LCOR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box (Fernandes et al., 2003 [PubMed 12535528]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)4.81836479
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.72660686
3pyrimidine nucleobase catabolic process (GO:0006208)4.54223958
4histone H3-K4 trimethylation (GO:0080182)4.19040201
5histone H3-K36 demethylation (GO:0070544)4.14595261
6kinetochore organization (GO:0051383)4.07403085
7behavioral response to ethanol (GO:0048149)3.98733320
8embryonic retina morphogenesis in camera-type eye (GO:0060059)3.93836226
9limb bud formation (GO:0060174)3.92355453
10DNA topological change (GO:0006265)3.86387032
11nucleobase catabolic process (GO:0046113)3.77502799
12peptidyl-lysine trimethylation (GO:0018023)3.71530736
13neurotransmitter-gated ion channel clustering (GO:0072578)3.70460234
14negative regulation of translation, ncRNA-mediated (GO:0040033)3.70151558
15regulation of translation, ncRNA-mediated (GO:0045974)3.70151558
16negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.70151558
17monoubiquitinated protein deubiquitination (GO:0035520)3.69226006
18histone H3-K4 methylation (GO:0051568)3.68979423
19negative regulation of cytosolic calcium ion concentration (GO:0051481)3.68724845
20interkinetic nuclear migration (GO:0022027)3.68111635
21presynaptic membrane assembly (GO:0097105)3.56753650
22regulation of protein glycosylation (GO:0060049)3.50070706
23kinetochore assembly (GO:0051382)3.46789970
24protein K11-linked deubiquitination (GO:0035871)3.38734472
25meiotic chromosome segregation (GO:0045132)3.38249889
26central nervous system neuron axonogenesis (GO:0021955)3.36279726
27sympathetic nervous system development (GO:0048485)3.33846072
28establishment of protein localization to Golgi (GO:0072600)3.33271839
29presynaptic membrane organization (GO:0097090)3.25569787
30cellular extravasation (GO:0045123)3.25207074
31polyketide metabolic process (GO:0030638)3.23665105
32doxorubicin metabolic process (GO:0044598)3.23665105
33daunorubicin metabolic process (GO:0044597)3.23665105
34negative regulation of dendrite development (GO:2000171)3.22257923
35DNA double-strand break processing (GO:0000729)3.21889047
36histone lysine demethylation (GO:0070076)3.21467202
37radial glial cell differentiation (GO:0060019)3.19533979
38fucose catabolic process (GO:0019317)3.14189758
39L-fucose metabolic process (GO:0042354)3.14189758
40L-fucose catabolic process (GO:0042355)3.14189758
41neutrophil mediated immunity (GO:0002446)3.13907743
42resolution of meiotic recombination intermediates (GO:0000712)3.12242237
43CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.11822630
44T-helper cell differentiation (GO:0042093)3.11822630
45epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.11638087
46glial cell proliferation (GO:0014009)3.10936339
47central nervous system projection neuron axonogenesis (GO:0021952)3.10907050
48histone H3-K9 methylation (GO:0051567)3.10707499
49negative regulation of DNA-dependent DNA replication (GO:2000104)3.10396773
50regulation of germinal center formation (GO:0002634)3.09505347
51nuclear pore complex assembly (GO:0051292)3.09234853
52cytoplasmic mRNA processing body assembly (GO:0033962)3.08349450
53ether lipid metabolic process (GO:0046485)3.05882886
54regulation of DNA endoreduplication (GO:0032875)3.03052686
55histone demethylation (GO:0016577)3.02947846
56endocrine pancreas development (GO:0031018)3.02913497
57regulation of pigment cell differentiation (GO:0050932)3.02587432
58regulation of collateral sprouting (GO:0048670)3.00643098
59regulation of establishment of cell polarity (GO:2000114)3.00298895
60retrograde transport, vesicle recycling within Golgi (GO:0000301)2.97187273
61histone H3-K9 modification (GO:0061647)2.96449523
62olfactory bulb development (GO:0021772)2.95980225
63DNA strand renaturation (GO:0000733)2.95935255
64establishment of nucleus localization (GO:0040023)2.93655126
65kidney morphogenesis (GO:0060993)2.92610989
66inner cell mass cell proliferation (GO:0001833)2.91183173
67mitotic chromosome condensation (GO:0007076)2.90254072
68histone deubiquitination (GO:0016578)2.88136571
69sister chromatid cohesion (GO:0007062)2.87924090
70positive regulation of developmental pigmentation (GO:0048087)2.87596634
71regulation of telomere maintenance (GO:0032204)2.85486477
72replicative senescence (GO:0090399)2.84914431
73CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.82924455
74DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.82020816
75positive regulation of cell cycle checkpoint (GO:1901978)2.81906661
76histamine secretion (GO:0001821)2.81902949
77intraciliary transport (GO:0042073)2.80888629
78embryonic epithelial tube formation (GO:0001838)2.77656168
79replication fork processing (GO:0031297)2.77635424
80poly(A)+ mRNA export from nucleus (GO:0016973)2.77442730
81negative regulation of neurotransmitter transport (GO:0051589)2.76584479
82N-terminal protein amino acid acetylation (GO:0006474)2.76401801
83nerve growth factor signaling pathway (GO:0038180)2.76114292
84cornea development in camera-type eye (GO:0061303)2.75969724
85hepatocyte differentiation (GO:0070365)2.75841655
86negative regulation of keratinocyte proliferation (GO:0010839)2.75251503
87keratinocyte development (GO:0003334)2.73832925
88response to pheromone (GO:0019236)2.73798629
89definitive hemopoiesis (GO:0060216)2.72126315
90regulation of meiosis I (GO:0060631)2.71297537
91histone mRNA catabolic process (GO:0071044)2.70716426
92histone lysine methylation (GO:0034968)2.69846089
93axonal fasciculation (GO:0007413)2.68288002
94gamma-aminobutyric acid transport (GO:0015812)2.67192751
95attachment of spindle microtubules to kinetochore (GO:0008608)2.66774454
96dentate gyrus development (GO:0021542)2.66677459
97epithelial cilium movement (GO:0003351)2.65436972
98prenylation (GO:0097354)2.63967198
99protein prenylation (GO:0018342)2.63967198
