LCORL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcription factor that appears to function in spermatogenesis. Polymorphisms in this gene are associated with measures of skeletal frame size and adult height. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)7.46383389
2axon ensheathment in central nervous system (GO:0032291)7.46383389
3myelination (GO:0042552)5.38774510
4ensheathment of neurons (GO:0007272)5.37016631
5axon ensheathment (GO:0008366)5.37016631
6negative regulation of neurotransmitter secretion (GO:0046929)5.06691391
7fatty acid elongation (GO:0030497)4.79820458
8presynaptic membrane assembly (GO:0097105)4.77192402
9limb bud formation (GO:0060174)4.47526034
10neuron cell-cell adhesion (GO:0007158)4.41561715
11activated T cell proliferation (GO:0050798)4.31771705
12presynaptic membrane organization (GO:0097090)4.31502333
13pyrimidine nucleobase catabolic process (GO:0006208)4.23809632
14photoreceptor cell differentiation (GO:0046530)4.18276623
15eye photoreceptor cell differentiation (GO:0001754)4.18276623
16asymmetric protein localization (GO:0008105)4.18143403
17neural tube formation (GO:0001841)4.16779824
18negative regulation of neurotransmitter transport (GO:0051589)4.08797839
19regulation of collateral sprouting (GO:0048670)4.03939805
20cellular response to hepatocyte growth factor stimulus (GO:0035729)4.03850999
21response to hepatocyte growth factor (GO:0035728)4.03850999
22cholesterol biosynthetic process (GO:0006695)3.99431458
23long-chain fatty acid biosynthetic process (GO:0042759)3.97976992
24oligodendrocyte differentiation (GO:0048709)3.90461437
25positive regulation of oligodendrocyte differentiation (GO:0048714)3.90191278
26L-amino acid import (GO:0043092)3.89033844
27microtubule depolymerization (GO:0007019)3.88914320
28negative regulation of axon extension (GO:0030517)3.83179252
29response to redox state (GO:0051775)3.78905327
30nucleobase catabolic process (GO:0046113)3.77284908
31glycerophospholipid catabolic process (GO:0046475)3.64054600
32dendrite morphogenesis (GO:0048813)3.58606506
33apical protein localization (GO:0045176)3.54977324
34cerebral cortex radially oriented cell migration (GO:0021799)3.52869979
35DNA double-strand break processing (GO:0000729)3.49418458
36microtubule anchoring (GO:0034453)3.46464577
37sterol biosynthetic process (GO:0016126)3.38873048
38amino acid import (GO:0043090)3.37990812
39transmission of nerve impulse (GO:0019226)3.37173378
40positive regulation of mitochondrial fission (GO:0090141)3.34163404
41positive regulation of actin filament depolymerization (GO:0030836)3.33104160
42negative regulation of axonogenesis (GO:0050771)3.32920075
43axonal fasciculation (GO:0007413)3.32880568
44Rap protein signal transduction (GO:0032486)3.31208694
45negative regulation of axon extension involved in axon guidance (GO:0048843)3.25387656
46intraciliary transport (GO:0042073)3.24669105
47nonmotile primary cilium assembly (GO:0035058)3.24238345
48regulation of pigment cell differentiation (GO:0050932)3.23926141
49peripheral nervous system axon ensheathment (GO:0032292)3.23721593
50myelination in peripheral nervous system (GO:0022011)3.23721593
51olfactory bulb development (GO:0021772)3.20109805
52response to lipoprotein particle (GO:0055094)3.19972437
53negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.18568522
54negative regulation of axon guidance (GO:1902668)3.16201475
55dendritic spine morphogenesis (GO:0060997)3.14960706
56positive regulation of neurological system process (GO:0031646)3.14233792
57neuron recognition (GO:0008038)3.13728118
58resolution of meiotic recombination intermediates (GO:0000712)3.10875666
59phosphatidylinositol 3-kinase signaling (GO:0014065)3.09280688
60magnesium ion transport (GO:0015693)3.08725660
61centriole assembly (GO:0098534)3.08214397
62neuron remodeling (GO:0016322)3.03991315
63substantia nigra development (GO:0021762)3.00809861
64myelin maintenance (GO:0043217)2.99556237
65prenylation (GO:0097354)2.98956659
66protein prenylation (GO:0018342)2.98956659
67response to epinephrine (GO:0071871)2.96857781
68cranial nerve development (GO:0021545)2.95866290
69replication fork processing (GO:0031297)2.95525101
70astrocyte development (GO:0014002)2.95085945
71nerve growth factor signaling pathway (GO:0038180)2.94093879
72negative regulation of JUN kinase activity (GO:0043508)2.93605185
73cilium assembly (GO:0042384)2.93359511
74protein K6-linked ubiquitination (GO:0085020)2.93348907
75cilium organization (GO:0044782)2.92155021
76cellular response to epinephrine stimulus (GO:0071872)2.89295435
77peptidyl-tyrosine autophosphorylation (GO:0038083)2.88359679
78spinal cord motor neuron differentiation (GO:0021522)2.86373486
79epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.85977984
80cilium morphogenesis (GO:0060271)2.84806666
81motile cilium assembly (GO:0044458)2.84196465
82chromatin remodeling at centromere (GO:0031055)2.83783231
83response to methylmercury (GO:0051597)2.83591701
84response to pheromone (GO:0019236)2.83093574
85Golgi to plasma membrane protein transport (GO:0043001)2.81985785
86establishment of mitochondrion localization (GO:0051654)2.80853155
87phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.79695243
88isoprenoid biosynthetic process (GO:0008299)2.79089443
89limb development (GO:0060173)2.78453210
90appendage development (GO:0048736)2.78453210
91protein polyglutamylation (GO:0018095)2.78419633
92regulation of oligodendrocyte differentiation (GO:0048713)2.78412665
93calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.77627539
94regulation of centriole replication (GO:0046599)2.77006632
95kinetochore organization (GO:0051383)2.76892467
