LCT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the glycosyl hydrolase 1 family of proteins. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme is integral to the plasma membrane and has both phlorizin hydrolase activity and lactase activity. Mutations in this gene are associated with congenital lactase deficiency. Polymorphisms in this gene are associated with lactase persistence, in which intestinal lactase activity persists at childhood levels into adulthood. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)8.44452533
2vitamin A metabolic process (GO:0006776)8.25504341
3triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.68622448
4hormone catabolic process (GO:0042447)6.55606737
5phospholipid efflux (GO:0033700)6.38988729
6virion attachment to host cell (GO:0019062)6.21821020
7adhesion of symbiont to host cell (GO:0044650)6.21821020
8actin filament depolymerization (GO:0030042)6.09846788
9regulation of cholesterol esterification (GO:0010872)6.06949756
10positive regulation of triglyceride lipase activity (GO:0061365)6.06309100
11positive regulation of lipoprotein lipase activity (GO:0051006)6.06309100
12flavonoid metabolic process (GO:0009812)6.04414864
13plasma lipoprotein particle assembly (GO:0034377)5.90086909
14regulation of triglyceride catabolic process (GO:0010896)5.88731886
15protein-lipid complex assembly (GO:0065005)5.64375316
16drug catabolic process (GO:0042737)5.60109264
17bile acid and bile salt transport (GO:0015721)5.55805079
18cholesterol efflux (GO:0033344)5.50590202
19peptide hormone processing (GO:0016486)5.29037770
20digestive system process (GO:0022600)5.28920145
21very-low-density lipoprotein particle assembly (GO:0034379)5.18232691
22lipoprotein metabolic process (GO:0042157)5.16152803
23peptide catabolic process (GO:0043171)5.15244218
24regulation of guanylate cyclase activity (GO:0031282)5.11019288
25lipoprotein transport (GO:0042953)5.07570566
26oligosaccharide catabolic process (GO:0009313)5.05114867
27adhesion of symbiont to host (GO:0044406)5.03811681
28glucose 6-phosphate metabolic process (GO:0051156)5.02790320
29negative regulation of lipase activity (GO:0060192)4.87515240
30modified amino acid transport (GO:0072337)4.70119374
31epoxygenase P450 pathway (GO:0019373)4.64780875
32cellular glucuronidation (GO:0052695)4.55695916
33positive regulation of guanylate cyclase activity (GO:0031284)4.54468299
34glucuronate metabolic process (GO:0019585)4.53679322
35uronic acid metabolic process (GO:0006063)4.53679322
36fat-soluble vitamin biosynthetic process (GO:0042362)4.52107117
37regulation of bile acid biosynthetic process (GO:0070857)4.49818767
38reverse cholesterol transport (GO:0043691)4.48698427
39regulation of triglyceride metabolic process (GO:0090207)4.46669990
40purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.46053769
413-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.46053769
42response to hepatocyte growth factor (GO:0035728)4.41546308
43cellular response to hepatocyte growth factor stimulus (GO:0035729)4.41546308
44positive regulation of fatty acid biosynthetic process (GO:0045723)4.39080524
45glutamine family amino acid biosynthetic process (GO:0009084)4.35626298
46plasma lipoprotein particle clearance (GO:0034381)4.35106300
47sterol transport (GO:0015918)4.34225787
48cholesterol transport (GO:0030301)4.34225787
49cholesterol homeostasis (GO:0042632)4.32894882
50drinking behavior (GO:0042756)4.32514722
51negative regulation of sterol transport (GO:0032372)4.28721342
52negative regulation of cholesterol transport (GO:0032375)4.28721342
53diacylglycerol metabolic process (GO:0046339)4.28312282
54negative regulation of fatty acid biosynthetic process (GO:0045717)4.27298907
55sterol homeostasis (GO:0055092)4.27101010
56vitamin D metabolic process (GO:0042359)4.22444995
57nucleobase catabolic process (GO:0046113)4.15986292
58heme transport (GO:0015886)4.13165486
59sphingomyelin metabolic process (GO:0006684)4.11455146
60fat-soluble vitamin metabolic process (GO:0006775)4.08417212
61positive regulation of glycoprotein biosynthetic process (GO:0010560)4.07471767
62* digestion (GO:0007586)4.02878265
63homocysteine metabolic process (GO:0050667)4.02086666
64high-density lipoprotein particle remodeling (GO:0034375)3.95510416
65L-ascorbic acid metabolic process (GO:0019852)3.85155824
66plasma lipoprotein particle remodeling (GO:0034369)3.82477066
67protein-lipid complex remodeling (GO:0034368)3.82477066
68macromolecular complex remodeling (GO:0034367)3.82477066
69regulation of protein glycosylation (GO:0060049)3.82361678
70cellular carbohydrate catabolic process (GO:0044275)3.76150695
71regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.75907508
72endocrine process (GO:0050886)3.75907508
73regulation of systemic arterial blood pressure by hormone (GO:0001990)3.75907508
74L-alpha-amino acid transmembrane transport (GO:1902475)3.75870456
75acylglycerol homeostasis (GO:0055090)3.68888593
76triglyceride homeostasis (GO:0070328)3.68888593
77phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.68013007
78cellular response to oxygen radical (GO:0071450)3.66514236
79removal of superoxide radicals (GO:0019430)3.66514236
80cellular response to superoxide (GO:0071451)3.66514236
81plasma lipoprotein particle organization (GO:0071827)3.63880568
82protein-lipid complex subunit organization (GO:0071825)3.63545214
83sulfate transmembrane transport (GO:1902358)3.62425155
84cellular response to nitric oxide (GO:0071732)3.61055754
85regulation of lipoprotein metabolic process (GO:0050746)3.60268453
86bile acid metabolic process (GO:0008206)3.53080780
87phenylpropanoid metabolic process (GO:0009698)3.52565597
88positive regulation of glycoprotein metabolic process (GO:1903020)3.52083555
89positive regulation of triglyceride metabolic process (GO:0090208)3.50724113
90cellular response to zinc ion (GO:0071294)3.49692305
91NADH metabolic process (GO:0006734)3.49206227
92positive regulation of lipid catabolic process (GO:0050996)3.41835441
93bundle of His cell to Purkinje myocyte communication (GO:0086069)3.41016837
94fructose metabolic process (GO:0006000)3.40163311
95negative regulation of digestive system process (GO:0060457)3.39973141
96response to hydroperoxide (GO:0033194)3.38864774
97regulation of systemic arterial blood pressure (GO:0003073)3.38196000
98positive regulation of p38MAPK cascade (GO:1900745)3.37516175
99retinoid metabolic process (GO:0001523)3.33259956
100purine nucleotide salvage (GO:0032261)3.31628701
101regulation of digestive system process (GO:0044058)3.29807037
102regulation of cytokine secretion involved in immune response (GO:0002739)3.28850323
103regulation of lipoprotein particle clearance (GO:0010984)3.22780390
104protein kinase C signaling (GO:0070528)3.18672176
105regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.17552175
106alkaloid metabolic process (GO:0009820)3.16488316
107bicarbonate transport (GO:0015701)3.15838693
108ovulation from ovarian follicle (GO:0001542)3.15469460
109sulfur compound transport (GO:0072348)3.15086704
110polyol transport (GO:0015791)3.14386132
111response to phenylpropanoid (GO:0080184)3.14294374
112regulation of actin nucleation (GO:0051125)3.13818669
113cellular response to reactive nitrogen species (GO:1902170)3.12663241
114diterpenoid metabolic process (GO:0016101)3.11282235
115transepithelial transport (GO:0070633)3.11174218
116regulation of lipid catabolic process (GO:0050994)3.11113595
117regulation of cholesterol transport (GO:0032374)3.10546998
118regulation of sterol transport (GO:0032371)3.10546998
119cGMP biosynthetic process (GO:0006182)3.10470288
120drug transport (GO:0015893)3.07118320
121nucleoside diphosphate biosynthetic process (GO:0009133)3.06811707
122regulation of cholesterol homeostasis (GO:2000188)3.05332750
123negative regulation of sodium ion transport (GO:0010766)3.04542597
124regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.98882112
125sulfate transport (GO:0008272)2.97705698
126regulation of Golgi to plasma membrane protein transport (GO:0042996)2.96957269
127omega-hydroxylase P450 pathway (GO:0097267)2.95076337
128lipid homeostasis (GO:0055088)2.94765674
129cellular anion homeostasis (GO:0030002)2.89717841
130drug metabolic process (GO:0017144)2.87396277
131sulfation (GO:0051923)2.85556023
132mature B cell differentiation involved in immune response (GO:0002313)2.85390218
133exogenous drug catabolic process (GO:0042738)2.83639336
134maintenance of gastrointestinal epithelium (GO:0030277)2.83020358
135negative regulation of T cell receptor signaling pathway (GO:0050860)2.82626711
136glycerol metabolic process (GO:0006071)2.81651472
137angiotensin maturation (GO:0002003)13.2883622
138intestinal cholesterol absorption (GO:0030299)12.7798195
139intestinal absorption (GO:0050892)12.4859071

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.32703173
2CDX2_20551321_ChIP-Seq_CACO-2_Human5.12801817
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.18707552
4SOX2_27498859_Chip-Seq_STOMACH_Mouse3.09989924
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.77712857
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.61070230
7GATA4_25053715_ChIP-Seq_YYC3_Human2.48907465
8HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.47568326
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.47131960
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.41447620
11GATA6_25053715_ChIP-Seq_YYC3_Human2.18792796
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.17690799
13RXR_22158963_ChIP-Seq_LIVER_Mouse2.16125562
14CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.13689397
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.11547814
16SOX2_20726797_ChIP-Seq_SW620_Human1.99289537
17PPAR_26484153_Chip-Seq_NCI-H1993_Human1.93598964
18CDX2_19796622_ChIP-Seq_MESCs_Mouse1.88476928
19CDX2_22108803_ChIP-Seq_LS180_Human1.85640950
20SRY_22984422_ChIP-ChIP_TESTIS_Rat1.84052900
21NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.81634490
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.78627077
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.76818714
24TRIM28_21343339_ChIP-Seq_HEK293_Human1.72247557
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.68201098
26KLF5_25053715_ChIP-Seq_YYC3_Human1.68110456
27TCF4_18268006_ChIP-ChIP_LS174T_Human1.65934767
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.65664769
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65612976
30DROSHA_22980978_ChIP-Seq_HELA_Human1.64934221
31FOXA1_25552417_ChIP-Seq_VCAP_Human1.55750077
32RUNX1_27514584_Chip-Seq_MCF-7_Human1.54918374
33GATA1_22025678_ChIP-Seq_K562_Human1.51394345
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.49067456
35CEBPB_22108803_ChIP-Seq_LS180_Human1.43850282
36NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.43783083
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43578201
38GATA2_19941826_ChIP-Seq_K562_Human1.42879432
39EGR1_23403033_ChIP-Seq_LIVER_Mouse1.42089201
40NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40790410
41GATA1_26923725_Chip-Seq_HPCs_Mouse1.38516006
42* NANOG_20526341_ChIP-Seq_ESCs_Human1.35719276
43RXR_22108803_ChIP-Seq_LS180_Human1.35366623
44ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35300972
45HNF4A_19822575_ChIP-Seq_HepG2_Human1.34680489
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33543021
47BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.33504398
48FOXA2_19822575_ChIP-Seq_HepG2_Human1.31798558
49KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30400813
50FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.30013604
51CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.29294159
52BCAT_22108803_ChIP-Seq_LS180_Human1.27520876
53SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.26302493
54CTNNB1_20460455_ChIP-Seq_HCT116_Human1.23928767
55SMAD3_21741376_ChIP-Seq_HESCs_Human1.22857186
56PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.22728527
57KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22175917
58CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.21393855
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19897410
60FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18223379
61FOXA1_25329375_ChIP-Seq_VCAP_Human1.18223379
62FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.17846526
63RACK7_27058665_Chip-Seq_MCF-7_Human1.17833166
64VDR_22108803_ChIP-Seq_LS180_Human1.15640112
65CTCF_27219007_Chip-Seq_Bcells_Human1.15152959
66FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14604175
67FOXO3_23340844_ChIP-Seq_DLD1_Human1.14528317
68ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12819567
69THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11000693
70KAP1_22055183_ChIP-Seq_ESCs_Mouse1.10245044
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09807867
72CBP_21632823_ChIP-Seq_H3396_Human1.08666220
73EGR1_19032775_ChIP-ChIP_M12_Human1.08351467
74ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08196260
75FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.08170335
76CREB1_26743006_Chip-Seq_LNCaP_Human1.07728260
77ATF3_27146783_Chip-Seq_COLON_Human1.07690714
78NCOR_22424771_ChIP-Seq_293T_Human1.07130300
79CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06857169
80ESR1_21235772_ChIP-Seq_MCF-7_Human1.06612701
81STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05866324
82ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.05599508
83PRDM14_20953172_ChIP-Seq_ESCs_Human1.05021052
84PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.04725209
85PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.04651276
86TP53_18474530_ChIP-ChIP_U2OS_Human1.02841250
87EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02382896
88TCF4_22108803_ChIP-Seq_LS180_Human1.02068189
89FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.00944184
90AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00882670
91FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00145718
92ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98583996
93JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.98039430
94VDR_24787735_ChIP-Seq_THP-1_Human0.97312125
95AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.96897936
96SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.96234682
97ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95658436
98GATA1_19941826_ChIP-Seq_K562_Human0.95295806
99HNFA_21074721_ChIP-Seq_CACO-2_Human0.94464270
100TP53_16413492_ChIP-PET_HCT116_Human0.94166519
101TAF2_19829295_ChIP-Seq_ESCs_Human0.94137518
102LXR_22292898_ChIP-Seq_THP-1_Human0.92769396
103WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91461154
104TP63_23658742_ChIP-Seq_EP156T_Human0.90738304
105* SOX2_22085726_ChIP-Seq_NPCs_Mouse0.89274507
106ETV1_20927104_ChIP-Seq_GIST48_Human0.89055550
107PHF8_20622853_ChIP-Seq_HELA_Human0.88786335
108HIF1A_21447827_ChIP-Seq_MCF-7_Human0.88147598
109CLOCK_20551151_ChIP-Seq_293T_Human0.87097785
110SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87009871
111EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.86927149
112JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86311110
113VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.85247152
114CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.84790104
115KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.84771235
116UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84705841
117GATA1_19941827_ChIP-Seq_MEL_Mouse0.83764785
118GATA3_21878914_ChIP-Seq_MCF-7_Human0.82036748
119RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.81098376
120MYC_19829295_ChIP-Seq_ESCs_Human0.80277271
121GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.80218832
122VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.79953749
123SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.79569708
124SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.79440359
125SPI1_23127762_ChIP-Seq_K562_Human0.78271283
126NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.78269190
127PIAS1_25552417_ChIP-Seq_VCAP_Human0.76880450
128CBP_20019798_ChIP-Seq_JUKART_Human0.76672975
129IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.76672975
130RBPJ_21746931_ChIP-Seq_IB4_Human0.75663099
131NFYA_21822215_ChIP-Seq_K562_Human0.75193218
132KLF5_20875108_ChIP-Seq_MESCs_Mouse0.74881729
133DNAJC2_21179169_ChIP-ChIP_NT2_Human0.74705039
134SOX2_19829295_ChIP-Seq_ESCs_Human0.74571726
135NANOG_19829295_ChIP-Seq_ESCs_Human0.74571726
136IRF8_21731497_ChIP-ChIP_J774_Mouse0.74413331
137SALL4_18804426_ChIP-ChIP_XEN_Mouse0.74231675
138FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.73387415
139PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.72594355
140MTF2_20144788_ChIP-Seq_MESCs_Mouse0.72448490
141P300_27058665_Chip-Seq_ZR-75-30cells_Human0.72004146
142ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.71423846
143SUZ12_27294783_Chip-Seq_ESCs_Mouse0.70952214
144KDM2B_26808549_Chip-Seq_K562_Human0.70296222
145AHR_22903824_ChIP-Seq_MCF-7_Human0.69710168
146GATA2_21666600_ChIP-Seq_HMVEC_Human0.69544740
147NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.68735221
148STAT1_17558387_ChIP-Seq_HELA_Human0.68712086
149SMAD4_21741376_ChIP-Seq_HESCs_Human0.68451444
150TP63_22573176_ChIP-Seq_HFKS_Human0.68384070
151STAT6_21828071_ChIP-Seq_BEAS2B_Human0.68174885
152TCF3_18692474_ChIP-Seq_MEFs_Mouse0.68054242
153JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.67821027
154NR3C1_23031785_ChIP-Seq_PC12_Mouse0.66762689

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis9.70361213
2MP0001666_abnormal_nutrient_absorption6.88127572
3MP0009840_abnormal_foam_cell4.97364720
4MP0003183_abnormal_peptide_metabolism4.46623391
5MP0002139_abnormal_hepatobiliary_system4.02863396
6MP0008875_abnormal_xenobiotic_pharmacok3.82127980
7MP0003252_abnormal_bile_duct3.30515778
8MP0010234_abnormal_vibrissa_follicle3.16867111
9MP0005085_abnormal_gallbladder_physiolo3.02737521
10MP0010329_abnormal_lipoprotein_level3.00795058
11MP0004264_abnormal_extraembryonic_tissu2.87743352
12MP0000462_abnormal_digestive_system2.72531136
13MP0002822_catalepsy2.71445291
14MP0003866_abnormal_defecation2.47488283
15MP0004019_abnormal_vitamin_homeostasis2.19971295
16MP0005084_abnormal_gallbladder_morpholo2.14776061
17MP0004043_abnormal_pH_regulation2.13715586
18MP0004147_increased_porphyrin_level1.96960358
19MP0002876_abnormal_thyroid_physiology1.84649395
20MP0005448_abnormal_energy_balance1.69337907
21MP0004270_analgesia1.67462598
22MP0005377_hearing/vestibular/ear_phenot1.66880025
23MP0003878_abnormal_ear_physiology1.66880025
24MP0001664_abnormal_digestion1.63515867
25MP0002254_reproductive_system_inflammat1.54946471
26MP0009780_abnormal_chondrocyte_physiolo1.49486898
27MP0005409_darkened_coat_color1.49084490
28MP0002089_abnormal_postnatal_growth/wei1.48661991
29MP0005381_digestive/alimentary_phenotyp1.45238067
30MP0005365_abnormal_bile_salt1.41390936
31MP0000537_abnormal_urethra_morphology1.36772246
32MP0001663_abnormal_digestive_system1.35726066
33MP0003705_abnormal_hypodermis_morpholog1.34269784
34MP0009697_abnormal_copulation1.30097599
35MP0000538_abnormal_urinary_bladder1.29853828
36MP0003191_abnormal_cellular_cholesterol1.29678015
37MP0002796_impaired_skin_barrier1.27846537
38MP0003868_abnormal_feces_composition1.27651647
39MP0005670_abnormal_white_adipose1.23467777
40MP0010352_gastrointestinal_tract_polyps1.22941516
41MP0003300_gastrointestinal_ulcer1.20404154
42MP0000477_abnormal_intestine_morphology1.19433491
43MP0002118_abnormal_lipid_homeostasis1.15836517
44MP0004859_abnormal_synaptic_plasticity1.15552230
45MP0001873_stomach_inflammation1.14666507
46MP0002396_abnormal_hematopoietic_system1.13408048
47MP0005332_abnormal_amino_acid1.10137681
48MP0010155_abnormal_intestine_physiology1.08384056
49MP0001986_abnormal_taste_sensitivity1.05853996
50MP0009053_abnormal_anal_canal0.93944762
51MP0008872_abnormal_physiological_respon0.91515175
52MP0000609_abnormal_liver_physiology0.91337950
53MP0009765_abnormal_xenobiotic_induced0.91019300
54MP0001764_abnormal_homeostasis0.89998217
55MP0006054_spinal_hemorrhage0.89409293
56MP0005535_abnormal_body_temperature0.89355917
57MP0003283_abnormal_digestive_organ0.89003807
58MP0000467_abnormal_esophagus_morphology0.87875681
59MP0003879_abnormal_hair_cell0.85118305
60MP0005166_decreased_susceptibility_to0.84654315
61MP0009643_abnormal_urine_homeostasis0.84452791
62MP0000490_abnormal_crypts_of0.84355780
63MP0000604_amyloidosis0.83575887
64MP0004947_skin_inflammation0.83462093
65MP0009379_abnormal_foot_pigmentation0.83319764
66MP0003718_maternal_effect0.82101916
67MP0001849_ear_inflammation0.82024498
68MP0001188_hyperpigmentation0.81436057
69MP0005167_abnormal_blood-brain_barrier0.79798096
70MP0005266_abnormal_metabolism0.77495555
71MP0010678_abnormal_skin_adnexa0.74604939
72MP0001765_abnormal_ion_homeostasis0.73042566
73MP0001756_abnormal_urination0.72400118
74MP0000249_abnormal_blood_vessel0.72250512
75MP0001485_abnormal_pinna_reflex0.71353284
76MP0009384_cardiac_valve_regurgitation0.69957058
77MP0002138_abnormal_hepatobiliary_system0.68984176
78MP0005319_abnormal_enzyme/_coenzyme0.68897383
79MP0000678_abnormal_parathyroid_gland0.68689365
80MP0003638_abnormal_response/metabolism_0.67953564
81MP0005501_abnormal_skin_physiology0.64088343
82MP0003953_abnormal_hormone_level0.60974640
83MP0005376_homeostasis/metabolism_phenot0.60116436
84MP0002098_abnormal_vibrissa_morphology0.59944834
85MP0003806_abnormal_nucleotide_metabolis0.59527771
86MP0005395_other_phenotype0.59380873
87MP0006138_congestive_heart_failure0.59352418
88MP0000516_abnormal_urinary_system0.59166002
89MP0005367_renal/urinary_system_phenotyp0.59166002
90MP0005584_abnormal_enzyme/coenzyme_acti0.56630635
91MP0008469_abnormal_protein_level0.53068505
92MP0005551_abnormal_eye_electrophysiolog0.52309812
93MP0002136_abnormal_kidney_physiology0.51892623
94MP0009642_abnormal_blood_homeostasis0.51523276
95MP0003950_abnormal_plasma_membrane0.51162626
96MP0000230_abnormal_systemic_arterial0.51068939
97MP0009764_decreased_sensitivity_to0.49934559
98MP0009115_abnormal_fat_cell0.49923778
99MP0006082_CNS_inflammation0.49181537
100MP0005636_abnormal_mineral_homeostasis0.48389493
101MP0004145_abnormal_muscle_electrophysio0.48299520
102MP0003329_amyloid_beta_deposits0.47492954
103MP0000427_abnormal_hair_cycle0.47252419
104MP0001440_abnormal_grooming_behavior0.47152958
105MP0001881_abnormal_mammary_gland0.45276923
106MP0002078_abnormal_glucose_homeostasis0.44292070
107MP0001919_abnormal_reproductive_system0.43150572
108MP0001191_abnormal_skin_condition0.42396836
109MP0005451_abnormal_body_composition0.41662600
110MP0005058_abnormal_lysosome_morphology0.41399139
111MP0003136_yellow_coat_color0.41385196
112MP0005174_abnormal_tail_pigmentation0.41223482
113MP0003119_abnormal_digestive_system0.40849156
114MP0005334_abnormal_fat_pad0.40420122
115MP0000579_abnormal_nail_morphology0.40112892
116MP0003385_abnormal_body_wall0.39937284
117MP0001501_abnormal_sleep_pattern0.39679601
118MP0008961_abnormal_basal_metabolism0.39505242
119MP0002971_abnormal_brown_adipose0.38880618
120MP0001216_abnormal_epidermal_layer0.38548993
121MP0001845_abnormal_inflammatory_respons0.37598266
122MP0000598_abnormal_liver_morphology0.36490222
123MP0002069_abnormal_eating/drinking_beha0.36331206
124MP0004885_abnormal_endolymph0.36264442
125MP0002734_abnormal_mechanical_nocicepti0.35822000
126MP0000534_abnormal_ureter_morphology0.34148679
127MP0002135_abnormal_kidney_morphology0.31437099
128MP0000566_synostosis0.31185750
129MP0002638_abnormal_pupillary_reflex0.30763537
130MP0002909_abnormal_adrenal_gland0.29004501
131MP0005464_abnormal_platelet_physiology0.26984140
132MP0005410_abnormal_fertilization0.25405185
133MP0005389_reproductive_system_phenotype0.24540122
134MP0004142_abnormal_muscle_tone0.24394892
135MP0002557_abnormal_social/conspecific_i0.24239317

Predicted human phenotypes

RankGene SetZ-score
1Acanthocytosis (HP:0001927)8.84093274
2Hypobetalipoproteinemia (HP:0003563)8.81931793
3Ileus (HP:0002595)8.26265462
4Abnormality of glutamine family amino acid metabolism (HP:0010902)6.63997524
5Malnutrition (HP:0004395)6.40168862
6Autoimmune thrombocytopenia (HP:0001973)6.07815215
7Conjugated hyperbilirubinemia (HP:0002908)5.97852361
8Hyperlipoproteinemia (HP:0010980)5.72194284
9Widely patent fontanelles and sutures (HP:0004492)5.71326101
10Abnormality of proline metabolism (HP:0010907)5.66823984
11Hydroxyprolinuria (HP:0003080)5.66823984
12Facial shape deformation (HP:0011334)5.26543779
13Potter facies (HP:0002009)5.26543779
14Pigmentary retinal degeneration (HP:0001146)5.11554523
15Poikilocytosis (HP:0004447)5.07721428
16Hypolipoproteinemia (HP:0010981)4.97728042
17Fat malabsorption (HP:0002630)4.51261682
18Autoimmune hemolytic anemia (HP:0001890)4.42210485
19Cupped ribs (HP:0000887)4.41103838
20Right ventricular cardiomyopathy (HP:0011663)4.28802604
21Increased IgE level (HP:0003212)3.97150747
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.83541916
23Decreased circulating renin level (HP:0003351)3.77754684
24Xanthomatosis (HP:0000991)3.68332359
25Wide cranial sutures (HP:0010537)3.64730373
26Abnormality of pyrimidine metabolism (HP:0004353)3.61411049
27Proximal tubulopathy (HP:0000114)3.56916447
28Steatorrhea (HP:0002570)3.48992545
29Hyperglycinuria (HP:0003108)3.36766510
30Hypercholesterolemia (HP:0003124)3.26661791
31Abnormality of magnesium homeostasis (HP:0004921)3.26522048
32Mesangial abnormality (HP:0001966)3.20880459
33Hyperammonemia (HP:0001987)3.19505830
34Chronic diarrhea (HP:0002028)3.14352664
35Abdominal distention (HP:0003270)3.12849458
36Epidermoid cyst (HP:0200040)3.10734011
37Abnormality of the vitamin B12 metabolism (HP:0004341)3.02935329
38Hypomagnesemia (HP:0002917)3.01191118
39Gastrointestinal dysmotility (HP:0002579)2.99110985
40Increased mean platelet volume (HP:0011877)2.97503442
41Vacuolated lymphocytes (HP:0001922)2.94397760
42Reticulocytosis (HP:0001923)2.93575196
43Abnormality of B cell number (HP:0010975)2.88105485
44B lymphocytopenia (HP:0010976)2.88105485
45Alkalosis (HP:0001948)2.85969531
46Hypoproteinemia (HP:0003075)2.85393097
47Abnormality of vitamin B metabolism (HP:0004340)2.81877921
48Tetany (HP:0001281)2.79996207
49Glycosuria (HP:0003076)2.79394625
50Abnormality of urine glucose concentration (HP:0011016)2.79394625
51Progressive sensorineural hearing impairment (HP:0000408)2.78249041
52Nephrolithiasis (HP:0000787)2.77226796
53Severe combined immunodeficiency (HP:0004430)2.75606944
54Abnormality of purine metabolism (HP:0004352)2.73923921
55Mildly elevated creatine phosphokinase (HP:0008180)2.71328161
56Abnormal glucose tolerance (HP:0001952)2.70670401
57Intrahepatic cholestasis (HP:0001406)2.67333848
58Abnormal platelet volume (HP:0011876)2.64591351
59Abnormality of the common coagulation pathway (HP:0010990)2.63230968
60Confusion (HP:0001289)2.54846441
61Abnormality of monocarboxylic acid metabolism (HP:0010996)2.51781162
62Abnormality of macrophages (HP:0004311)2.49746068
63Thyroiditis (HP:0100646)2.48779664
64Hyperglycinemia (HP:0002154)2.48693435
65Polycythemia (HP:0001901)2.48168796
66Abnormality of renin-angiotensin system (HP:0000847)2.43558669
67Combined immunodeficiency (HP:0005387)2.40709112
68Progressive hearing impairment (HP:0001730)2.40434596
69Abnormality of vitamin metabolism (HP:0100508)2.37227457
70Posterior subcapsular cataract (HP:0007787)2.36016799
71Spontaneous abortion (HP:0005268)2.33572631
72Abnormality of the gastric mucosa (HP:0004295)2.27755884
73Abnormality of serine family amino acid metabolism (HP:0010894)2.25197695
74Abnormality of glycine metabolism (HP:0010895)2.25197695
75Metabolic alkalosis (HP:0200114)2.18727782
76Abnormality of nucleobase metabolism (HP:0010932)2.16494554
77Enlarged epiphyses (HP:0010580)2.15395668
78Hyperuricemia (HP:0002149)2.12736564
79Increased purine levels (HP:0004368)2.12736564
80Megaloblastic anemia (HP:0001889)2.11302330
81Hyperphosphaturia (HP:0003109)2.08589962
82Abnormality of small intestinal villus morphology (HP:0011472)2.07442678
83Villous atrophy (HP:0011473)2.07442678
84Abnormal platelet function (HP:0011869)2.05049827
85Impaired platelet aggregation (HP:0003540)2.05049827
86White forelock (HP:0002211)2.04132632
87Gingival bleeding (HP:0000225)2.03144891
88Subcapsular cataract (HP:0000523)2.01516603
89* Dehydration (HP:0001944)1.99110431
90Delayed CNS myelination (HP:0002188)1.98758239
91Hyperaldosteronism (HP:0000859)1.97820041
92Symptomatic seizures (HP:0011145)1.96710866
93Hypotension (HP:0002615)1.96315542
94Hyperkalemia (HP:0002153)1.95679058
95Syncope (HP:0001279)1.95523195
96Patchy hypopigmentation of hair (HP:0011365)1.94920241
97Urethral obstruction (HP:0000796)1.92745493
98Congenital sensorineural hearing impairment (HP:0008527)1.92060466
99Abnormality of the costochondral junction (HP:0000919)1.91165856
100Alopecia of scalp (HP:0002293)1.90742101
101Generalized aminoaciduria (HP:0002909)1.90652042
102Hyperbilirubinemia (HP:0002904)1.89601333
103Flat acetabular roof (HP:0003180)1.89116329
104Abnormality of aspartate family amino acid metabolism (HP:0010899)1.86869960
105Amyloidosis (HP:0011034)1.85863746
106Milia (HP:0001056)1.84555527
107Polygenic inheritance (HP:0010982)1.84383680
108Abnormality of eosinophils (HP:0001879)1.83447368
109Cholecystitis (HP:0001082)1.82830339
110Abnormal gallbladder physiology (HP:0012438)1.82830339
111Systemic lupus erythematosus (HP:0002725)1.82529491
112Joint hemorrhage (HP:0005261)1.81217557
113Osteomalacia (HP:0002749)1.80879326
114Sensorimotor neuropathy (HP:0007141)1.79609180
115Hyperactive renin-angiotensin system (HP:0000841)1.79542418
116Thin bony cortex (HP:0002753)1.79415249
117Abnormal biliary tract morphology (HP:0012440)1.78932790
118Abnormality of the 1st metacarpal (HP:0010009)1.78150022
119Hypoalphalipoproteinemia (HP:0003233)1.76599667
120Abnormal urine phosphate concentration (HP:0012599)1.76373584
121Skin nodule (HP:0200036)1.75990215
122Peripheral demyelination (HP:0011096)1.75689009
123Increased serum ferritin (HP:0003281)1.73849571
124Abnormality of transition element cation homeostasis (HP:0011030)1.73649465
125Cheilitis (HP:0100825)1.72537928
126Pancreatitis (HP:0001733)1.70282730
127* Metabolic acidosis (HP:0001942)1.69788626
128Petechiae (HP:0000967)1.69441172
129Renal tubular dysfunction (HP:0000124)1.69261205
130Pili torti (HP:0003777)1.68977361
131Abnormality of sulfur amino acid metabolism (HP:0004339)1.68650414
132Bundle branch block (HP:0011710)1.67866243
133Prolonged neonatal jaundice (HP:0006579)1.67323014
134Abnormality of chloride homeostasis (HP:0011422)1.67045442
135Hypophosphatemia (HP:0002148)1.66045281
136Irritability (HP:0000737)1.65966484
137Fragile skin (HP:0001030)1.64709705
138Hyperparathyroidism (HP:0000843)1.64515269
139Abnormality of serum amino acid levels (HP:0003112)1.63594402
140Myopathic facies (HP:0002058)1.63571383
141Methylmalonic aciduria (HP:0012120)1.63234952
142Abnormality of potassium homeostasis (HP:0011042)1.62907949
143Joint swelling (HP:0001386)1.62683921
144Hypokalemia (HP:0002900)1.62317607
145Absent rod-and cone-mediated responses on ERG (HP:0007688)1.61551354
146Nausea (HP:0002018)1.61268167
147Abnormal albumin level (HP:0012116)1.60736320
148Hypoalbuminemia (HP:0003073)1.60736320
149Palpitations (HP:0001962)1.59542956
150Bilateral sensorineural hearing impairment (HP:0008619)1.59166030
151Hypophosphatemic rickets (HP:0004912)1.58797759
152Abnormality of iron homeostasis (HP:0011031)1.56940018
153Dicarboxylic aciduria (HP:0003215)1.56251968

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B8.19323929
2PIK3CG7.90010540
3MUSK6.83333857
4MST45.85250743
5FRK5.61930984
6AKT34.20335543
7GRK63.99450198
8NME13.96814202
9LMTK23.72441276
10MST1R3.60006124
11EPHA23.29903958
12PRKG23.15405778
13MAP3K103.04083090
14RIPK12.44521920
15PDK22.32595660
16NUAK12.20786710
17MAP3K22.19272585
18ERN11.88056145
19PTK61.77252968
20NLK1.65793234
21MAP2K21.60695221
22MAP3K91.56819242
23STK101.50315360
24RIPK41.49242979
25MAP3K71.37224575
26KSR21.35775961
27EPHA41.35089253
28BCKDK1.29684485
29DDR21.22985430
30STK391.22547403
31TAOK11.21317752
32EPHB21.19458020
33MET1.14720823
34TNIK1.13136844
35TESK21.08818507
36BMX1.06049349
37WNK31.05964859
38PRKCI1.02157222
39EPHB10.99171780
40TAOK30.98661906
41PIM10.96327490
42OXSR10.96015272
43MATK0.94804810
44MAP3K80.94601394
45PRKAA20.84167342
46FGFR20.84109408
47FER0.81385331
48NTRK30.80815443
49CDK120.78488310
50CASK0.77462534
51PTK20.76983476
52PBK0.75710125
53MAP3K10.74412481
54TESK10.70441390
55PDPK10.65202800
56TBK10.63627965
57BRSK20.63601212
58DMPK0.63352168
59LATS10.61528136
60ERBB20.61386324
61MAP3K110.61265938
62TTK0.61164020
63MAP2K60.60685574
64ICK0.57377446
65FGFR40.56978846
66BMPR1B0.54656840
67NEK90.54461647
68SCYL20.54058255
69ARAF0.51684835
70CDK50.51330291
71NEK60.50742397
72TEC0.50613605
73MAPK110.48394758
74PDK10.48085141
75PAK30.47177408
76TYK20.46710859
77IRAK10.45425103
78MAP2K10.43818200
79EPHA30.41684161
80ADRBK20.41600163
81CDK190.39216409
82BRAF0.38696336
83PTK2B0.38641639
84PRKCA0.36717468
85STK110.36060918
86FGR0.35524610
87JAK10.34883494
88MARK30.34338289
89PRKAA10.33548281
90ABL20.33503709
91KSR10.33495077
92FGFR30.32836112
93SYK0.32676586
94ITK0.32175160
95MYLK0.32073430
96STK240.31477428
97PAK40.31380815
98MARK20.31101847
99CAMK2B0.31048734
100TYRO30.30785808
101PRKD30.30614086
102PRKCE0.30049934
103SRC0.29812886
104FYN0.29639693
105IRAK20.29351237
106BRD40.27933393
107PRKCQ0.27791292
108MELK0.27467117
109INSRR0.26246008
110CSNK1A10.25891656
111RAF10.25879630
112PRKACB0.25712066
113PRKACG0.24714389
114MAP3K130.24349067
115MAP4K10.23501340
116WNK40.23185159
117MKNK20.23106627
118BTK0.23028276
119PAK20.22671064
120GRK10.22546622
121MAPK150.21564744
122DYRK1B0.20914001
123GRK50.20155077
124BMPR20.19930830
125MAP3K30.18251955
126MAP3K120.18236923
127CSK0.17898477
128PRKCD0.17498359
129AKT20.17203250
130LRRK20.17009555
131CSF1R0.16839560
132PRKACA0.16829902
133IRAK30.16707637
134PRKCB0.16170807
135PRKCG0.15890185
136OBSCN0.15692662
137RPS6KA30.15109293
138CDK60.15018465
139SGK30.14967648
140JAK20.14373412
141ROCK10.13467983
142ADRBK10.13150882
143PIM20.12793502
144CAMK2D0.12435311
145PRKCZ0.12211700
146CDK11A0.12033893
147ERBB40.11714654
148CAMK2A0.11596649
149TLK10.11086054
150PRKG10.10414911
151LYN0.09853963

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049756.30661096
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005245.36333551
3Renin-angiotensin system_Homo sapiens_hsa046145.32937586
4Vitamin digestion and absorption_Homo sapiens_hsa049774.35972424
5Caffeine metabolism_Homo sapiens_hsa002323.93374234
6Mineral absorption_Homo sapiens_hsa049783.79341474
7Starch and sucrose metabolism_Homo sapiens_hsa005003.16035907
8Linoleic acid metabolism_Homo sapiens_hsa005912.90584752
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.84295378
10* Carbohydrate digestion and absorption_Homo sapiens_hsa049732.45957824
11Folate biosynthesis_Homo sapiens_hsa007902.33890727
12Protein digestion and absorption_Homo sapiens_hsa049742.26397784
13* Galactose metabolism_Homo sapiens_hsa000522.11014509
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.05317065
15Bile secretion_Homo sapiens_hsa049761.89340645
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.84839257
17Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.77019841
18Fructose and mannose metabolism_Homo sapiens_hsa000511.63603713
19Arachidonic acid metabolism_Homo sapiens_hsa005901.59104423
20Sphingolipid metabolism_Homo sapiens_hsa006001.53565458
21Ether lipid metabolism_Homo sapiens_hsa005651.50884856
22Histidine metabolism_Homo sapiens_hsa003401.37562415
23Sulfur metabolism_Homo sapiens_hsa009201.34817113
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.34134898
25PPAR signaling pathway_Homo sapiens_hsa033201.26994053
26Glycerolipid metabolism_Homo sapiens_hsa005611.19365958
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.19308299
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12732631
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08086642
30Arginine biosynthesis_Homo sapiens_hsa002201.08062357
31Tryptophan metabolism_Homo sapiens_hsa003801.05644148
32Glutathione metabolism_Homo sapiens_hsa004801.03590225
33Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.03317848
34ABC transporters_Homo sapiens_hsa020100.92110844
35Nitrogen metabolism_Homo sapiens_hsa009100.84648799
36Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79685223
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78615938
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78333539
39Type II diabetes mellitus_Homo sapiens_hsa049300.74981672
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71718667
41Arginine and proline metabolism_Homo sapiens_hsa003300.71482920
42Drug metabolism - other enzymes_Homo sapiens_hsa009830.67686382
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67575707
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66586911
45Fatty acid degradation_Homo sapiens_hsa000710.62595168
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62349129
47Phenylalanine metabolism_Homo sapiens_hsa003600.60179753
48Glycerophospholipid metabolism_Homo sapiens_hsa005640.56224904
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55567115
50Gastric acid secretion_Homo sapiens_hsa049710.54606855
51Renin secretion_Homo sapiens_hsa049240.52492050
52Tight junction_Homo sapiens_hsa045300.51219841
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51018180
54Retinol metabolism_Homo sapiens_hsa008300.50848470
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50032608
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47940854
57Salivary secretion_Homo sapiens_hsa049700.47775409
58Butanoate metabolism_Homo sapiens_hsa006500.47386631
59Insulin secretion_Homo sapiens_hsa049110.46970721
60Thyroid hormone synthesis_Homo sapiens_hsa049180.46227598
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44915319
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42929176
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41791741
64Chemical carcinogenesis_Homo sapiens_hsa052040.40962381
65African trypanosomiasis_Homo sapiens_hsa051430.40336079
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39191002
67Complement and coagulation cascades_Homo sapiens_hsa046100.39142496
68Carbon metabolism_Homo sapiens_hsa012000.37707902
69GnRH signaling pathway_Homo sapiens_hsa049120.37585077
70Pancreatic secretion_Homo sapiens_hsa049720.36825274
71Fatty acid elongation_Homo sapiens_hsa000620.36589145
72Pyruvate metabolism_Homo sapiens_hsa006200.33946062
73Fatty acid biosynthesis_Homo sapiens_hsa000610.33652396
74Ovarian steroidogenesis_Homo sapiens_hsa049130.31407156
75beta-Alanine metabolism_Homo sapiens_hsa004100.31180609
76Salmonella infection_Homo sapiens_hsa051320.27164296
77Pentose phosphate pathway_Homo sapiens_hsa000300.27116407
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.26776716
79Propanoate metabolism_Homo sapiens_hsa006400.26773530
80Amphetamine addiction_Homo sapiens_hsa050310.26047464
81Tyrosine metabolism_Homo sapiens_hsa003500.25746945
82Long-term potentiation_Homo sapiens_hsa047200.23512473
83Lysine degradation_Homo sapiens_hsa003100.22880496
84Bladder cancer_Homo sapiens_hsa052190.22670283
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.21845155
86Long-term depression_Homo sapiens_hsa047300.19675504
87Peroxisome_Homo sapiens_hsa041460.19614146
88Adherens junction_Homo sapiens_hsa045200.19365825
89Cocaine addiction_Homo sapiens_hsa050300.19361014
90Gap junction_Homo sapiens_hsa045400.18158296
91Selenocompound metabolism_Homo sapiens_hsa004500.15998456
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.15733803
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.15446268
94Inositol phosphate metabolism_Homo sapiens_hsa005620.14759675
95Circadian entrainment_Homo sapiens_hsa047130.14729778
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.13882071
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.13673094
98Other glycan degradation_Homo sapiens_hsa005110.13438284
99Choline metabolism in cancer_Homo sapiens_hsa052310.12509723
100Hematopoietic cell lineage_Homo sapiens_hsa046400.12465694
101Insulin resistance_Homo sapiens_hsa049310.12251648
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.11863609
103Thyroid cancer_Homo sapiens_hsa052160.11496988
104Biosynthesis of amino acids_Homo sapiens_hsa012300.11435093
105Intestinal immune network for IgA production_Homo sapiens_hsa046720.11150077
106Cholinergic synapse_Homo sapiens_hsa047250.10465781
107Serotonergic synapse_Homo sapiens_hsa047260.10391253
108Glucagon signaling pathway_Homo sapiens_hsa049220.09554555
109Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.09485948
110* Metabolic pathways_Homo sapiens_hsa011000.09117807
111Fatty acid metabolism_Homo sapiens_hsa012120.08966962
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.08925794
113Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.07834786
114Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.07018359
115Asthma_Homo sapiens_hsa053100.06909374
116Estrogen signaling pathway_Homo sapiens_hsa049150.06760399
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.06682246
118Systemic lupus erythematosus_Homo sapiens_hsa053220.06428517
119Primary bile acid biosynthesis_Homo sapiens_hsa001200.06057832
120Hepatitis C_Homo sapiens_hsa051600.05993849
121Vibrio cholerae infection_Homo sapiens_hsa051100.05936747
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.05049425
123Staphylococcus aureus infection_Homo sapiens_hsa051500.04969563
124Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.04785527
125Dopaminergic synapse_Homo sapiens_hsa047280.04384394
126Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.03479894
127N-Glycan biosynthesis_Homo sapiens_hsa005100.02374246
128Autoimmune thyroid disease_Homo sapiens_hsa05320-0.0592128
129Graft-versus-host disease_Homo sapiens_hsa05332-0.0499459
130Sulfur relay system_Homo sapiens_hsa04122-0.0410114
131Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.0328662
132Allograft rejection_Homo sapiens_hsa05330-0.0320148

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