LDB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the LIM-domain binding family. Members of this family are characterized by a conserved nuclear localization sequence, an amino-terminal homodimerization domain and a carboxy-terminal LIM interaction domain. These proteins function as adapter molecules to allow assembly of transcriptional regulatory complexes. Genetic association studies suggest functions for this gene in rhegmatogenous retinal detachment and coronary artery disease. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endothelium development (GO:0003158)5.31041998
2vocalization behavior (GO:0071625)4.87877070
3synaptic vesicle exocytosis (GO:0016079)4.70064701
4protein localization to synapse (GO:0035418)4.68074577
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.59518115
6neuron cell-cell adhesion (GO:0007158)4.58638938
7glutamate secretion (GO:0014047)4.56471622
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.48866638
9lymphangiogenesis (GO:0001946)4.27496193
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.25133828
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.18500938
12regulation of synaptic vesicle exocytosis (GO:2000300)4.13229154
13cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.12100829
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.09316554
15locomotory exploration behavior (GO:0035641)4.06857616
16regulation of glutamate receptor signaling pathway (GO:1900449)4.06401460
17cell communication by electrical coupling (GO:0010644)4.02978840
18neuron recognition (GO:0008038)4.00798104
19exploration behavior (GO:0035640)3.97184754
20synaptic vesicle maturation (GO:0016188)3.96127327
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.89228338
22ionotropic glutamate receptor signaling pathway (GO:0035235)3.77040152
23glutamate receptor signaling pathway (GO:0007215)3.72895741
24regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.72827374
25atrial cardiac muscle cell action potential (GO:0086014)3.72216414
26layer formation in cerebral cortex (GO:0021819)3.71635421
27positive regulation of synaptic transmission, GABAergic (GO:0032230)3.66099149
28regulation of synaptic vesicle transport (GO:1902803)3.63441599
29axonal fasciculation (GO:0007413)3.57705137
30proline transport (GO:0015824)3.49994725
31neuronal action potential propagation (GO:0019227)3.48875122
32negative regulation of dendrite morphogenesis (GO:0050774)3.47972132
33regulation of long-term neuronal synaptic plasticity (GO:0048169)3.47859271
34synaptic transmission, glutamatergic (GO:0035249)3.44933374
35neuron-neuron synaptic transmission (GO:0007270)3.43163015
36innervation (GO:0060384)3.41261005
37neurotransmitter-gated ion channel clustering (GO:0072578)3.40182555
38sodium ion export (GO:0071436)3.36451962
39artery development (GO:0060840)3.34631944
40blood vessel maturation (GO:0001955)3.33675618
41positive regulation of synapse maturation (GO:0090129)3.32162728
42presynaptic membrane assembly (GO:0097105)3.30713801
43postsynaptic membrane organization (GO:0001941)3.28705137
44cell migration in hindbrain (GO:0021535)3.27672429
45regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.27526754
46regulation of neuronal synaptic plasticity (GO:0048168)3.23231727
47long-term synaptic potentiation (GO:0060291)3.23115199
48regulation of excitatory postsynaptic membrane potential (GO:0060079)3.22515714
49gamma-aminobutyric acid signaling pathway (GO:0007214)3.22020226
50response to histamine (GO:0034776)3.21710003
51regulation of postsynaptic membrane potential (GO:0060078)3.19521198
52regulation of axon guidance (GO:1902667)3.19155070
53synaptic vesicle endocytosis (GO:0048488)3.19063498
54regulation of axon extension involved in axon guidance (GO:0048841)3.18972012
55vascular endothelial growth factor signaling pathway (GO:0038084)3.18809689
56neurotransmitter secretion (GO:0007269)3.18491243
57regulation of synapse structural plasticity (GO:0051823)3.16330495
58cell migration involved in sprouting angiogenesis (GO:0002042)3.16316922
59dendritic spine morphogenesis (GO:0060997)3.14882404
60behavioral defense response (GO:0002209)3.12507193
61behavioral fear response (GO:0001662)3.12507193
62retina vasculature morphogenesis in camera-type eye (GO:0061299)3.11638571
63regulation of synaptic transmission, glutamatergic (GO:0051966)3.11203550
64long-term memory (GO:0007616)3.09427123
65negative regulation of synaptic transmission, GABAergic (GO:0032229)3.08379295
66negative regulation of dendrite development (GO:2000171)3.08080623
67activation of protein kinase A activity (GO:0034199)3.05607878
68regulation of dendritic spine morphogenesis (GO:0061001)3.02908357
69G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.99462360
70hyperosmotic salinity response (GO:0042538)2.96769307
71regulation of synaptic plasticity (GO:0048167)2.95854806
72negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.94441480
73cell communication involved in cardiac conduction (GO:0086065)2.94229891
74presynaptic membrane organization (GO:0097090)2.92610657
75positive regulation of neurotransmitter secretion (GO:0001956)2.92362963
76regulation of neurotransmitter secretion (GO:0046928)2.91947509
77fear response (GO:0042596)2.91804096
78regulation of synapse maturation (GO:0090128)2.89378024
79calcium-mediated signaling using intracellular calcium source (GO:0035584)2.88911519
80positive regulation of membrane potential (GO:0045838)2.86880979
81negative regulation of cytosolic calcium ion concentration (GO:0051481)2.85980562
82synapse assembly (GO:0007416)2.85742127
83axon extension (GO:0048675)2.81480069
84positive regulation of synapse assembly (GO:0051965)2.81187060
85membrane depolarization during action potential (GO:0086010)2.80813489
