LCN9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the lipocalin family, such as LCN9, have a common structure consisting of an 8-stranded antiparallel beta-barrel that forms a cup-shaped ligand-binding pocket or calyx. Lipocalins generally bind small hydrophobic ligands and transport them to specific cells (Suzuki et al., 2004 [PubMed 15363845]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of chronic inflammatory response (GO:0002676)9.15588113
2single fertilization (GO:0007338)8.66929763
3tryptophan catabolic process (GO:0006569)8.61730290
4indole-containing compound catabolic process (GO:0042436)8.61730290
5indolalkylamine catabolic process (GO:0046218)8.61730290
6heterotypic cell-cell adhesion (GO:0034113)8.57532381
7positive regulation of type 2 immune response (GO:0002830)7.49401906
8negative regulation of interleukin-10 production (GO:0032693)7.41050029
9tryptophan metabolic process (GO:0006568)7.40716230
10aromatic amino acid family catabolic process (GO:0009074)5.90324882
11fertilization (GO:0009566)5.72117947
12amine catabolic process (GO:0009310)5.54389134
13cellular biogenic amine catabolic process (GO:0042402)5.54389134
14indolalkylamine metabolic process (GO:0006586)5.42884090
15negative regulation of interleukin-8 production (GO:0032717)5.28079762
16benzene-containing compound metabolic process (GO:0042537)4.85076306
17digestion (GO:0007586)4.65416251
18epithelial cell morphogenesis (GO:0003382)4.40170683
19negative regulation of T cell apoptotic process (GO:0070233)4.37621581
20negative regulation of endopeptidase activity (GO:0010951)4.37525268
21positive regulation of cell-cell adhesion (GO:0022409)4.34122975
22aromatic amino acid family metabolic process (GO:0009072)4.29289241
23negative regulation of peptidase activity (GO:0010466)4.17553617
24transepithelial transport (GO:0070633)3.98325659
25regulation of type 2 immune response (GO:0002828)3.89586038
26indole-containing compound metabolic process (GO:0042430)3.88084547
27regulation of clathrin-mediated endocytosis (GO:2000369)3.80321113
28reverse cholesterol transport (GO:0043691)3.69908887
29sulfur amino acid catabolic process (GO:0000098)3.63366582
30defense response to bacterium (GO:0042742)3.55061737
31N-acetylneuraminate metabolic process (GO:0006054)3.45526432
32negative regulation of protein autophosphorylation (GO:0031953)3.32528676
33negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.30449362
34phospholipid homeostasis (GO:0055091)3.22760866
35alpha-linolenic acid metabolic process (GO:0036109)3.13365770
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.11594804
37response to bacterium (GO:0009617)3.06723049
38regulation of macrophage activation (GO:0043030)3.03268276
39seminiferous tubule development (GO:0072520)25.2954293
40regulation of lipoprotein metabolic process (GO:0050746)2.99181833
41negative regulation of proteolysis (GO:0045861)2.83895291
42glial cell proliferation (GO:0014009)2.81390931
43cysteine metabolic process (GO:0006534)2.80450143
44negative regulation of protein maturation (GO:1903318)2.73786735
45negative regulation of protein processing (GO:0010955)2.73786735
46negative regulation of glycogen biosynthetic process (GO:0045719)2.73560285
47regulation of activated T cell proliferation (GO:0046006)2.72834363
48sialylation (GO:0097503)2.72481011
49regulation of beta-amyloid formation (GO:1902003)2.71838378
50complement activation, alternative pathway (GO:0006957)2.71639232
51O-glycan processing (GO:0016266)2.69117410
52negative regulation of lymphocyte apoptotic process (GO:0070229)2.67454118
53high-density lipoprotein particle remodeling (GO:0034375)2.66754672