96microtubule polymerization or depolymerization (GO:0031109)2.76008631
97spermatid nucleus differentiation (GO:0007289)2.74073671
98neuronal ion channel clustering (GO:0045161)2.73835167
99behavioral response to nicotine (GO:0035095)2.73742133
100protein palmitoylation (GO:0018345)2.72188865
101CENP-A containing nucleosome assembly (GO:0034080)2.71416735
102retina layer formation (GO:0010842)2.70473109
103histone H3-K9 methylation (GO:0051567)2.70179583
104retinal rod cell development (GO:0046548)2.69107859
105nucleotide transmembrane transport (GO:1901679)2.66381887
106ER overload response (GO:0006983)2.66358853
107import into cell (GO:0098657)2.66189894
108regulation of DNA endoreduplication (GO:0032875)2.66173556
109regulation of development, heterochronic (GO:0040034)2.66085305
110developmental pigmentation (GO:0048066)2.65661585
111negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.64129241
112negative regulation of translation, ncRNA-mediated (GO:0040033)2.64129241
113regulation of translation, ncRNA-mediated (GO:0045974)2.64129241
114regulation of sarcomere organization (GO:0060297)2.64019144
115inositol phosphate catabolic process (GO:0071545)2.63946618
116regulation of timing of cell differentiation (GO:0048505)2.63744419
117regulation of axon guidance (GO:1902667)2.63191679
118interkinetic nuclear migration (GO:0022027)2.62931466
119maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.62058293
120regulation of axon extension involved in axon guidance (GO:0048841)2.61635415
121synapse assembly (GO:0007416)2.60635979
122epithelial cilium movement (GO:0003351)2.59488488
123protein localization to cilium (GO:0061512)2.59307055
124regulation of telomere maintenance (GO:0032204)2.58619566
125histone H3-K4 trimethylation (GO:0080182)2.58125770
126pancreas development (GO:0031016)2.58116362
127semaphorin-plexin signaling pathway (GO:0071526)2.58001089
128central nervous system projection neuron axonogenesis (GO:0021952)2.57613557
129positive regulation of mRNA processing (GO:0050685)2.57051979
130cyclic nucleotide catabolic process (GO:0009214)2.56622393
131kinetochore assembly (GO:0051382)2.54726367
132histone H2B ubiquitination (GO:0033523)2.53707579
133establishment of protein localization to Golgi (GO:0072600)2.53336361
134retinal ganglion cell axon guidance (GO:0031290)2.51602034
135locomotory exploration behavior (GO:0035641)2.51535015
136membrane protein ectodomain proteolysis (GO:0006509)2.49079654
137centriole replication (GO:0007099)2.47293898
138Sertoli cell development (GO:0060009)2.45597312
139proline transport (GO:0015824)2.45495935
140regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.45249044
141neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.43942300
142negative regulation of DNA-dependent DNA replication (GO:2000104)2.43605708
143sympathetic nervous system development (GO:0048485)2.43572292
144neural nucleus development (GO:0048857)2.41756893
145peripheral nervous system development (GO:0007422)2.41673139
146regulation of mitotic spindle checkpoint (GO:1903504)2.41398327
147regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.41398327
148postsynaptic membrane organization (GO:0001941)2.39664380
149positive regulation of action potential (GO:0045760)2.39579231
150DNA integration (GO:0015074)2.39182298
151GPI anchor metabolic process (GO:0006505)2.38815923
152photoreceptor cell maintenance (GO:0045494)2.38553499
153response to monoamine (GO:0071867)2.38497559
154response to catecholamine (GO:0071869)2.38497559
155central nervous system neuron axonogenesis (GO:0021955)2.38329082
156gamma-aminobutyric acid transport (GO:0015812)2.38218708
157somite development (GO:0061053)2.38150880
158startle response (GO:0001964)2.38054023
159membrane assembly (GO:0071709)2.37972205
160retinal cone cell development (GO:0046549)2.37171809
161recombinational repair (GO:0000725)2.36856912
162hindbrain development (GO:0030902)2.36782743
163photoreceptor cell development (GO:0042461)2.36342318
164cellular component assembly involved in morphogenesis (GO:0010927)2.35016705
165double-strand break repair via homologous recombination (GO:0000724)2.33627296
166mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.33078780
167positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.33078780
168histone exchange (GO:0043486)2.32313513
169microtubule organizing center organization (GO:0031023)2.31930147
170organelle disassembly (GO:1903008)2.30804523
171histone H2A acetylation (GO:0043968)2.30779780
172negative regulation of cytosolic calcium ion concentration (GO:0051481)2.30667606
173attachment of spindle microtubules to kinetochore (GO:0008608)2.30146378
174spindle checkpoint (GO:0031577)2.30109509
175eye photoreceptor cell development (GO:0042462)2.29383006
176negative regulation of transcription regulatory region DNA binding (GO:2000678)2.27076828
177head development (GO:0060322)2.25880331
178regulation of cilium movement (GO:0003352)2.25710598
179protein targeting to Golgi (GO:0000042)2.25686175
180postreplication repair (GO:0006301)2.25126826
181inositol phosphate dephosphorylation (GO:0046855)2.24218827
182phosphorylated carbohydrate dephosphorylation (GO:0046838)2.24218827
183protein K11-linked deubiquitination (GO:0035871)2.23607055
184negative regulation of oligodendrocyte differentiation (GO:0048715)2.23593252
185mitotic spindle checkpoint (GO:0071174)2.22510599
186negative regulation of DNA recombination (GO:0045910)2.21798104
187DNA replication-independent nucleosome assembly (GO:0006336)2.21585018
188DNA replication-independent nucleosome organization (GO:0034724)2.21585018
189mitotic sister chromatid cohesion (GO:0007064)2.21065646