86G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.79663841
87positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.79571580
88neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.79171765
89regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.79004915
90axon extension involved in axon guidance (GO:0048846)2.78450777
91neuron projection extension involved in neuron projection guidance (GO:1902284)2.78450777
92vascular smooth muscle contraction (GO:0014829)2.78265768
93positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.77572789
94membrane depolarization (GO:0051899)2.77295030
95positive regulation of vasculogenesis (GO:2001214)2.77054491
96gamma-aminobutyric acid transport (GO:0015812)2.76838023
97membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.74898038
98regulation of glutamate secretion (GO:0014048)2.73613462
99transmission of nerve impulse (GO:0019226)2.72633303
100positive regulation of dendritic spine development (GO:0060999)2.72423314
101dendrite morphogenesis (GO:0048813)2.72349011
102regulation of synaptic transmission, GABAergic (GO:0032228)2.71294020
103detection of calcium ion (GO:0005513)2.70135051
104positive regulation of synaptic transmission (GO:0050806)2.70032187
105regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.69881144
106regulation of vesicle fusion (GO:0031338)2.68557867
107endothelial cell differentiation (GO:0045446)2.67056865
108positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.66070933
109neurotransmitter transport (GO:0006836)2.65707206
110positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.65562763
111positive regulation of muscle hypertrophy (GO:0014742)2.65399462
112positive regulation of cardiac muscle hypertrophy (GO:0010613)2.65399462
113learning (GO:0007612)2.65260002
114lymph vessel development (GO:0001945)2.64959762
115cochlea development (GO:0090102)2.64793047
116pre-miRNA processing (GO:0031054)2.64412121
117regulation of vasculogenesis (GO:2001212)2.63021631
118dopamine receptor signaling pathway (GO:0007212)2.62929707
119regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.62915594
120regulation of cAMP-dependent protein kinase activity (GO:2000479)2.62798897
121regulation of dendritic spine development (GO:0060998)2.62594233
122synapse organization (GO:0050808)2.62540351
123long term synaptic depression (GO:0060292)2.61577188
124glycosphingolipid biosynthetic process (GO:0006688)2.61498983
125cellular potassium ion homeostasis (GO:0030007)2.61348381
126cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.59806948
127neuron remodeling (GO:0016322)2.59490406
128auditory behavior (GO:0031223)2.58530467
129clathrin coat assembly (GO:0048268)2.57725015
130regulation of protein kinase A signaling (GO:0010738)2.57241207
131regulation of synaptic transmission (GO:0050804)2.56244753
132dendrite development (GO:0016358)2.55776598
133cellular sodium ion homeostasis (GO:0006883)2.55446881
134regulation of neurotransmitter transport (GO:0051588)2.55372523
135peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.52324864
136Notch signaling involved in heart development (GO:0061314)2.51164031
137endothelial tube morphogenesis (GO:0061154)2.46593099
138morphogenesis of an endothelium (GO:0003159)2.46593099
139regulation of mesoderm development (GO:2000380)2.43717370
140positive regulation of cardiac muscle cell differentiation (GO:2000727)2.40629913
141negative regulation of axon guidance (GO:1902668)2.38668131
142limb bud formation (GO:0060174)2.38021378
143regulation of cell communication by electrical coupling (GO:0010649)2.36825440
144embryonic foregut morphogenesis (GO:0048617)2.36620182
145embryonic heart tube development (GO:0035050)2.36482831
146response to auditory stimulus (GO:0010996)2.34677238
147regulation of neuron migration (GO:2001222)2.34269255
148central nervous system projection neuron axonogenesis (GO:0021952)2.32146541
149regulation of endothelial cell differentiation (GO:0045601)2.30801092
150sequestering of extracellular ligand from receptor (GO:0035581)2.30426060
151anterior/posterior axis specification, embryo (GO:0008595)2.27893678
152relaxation of smooth muscle (GO:0044557)2.27591466
153regulation of membrane repolarization (GO:0060306)2.27490861
154sprouting angiogenesis (GO:0002040)2.27327579
155cell migration involved in gastrulation (GO:0042074)2.24699569
156dendritic spine organization (GO:0097061)2.23779421

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.99947922
2* GBX2_23144817_ChIP-Seq_PC3_Human3.45681316
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.21789378
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.14163916
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.05235052
6SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.80339307
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.78081160
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.78081160
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.77636115
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.76766131
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.74715233
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.71276085
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.70094794
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.48076711
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.45302992
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.31919606
17TAF15_26573619_Chip-Seq_HEK293_Human2.28027384
18* REST_21632747_ChIP-Seq_MESCs_Mouse2.15832068
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.15280285
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.14711949
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.12057748
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.11553238
