LCP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an adapter protein that acts as a substrate of the T cell antigen receptor (TCR)-activated protein tyrosine kinase pathway. The encoded protein associates with growth factor receptor bound protein 2, and is thought to play a role TCR-mediated intracellular signal transduction. A similar protein in mouse plays a role in normal T-cell development and activation. Mice lacking this gene show subcutaneous and intraperitoneal fetal hemorrhaging, dysfunctional platelets and impaired viability. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.09054803
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.91137478
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.91137478
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.84813875
5leukocyte aggregation (GO:0070486)4.70292023
6regulation of gamma-delta T cell differentiation (GO:0045586)4.64203060
7positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.62952767
8negative T cell selection (GO:0043383)4.59783070
9regulation of gamma-delta T cell activation (GO:0046643)4.54425653
10antigen processing and presentation of endogenous antigen (GO:0019883)4.45909773
11negative thymic T cell selection (GO:0045060)4.44446588
12interferon-gamma production (GO:0032609)4.38973504
13regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.38924535
14positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.38068525
15regulation of B cell receptor signaling pathway (GO:0050855)4.35238850
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.34212203
17negative regulation of cell killing (GO:0031342)4.34212203
18regulation of interleukin-12 biosynthetic process (GO:0045075)4.24738470
19positive thymic T cell selection (GO:0045059)4.14964215
20modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.07497354
21positive regulation by organism of defense response of other organism involved in symbiotic interact4.07497354
22modulation by symbiont of host immune response (GO:0052553)4.07497354
23positive regulation by symbiont of host defense response (GO:0052509)4.07497354
24modulation by symbiont of host defense response (GO:0052031)4.07497354
25modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.07497354
26T cell migration (GO:0072678)4.07178538
27detection of other organism (GO:0098543)4.02119446
28regulation of isotype switching to IgG isotypes (GO:0048302)3.95638494
29tolerance induction (GO:0002507)3.90494767
30detection of bacterium (GO:0016045)3.78578346
31response to interleukin-15 (GO:0070672)3.78465745
32positive T cell selection (GO:0043368)3.78448991
33positive regulation of immunoglobulin mediated immune response (GO:0002891)3.70494141
34positive regulation of B cell mediated immunity (GO:0002714)3.70494141
35negative regulation of lymphocyte mediated immunity (GO:0002707)3.67730061
36regulation of alpha-beta T cell proliferation (GO:0046640)3.62478559
37positive regulation of isotype switching (GO:0045830)3.61318614
38cellular response to interleukin-15 (GO:0071350)3.58315685
39regulation of interleukin-2 biosynthetic process (GO:0045076)3.57214432
40myeloid dendritic cell activation (GO:0001773)3.56827037
41thymic T cell selection (GO:0045061)3.55756295
42neutrophil activation (GO:0042119)3.55159334
43negative regulation of interleukin-12 production (GO:0032695)3.54047345
44positive regulation of alpha-beta T cell proliferation (GO:0046641)3.53586753
45T cell selection (GO:0045058)3.53197834
46positive regulation of humoral immune response (GO:0002922)3.47818675
47granulocyte activation (GO:0036230)3.46875590
48germinal center formation (GO:0002467)3.45897921
49response to peptidoglycan (GO:0032494)3.42204149
50detection of external biotic stimulus (GO:0098581)3.42002912
51regulation of tolerance induction (GO:0002643)3.41831672
52detection of molecule of bacterial origin (GO:0032490)3.40938597
53myeloid dendritic cell differentiation (GO:0043011)3.40811292
54positive regulation of B cell differentiation (GO:0045579)3.39837806
55defense response to protozoan (GO:0042832)3.36686872
56lipopolysaccharide-mediated signaling pathway (GO:0031663)3.36175507
57positive regulation of interleukin-2 production (GO:0032743)3.35148103
58positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.34716222
59immunoglobulin mediated immune response (GO:0016064)3.34619380
60regulation of B cell differentiation (GO:0045577)3.34555903
61response to type I interferon (GO:0034340)3.33769676
62negative regulation of leukocyte mediated immunity (GO:0002704)3.32410150