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.53770484
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.46073494
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.15850080
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.04356932
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.83128730
6SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.58044119
7EZH2_22144423_ChIP-Seq_EOC_Human2.43901327
8OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.30803460
9FUS_26573619_Chip-Seq_HEK293_Human2.28070765
10TAF15_26573619_Chip-Seq_HEK293_Human2.25101754
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.22278965
12WT1_19549856_ChIP-ChIP_CCG9911_Human2.00294529
13CDX2_19796622_ChIP-Seq_MESCs_Mouse1.92805894
14PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.92516909
15ER_23166858_ChIP-Seq_MCF-7_Human1.92119571
16* P300_19829295_ChIP-Seq_ESCs_Human1.91246040
17AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.87241202
18SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.87130638
19IGF1R_20145208_ChIP-Seq_DFB_Human1.86726524
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86604334
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.84774247
22E2F4_17652178_ChIP-ChIP_JURKAT_Human1.83581457
23* SMAD3_21741376_ChIP-Seq_EPCs_Human1.83366059
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82630352
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.81872902
26EWS_26573619_Chip-Seq_HEK293_Human1.80297998
27AR_21572438_ChIP-Seq_LNCaP_Human1.76413579
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76380250
29TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.70876123
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67105210
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.66663997
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.65410142
33NANOG_18555785_Chip-Seq_ESCs_Mouse1.64232709
34STAT3_23295773_ChIP-Seq_U87_Human1.63123890
35ELK1_19687146_ChIP-ChIP_HELA_Human1.60594698
36HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.56999462
37MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56550305
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.55952220
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.54651047
40SMAD4_21799915_ChIP-Seq_A2780_Human1.54435030
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.54315271
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54051827
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53154580
44EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.52732732
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51724684
46CBP_20019798_ChIP-Seq_JUKART_Human1.51724684
47BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.51683944
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.51312461
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50813317
50CMYC_18555785_Chip-Seq_ESCs_Mouse1.49614144
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49466234
52SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.47905114
53RBPJ_22232070_ChIP-Seq_NCS_Mouse1.46489990
54* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46365330
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.44620119
56SUZ12_18555785_Chip-Seq_ESCs_Mouse1.44364454
57POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44208253
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44208253
59SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.43237185
60E2F1_18555785_Chip-Seq_ESCs_Mouse1.42402236
61* TCF4_23295773_ChIP-Seq_U87_Human1.40050098
62EZH2_27304074_Chip-Seq_ESCs_Mouse1.40021893
63P53_22387025_ChIP-Seq_ESCs_Mouse1.39812125
64FOXM1_23109430_ChIP-Seq_U2OS_Human1.39799955
65JARID2_20064375_ChIP-Seq_MESCs_Mouse1.39091183
66* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.38989880
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38713140
68TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38260634
69P300_18555785_Chip-Seq_ESCs_Mouse1.37906709
70TP53_16413492_ChIP-PET_HCT116_Human1.37828203
71AR_25329375_ChIP-Seq_VCAP_Human1.37731035
72FLI1_27457419_Chip-Seq_LIVER_Mouse1.37706261
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35723561
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33720608
75SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.33373796
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33350174
77ZNF274_21170338_ChIP-Seq_K562_Hela1.33240791
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28651082
79* BCAT_22108803_ChIP-Seq_LS180_Human1.27858561
80POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27088402
81E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.26986885
82RNF2_27304074_Chip-Seq_NSC_Mouse1.26623379
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.24753620
84* RUNX2_22187159_ChIP-Seq_PCA_Human1.24727255
85AHR_22903824_ChIP-Seq_MCF-7_Human1.24448352
86KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.23372706
87NFE2_27457419_Chip-Seq_LIVER_Mouse1.23107778
88STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.21924305
89KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21852456
90STAT3_18555785_Chip-Seq_ESCs_Mouse1.21683930
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21397875
92EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.20936539
93ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19743674
94NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.18430691
95NRF2_20460467_ChIP-Seq_MEFs_Mouse1.18430691
96TAL1_26923725_Chip-Seq_HPCs_Mouse1.18354200
97PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17538186
98* SOX2_21211035_ChIP-Seq_LN229_Gbm1.16571702
99SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.16379798
100VDR_22108803_ChIP-Seq_LS180_Human1.16189977
101SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16165284
102OCT4_18555785_Chip-Seq_ESCs_Mouse1.16010562
103LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15999327
104CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15272861
105EED_16625203_ChIP-ChIP_MESCs_Mouse1.15236084
106IRF1_19129219_ChIP-ChIP_H3396_Human1.15162880
107PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15109567
108* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15076767
109FLI1_21867929_ChIP-Seq_TH2_Mouse1.14475665
110RNF2_27304074_Chip-Seq_ESCs_Mouse1.14280991
111DROSHA_22980978_ChIP-Seq_HELA_Human1.13735601
112RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.13665662
113BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13574967
114RUNX1_27457419_Chip-Seq_LIVER_Mouse1.13209885
115TP63_19390658_ChIP-ChIP_HaCaT_Human1.12924172
116NMYC_18555785_Chip-Seq_ESCs_Mouse1.12903885
117MTF2_20144788_ChIP-Seq_MESCs_Mouse1.12653296
118TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12360621
119* TCF4_22108803_ChIP-Seq_LS180_Human1.11921276
120SOX2_18555785_Chip-Seq_ESCs_Mouse1.09624386
121SOX9_26525672_Chip-Seq_HEART_Mouse1.08372994
122YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07155123
123* MYC_18940864_ChIP-ChIP_HL60_Human1.05816603
124* JUN_21703547_ChIP-Seq_K562_Human1.04631376
125FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03787779
126RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03679809
127KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02896451
128GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00981461
129EST1_17652178_ChIP-ChIP_JURKAT_Human0.99354853
130CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.99213728
131TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98205273
132CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95548725
133TP53_22573176_ChIP-Seq_HFKS_Human0.95493571

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.01981479
2MP0005171_absent_coat_pigmentation3.94680557
3MP0000569_abnormal_digit_pigmentation3.28918373
4MP0000778_abnormal_nervous_system3.02152875
5MP0004742_abnormal_vestibular_system2.92293272
6MP0005409_darkened_coat_color2.87386691
7MP0004885_abnormal_endolymph2.43661550
8MP0000462_abnormal_digestive_system2.43379142
9MP0003136_yellow_coat_color2.39971158
10MP0004270_analgesia2.39700132
11MP0004134_abnormal_chest_morphology2.35269625
12MP0003787_abnormal_imprinting2.20686520
13MP0003690_abnormal_glial_cell2.19962735
14MP0003880_abnormal_central_pattern2.16292613
15MP0010678_abnormal_skin_adnexa2.11920978
16MP0001486_abnormal_startle_reflex2.10687300
17MP0001485_abnormal_pinna_reflex2.06707671
18MP0003634_abnormal_glial_cell1.98140754
19MP0003950_abnormal_plasma_membrane1.97861483
20MP0000383_abnormal_hair_follicle1.97490381
21MP0001299_abnormal_eye_distance/1.84254358
22MP0001529_abnormal_vocalization1.82292211
23MP0001188_hyperpigmentation1.75270902
24MP0002009_preneoplasia1.72932755
25MP0005551_abnormal_eye_electrophysiolog1.71596023
26MP0002938_white_spotting1.70779176
27MP0010094_abnormal_chromosome_stability1.70298951
28MP0002822_catalepsy1.68731017
29MP0002234_abnormal_pharynx_morphology1.66536373
30MP0002837_dystrophic_cardiac_calcinosis1.64041658
31MP0005408_hypopigmentation1.60515934
32MP0003632_abnormal_nervous_system1.59533992
33MP0005174_abnormal_tail_pigmentation1.58373570
34MP0000015_abnormal_ear_pigmentation1.57866000
35MP0000631_abnormal_neuroendocrine_gland1.56958369
36MP0008789_abnormal_olfactory_epithelium1.56325952
37MP0008058_abnormal_DNA_repair1.55568463
38MP0006072_abnormal_retinal_apoptosis1.55455825
39MP0001986_abnormal_taste_sensitivity1.54929528
40MP0005499_abnormal_olfactory_system1.52628471
41MP0005394_taste/olfaction_phenotype1.52628471
42MP0005423_abnormal_somatic_nervous1.51887024
43MP0005253_abnormal_eye_physiology1.51105218
44MP0004133_heterotaxia1.48249831
45MP0009780_abnormal_chondrocyte_physiolo1.47681545
46MP0005645_abnormal_hypothalamus_physiol1.47543561
47MP0002272_abnormal_nervous_system1.47116126
48MP0006292_abnormal_olfactory_placode1.44693369
49MP0003937_abnormal_limbs/digits/tail_de1.44292987
50MP0005195_abnormal_posterior_eye1.43154639
51MP0008057_abnormal_DNA_replication1.39912752
52MP0004381_abnormal_hair_follicle1.38539234
53MP0005248_abnormal_Harderian_gland1.38375007
54MP0002229_neurodegeneration1.37087802
55MP0002734_abnormal_mechanical_nocicepti1.34894199
56MP0002882_abnormal_neuron_morphology1.33061972
57MP0001905_abnormal_dopamine_level1.30173258
58MP0005379_endocrine/exocrine_gland_phen1.29183233
59MP0000372_irregular_coat_pigmentation1.28992376
60MP0005187_abnormal_penis_morphology1.28905621
61MP0001661_extended_life_span1.24452539
62MP0003121_genomic_imprinting1.24144603
63MP0003183_abnormal_peptide_metabolism1.23974144
64MP0002064_seizures1.23251842
65MP0003195_calcinosis1.23023173
66MP0001502_abnormal_circadian_rhythm1.22385740
67MP0003122_maternal_imprinting1.21630292
68MP0000955_abnormal_spinal_cord1.20164738
69MP0005410_abnormal_fertilization1.20105823
70MP0002736_abnormal_nociception_after1.17399702
71MP0001963_abnormal_hearing_physiology1.17066729
72MP0002233_abnormal_nose_morphology1.16921141
73MP0001293_anophthalmia1.15647722
74MP0002752_abnormal_somatic_nervous1.14329955
75MP0000049_abnormal_middle_ear1.13889718
76MP0001968_abnormal_touch/_nociception1.13537026
77MP0002557_abnormal_social/conspecific_i1.12534072
78MP0002184_abnormal_innervation1.10190565
79MP0008877_abnormal_DNA_methylation1.08099731
80MP0003718_maternal_effect1.07592922
81MP0003567_abnormal_fetal_cardiomyocyte1.07132741
82MP0004142_abnormal_muscle_tone1.06909869
83MP0002751_abnormal_autonomic_nervous1.05548590