100microtubule anchoring (GO:0034453)2.62777240
101DNA alkylation (GO:0006305)2.60953620
102DNA methylation (GO:0006306)2.60953620
103retinal ganglion cell axon guidance (GO:0031290)2.59728131
104B cell homeostasis (GO:0001782)2.59506143
105proline transport (GO:0015824)2.59181660
106regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.58984328
107positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.58984328
108phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.58647377
109nucleus localization (GO:0051647)2.58218169
110Golgi to endosome transport (GO:0006895)2.57633908
111regulation of gene expression by genetic imprinting (GO:0006349)2.57079473
112regulation of keratinocyte proliferation (GO:0010837)2.56872018
113neuron recognition (GO:0008038)2.56839538
114pore complex assembly (GO:0046931)2.56705112
115RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.55956580
116positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.55628030
117regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.55628030
118retinal cone cell development (GO:0046549)2.55580291
119male sex determination (GO:0030238)2.54410693
120regulation of mitotic spindle checkpoint (GO:1903504)2.53753011
121regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.53753011
122epithelial tube formation (GO:0072175)2.53526952
123embryonic camera-type eye morphogenesis (GO:0048596)2.53211151
124protein targeting to Golgi (GO:0000042)2.53035036
125somite development (GO:0061053)2.52658767
126negative regulation of neurotransmitter secretion (GO:0046929)2.52583069
127regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.52088947
128cell morphogenesis involved in neuron differentiation (GO:0048667)2.51404274
129regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.51063586
130snRNA transcription (GO:0009301)2.50910189
131neural tube formation (GO:0001841)2.50393992
132negative regulation of B cell proliferation (GO:0030889)2.49377810
133protein dealkylation (GO:0008214)2.49269450
134protein demethylation (GO:0006482)2.49269450
135negative regulation of histone methylation (GO:0031061)2.48801481
136T cell differentiation involved in immune response (GO:0002292)2.48736013
137alpha-beta T cell differentiation involved in immune response (GO:0002293)2.48736013
138alpha-beta T cell activation involved in immune response (GO:0002287)2.48736013
139regulation of growth hormone secretion (GO:0060123)2.48639453
140centriole replication (GO:0007099)2.47933921
141vocalization behavior (GO:0071625)2.46063424
142germinal center formation (GO:0002467)2.46029163
143cilium organization (GO:0044782)2.45701328
144peptidyl-lysine methylation (GO:0018022)2.45107579
145DNA damage response, signal transduction resulting in transcription (GO:0042772)2.44702492
146negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.44450484
147myeloid leukocyte mediated immunity (GO:0002444)2.44177241
148regulation of timing of cell differentiation (GO:0048505)2.43963815
149inositol phosphate catabolic process (GO:0071545)2.42711771
150positive regulation of granulocyte differentiation (GO:0030854)2.41089040
151cilium assembly (GO:0042384)2.40376424
152regulation of sister chromatid cohesion (GO:0007063)2.39843614
153fat-soluble vitamin biosynthetic process (GO:0042362)2.39361768
154regulation of vitamin metabolic process (GO:0030656)2.39320552
155regulation of acrosome reaction (GO:0060046)2.39119248
156modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.39050117
157positive regulation by organism of defense response of other organism involved in symbiotic interact2.39050117
158modulation by symbiont of host immune response (GO:0052553)2.39050117
159positive regulation by symbiont of host defense response (GO:0052509)2.39050117
160modulation by symbiont of host defense response (GO:0052031)2.39050117
161modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.39050117
162genitalia morphogenesis (GO:0035112)2.38645842
163positive regulation of cardiac muscle cell differentiation (GO:2000727)2.37776002
164prostate gland growth (GO:0060736)2.37698821
165positive regulation of dendritic spine morphogenesis (GO:0061003)2.37499101
166behavioral response to nicotine (GO:0035095)2.37152043
167regulation of sarcomere organization (GO:0060297)2.37144940
168protein localization to cilium (GO:0061512)2.36971751
169protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.36302354
170hindbrain development (GO:0030902)2.35886155
171indolalkylamine metabolic process (GO:0006586)2.35262146
172positive regulation of growth hormone secretion (GO:0060124)2.35073770
173protein localization to Golgi apparatus (GO:0034067)2.34928792
174positive regulation of amino acid transport (GO:0051957)2.31727326
175neuronal action potential (GO:0019228)2.31704748
176protein polyglutamylation (GO:0018095)2.30346774
177transepithelial transport (GO:0070633)2.30320125
178polyol catabolic process (GO:0046174)2.28145156
179microtubule nucleation (GO:0007020)2.26315243

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.70900195
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.27698719
3CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.94205351
4ZNF274_21170338_ChIP-Seq_K562_Hela2.90716596
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.86658043
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.75103383
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.69144507
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.44517942
9TP63_19390658_ChIP-ChIP_HaCaT_Human2.41990264
10VDR_22108803_ChIP-Seq_LS180_Human2.33261124
11GATA1_22025678_ChIP-Seq_K562_Human2.29935356
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.25107436
13EWS_26573619_Chip-Seq_HEK293_Human2.13201121
14* BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.12483365
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.11683388
16TAF15_26573619_Chip-Seq_HEK293_Human2.10835783
17E2F7_22180533_ChIP-Seq_HELA_Human2.06391767
