46CLOCK_20551151_ChIP-Seq_293T_Human2.00634368
47STAT6_21828071_ChIP-Seq_BEAS2B_Human2.00213178
48PPARA_22158963_ChIP-Seq_LIVER_Mouse1.95750297
49IRF8_27001747_Chip-Seq_BMDM_Mouse1.94230952
50SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.88103652
51BP1_19119308_ChIP-ChIP_Hs578T_Human1.87159791
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.86211072
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.84808236
54MAF_26560356_Chip-Seq_TH2_Human1.83737966
55GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.82744188
56SPI1_23547873_ChIP-Seq_NB4_Human1.79211509
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76966587
58IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.76236423
59EGR1_23403033_ChIP-Seq_LIVER_Mouse1.73844216
60GATA3_21867929_ChIP-Seq_TH1_Mouse1.72051002
61NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.66653341
62MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.66500750
63PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.65795530
64SMAD1_18555785_Chip-Seq_ESCs_Mouse1.61432053
65TET1_21451524_ChIP-Seq_MESCs_Mouse1.60983676
66REST_19997604_ChIP-ChIP_NEURONS_Mouse1.56151685
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54999562
68NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53924439
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53769373
70GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.52659391
71LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.51665265
72FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.51597023
73SMAD4_21741376_ChIP-Seq_HESCs_Human1.51156718
74EZH2_18974828_ChIP-Seq_MESCs_Mouse1.50776284
75RNF2_18974828_ChIP-Seq_MESCs_Mouse1.50776284
76SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50600861
77GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.48440689
78RAD21_21589869_ChIP-Seq_MESCs_Mouse1.48158309
79STAT1_17558387_ChIP-Seq_HELA_Human1.47639367
80STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.46290827
81LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.45636503
82CTCF_27219007_Chip-Seq_ERYTHROID_Human1.45498948
83FLI1_21867929_ChIP-Seq_CD8_Mouse1.45099953
84MYB_21317192_ChIP-Seq_ERMYB_Mouse1.43436837
85GATA3_27048872_Chip-Seq_THYMUS_Human1.42107298
86SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.38219051
87SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37321842
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36846926
89ESRRB_18555785_Chip-Seq_ESCs_Mouse1.36562899
90FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36423564
91TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.32396967
92SMAD3_21741376_ChIP-Seq_HESCs_Human1.31491987
93GATA1_19941827_ChIP-Seq_MEL_Mouse1.31402766
94NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29710283
95SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.29561939
96TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28163149
97TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27791582
98GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.27264640
99ELF1_20517297_ChIP-Seq_JURKAT_Human1.26692783
100SPI1_20517297_ChIP-Seq_HL60_Human1.26202989
101STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.25986378
102SA1_27219007_Chip-Seq_Bcells_Human1.25952043
103ELK3_25401928_ChIP-Seq_HUVEC_Human1.25839102
104STAT4_19710469_ChIP-ChIP_TH1__Mouse1.24605268
105CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22349383
106P68_20966046_ChIP-Seq_HELA_Human1.21806734
107CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21665283
108NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.21261644
109KDM2B_26808549_Chip-Seq_JURKAT_Human1.20111166
110PU.1_20513432_ChIP-Seq_Bcells_Mouse1.19733840
111E2F1_20622854_ChIP-Seq_HELA_Human1.18046679
112SA1_27219007_Chip-Seq_ERYTHROID_Human1.17456064
113SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.17021429
114MYC_27129775_Chip-Seq_CORNEA_Mouse1.15513324
115VDR_24787735_ChIP-Seq_THP-1_Human1.15200819
116SMC4_20622854_ChIP-Seq_HELA_Human1.14352787
117SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13879308
118RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.13105418
119CTCF_21964334_ChIP-Seq_BJAB-B_Human1.12795411
120PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11441412
121BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.10999943
122PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.10545638
123EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10334267
124EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.10223502
125BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10016845
126TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09716469
127SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09456188
128* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.08671124
129SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.07040040
130SALL4_22934838_ChIP-ChIP_CD34+_Human1.06933377
131BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.06216075
132BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05541587
133MTF2_20144788_ChIP-Seq_MESCs_Mouse1.04718902
134NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04050782
135NFE2_27457419_Chip-Seq_LIVER_Mouse1.03706933
136EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02854136
137GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02716463
138PHF8_20622854_ChIP-Seq_HELA_Human1.02692409
139SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.02028334
140FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01908961
141ELK4_26923725_Chip-Seq_MESODERM_Mouse1.00388562
142REST_18959480_ChIP-ChIP_MESCs_Mouse0.98845888
143NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.98629679
144SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.98299242
145CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97899155
146BCL6_27268052_Chip-Seq_Bcells_Human0.97662229
147ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97507729
148CBX2_27304074_Chip-Seq_ESCs_Mouse0.97414958
149FOXH1_21741376_ChIP-Seq_ESCs_Human0.97168423
150SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.97161767
151SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.96691770
152CTCF_27219007_Chip-Seq_Bcells_Human0.96005462
153DROSHA_22980978_ChIP-Seq_HELA_Human0.95885785
154EGR1_19032775_ChIP-ChIP_M12_Human0.95668421
155ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94955210
156CTCF_21964334_Chip-Seq_Bcells_Human0.94681725
157CTCF_26484167_Chip-Seq_Bcells_Mouse0.94564275
158TP53_20018659_ChIP-ChIP_R1E_Mouse0.94548036
159VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94370149
160BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94344104
161SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.93049103
162ERG_21242973_ChIP-ChIP_JURKAT_Human0.92887030
163KDM2B_26808549_Chip-Seq_REH_Human0.92037851
164EZH2_27304074_Chip-Seq_ESCs_Mouse0.91791589
165KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91755657
166ETS1_21867929_ChIP-Seq_TH2_Mouse0.91647970
167LXR_22292898_ChIP-Seq_THP-1_Human0.90909151
168KDM2B_26808549_Chip-Seq_K562_Human0.90582444
169EZH2_27294783_Chip-Seq_NPCs_Mouse0.86706571
170PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.86610635
171P300_27268052_Chip-Seq_Bcells_Human0.85498085
172BCOR_27268052_Chip-Seq_Bcells_Human0.85062562
173GATA1_19941826_ChIP-Seq_K562_Human0.84772512
174SOX2_18555785_Chip-Seq_ESCs_Mouse0.84772286
175SOX2_20726797_ChIP-Seq_SW620_Human0.84277159
176RAC3_21632823_ChIP-Seq_H3396_Human0.82766634
177WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.82438942
178* RACK7_27058665_Chip-Seq_MCF-7_Human0.81933610
179* CTCF_18555785_Chip-Seq_ESCs_Mouse0.81115855
180* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.79855375
181RUNX1_27457419_Chip-Seq_LIVER_Mouse0.79686753
182WT1_19549856_ChIP-ChIP_CCG9911_Human0.79547501

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation5.61325906
2MP0003195_calcinosis5.15686068
3MP0002254_reproductive_system_inflammat4.99426452
4MP0004043_abnormal_pH_regulation4.63843310
5MP0002139_abnormal_hepatobiliary_system4.27962695
6MP0010234_abnormal_vibrissa_follicle4.17438591
7MP0005387_immune_system_phenotype4.14295406
8MP0001790_abnormal_immune_system4.14295406
9MP0001800_abnormal_humoral_immune4.08189980
10MP0001835_abnormal_antigen_presentation3.78831056
11MP0003172_abnormal_lysosome_physiology3.56886884
12MP0005410_abnormal_fertilization3.24008257
13MP0005058_abnormal_lysosome_morphology3.11532667
14MP0003329_amyloid_beta_deposits3.02101820
15MP0002452_abnormal_antigen_presenting2.99554827
16MP0003436_decreased_susceptibility_to2.95653195
17MP0002723_abnormal_immune_serum2.90409471
18MP0005671_abnormal_response_to2.87812183
19MP0002420_abnormal_adaptive_immunity2.85178249
20MP0001819_abnormal_immune_cell2.78907592
21MP0002638_abnormal_pupillary_reflex2.77517066
22MP0005000_abnormal_immune_tolerance2.57735269
23MP0003763_abnormal_thymus_physiology2.40371471
24MP0002398_abnormal_bone_marrow2.33754911
25MP0005360_urolithiasis2.29699823
26MP0005025_abnormal_response_to2.28303362
27MP0005075_abnormal_melanosome_morpholog2.22472274
28MP0000003_abnormal_adipose_tissue2.22243095
29MP0003183_abnormal_peptide_metabolism2.17367647
30MP0000716_abnormal_immune_system2.14690773
31MP0009785_altered_susceptibility_to2.14432256
32MP0010329_abnormal_lipoprotein_level2.10975425
33MP0000689_abnormal_spleen_morphology2.08674534
34MP0000604_amyloidosis2.07508274
35MP0000685_abnormal_immune_system2.00665777
36MP0002419_abnormal_innate_immunity1.98506028
37MP0002168_other_aberrant_phenotype1.95223130
38MP0005365_abnormal_bile_salt1.94876035
39MP0004381_abnormal_hair_follicle1.91613194
40MP0001764_abnormal_homeostasis1.76173206
41MP0002148_abnormal_hypersensitivity_rea1.75712792
42MP0005310_abnormal_salivary_gland1.74359763
43MP0003300_gastrointestinal_ulcer1.73798867
