LCNL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuronal ion channel clustering (GO:0045161)7.22013056
2glomerular basement membrane development (GO:0032836)6.70205529
3synaptic vesicle docking involved in exocytosis (GO:0016081)6.46986084
4positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr5.35549851
5synaptic vesicle maturation (GO:0016188)5.31610286
6peripheral nervous system axon ensheathment (GO:0032292)5.14401740
7myelination in peripheral nervous system (GO:0022011)5.14401740
8glutamate secretion (GO:0014047)5.12691306
9mesenchymal-epithelial cell signaling (GO:0060638)5.06894986
10otic vesicle formation (GO:0030916)5.00997448
11skeletal muscle adaptation (GO:0043501)4.87591403
12synaptic vesicle exocytosis (GO:0016079)4.80940282
13cellular potassium ion homeostasis (GO:0030007)4.80027361
14regulation of synaptic vesicle exocytosis (GO:2000300)4.70837125
15sodium ion export (GO:0071436)4.68995966
16axon ensheathment in central nervous system (GO:0032291)4.63887804
17central nervous system myelination (GO:0022010)4.63887804
18lung epithelium development (GO:0060428)4.62918601
19regulation of short-term neuronal synaptic plasticity (GO:0048172)4.52688224
20regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 4.51592061
21lateral sprouting from an epithelium (GO:0060601)4.41618412
22peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.36972425
23amino acid import (GO:0043090)4.34014304
24L-amino acid import (GO:0043092)4.26860109
25negative regulation of Rho protein signal transduction (GO:0035024)4.21338295
26negative regulation of stress fiber assembly (GO:0051497)4.20006903
27regulation of synaptic vesicle transport (GO:1902803)4.17246638
28regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.97905951
29membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.95390825
30negative regulation of actin filament bundle assembly (GO:0032232)3.91732271
31camera-type eye morphogenesis (GO:0048593)3.87423281
32positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.82066843
33organ growth (GO:0035265)3.81667954
34locomotory exploration behavior (GO:0035641)3.80899715
35cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.80174875
36radial glial cell differentiation (GO:0060019)3.75377443
37regulation of neuronal synaptic plasticity (GO:0048168)3.72151894
38potassium ion homeostasis (GO:0055075)3.71862085
39neurotransmitter secretion (GO:0007269)3.64916007
40vocalization behavior (GO:0071625)3.54635964
41ionotropic glutamate receptor signaling pathway (GO:0035235)3.52411305
42potassium ion import (GO:0010107)3.46807432
43striated muscle hypertrophy (GO:0014897)3.42408308
44postsynaptic membrane organization (GO:0001941)3.38581548
45limb bud formation (GO:0060174)3.37989974
46cell communication by electrical coupling (GO:0010644)3.37089348
47cerebellar granule cell differentiation (GO:0021707)3.35196098
48positive regulation of synapse maturation (GO:0090129)3.34018507
49regulation of mitochondrial depolarization (GO:0051900)3.32069252
50synaptic vesicle endocytosis (GO:0048488)3.25249357
51regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.21608505
52exploration behavior (GO:0035640)3.19458948
53cellular sodium ion homeostasis (GO:0006883)3.19334611
54regulation of long-term neuronal synaptic plasticity (GO:0048169)3.18520372
55regulation of ARF protein signal transduction (GO:0032012)3.15967184
56embryonic camera-type eye development (GO:0031076)3.15738235
57negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.13742616
58branch elongation of an epithelium (GO:0060602)3.10436930
59regulation of synapse structural plasticity (GO:0051823)3.07427694
60positive regulation of Rap GTPase activity (GO:0032854)3.06872300
61positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)3.05179551
62protein localization to cell surface (GO:0034394)3.03981687
63positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.03953948
64neuromuscular process controlling balance (GO:0050885)3.02249585
65neurotransmitter transport (GO:0006836)2.99493163
66muscle hypertrophy (GO:0014896)2.97713751
67activation of protein kinase A activity (GO:0034199)2.97670623