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.05227260
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.03629888
20PCGF2_27294783_Chip-Seq_ESCs_Mouse2.00943033
21* IGF1R_20145208_ChIP-Seq_DFB_Human2.00684990
22* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97793010
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.97462734
24PCGF2_27294783_Chip-Seq_NPCs_Mouse1.91632081
25SUZ12_27294783_Chip-Seq_NPCs_Mouse1.90779326
26FOXM1_23109430_ChIP-Seq_U2OS_Human1.87597534
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.85865147
28SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.80877470
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.80643106
30* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78368092
31NFE2_27457419_Chip-Seq_LIVER_Mouse1.77063289
32KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.71886672
33* ER_23166858_ChIP-Seq_MCF-7_Human1.71282198
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70402565
35UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.69271270
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.68377189
37EZH2_27294783_Chip-Seq_NPCs_Mouse1.67990923
38* FUS_26573619_Chip-Seq_HEK293_Human1.67678613
39* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67076756
40* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.67076756
41STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.66860192
42* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.63803533
43* CBP_20019798_ChIP-Seq_JUKART_Human1.63803533
44SCL_19346495_ChIP-Seq_HPC-7_Human1.62740993
45TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.62605190
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.60919367
47PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.57336268
48NANOG_18555785_Chip-Seq_ESCs_Mouse1.57137618
49* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.57023998
50GBX2_23144817_ChIP-Seq_PC3_Human1.56036517
51* AR_25329375_ChIP-Seq_VCAP_Human1.54861308
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53654635
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.51496727
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48681279
55EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.48497103
56EZH2_22144423_ChIP-Seq_EOC_Human1.47767817
57P300_19829295_ChIP-Seq_ESCs_Human1.46810716
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.45488855
59SUZ12_18555785_Chip-Seq_ESCs_Mouse1.44685251
60E2F1_18555785_Chip-Seq_ESCs_Mouse1.43736069
61NR3C1_21868756_ChIP-Seq_MCF10A_Human1.43182429
62TCF4_18268006_ChIP-ChIP_LS174T_Human1.41451414
63P53_22387025_ChIP-Seq_ESCs_Mouse1.41155415
64CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.40902615
65ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38877397
66* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.38001943
67ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37943047
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35874957
69RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.35825149
70BCAT_22108803_ChIP-Seq_LS180_Human1.35650145
71STAT3_18555785_Chip-Seq_ESCs_Mouse1.35606150
72* STAT3_23295773_ChIP-Seq_U87_Human1.35439674
73TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.33121061
74PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.31228144
75EGR1_23403033_ChIP-Seq_LIVER_Mouse1.31159573
76RUNX2_22187159_ChIP-Seq_PCA_Human1.30785329
77OCT4_18555785_Chip-Seq_ESCs_Mouse1.29975326
78RNF2_27304074_Chip-Seq_NSC_Mouse1.29544717
79FLI1_21867929_ChIP-Seq_TH2_Mouse1.29422222
80E2F4_17652178_ChIP-ChIP_JURKAT_Human1.29309508
81CMYC_18555785_Chip-Seq_ESCs_Mouse1.29178236
82STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.24990556
83AR_21572438_ChIP-Seq_LNCaP_Human1.24940164
84POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24897071
85P300_18555785_Chip-Seq_ESCs_Mouse1.24594289
86KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24409501
87NMYC_18555785_Chip-Seq_ESCs_Mouse1.23759228
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23153284
89TP53_16413492_ChIP-PET_HCT116_Human1.22887663
90TCF4_22108803_ChIP-Seq_LS180_Human1.22759227
91HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.21470011
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20968889
93CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.19250630
94SMAD4_21799915_ChIP-Seq_A2780_Human1.18395071
95ARNT_22903824_ChIP-Seq_MCF-7_Human1.18051160
96AHR_22903824_ChIP-Seq_MCF-7_Human1.17839963
97FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.17200919
98EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.17058577
99SOX2_18555785_Chip-Seq_ESCs_Mouse1.16972759
100TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.16246718
101CBX2_27304074_Chip-Seq_ESCs_Mouse1.16183688
102* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15147396
103ZFX_18555785_Chip-Seq_ESCs_Mouse1.14486256
104PRDM14_20953172_ChIP-Seq_ESCs_Human1.14463532
105TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14157311
106OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13817281
107SOX2_21211035_ChIP-Seq_LN229_Gbm1.13468881
108LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13461328
109SMAD3_21741376_ChIP-Seq_EPCs_Human1.13106302
110IRF1_19129219_ChIP-ChIP_H3396_Human1.12523341
111ESRRB_18555785_Chip-Seq_ESCs_Mouse1.12517298
112MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.11474700
113* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.11406301
114BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11207740
115RUNX1_27457419_Chip-Seq_LIVER_Mouse1.11042260
116CTCF_18555785_Chip-Seq_ESCs_Mouse1.10801695
117MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10694634
118* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10031929
119* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.09798728
120GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09180054
121* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09136036
122FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.08973992