44MP0003566_abnormal_cell_adhesion1.73393525
45MP0005085_abnormal_gallbladder_physiolo1.71357565
46MP0004885_abnormal_endolymph1.64552935
47MP0002429_abnormal_blood_cell1.62842052
48MP0002722_abnormal_immune_system1.61744420
49MP0001501_abnormal_sleep_pattern1.59195244
50MP0004130_abnormal_muscle_cell1.57725719
51MP0003724_increased_susceptibility_to1.57666381
52MP0005375_adipose_tissue_phenotype1.52793993
53MP0002837_dystrophic_cardiac_calcinosis1.51989210
54MP0001765_abnormal_ion_homeostasis1.50943063
55MP0003646_muscle_fatigue1.50725695
56MP0004859_abnormal_synaptic_plasticity1.47466708
57MP0001502_abnormal_circadian_rhythm1.45250985
58MP0001440_abnormal_grooming_behavior1.44741596
59MP0001853_heart_inflammation1.43720689
60MP0003690_abnormal_glial_cell1.39298909
61MP0002396_abnormal_hematopoietic_system1.37124380
62MP0000534_abnormal_ureter_morphology1.36262414
63MP0009643_abnormal_urine_homeostasis1.36105615
64MP0001873_stomach_inflammation1.35260812
65MP0003705_abnormal_hypodermis_morpholog1.34726140
66MP0004858_abnormal_nervous_system1.32395071
67MP0003787_abnormal_imprinting1.32323352
68MP0005332_abnormal_amino_acid1.32109244
69MP0005083_abnormal_biliary_tract1.31391919
70MP0002928_abnormal_bile_duct1.28825700
71MP0004185_abnormal_adipocyte_glucose1.26461401
72MP0010155_abnormal_intestine_physiology1.25740831
73MP0006138_congestive_heart_failure1.25081622
74MP0001845_abnormal_inflammatory_respons1.24571386
75MP0002405_respiratory_system_inflammati1.24382114
76MP0000372_irregular_coat_pigmentation1.23113449
77MP0002118_abnormal_lipid_homeostasis1.22067889
78MP0000465_gastrointestinal_hemorrhage1.19199579
79MP0000703_abnormal_thymus_morphology1.19016163
80MP0008438_abnormal_cutaneous_collagen1.17975685
81MP0005584_abnormal_enzyme/coenzyme_acti1.17836626
82MP0001986_abnormal_taste_sensitivity1.17174202
83MP0003806_abnormal_nucleotide_metabolis1.16773630
84MP0001756_abnormal_urination1.14789389
85MP0002089_abnormal_postnatal_growth/wei1.14113496
86MP0005451_abnormal_body_composition1.12905129
87MP0000537_abnormal_urethra_morphology1.12010661
88MP0008874_decreased_physiological_sensi1.11791951
89MP0003191_abnormal_cellular_cholesterol1.11766518
90MP0009333_abnormal_splenocyte_physiolog1.11100021
91MP0005275_abnormal_skin_tensile1.08999483
92MP0003252_abnormal_bile_duct1.08808074
93MP0002822_catalepsy1.08019549
94MP0008875_abnormal_xenobiotic_pharmacok1.06347853
95MP0002896_abnormal_bone_mineralization1.05710016
96MP0005464_abnormal_platelet_physiology1.05497115
97MP0009780_abnormal_chondrocyte_physiolo1.03377879
98MP0002796_impaired_skin_barrier1.02764187
99MP0004270_analgesia1.02731271
100MP0001849_ear_inflammation1.02708894
101MP0004084_abnormal_cardiac_muscle1.01179515
102MP0001533_abnormal_skeleton_physiology0.99669707
103MP0005636_abnormal_mineral_homeostasis0.98593742
104MP0008469_abnormal_protein_level0.98312284
105MP0003075_altered_response_to0.96463438
106MP0000015_abnormal_ear_pigmentation0.96251085
107MP0002876_abnormal_thyroid_physiology0.95115572
108MP0002909_abnormal_adrenal_gland0.94986245
109MP0004947_skin_inflammation0.94521017
110MP0003879_abnormal_hair_cell0.93448860
111MP0000920_abnormal_myelination0.93356745
112MP0002009_preneoplasia0.93327308
113MP0005645_abnormal_hypothalamus_physiol0.93147116
114MP0003632_abnormal_nervous_system0.93058174
115MP0005666_abnormal_adipose_tissue0.92029864
116MP0008961_abnormal_basal_metabolism0.90632687
117MP0003698_abnormal_male_reproductive0.88115493
118MP0001663_abnormal_digestive_system0.87927070
119MP0002733_abnormal_thermal_nociception0.86809222
120MP0002136_abnormal_kidney_physiology0.82114315
121MP0000609_abnormal_liver_physiology0.81253595
122MP0004742_abnormal_vestibular_system0.80312031
123MP0002735_abnormal_chemical_nociception0.80250025
124MP0000747_muscle_weakness0.79333192
125MP0004510_myositis0.79133684
126MP0004145_abnormal_muscle_electrophysio0.79124528
127MP0002933_joint_inflammation0.77836835
128MP0009278_abnormal_bone_marrow0.77370494
129MP0009745_abnormal_behavioral_response0.76851870
130MP0004036_abnormal_muscle_relaxation0.76378656
131MP0003631_nervous_system_phenotype0.75825652
132MP0003635_abnormal_synaptic_transmissio0.75509290
133MP0005319_abnormal_enzyme/_coenzyme0.75261096
134MP0003633_abnormal_nervous_system0.74336181
135MP0009840_abnormal_foam_cell0.74230669
136MP0002132_abnormal_respiratory_system0.73224259
137MP0005381_digestive/alimentary_phenotyp0.72107181
138MP0009764_decreased_sensitivity_to0.68356409
139MP0001851_eye_inflammation0.68012568
140MP0005670_abnormal_white_adipose0.67660790
141MP0005395_other_phenotype0.66749975
142MP0000733_abnormal_muscle_development0.66436497
143MP0004484_altered_response_of0.65925490
144MP0000538_abnormal_urinary_bladder0.65483548
145MP0005535_abnormal_body_temperature0.65063949
146MP0010678_abnormal_skin_adnexa0.64727259