63type I interferon signaling pathway (GO:0060337)3.31670946
64cellular response to type I interferon (GO:0071357)3.31670946
65NIK/NF-kappaB signaling (GO:0038061)3.30083805
66neutrophil activation involved in immune response (GO:0002283)3.27605287
67response to protozoan (GO:0001562)3.26729843
68regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.24800310
69regulation of regulatory T cell differentiation (GO:0045589)3.23630049
70regulation of B cell mediated immunity (GO:0002712)3.22676093
71regulation of immunoglobulin mediated immune response (GO:0002889)3.21535905
72response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.20081086
73microglial cell activation (GO:0001774)3.19928203
74positive regulation of tolerance induction (GO:0002645)3.19798276
75negative regulation of erythrocyte differentiation (GO:0045647)3.19391527
76activated T cell proliferation (GO:0050798)3.17310571
77positive regulation of DNA recombination (GO:0045911)3.16288253
78leukocyte cell-cell adhesion (GO:0007159)3.13947574
79negative regulation of cytokine production involved in immune response (GO:0002719)3.11938219
80interferon-gamma-mediated signaling pathway (GO:0060333)3.11830499
81detection of biotic stimulus (GO:0009595)3.11493361
82response to muramyl dipeptide (GO:0032495)3.10224735
83positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.09361588
84* T cell receptor signaling pathway (GO:0050852)3.08656175
85regulation of interferon-alpha production (GO:0032647)3.06516021
86T cell costimulation (GO:0031295)3.05855296
87macrophage activation (GO:0042116)3.05240302
88positive regulation of interferon-alpha production (GO:0032727)3.05080429
89lymphocyte costimulation (GO:0031294)3.04075152
90negative regulation of T cell mediated immunity (GO:0002710)3.03773422
91regulation of T cell receptor signaling pathway (GO:0050856)3.02386737
92regulation of isotype switching (GO:0045191)2.99531437
93regulation of interferon-beta biosynthetic process (GO:0045357)2.99385493
94regulation of chronic inflammatory response (GO:0002676)2.98355739
95B cell mediated immunity (GO:0019724)2.97779973
96* antigen receptor-mediated signaling pathway (GO:0050851)2.97717306
97myeloid cell activation involved in immune response (GO:0002275)2.97534130
98regulation of mast cell degranulation (GO:0043304)2.97467450
99regulation of T cell mediated cytotoxicity (GO:0001914)2.94328561
100neutrophil mediated immunity (GO:0002446)2.94301571
101regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.93613504
102* mast cell activation (GO:0045576)2.93375611
103regulation of T cell tolerance induction (GO:0002664)2.93018171
104regulation of dendritic cell antigen processing and presentation (GO:0002604)2.92659055
105response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.91870516
106response to host (GO:0075136)2.91870516
107response to host defenses (GO:0052200)2.91870516
108antigen processing and presentation via MHC class Ib (GO:0002475)2.91252057
109regulation of response to interferon-gamma (GO:0060330)2.90611559
110T cell homeostasis (GO:0043029)2.90146563
111cellular extravasation (GO:0045123)2.89488725
112positive regulation of cytokine biosynthetic process (GO:0042108)2.89173796
113respiratory burst (GO:0045730)2.86279671
114regulation of T-helper 1 cell differentiation (GO:0045625)2.85993046
115negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.84948504
116B cell receptor signaling pathway (GO:0050853)2.83532638
117leukocyte degranulation (GO:0043299)2.83377800
118regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.83206697
119regulation of natural killer cell mediated immunity (GO:0002715)2.83206697
120regulation of immunoglobulin secretion (GO:0051023)2.82853502
121positive regulation of interferon-gamma production (GO:0032729)2.82213277
122positive regulation of chemokine biosynthetic process (GO:0045080)2.81998757
123JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.81465024
124regulation of leukocyte mediated cytotoxicity (GO:0001910)2.81075977
125cellular response to interferon-beta (GO:0035458)2.80763589
126Arp2/3 complex-mediated actin nucleation (GO:0034314)2.80368302
127negative regulation of innate immune response (GO:0045824)2.79723728
128positive regulation of mast cell activation (GO:0033005)2.79189751
129mature B cell differentiation (GO:0002335)2.78987533
130regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.78890528
131macrophage activation involved in immune response (GO:0002281)2.78720834
132regulation of interleukin-12 production (GO:0032655)2.78163590