123SMAD1_18555785_Chip-Seq_ESCs_Mouse1.08297181
124* CDX2_22108803_ChIP-Seq_LS180_Human1.08265602
125* TCF4_23295773_ChIP-Seq_U87_Human1.07110190
126GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06511120
127OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05879392
128STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05697783
129* TAL1_26923725_Chip-Seq_HPCs_Mouse1.05285083
130GATA2_21666600_ChIP-Seq_HMVEC_Human1.05240910
131* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05195724
132* KDM2B_26808549_Chip-Seq_REH_Human1.04130763
133RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03371777
134EGR1_19374776_ChIP-ChIP_THP-1_Human1.01804178
135TP53_22573176_ChIP-Seq_HFKS_Human1.01145811
136KLF4_18555785_Chip-Seq_ESCs_Mouse1.00563627
137PU1_27457419_Chip-Seq_LIVER_Mouse1.00446090
138CRX_20693478_ChIP-Seq_RETINA_Mouse1.00434616
139ELK1_19687146_ChIP-ChIP_HELA_Human0.99891314
140CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.98819016
141TBL1_22424771_ChIP-Seq_293T_Human0.97209281
142TP53_18474530_ChIP-ChIP_U2OS_Human0.96254627
143* NANOG_19829295_ChIP-Seq_ESCs_Human0.96082216

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.86871302
2MP0003787_abnormal_imprinting3.39079431
3MP0000566_synostosis3.11124895
4MP0002102_abnormal_ear_morphology2.98000778
5MP0009697_abnormal_copulation2.76601742
6MP0006292_abnormal_olfactory_placode2.68534944
7MP0003183_abnormal_peptide_metabolism2.66296889
8MP0003121_genomic_imprinting2.60387306
9MP0008877_abnormal_DNA_methylation2.58649762
10MP0003890_abnormal_embryonic-extraembry2.55869426
11MP0003880_abnormal_central_pattern2.48835026
12MP0002822_catalepsy2.34462996
13MP0002396_abnormal_hematopoietic_system2.20423124
14MP0001529_abnormal_vocalization2.20212095
15MP0002009_preneoplasia2.16474132
16MP0000778_abnormal_nervous_system2.09757962
17MP0004264_abnormal_extraembryonic_tissu2.09437398
18MP0003195_calcinosis2.06830213
19MP0002928_abnormal_bile_duct2.06227610
20MP0005084_abnormal_gallbladder_morpholo2.05569415
21MP0008058_abnormal_DNA_repair1.98377550
22MP0005187_abnormal_penis_morphology1.93126532
23MP0010094_abnormal_chromosome_stability1.89713017
24MP0003943_abnormal_hepatobiliary_system1.86716503
25MP0002166_altered_tumor_susceptibility1.83863696
26MP0004270_analgesia1.75143260
27MP0006276_abnormal_autonomic_nervous1.73400189
28MP0002006_tumorigenesis1.71436653
29MP0005408_hypopigmentation1.71217264
30MP0002751_abnormal_autonomic_nervous1.71062594
31MP0005174_abnormal_tail_pigmentation1.70170160
32MP0004808_abnormal_hematopoietic_stem1.68393104
33MP0005248_abnormal_Harderian_gland1.68254160
34MP0001984_abnormal_olfaction1.60738562
35MP0005220_abnormal_exocrine_pancreas1.59378823
36MP0004924_abnormal_behavior1.55868301
37MP0005386_behavior/neurological_phenoty1.55868301
38MP0000462_abnormal_digestive_system1.53657410
39MP0001188_hyperpigmentation1.51208551
40MP0009046_muscle_twitch1.49852887
41MP0008057_abnormal_DNA_replication1.49315480
42MP0001968_abnormal_touch/_nociception1.47887504
43MP0005379_endocrine/exocrine_gland_phen1.46751225
44MP0005365_abnormal_bile_salt1.44894606
45MP0000383_abnormal_hair_follicle1.44305211
46MP0003693_abnormal_embryo_hatching1.42583910
47MP0001346_abnormal_lacrimal_gland1.41415054
48MP0002877_abnormal_melanocyte_morpholog1.41201041
49MP0002938_white_spotting1.39124622
50MP0005076_abnormal_cell_differentiation1.37833862
51MP0001486_abnormal_startle_reflex1.35689113
52MP0000631_abnormal_neuroendocrine_gland1.34639170
53MP0009745_abnormal_behavioral_response1.31281546
54MP0003724_increased_susceptibility_to1.30988279
55MP0003252_abnormal_bile_duct1.30638674
56MP0003077_abnormal_cell_cycle1.28385699
57MP0003718_maternal_effect1.27453993
58MP0004043_abnormal_pH_regulation1.27009851
59MP0003763_abnormal_thymus_physiology1.25490751
60MP0002163_abnormal_gland_morphology1.24631497
61MP0003122_maternal_imprinting1.22862916
62MP0002234_abnormal_pharynx_morphology1.21962964
63MP0002735_abnormal_chemical_nociception1.21609129
64MP0000647_abnormal_sebaceous_gland1.20317317
65MP0008995_early_reproductive_senescence1.19710864
66MP0002876_abnormal_thyroid_physiology1.18533777
67MP0001800_abnormal_humoral_immune1.15500717
68MP0005551_abnormal_eye_electrophysiolog1.13397417
69MP0001293_anophthalmia1.11119043
70MP0002184_abnormal_innervation1.10180004
71MP0003635_abnormal_synaptic_transmissio1.09861056
72MP0002095_abnormal_skin_pigmentation1.09659859
73MP0001873_stomach_inflammation1.09533442
74MP0002272_abnormal_nervous_system1.09446677
75MP0010352_gastrointestinal_tract_polyps1.09266139
76MP0002736_abnormal_nociception_after1.08221516
77MP0005671_abnormal_response_to1.07876166
78MP0002557_abnormal_social/conspecific_i1.06783973
79MP0003119_abnormal_digestive_system1.06730470
80MP0002452_abnormal_antigen_presenting1.06435588
81MP0010678_abnormal_skin_adnexa1.05541189
82MP0002734_abnormal_mechanical_nocicepti1.02970277
83MP0000015_abnormal_ear_pigmentation1.02775875
84MP0003111_abnormal_nucleus_morphology1.02564682
85MP0005253_abnormal_eye_physiology1.02254032
86MP0003300_gastrointestinal_ulcer1.01885119
87MP0002160_abnormal_reproductive_system1.01480077
88MP0002067_abnormal_sensory_capabilities1.00420446
89MP0001835_abnormal_antigen_presentation0.99636604
90MP0003567_abnormal_fetal_cardiomyocyte0.97840338
91MP0000372_irregular_coat_pigmentation0.97416161
92MP0002063_abnormal_learning/memory/cond0.96406730
93MP0001501_abnormal_sleep_pattern0.96039569
94MP0000427_abnormal_hair_cycle0.95904625
95MP0002233_abnormal_nose_morphology0.95853113
96MP0004142_abnormal_muscle_tone0.95709853
97MP0005646_abnormal_pituitary_gland0.95379053
98MP0001944_abnormal_pancreas_morphology0.95334777
99MP0001286_abnormal_eye_development0.94853982
100MP0003868_abnormal_feces_composition0.94582819
101MP0002693_abnormal_pancreas_physiology0.93507132
102MP0006072_abnormal_retinal_apoptosis0.93133565
103MP0004811_abnormal_neuron_physiology0.92837025