147MP0005334_abnormal_fat_pad0.64602368
148MP0003866_abnormal_defecation0.63904791
149MP0002971_abnormal_brown_adipose0.63310372
150MP0001666_abnormal_nutrient_absorption0.63263987
151MP0002272_abnormal_nervous_system0.62599406
152MP0009384_cardiac_valve_regurgitation0.61668753
153MP0000462_abnormal_digestive_system0.61584792
154MP0003634_abnormal_glial_cell0.61202666
155MP0001970_abnormal_pain_threshold0.60378452
156MP0008569_lethality_at_weaning0.59363840
157MP0000249_abnormal_blood_vessel0.59189122
158MP0005623_abnormal_meninges_morphology0.59174125
159MP0002295_abnormal_pulmonary_circulatio0.59101890
160MP0008004_abnormal_stomach_pH0.58390403
161MP0009053_abnormal_anal_canal0.57971356
162MP0004142_abnormal_muscle_tone0.57379769
163MP0003959_abnormal_lean_body0.56397368
164MP0005423_abnormal_somatic_nervous0.54702220
165MP0000751_myopathy0.54651569
166MP0004272_abnormal_basement_membrane0.54592222
167MP0002166_altered_tumor_susceptibility0.54464577
168MP0002138_abnormal_hepatobiliary_system0.54060162
169MP0002064_seizures0.53664659
170MP0005166_decreased_susceptibility_to0.52911217
171MP0001905_abnormal_dopamine_level0.52511965
172MP0008877_abnormal_DNA_methylation0.52282637
173MP0002653_abnormal_ependyma_morphology0.51035492
174MP0000013_abnormal_adipose_tissue0.49986512
175MP0004087_abnormal_muscle_fiber0.49664454
176MP0005397_hematopoietic_system_phenotyp0.49084653
177MP0003656_abnormal_erythrocyte_physiolo0.48675952
178MP0001177_atelectasis0.48605469

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)9.14282558
2Cellulitis (HP:0100658)6.25643754
3Eczematoid dermatitis (HP:0000976)5.85083422
4Meningitis (HP:0001287)5.84052732
5Gastrointestinal stroma tumor (HP:0100723)5.66175752
6Myocardial infarction (HP:0001658)5.36288508
7Recurrent pneumonia (HP:0006532)5.18931963
8Verrucae (HP:0200043)5.16389447
9Papilloma (HP:0012740)5.16389447
10Hypophosphatemic rickets (HP:0004912)5.03207672
11Recurrent bronchitis (HP:0002837)4.99411482
12Recurrent sinusitis (HP:0011108)4.79125497
13Mediastinal lymphadenopathy (HP:0100721)4.75467596
14Potter facies (HP:0002009)4.72646720
15Facial shape deformation (HP:0011334)4.72646720
16Vascular calcification (HP:0004934)4.70874042
17Recurrent bacterial skin infections (HP:0005406)4.69456752
18Complement deficiency (HP:0004431)4.64314140
19Chronic obstructive pulmonary disease (HP:0006510)4.44918550
20Obstructive lung disease (HP:0006536)4.44918550
21Cardiovascular calcification (HP:0011915)4.39361402
22Osteomyelitis (HP:0002754)4.38034057
23Neurofibrillary tangles (HP:0002185)4.29143264
24Cerebral inclusion bodies (HP:0100314)4.16704017
25Recurrent lower respiratory tract infections (HP:0002783)4.09370400
26Chronic sinusitis (HP:0011109)4.07203866
27Recurrent abscess formation (HP:0002722)4.06810868
28Abnormality of macrophages (HP:0004311)4.05947961
29Obstructive sleep apnea (HP:0002870)4.01378041
30Panhypogammaglobulinemia (HP:0003139)3.97455544
31Malnutrition (HP:0004395)3.93897134
32Recurrent fungal infections (HP:0002841)3.85234739
33Colitis (HP:0002583)3.77619519
34Inflammation of the large intestine (HP:0002037)3.73855602
35Sepsis (HP:0100806)3.68876098
36Choroideremia (HP:0001139)3.66675420
37Lymphopenia (HP:0001888)3.66634855
38Restrictive lung disease (HP:0002091)3.65144790
39Vasculitis (HP:0002633)3.63337743
40Gastrointestinal inflammation (HP:0004386)3.62967543
41Neoplasm of the heart (HP:0100544)3.50154822
42Abnormality of complement system (HP:0005339)3.39291713
43Abnormal delayed hypersensitivity skin test (HP:0002963)3.33884680
44IgG deficiency (HP:0004315)3.33526878
45Xanthomatosis (HP:0000991)3.26440962
46Recurrent gram-negative bacterial infections (HP:0005420)3.22948726
47Recurrent viral infections (HP:0004429)3.20701749
48Deep venous thrombosis (HP:0002625)3.20160620
49Infantile muscular hypotonia (HP:0008947)3.18072736
50Supranuclear gaze palsy (HP:0000605)3.16255310
51Widely patent fontanelles and sutures (HP:0004492)3.15966909
52Abnormality of cells of the lymphoid lineage (HP:0012140)3.14609325
53Rickets (HP:0002748)3.11958302
54Intention tremor (HP:0002080)3.10712836
55Broad face (HP:0000283)3.10244282
56Encephalitis (HP:0002383)3.08909744
57Recurrent skin infections (HP:0001581)3.01066874
58Choreoathetosis (HP:0001266)3.00131998
59Skin rash (HP:0000988)2.99081183
60Bronchitis (HP:0012387)2.98986245
61Agitation (HP:0000713)2.98913703
62Emphysema (HP:0002097)2.94419201
63Ketoacidosis (HP:0001993)2.81349723
64Recurrent otitis media (HP:0000403)2.79731800
65Diplopia (HP:0000651)2.78913965
66Abnormality of binocular vision (HP:0011514)2.78913965
67Chronic mucocutaneous candidiasis (HP:0002728)2.77020768
68Recurrent cutaneous fungal infections (HP:0011370)2.77020768
69Hemiplegia (HP:0002301)2.71014843
70Gastrointestinal infarctions (HP:0005244)2.69285098
71Cervical subluxation (HP:0003308)2.60935744
72Ketosis (HP:0001946)2.60416276