133regulation of vitamin D biosynthetic process (GO:0060556)2.77977646
134regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.77968663
135T cell proliferation (GO:0042098)2.77805931
136response to host immune response (GO:0052572)2.77803629

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.03432553
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.32077504
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.02976581
4* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.95689449
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.50847897
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.15140712
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.68453024
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.55339812
9* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.37845092
10E2F7_22180533_ChIP-Seq_HELA_Human3.20737926
11* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.19817461
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.16245062
13* IRF8_27001747_Chip-Seq_BMDM_Mouse3.09909706
14EGR1_19374776_ChIP-ChIP_THP-1_Human3.06767222
15* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.02411654
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.86783824
17* RUNX_20019798_ChIP-Seq_JUKART_Human2.80856252
18SCL_19346495_ChIP-Seq_HPC-7_Human2.80152127
19* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.76263907
20MYB_26560356_Chip-Seq_TH2_Human2.74798837
21* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.66203496
22* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.45890431
23MYC_22102868_ChIP-Seq_BL_Human2.40765551
24* SPI1_23547873_ChIP-Seq_NB4_Human2.39488142
25MAF_26560356_Chip-Seq_TH1_Human2.36094577
26* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.35283692
27MYB_26560356_Chip-Seq_TH1_Human2.27019470
28NOTCH1_21737748_ChIP-Seq_TLL_Human2.19358728
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.06728371
30VDR_21846776_ChIP-Seq_THP-1_Human2.06633740
31* RUNX1_22412390_ChIP-Seq_EML_Mouse2.06078706
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.00025000
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.98682219
34* UTX_26944678_Chip-Seq_JUKART_Human1.97636643
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.95941604
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.95840184
37* VDR_24763502_ChIP-Seq_THP-1_Human1.85848212
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.81941663
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.73652491
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.68642657
41* GATA3_27048872_Chip-Seq_THYMUS_Human1.65618106
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.63863288
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.63219009
44* SPI1_23127762_ChIP-Seq_K562_Human1.60416253
45* PU_27001747_Chip-Seq_BMDM_Mouse1.58625759
46TCF7_22412390_ChIP-Seq_EML_Mouse1.58572431
47MAF_26560356_Chip-Seq_TH2_Human1.53882092
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51910454
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.51036512
50LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.49972623
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.47585565
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.43332719
53* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.40565667
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.39650412
55* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39263829
56* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27956777
57GATA3_26560356_Chip-Seq_TH2_Human1.27462653
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25701368
59KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24853682
60GATA1_19941826_ChIP-Seq_K562_Human1.23687140
61GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.20594043
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18176744
63GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17071766
64STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17002959
65* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15103893
66STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.14932930
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14737123
68KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12959209
69GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11021263
70SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10299371
71STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09769653
72VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07776864
73GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06211913
74* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05287881
75* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05143485
76* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.05142891
77* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04926510
78* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01560146
79KDM2B_26808549_Chip-Seq_JURKAT_Human1.00507400
80FOXM1_23109430_ChIP-Seq_U2OS_Human0.98263016
81VDR_24787735_ChIP-Seq_THP-1_Human0.98201818
82* GATA1_19941827_ChIP-Seq_MEL_Mouse0.95737617
83* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95205445
84VDR_23849224_ChIP-Seq_CD4+_Human0.94566209
85KDM2B_26808549_Chip-Seq_DND41_Human0.93007630
86E2F4_17652178_ChIP-ChIP_JURKAT_Human0.90889543
87GATA1_22025678_ChIP-Seq_K562_Human0.90800004
88* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90081613
89NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88499027
90EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.88082641
91* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.87137247
92SMAD_19615063_ChIP-ChIP_OVARY_Human0.86989446
93BCL6_27268052_Chip-Seq_Bcells_Human0.83287427
94CIITA_25753668_ChIP-Seq_RAJI_Human0.81467153
95ELK3_25401928_ChIP-Seq_HUVEC_Human0.81378775
96LXR_22292898_ChIP-Seq_THP-1_Human0.79914776
97* NCOR1_26117541_ChIP-Seq_K562_Human0.79268996
98KDM2B_26808549_Chip-Seq_SUP-B15_Human0.79035707
99* FOXP3_21729870_ChIP-Seq_TREG_Human0.77771610
100THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.75137591
101BCOR_27268052_Chip-Seq_Bcells_Human0.75131580
102IKZF1_21737484_ChIP-ChIP_HCT116_Human0.75097252
103* ELK1_19687146_ChIP-ChIP_HELA_Human0.74584042
104ETS1_22383799_ChIP-Seq_G1ME_Mouse0.74563744
105GATA2_21666600_ChIP-Seq_HMVEC_Human0.73523201
106TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72993666
107* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.72172533
108FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.72110661
109TFEB_21752829_ChIP-Seq_HELA_Human0.71344801
110TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.70142484
111GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69693536
112* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68741608
113SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.66683437
114GATA2_19941826_ChIP-Seq_K562_Human0.64671105
115RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63657229

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.25327303
2MP0005671_abnormal_response_to3.93290905
3MP0009785_altered_susceptibility_to3.51443878
4MP0003436_decreased_susceptibility_to3.46889264
5MP0000685_abnormal_immune_system3.25671942
6* MP0003763_abnormal_thymus_physiology3.17922570
7* MP0005000_abnormal_immune_tolerance3.08635897
8* MP0001800_abnormal_humoral_immune2.99324313
9MP0006082_CNS_inflammation2.97802025
10MP0005387_immune_system_phenotype2.93318693
11MP0001790_abnormal_immune_system2.93318693
12MP0002148_abnormal_hypersensitivity_rea2.89637365
13MP0005025_abnormal_response_to2.89061114
14MP0003724_increased_susceptibility_to2.79212940
15* MP0002723_abnormal_immune_serum2.77310737
16MP0003303_peritoneal_inflammation2.75358903
17* MP0002452_abnormal_antigen_presenting2.73897226
18MP0002419_abnormal_innate_immunity2.72013568
19* MP0002420_abnormal_adaptive_immunity2.64913284
20* MP0001819_abnormal_immune_cell2.63844092
21MP0002405_respiratory_system_inflammati2.47125609
22MP0009333_abnormal_splenocyte_physiolog2.45864289
23MP0002396_abnormal_hematopoietic_system2.39423982
24* MP0002398_abnormal_bone_marrow2.39146658
25* MP0005464_abnormal_platelet_physiology2.20436548
26MP0002166_altered_tumor_susceptibility2.17609685
27MP0003300_gastrointestinal_ulcer2.17422055
28MP0001853_heart_inflammation2.16844728
29* MP0000716_abnormal_immune_system2.16237885
30MP0002006_tumorigenesis2.10160777
31MP0010155_abnormal_intestine_physiology2.09387144
32MP0004510_myositis2.09007522
33MP0000689_abnormal_spleen_morphology1.98596272
34MP0004947_skin_inflammation1.94433853
35* MP0002722_abnormal_immune_system1.92686438
36MP0001873_stomach_inflammation1.87843685
37MP0001845_abnormal_inflammatory_respons1.87662116
38* MP0002429_abnormal_blood_cell1.80562013
39MP0004808_abnormal_hematopoietic_stem1.75879620
40* MP0000703_abnormal_thymus_morphology1.75686535
41MP0001533_abnormal_skeleton_physiology1.69464367
42MP0003866_abnormal_defecation1.67156229
43MP0005397_hematopoietic_system_phenotyp1.59503545
44MP0001545_abnormal_hematopoietic_system1.59503545
45MP0000465_gastrointestinal_hemorrhage1.58295526
46MP0002933_joint_inflammation1.51024984
47MP0009278_abnormal_bone_marrow1.48765531