84MP0002572_abnormal_emotion/affect_behav1.05163984
85MP0001177_atelectasis1.05072538
86MP0006276_abnormal_autonomic_nervous1.03401172
87MP0000537_abnormal_urethra_morphology1.03061365
88MP0002067_abnormal_sensory_capabilities1.02226995
89MP0005391_vision/eye_phenotype1.02144403
90MP0002909_abnormal_adrenal_gland1.01990282
91MP0009745_abnormal_behavioral_response1.01182984
92MP0004215_abnormal_myocardial_fiber1.00831874
93MP0003172_abnormal_lysosome_physiology1.00303803
94MP0002152_abnormal_brain_morphology1.00125220
95MP0009697_abnormal_copulation1.00055208
96MP0000427_abnormal_hair_cycle0.99309380
97MP0003635_abnormal_synaptic_transmissio0.99165001
98MP0001984_abnormal_olfaction0.98232261
99MP0001286_abnormal_eye_development0.97714718
100MP0000647_abnormal_sebaceous_gland0.97112623
101MP0000566_synostosis0.96606277
102MP0001346_abnormal_lacrimal_gland0.95715112
103MP0010386_abnormal_urinary_bladder0.94827632
104MP0002177_abnormal_outer_ear0.94661174
105MP0004859_abnormal_synaptic_plasticity0.94543950
106MP0003938_abnormal_ear_development0.94402325
107MP0002928_abnormal_bile_duct0.93778737
108MP0004811_abnormal_neuron_physiology0.93506103
109MP0003119_abnormal_digestive_system0.93240103
110MP0004924_abnormal_behavior0.92160408
111MP0005386_behavior/neurological_phenoty0.92160408
112MP0003861_abnormal_nervous_system0.91498406
113MP0003890_abnormal_embryonic-extraembry0.89961956
114MP0009046_muscle_twitch0.89817278
115MP0003755_abnormal_palate_morphology0.89385316
116MP0003631_nervous_system_phenotype0.89374278
117MP0002697_abnormal_eye_size0.89320259
118MP0002063_abnormal_learning/memory/cond0.88772773
119MP0003935_abnormal_craniofacial_develop0.88119899
120MP0001929_abnormal_gametogenesis0.86558033
121MP0001324_abnormal_eye_pigmentation0.86330805
122MP0003698_abnormal_male_reproductive0.86183653
123MP0002210_abnormal_sex_determination0.85893217
124MP0006035_abnormal_mitochondrial_morpho0.85623573
125MP0000026_abnormal_inner_ear0.84605142
126MP0008995_early_reproductive_senescence0.84364509
127MP0002095_abnormal_skin_pigmentation0.83110359
128MP0005646_abnormal_pituitary_gland0.82411376
129MP0003111_abnormal_nucleus_morphology0.81615696
130MP0004147_increased_porphyrin_level0.80627648
131MP0001440_abnormal_grooming_behavior0.79999931
132MP0002066_abnormal_motor_capabilities/c0.79776543
133MP0002102_abnormal_ear_morphology0.78924811
134MP0002638_abnormal_pupillary_reflex0.78462042
135MP0003385_abnormal_body_wall0.77584290

Predicted human phenotypes

RankGene SetZ-score
1Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.33225606
2Degeneration of the lateral corticospinal tracts (HP:0002314)5.33225606
3Abnormality of the corticospinal tract (HP:0002492)4.13580783
4Sensory axonal neuropathy (HP:0003390)4.07476452
5Neurofibrillary tangles (HP:0002185)3.73901623
6Abnormal auditory evoked potentials (HP:0006958)3.55058883
7Alacrima (HP:0000522)3.45935994
8Abnormality of the parathyroid morphology (HP:0011766)3.33029216
9White forelock (HP:0002211)3.21347644
10Cupped ear (HP:0000378)3.12864686
11Molar tooth sign on MRI (HP:0002419)3.09505853
12Abnormality of midbrain morphology (HP:0002418)3.09505853
13Decreased lacrimation (HP:0000633)3.04064351
14Pancreatic fibrosis (HP:0100732)3.03165675
15Parakeratosis (HP:0001036)3.01146376
16Patchy hypopigmentation of hair (HP:0011365)3.00660252
17Peripheral hypomyelination (HP:0007182)2.98552283
18Pancreatic cysts (HP:0001737)2.97559209
19Premature skin wrinkling (HP:0100678)2.97323011
20Akinesia (HP:0002304)2.92120898
21Anteriorly placed anus (HP:0001545)2.88459025
22Chronic hepatic failure (HP:0100626)2.87393067
23True hermaphroditism (HP:0010459)2.87055538
24Aqueductal stenosis (HP:0002410)2.83526647
25Termporal pattern (HP:0011008)2.77434884
26Insidious onset (HP:0003587)2.77434884
27Poor coordination (HP:0002370)2.67975682
28Abnormality of the labia minora (HP:0012880)2.67310964
29Abnormality of chromosome stability (HP:0003220)2.64364960
30Abolished electroretinogram (ERG) (HP:0000550)2.56716316
31Spastic gait (HP:0002064)2.55977193
32Hepatoblastoma (HP:0002884)2.53659310
33Abnormality of the renal cortex (HP:0011035)2.52656280
34Aplasia/Hypoplasia of the uvula (HP:0010293)2.51865785
35Abnormality of the renal medulla (HP:0100957)2.49860434
36Blue irides (HP:0000635)2.47516165
37Thyroid carcinoma (HP:0002890)2.45868118
38Gaze-evoked nystagmus (HP:0000640)2.44417612
39Renal cortical cysts (HP:0000803)2.42211283
40Intestinal atresia (HP:0011100)2.40876143
41Cerebral inclusion bodies (HP:0100314)2.37802247
42Widely spaced teeth (HP:0000687)2.35091189
43Midline defect of the nose (HP:0004122)2.29093152
44Drooling (HP:0002307)2.28816922
45Excessive salivation (HP:0003781)2.28816922
46Aplasia/Hypoplasia of the tibia (HP:0005772)2.22195643
47Onion bulb formation (HP:0003383)2.21985783
48Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.21824645
49Gait imbalance (HP:0002141)2.21471156
50Medial flaring of the eyebrow (HP:0010747)2.21392138
51Supranuclear gaze palsy (HP:0000605)2.20508359
52Genital tract atresia (HP:0001827)2.19516165
53Absent speech (HP:0001344)2.19303189
54Vaginal atresia (HP:0000148)2.19266890
55Intellectual disability, moderate (HP:0002342)2.17894202
56Hypoplastic pelvis (HP:0008839)2.16619590
57Cone-rod dystrophy (HP:0000548)2.16382642
58Meckel diverticulum (HP:0002245)2.15167158
59Stomach cancer (HP:0012126)2.14933420
60Thickened helices (HP:0000391)2.14594190
61Macroorchidism (HP:0000053)2.13938833
62Febrile seizures (HP:0002373)2.13618571
63Chin dimple (HP:0010751)2.13438439
64Pheochromocytoma (HP:0002666)2.13431681
65Abnormality of the ileum (HP:0001549)2.11370077
66Intention tremor (HP:0002080)2.11240942