104MP0001915_intracranial_hemorrhage0.92293966
105MP0002723_abnormal_immune_serum0.91997431
106MP0002277_abnormal_respiratory_mucosa0.91455807
107MP0001986_abnormal_taste_sensitivity0.91341673
108MP0009703_decreased_birth_body0.91280981
109MP0005645_abnormal_hypothalamus_physiol0.90568589
110MP0002638_abnormal_pupillary_reflex0.90480162
111MP0005464_abnormal_platelet_physiology0.90399528
112MP0010155_abnormal_intestine_physiology0.88334042
113MP0002398_abnormal_bone_marrow0.88287422
114MP0002909_abnormal_adrenal_gland0.87860899
115MP0003861_abnormal_nervous_system0.86774730
116MP0001790_abnormal_immune_system0.86607431
117MP0005387_immune_system_phenotype0.86607431
118MP0001929_abnormal_gametogenesis0.85982492
119MP0002882_abnormal_neuron_morphology0.85944458
120MP0002420_abnormal_adaptive_immunity0.85153092
121MP0005391_vision/eye_phenotype0.84880109
122MP0005395_other_phenotype0.84749992
123MP0001819_abnormal_immune_cell0.84727729
124MP0001485_abnormal_pinna_reflex0.84251922
125MP0000955_abnormal_spinal_cord0.83773653
126MP0000490_abnormal_crypts_of0.83728059
127MP0004134_abnormal_chest_morphology0.83447915
128MP0005397_hematopoietic_system_phenotyp0.83300228
129MP0001545_abnormal_hematopoietic_system0.83300228
130MP0005195_abnormal_posterior_eye0.83160685
131MP0003698_abnormal_male_reproductive0.82930409
132MP0005000_abnormal_immune_tolerance0.81221120
133MP0004215_abnormal_myocardial_fiber0.81195510
134MP0002752_abnormal_somatic_nervous0.80694609
135MP0009785_altered_susceptibility_to0.80457693
136MP0008004_abnormal_stomach_pH0.80362615
137MP0003937_abnormal_limbs/digits/tail_de0.80083697
138MP0002837_dystrophic_cardiac_calcinosis0.79754919
139MP0005310_abnormal_salivary_gland0.79590352
140MP0002572_abnormal_emotion/affect_behav0.79246268
141MP0008789_abnormal_olfactory_epithelium0.79181182
142MP0008872_abnormal_physiological_respon0.78923220
143MP0000465_gastrointestinal_hemorrhage0.78153421
144MP0003755_abnormal_palate_morphology0.77802390
145MP0003935_abnormal_craniofacial_develop0.77463131
146MP0001324_abnormal_eye_pigmentation0.77140168
147MP0005409_darkened_coat_color0.77028723
148MP0002733_abnormal_thermal_nociception0.76881696
149MP0003828_pulmonary_edema0.76849188
150MP0004085_abnormal_heartbeat0.76502593
151MP0009765_abnormal_xenobiotic_induced0.75196092
152MP0002152_abnormal_brain_morphology0.75056659
153MP0002139_abnormal_hepatobiliary_system0.74843430
154MP0001119_abnormal_female_reproductive0.74689691
155MP0002138_abnormal_hepatobiliary_system0.73776607
156MP0009764_decreased_sensitivity_to0.73616662
157MP0002419_abnormal_innate_immunity0.73423264
158MP0001851_eye_inflammation0.72262018
159MP0005367_renal/urinary_system_phenotyp0.70793155
160MP0000516_abnormal_urinary_system0.70793155
161MP0008007_abnormal_cellular_replicative0.69174362

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.19794097
2Volvulus (HP:0002580)4.17400557
3Hyperventilation (HP:0002883)4.07095517
4Abnormality of the fingertips (HP:0001211)3.73524689
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.60314313
6Drooling (HP:0002307)3.44278755
7Papillary thyroid carcinoma (HP:0002895)3.30331810
8Excessive salivation (HP:0003781)3.17927881
9Absent speech (HP:0001344)3.08443714
10Pancreatic cysts (HP:0001737)3.03893623
11Acute myeloid leukemia (HP:0004808)2.94101438
12Tubulointerstitial nephritis (HP:0001970)2.88989431
13Hypothermia (HP:0002045)2.88527441
14Renal cortical cysts (HP:0000803)2.85930881
15Ectopic kidney (HP:0000086)2.84255791
16Thyroiditis (HP:0100646)2.81215209
17Chronic hepatic failure (HP:0100626)2.78083839
18Febrile seizures (HP:0002373)2.78017741
19Optic nerve coloboma (HP:0000588)2.77646963
20Congenital sensorineural hearing impairment (HP:0008527)2.77504520
21Broad-based gait (HP:0002136)2.76709736
22Abnormality of chromosome stability (HP:0003220)2.75935318
23Widely spaced teeth (HP:0000687)2.75629436
24Gaze-evoked nystagmus (HP:0000640)2.72563713
25Pancreatic fibrosis (HP:0100732)2.71522313
26Oligodactyly (hands) (HP:0001180)2.69666231
27Abnormality of the preputium (HP:0100587)2.64394226
28Fair hair (HP:0002286)2.64369829
29Thyroid-stimulating hormone excess (HP:0002925)2.63465493
30Chronic diarrhea (HP:0002028)2.57517822
31Generalized hypopigmentation of hair (HP:0011358)2.56607152
32Capillary hemangiomas (HP:0005306)2.56554378
33Periodontitis (HP:0000704)2.53869821
34Conjugated hyperbilirubinemia (HP:0002908)2.51066291
35Abnormality of the astrocytes (HP:0100707)2.50188417
36Astrocytoma (HP:0009592)2.50188417
37Lissencephaly (HP:0001339)2.46813222
38Abnormality of midbrain morphology (HP:0002418)2.46463552
39Molar tooth sign on MRI (HP:0002419)2.46463552
40Prostate neoplasm (HP:0100787)2.43644960
41Abnormality of the renal medulla (HP:0100957)2.42298667
42Enlarged epiphyses (HP:0010580)2.37723595
43Oligodactyly (HP:0012165)2.35262663
44Hepatoblastoma (HP:0002884)2.34653454
45Nephronophthisis (HP:0000090)2.34576510
46Curly hair (HP:0002212)2.34039704
47Congenital stationary night blindness (HP:0007642)2.33388848
48Symptomatic seizures (HP:0011145)2.33088286
49Anal stenosis (HP:0002025)2.32903599
50Recurrent bacterial skin infections (HP:0005406)2.32069819
51Abnormality of the columella (HP:0009929)2.26635443
52Hip dysplasia (HP:0001385)2.24357794
53Exotropia (HP:0000577)2.23651874
54Tented upper lip vermilion (HP:0010804)2.23559665
55Protruding tongue (HP:0010808)2.23124734
56Progressive inability to walk (HP:0002505)2.22482956
57Medial flaring of the eyebrow (HP:0010747)2.21995592
58Vitreoretinal degeneration (HP:0000655)2.21281034
59Hypoplastic iliac wings (HP:0002866)2.20710051
60Pigmentary retinal degeneration (HP:0001146)2.20701467
61Delayed epiphyseal ossification (HP:0002663)2.19094161
62Hypoglycemic seizures (HP:0002173)2.18747516
63Myelodysplasia (HP:0002863)2.17308051
64Hypoplasia of the thymus (HP:0000778)2.16190009
65Glioma (HP:0009733)2.16153960
66Long eyelashes (HP:0000527)2.13494525
67Genetic anticipation (HP:0003743)2.13484085