54positive regulation of cellular amide metabolic process (GO:0034250)2.59541197
55low-density lipoprotein particle clearance (GO:0034383)2.58822127
56positive regulation of interleukin-12 production (GO:0032735)2.55732592
57columnar/cuboidal epithelial cell development (GO:0002066)2.54601021
58hormone catabolic process (GO:0042447)2.53543161
59negative regulation of hydrolase activity (GO:0051346)2.53126950
60negative regulation of glycogen metabolic process (GO:0070874)2.47325072
61negative regulation of receptor-mediated endocytosis (GO:0048261)2.47226699
62regulation of amyloid precursor protein catabolic process (GO:1902991)2.45240508
63L-serine transport (GO:0015825)2.36294012
64alpha-amino acid catabolic process (GO:1901606)2.35708473
65valine metabolic process (GO:0006573)2.35301172
66regulation of endopeptidase activity (GO:0052548)2.34290421
67lipid catabolic process (GO:0016042)2.32852281
68cellular amino acid catabolic process (GO:0009063)2.28078967
69pyrimidine ribonucleoside catabolic process (GO:0046133)2.27568341
70negative regulation of interleukin-6 production (GO:0032715)2.26546773
71response to misfolded protein (GO:0051788)2.25797155
72triglyceride catabolic process (GO:0019433)2.25401689
73regulation of peptidase activity (GO:0052547)2.22663128
74regulation of T cell apoptotic process (GO:0070232)2.22116272
75erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.21194935
76L-phenylalanine catabolic process (GO:0006559)2.21194935
77acylglycerol catabolic process (GO:0046464)2.19000884
78neutral lipid catabolic process (GO:0046461)2.19000884
79plasma lipoprotein particle remodeling (GO:0034369)2.15062393
80protein-lipid complex remodeling (GO:0034368)2.15062393
81macromolecular complex remodeling (GO:0034367)2.15062393
82COPI coating of Golgi vesicle (GO:0048205)2.12681432
83Golgi transport vesicle coating (GO:0048200)2.12681432
84positive regulation of cholesterol transport (GO:0032376)2.11651133
85positive regulation of sterol transport (GO:0032373)2.11651133
86regulation of interleukin-10 production (GO:0032653)2.09429820
87cellular response to epidermal growth factor stimulus (GO:0071364)2.08861621
88myelin maintenance (GO:0043217)2.08154488
89cellular modified amino acid catabolic process (GO:0042219)2.07046991
90glutamate metabolic process (GO:0006536)2.06735313
91negative regulation of T cell proliferation (GO:0042130)2.05438393
92serine transport (GO:0032329)2.04049022
93regulation of lipoprotein particle clearance (GO:0010984)2.02791469
94activation of protein kinase A activity (GO:0034199)2.01838984
95production of molecular mediator involved in inflammatory response (GO:0002532)14.4536916
96regulation of T cell tolerance induction (GO:0002664)14.4425541
97positive regulation of tolerance induction (GO:0002645)12.3842659
98sperm capacitation (GO:0048240)11.2277398
99regulation of tolerance induction (GO:0002643)10.7777203
100kynurenine metabolic process (GO:0070189)10.5441088

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human4.89355318
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.39356617
3IKZF1_21737484_ChIP-ChIP_HCT116_Human4.10416044
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.26630669
5AR_21572438_ChIP-Seq_LNCaP_Human3.24743191
6CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.74795463
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.68218425
8ZNF263_19887448_ChIP-Seq_K562_Human2.67673937
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.63890768
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.61924776
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.52234296
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.42360735
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.37220885