73IgM deficiency (HP:0002850)2.59472750
74Intrahepatic cholestasis (HP:0001406)2.58115806
75Increased IgE level (HP:0003212)2.58106306
76Prolonged bleeding time (HP:0003010)2.56170394
77Viral hepatitis (HP:0006562)2.56101994
78Lymphoma (HP:0002665)2.55806942
79Urticaria (HP:0001025)2.52913977
80B lymphocytopenia (HP:0010976)2.48643887
81Pulmonary infiltrates (HP:0002113)2.47568308
82Abnormality of B cell number (HP:0010975)2.46425421
83Abnormality of aromatic amino acid family metabolism (HP:0004338)2.42421791
84Polar cataract (HP:0010696)2.41811756
85Gout (HP:0001997)2.41094134
86Difficulty running (HP:0009046)2.40881115
87Abnormality of the fovea (HP:0000493)2.40720225
88Abnormality of the peritoneum (HP:0002585)2.40592871
89Hyperglycinuria (HP:0003108)2.39443530
90Chest pain (HP:0100749)2.38463727
91Abnormality of the prostate (HP:0008775)2.37977489
92Hemorrhage of the eye (HP:0011885)2.37394650
93Pulmonary fibrosis (HP:0002206)2.36084141
94Skin ulcer (HP:0200042)2.35586492
95J-shaped sella turcica (HP:0002680)2.34095087
96Vacuolated lymphocytes (HP:0001922)2.33419812
97Skin nodule (HP:0200036)2.33272204
98Hypopigmentation of the fundus (HP:0007894)2.33205749
99Exercise-induced myalgia (HP:0003738)2.32635524
100Stomatitis (HP:0010280)2.32203484
101Testicular atrophy (HP:0000029)2.27393994
102Hematochezia (HP:0002573)2.25966913
103Hyporeflexia of lower limbs (HP:0002600)2.24825315
104Acanthosis nigricans (HP:0000956)2.22869018
105Epidermoid cyst (HP:0200040)2.22532525
106Abnormality of purine metabolism (HP:0004352)2.22019289
107Hyperlipoproteinemia (HP:0010980)2.20300665
108Spontaneous hematomas (HP:0007420)2.16759989
109Asplenia (HP:0001746)2.16512126
110Gingivitis (HP:0000230)2.15826620
111Increased IgM level (HP:0003496)2.14517369
112Abnormal hemoglobin (HP:0011902)2.13973969
113Peripheral hypomyelination (HP:0007182)2.13690729
114Abnormality of glycine metabolism (HP:0010895)2.10789607
115Abnormality of serine family amino acid metabolism (HP:0010894)2.10789607
116Pustule (HP:0200039)2.10518730
117Elevated erythrocyte sedimentation rate (HP:0003565)2.07252012
118Hemoptysis (HP:0002105)2.07152789
119Gait ataxia (HP:0002066)2.06897364
120Osteomalacia (HP:0002749)2.04987617
121Focal segmental glomerulosclerosis (HP:0000097)2.03520762
122Myositis (HP:0100614)2.03269008
123Epistaxis (HP:0000421)2.02692348
124Hepatoblastoma (HP:0002884)2.02589052
125Spastic diplegia (HP:0001264)2.01987492
126Abnormality of T cell physiology (HP:0011840)2.00535692
127Right ventricular cardiomyopathy (HP:0011663)1.99932297
128Thin bony cortex (HP:0002753)1.99220548
129Optic neuritis (HP:0100653)1.96669394
130Retrobulbar optic neuritis (HP:0100654)1.96669394
131Abnormal rod and cone electroretinograms (HP:0008323)1.96519141
132Abnormality of the pleura (HP:0002103)1.96390452
133Hyperammonemia (HP:0001987)1.96368311
134Leukopenia (HP:0001882)1.95767102
135Myokymia (HP:0002411)1.94241403
136Systemic lupus erythematosus (HP:0002725)1.94193152
137Abnormality of T cells (HP:0002843)1.92613268
138Hyperparathyroidism (HP:0000843)1.92595514
139Ulnar claw (HP:0001178)1.92470830
140Aplasia/Hypoplasia of the spleen (HP:0010451)1.92006725
141Abnormality of monocarboxylic acid metabolism (HP:0010996)1.91755236
142Hypoalphalipoproteinemia (HP:0003233)1.91618292
143Dehydration (HP:0001944)1.91353958
144Episodic fever (HP:0001954)1.90799171
145Muscle fiber splitting (HP:0003555)1.89729103
146Ureteral stenosis (HP:0000071)1.89519091
147Abnormality of incisor morphology (HP:0011063)1.87631187
148Segmental peripheral demyelination/remyelination (HP:0003481)1.87332980
149Hypertriglyceridemia (HP:0002155)1.87205026
150Dysostosis multiplex (HP:0000943)1.87151751
151Ectopia lentis (HP:0001083)1.86958826
152Increased connective tissue (HP:0009025)1.86942713
153Neurodegeneration (HP:0002180)1.85893478
154Ankle clonus (HP:0011448)1.85645874
155Orchitis (HP:0100796)1.84714449
156Wide cranial sutures (HP:0010537)1.82714083
157Pulmonary embolism (HP:0002204)1.80564195
158Sleep apnea (HP:0010535)1.80032186
159Hyperphosphatemia (HP:0002905)1.79826897
160Glomerulosclerosis (HP:0000096)1.78865666
161Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.78429876
162Degeneration of the lateral corticospinal tracts (HP:0002314)1.78429876
163Restlessness (HP:0000711)1.78334179
164Hypophosphatemia (HP:0002148)1.77055208
165Urinary glycosaminoglycan excretion (HP:0003541)1.76092753
166Mucopolysacchariduria (HP:0008155)1.76092753
167Flared iliac wings (HP:0002869)1.75741153
168Gastrointestinal dysmotility (HP:0002579)1.75384716
169Prominent nose (HP:0000448)1.75083933
170Severe visual impairment (HP:0001141)1.74137149
171Amyloidosis (HP:0011034)1.73194947
172Abnormality of mucopolysaccharide metabolism (HP:0011020)1.72775383
173Abnormality of polysaccharide metabolism (HP:0011012)1.72775383
174Abnormality of glycosaminoglycan metabolism (HP:0004371)1.72775383