68Midline defect of the nose (HP:0004122)2.12712037
69Lip pit (HP:0100267)2.12231168
70Facial hemangioma (HP:0000329)2.11574666
71Acanthocytosis (HP:0001927)2.10073533
72Cupped ear (HP:0000378)2.09185652
73Aplasia/Hypoplasia of the uvula (HP:0010293)2.07064043
74Flat capital femoral epiphysis (HP:0003370)2.07023065
75True hermaphroditism (HP:0010459)2.04646894
76Gingivitis (HP:0000230)2.04058115
77Widely patent fontanelles and sutures (HP:0004492)2.04003102
78Focal seizures (HP:0007359)2.03153004
79Hypoplastic labia majora (HP:0000059)2.01073274
80Inability to walk (HP:0002540)1.98827140
81Focal motor seizures (HP:0011153)1.98731582
82Abnormality of the nasal septum (HP:0000419)1.97972221
83Gingival bleeding (HP:0000225)1.96393825
84Long clavicles (HP:0000890)1.95444718
85Narrow forehead (HP:0000341)1.93452848
86Optic neuritis (HP:0100653)1.93107845
87Retrobulbar optic neuritis (HP:0100654)1.93107845
88Aplasia/Hypoplasia of the tibia (HP:0005772)1.92962314
89Neoplasm of the adrenal cortex (HP:0100641)1.92178718
90Progressive cerebellar ataxia (HP:0002073)1.92048034
91Tubulointerstitial abnormality (HP:0001969)1.91817797
92Hyperglycemia (HP:0003074)1.91779888
93Prominent nose (HP:0000448)1.91362698
94Nephroblastoma (Wilms tumor) (HP:0002667)1.90264902
95Aqueductal stenosis (HP:0002410)1.88582072
96Pachygyria (HP:0001302)1.88449712
97Abnormality of the prostate (HP:0008775)1.87115498
98Agitation (HP:0000713)1.87107737
99Pendular nystagmus (HP:0012043)1.86560121
100Type II lissencephaly (HP:0007260)1.85664418
101Genital tract atresia (HP:0001827)1.84744730
102Bony spicule pigmentary retinopathy (HP:0007737)1.83364436
103Transitional cell carcinoma of the bladder (HP:0006740)1.83104650
104Gait imbalance (HP:0002141)1.82970963
105Intestinal atresia (HP:0011100)1.82794010
106Disproportionate short-trunk short stature (HP:0003521)1.81486359
107Abnormality of incisor morphology (HP:0011063)1.81371602
108Epileptic encephalopathy (HP:0200134)1.80815436
109Abnormality of salivation (HP:0100755)1.80781747
110Abnormality of the labia minora (HP:0012880)1.80744823
111Ependymoma (HP:0002888)1.80687118
112Villous atrophy (HP:0011473)1.80672716
113Abnormality of small intestinal villus morphology (HP:0011472)1.80672716
114Truncal obesity (HP:0001956)1.79696988
115Abnormality of the hepatic vasculature (HP:0006707)1.79690510
116Small hand (HP:0200055)1.79169502
117Abnormality of the renal cortex (HP:0011035)1.79123653
118Abnormal hair whorl (HP:0010721)1.78840231
119Abnormality of eosinophils (HP:0001879)1.78671059
120Nephrogenic diabetes insipidus (HP:0009806)1.78402501
121Eosinophilia (HP:0001880)1.78276173
122Neoplasm of the oral cavity (HP:0100649)1.76234001
123Abolished electroretinogram (ERG) (HP:0000550)1.76089564
124Congenital primary aphakia (HP:0007707)1.75700785
125Abnormality of the intervertebral disk (HP:0005108)1.73772897
126Severe combined immunodeficiency (HP:0004430)1.73296751
127Dialeptic seizures (HP:0011146)1.72655063
128Absent rod-and cone-mediated responses on ERG (HP:0007688)1.72448248
129Small epiphyses (HP:0010585)1.72319508
130Abnormality of the ileum (HP:0001549)1.72213575
131Postaxial foot polydactyly (HP:0001830)1.72190695
132Abnormality of the labia majora (HP:0012881)1.72165872
133Granulocytopenia (HP:0001913)1.72058350
134Renal hypoplasia (HP:0000089)1.71868508
135Postaxial hand polydactyly (HP:0001162)1.71851612
136Cystic liver disease (HP:0006706)1.71819441
137Poikiloderma (HP:0001029)1.71336406
138Chorioretinal atrophy (HP:0000533)1.70359790
139Vaginal atresia (HP:0000148)1.69879820
140Abnormality of DNA repair (HP:0003254)1.69670253
141Urethral obstruction (HP:0000796)1.69626215
142Heterotopia (HP:0002282)1.69585873
143Atonic seizures (HP:0010819)1.69549000
144Clubbing of toes (HP:0100760)1.69426752
145Aplasia/Hypoplasia of the tongue (HP:0010295)1.69186813
146Limited elbow extension (HP:0001377)1.69115422
147Recurrent abscess formation (HP:0002722)1.68300862
148Abnormal rod and cone electroretinograms (HP:0008323)1.68263231
149Portal hypertension (HP:0001409)1.68100540
150Medulloblastoma (HP:0002885)1.67996069
151Amaurosis fugax (HP:0100576)1.67973462
152Abnormality of the parathyroid morphology (HP:0011766)1.67824925
153Dyskinesia (HP:0100660)1.67217587
154Embryonal renal neoplasm (HP:0011794)1.66763682
155Bile duct proliferation (HP:0001408)1.66669005
156Abnormal biliary tract physiology (HP:0012439)1.66669005
157Stomach cancer (HP:0012126)1.66413270
158Thyroid carcinoma (HP:0002890)1.66151996
159Hypsarrhythmia (HP:0002521)1.65092702
160Abnormal biliary tract morphology (HP:0012440)1.64754411
161Neoplasm of the tracheobronchial system (HP:0100552)1.64248083
162Leiomyosarcoma (HP:0100243)1.64243295
163Uterine leiomyosarcoma (HP:0002891)1.64243295
164Submucous cleft hard palate (HP:0000176)1.63770968
165Depressed nasal tip (HP:0000437)1.63614982
166Sloping forehead (HP:0000340)1.63248503
167Abnormality of the incisor (HP:0000676)1.63067119
168Barrel-shaped chest (HP:0001552)1.61192457
169Hypoplasia of the fovea (HP:0007750)1.60841214
170Aplasia/Hypoplasia of the fovea (HP:0008060)1.60841214
171Optic nerve hypoplasia (HP:0000609)1.60491351
172Inappropriate behavior (HP:0000719)1.59576694
173Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.59568913
174Short 1st metacarpal (HP:0010034)1.59568913

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.33318773
2INSRR3.49959640
3NUAK13.39494072
4FRK3.14417426
5TAOK33.09703515
6TRIM282.91453821
7SIK32.80549697
8EPHA32.77909945
9MARK12.76494846
10MAP3K42.58634420
11CDK122.43991990
12MAP4K22.32231462
13IRAK42.05567226
14SRPK12.00501945
15MKNK21.90276599
16CAMK1D1.81229477
17PNCK1.80692818
18BRD41.80098844
19BRSK21.71195739
20ZAK1.66531844
21ADRBK21.66157150
22BCR1.64233790
23MAP2K71.63743018
24STK31.56791772
25EPHA41.55305260
26TXK1.52538163
27TEC1.48213789
28NLK1.47414071
29YES11.41939723
30PLK41.37253342
31CCNB11.36730826
32CHUK1.35781972