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.14850462
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.14419103
16CLOCK_20551151_ChIP-Seq_293T_Human2.07161686
17PPARA_22158963_ChIP-Seq_LIVER_Mouse1.94974497
18GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.92571348
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82256094
20GATA3_21867929_ChIP-Seq_TH1_Mouse1.81194219
21* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.77584666
22PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.74893192
23NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.73545556
24EGR1_23403033_ChIP-Seq_LIVER_Mouse1.71287618
25TET1_21451524_ChIP-Seq_MESCs_Mouse1.69621776
26SMAD1_18555785_Chip-Seq_ESCs_Mouse1.68525129
27REST_19997604_ChIP-ChIP_NEURONS_Mouse1.64660563
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.61873695
29FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.59744466
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56800963
31SMAD4_21741376_ChIP-Seq_HESCs_Human1.55215794
32FLI1_21867929_ChIP-Seq_CD8_Mouse1.53834259
33STAT1_17558387_ChIP-Seq_HELA_Human1.52776307
34RAD21_21589869_ChIP-Seq_MESCs_Mouse1.52467878
35SOX2_22085726_ChIP-Seq_NPCs_Mouse1.49838959
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.48583183
37SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43005207
38* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.42116685
39ESRRB_18555785_Chip-Seq_ESCs_Mouse1.41940901
40SMAD3_21741376_ChIP-Seq_HESCs_Human1.35910972
41TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.35172301
42ELF1_20517297_ChIP-Seq_JURKAT_Human1.33863132
43CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29003433
44* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22282018
45RACK7_27058665_Chip-Seq_MCF-7_Human1.21822963
46CTCF_18555785_Chip-Seq_ESCs_Mouse1.19323547
47MYC_27129775_Chip-Seq_CORNEA_Mouse1.18888009
48JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.17376943
49VDR_24787735_ChIP-Seq_THP-1_Human1.16933132
50SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.15619059
51PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.13036227
52SOX9_24532713_ChIP-Seq_HFSC_Mouse1.12463649
53SALL4_22934838_ChIP-ChIP_CD34+_Human1.12253209
54BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.11185625
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10991330
56MYC_19915707_ChIP-ChIP_AK7_Human1.10378418
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.08706827
58FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07840863
59SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06140576
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05282501
61FOXH1_21741376_ChIP-Seq_ESCs_Human1.03556231
62MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03388790
63REST_18959480_ChIP-ChIP_MESCs_Mouse1.02237118
64ELK4_26923725_Chip-Seq_MESODERM_Mouse1.01152852
65CBX2_27304074_Chip-Seq_ESCs_Mouse0.99441116
66SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.99339617
67* RNF2_18974828_ChIP-Seq_MESCs_Mouse0.98075078
68* EZH2_18974828_ChIP-Seq_MESCs_Mouse0.98075078
69ETS1_21867929_ChIP-Seq_TH2_Mouse0.97901124
70KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.96984684
71TP53_20018659_ChIP-ChIP_R1E_Mouse0.95771183
72SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.95477351
73ERG_21242973_ChIP-ChIP_JURKAT_Human0.95375971
74DROSHA_22980978_ChIP-Seq_HELA_Human0.95078963
75NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.94601762
76SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.94561440
77* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94049801
78ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93566073
79BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93300327
80KDM2B_26808549_Chip-Seq_REH_Human0.93261771
81KDM2B_26808549_Chip-Seq_K562_Human0.92717134
82LXR_22292898_ChIP-Seq_THP-1_Human0.92580493
83* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.91766976
84EZH2_27304074_Chip-Seq_ESCs_Mouse0.91622310
85SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.91458678
86EZH2_27294783_Chip-Seq_NPCs_Mouse0.90122367
87* P68_20966046_ChIP-Seq_HELA_Human0.89608797
88GATA1_19941826_ChIP-Seq_K562_Human0.89484176
89RAC3_21632823_ChIP-Seq_H3396_Human0.88383330
90SOX2_18555785_Chip-Seq_ESCs_Mouse0.87989412
91PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.86721501
92SOX2_20726797_ChIP-Seq_SW620_Human0.86390622
93WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.84054545
94RARA_24833708_ChIP-Seq_LIVER_Mouse0.81747452
95WT1_19549856_ChIP-ChIP_CCG9911_Human0.80885944
96PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80678679
97CSB_26484114_Chip-Seq_FIBROBLAST_Human0.80639863
98TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.80092050
99RARB_24833708_ChIP-Seq_LIVER_Mouse0.79733003
100* SMC4_20622854_ChIP-Seq_HELA_Human0.79614153

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation5.72991931
2MP0003195_calcinosis5.18795908
3MP0002254_reproductive_system_inflammat4.96786872
4MP0004043_abnormal_pH_regulation4.71638266
5MP0010234_abnormal_vibrissa_follicle4.25629752
6MP0002139_abnormal_hepatobiliary_system4.18029360
7MP0005410_abnormal_fertilization3.33386619
8MP0005058_abnormal_lysosome_morphology3.24804019
9MP0003329_amyloid_beta_deposits3.11816559
10MP0000003_abnormal_adipose_tissue2.20122803
11MP0005360_urolithiasis2.15253957
12MP0000604_amyloidosis2.11697945
13MP0010329_abnormal_lipoprotein_level2.09411110
14MP0002168_other_aberrant_phenotype1.99566441
15MP0005365_abnormal_bile_salt1.85194845
16MP0003566_abnormal_cell_adhesion1.77766259
17MP0003300_gastrointestinal_ulcer1.72010051
18MP0004885_abnormal_endolymph1.70423469
19MP0001501_abnormal_sleep_pattern1.60743255
20MP0005085_abnormal_gallbladder_physiolo1.58017615
21MP0004130_abnormal_muscle_cell1.56798578
22MP0001765_abnormal_ion_homeostasis1.53569068
23MP0005375_adipose_tissue_phenotype1.52945802
24MP0002837_dystrophic_cardiac_calcinosis1.51950938
25MP0004859_abnormal_synaptic_plasticity1.51949196
26MP0001440_abnormal_grooming_behavior1.51725583
27MP0001853_heart_inflammation1.43943892
28MP0003690_abnormal_glial_cell1.39030228
29MP0000534_abnormal_ureter_morphology1.38639792
30MP0009643_abnormal_urine_homeostasis1.36180106
31MP0003705_abnormal_hypodermis_morpholog1.34890784
32MP0004858_abnormal_nervous_system1.33819382
33MP0005332_abnormal_amino_acid1.33064692
34MP0004185_abnormal_adipocyte_glucose1.29658249
35MP0005083_abnormal_biliary_tract1.24354793
36MP0002118_abnormal_lipid_homeostasis1.20297418
37MP0001756_abnormal_urination1.19435098
38MP0002089_abnormal_postnatal_growth/wei1.17728169
39MP0000537_abnormal_urethra_morphology1.17689214
40MP0008438_abnormal_cutaneous_collagen1.17421072
41MP0005584_abnormal_enzyme/coenzyme_acti1.16390371
42MP0005275_abnormal_skin_tensile1.10346237
43MP0003191_abnormal_cellular_cholesterol1.09290774
44MP0003806_abnormal_nucleotide_metabolis1.09050984
45MP0002896_abnormal_bone_mineralization1.06065661
46MP0004270_analgesia1.04949024
47MP0002796_impaired_skin_barrier1.04294150
48MP0005636_abnormal_mineral_homeostasis0.99810078
49MP0003252_abnormal_bile_duct0.99592085
50MP0009780_abnormal_chondrocyte_physiolo0.96946917
51MP0003632_abnormal_nervous_system0.96749121
52MP0002909_abnormal_adrenal_gland0.95213156
53MP0008875_abnormal_xenobiotic_pharmacok0.95195706
54MP0005666_abnormal_adipose_tissue0.94279590