48MP0005058_abnormal_lysosome_morphology1.45366684
49MP0008469_abnormal_protein_level1.43740752
50MP0005451_abnormal_body_composition1.43651362
51MP0005310_abnormal_salivary_gland1.39441365
52MP0000858_altered_metastatic_potential1.38860951
53MP0003448_altered_tumor_morphology1.35681667
54MP0005174_abnormal_tail_pigmentation1.34089123
55MP0009764_decreased_sensitivity_to1.33560812
56MP0000490_abnormal_crypts_of1.29260313
57MP0008004_abnormal_stomach_pH1.27440594
58MP0003172_abnormal_lysosome_physiology1.27157062
59MP0008260_abnormal_autophagy1.20876882
60MP0000343_altered_response_to1.13002266
61MP0001851_eye_inflammation1.12769318
62MP0002998_abnormal_bone_remodeling1.08996609
63MP0002132_abnormal_respiratory_system1.03183506
64MP0005075_abnormal_melanosome_morpholog1.02443404
65MP0003656_abnormal_erythrocyte_physiolo1.01826446
66MP0003191_abnormal_cellular_cholesterol1.01221911
67MP0008057_abnormal_DNA_replication0.97933589
68MP0003690_abnormal_glial_cell0.97288629
69MP0005164_abnormal_response_to0.94805357
70MP0004883_abnormal_blood_vessel0.93771440
71MP0000015_abnormal_ear_pigmentation0.88090271
72MP0006054_spinal_hemorrhage0.86773796
73MP0003075_altered_response_to0.86128592
74MP0009763_increased_sensitivity_to0.86028738
75MP0002019_abnormal_tumor_incidence0.84838017
76MP0005166_decreased_susceptibility_to0.84631851
77MP0005167_abnormal_blood-brain_barrier0.83802706
78MP0000569_abnormal_digit_pigmentation0.79465503
79MP0003183_abnormal_peptide_metabolism0.79127984
80MP0002332_abnormal_exercise_endurance0.78925283
81MP0010307_abnormal_tumor_latency0.78113152
82MP0005390_skeleton_phenotype0.75783723
83MP0004381_abnormal_hair_follicle0.72420733
84MP0000604_amyloidosis0.71454582
85MP0003828_pulmonary_edema0.70475671
86MP0008007_abnormal_cellular_replicative0.69888485
87MP0002277_abnormal_respiratory_mucosa0.68205098
88MP0000249_abnormal_blood_vessel0.66478336
89MP0000371_diluted_coat_color0.65516777
90MP0001663_abnormal_digestive_system0.65436806
91MP0009765_abnormal_xenobiotic_induced0.65146590
92MP0002095_abnormal_skin_pigmentation0.65133393
93MP0003795_abnormal_bone_structure0.65081096
94MP0005023_abnormal_wound_healing0.64688149
95MP0003806_abnormal_nucleotide_metabolis0.62852646
96MP0005076_abnormal_cell_differentiation0.61562786
97MP0010352_gastrointestinal_tract_polyps0.58492077
98MP0004782_abnormal_surfactant_physiolog0.57995676
99MP0003693_abnormal_embryo_hatching0.57224184
100MP0002254_reproductive_system_inflammat0.55601871
101MP0008874_decreased_physiological_sensi0.54824618
102MP0004130_abnormal_muscle_cell0.53900257
103MP0000920_abnormal_myelination0.53761127
104MP0010094_abnormal_chromosome_stability0.53402813
105MP0003077_abnormal_cell_cycle0.50909596
106MP0008873_increased_physiological_sensi0.50708425
107MP0002138_abnormal_hepatobiliary_system0.50101887
108MP0000313_abnormal_cell_death0.49935917
109MP0005535_abnormal_body_temperature0.49822604
110MP0002009_preneoplasia0.49701454
111MP0003943_abnormal_hepatobiliary_system0.49521296
112MP0003091_abnormal_cell_migration0.49038991
113MP0003221_abnormal_cardiomyocyte_apopto0.48942533
114MP0002136_abnormal_kidney_physiology0.48578266
115MP0009840_abnormal_foam_cell0.46089790
116MP0003453_abnormal_keratinocyte_physiol0.45275035
117MP0008058_abnormal_DNA_repair0.44975488
118MP0003045_fibrosis0.44662522
119MP0000609_abnormal_liver_physiology0.43010497

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.77340896
2Elevated erythrocyte sedimentation rate (HP:0003565)5.60586391
3Recurrent abscess formation (HP:0002722)5.57792170
4Stomatitis (HP:0010280)5.50622038
5Myositis (HP:0100614)5.09200083
6Recurrent bacterial skin infections (HP:0005406)4.87832730
7T lymphocytopenia (HP:0005403)4.62193904
8Recurrent fungal infections (HP:0002841)4.59439793
9Abnormality of T cell number (HP:0011839)4.55381435
10Optic neuritis (HP:0100653)4.39669847
11Retrobulbar optic neuritis (HP:0100654)4.39669847
12Orchitis (HP:0100796)4.30072980
13Mediastinal lymphadenopathy (HP:0100721)4.17587336
14Recurrent viral infections (HP:0004429)4.14949456
15Abnormality of T cells (HP:0002843)3.86990912
16IgM deficiency (HP:0002850)3.71795481
17Obstructive lung disease (HP:0006536)3.67673963
18Chronic obstructive pulmonary disease (HP:0006510)3.67673963
19Recurrent gram-negative bacterial infections (HP:0005420)3.62998685
20Chronic otitis media (HP:0000389)3.61351375
21Severe combined immunodeficiency (HP:0004430)3.60415439
22Recurrent skin infections (HP:0001581)3.58822027
23Vasculitis (HP:0002633)3.57678980