33MAP3K141.34688673
34STK391.30341628
35MST41.24450875
36PAK31.18177289
37NTRK31.17757786
38LMTK21.16290933
39PINK11.14782797
40PLK21.13095322
41AKT31.12036265
42MAPK131.11365571
43ATR1.10325193
44BMPR1B1.09717006
45MKNK11.08863970
46RPS6KA41.08435352
47EIF2AK21.07523261
48CDK31.06298828
49JAK31.04201541
50CDC71.02433802
51CDK90.98563202
52MAP4K10.98352536
53RIPK10.97943232
54OXSR10.95989820
55CSNK1G20.95069513
56CDK80.94962618
57SGK20.93882975
58TNIK0.92972546
59CHEK20.91841487
60CAMK1G0.90536513
61IKBKE0.90430977
62CSNK1G30.89160368
63ERBB20.88241564
64IRAK30.86309677
65CAMKK20.85577398
66PRKCE0.85427809
67MAP3K60.85014808
68AURKB0.84125775
69SGK2230.83584441
70SGK4940.83584441
71ATM0.83397950
72PRKAA20.82405395
73PIK3CA0.80503618
74JAK10.80396792
75IRAK20.79315746
76IRAK10.78660084
77DYRK20.77596690
78ERBB30.77426586
79FER0.77144050
80MINK10.76206369
81STK38L0.75119921
82MAP2K40.74744409
83MAPK150.74010098
84PLK30.73655962
85PBK0.72877838
86DYRK30.72615734
87TTK0.71261294
88TBK10.68046253
89MELK0.67882078
90SGK30.67492133
91IKBKB0.67222842
92CDK70.66030892
93ITK0.65945787
94FGFR20.65549158
95RPS6KA50.64409301
96PDGFRB0.63896599
97ERBB40.63598824
98VRK10.63069860
99HIPK20.63013634
100MUSK0.62763292
101CSF1R0.62570474
102STK40.61845380
103ACVR1B0.61637165
104MARK30.58683476
105DYRK1A0.58101035
106PRKAA10.57480084
107PRKCG0.57252227
108SIK10.56799257
109EIF2AK30.56769369
110FLT30.56339670
111WNK40.56133956
112GRK10.56068832
113CSNK1D0.55758271
114RIPK40.54746519
115CDK60.53157339
116DMPK0.52977400
117CASK0.52449885
118BTK0.52116093
119WEE10.52016836
120KIT0.51805664
121TLK10.51591539
122KSR10.51542114
123FGFR30.50946882
124CSNK1G10.50469436
125LYN0.50312463
126CSNK1A1L0.49342197
127WNK30.49313347
128NEK20.49290862
129CLK10.49084304
130ADRBK10.47724043
131ABL10.47679000
132SGK10.45007773
133PRKCZ0.44770863
134CAMK40.44549265
135STK240.44176180
136TYK20.43770487
137PKN10.43331483
138STK110.42889429
139NTRK20.42460245
140LCK0.42380549
141TGFBR20.42328264
142TGFBR10.41604990
143PRKG20.41218614
144CDK10.40846537
145OBSCN0.40021845
146RPS6KB10.39708322
147PTK2B0.38653237
148CSNK1E0.37976795
149FGFR10.37103479
150CAMK2A0.36080041
151PRKG10.35599945
152CDK50.32660603
153WNK10.31700697
154PRKACB0.31075216

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.34742303
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.67822796
3Nicotine addiction_Homo sapiens_hsa050332.67422945
4Fanconi anemia pathway_Homo sapiens_hsa034602.65542865
5Systemic lupus erythematosus_Homo sapiens_hsa053222.28827609
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.08113280
7Butanoate metabolism_Homo sapiens_hsa006501.96888319
8Homologous recombination_Homo sapiens_hsa034401.95882560
9Taste transduction_Homo sapiens_hsa047421.92393850
10Lysine degradation_Homo sapiens_hsa003101.91113658
11Non-homologous end-joining_Homo sapiens_hsa034501.82294269
12Transcriptional misregulation in cancer_Homo sapiens_hsa052021.82233387
13Dorso-ventral axis formation_Homo sapiens_hsa043201.69891042
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.66137734
15Herpes simplex infection_Homo sapiens_hsa051681.64303649
16Propanoate metabolism_Homo sapiens_hsa006401.61891322
17Cell cycle_Homo sapiens_hsa041101.60237633
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.54920087
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.52685417
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.52225565
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.51018314
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.50564786
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.49754650
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46817730
25Dopaminergic synapse_Homo sapiens_hsa047281.46750009
26Phototransduction_Homo sapiens_hsa047441.44106930
27Basal transcription factors_Homo sapiens_hsa030221.40661621
28Glutamatergic synapse_Homo sapiens_hsa047241.39624893
29Circadian entrainment_Homo sapiens_hsa047131.39044602
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.38810823
31Measles_Homo sapiens_hsa051621.34448396
32Olfactory transduction_Homo sapiens_hsa047401.33843169
33Morphine addiction_Homo sapiens_hsa050321.32051640
34Hematopoietic cell lineage_Homo sapiens_hsa046401.31068784
35Pancreatic cancer_Homo sapiens_hsa052121.29972193
36ABC transporters_Homo sapiens_hsa020101.27092911
37Steroid biosynthesis_Homo sapiens_hsa001001.25473159
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25318065
39Regulation of autophagy_Homo sapiens_hsa041401.24900432
40MicroRNAs in cancer_Homo sapiens_hsa052061.24390746
41Small cell lung cancer_Homo sapiens_hsa052221.21923208
42Circadian rhythm_Homo sapiens_hsa047101.21516556
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21414927
44Influenza A_Homo sapiens_hsa051641.20863122
45p53 signaling pathway_Homo sapiens_hsa041151.20783402
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.20071939
47GABAergic synapse_Homo sapiens_hsa047271.19737073
48Long-term depression_Homo sapiens_hsa047301.19240324
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.18797842
50Leishmaniasis_Homo sapiens_hsa051401.16721859
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.16645737
52Primary immunodeficiency_Homo sapiens_hsa053401.14982974
53Jak-STAT signaling pathway_Homo sapiens_hsa046301.13655790
54Toll-like receptor signaling pathway_Homo sapiens_hsa046201.13631699
55Amphetamine addiction_Homo sapiens_hsa050311.13529637
56Nitrogen metabolism_Homo sapiens_hsa009101.13048215
57Sulfur metabolism_Homo sapiens_hsa009201.09804779
58Hepatitis B_Homo sapiens_hsa051611.08562857
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06287758
60Ether lipid metabolism_Homo sapiens_hsa005651.05779903
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04808603
62Serotonergic synapse_Homo sapiens_hsa047261.04609317
63Staphylococcus aureus infection_Homo sapiens_hsa051501.04581858
64Type II diabetes mellitus_Homo sapiens_hsa049301.04464377