67Dyschromatopsia (HP:0007641)2.10481386
68Astigmatism (HP:0000483)2.09170504
69Congenital sensorineural hearing impairment (HP:0008527)2.08869402
70Chromsome breakage (HP:0040012)2.08094813
71Small epiphyses (HP:0010585)2.07858589
72Sclerocornea (HP:0000647)2.06804966
73Coronal craniosynostosis (HP:0004440)2.06504647
74Aplasia/Hypoplasia of the tongue (HP:0010295)2.05540578
75Absent septum pellucidum (HP:0001331)2.05525345
76Tubulointerstitial nephritis (HP:0001970)2.05313304
77Specific learning disability (HP:0001328)2.05018094
78Bell-shaped thorax (HP:0001591)2.03813846
79Colon cancer (HP:0003003)2.03550500
80Ankle clonus (HP:0011448)2.03528908
81Esophageal atresia (HP:0002032)2.03337244
82Protruding tongue (HP:0010808)2.01579193
83Postaxial hand polydactyly (HP:0001162)2.01342402
84Megalencephaly (HP:0001355)1.97354313
85Morphological abnormality of the inner ear (HP:0011390)1.97008001
86Abnormality of salivation (HP:0100755)1.95343105
87Hypoplasia of the iris (HP:0007676)1.95278077
88Fair hair (HP:0002286)1.94732486
89Chromosomal breakage induced by crosslinking agents (HP:0003221)1.94092994
90Abnormality of the septum pellucidum (HP:0007375)1.93779703
91Abnormality of incisor morphology (HP:0011063)1.93498081
92Optic nerve hypoplasia (HP:0000609)1.92571929
93Gastrointestinal atresia (HP:0002589)1.92126894
94Lissencephaly (HP:0001339)1.91976434
95Duodenal stenosis (HP:0100867)1.91970104
96Small intestinal stenosis (HP:0012848)1.91970104
97Lower limb muscle weakness (HP:0007340)1.91696715
98Broad-based gait (HP:0002136)1.91689970
99Broad foot (HP:0001769)1.90975999
100Epiphyseal dysplasia (HP:0002656)1.90778586
101Medulloblastoma (HP:0002885)1.90012397
102Limb dystonia (HP:0002451)1.90006751
103Flat face (HP:0012368)1.89823484
104Dynein arm defect of respiratory motile cilia (HP:0012255)1.89721986
105Absent/shortened dynein arms (HP:0200106)1.89721986
106Neuroendocrine neoplasm (HP:0100634)1.89037491
107Sloping forehead (HP:0000340)1.88728860
108Postaxial foot polydactyly (HP:0001830)1.88618897
109Abnormality of the duodenum (HP:0002246)1.88163423
110Aplasia/Hypoplasia of the sternum (HP:0006714)1.87547666
111Glioma (HP:0009733)1.87267206
112Relative macrocephaly (HP:0004482)1.87157377
113Truncal obesity (HP:0001956)1.86612551
114Adrenal hypoplasia (HP:0000835)1.86274172
115Thyroiditis (HP:0100646)1.85953105
116Preaxial hand polydactyly (HP:0001177)1.85602542
117Pachygyria (HP:0001302)1.84924525
118Abnormality of the astrocytes (HP:0100707)1.83523007
119Astrocytoma (HP:0009592)1.83523007
120Methylmalonic acidemia (HP:0002912)1.83008794
121Narrow forehead (HP:0000341)1.82762742
122Aganglionic megacolon (HP:0002251)1.81672447
123Congenital primary aphakia (HP:0007707)1.79992177
124Decreased central vision (HP:0007663)1.79058156
125Scanning speech (HP:0002168)1.78618309
126Anencephaly (HP:0002323)1.78580989
127Short tibia (HP:0005736)1.78484212
128Cortical dysplasia (HP:0002539)1.78120573
129Hypothermia (HP:0002045)1.76209858
130Cerebellar dysplasia (HP:0007033)1.75920647
131Embryonal renal neoplasm (HP:0011794)1.75167176
132Inability to walk (HP:0002540)1.73953894
133Volvulus (HP:0002580)1.72994345
134Nephroblastoma (Wilms tumor) (HP:0002667)1.72924149
135Hypoplastic labia majora (HP:0000059)1.72894104
136Clumsiness (HP:0002312)1.72763286
137Labial hypoplasia (HP:0000066)1.71872940
138Abnormal lung lobation (HP:0002101)1.71299667
139Oligodactyly (hands) (HP:0001180)1.71243373
140Nephrogenic diabetes insipidus (HP:0009806)1.70432328
141Abnormality of chromosome segregation (HP:0002916)1.70117761
142Supernumerary spleens (HP:0009799)1.70047731
143Decreased testicular size (HP:0008734)1.67899392
144Thyroid-stimulating hormone excess (HP:0002925)1.67132752
145Mixed hearing impairment (HP:0000410)1.66557413
146Steppage gait (HP:0003376)1.66530524
147Hyperglycinemia (HP:0002154)1.66234546
148Bowel incontinence (HP:0002607)1.66013707
149Progressive cerebellar ataxia (HP:0002073)1.65725776
150Abnormality of vitamin B metabolism (HP:0004340)1.65701393
151Hypsarrhythmia (HP:0002521)1.64956210
152Type II lissencephaly (HP:0007260)1.64734155
153Prominent nasal bridge (HP:0000426)1.64658557
154Retinal dysplasia (HP:0007973)1.64052822
155Papillary thyroid carcinoma (HP:0002895)1.63913879
156Hypoplastic female external genitalia (HP:0012815)1.63150334
157Acute lymphatic leukemia (HP:0006721)1.63147220
158Progressive inability to walk (HP:0002505)1.62980172
159Abnormality of the preputium (HP:0100587)1.62502372
160Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.62388616
161Short foot (HP:0001773)1.62223150
162Cerebral hypomyelination (HP:0006808)1.62140310
163Renal hypoplasia (HP:0000089)1.61638818
164Clonus (HP:0002169)1.60918339
165Dysmetria (HP:0001310)1.60549275
166Nephronophthisis (HP:0000090)1.60513042
167Buphthalmos (HP:0000557)1.59220250
168Overriding aorta (HP:0002623)1.58674058
169Segmental peripheral demyelination/remyelination (HP:0003481)1.57888668
170Heterochromia iridis (HP:0001100)1.56875460
171Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.54503478
172Hyperventilation (HP:0002883)1.54340701
173Bifid scrotum (HP:0000048)1.53607860
174Infantile muscular hypotonia (HP:0008947)1.53524480
175Exotropia (HP:0000577)1.52802584
176Septo-optic dysplasia (HP:0100842)1.51758787
177Abnormal large intestine physiology (HP:0012700)1.51468938

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.07236708
2TNIK4.01989789
3MAP4K23.10815663
4OXSR12.82199324
5MARK12.76695456
6FGFR22.54980214
7PKN12.47432649
8BCR2.34898173
9CASK2.29494121
10EPHB12.25934516
11ACVR1B2.25900515
12ERBB32.08143453
13IRAK22.06600572
14PINK12.04757665
15TRIM282.03923982
16UHMK12.00669754
17WNK41.93078975
18MAPK131.91252676