175Psychosis (HP:0000709)1.72187676
176Turricephaly (HP:0000262)1.71829907
177Increased CSF protein (HP:0002922)1.71085590
178Pili torti (HP:0003777)1.70846619
179Oligomenorrhea (HP:0000876)1.69930446
180Progressive neurologic deterioration (HP:0002344)1.67885563
181Abnormality of sulfur amino acid metabolism (HP:0004339)1.67554521
182Bony spicule pigmentary retinopathy (HP:0007737)1.66861012
183Abnormality of transition element cation homeostasis (HP:0011030)1.65948481
184Hyperglycinemia (HP:0002154)1.65058797
185Abnormal cartilage morphology (HP:0002763)1.64723552
186Abnormality of the Achilles tendon (HP:0005109)1.64570001
187Tubulointerstitial fibrosis (HP:0005576)1.64304893
188Abnormality of the periventricular white matter (HP:0002518)1.63773822
189Back pain (HP:0003418)1.61781512
190Calf muscle hypertrophy (HP:0008981)1.61100706
191Abnormality of glutamine family amino acid metabolism (HP:0010902)1.56883717
192Prominent forehead (HP:0011220)1.56679663
193Abnormality of the common coagulation pathway (HP:0010990)1.56455929
194Subcapsular cataract (HP:0000523)1.56385669
195Abnormality of abdominal situs (HP:0011620)1.55309656
196Abdominal situs inversus (HP:0003363)1.55309656

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.31761433
2SIK33.77368008
3BLK3.76440981
4MST43.59951439
5ERN13.33864879
6IRAK43.17206365
7LMTK23.14510893
8NME22.92807074
9EPHB12.83438921
10GRK62.82281673
11MAP3K102.77202241
12SIK12.66586393
13PKN22.52488728
14BMPR22.43575264
15LRRK22.31302345
16TXK2.27511159
17PDGFRA2.17868256
18TRIB32.16866117
19FGFR22.15081399
20FER2.13478969
21BTK2.09390149
22TYK22.01095350
23FGFR41.98138945
24SYK1.95735735
25PRPF4B1.91689423
26TAOK31.87208353
27MAP3K111.84184532
28STK391.82976106
29MAPK121.80970309
30WNK41.78902714
31PRKD31.78601196
32MARK31.62485897
33MAP3K21.56262119
34LYN1.54873054
35PTK61.54310193
36MARK21.51559270
37PKN11.48235534
38EPHA21.47428768
39KIT1.42989202
40TNK21.40251337
41TTN1.39070565
42RET1.36773329
43MAP2K31.36499894
44NTRK31.35755759
45TYRO31.29813479
46PTK2B1.29668404
47PRKD21.26389725
48NTRK11.25782096
49ZAP701.25705507
50PAK31.24522898
51RIPK41.21963575
52PTK21.20553437
53MAP2K41.20516811
54MYLK1.16089345
55MAPK111.15722739
56IKBKE1.14700239
57TAOK11.13170515
58INSR1.11891536
59CDK191.09669583
60KSR21.09137451
61LCK1.08729325
62SCYL21.08100749
63TESK11.07721185
64IKBKB1.07548835
65PRKCH1.07423846
66STK101.06870386
67PAK61.06766835
68TBK11.06460945
69BCKDK1.05971449
70CSF1R1.05012575
71MAPK130.99016890
72FRK0.98598047
73FGFR30.98332504
74TAOK20.96629308
75ITK0.96623839
76JAK30.96545161
77CDC42BPA0.92005449
78MAP3K70.89991920
79LATS20.88969083
80HCK0.88458639
81PASK0.87073877
82DMPK0.86286355
83EPHB20.85753407
84ICK0.83801078
85MAP3K60.83618320
86FGR0.82811882
87TESK20.82692219
88CDK50.82018098
89MAP3K30.82000252
90MAPK150.81451967
91PAK40.80963356
92PAK20.79494714
93ALK0.78825772
94EPHA40.78493482
95SIK20.77299750
96MAP3K120.76998019
97PDK30.73980160
98PDK40.73980160
99OBSCN0.72798593
100MAP2K10.72679812
101NTRK20.71358329
102DAPK20.70775878
103MINK10.69888269
104PHKG20.69484540
105PHKG10.69484540
106WNK10.69483179
107CAMK1G0.68829103
108PRKCG0.68504100
109DDR20.67772993
110JAK20.66869046
111TEC0.65927999
112GSK3A0.65212432
113ROCK20.63688213
114FGFR10.63515315
115FLT30.63345870
116STK380.62999070
117LATS10.61943507
118NLK0.61408511
119SRC0.61010959
120AKT30.60916994
121PDGFRB0.59639288
122FYN0.58401041
123PRKD10.58253348
124UHMK10.57090450
125EEF2K0.56414160
126MAPK40.56408229
127PRKCZ0.56035244
128STK110.55696456
129CDK40.54914954
130PRKACG0.54732076
131DYRK1B0.54531868
132MAP3K10.53459703
133CAMKK10.52854363
134FES0.52226346
135MET0.51474938
136MAP3K90.51392403
137MARK10.50989377
138ERBB20.50751596
139KDR0.50080713
140CSNK1E0.50068725
141CDK60.49259929
142EGFR0.47742552
143CAMK2B0.47527261
144MAP3K140.47356402
145PRKCQ0.46328144
146PIM10.44855454
147TLK10.44383887
148PDK10.43301182
149CSK0.43216451
150RIPK10.42593388
151MAP3K130.42246694
152CAMK10.41492299
153JAK10.41358785
154HIPK20.41220261
155PDPK10.40003897
156MAP3K40.39821385
157DAPK30.38764402
158MAPKAPK20.37525834
159PRKAA10.37204774
160ARAF0.36392795
161MAP2K20.34253425
162IRAK20.32890434
163ABL10.31089868
164PRKCD0.30745483
165PINK10.29296324
166ILK0.28522438
167MAPK30.27755566
168DAPK10.27267254
169MELK0.27079195
170MAP2K60.26644675
171MAP3K50.24845585
172RPS6KA60.24290037

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.23860510
2Glutathione metabolism_Homo sapiens_hsa004804.22622221
3Primary immunodeficiency_Homo sapiens_hsa053404.14171967
4B cell receptor signaling pathway_Homo sapiens_hsa046624.06039852
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.86881234
6Allograft rejection_Homo sapiens_hsa053303.82978838
7Autoimmune thyroid disease_Homo sapiens_hsa053203.78776296
8Asthma_Homo sapiens_hsa053103.76195274
9Graft-versus-host disease_Homo sapiens_hsa053323.50534210