55MP0003075_altered_response_to0.93622242
56MP0000920_abnormal_myelination0.92923114
57MP0003698_abnormal_male_reproductive0.92855089
58MP0003879_abnormal_hair_cell0.87748761
59MP0000747_muscle_weakness0.87017946
60MP0002733_abnormal_thermal_nociception0.84239824
61MP0002136_abnormal_kidney_physiology0.83672504
62MP0009840_abnormal_foam_cell0.83414818
63MP0004145_abnormal_muscle_electrophysio0.83353967
64MP0000609_abnormal_liver_physiology0.79495279
65MP0002876_abnormal_thyroid_physiology0.79082600
66MP0004036_abnormal_muscle_relaxation0.78433389
67MP0002933_joint_inflammation0.78269386
68MP0003631_nervous_system_phenotype0.77096146
69MP0003635_abnormal_synaptic_transmissio0.76511399
70MP0005319_abnormal_enzyme/_coenzyme0.75061934
71MP0003633_abnormal_nervous_system0.73791652
72MP0005395_other_phenotype0.73044308
73MP0005670_abnormal_white_adipose0.68549183
74MP0002735_abnormal_chemical_nociception0.68077465
75MP0010678_abnormal_skin_adnexa0.64576278
76MP0003634_abnormal_glial_cell0.64286599
77MP0005535_abnormal_body_temperature0.62891057
78MP0000538_abnormal_urinary_bladder0.62537336
79MP0002272_abnormal_nervous_system0.62527290
80MP0005334_abnormal_fat_pad0.62178128
81MP0000462_abnormal_digestive_system0.61232104
82MP0009384_cardiac_valve_regurgitation0.60567065
83MP0005623_abnormal_meninges_morphology0.60540833
84MP0001970_abnormal_pain_threshold0.59723022
85MP0000249_abnormal_blood_vessel0.59418631
86MP0002295_abnormal_pulmonary_circulatio0.59018182
87MP0002971_abnormal_brown_adipose0.58859143
88MP0001666_abnormal_nutrient_absorption0.58669265
89MP0009053_abnormal_anal_canal0.56382718
90MP0002653_abnormal_ependyma_morphology0.55035610
91MP0000013_abnormal_adipose_tissue0.54786875
92MP0000751_myopathy0.54685565
93MP0004272_abnormal_basement_membrane0.53951755
94MP0002064_seizures0.53644195
95MP0005166_decreased_susceptibility_to0.51933074
96MP0002161_abnormal_fertility/fecundity0.51409408
97MP0004084_abnormal_cardiac_muscle0.50477799
98MP0004087_abnormal_muscle_fiber0.50180859
99MP0001177_atelectasis0.49899508
100MP0003959_abnormal_lean_body0.49069831

Predicted human phenotypes

RankGene SetZ-score
1Myocardial infarction (HP:0001658)5.39761550
2Hypophosphatemic rickets (HP:0004912)5.04916185
3Facial shape deformation (HP:0011334)4.76712085
4Potter facies (HP:0002009)4.76712085
5Vascular calcification (HP:0004934)4.72699351
6Complement deficiency (HP:0004431)4.59746364
7Cardiovascular calcification (HP:0011915)4.40527328
8Neurofibrillary tangles (HP:0002185)4.35996978
9Cerebral inclusion bodies (HP:0100314)4.22748068
10Malnutrition (HP:0004395)3.97152480
11Choroideremia (HP:0001139)3.73020806
12Neoplasm of the heart (HP:0100544)3.55810259
13Abnormality of complement system (HP:0005339)3.34368929
14Supranuclear gaze palsy (HP:0000605)3.23294672
15Xanthomatosis (HP:0000991)3.20898924
16Recurrent gram-negative bacterial infections (HP:0005420)3.20785055
17Infantile muscular hypotonia (HP:0008947)3.20012563
18Widely patent fontanelles and sutures (HP:0004492)3.17626174
19Intention tremor (HP:0002080)3.14489551
20Rickets (HP:0002748)3.11553043
21Deep venous thrombosis (HP:0002625)3.06575145
22Choreoathetosis (HP:0001266)3.04167736
23Agitation (HP:0000713)3.02652964
24Hemiplegia (HP:0002301)2.74998313
25Ketoacidosis (HP:0001993)2.68089052
26Ketosis (HP:0001946)2.48962474
27Difficulty running (HP:0009046)2.48752196
28Abnormality of the fovea (HP:0000493)2.48169353
29Polar cataract (HP:0010696)2.43913463
30Gout (HP:0001997)2.42379589
31Intrahepatic cholestasis (HP:0001406)2.42141100
32Hyperglycinuria (HP:0003108)2.38827555
33Vacuolated lymphocytes (HP:0001922)2.37938198
34Hypopigmentation of the fundus (HP:0007894)2.37635799
35Hemorrhage of the eye (HP:0011885)2.35342434
36Testicular atrophy (HP:0000029)2.31699401
37Skin nodule (HP:0200036)2.29567718
38Abnormality of aromatic amino acid family metabolism (HP:0004338)2.27831402
39Acanthosis nigricans (HP:0000956)2.24469003
40Peripheral hypomyelination (HP:0007182)2.23705517
41Hyporeflexia of lower limbs (HP:0002600)2.22997190
42Abnormality of purine metabolism (HP:0004352)2.19972818
43Hyperlipoproteinemia (HP:0010980)2.17923892
44Abnormal hemoglobin (HP:0011902)2.16782030
45Abnormality of glycine metabolism (HP:0010895)2.12343073
46Abnormality of serine family amino acid metabolism (HP:0010894)2.12343073
47Epidermoid cyst (HP:0200040)2.11169777
48Gait ataxia (HP:0002066)2.09884967
49Osteomalacia (HP:0002749)2.07509690
50Abnormal rod and cone electroretinograms (HP:0008323)2.04575271
51Focal segmental glomerulosclerosis (HP:0000097)2.04016325
52Spastic diplegia (HP:0001264)2.01245136
53Hepatoblastoma (HP:0002884)1.99965687
54Thin bony cortex (HP:0002753)1.99544236
55Muscle fiber splitting (HP:0003555)1.98392614
56Right ventricular cardiomyopathy (HP:0011663)1.96231686
57Segmental peripheral demyelination/remyelination (HP:0003481)1.95544688
58Myokymia (HP:0002411)1.95045689
59Hyperparathyroidism (HP:0000843)1.94034714
60Ulnar claw (HP:0001178)1.93548933
61Hypoalphalipoproteinemia (HP:0003233)1.89532174
62Dysostosis multiplex (HP:0000943)1.89408925
63Restlessness (HP:0000711)1.89145074
64Hypertriglyceridemia (HP:0002155)1.88863961
65Increased connective tissue (HP:0009025)1.87361952
66Hyperammonemia (HP:0001987)1.87348609
67Prominent nose (HP:0000448)1.86426790
68Systemic lupus erythematosus (HP:0002725)1.86234392
69Wide cranial sutures (HP:0010537)1.85132415
70Ectopia lentis (HP:0001083)1.83720457
71Degeneration of the lateral corticospinal tracts (HP:0002314)1.81460437
72Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.81460437
73Hyperphosphatemia (HP:0002905)1.81077318
74Abnormality of monocarboxylic acid metabolism (HP:0010996)1.78890817
75Glomerulosclerosis (HP:0000096)1.77075997
76Gastrointestinal dysmotility (HP:0002579)1.77009719
77Hyperglycinemia (HP:0002154)1.75370684
78Hypophosphatemia (HP:0002148)1.75115959
79Bony spicule pigmentary retinopathy (HP:0007737)1.73604031
80Psychosis (HP:0000709)1.72730048
81Progressive neurologic deterioration (HP:0002344)1.71957545
82Pili torti (HP:0003777)1.71558212
83Increased CSF protein (HP:0002922)1.71225996
84Turricephaly (HP:0000262)1.70316754
85Oligomenorrhea (HP:0000876)1.69567379
86Abnormal cartilage morphology (HP:0002763)1.66892372
87Abnormality of the periventricular white matter (HP:0002518)1.66524935
88Amyloidosis (HP:0011034)1.64469274
89Tubulointerstitial fibrosis (HP:0005576)1.64245744
90Abnormality of sulfur amino acid metabolism (HP:0004339)1.63571925
91Abnormality of the Achilles tendon (HP:0005109)1.63309823
92Abnormality of transition element cation homeostasis (HP:0011030)1.62474506
93Calf muscle hypertrophy (HP:0008981)1.60340875
94Back pain (HP:0003418)1.59820791
95Subcapsular cataract (HP:0000523)1.59643430
96Abnormality of abdominal situs (HP:0011620)1.58279847
97Abdominal situs inversus (HP:0003363)1.58279847
98Loss of speech (HP:0002371)1.57031729
99Abnormality of the corticospinal tract (HP:0002492)1.56973984
100Difficulty climbing stairs (HP:0003551)1.56654003

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST43.72099505
2ERN13.31263125
3LMTK23.19940352
4EPHB12.84587738
5SIK12.63489057
6PKN22.49963439
7LRRK22.34557798
8TRIB32.21878501
9PDGFRA2.19031534
10FER2.17960405
11FGFR22.16268146
12FGFR41.95106029
13TAOK31.87246407
14STK391.87211370
15PRKD31.82547447
16WNK41.81062682
17EPHA21.60592353
18MAP3K21.56591490