68regulation of glutamate receptor signaling pathway (GO:1900449)2.91890122
69myelination (GO:0042552)2.90242722
70positive regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045737)2.90172308
71regulation of voltage-gated calcium channel activity (GO:1901385)2.89455484
72muscle cell fate commitment (GO:0042693)2.88711168
73ensheathment of neurons (GO:0007272)2.87886576
74axon ensheathment (GO:0008366)2.87886576
75synaptic transmission, glutamatergic (GO:0035249)2.86575214
76regulation of synaptic plasticity (GO:0048167)2.85921299
77neuronal action potential propagation (GO:0019227)2.85137553
78regulation of circadian sleep/wake cycle, sleep (GO:0045187)2.84972352
79regulation of circadian sleep/wake cycle (GO:0042749)2.84972352
80neurotransmitter uptake (GO:0001504)2.83285751
81negative regulation of synaptic transmission, GABAergic (GO:0032229)2.82025730
82positive regulation of dendritic spine development (GO:0060999)2.81387165
83positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.79458325
84bicarbonate transport (GO:0015701)2.79331507
85regulation of Rap GTPase activity (GO:0032317)2.78112634
86regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.77530129
87neuron cell-cell adhesion (GO:0007158)2.72526856
88regulation of neurotransmitter levels (GO:0001505)2.71975518
89regulation of neurotransmitter secretion (GO:0046928)2.71690803
90mating behavior (GO:0007617)2.68574844
91regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.67442395
92neurotransmitter-gated ion channel clustering (GO:0072578)2.66152535
93induction of positive chemotaxis (GO:0050930)2.65122461
94striated muscle adaptation (GO:0014888)2.59696078
95acidic amino acid transport (GO:0015800)2.58169874
96cytoskeletal anchoring at plasma membrane (GO:0007016)2.56530826
97cAMP-mediated signaling (GO:0019933)2.55945936
98regulation of synapse maturation (GO:0090128)2.55698577
99cerebellar Purkinje cell differentiation (GO:0021702)2.55386646
100positive regulation of adherens junction organization (GO:1903393)2.54703026

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.01136747
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.83225892
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.74851395
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.66140381
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.64512871
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.61534816
7DROSHA_22980978_ChIP-Seq_HELA_Human2.60401263
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.59636236
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.58222067
10SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.56062052
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.53171684
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.48919096
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.48052953
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.48052953
15RARB_27405468_Chip-Seq_BRAIN_Mouse2.40113553
16RNF2_27304074_Chip-Seq_ESCs_Mouse2.39296047
17SUZ12_27294783_Chip-Seq_ESCs_Mouse2.28974261
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.23986276
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.23547228
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.16555319
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.12661802
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.09954136
23ERG_21242973_ChIP-ChIP_JURKAT_Human2.09275867
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.99577230
25REST_21632747_ChIP-Seq_MESCs_Mouse1.98553287
26ZFP281_18757296_ChIP-ChIP_E14_Mouse1.90315640
27TRIM28_21343339_ChIP-Seq_HEK293_Human1.87743481
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.86625706
29KDM2B_26808549_Chip-Seq_K562_Human1.83074170
30DNAJC2_21179169_ChIP-ChIP_NT2_Human1.82165348
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.74040973
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.72847572
33LXR_22292898_ChIP-Seq_THP-1_Human1.71169858
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.69893857
35WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.65936224
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.63566331
37SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.57785409
38RING1B_27294783_Chip-Seq_ESCs_Mouse1.55442164
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.53269116
40* CTCF_27219007_Chip-Seq_Bcells_Human1.51412600
41EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.50036136
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.48731310
43ZFP281_27345836_Chip-Seq_ESCs_Mouse1.48285345
44EGR1_19032775_ChIP-ChIP_M12_Human1.39285800
45RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.39095895
46EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.36848532
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.36247126
48WT1_25993318_ChIP-Seq_PODOCYTE_Human1.33840691
49SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31942303
50OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.27291519
51ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.26747764
52PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.24765360
53RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.24688596
54CTNNB1_20460455_ChIP-Seq_HCT116_Human1.22680799
55RING1B_27294783_Chip-Seq_NPCs_Mouse1.21657402
56TET1_21490601_ChIP-Seq_MESCs_Mouse1.18194449
57KDM2B_26808549_Chip-Seq_DND41_Human1.17876983
58TP53_20018659_ChIP-ChIP_R1E_Mouse1.15879458
59EP300_21415370_ChIP-Seq_HL-1_Mouse1.11669336
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09919777
61AR_21572438_ChIP-Seq_LNCaP_Human1.08082360
62CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07172348
63KDM2B_26808549_Chip-Seq_JURKAT_Human1.04766735
64STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.03741246
65SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03720009
66SA1_27219007_Chip-Seq_ERYTHROID_Human1.02832122
67PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02461999
68UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99834548
69PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.96798044
70SMC4_20622854_ChIP-Seq_HELA_Human0.96738119
71PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.95934223
72CREB1_26743006_Chip-Seq_LNCaP_Human0.95924078
73SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95864833
74TP53_23651856_ChIP-Seq_MEFs_Mouse0.95509919
75ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.94942553
76* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94325005
77MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94130189
78DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92192936
79GBX2_23144817_ChIP-Seq_PC3_Human0.91743849
80CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91657807
81ESR1_21235772_ChIP-Seq_MCF-7_Human0.90088825
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.85939617
83OCT4_19829295_ChIP-Seq_ESCs_Human0.85566615
84TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84585664
85AR_19668381_ChIP-Seq_PC3_Human0.83298586
86YAP1_20516196_ChIP-Seq_MESCs_Mouse0.83166598
87BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82923402
88CTCF_27219007_Chip-Seq_ERYTHROID_Human0.82370472
89P68_20966046_ChIP-Seq_HELA_Human0.81102381
90ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.80808306
91TBX20_22328084_ChIP-Seq_HEART_Mouse0.80200374
92TBX20_22080862_ChIP-Seq_HEART_Mouse0.80200374
93CLOCK_20551151_ChIP-Seq_293T_Human0.80005493
94KLF4_19829295_ChIP-Seq_ESCs_Human0.78050916
95GATA1_19941827_ChIP-Seq_MEL_Mouse0.77990729
96VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.76409494
97P300_27058665_Chip-Seq_ZR-75-30cells_Human0.74834712
98KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.74499278
99NR3C1_23031785_ChIP-Seq_PC12_Mouse0.73813838
100SMC1_22415368_ChIP-Seq_MEFs_Mouse0.73697439

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot6.51135607
2MP0003878_abnormal_ear_physiology6.51135607
3MP0005257_abnormal_intraocular_pressure5.19787140
4MP0004859_abnormal_synaptic_plasticity4.99864301
5MP0004885_abnormal_endolymph4.12026458
6MP0002102_abnormal_ear_morphology3.43532621
7MP0003880_abnormal_central_pattern3.17322953
8MP0004270_analgesia2.92515652
9MP0003635_abnormal_synaptic_transmissio2.78268280
10MP0005423_abnormal_somatic_nervous2.52043318
11MP0002064_seizures2.42316328