10Tryptophan metabolism_Homo sapiens_hsa003803.48092641
11Arachidonic acid metabolism_Homo sapiens_hsa005903.39281931
12Thyroid hormone synthesis_Homo sapiens_hsa049183.35169113
13African trypanosomiasis_Homo sapiens_hsa051433.22019666
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.06883229
15Type I diabetes mellitus_Homo sapiens_hsa049402.98170582
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.86594029
17Leishmaniasis_Homo sapiens_hsa051402.85215301
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.42969212
19Viral myocarditis_Homo sapiens_hsa054162.29325894
20Antigen processing and presentation_Homo sapiens_hsa046122.21492742
21Sulfur metabolism_Homo sapiens_hsa009202.00543428
22Fatty acid degradation_Homo sapiens_hsa000711.99894132
23Osteoclast differentiation_Homo sapiens_hsa043801.96579047
24Fatty acid metabolism_Homo sapiens_hsa012121.94392273
25Arginine biosynthesis_Homo sapiens_hsa002201.94224469
26Hematopoietic cell lineage_Homo sapiens_hsa046401.88588904
27Tuberculosis_Homo sapiens_hsa051521.78886985
28PPAR signaling pathway_Homo sapiens_hsa033201.64896263
29Toxoplasmosis_Homo sapiens_hsa051451.63488174
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.63167462
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.56219690
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.54302013
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.53643301
34Herpes simplex infection_Homo sapiens_hsa051681.53329075
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44075742
36Rheumatoid arthritis_Homo sapiens_hsa053231.38970786
37T cell receptor signaling pathway_Homo sapiens_hsa046601.32778814
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.31403819
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.30385010
40Glycerolipid metabolism_Homo sapiens_hsa005611.28903986
41Salivary secretion_Homo sapiens_hsa049701.27766195
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.22432177
43Toll-like receptor signaling pathway_Homo sapiens_hsa046201.20116380
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.17591483
45Propanoate metabolism_Homo sapiens_hsa006401.17531621
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17057257
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.14904180
48Complement and coagulation cascades_Homo sapiens_hsa046101.14353210
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10056412
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.09325774
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03310432
52Morphine addiction_Homo sapiens_hsa050321.02490029
53Butanoate metabolism_Homo sapiens_hsa006501.01718619
54Chemokine signaling pathway_Homo sapiens_hsa040621.01262163
55Influenza A_Homo sapiens_hsa051641.00538966
56Bile secretion_Homo sapiens_hsa049760.99932007
57Gastric acid secretion_Homo sapiens_hsa049710.99675627
58Renin secretion_Homo sapiens_hsa049240.99381635
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98346842
60Epstein-Barr virus infection_Homo sapiens_hsa051690.97196085
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.96996836
62Lysosome_Homo sapiens_hsa041420.96640648
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96591027
64Pyruvate metabolism_Homo sapiens_hsa006200.95919754
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94371781
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93425652
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.92506947
68Glycerophospholipid metabolism_Homo sapiens_hsa005640.90868751
69beta-Alanine metabolism_Homo sapiens_hsa004100.90858788
70Fat digestion and absorption_Homo sapiens_hsa049750.89172868
71Phenylalanine metabolism_Homo sapiens_hsa003600.88618315
72HTLV-I infection_Homo sapiens_hsa051660.88382570
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.87428187
74Phagosome_Homo sapiens_hsa041450.87139665
75GABAergic synapse_Homo sapiens_hsa047270.85497810
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83077015
77Long-term potentiation_Homo sapiens_hsa047200.82897118
78Starch and sucrose metabolism_Homo sapiens_hsa005000.80694064
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.79063124
80Measles_Homo sapiens_hsa051620.78549654
81Vibrio cholerae infection_Homo sapiens_hsa051100.74806303
82Collecting duct acid secretion_Homo sapiens_hsa049660.73828378
83Estrogen signaling pathway_Homo sapiens_hsa049150.73050621
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72858975
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.72395380
86Histidine metabolism_Homo sapiens_hsa003400.70908969
87Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69898854
88Malaria_Homo sapiens_hsa051440.69332982
89Acute myeloid leukemia_Homo sapiens_hsa052210.68467943
90Prion diseases_Homo sapiens_hsa050200.66663768
91Circadian entrainment_Homo sapiens_hsa047130.66526621
92TNF signaling pathway_Homo sapiens_hsa046680.64967021