19PTK61.48715410
20TNK21.41375001
21TTN1.37560400
22NTRK31.36388992
23RET1.34258424
24TYRO31.31655482
25PTK2B1.28347396
26PAK31.27379574
27NTRK11.27239081
28RIPK41.23793842
29MAP2K41.18819606
30PTK21.18578418
31SCYL21.13910475
32MYLK1.12846420
33INSR1.12260223
34CDK191.11471175
35KSR21.11437839
36PAK61.11201377
37TESK11.10960674
38STK101.08868763
39PRKCH1.05876865
40BCKDK1.05176912
41FRK0.95866347
42FGFR30.95861372
43LATS20.92884460
44PDK30.87035187
45PDK40.87035187
46ALK0.86822712
47MAP3K70.86245756
48DMPK0.85116256
49PAK40.85104354
50EPHB20.83538817
51CDK50.82763342
52PAK20.82370696
53ICK0.82327108
54MAP3K60.78624547
55EPHA40.78496706
56MAP3K120.78327646
57SIK20.74841766
58MAP2K10.73911666
59PRKCG0.72390877
60NTRK20.69840815
61WNK10.69337799
62MINK10.68750332
63PHKG20.67972574
64PHKG10.67972574
65CAMK1G0.66839451
66DDR20.66741364
67AKT30.66694626
68GSK3A0.66458152
69STK380.64921319
70DAPK20.64483315
71JAK20.64147911
72FGFR10.63358770
73ROCK20.62698024
74LATS10.60829257
75SRC0.59650403
76PDGFRB0.58426723
77FLT30.58261569
78MAP3K90.58237304
79PRKD10.57991007
80EEF2K0.57887614
81FYN0.57535541
82UHMK10.56125730
83PRKCZ0.55989691
84PRKACG0.54931698
85CSNK1E0.54190616
86MARK10.53147920
87CDK60.51892142
88MET0.51253967
89FES0.50956337
90ERBB20.49861003
91EGFR0.46678944
92PDK10.44455315
93PRKCQ0.42331666
94PDPK10.42094354
95CSK0.40939061
96MAP3K130.40398900
97GRK50.38274953
98RIPK10.37719162
99DAPK30.36740465
100JAK10.36361286

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.28075942
2Glutathione metabolism_Homo sapiens_hsa004804.33747341
3Arachidonic acid metabolism_Homo sapiens_hsa005903.50136644
4Tryptophan metabolism_Homo sapiens_hsa003803.47839684
5Thyroid hormone synthesis_Homo sapiens_hsa049183.39799481
6African trypanosomiasis_Homo sapiens_hsa051433.28819875
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.06465013
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.79073894
9Sulfur metabolism_Homo sapiens_hsa009201.99936867
10Fatty acid degradation_Homo sapiens_hsa000711.98113957
11Fatty acid metabolism_Homo sapiens_hsa012121.95120397
12Arginine biosynthesis_Homo sapiens_hsa002201.90333732
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.64815689
14PPAR signaling pathway_Homo sapiens_hsa033201.63530943
15Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.53108519
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.52952021
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41033891
18Glycerolipid metabolism_Homo sapiens_hsa005611.31973889
19Salivary secretion_Homo sapiens_hsa049701.29679413
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.19640800
21Propanoate metabolism_Homo sapiens_hsa006401.16645478
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16597448
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.11348928
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.09690282
25Complement and coagulation cascades_Homo sapiens_hsa046101.09360634
26Butanoate metabolism_Homo sapiens_hsa006501.00957282
27Lysosome_Homo sapiens_hsa041421.00894519
28Gastric acid secretion_Homo sapiens_hsa049711.00676329
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99635522
30Renin secretion_Homo sapiens_hsa049240.99545005
31Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98844329
32Bile secretion_Homo sapiens_hsa049760.96988293
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95667962
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95315354
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95063795
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94586827
37Pyruvate metabolism_Homo sapiens_hsa006200.92731230
38beta-Alanine metabolism_Homo sapiens_hsa004100.90438823