12MP0003329_amyloid_beta_deposits2.31251923
13MP0002063_abnormal_learning/memory/cond2.27908461
14MP0004742_abnormal_vestibular_system2.25713808
15MP0003879_abnormal_hair_cell2.14526759
16MP0001486_abnormal_startle_reflex2.11676987
17MP0005248_abnormal_Harderian_gland2.06037305
18MP0009745_abnormal_behavioral_response2.04191342
19MP0001502_abnormal_circadian_rhythm2.03461085
20MP0003690_abnormal_glial_cell1.96536243
21MP0002272_abnormal_nervous_system1.94037798
22MP0005503_abnormal_tendon_morphology1.86719064
23MP0002572_abnormal_emotion/affect_behav1.85572730
24MP0001501_abnormal_sleep_pattern1.80438511
25MP0008569_lethality_at_weaning1.70038235
26MP0002132_abnormal_respiratory_system1.67481368
27MP0002734_abnormal_mechanical_nocicepti1.66008448
28MP0002909_abnormal_adrenal_gland1.62120683
29MP0001661_extended_life_span1.57569207
30MP0000579_abnormal_nail_morphology1.53712253
31MP0001968_abnormal_touch/_nociception1.53196714
32MP0000920_abnormal_myelination1.46562463
33MP0009780_abnormal_chondrocyte_physiolo1.46108273
34MP0001970_abnormal_pain_threshold1.37933203
35MP0001963_abnormal_hearing_physiology1.34956945
36MP0000778_abnormal_nervous_system1.32292480
37MP0005646_abnormal_pituitary_gland1.21339079
38MP0002735_abnormal_chemical_nociception1.18706844
39MP0000026_abnormal_inner_ear1.18426849
40MP0002295_abnormal_pulmonary_circulatio1.17767951
41MP0001756_abnormal_urination1.17382750
42MP0009046_muscle_twitch1.15330765
43MP0002736_abnormal_nociception_after1.15085572
44MP0003633_abnormal_nervous_system1.14949346
45MP0004811_abnormal_neuron_physiology1.12461168
46MP0003634_abnormal_glial_cell1.10972408
47MP0002733_abnormal_thermal_nociception1.10636162
48MP0003938_abnormal_ear_development1.10525774
49MP0004272_abnormal_basement_membrane1.08951979
50MP0000604_amyloidosis1.06944302
51MP0001905_abnormal_dopamine_level1.06614068
52MP0002882_abnormal_neuron_morphology1.01259589
53MP0002066_abnormal_motor_capabilities/c1.00546087
54MP0001440_abnormal_grooming_behavior1.00136886
55MP0002184_abnormal_innervation0.99651148
56MP0002067_abnormal_sensory_capabilities0.98240354
57MP0000955_abnormal_spinal_cord0.96313817
58MP0001485_abnormal_pinna_reflex0.96300150
59MP0003631_nervous_system_phenotype0.95530741
60MP0002557_abnormal_social/conspecific_i0.94758799
61MP0004043_abnormal_pH_regulation0.94593671
62MP0003075_altered_response_to0.87397137
63MP0000566_synostosis0.84060339
64MP0001177_atelectasis0.82231444
65MP0001984_abnormal_olfaction0.80007032
66MP0001299_abnormal_eye_distance/0.76431365
67MP0002277_abnormal_respiratory_mucosa0.76156107
68MP0003632_abnormal_nervous_system0.75142245
69MP0005167_abnormal_blood-brain_barrier0.74703037
70MP0000751_myopathy0.74450804
71MP0001958_emphysema0.68987103
72MP0002152_abnormal_brain_morphology0.68436110
73MP0010030_abnormal_orbit_morphology0.67828560
74MP0004924_abnormal_behavior0.66366207
75MP0005386_behavior/neurological_phenoty0.66366207
76MP0006072_abnormal_retinal_apoptosis0.65658669
77MP0003283_abnormal_digestive_organ0.61860889
78MP0008874_decreased_physiological_sensi0.61704804
79MP0002229_neurodegeneration0.61392198
80MP0004130_abnormal_muscle_cell0.60190931
81MP0005193_abnormal_anterior_eye0.59873616
82MP0009250_abnormal_appendicular_skeleto0.59530804
83MP0001346_abnormal_lacrimal_gland0.58091453
84MP0003137_abnormal_impulse_conducting0.55952237
85MP0002822_catalepsy0.54956857
86MP0003279_aneurysm0.54255839
87MP0005535_abnormal_body_temperature0.54008579
88MP0004085_abnormal_heartbeat0.53858560
89MP0005623_abnormal_meninges_morphology0.52729609
90MP0003183_abnormal_peptide_metabolism0.50594580
91MP0006276_abnormal_autonomic_nervous0.50531508
92MP0000747_muscle_weakness0.49645815
93MP0003119_abnormal_digestive_system0.48673617
94MP0002069_abnormal_eating/drinking_beha0.48425913
95MP0003091_abnormal_cell_migration0.46649522
96MP0003115_abnormal_respiratory_system0.46241126
97MP0005508_abnormal_skeleton_morphology0.44735400
98MP0000230_abnormal_systemic_arterial0.44172062
99MP0003705_abnormal_hypodermis_morpholog0.43887462
100MP0000762_abnormal_tongue_morphology0.43239811

Predicted human phenotypes

RankGene SetZ-score