24Panhypogammaglobulinemia (HP:0003139)3.52538683
25Chronic mucocutaneous candidiasis (HP:0002728)3.52416228
26Recurrent cutaneous fungal infections (HP:0011370)3.52416228
27Abnormality of macrophages (HP:0004311)3.49185564
28Increased IgM level (HP:0003496)3.48660281
29Autoimmune thrombocytopenia (HP:0001973)3.46114084
30Combined immunodeficiency (HP:0005387)3.37473166
31Meningitis (HP:0001287)3.37191079
32Recurrent bronchitis (HP:0002837)3.28871544
33IgG deficiency (HP:0004315)3.28046773
34Leukocytosis (HP:0001974)3.24588581
35Pulmonary infiltrates (HP:0002113)3.22705628
36Pustule (HP:0200039)3.21533035
37Gingivitis (HP:0000230)3.09022809
38Chronic diarrhea (HP:0002028)3.08402945
39Abnormality of T cell physiology (HP:0011840)3.06976801
40Abnormal delayed hypersensitivity skin test (HP:0002963)3.06611455
41B lymphocytopenia (HP:0010976)3.04858068
42Abnormality of B cell number (HP:0010975)3.04858068
43Nasal polyposis (HP:0100582)3.03571271
44Arterial thrombosis (HP:0004420)3.02992797
45Petechiae (HP:0000967)3.02322787
46Thrombocytosis (HP:0001894)3.00464656
47Eosinophilia (HP:0001880)2.98525449
48Hemoptysis (HP:0002105)2.97420226
49Abnormality of eosinophils (HP:0001879)2.94236765
50Keratoconjunctivitis sicca (HP:0001097)2.91738082
51Thyroiditis (HP:0100646)2.90231337
52Abnormality of liposaccharide metabolism (HP:0010968)2.89621329
53Abnormality of glycosphingolipid metabolism (HP:0004343)2.89621329
54Abnormality of glycolipid metabolism (HP:0010969)2.89621329
55Abnormality of the prostate (HP:0008775)2.77360119
56Granulocytopenia (HP:0001913)2.76454747
57Periodontitis (HP:0000704)2.73229071
58Prolonged bleeding time (HP:0003010)2.73172203
59IgA deficiency (HP:0002720)2.72968440
60Gingival bleeding (HP:0000225)2.69426809
61Lymphopenia (HP:0001888)2.68162958
62Epistaxis (HP:0000421)2.66569304
63Abnormality of the nasal mucosa (HP:0000433)2.66218977
64Systemic lupus erythematosus (HP:0002725)2.65252600
65Keratoconjunctivitis (HP:0001096)2.64229262
66Abnormality of cells of the lymphoid lineage (HP:0012140)2.62319155
67Spontaneous hematomas (HP:0007420)2.59480732
68Vacuolated lymphocytes (HP:0001922)2.59102454
69Encephalitis (HP:0002383)2.59098200
70Gastrointestinal infarctions (HP:0005244)2.57677811
71Autoimmune hemolytic anemia (HP:0001890)2.56949253
72Hypergammaglobulinemia (HP:0010702)2.54422089
73Episodic fever (HP:0001954)2.50850337
74Abnormality of the fingertips (HP:0001211)2.50234324
75Joint swelling (HP:0001386)2.50190885
76Inflammation of the large intestine (HP:0002037)2.49885677
77Lymphoma (HP:0002665)2.42413455
78Cellulitis (HP:0100658)2.41455850
79Loss of speech (HP:0002371)2.39215199
80Chest pain (HP:0100749)2.38322995
81Gastrointestinal inflammation (HP:0004386)2.38066777
82Increased neuronal autofluorescent lipopigment (HP:0002074)2.34927335
83Interstitial pulmonary disease (HP:0006530)2.29633392
84Amyloidosis (HP:0011034)2.26860958
85Increased cerebral lipofuscin (HP:0011813)2.23662091
86Basal ganglia calcification (HP:0002135)2.22931041
87Colitis (HP:0002583)2.20567447
88Increased serum ferritin (HP:0003281)2.19060122
89Hypochromic anemia (HP:0001931)2.18832139
90Abnormality of the pleura (HP:0002103)2.16912320
91Polyneuropathy (HP:0001271)2.16650324
92Vertigo (HP:0002321)2.14274535
93Dysostosis multiplex (HP:0000943)2.12774556
94Purpura (HP:0000979)2.12015383
95Hypoplasia of the thymus (HP:0000778)2.10647341
96Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.10381284
97Acute myeloid leukemia (HP:0004808)2.10305707
98Sepsis (HP:0100806)2.09040623
99Increased IgE level (HP:0003212)2.08264782
100Gangrene (HP:0100758)2.08139366
101Pulmonary embolism (HP:0002204)2.08112323
102Urticaria (HP:0001025)2.08030949
103Osteomyelitis (HP:0002754)2.07701791
104Agammaglobulinemia (HP:0004432)2.04742874
105Amaurosis fugax (HP:0100576)2.03294721
106Recurrent sinusitis (HP:0011108)2.02015478
107Keratitis (HP:0000491)2.01015199
108Prostate neoplasm (HP:0100787)2.00493263
109Abnormal platelet function (HP:0011869)1.99666955
110Impaired platelet aggregation (HP:0003540)1.99666955
111Abnormality of iron homeostasis (HP:0011031)1.98800656
112Cheilitis (HP:0100825)1.98790568
113Recurrent pneumonia (HP:0006532)1.98719844
114Gastrointestinal stroma tumor (HP:0100723)1.98444227
115Hematochezia (HP:0002573)1.97817296
116Abnormality of the endocardium (HP:0004306)1.97207659
117Slow saccadic eye movements (HP:0000514)1.96803094
118Glomerulopathy (HP:0100820)1.95885893
119Peritonitis (HP:0002586)1.95565431
120Anorexia (HP:0002039)1.95401058

Predicted kinase interactions (KEA)