19MKNK21.89939055
20BMPR1B1.77964904
21BRSK21.76837645
22CCNB11.74315565
23CSNK1A1L1.71756950
24ICK1.61701186
25INSRR1.47804231
26PBK1.44792568
27MET1.43220100
28DYRK21.42645108
29CSNK1G31.41610839
30TYRO31.41112866
31WNK11.40145822
32IRAK11.39664557
33IRAK41.38535848
34PLK41.37088857
35EPHA31.35182346
36CLK11.33819383
37BUB11.30968055
38YES11.27874285
39NUAK11.27451502
40WEE11.27034120
41DYRK31.23255872
42FRK1.22610166
43FES1.22370294
44CSNK1G21.22180626
45CSNK1G11.18523411
46FGR1.15838498
47NEK61.14901374
48SGK2231.09953200
49SGK4941.09953200
50PLK31.09064545
51ADRBK21.08474009
52TTK1.06981518
53PAK31.04402282
54MAPKAPK51.02545149
55NTRK10.96965060
56MAP2K40.95619462
57PRKCQ0.94598852
58CAMKK20.94455933
59BRD40.90727753
60PDGFRB0.89694479
61PLK10.89403152
62PRPF4B0.86984601
63CAMK2B0.86947560
64LIMK10.86894095
65SRPK10.86572068
66STK38L0.82304415
67NTRK20.80135191
68WNK30.79521938
69TLK10.79368142
70MKNK10.78847705
71AKT30.78122425
72BCKDK0.77675730
73RPS6KA50.76369452
74NEK20.75111164
75HIPK20.74892936
76ZAK0.74250415
77OBSCN0.73812439
78STK30.73306141
79PNCK0.72186266
80MARK20.70829105
81CAMK1G0.70527350
82CAMK2D0.70456962
83ROCK20.70080790
84PRKCG0.70080136
85MAP3K50.69013265
86MAP2K70.66558416
87NEK10.65762095
88PRKCE0.64609910
89EIF2AK20.64175327
90KSR10.63441571
91MINK10.62389333
92EPHA40.62306872
93FYN0.62039882
94MAP3K20.61963680
95MAPK150.61895606
96CSNK1D0.61580144
97CDK30.61249717
98ATR0.59231923
99SGK20.59086373
100CDK50.57718012
101MAP3K40.57187969
102CSF1R0.57091454
103ERBB20.56363009
104PRKG10.54949604
105GSK3A0.53954711
106RPS6KA40.53736011
107INSR0.52845194
108MST40.52445893
109CDK80.51560771
110MAP3K60.51542146
111EIF2AK30.51265668
112NTRK30.50715643
113MELK0.50556000
114TRPM70.50180194
115CHEK20.49807942
116CAMK2A0.49547416
117ROCK10.48791747
118SGK10.48279457
119TAOK30.48194014
120BRSK10.48183369
121PAK60.47104666
122PIK3CA0.45913236
123TSSK60.45520844
124VRK10.45395305
125BMPR20.44815026
126AURKB0.44059316
127FGFR10.43799783
128TGFBR10.43471097
129MAP3K140.42980012
130DYRK1A0.40574214
131NLK0.38224901
132GRK10.37767471
133DYRK1B0.37423081
134PLK20.35722978
135ITK0.35544281
136EPHB20.35319886
137CAMK40.35205533
138PRKACB0.35062357
139CDK140.34739474
140LATS10.34570063
141CDK10.33030652
142ATM0.32745068
143CDC70.29329882

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.13763016
2Steroid biosynthesis_Homo sapiens_hsa001003.87327053
3Ether lipid metabolism_Homo sapiens_hsa005653.18598672
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.62482289
5Axon guidance_Homo sapiens_hsa043602.42611817
6Homologous recombination_Homo sapiens_hsa034402.42072118
7Protein export_Homo sapiens_hsa030602.38794803
8Butanoate metabolism_Homo sapiens_hsa006502.21066832
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.15576767
10Propanoate metabolism_Homo sapiens_hsa006402.11443864
11Fatty acid elongation_Homo sapiens_hsa000622.11384568
12Sulfur metabolism_Homo sapiens_hsa009202.09571040
13Maturity onset diabetes of the young_Homo sapiens_hsa049501.94667741
14Sphingolipid metabolism_Homo sapiens_hsa006001.83780207
15Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.82220573
16Serotonergic synapse_Homo sapiens_hsa047261.70874526
17Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.62047635
18Selenocompound metabolism_Homo sapiens_hsa004501.62016232
19RNA degradation_Homo sapiens_hsa030181.57128908
20Mismatch repair_Homo sapiens_hsa034301.55301967
21Glutamatergic synapse_Homo sapiens_hsa047241.51333202
22Cell cycle_Homo sapiens_hsa041101.46257245
23Alcoholism_Homo sapiens_hsa050341.43711405
24Systemic lupus erythematosus_Homo sapiens_hsa053221.41943497
25Renal cell carcinoma_Homo sapiens_hsa052111.40600746
26Non-homologous end-joining_Homo sapiens_hsa034501.39997877
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35486365
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34222003
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.30127217
30Olfactory transduction_Homo sapiens_hsa047401.29765323
31Cholinergic synapse_Homo sapiens_hsa047251.20492914
32Phototransduction_Homo sapiens_hsa047441.17787093
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.13998654
34Oxidative phosphorylation_Homo sapiens_hsa001901.13318953
35Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.12472617
36Oocyte meiosis_Homo sapiens_hsa041141.11974737
37Regulation of autophagy_Homo sapiens_hsa041401.09569381
38Circadian rhythm_Homo sapiens_hsa047101.06024636
39Sphingolipid signaling pathway_Homo sapiens_hsa040711.03626736
40Linoleic acid metabolism_Homo sapiens_hsa005911.01722631
41Type II diabetes mellitus_Homo sapiens_hsa049301.01310424
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.01117738
43Peroxisome_Homo sapiens_hsa041461.00822133
44Fatty acid biosynthesis_Homo sapiens_hsa000611.00697759
45Parkinsons disease_Homo sapiens_hsa050121.00541866
46Vibrio cholerae infection_Homo sapiens_hsa051101.00475640
47Choline metabolism in cancer_Homo sapiens_hsa052311.00357932
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.99286287
49ErbB signaling pathway_Homo sapiens_hsa040120.99125151
50Prostate cancer_Homo sapiens_hsa052150.98545355
51Morphine addiction_Homo sapiens_hsa050320.98205144
52Nucleotide excision repair_Homo sapiens_hsa034200.96976433
53RNA transport_Homo sapiens_hsa030130.96064151
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95188461
55Long-term depression_Homo sapiens_hsa047300.95095671
56Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94904694
57GABAergic synapse_Homo sapiens_hsa047270.94845790
58Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93963099
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93783497