1Aplasia involving bones of the upper limbs (HP:0009823)6.77412818
2Aplasia of the phalanges of the hand (HP:0009802)6.77412818
3Aplasia involving bones of the extremities (HP:0009825)6.77412818
4Glomerulonephritis (HP:0000099)5.93631010
5Partial duplication of thumb phalanx (HP:0009944)5.39525238
6Partial duplication of the phalanx of hand (HP:0009999)4.91698315
7Alacrima (HP:0000522)4.82353838
8Myokymia (HP:0002411)4.49261124
9Diplopia (HP:0000651)4.24772387
10Abnormality of binocular vision (HP:0011514)4.24772387
11Nephritis (HP:0000123)4.19848394
12Neurofibrillary tangles (HP:0002185)4.06022168
13Abnormality of incisor morphology (HP:0011063)3.90611757
14Decreased lacrimation (HP:0000633)3.87369473
15Focal motor seizures (HP:0011153)3.79483334
16Supranuclear gaze palsy (HP:0000605)3.67630493
17Recurrent corneal erosions (HP:0000495)3.59308840
18Obstructive sleep apnea (HP:0002870)3.58125714
19Ankle clonus (HP:0011448)3.51835692
20Conical tooth (HP:0000698)3.47573334
21Action tremor (HP:0002345)3.45056840
22Mixed hearing impairment (HP:0000410)3.42668118
23Focal seizures (HP:0007359)3.38032516
24Nonprogressive disorder (HP:0003680)3.25633421
25Cerebral inclusion bodies (HP:0100314)3.10278266
26Corneal erosion (HP:0200020)3.09730314
27Aplasia of the musculature (HP:0100854)3.08187470
28Heterochromia iridis (HP:0001100)3.04532499
29Postural instability (HP:0002172)2.99384471
30Abnormality of the salivary glands (HP:0010286)2.90112598
31Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.84480589
32Abnormality of the musculature of the hand (HP:0001421)2.78106684
33Papilledema (HP:0001085)2.67852058
34Nasolacrimal duct obstruction (HP:0000579)2.67025054
35Turricephaly (HP:0000262)2.63272439
36Polar cataract (HP:0010696)2.58867336
37Visual hallucinations (HP:0002367)2.54984284
38Febrile seizures (HP:0002373)2.50351089
39Xerostomia (HP:0000217)2.45961580
40Increased circulating renin level (HP:0000848)2.37323695
41Hypoplasia of the iris (HP:0007676)2.36463893
42Spastic gait (HP:0002064)2.36310746
43Epileptic encephalopathy (HP:0200134)2.36044245
44Abnormality of the dental root (HP:0006486)2.28989934
45Taurodontia (HP:0000679)2.28989934
46Abnormality of permanent molar morphology (HP:0011071)2.28989934
47Duplication of thumb phalanx (HP:0009942)2.27603966
48Dysmetria (HP:0001310)2.27268853
49Generalized tonic-clonic seizures (HP:0002069)2.26954505
50Abnormal eating behavior (HP:0100738)2.25031765
51Annular pancreas (HP:0001734)2.21686248
52Abnormality of the lower motor neuron (HP:0002366)2.21516101
53Corneal dystrophy (HP:0001131)2.19079681
54Abnormality of molar morphology (HP:0011070)2.17895773
55Abnormality of molar (HP:0011077)2.17895773
56Sleep apnea (HP:0010535)2.17126043
57Truncal ataxia (HP:0002078)2.16764930
58Peripheral hypomyelination (HP:0007182)2.15710025
59Intention tremor (HP:0002080)2.14271903
60Concave nail (HP:0001598)2.13960165
61Atonic seizures (HP:0010819)2.12980268
62Hemiplegia (HP:0002301)2.10117912
63Broad hallux (HP:0010055)2.09494178
64Torticollis (HP:0000473)2.08084849
65Abnormality of the dental pulp (HP:0006479)2.06396910
66Abnormality of the lacrimal duct (HP:0011481)2.05152397
67Insomnia (HP:0100785)2.02625112
68Dysdiadochokinesis (HP:0002075)2.01475694
69Depression (HP:0000716)1.99031735
70Hyperextensible skin (HP:0000974)1.96112167
71Rigidity (HP:0002063)1.94685538
72Akinesia (HP:0002304)1.94294762
73Urinary bladder sphincter dysfunction (HP:0002839)1.94189051
74Bronchomalacia (HP:0002780)1.92422889
75Protrusio acetabuli (HP:0003179)1.91500133
76Tetraplegia (HP:0002445)1.90370526
77Arterial tortuosity (HP:0005116)1.89285207
78Vascular tortuosity (HP:0004948)1.89182741
79Rapidly progressive (HP:0003678)1.88671987
80Neuronal loss in central nervous system (HP:0002529)1.88113578
81Bundle branch block (HP:0011710)1.87203586
82Bradykinesia (HP:0002067)1.86488345
83Hypoplasia of the ulna (HP:0003022)1.85137777
84Progressive cerebellar ataxia (HP:0002073)1.80016164
85Shallow orbits (HP:0000586)1.79424002
86Lower limb muscle weakness (HP:0007340)1.79060338
87Abnormality of the nasolacrimal system (HP:0000614)1.78839574
88Hyporeflexia of lower limbs (HP:0002600)1.75082873