93Arginine and proline metabolism_Homo sapiens_hsa003300.64908101
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.63688850
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62789399
96Fatty acid elongation_Homo sapiens_hsa000620.62695990
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62088254
98Carbon metabolism_Homo sapiens_hsa012000.62086784
99Staphylococcus aureus infection_Homo sapiens_hsa051500.61189964
100Fatty acid biosynthesis_Homo sapiens_hsa000610.60908445
101Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59358812
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.58486732
103Synaptic vesicle cycle_Homo sapiens_hsa047210.58170679
104Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57353170
105Biosynthesis of amino acids_Homo sapiens_hsa012300.55733331
106Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55307053
107Non-small cell lung cancer_Homo sapiens_hsa052230.53993359
108Endocytosis_Homo sapiens_hsa041440.53989454
109Choline metabolism in cancer_Homo sapiens_hsa052310.53615489
110Inositol phosphate metabolism_Homo sapiens_hsa005620.53552288
111Hepatitis B_Homo sapiens_hsa051610.52483385
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52019451
113Platelet activation_Homo sapiens_hsa046110.51652829
114Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51315757
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50562218
116Amphetamine addiction_Homo sapiens_hsa050310.49799155
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.49290130
118Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48443468
119Peroxisome_Homo sapiens_hsa041460.48131164
120Viral carcinogenesis_Homo sapiens_hsa052030.47281719
121Glutamatergic synapse_Homo sapiens_hsa047240.46444702
122Calcium signaling pathway_Homo sapiens_hsa040200.46047779
123Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45760845
124Serotonergic synapse_Homo sapiens_hsa047260.44641008
125Folate biosynthesis_Homo sapiens_hsa007900.44330184
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.43973585
127Tyrosine metabolism_Homo sapiens_hsa003500.43878076
128Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.43559076
129Leukocyte transendothelial migration_Homo sapiens_hsa046700.43416053
130MAPK signaling pathway_Homo sapiens_hsa040100.42958670
131Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41182745
132Chemical carcinogenesis_Homo sapiens_hsa052040.41065152
133Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40975843
134Insulin secretion_Homo sapiens_hsa049110.40412415
135VEGF signaling pathway_Homo sapiens_hsa043700.39866329
136Shigellosis_Homo sapiens_hsa051310.38270482
137Adipocytokine signaling pathway_Homo sapiens_hsa049200.37678165
138Vitamin B6 metabolism_Homo sapiens_hsa007500.37346690
139Neurotrophin signaling pathway_Homo sapiens_hsa047220.37150022
140Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.36625340
141Cysteine and methionine metabolism_Homo sapiens_hsa002700.36597434
142FoxO signaling pathway_Homo sapiens_hsa040680.36066970
143Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35550459
144Glucagon signaling pathway_Homo sapiens_hsa049220.35070435
145Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34615328
146Pertussis_Homo sapiens_hsa051330.34607205
147Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34560720
148Phototransduction_Homo sapiens_hsa047440.34133801
149GnRH signaling pathway_Homo sapiens_hsa049120.34085019
150ABC transporters_Homo sapiens_hsa020100.33422289
151Glioma_Homo sapiens_hsa052140.32939929
152Ras signaling pathway_Homo sapiens_hsa040140.32879137
153Notch signaling pathway_Homo sapiens_hsa043300.31862520
154Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.31587142
155Oxytocin signaling pathway_Homo sapiens_hsa049210.31582475
156Dopaminergic synapse_Homo sapiens_hsa047280.31071451
157N-Glycan biosynthesis_Homo sapiens_hsa005100.30872401
158Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29770167
159Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29701832
160Rap1 signaling pathway_Homo sapiens_hsa040150.28512124
161Cholinergic synapse_Homo sapiens_hsa047250.27951938
162cAMP signaling pathway_Homo sapiens_hsa040240.27013826
163Insulin resistance_Homo sapiens_hsa049310.26886651
164Melanogenesis_Homo sapiens_hsa049160.26182483
165cGMP-PKG signaling pathway_Homo sapiens_hsa040220.25702575
166Olfactory transduction_Homo sapiens_hsa047400.24550854
167Systemic lupus erythematosus_Homo sapiens_hsa053220.24034041
168Linoleic acid metabolism_Homo sapiens_hsa005910.23955235
169Apoptosis_Homo sapiens_hsa042100.23691997
170Cocaine addiction_Homo sapiens_hsa050300.23202256
171Dorso-ventral axis formation_Homo sapiens_hsa043200.23168933
172Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22710951
173SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22568776

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