65Cocaine addiction_Homo sapiens_hsa050301.01630096
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00601060
67TNF signaling pathway_Homo sapiens_hsa046681.00391585
68Hedgehog signaling pathway_Homo sapiens_hsa043400.98453644
69RNA degradation_Homo sapiens_hsa030180.98067486
70Viral carcinogenesis_Homo sapiens_hsa052030.97747200
71Renin secretion_Homo sapiens_hsa049240.96427096
72Linoleic acid metabolism_Homo sapiens_hsa005910.96247741
73Prostate cancer_Homo sapiens_hsa052150.95999323
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95962065
75Chronic myeloid leukemia_Homo sapiens_hsa052200.95672689
76Type I diabetes mellitus_Homo sapiens_hsa049400.95349179
77Protein export_Homo sapiens_hsa030600.94937387
78Vitamin digestion and absorption_Homo sapiens_hsa049770.93174290
79Graft-versus-host disease_Homo sapiens_hsa053320.92190187
80Hepatitis C_Homo sapiens_hsa051600.92017391
81B cell receptor signaling pathway_Homo sapiens_hsa046620.89061686
82FoxO signaling pathway_Homo sapiens_hsa040680.87328218
83Notch signaling pathway_Homo sapiens_hsa043300.86906936
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86293362
85Osteoclast differentiation_Homo sapiens_hsa043800.86094689
86Viral myocarditis_Homo sapiens_hsa054160.85589739
87Adherens junction_Homo sapiens_hsa045200.84643631
88Insulin secretion_Homo sapiens_hsa049110.83472367
89Legionellosis_Homo sapiens_hsa051340.83449643
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83200157
91Tryptophan metabolism_Homo sapiens_hsa003800.82828784
92Oocyte meiosis_Homo sapiens_hsa041140.82002921
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78707695
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77874122
95Insulin resistance_Homo sapiens_hsa049310.77372619
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.77239989
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76778086
98Prolactin signaling pathway_Homo sapiens_hsa049170.76765707
99Cholinergic synapse_Homo sapiens_hsa047250.76763148
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76520313
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75973794
102Caffeine metabolism_Homo sapiens_hsa002320.75970955
103Salivary secretion_Homo sapiens_hsa049700.72627391
104N-Glycan biosynthesis_Homo sapiens_hsa005100.71639115
105cAMP signaling pathway_Homo sapiens_hsa040240.71404423
106Retinol metabolism_Homo sapiens_hsa008300.71269888
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71088994
108Allograft rejection_Homo sapiens_hsa053300.69632712
109mRNA surveillance pathway_Homo sapiens_hsa030150.69436913
110Alcoholism_Homo sapiens_hsa050340.68542360
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68329994
112RNA transport_Homo sapiens_hsa030130.67246433
113Wnt signaling pathway_Homo sapiens_hsa043100.67123952
114Toxoplasmosis_Homo sapiens_hsa051450.64148876
115Renin-angiotensin system_Homo sapiens_hsa046140.63980055
116T cell receptor signaling pathway_Homo sapiens_hsa046600.63941543
117Axon guidance_Homo sapiens_hsa043600.63265039
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62930849
119Peroxisome_Homo sapiens_hsa041460.62560481
120mTOR signaling pathway_Homo sapiens_hsa041500.62559103
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62202125
122Sphingolipid metabolism_Homo sapiens_hsa006000.61830655
123Apoptosis_Homo sapiens_hsa042100.61172297
124Folate biosynthesis_Homo sapiens_hsa007900.60552326
125Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60166043
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59762029
127Spliceosome_Homo sapiens_hsa030400.59649708
128Endometrial cancer_Homo sapiens_hsa052130.59352453
129Epstein-Barr virus infection_Homo sapiens_hsa051690.59088885
130HTLV-I infection_Homo sapiens_hsa051660.58022615
131Starch and sucrose metabolism_Homo sapiens_hsa005000.57991786
132Inositol phosphate metabolism_Homo sapiens_hsa005620.56713109
133Colorectal cancer_Homo sapiens_hsa052100.56448872
134Chemical carcinogenesis_Homo sapiens_hsa052040.55570252
135Acute myeloid leukemia_Homo sapiens_hsa052210.55172422
136Glycerolipid metabolism_Homo sapiens_hsa005610.54452948
137Leukocyte transendothelial migration_Homo sapiens_hsa046700.52332544
138Hippo signaling pathway_Homo sapiens_hsa043900.50858215
139Chemokine signaling pathway_Homo sapiens_hsa040620.50714650
140Pertussis_Homo sapiens_hsa051330.50250418
141Calcium signaling pathway_Homo sapiens_hsa040200.50182805
142ErbB signaling pathway_Homo sapiens_hsa040120.49829340
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49812169
144Fatty acid biosynthesis_Homo sapiens_hsa000610.49688379
145Non-small cell lung cancer_Homo sapiens_hsa052230.49588295
146Pancreatic secretion_Homo sapiens_hsa049720.49472429
147TGF-beta signaling pathway_Homo sapiens_hsa043500.48751141
148Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48713838
149Malaria_Homo sapiens_hsa051440.48651747
150Gap junction_Homo sapiens_hsa045400.48463271
151Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48091476
152Ovarian steroidogenesis_Homo sapiens_hsa049130.47252595
153Tight junction_Homo sapiens_hsa045300.45991194
154Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45861928
155Autoimmune thyroid disease_Homo sapiens_hsa053200.44236738
156beta-Alanine metabolism_Homo sapiens_hsa004100.43949310
157SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43049975
158Choline metabolism in cancer_Homo sapiens_hsa052310.42918975
159Melanoma_Homo sapiens_hsa052180.42886011
160Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41989154
161Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.41727157
162Fat digestion and absorption_Homo sapiens_hsa049750.41202445
163Selenocompound metabolism_Homo sapiens_hsa004500.40354398
164cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40073933
165Pathways in cancer_Homo sapiens_hsa052000.39692147
166Platelet activation_Homo sapiens_hsa046110.38259132

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