39Fat digestion and absorption_Homo sapiens_hsa049750.89198922
40GABAergic synapse_Homo sapiens_hsa047270.86750456
41Long-term potentiation_Homo sapiens_hsa047200.84647655
42Phenylalanine metabolism_Homo sapiens_hsa003600.83291729
43Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83140520
44Starch and sucrose metabolism_Homo sapiens_hsa005000.78262752
45Collecting duct acid secretion_Homo sapiens_hsa049660.76879773
46Vibrio cholerae infection_Homo sapiens_hsa051100.76318544
47Estrogen signaling pathway_Homo sapiens_hsa049150.75721286
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75288694
49Prion diseases_Homo sapiens_hsa050200.68125855
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67389160
51Circadian entrainment_Homo sapiens_hsa047130.67129034
52Arginine and proline metabolism_Homo sapiens_hsa003300.65345879
53Carbon metabolism_Homo sapiens_hsa012000.63435382
54Histidine metabolism_Homo sapiens_hsa003400.62763755
55Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62538943
56Fatty acid elongation_Homo sapiens_hsa000620.62073139
57Fatty acid biosynthesis_Homo sapiens_hsa000610.60537010
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.59326435
59Synaptic vesicle cycle_Homo sapiens_hsa047210.58601171
60Staphylococcus aureus infection_Homo sapiens_hsa051500.57806236
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57642470
62Biosynthesis of amino acids_Homo sapiens_hsa012300.56416883
63Vitamin B6 metabolism_Homo sapiens_hsa007500.54866628
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54657580
65Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52240737
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51486069
67Folate biosynthesis_Homo sapiens_hsa007900.50253650
68Amphetamine addiction_Homo sapiens_hsa050310.50097145
69Glutamatergic synapse_Homo sapiens_hsa047240.46147273
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45103727
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.44983163
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.44436636
73Peroxisome_Homo sapiens_hsa041460.43444440
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42416561
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41500017
76Insulin secretion_Homo sapiens_hsa049110.40582032
77Tyrosine metabolism_Homo sapiens_hsa003500.37992622
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.37763187
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37699561
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37280306
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.37035660
82Chemical carcinogenesis_Homo sapiens_hsa052040.35377593
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34819186
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34542559
85GnRH signaling pathway_Homo sapiens_hsa049120.34476760
86Glucagon signaling pathway_Homo sapiens_hsa049220.34355486
87Glioma_Homo sapiens_hsa052140.33450182
88N-Glycan biosynthesis_Homo sapiens_hsa005100.33152079
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33106513
90Dopaminergic synapse_Homo sapiens_hsa047280.32135962
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.31124556
92ABC transporters_Homo sapiens_hsa020100.31114470
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30340053
94Cholinergic synapse_Homo sapiens_hsa047250.27373844
95cAMP signaling pathway_Homo sapiens_hsa040240.26218843
96Melanogenesis_Homo sapiens_hsa049160.26105781
97Insulin resistance_Homo sapiens_hsa049310.26034968
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.25807578
99Olfactory transduction_Homo sapiens_hsa047400.23815741
100Oxytocin signaling pathway_Homo sapiens_hsa049210.22974111

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