89Anxiety (HP:0000739)1.74884037
90Clonus (HP:0002169)1.74851047
91Absent phalangeal crease (HP:0006109)1.73723759
92Megalencephaly (HP:0001355)1.72200568
93Hyperkalemia (HP:0002153)1.71974131
94Hemiparesis (HP:0001269)1.70632708
95Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.69430920
96Broad toe (HP:0001837)1.68568848
97Focal dystonia (HP:0004373)1.68437529
98Scanning speech (HP:0002168)1.68308578
99Stage 5 chronic kidney disease (HP:0003774)1.65976957
100Preaxial foot polydactyly (HP:0001841)1.62277398

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.10774118
2PAK63.54404369
3NTRK33.28865034
4NTRK13.19853595
5MARK12.84385440
6DAPK22.74192054
7UHMK12.72963571
8PRKD32.58088332
9NTRK22.55151723
10RIPK12.35060725
11CAMK2B2.33056153
12GRK52.32812828
13RIPK42.32603811
14CAMKK12.10785751
15ARAF2.03342335
16MOS1.92388782
17MAP3K91.84319473
18KSR21.54705897
19MINK11.47920948
20MAP3K131.46322326
21TYRO31.35236838
22LATS21.32623516
23CDK51.30830518
24MARK21.26862857
25TRIB31.26846585
26SGK2231.26378710
27SGK4941.26378710
28NEK61.24803693
29PHKG11.24622480
30PHKG21.24622480
31SIK21.23960149
32PRPF4B1.22532585
33FGFR21.20691632
34TNK21.18604031
35PLK21.17027549
36PINK11.14046140
37RET1.09499591
38MAPK121.09383996
39CAMK11.06473486
40ROCK21.01310161
41STK381.01261822
42SGK20.99342751
43CAMK2G0.96253381
44PRKCH0.95932518
45PDK10.93045815
46PDGFRA0.91395039
47STK110.87920056
48SGK30.84439089
49PKN10.81938880
50PRKCG0.81102083
51PDPK10.80848683
52MAPK70.78942195
53MAPK130.75548767
54BMX0.75076751
55CDK150.74614109
56MAPK100.74548735
57PAK30.74421864
58CAMK2A0.73272013
59DAPK10.72483621
60MAPKAPK50.70539621
61CDK180.69215219
62CASK0.68628241
63EPHB10.68380647
64CDK11A0.67546242
65ALK0.67276316
66MAPK40.66591461
67SGK10.65266779
68DYRK1A0.64885376
69FES0.64758230
70SIK10.64707552
71DDR20.63769928
72CDK140.61583263
73ROCK10.57480944
74CAMK2D0.55650734
75RPS6KA30.54314200
76ICK0.54271241
77PKN20.53743378
78PRKD10.52946766
79MAP3K10.48452215
80BRAF0.47351401
81PAK20.46515129
82TGFBR20.44582340
83JAK20.44391963
84JAK10.44308460
85FGFR40.44275524
86MAP2K10.44170454
87MAP3K60.43294354
88FYN0.43214173
89MAP3K110.41955064
90GRK70.40701005
91BMPR20.40030394
92CAMK40.39505757
93TESK10.39220290
94DAPK30.38029818
95MAPK80.37560551
96PRKCZ0.37406552
97MAP3K70.35849787
98AKT20.34089435
99PDGFRB0.33327298
100RAF10.31505605

Predicted pathways (KEGG)

RankGene SetZ-score
1Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.09089362
2Synaptic vesicle cycle_Homo sapiens_hsa047212.80849253
3Nicotine addiction_Homo sapiens_hsa050332.66690403
4Long-term potentiation_Homo sapiens_hsa047202.39184454
5Circadian entrainment_Homo sapiens_hsa047132.31701571
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.29843649
7Insulin secretion_Homo sapiens_hsa049112.16289259
8Amphetamine addiction_Homo sapiens_hsa050312.05478388
9Glutamatergic synapse_Homo sapiens_hsa047242.04335707
10GABAergic synapse_Homo sapiens_hsa047271.99034442
11Morphine addiction_Homo sapiens_hsa050321.93256329
12Gastric acid secretion_Homo sapiens_hsa049711.87751670
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.78425306
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.71225470
15Cocaine addiction_Homo sapiens_hsa050301.62997949
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62937525
17Nitrogen metabolism_Homo sapiens_hsa009101.60961355
18Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.59257355
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.54909216
20Dopaminergic synapse_Homo sapiens_hsa047281.51418927
21Circadian rhythm_Homo sapiens_hsa047101.49037382
22Cholinergic synapse_Homo sapiens_hsa047251.45615388
23Renin secretion_Homo sapiens_hsa049241.44263191
24Vitamin B6 metabolism_Homo sapiens_hsa007501.41472728
25Salivary secretion_Homo sapiens_hsa049701.41075516
26cAMP signaling pathway_Homo sapiens_hsa040241.34899793
27Bile secretion_Homo sapiens_hsa049761.33168034
28Oxytocin signaling pathway_Homo sapiens_hsa049211.31172334
29Calcium signaling pathway_Homo sapiens_hsa040201.27058052
30Phospholipase D signaling pathway_Homo sapiens_hsa040721.26417859