60Ras signaling pathway_Homo sapiens_hsa040140.92443307
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91122476
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.90745525
63Dopaminergic synapse_Homo sapiens_hsa047280.89085756
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88895863
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88390558
66Dorso-ventral axis formation_Homo sapiens_hsa043200.87679323
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.84660614
68Tight junction_Homo sapiens_hsa045300.83005807
69TGF-beta signaling pathway_Homo sapiens_hsa043500.80623079
70Huntingtons disease_Homo sapiens_hsa050160.80297281
71Caffeine metabolism_Homo sapiens_hsa002320.79522790
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79025562
73Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.78344887
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77764936
75RNA polymerase_Homo sapiens_hsa030200.75835732
76Hippo signaling pathway_Homo sapiens_hsa043900.75474592
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74233936
78Colorectal cancer_Homo sapiens_hsa052100.74211681
79Fatty acid metabolism_Homo sapiens_hsa012120.73882343
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71077878
81Ovarian steroidogenesis_Homo sapiens_hsa049130.70934293
82Basal transcription factors_Homo sapiens_hsa030220.70358143
83Circadian entrainment_Homo sapiens_hsa047130.69931712
84p53 signaling pathway_Homo sapiens_hsa041150.69919301
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69515435
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69323676
87MicroRNAs in cancer_Homo sapiens_hsa052060.69286276
88Taste transduction_Homo sapiens_hsa047420.68758120
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68265863
90Renin secretion_Homo sapiens_hsa049240.67672509
91Collecting duct acid secretion_Homo sapiens_hsa049660.67544722
92Lysine degradation_Homo sapiens_hsa003100.67470618
93Cocaine addiction_Homo sapiens_hsa050300.65854182
94Nitrogen metabolism_Homo sapiens_hsa009100.65722931
95T cell receptor signaling pathway_Homo sapiens_hsa046600.65144673
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64351070
97Pancreatic secretion_Homo sapiens_hsa049720.63646625
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.63431403
99Wnt signaling pathway_Homo sapiens_hsa043100.63397967
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.63225299
101Tryptophan metabolism_Homo sapiens_hsa003800.62874745
102Fanconi anemia pathway_Homo sapiens_hsa034600.62799691
103Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62720128
104Purine metabolism_Homo sapiens_hsa002300.62065616
105Pancreatic cancer_Homo sapiens_hsa052120.61932458
106Insulin secretion_Homo sapiens_hsa049110.61074736
107B cell receptor signaling pathway_Homo sapiens_hsa046620.59355036
108Hedgehog signaling pathway_Homo sapiens_hsa043400.59156899
109Endocytosis_Homo sapiens_hsa041440.57825505
110Spliceosome_Homo sapiens_hsa030400.57187529
111Nicotine addiction_Homo sapiens_hsa050330.53664485
112Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52928349
113Retinol metabolism_Homo sapiens_hsa008300.52266107
114ABC transporters_Homo sapiens_hsa020100.51541837
115Endometrial cancer_Homo sapiens_hsa052130.51088809
116Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50938937
117Glioma_Homo sapiens_hsa052140.50650374
118Phagosome_Homo sapiens_hsa041450.50565544
119Viral myocarditis_Homo sapiens_hsa054160.49708429
120Primary bile acid biosynthesis_Homo sapiens_hsa001200.49577165
121Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49046182
122Basal cell carcinoma_Homo sapiens_hsa052170.48689171
123One carbon pool by folate_Homo sapiens_hsa006700.47842519
124MAPK signaling pathway_Homo sapiens_hsa040100.47470789
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46918829
126Alzheimers disease_Homo sapiens_hsa050100.46385070
127Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46293977
128Chemokine signaling pathway_Homo sapiens_hsa040620.44128710
129PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43551291
130ECM-receptor interaction_Homo sapiens_hsa045120.43543638
131Cardiac muscle contraction_Homo sapiens_hsa042600.43459091
132beta-Alanine metabolism_Homo sapiens_hsa004100.43268722
133Metabolic pathways_Homo sapiens_hsa011000.42395025
134Rheumatoid arthritis_Homo sapiens_hsa053230.41711057
135Mineral absorption_Homo sapiens_hsa049780.41425468
136cAMP signaling pathway_Homo sapiens_hsa040240.41353352
137Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41344711
138N-Glycan biosynthesis_Homo sapiens_hsa005100.40982936
139Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40674102
140Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40611556
141Focal adhesion_Homo sapiens_hsa045100.40349073
142Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40223651
143mRNA surveillance pathway_Homo sapiens_hsa030150.40206659
144Gap junction_Homo sapiens_hsa045400.39205527
145Platelet activation_Homo sapiens_hsa046110.39182201
146Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38771978
147Arachidonic acid metabolism_Homo sapiens_hsa005900.38646710
148Autoimmune thyroid disease_Homo sapiens_hsa053200.38399238
149GnRH signaling pathway_Homo sapiens_hsa049120.37785211
150Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37632360
151Long-term potentiation_Homo sapiens_hsa047200.37445166
152Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37413696
153Melanogenesis_Homo sapiens_hsa049160.37141889
154Melanoma_Homo sapiens_hsa052180.35777653
155Amphetamine addiction_Homo sapiens_hsa050310.34528922
156Hepatitis C_Homo sapiens_hsa051600.34526949

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