RankGene SetZ-score
1* TXK3.87783514
2* MAP4K13.80737069
3MAP3K143.30751784
4JAK33.27973291
5BLK2.93491445
6IRAK42.76711893
7IKBKE2.75813297
8TYK22.75159441
9KIT2.56862660
10TBK12.54413427
11PRPF4B2.50106432
12* ZAP702.44507478
13ITK2.42721688
14TEC2.35296065
15IKBKB2.06435606
16BTK2.05640841
17STK101.93413814
18IRAK31.90874570
19JAK11.86523963
20CSK1.81872465
21* LCK1.77486558
22PIM21.68069668
23RIPK41.67340987
24FGFR41.67095925
25* SYK1.63211306
26CSF1R1.52992086
27* HCK1.49960432
28TGFBR21.48984045
29CHUK1.44238566
30NME21.41037059
31PIM11.38810279
32TAOK31.37587835
33FGFR31.32642904
34MAP2K31.32341156
35MAP3K131.27447059
36RPS6KA41.25219139
37FES1.24919302
38NLK1.21528283
39* LYN1.21157906
40CLK11.20599414
41MAP3K11.15005545
42FLT31.13685639
43NEK91.13239986
44EPHB11.05948764
45GRK61.02738536
46MST41.01246550
47JAK20.99817713
48ERN10.95925965
49IRAK20.94472249
50EEF2K0.93602577
51KDR0.91983226
52MARK30.89507644
53SIK30.85613136
54CAMKK20.84209690
55CDC42BPA0.79819879
56MAP3K110.79434048
57PRKCQ0.78767565
58LRRK20.70209677
59SIK20.69846652
60PIK3CG0.69200644
61EPHA30.67893880
62MARK20.67039344
63TGFBR10.66014431
64ADRBK20.64492788
65MAPK70.63796084
66CDK120.62858939
67MAP3K120.62726202
68STK40.62341402
69KSR20.59682174
70MAPK120.59600319
71TNK20.58736518
72CAMKK10.58574558
73MAP3K100.58324933
74IRAK10.56354751
75RIPK10.55636347
76CDK60.52118113
77MOS0.51883478
78TAOK10.51641530
79YES10.51384132
80MAP2K60.51338768
81CDK40.50204946
82MATK0.44929225
83PDPK10.44894082
84RPS6KA60.44535498
85PRKCH0.44209530
86PKN20.42532678
87EIF2AK20.42500861
88MAPKAPK20.41506748
89ABL10.41339464
90TRPM70.41295946
91RPS6KA50.40800064
92PDGFRB0.40754160
93TYRO30.40584078
94EGFR0.39774378
95MAP3K30.38665754
96TAOK20.38450433
97PDK10.37816658
98PRKCD0.37465614
99MAPK40.36049191
100HIPK20.35564042
101TSSK60.35476747
102PTK60.35210789
103PRKD20.34997826
104FGR0.34419284
105GRK70.33992396
106MAP3K60.33700462
107ATR0.32785629
108FYN0.31937587
109SGK30.31681866
110MAP3K70.31328516
111MAPK110.30804203
112MAP3K50.30438627
113ACVR1B0.28983799
114BRD40.28789264
115RPS6KL10.28344873
116RPS6KC10.28344873
117BMPR20.28013404
118MAPK30.27057977
119TESK20.26341799
120DAPK20.24461548
121DYRK1B0.24072387
122MAP3K80.24045127
123ALK0.23912839
124TRIB30.23531024

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.41469577
2Allograft rejection_Homo sapiens_hsa053303.19993567
3Graft-versus-host disease_Homo sapiens_hsa053323.11235758
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.07879291
5Leishmaniasis_Homo sapiens_hsa051402.93681934
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.82471647
7Measles_Homo sapiens_hsa051622.62390021
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.53238647
9Asthma_Homo sapiens_hsa053102.42121534
10* T cell receptor signaling pathway_Homo sapiens_hsa046602.30445586
11Hematopoietic cell lineage_Homo sapiens_hsa046402.26353883
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.15571600
13* Osteoclast differentiation_Homo sapiens_hsa043802.14293568
14Staphylococcus aureus infection_Homo sapiens_hsa051502.13347758
15* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.10296452
16Toll-like receptor signaling pathway_Homo sapiens_hsa046202.02773979
17Autoimmune thyroid disease_Homo sapiens_hsa053202.00302323
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.98954285
19Antigen processing and presentation_Homo sapiens_hsa046121.97037748
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.92813851
21Legionellosis_Homo sapiens_hsa051341.86056451
22Type I diabetes mellitus_Homo sapiens_hsa049401.82446490
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.77682791
24B cell receptor signaling pathway_Homo sapiens_hsa046621.73212027
25Herpes simplex infection_Homo sapiens_hsa051681.72944947
26Malaria_Homo sapiens_hsa051441.66263778
27Pertussis_Homo sapiens_hsa051331.63804253
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.56454847
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.53797408
30Influenza A_Homo sapiens_hsa051641.53289565
31TNF signaling pathway_Homo sapiens_hsa046681.51614440
32Toxoplasmosis_Homo sapiens_hsa051451.51535081
33Tuberculosis_Homo sapiens_hsa051521.51264619
34Rheumatoid arthritis_Homo sapiens_hsa053231.32830971
35Chemokine signaling pathway_Homo sapiens_hsa040621.30855689
36Viral myocarditis_Homo sapiens_hsa054161.29150775
37Hepatitis B_Homo sapiens_hsa051611.27351380
38Acute myeloid leukemia_Homo sapiens_hsa052211.22602644
39Shigellosis_Homo sapiens_hsa051311.22024341
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.21741262
41* Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.19087697
42Salmonella infection_Homo sapiens_hsa051321.18484131
43Apoptosis_Homo sapiens_hsa042101.17530422
44Other glycan degradation_Homo sapiens_hsa005111.04165357
45Leukocyte transendothelial migration_Homo sapiens_hsa046700.98322165
46African trypanosomiasis_Homo sapiens_hsa051430.94800358
47Chronic myeloid leukemia_Homo sapiens_hsa052200.89449858
48Hepatitis C_Homo sapiens_hsa051600.87862172
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86986877
50Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86395002
51Epstein-Barr virus infection_Homo sapiens_hsa051690.85681035
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80289203
53HTLV-I infection_Homo sapiens_hsa051660.77219415
54Pancreatic cancer_Homo sapiens_hsa052120.76173686
55* Platelet activation_Homo sapiens_hsa046110.75090849
56Lysosome_Homo sapiens_hsa041420.74918451
57Prolactin signaling pathway_Homo sapiens_hsa049170.69939239
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.69040450
59DNA replication_Homo sapiens_hsa030300.67568777
60Viral carcinogenesis_Homo sapiens_hsa052030.67122586
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65777200
62Base excision repair_Homo sapiens_hsa034100.60949148
63Phagosome_Homo sapiens_hsa041450.57847962
64Non-homologous end-joining_Homo sapiens_hsa034500.56743707
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56003884
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.55865936
67Renal cell carcinoma_Homo sapiens_hsa052110.53389739
68Dorso-ventral axis formation_Homo sapiens_hsa043200.51527502
69Small cell lung cancer_Homo sapiens_hsa052220.48652276
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47436306
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47079166
72Notch signaling pathway_Homo sapiens_hsa043300.45284213
73Ribosome_Homo sapiens_hsa030100.43998828
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43761304
75p53 signaling pathway_Homo sapiens_hsa041150.43737657
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.43276706
77Amoebiasis_Homo sapiens_hsa051460.42292853
78Type II diabetes mellitus_Homo sapiens_hsa049300.41669998
79Colorectal cancer_Homo sapiens_hsa052100.41071283
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37578215
81HIF-1 signaling pathway_Homo sapiens_hsa040660.36716941
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.36400432
83VEGF signaling pathway_Homo sapiens_hsa043700.36329102
84Mismatch repair_Homo sapiens_hsa034300.35029317
85Homologous recombination_Homo sapiens_hsa034400.34971293
86GnRH signaling pathway_Homo sapiens_hsa049120.34583766
87mTOR signaling pathway_Homo sapiens_hsa041500.34494800
88Choline metabolism in cancer_Homo sapiens_hsa052310.34227958
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33033973
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32492088
91Spliceosome_Homo sapiens_hsa030400.32371944
92Prion diseases_Homo sapiens_hsa050200.32026958
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.29065346
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.28580339
95Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.27455257
96Non-small cell lung cancer_Homo sapiens_hsa052230.27317310
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.26859043
98RNA degradation_Homo sapiens_hsa030180.26298313
99Prostate cancer_Homo sapiens_hsa052150.26104030
100Endometrial cancer_Homo sapiens_hsa052130.25369972
101Caffeine metabolism_Homo sapiens_hsa002320.25335955
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25240514
103Endocytosis_Homo sapiens_hsa041440.24573823
104Inositol phosphate metabolism_Homo sapiens_hsa005620.24019658
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23996137
106Systemic lupus erythematosus_Homo sapiens_hsa053220.23410493
107FoxO signaling pathway_Homo sapiens_hsa040680.23025137
108MAPK signaling pathway_Homo sapiens_hsa040100.22371776
109Complement and coagulation cascades_Homo sapiens_hsa046100.22123667
110Fanconi anemia pathway_Homo sapiens_hsa034600.21773088
111Bladder cancer_Homo sapiens_hsa052190.21575739
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.19509994
113MicroRNAs in cancer_Homo sapiens_hsa052060.19409764
114ErbB signaling pathway_Homo sapiens_hsa040120.18479089
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.17101505
116Insulin resistance_Homo sapiens_hsa049310.14912912
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.14632821
118Thyroid cancer_Homo sapiens_hsa052160.14177082

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »