LDAH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)9.10193273
2central nervous system myelination (GO:0022010)7.79823026
3axon ensheathment in central nervous system (GO:0032291)7.79823026
4cholesterol biosynthetic process (GO:0006695)6.29691746
5long-chain fatty acid biosynthetic process (GO:0042759)5.74714441
6sterol biosynthetic process (GO:0016126)5.65587967
7long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)5.37558357
8long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.93025334
9fatty-acyl-CoA biosynthetic process (GO:0046949)4.90908418
10L-phenylalanine catabolic process (GO:0006559)4.68009993
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.68009993
12fatty-acyl-CoA metabolic process (GO:0035337)4.62170821
13very long-chain fatty acid metabolic process (GO:0000038)4.53235293
14isoprenoid biosynthetic process (GO:0008299)4.35302851
15protein neddylation (GO:0045116)4.34927379
16establishment of integrated proviral latency (GO:0075713)4.28118045
17thioester biosynthetic process (GO:0035384)4.28049801
18acyl-CoA biosynthetic process (GO:0071616)4.28049801
19nucleotide transmembrane transport (GO:1901679)4.26555664
20amyloid precursor protein metabolic process (GO:0042982)4.26149330
21myelination (GO:0042552)4.24602596
22axon ensheathment (GO:0008366)4.21935896
23ensheathment of neurons (GO:0007272)4.21935896
24L-phenylalanine metabolic process (GO:0006558)4.17190738
25erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.17190738
26L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.04291156
27L-methionine salvage (GO:0071267)3.98148465
28L-methionine biosynthetic process (GO:0071265)3.98148465
29amino acid salvage (GO:0043102)3.98148465
30DNA ligation (GO:0006266)3.90990854
31amyloid precursor protein catabolic process (GO:0042987)3.82464724
32regulation of pigment cell differentiation (GO:0050932)3.80870007
33GPI anchor biosynthetic process (GO:0006506)3.74136994
34chromatin remodeling at centromere (GO:0031055)3.73744635
35thioester metabolic process (GO:0035383)3.68228168
36acyl-CoA metabolic process (GO:0006637)3.68228168
37CENP-A containing nucleosome assembly (GO:0034080)3.67156418
38DNA damage response, detection of DNA damage (GO:0042769)3.61596214
39aldehyde catabolic process (GO:0046185)3.60549338
40preassembly of GPI anchor in ER membrane (GO:0016254)3.58540266
41DNA double-strand break processing (GO:0000729)3.57989647
42response to redox state (GO:0051775)3.56812155
43GPI anchor metabolic process (GO:0006505)3.55665058
44inner mitochondrial membrane organization (GO:0007007)3.52012907
45aromatic amino acid family catabolic process (GO:0009074)3.51613039
46DNA strand elongation involved in DNA replication (GO:0006271)3.51384935
47chaperone-mediated protein transport (GO:0072321)3.50017041
48mannosylation (GO:0097502)3.45459077
49regulation of collateral sprouting (GO:0048670)3.44178570
50establishment of viral latency (GO:0019043)3.39939158
51glycerophospholipid catabolic process (GO:0046475)3.37106767
52DNA strand elongation (GO:0022616)3.33878869
53L-serine metabolic process (GO:0006563)3.30794077
54mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.26010185
55signal peptide processing (GO:0006465)3.25515133
56double-strand break repair via nonhomologous end joining (GO:0006303)3.24980883
57non-recombinational repair (GO:0000726)3.24980883
58heme transport (GO:0015886)3.24600595
59steroid biosynthetic process (GO:0006694)3.23049579
60pyrimidine-containing compound transmembrane transport (GO:0072531)3.22861818
61negative regulation of neurotransmitter secretion (GO:0046929)3.20631683
62establishment of protein localization to mitochondrial membrane (GO:0090151)3.19377052
63negative regulation of neurotransmitter transport (GO:0051589)3.16520874
64positive regulation of cellular amine metabolic process (GO:0033240)3.16134349
65mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.15997332
66telomere maintenance via semi-conservative replication (GO:0032201)3.15314469
67cullin deneddylation (GO:0010388)3.15107046
68nucleotide transport (GO:0006862)3.14880443
69regulation of mitochondrial translation (GO:0070129)3.13147457
70spindle checkpoint (GO:0031577)3.10844844
71mitotic spindle checkpoint (GO:0071174)3.08740635
72mitochondrial respiratory chain complex I assembly (GO:0032981)3.07807982
73NADH dehydrogenase complex assembly (GO:0010257)3.07807982
74mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.07807982
75glycosylceramide metabolic process (GO:0006677)3.06328547
76DNA replication-independent nucleosome assembly (GO:0006336)3.04710490
77DNA replication-independent nucleosome organization (GO:0034724)3.04710490
78DNA topological change (GO:0006265)3.04380922
79negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.04375629
80negative regulation of mitotic sister chromatid segregation (GO:0033048)3.04375629
81negative regulation of mitotic sister chromatid separation (GO:2000816)3.04375629
82negative regulation of sister chromatid segregation (GO:0033046)3.04375629
83negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.04375629
84substantia nigra development (GO:0021762)3.03271302
85cofactor catabolic process (GO:0051187)3.02756116
86ATP synthesis coupled proton transport (GO:0015986)3.00929149
87energy coupled proton transport, down electrochemical gradient (GO:0015985)3.00929149
88negative regulation of DNA recombination (GO:0045910)3.00320065
89negative regulation of chromosome segregation (GO:0051985)3.00113831
90exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.99049771
91DNA replication checkpoint (GO:0000076)2.98842530
92protein localization to kinetochore (GO:0034501)2.98503999
93regulation of lipoprotein metabolic process (GO:0050746)2.97996291
94coenzyme A metabolic process (GO:0015936)2.97733858
95response to methylmercury (GO:0051597)2.96229522
96acetyl-CoA metabolic process (GO:0006084)2.95755326
97histone exchange (GO:0043486)2.95489659
98alcohol biosynthetic process (GO:0046165)2.95279553
99DNA strand renaturation (GO:0000733)2.95137578
100peptidyl-histidine modification (GO:0018202)2.94326806
101nucleotide-excision repair, DNA gap filling (GO:0006297)2.94308712
102coenzyme catabolic process (GO:0009109)2.94123742
103oligodendrocyte differentiation (GO:0048709)2.92705231
104viral protein processing (GO:0019082)2.92004458
105nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.91295503
106mitotic spindle assembly checkpoint (GO:0007094)2.91287713
107protein deneddylation (GO:0000338)2.88480524
108spindle assembly checkpoint (GO:0071173)2.87915866
109cholesterol metabolic process (GO:0008203)2.87770679
110somatic hypermutation of immunoglobulin genes (GO:0016446)2.87660272
111somatic diversification of immune receptors via somatic mutation (GO:0002566)2.87660272
112bile acid biosynthetic process (GO:0006699)2.86255670
113regulation of mitotic spindle checkpoint (GO:1903504)2.85613649
114regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.85613649
115negative regulation of protein localization to cell surface (GO:2000009)2.85071581
116protein complex biogenesis (GO:0070271)2.84785341
117mitotic recombination (GO:0006312)2.84600382
118branched-chain amino acid catabolic process (GO:0009083)2.84068968
119C-terminal protein lipidation (GO:0006501)2.80841972
120sister chromatid segregation (GO:0000819)2.80839579
121DNA catabolic process, exonucleolytic (GO:0000738)2.77734365
122regulation of helicase activity (GO:0051095)2.77442691
123fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.76726975
124mitotic sister chromatid segregation (GO:0000070)2.75889147
125transcription elongation from RNA polymerase III promoter (GO:0006385)2.74329050
126termination of RNA polymerase III transcription (GO:0006386)2.74329050
127kinetochore organization (GO:0051383)2.74312907
128regulation of mitotic metaphase/anaphase transition (GO:0030071)2.74304570
129regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.74304570
130spliceosomal snRNP assembly (GO:0000387)2.74122042
131water-soluble vitamin biosynthetic process (GO:0042364)2.73993435
132purine nucleobase biosynthetic process (GO:0009113)2.73868621
133mitotic sister chromatid cohesion (GO:0007064)2.73431774
134tRNA aminoacylation for protein translation (GO:0006418)2.73215432
135tRNA aminoacylation (GO:0043039)2.72520425
136amino acid activation (GO:0043038)2.72520425
137tyrosine metabolic process (GO:0006570)2.71470621
138respiratory chain complex IV assembly (GO:0008535)2.71358972
139telomere maintenance via recombination (GO:0000722)2.70804851
140sterol metabolic process (GO:0016125)2.70452341
141ubiquinone metabolic process (GO:0006743)2.70432274
142myelin maintenance (GO:0043217)2.69459786
143respiratory electron transport chain (GO:0022904)2.68679556
144creatine metabolic process (GO:0006600)2.67694760
145triglyceride biosynthetic process (GO:0019432)2.67157499
146negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.67137123
147mitotic metaphase plate congression (GO:0007080)2.66601271
148regulation of sister chromatid segregation (GO:0033045)2.66001432
149regulation of mitotic sister chromatid separation (GO:0010965)2.66001432
150regulation of mitotic sister chromatid segregation (GO:0033047)2.66001432
151base-excision repair (GO:0006284)2.65724620
152DNA unwinding involved in DNA replication (GO:0006268)2.65422637
153fatty acid biosynthetic process (GO:0006633)2.64398427
154developmental pigmentation (GO:0048066)2.64328007
155proteasome assembly (GO:0043248)2.63917648
156histone H2A acetylation (GO:0043968)2.63901946
157replication fork processing (GO:0031297)2.63786437
158histone mRNA metabolic process (GO:0008334)2.63428640
159response to lipoprotein particle (GO:0055094)2.62190329
160aromatic amino acid family metabolic process (GO:0009072)2.61963815
161regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.61540110
162single strand break repair (GO:0000012)2.61453789
163electron transport chain (GO:0022900)2.61355027
164glyoxylate metabolic process (GO:0046487)2.60704449
165peptidyl-cysteine modification (GO:0018198)2.60178844
166kinetochore assembly (GO:0051382)2.59309032
167nucleoside diphosphate catabolic process (GO:0009134)2.59025950
168negative regulation of acute inflammatory response (GO:0002674)2.58469601
169protein localization to chromosome, centromeric region (GO:0071459)2.57747453
170carbohydrate derivative transport (GO:1901264)2.57521241
171regulation of chromosome segregation (GO:0051983)2.57159970
172intraciliary transport (GO:0042073)2.56081346
173ATP-dependent chromatin remodeling (GO:0043044)2.55371425
174positive regulation of oligodendrocyte differentiation (GO:0048714)2.54813871
175neutral lipid biosynthetic process (GO:0046460)2.53665843
176microtubule depolymerization (GO:0007019)2.52694663
177protein K11-linked ubiquitination (GO:0070979)2.52601169
178anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.51892266
179resolution of meiotic recombination intermediates (GO:0000712)2.51208804
180nuclear pore organization (GO:0006999)2.50962578
181transcription-coupled nucleotide-excision repair (GO:0006283)2.48350407
182pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.46883192
183negative regulation of mitosis (GO:0045839)2.46710853
184IMP biosynthetic process (GO:0006188)2.45983475
185formation of translation preinitiation complex (GO:0001731)2.45973152
186ribosome assembly (GO:0042255)2.44247600
187cytochrome complex assembly (GO:0017004)2.44040796
188nuclear pore complex assembly (GO:0051292)2.43068874
189mitochondrial respiratory chain complex assembly (GO:0033108)2.42935460

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.21653987
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.18432333
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.69525199
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.65904577
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.58852198
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.53296989
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.16347304
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.15423384
9RBPJ_22232070_ChIP-Seq_NCS_Mouse3.00655449
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.96665921
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.93060080
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.87428043
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.87279714
14PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.72152218
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.69930719
16IGF1R_20145208_ChIP-Seq_DFB_Human2.66760325
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.66168188
18CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.62190184
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.56781228
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.44373773
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.35014082
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.32825693
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.23037425
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.22243037
25IRF8_21731497_ChIP-ChIP_J774_Mouse2.17071816
26KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.15229090
27CREB1_15753290_ChIP-ChIP_HEK293T_Human2.14146355
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.13501807
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.11083456
30TAF15_26573619_Chip-Seq_HEK293_Human2.09721751
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08376055
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.06211576
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.04909537
34SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.00254943
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.93002749
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.90176136
37GBX2_23144817_ChIP-Seq_PC3_Human1.89791591
38FOXP3_21729870_ChIP-Seq_TREG_Human1.88622173
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.87374844
40RXR_22158963_ChIP-Seq_LIVER_Mouse1.84456654
41VDR_22108803_ChIP-Seq_LS180_Human1.83496293
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82279166
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.80874946
44FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.75437898
45ZNF274_21170338_ChIP-Seq_K562_Hela1.72133607
46AR_21909140_ChIP-Seq_LNCAP_Human1.71382973
47MYC_18358816_ChIP-ChIP_MESCs_Mouse1.71023251
48NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71022803
49HTT_18923047_ChIP-ChIP_STHdh_Human1.68730614
50MYC_19079543_ChIP-ChIP_MESCs_Mouse1.68310041
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.64639175
52SOX2_16153702_ChIP-ChIP_HESCs_Human1.60928223
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60477185
54TTF2_22483619_ChIP-Seq_HELA_Human1.60348121
55LXR_22158963_ChIP-Seq_LIVER_Mouse1.59739932
56GABP_19822575_ChIP-Seq_HepG2_Human1.56677180
57MYC_18940864_ChIP-ChIP_HL60_Human1.55105165
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.54659809
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.52936941
60DCP1A_22483619_ChIP-Seq_HELA_Human1.51568478
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48645246
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48533619
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48437864
64EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.46895397
65IRF1_19129219_ChIP-ChIP_H3396_Human1.45133608
66MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.45101355
67PPARA_22158963_ChIP-Seq_LIVER_Mouse1.42246649
68NANOG_16153702_ChIP-ChIP_HESCs_Human1.41202824
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.40770804
70ER_23166858_ChIP-Seq_MCF-7_Human1.40652200
71POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.39787513
72XRN2_22483619_ChIP-Seq_HELA_Human1.39509137
73STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.37481587
74NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.36730493
75NRF2_20460467_ChIP-Seq_MEFs_Mouse1.36730493
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36056426
77EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.35050450
78NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34446319
79PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.33822922
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32704998
81ETS1_20019798_ChIP-Seq_JURKAT_Human1.31280016
82SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.28735355
83MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.28326272
84IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.26011206
85PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.24077347
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22997884
87ELK1_19687146_ChIP-ChIP_HELA_Human1.18031317
88ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17883394
89SOX17_20123909_ChIP-Seq_XEN_Mouse1.15773939
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14051856
91RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.13772900
92SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11450801
93FLI1_27457419_Chip-Seq_LIVER_Mouse1.11380943
94SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11364387
95FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10977355
96FUS_26573619_Chip-Seq_HEK293_Human1.10831246
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10611917
98LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10454281
99YY1_21170310_ChIP-Seq_MESCs_Mouse1.10298445
100RUNX1_27457419_Chip-Seq_LIVER_Mouse1.08829950
101CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08126528
102PIAS1_25552417_ChIP-Seq_VCAP_Human1.07803137
103CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07562578
104TP63_19390658_ChIP-ChIP_HaCaT_Human1.07364660
105TAL1_26923725_Chip-Seq_HPCs_Mouse1.05955231
106CMYC_18555785_Chip-Seq_ESCs_Mouse1.05032735
107P300_18555785_Chip-Seq_ESCs_Mouse1.04787184
108KDM5A_27292631_Chip-Seq_BREAST_Human1.03218377
109STAT3_18555785_Chip-Seq_ESCs_Mouse1.01700927
110PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01322564
111P300_19829295_ChIP-Seq_ESCs_Human1.01066333
112MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99586286
113SMAD1_18555785_Chip-Seq_ESCs_Mouse0.99165872
114CRX_20693478_ChIP-Seq_RETINA_Mouse0.97184566
115EWS_26573619_Chip-Seq_HEK293_Human0.96795593
116THAP11_20581084_ChIP-Seq_MESCs_Mouse0.96215763
117NOTCH1_21737748_ChIP-Seq_TLL_Human0.95407636
118HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.94527225
119EZH2_27294783_Chip-Seq_NPCs_Mouse0.94367722
120FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.93907678
121EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.93172059
122EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93116398
123CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92799844
124NANOG_18555785_Chip-Seq_ESCs_Mouse0.92163069
125PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91373001
126NANOG_19829295_ChIP-Seq_ESCs_Human0.91235134
127SOX2_19829295_ChIP-Seq_ESCs_Human0.91235134
128ELK1_22589737_ChIP-Seq_MCF10A_Human0.91206850
129MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91052931
130NCOR_22424771_ChIP-Seq_293T_Human0.90302977
131E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89654165
132SALL4_22934838_ChIP-ChIP_CD34+_Human0.89617364
133FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.89587216
134P53_22387025_ChIP-Seq_ESCs_Mouse0.89304671
135SOX2_18555785_Chip-Seq_ESCs_Mouse0.88309916
136EGR1_19032775_ChIP-ChIP_M12_Human0.86571132
137SOX9_26525672_Chip-Seq_HEART_Mouse0.86334021
138SMAD3_21741376_ChIP-Seq_EPCs_Human0.84498121
139SUZ12_27294783_Chip-Seq_NPCs_Mouse0.84016597
140KLF4_18555785_Chip-Seq_ESCs_Mouse0.83677639
141NMYC_18555785_Chip-Seq_ESCs_Mouse0.83469040
142PU1_27457419_Chip-Seq_LIVER_Mouse0.83162377
143OCT4_18555785_Chip-Seq_ESCs_Mouse0.82598673
144NANOG_18555785_ChIP-Seq_MESCs_Mouse0.82262681
145HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.82156532
146NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.81508245
147VDR_23849224_ChIP-Seq_CD4+_Human0.81216822
148RNF2_27304074_Chip-Seq_NSC_Mouse0.80715779
149LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80640332
150ESR1_20079471_ChIP-ChIP_T-47D_Human0.80555803
151AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.80525990
152HOXB4_20404135_ChIP-ChIP_EML_Mouse0.79979739
153CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.79497724
154PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.79380876
155ZFX_18555785_Chip-Seq_ESCs_Mouse0.78881382
156EOMES_21245162_ChIP-Seq_HESCs_Human0.78332202
157PCGF2_27294783_Chip-Seq_NPCs_Mouse0.78241215
158SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.77209250
159E2F1_18555785_ChIP-Seq_MESCs_Mouse0.76543290
160FOXA1_21572438_ChIP-Seq_LNCaP_Human0.75916518
161TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.75869920
162AR_20517297_ChIP-Seq_VCAP_Human0.75222094

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.43677835
2MP0009379_abnormal_foot_pigmentation4.27371189
3MP0000920_abnormal_myelination3.92546237
4MP0008058_abnormal_DNA_repair3.35591169
5MP0002139_abnormal_hepatobiliary_system3.34072699
6MP0003195_calcinosis3.18322044
7MP0006292_abnormal_olfactory_placode3.14022348
8MP0010094_abnormal_chromosome_stability2.94938644
9MP0005409_darkened_coat_color2.94518107
10MP0004381_abnormal_hair_follicle2.88060298
11MP0004147_increased_porphyrin_level2.84332514
12MP0003122_maternal_imprinting2.81249902
13MP0003693_abnormal_embryo_hatching2.73889023
14MP0003890_abnormal_embryonic-extraembry2.63946792
15MP0001529_abnormal_vocalization2.57985832
16MP0005085_abnormal_gallbladder_physiolo2.55007221
17MP0005451_abnormal_body_composition2.54403825
18MP0003111_abnormal_nucleus_morphology2.46549963
19MP0001905_abnormal_dopamine_level2.45156416
20MP0008932_abnormal_embryonic_tissue2.39292568
21MP0003329_amyloid_beta_deposits2.36040661
22MP0004957_abnormal_blastocyst_morpholog2.33846836
23MP0001188_hyperpigmentation2.32698205
24MP0002102_abnormal_ear_morphology2.31284555
25MP0003950_abnormal_plasma_membrane2.30052765
26MP0002876_abnormal_thyroid_physiology2.28625233
27MP0003690_abnormal_glial_cell2.27099025
28MP0003121_genomic_imprinting2.20426118
29MP0001293_anophthalmia2.16967959
30MP0003787_abnormal_imprinting2.10990720
31MP0005365_abnormal_bile_salt2.09592133
32MP0008057_abnormal_DNA_replication2.08955888
33MP0008875_abnormal_xenobiotic_pharmacok2.08273695
34MP0005360_urolithiasis2.06185439
35MP0008260_abnormal_autophagy2.06027403
36MP0008877_abnormal_DNA_methylation2.02876676
37MP0005171_absent_coat_pigmentation1.99437363
38MP0003077_abnormal_cell_cycle1.98687625
39MP0004142_abnormal_muscle_tone1.93797203
40MP0005058_abnormal_lysosome_morphology1.90395744
41MP0005332_abnormal_amino_acid1.83721837
42MP0003941_abnormal_skin_development1.79273947
43MP0003186_abnormal_redox_activity1.79273812
44MP0004043_abnormal_pH_regulation1.75764606
45MP0003567_abnormal_fetal_cardiomyocyte1.75614337
46MP0005408_hypopigmentation1.75318590
47MP0008007_abnormal_cellular_replicative1.73346415
48MP0003937_abnormal_limbs/digits/tail_de1.72975718
49MP0003136_yellow_coat_color1.72330401
50MP0001986_abnormal_taste_sensitivity1.69967673
51MP0000604_amyloidosis1.67093269
52MP0003880_abnormal_central_pattern1.62383893
53MP0002751_abnormal_autonomic_nervous1.62210465
54MP0008789_abnormal_olfactory_epithelium1.61520337
55MP0000569_abnormal_digit_pigmentation1.59685131
56MP0005083_abnormal_biliary_tract1.58339045
57MP0002233_abnormal_nose_morphology1.57117296
58MP0005499_abnormal_olfactory_system1.57027029
59MP0005394_taste/olfaction_phenotype1.57027029
60MP0000015_abnormal_ear_pigmentation1.56941318
61MP0003011_delayed_dark_adaptation1.56941041
62MP0004742_abnormal_vestibular_system1.55603113
63MP0000566_synostosis1.54616631
64MP0006072_abnormal_retinal_apoptosis1.52976299
65MP0001286_abnormal_eye_development1.52953852
66MP0001661_extended_life_span1.52195057
67MP0001764_abnormal_homeostasis1.51399469
68MP0000778_abnormal_nervous_system1.48842330
69MP0009840_abnormal_foam_cell1.48111550
70MP0003718_maternal_effect1.45185393
71MP0004133_heterotaxia1.42533277
72MP0001984_abnormal_olfaction1.39894161
73MP0002118_abnormal_lipid_homeostasis1.36645024
74MP0002697_abnormal_eye_size1.35009794
75MP0003632_abnormal_nervous_system1.34950063
76MP0006082_CNS_inflammation1.33027681
77MP0003634_abnormal_glial_cell1.28938382
78MP0005253_abnormal_eye_physiology1.28137202
79MP0010030_abnormal_orbit_morphology1.27061181
80MP0001485_abnormal_pinna_reflex1.26390343
81MP0000372_irregular_coat_pigmentation1.25499204
82MP0005075_abnormal_melanosome_morpholog1.24896206
83MP0005379_endocrine/exocrine_gland_phen1.23876712
84MP0003315_abnormal_perineum_morphology1.23576574
85MP0002272_abnormal_nervous_system1.23469444
86MP0005584_abnormal_enzyme/coenzyme_acti1.22170629
87MP0003656_abnormal_erythrocyte_physiolo1.21782345
88MP0003123_paternal_imprinting1.21748089
89MP0009697_abnormal_copulation1.19577326
90MP0000049_abnormal_middle_ear1.19036349
91MP0002084_abnormal_developmental_patter1.17477650
92MP0005187_abnormal_penis_morphology1.16834741
93MP0005391_vision/eye_phenotype1.16392119
94MP0003938_abnormal_ear_development1.14260355
95MP0002938_white_spotting1.14085859
96MP0002229_neurodegeneration1.13175907
97MP0001697_abnormal_embryo_size1.13174788
98MP0006036_abnormal_mitochondrial_physio1.12034431
99MP0010329_abnormal_lipoprotein_level1.11800427
100MP0002234_abnormal_pharynx_morphology1.10175603
101MP0000647_abnormal_sebaceous_gland1.10156119
102MP0001666_abnormal_nutrient_absorption1.08915273
103MP0003786_premature_aging1.08167770
104MP0003119_abnormal_digestive_system1.07687509
105MP0002085_abnormal_embryonic_tissue1.06593759
106MP0005248_abnormal_Harderian_gland1.06158947
107MP0002092_abnormal_eye_morphology1.04964001
108MP0003861_abnormal_nervous_system1.03365746
109MP0003191_abnormal_cellular_cholesterol1.02871703
110MP0001299_abnormal_eye_distance/1.02549839
111MP0000631_abnormal_neuroendocrine_gland1.01646525
112MP0001672_abnormal_embryogenesis/_devel1.00933765
113MP0005380_embryogenesis_phenotype1.00933765
114MP0004270_analgesia0.99020652
115MP0005174_abnormal_tail_pigmentation0.98975473
116MP0005646_abnormal_pituitary_gland0.96878690
117MP0009672_abnormal_birth_weight0.96598040
118MP0002148_abnormal_hypersensitivity_rea0.95193911
119MP0001730_embryonic_growth_arrest0.95023815
120MP0003755_abnormal_palate_morphology0.94695197
121MP0006035_abnormal_mitochondrial_morpho0.94448935
122MP0001324_abnormal_eye_pigmentation0.93458342
123MP0004019_abnormal_vitamin_homeostasis0.92276096
124MP0004197_abnormal_fetal_growth/weight/0.91559203
125MP0002064_seizures0.91446414
126MP0002638_abnormal_pupillary_reflex0.89997130
127MP0003631_nervous_system_phenotype0.89270854
128MP0005084_abnormal_gallbladder_morpholo0.89005553
129MP0002088_abnormal_embryonic_growth/wei0.87733132
130MP0001727_abnormal_embryo_implantation0.85806808
131MP0002210_abnormal_sex_determination0.85626491
132MP0000358_abnormal_cell_content/0.85375718
133MP0003984_embryonic_growth_retardation0.85109591
134MP0005423_abnormal_somatic_nervous0.84935727
135MP0003385_abnormal_body_wall0.84274881
136MP0002111_abnormal_tail_morphology0.84268504
137MP0001929_abnormal_gametogenesis0.84167023
138MP0009703_decreased_birth_body0.83633207
139MP0000350_abnormal_cell_proliferation0.82704044
140MP0003935_abnormal_craniofacial_develop0.80610700
141MP0005551_abnormal_eye_electrophysiolog0.80271558
142MP0005636_abnormal_mineral_homeostasis0.80263068
143MP0003724_increased_susceptibility_to0.79335134
144MP0004134_abnormal_chest_morphology0.78723132
145MP0002184_abnormal_innervation0.78450586
146MP0002080_prenatal_lethality0.77894845
147MP0009765_abnormal_xenobiotic_induced0.77488719
148MP0000653_abnormal_sex_gland0.77462324
149MP0003252_abnormal_bile_duct0.77349219
150MP0005195_abnormal_posterior_eye0.76908376
151MP0001177_atelectasis0.76847845
152MP0002736_abnormal_nociception_after0.76076637
153MP0002177_abnormal_outer_ear0.75727247
154MP0002752_abnormal_somatic_nervous0.75720171
155MP0002295_abnormal_pulmonary_circulatio0.75346863
156MP0001145_abnormal_male_reproductive0.75261944
157MP0002090_abnormal_vision0.74257423
158MP0001851_eye_inflammation0.74254909
159MP0008438_abnormal_cutaneous_collagen0.74185660
160MP0002163_abnormal_gland_morphology0.73701632
161MP0004885_abnormal_endolymph0.73391664
162MP0002282_abnormal_trachea_morphology0.72266784
163MP0006276_abnormal_autonomic_nervous0.71410497
164MP0001486_abnormal_startle_reflex0.70845124
165MP0002095_abnormal_skin_pigmentation0.70839885
166MP0000427_abnormal_hair_cycle0.70797717
167MP0002557_abnormal_social/conspecific_i0.70029730
168MP0009643_abnormal_urine_homeostasis0.66428121
169MP0000230_abnormal_systemic_arterial0.66314677
170MP0005410_abnormal_fertilization0.65562674
171MP0002933_joint_inflammation0.63610117
172MP0009785_altered_susceptibility_to0.62553781
173MP0000681_abnormal_thyroid_gland0.62201717
174MP0005395_other_phenotype0.60712832
175MP0002734_abnormal_mechanical_nocicepti0.59636702
176MP0002837_dystrophic_cardiac_calcinosis0.59188721
177MP0001346_abnormal_lacrimal_gland0.59091471
178MP0003633_abnormal_nervous_system0.56369321
179MP0001963_abnormal_hearing_physiology0.55400110
180MP0002822_catalepsy0.55066538
181MP0008469_abnormal_protein_level0.54699427
182MP0002419_abnormal_innate_immunity0.53554037
183MP0002132_abnormal_respiratory_system0.52735428

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolysis (HP:0004366)5.38947078
2Increased serum pyruvate (HP:0003542)5.38947078
3Parakeratosis (HP:0001036)5.08070805
4Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.39700112
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.11629425
6Degeneration of the lateral corticospinal tracts (HP:0002314)4.11629425
7Abnormality of aromatic amino acid family metabolism (HP:0004338)4.01055604
8Abnormality of the labia minora (HP:0012880)3.98442922
9Neurofibrillary tangles (HP:0002185)3.87721683
10Congenital ichthyosiform erythroderma (HP:0007431)3.71698666
11Cortical dysplasia (HP:0002539)3.64012016
12Acute necrotizing encephalopathy (HP:0006965)3.49930594
133-Methylglutaconic aciduria (HP:0003535)3.45856247
14Cerebral hypomyelination (HP:0006808)3.38842557
15Renal Fanconi syndrome (HP:0001994)3.36562290
16Acute encephalopathy (HP:0006846)3.33533227
17Intrahepatic cholestasis (HP:0001406)3.32025722
18Mitochondrial inheritance (HP:0001427)3.21512912
19Autoamputation (HP:0001218)3.19353650
20Hepatic necrosis (HP:0002605)3.16383617
21Hepatocellular necrosis (HP:0001404)3.12234302
22Hepatosplenomegaly (HP:0001433)3.11797640
23Sensory axonal neuropathy (HP:0003390)3.11626570
24Abnormal mitochondria in muscle tissue (HP:0008316)3.06857042
25Leukodystrophy (HP:0002415)2.99555954
26Prolonged neonatal jaundice (HP:0006579)2.98113340
27Hypobetalipoproteinemia (HP:0003563)2.95890927
28Colon cancer (HP:0003003)2.95367009
29Chromosomal breakage induced by crosslinking agents (HP:0003221)2.93234007
30Cerebral edema (HP:0002181)2.86046165
31Progressive macrocephaly (HP:0004481)2.85021888
32Conjugated hyperbilirubinemia (HP:0002908)2.81510541
33Methylmalonic acidemia (HP:0002912)2.77172874
34Spastic paraparesis (HP:0002313)2.74664953
35Abnormality of the corticospinal tract (HP:0002492)2.74576539
36Increased CSF lactate (HP:0002490)2.74134509
37Meckel diverticulum (HP:0002245)2.73178847
38Abnormality of chromosome stability (HP:0003220)2.70074196
39Chromsome breakage (HP:0040012)2.65856530
40Erythroderma (HP:0001019)2.65182450
41Abnormal lung lobation (HP:0002101)2.64892745
42Increased hepatocellular lipid droplets (HP:0006565)2.62226113
43Lipid accumulation in hepatocytes (HP:0006561)2.59089288
44Abnormality of the ileum (HP:0001549)2.53253292
45Prolonged partial thromboplastin time (HP:0003645)2.52733979
46Microvesicular hepatic steatosis (HP:0001414)2.52541146
47Aplasia/Hypoplasia of the uvula (HP:0010293)2.52296906
48Neuroendocrine neoplasm (HP:0100634)2.47881689
49Pheochromocytoma (HP:0002666)2.46642410
50Hyperlipoproteinemia (HP:0010980)2.45607006
51Hepatoblastoma (HP:0002884)2.44558897
52CNS hypomyelination (HP:0003429)2.44377417
53Peripheral hypomyelination (HP:0007182)2.40630105
54Reticulocytopenia (HP:0001896)2.40047413
55Medulloblastoma (HP:0002885)2.39295528
56Abnormality of methionine metabolism (HP:0010901)2.36929588
57Intestinal atresia (HP:0011100)2.34791814
58Brushfield spots (HP:0001088)2.34271701
59Cerebral hemorrhage (HP:0001342)2.27756684
60Cerebral inclusion bodies (HP:0100314)2.27546433
61Duodenal stenosis (HP:0100867)2.24267290
62Small intestinal stenosis (HP:0012848)2.24267290
63Birth length less than 3rd percentile (HP:0003561)2.21350710
64Steatorrhea (HP:0002570)2.21013006
65Abnormality of the duodenum (HP:0002246)2.19952398
66Xanthomatosis (HP:0000991)2.19563851
67Poor speech (HP:0002465)2.19055529
68Abnormality of fatty-acid metabolism (HP:0004359)2.18063043
69Fat malabsorption (HP:0002630)2.17676508
70Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.16282377
71Split foot (HP:0001839)2.16169543
72Opisthotonus (HP:0002179)2.15788701
73Abnormality of aspartate family amino acid metabolism (HP:0010899)2.15550180
74Abnormality of the preputium (HP:0100587)2.14760859
75Abnormality of renal resorption (HP:0011038)2.14578214
76True hermaphroditism (HP:0010459)2.13413415
77Renal cortical cysts (HP:0000803)2.13260483
78Spastic gait (HP:0002064)2.13218490
79Abnormality of glycine metabolism (HP:0010895)2.12860202
80Abnormality of serine family amino acid metabolism (HP:0010894)2.12860202
81Esophageal atresia (HP:0002032)2.12388361
82Hypoplasia of the thymus (HP:0000778)2.10985892
83Increased serum lactate (HP:0002151)2.10016423
84Respiratory failure (HP:0002878)2.08974278
85Abnormality of the metopic suture (HP:0005556)2.08686690
86Patchy hypopigmentation of hair (HP:0011365)2.08172246
87Lactic acidosis (HP:0003128)2.07974298
88Horseshoe kidney (HP:0000085)2.07836859
89Hypoplastic female external genitalia (HP:0012815)2.07543201
90Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.06957942
91Hyperglycinemia (HP:0002154)2.05045062
92Abnormality of serum amino acid levels (HP:0003112)2.04608853
93Lethargy (HP:0001254)2.03959891
94Methylmalonic aciduria (HP:0012120)2.03703654
95Sloping forehead (HP:0000340)2.03138354
96Supernumerary spleens (HP:0009799)2.03007330
97Abnormality of the parathyroid morphology (HP:0011766)2.02935138
98Nephroblastoma (Wilms tumor) (HP:0002667)2.02461936
99Triphalangeal thumb (HP:0001199)2.02234734
100Rhabdomyosarcoma (HP:0002859)2.01920903
101Acute hepatic failure (HP:0006554)2.00842514
102Labial hypoplasia (HP:0000066)2.00632275
103Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.00379295
104Abnormality of urine glucose concentration (HP:0011016)2.00276074
105Glycosuria (HP:0003076)2.00276074
106Anophthalmia (HP:0000528)2.00161925
107Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.98739459
108Dicarboxylic aciduria (HP:0003215)1.98400433
109Abnormality of dicarboxylic acid metabolism (HP:0010995)1.98400433
110Medial flaring of the eyebrow (HP:0010747)1.97973315
111White forelock (HP:0002211)1.97304306
112Embryonal renal neoplasm (HP:0011794)1.93365956
113CNS demyelination (HP:0007305)1.93044443
114High anterior hairline (HP:0009890)1.92191453
115Hypoglycemic coma (HP:0001325)1.91475681
116Congenital sensorineural hearing impairment (HP:0008527)1.91390402
117Hypoplastic pelvis (HP:0008839)1.89946245
118Hyperammonemia (HP:0001987)1.88316838
119Vacuolated lymphocytes (HP:0001922)1.87658671
120Clitoromegaly (HP:0000057)1.87367410
121Oligodactyly (hands) (HP:0001180)1.86901630
122Type I transferrin isoform profile (HP:0003642)1.86129516
123Neoplasm of the adrenal gland (HP:0100631)1.85875990
124Dandy-Walker malformation (HP:0001305)1.84945914
125Aplasia/hypoplasia of the uterus (HP:0008684)1.84723996
126Aqueductal stenosis (HP:0002410)1.84320402
127Hypophosphatemic rickets (HP:0004912)1.84256962
128Prominent metopic ridge (HP:0005487)1.83952814
129Glioma (HP:0009733)1.82712864
130Hip dysplasia (HP:0001385)1.81931535
131Hypoglycemic seizures (HP:0002173)1.81112241
132Epidermoid cyst (HP:0200040)1.80881584
133Optic disc pallor (HP:0000543)1.80532721
134Bifid tongue (HP:0010297)1.80288092
135Paraparesis (HP:0002385)1.78917103
136Ependymoma (HP:0002888)1.78533531
137Exertional dyspnea (HP:0002875)1.78461695
138Congenital primary aphakia (HP:0007707)1.78218612
139Gait imbalance (HP:0002141)1.77428777
140Hyperglycinuria (HP:0003108)1.77396136
141Recurrent corneal erosions (HP:0000495)1.77383289
142Deep venous thrombosis (HP:0002625)1.77364078
143Stenosis of the external auditory canal (HP:0000402)1.77303677
144Vaginal atresia (HP:0000148)1.77041397
145Stridor (HP:0010307)1.76537691
146Gastrointestinal atresia (HP:0002589)1.76250130
147Pancreatic islet-cell hyperplasia (HP:0004510)1.75615116
148Abnormality of the carotid arteries (HP:0005344)1.75447859
149Premature skin wrinkling (HP:0100678)1.75161821
150Pancreatic fibrosis (HP:0100732)1.74114792
15111 pairs of ribs (HP:0000878)1.72673084
152Genital tract atresia (HP:0001827)1.72532683
153Purpura (HP:0000979)1.71529450
154Preaxial hand polydactyly (HP:0001177)1.71415504
155Abnormality of monocarboxylic acid metabolism (HP:0010996)1.70656842
156Postnatal microcephaly (HP:0005484)1.70261397
157Limb dystonia (HP:0002451)1.69427631
158Hypoplasia of the capital femoral epiphysis (HP:0003090)1.69367833
159Hypothermia (HP:0002045)1.68960862
160Nephrogenic diabetes insipidus (HP:0009806)1.68242313
161Scrotal hypoplasia (HP:0000046)1.67982517
162Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.67283479
163Adrenal hypoplasia (HP:0000835)1.66743966
164X-linked dominant inheritance (HP:0001423)1.66737851
165Poor suck (HP:0002033)1.66421792
166Tubulointerstitial nephritis (HP:0001970)1.66025516
167Astrocytoma (HP:0009592)1.65999521
168Abnormality of the astrocytes (HP:0100707)1.65999521
169Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.65259652
170Decreased activity of mitochondrial respiratory chain (HP:0008972)1.65259652
171Molar tooth sign on MRI (HP:0002419)1.65117947
172Abnormality of midbrain morphology (HP:0002418)1.65117947
173Ectopic kidney (HP:0000086)1.64821945
174Pancreatic cysts (HP:0001737)1.61945302
175Renal hypoplasia (HP:0000089)1.61940565
176Multiple enchondromatosis (HP:0005701)1.61662513
177Neoplasm of the adrenal cortex (HP:0100641)1.61616575
178Aplasia involving forearm bones (HP:0009822)1.61500979

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.65626398
2PBK3.57619349
3WNK33.20159061
4OXSR13.16358616
5STK163.14333338
6BCR3.04175073
7WNK42.79313023
8BCKDK2.77377016
9TRIM282.76925951
10CDC72.58990941
11EPHB12.49038605
12MAP3K42.42167034
13LIMK12.27438860
14MKNK22.27023902
15TTK2.20605477
16MST42.14539485
17MAP2K72.11073436
18NEK12.03884626
19TESK22.00831327
20MAPKAPK51.97426491
21PKN11.94728087
22CSNK1G31.82976203
23TXK1.74305677
24VRK21.64664220
25WEE11.63561089
26NEK61.54820083
27TNIK1.51301845
28MET1.50429937
29CSNK1A1L1.49450686
30WNK11.48455722
31BRSK21.48214586
32TAF11.45834882
33DYRK21.44508585
34TSSK61.43509880
35BMPR21.41634207
36PASK1.40810583
37FGFR21.37895091
38NUAK11.37461909
39BLK1.36682476
40BUB11.36110869
41EIF2AK31.35163670
42PLK11.33783182
43DYRK31.31138564
44IRAK31.30572217
45CSNK1G11.30432376
46SGK2231.22244563
47SGK4941.22244563
48RPS6KA41.20936195
49AKT31.20013149
50EIF2AK11.18192529
51BMPR1B1.17434368
52CAMK2B1.14858963
53CASK1.12334768
54ATR1.12055966
55CDK191.11872556
56CSNK1G21.11045188
57PRPF4B1.10517940
58CHEK21.03544103
59CCNB11.02218318
60ADRBK21.01687480
61GRK70.97899914
62UHMK10.95839674
63ROCK20.94706860
64IRAK40.93326278
65MAP3K100.92835479
66PINK10.91368607
67CLK10.91102280
68ZAK0.89018626
69CAMK2G0.87916287
70TGFBR10.86574021
71VRK10.86014790
72CAMK2D0.85177699
73IRAK20.83460711
74PRKCQ0.81924458
75ATM0.80191537
76MAPK130.79477623
77PLK40.79351486
78MAP4K20.77983506
79FLT30.77410353
80AURKB0.76790554
81ERBB30.76571353
82ERBB40.76237827
83BRSK10.75541504
84RPS6KA50.74716557
85OBSCN0.74591767
86PAK30.73614769
87CDK30.70878395
88BRD40.70856775
89ABL20.70654540
90PRKCE0.68280950
91NEK20.68257711
92PNCK0.67644130
93MAP2K40.66060986
94CHEK10.64899472
95MINK10.62740335
96MKNK10.61930457
97PRKCG0.61280722
98EIF2AK20.61116872
99IRAK10.60848097
100FGR0.60486054
101TRPM70.58774064
102MYLK0.58335993
103MAP3K120.58224141
104EPHB20.57680464
105CSNK2A20.54548254
106GRK10.54531525
107NME20.54463732
108STK30.54306261
109ITK0.54176955
110INSRR0.53675819
111CSNK1E0.53009935
112MARK10.52641034
113SIK30.52615155
114NTRK20.52237539
115PDK20.51917980
116CDK180.51629611
117FRK0.48519896
118CAMK2A0.48433661
119NTRK10.47983498
120CDK70.47937345
121TEC0.46441409
122CDK10.46413370
123CSNK2A10.46270494
124LCK0.45667195
125KSR10.44796859
126EPHA40.44612034
127MAP3K50.44099736
128CDK150.43774100
129PRKDC0.43508066
130PRKG10.43195048
131ALK0.42998089
132CDK20.42546685
133DYRK1B0.42369147
134FGFR10.42322901
135PIK3CG0.41958250
136IKBKB0.41725867
137CDK11A0.41221755
138PLK20.40244677
139MAP3K140.40131081
140NEK90.39759616
141PRKACB0.37097564
142LYN0.36572487
143MAPK150.36404953
144CSNK1A10.36012075
145NME10.35455499
146SRPK10.34184970
147MAPK40.32528800
148PRKACA0.31799345
149CDK140.31773411
150TYK20.31565531
151ERBB20.31491828
152BRAF0.31055717
153FYN0.30517865
154STK40.30181620
155ARAF0.30069802
156BTK0.29827821
157PLK30.29781392
158FGFR40.29034873
159PRKCD0.28879953
160YES10.28486726

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000624.41470614
2Steroid biosynthesis_Homo sapiens_hsa001004.27873438
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.19534431
4Mismatch repair_Homo sapiens_hsa034303.04776916
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.04170829
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.02165225
7DNA replication_Homo sapiens_hsa030302.86523230
8Protein export_Homo sapiens_hsa030602.76377443
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.52346189
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.48847405
11Proteasome_Homo sapiens_hsa030502.45184721
12Base excision repair_Homo sapiens_hsa034102.42417473
13Oxidative phosphorylation_Homo sapiens_hsa001902.36726931
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.26307119
15Fanconi anemia pathway_Homo sapiens_hsa034602.21352334
16Sulfur metabolism_Homo sapiens_hsa009202.17232389
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.15075549
18Nucleotide excision repair_Homo sapiens_hsa034202.10539666
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.07891207
20Peroxisome_Homo sapiens_hsa041462.06568671
21Primary bile acid biosynthesis_Homo sapiens_hsa001202.04661430
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.01493931
23Histidine metabolism_Homo sapiens_hsa003402.00052037
24Spliceosome_Homo sapiens_hsa030401.98115564
25Vitamin B6 metabolism_Homo sapiens_hsa007501.89055858
26RNA transport_Homo sapiens_hsa030131.88548466
27Parkinsons disease_Homo sapiens_hsa050121.86268537
28Butanoate metabolism_Homo sapiens_hsa006501.85420643
29Cell cycle_Homo sapiens_hsa041101.80328965
30One carbon pool by folate_Homo sapiens_hsa006701.78381529
31RNA degradation_Homo sapiens_hsa030181.78271292
32Propanoate metabolism_Homo sapiens_hsa006401.74906580
33Ether lipid metabolism_Homo sapiens_hsa005651.71928637
34Fatty acid metabolism_Homo sapiens_hsa012121.65212664
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.64749277
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.56916912
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.50051500
38RNA polymerase_Homo sapiens_hsa030201.49542534
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.47032506
40Folate biosynthesis_Homo sapiens_hsa007901.46750731
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.31946634
42Alzheimers disease_Homo sapiens_hsa050101.30320852
43Fatty acid degradation_Homo sapiens_hsa000711.28995988
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.27623040
45Arginine and proline metabolism_Homo sapiens_hsa003301.26259787
46Sphingolipid metabolism_Homo sapiens_hsa006001.20821382
47Chemical carcinogenesis_Homo sapiens_hsa052041.19011932
48Tryptophan metabolism_Homo sapiens_hsa003801.18511012
49beta-Alanine metabolism_Homo sapiens_hsa004101.17945190
50Tyrosine metabolism_Homo sapiens_hsa003501.17443921
51Selenocompound metabolism_Homo sapiens_hsa004501.16895406
52Retinol metabolism_Homo sapiens_hsa008301.16460000
53Glutathione metabolism_Homo sapiens_hsa004801.16091518
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.15465076
55Pyruvate metabolism_Homo sapiens_hsa006201.09187265
56Linoleic acid metabolism_Homo sapiens_hsa005911.08102256
57mRNA surveillance pathway_Homo sapiens_hsa030151.07985255
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.06464032
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98289041
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95854793
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94899533
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94392775
63Huntingtons disease_Homo sapiens_hsa050160.93654806
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.93166709
65Metabolic pathways_Homo sapiens_hsa011000.89028858
66Complement and coagulation cascades_Homo sapiens_hsa046100.87934196
67Arachidonic acid metabolism_Homo sapiens_hsa005900.87060265
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85059819
69Nitrogen metabolism_Homo sapiens_hsa009100.83742471
70Phenylalanine metabolism_Homo sapiens_hsa003600.79930178
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.78726093
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77856664
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77698548
74p53 signaling pathway_Homo sapiens_hsa041150.77518435
75Staphylococcus aureus infection_Homo sapiens_hsa051500.75660540
76Collecting duct acid secretion_Homo sapiens_hsa049660.75133005
77Oocyte meiosis_Homo sapiens_hsa041140.72018391
78Nicotine addiction_Homo sapiens_hsa050330.69782266
79Regulation of autophagy_Homo sapiens_hsa041400.67705859
80Basal cell carcinoma_Homo sapiens_hsa052170.67336464
81Arginine biosynthesis_Homo sapiens_hsa002200.66627911
82PPAR signaling pathway_Homo sapiens_hsa033200.66180838
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65852769
84ABC transporters_Homo sapiens_hsa020100.64362776
85Rheumatoid arthritis_Homo sapiens_hsa053230.63449668
86Vitamin digestion and absorption_Homo sapiens_hsa049770.58711270
87Autoimmune thyroid disease_Homo sapiens_hsa053200.57567184
88Alcoholism_Homo sapiens_hsa050340.56898838
89Lysosome_Homo sapiens_hsa041420.56780733
90Carbon metabolism_Homo sapiens_hsa012000.55740025
91Pentose phosphate pathway_Homo sapiens_hsa000300.54772891
92N-Glycan biosynthesis_Homo sapiens_hsa005100.53684386
93Hedgehog signaling pathway_Homo sapiens_hsa043400.52574472
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52256387
95Pyrimidine metabolism_Homo sapiens_hsa002400.50719602
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49225585
97Other glycan degradation_Homo sapiens_hsa005110.48136735
98Cardiac muscle contraction_Homo sapiens_hsa042600.47583983
99Lysine degradation_Homo sapiens_hsa003100.47384683
100Homologous recombination_Homo sapiens_hsa034400.46376021
101Phagosome_Homo sapiens_hsa041450.46247224
102Hippo signaling pathway_Homo sapiens_hsa043900.45745137
103Vibrio cholerae infection_Homo sapiens_hsa051100.44314691
104Ribosome_Homo sapiens_hsa030100.44208471
105Caffeine metabolism_Homo sapiens_hsa002320.43083845
106Biosynthesis of amino acids_Homo sapiens_hsa012300.42787578
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42663113
108Allograft rejection_Homo sapiens_hsa053300.42323006
109Maturity onset diabetes of the young_Homo sapiens_hsa049500.41347419
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39987724
111TGF-beta signaling pathway_Homo sapiens_hsa043500.39606639
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38102410
113Non-homologous end-joining_Homo sapiens_hsa034500.37611789
114Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36897573
115Purine metabolism_Homo sapiens_hsa002300.35387556
116Wnt signaling pathway_Homo sapiens_hsa043100.35293754
117Fatty acid biosynthesis_Homo sapiens_hsa000610.34120910
118Serotonergic synapse_Homo sapiens_hsa047260.33683404
119Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.31889425
120Basal transcription factors_Homo sapiens_hsa030220.31470553
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31368419
122Glycerolipid metabolism_Homo sapiens_hsa005610.30921941
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.30447383
124Sulfur relay system_Homo sapiens_hsa041220.30097496
125Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28562396
126Adherens junction_Homo sapiens_hsa045200.25525864
127Fat digestion and absorption_Homo sapiens_hsa049750.25428393
128Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.24820892
129Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23687829
130Graft-versus-host disease_Homo sapiens_hsa053320.23379592
131Systemic lupus erythematosus_Homo sapiens_hsa053220.23031496
132Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.17986813
133Starch and sucrose metabolism_Homo sapiens_hsa005000.14403458
134Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.08891385
135Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.07952277
136Asthma_Homo sapiens_hsa053100.07268899
137Phototransduction_Homo sapiens_hsa047440.06998537

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