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.24459415
32Protein digestion and absorption_Homo sapiens_hsa049741.21681088
33GnRH signaling pathway_Homo sapiens_hsa049121.19669862
34ECM-receptor interaction_Homo sapiens_hsa045121.19360282
35AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.16585744
36Estrogen signaling pathway_Homo sapiens_hsa049151.12255830
37Inositol phosphate metabolism_Homo sapiens_hsa005621.10410384
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.08129495
39Rap1 signaling pathway_Homo sapiens_hsa040151.04961744
40Amoebiasis_Homo sapiens_hsa051461.04209358
41Histidine metabolism_Homo sapiens_hsa003401.04195275
42Melanogenesis_Homo sapiens_hsa049161.04064121
43Glioma_Homo sapiens_hsa052141.03056226
44Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.99443443
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.98727955
46Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.98590155
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96956194
48Pancreatic secretion_Homo sapiens_hsa049720.96276230
49Gap junction_Homo sapiens_hsa045400.93833158
50Long-term depression_Homo sapiens_hsa047300.92208926
51Ras signaling pathway_Homo sapiens_hsa040140.91173697
52Prion diseases_Homo sapiens_hsa050200.90496441
53Dilated cardiomyopathy_Homo sapiens_hsa054140.88279499
54ErbB signaling pathway_Homo sapiens_hsa040120.88121254
55Serotonergic synapse_Homo sapiens_hsa047260.87366988
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.84309696
57Axon guidance_Homo sapiens_hsa043600.83921026
58VEGF signaling pathway_Homo sapiens_hsa043700.82558836
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.80897154
60MAPK signaling pathway_Homo sapiens_hsa040100.80818694
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80121537
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78808467
63Thyroid hormone synthesis_Homo sapiens_hsa049180.78047899
64Focal adhesion_Homo sapiens_hsa045100.77077006
65Choline metabolism in cancer_Homo sapiens_hsa052310.75887950
66Cardiac muscle contraction_Homo sapiens_hsa042600.75107256
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72664629
68Taste transduction_Homo sapiens_hsa047420.72382681
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70049356
70Endocytosis_Homo sapiens_hsa041440.66558932
71Olfactory transduction_Homo sapiens_hsa047400.64885595
72Arginine and proline metabolism_Homo sapiens_hsa003300.64527742
73Melanoma_Homo sapiens_hsa052180.63854605
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63289240
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59561577
76beta-Alanine metabolism_Homo sapiens_hsa004100.58991871
77Arginine biosynthesis_Homo sapiens_hsa002200.57717214
78Renal cell carcinoma_Homo sapiens_hsa052110.57639606
79Glucagon signaling pathway_Homo sapiens_hsa049220.55043481
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53813502
81Type II diabetes mellitus_Homo sapiens_hsa049300.52588125
82Collecting duct acid secretion_Homo sapiens_hsa049660.52086185
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49625782
84Vibrio cholerae infection_Homo sapiens_hsa051100.48773077
85Wnt signaling pathway_Homo sapiens_hsa043100.47791393
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46691762
87HIF-1 signaling pathway_Homo sapiens_hsa040660.45957236
88Dorso-ventral axis formation_Homo sapiens_hsa043200.45552031
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.44505302
90mTOR signaling pathway_Homo sapiens_hsa041500.40692087
91Insulin signaling pathway_Homo sapiens_hsa049100.40609864
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.40547575
93PI3K-Akt signaling pathway_Homo sapiens_hsa041510.40258576
94Ovarian steroidogenesis_Homo sapiens_hsa049130.37582348
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.36341885
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35806007
97Small cell lung cancer_Homo sapiens_hsa052220.35801746
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34822417
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33960173
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33773081

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