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.06004194
24AR_21572438_ChIP-Seq_LNCaP_Human2.02753187
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92921979
26BMI1_23680149_ChIP-Seq_NPCS_Mouse1.89053875
27P300_19829295_ChIP-Seq_ESCs_Human1.87041448
28PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.84581080
29* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83310881
30* SMAD4_21799915_ChIP-Seq_A2780_Human1.83210911
31DROSHA_22980978_ChIP-Seq_HELA_Human1.78488390
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.78406818
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.75975218
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75872520
35RBPJ_22232070_ChIP-Seq_NCS_Mouse1.69273946
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.69252074
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67051979
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.66544319
39RARB_27405468_Chip-Seq_BRAIN_Mouse1.63706423
40RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.63201971
41* CBX2_27304074_Chip-Seq_ESCs_Mouse1.62586398
42TOP2B_26459242_ChIP-Seq_MCF-7_Human1.59630308
43* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.56463037
44VDR_22108803_ChIP-Seq_LS180_Human1.56258762
45ZNF274_21170338_ChIP-Seq_K562_Hela1.54376317
46FUS_26573619_Chip-Seq_HEK293_Human1.53502100
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.53282145
48NR3C1_23031785_ChIP-Seq_PC12_Mouse1.50134704
49* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46993375
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.46305620
51SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45035736
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44089160
53TRIM28_21343339_ChIP-Seq_HEK293_Human1.42660519
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39889405
55AR_25329375_ChIP-Seq_VCAP_Human1.37046836
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.36916862
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.36797816
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36166113
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34776497
60* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34279067
61CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.34270221
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33665191
63RNF2_27304074_Chip-Seq_NSC_Mouse1.30112617
64RING1B_27294783_Chip-Seq_ESCs_Mouse1.29959765
65TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.27103598
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26801364
67SMAD3_21741376_ChIP-Seq_HESCs_Human1.25622994
68* SOX2_21211035_ChIP-Seq_LN229_Gbm1.25590866
69ERG_21242973_ChIP-ChIP_JURKAT_Human1.24366252
70PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.23226968
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22684712
72KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.22588244
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.22187628
74AHR_22903824_ChIP-Seq_MCF-7_Human1.21870971
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21652812
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21347595
77BCAT_22108803_ChIP-Seq_LS180_Human1.21311938
78NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20597840
79NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20597840
80TBX3_20139965_ChIP-Seq_MESCs_Mouse1.20073444
81STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.19204537
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18537426
83TBX3_20139965_ChIP-Seq_ESCs_Mouse1.18376488
84ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17631181
85* STAT3_23295773_ChIP-Seq_U87_Human1.17390475
86JUN_21703547_ChIP-Seq_K562_Human1.17167375
87EWS_26573619_Chip-Seq_HEK293_Human1.16543672
88ISL1_27105846_Chip-Seq_CPCs_Mouse1.15015824
89TP53_18474530_ChIP-ChIP_U2OS_Human1.14697116
90HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.13619139
91IGF1R_20145208_ChIP-Seq_DFB_Human1.13229508
92* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11896916
93MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11843345
94RING1B_27294783_Chip-Seq_NPCs_Mouse1.11615899
95RUNX2_22187159_ChIP-Seq_PCA_Human1.11437403
96EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09503644
97EP300_21415370_ChIP-Seq_HL-1_Mouse1.09421745
98* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09388716
99P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08377173
100PRDM14_20953172_ChIP-Seq_ESCs_Human1.08086293
101SOX9_26525672_Chip-Seq_HEART_Mouse1.07971531
102* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07855797
103NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07543796
104* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07281476
105* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07196690
106* AR_19668381_ChIP-Seq_PC3_Human1.04811754
107WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04708612
108WT1_19549856_ChIP-ChIP_CCG9911_Human1.02145916
109ER_23166858_ChIP-Seq_MCF-7_Human1.02084856
110* TCF4_23295773_ChIP-Seq_U87_Human1.02084647
111PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00494958
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99727499
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99727499
114* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97668507
115* SMAD4_21741376_ChIP-Seq_HESCs_Human0.97558736
116SMAD3_21741376_ChIP-Seq_ESCs_Human0.94829439
117TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94277386
118WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91950225
119KDM2B_26808549_Chip-Seq_REH_Human0.90672097
120TP53_16413492_ChIP-PET_HCT116_Human0.90489109
121TP53_20018659_ChIP-ChIP_R1E_Mouse0.90424367
122NANOG_18555785_Chip-Seq_ESCs_Mouse0.90025296

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.79800863
2MP0003880_abnormal_central_pattern4.64985681
3MP0001968_abnormal_touch/_nociception4.27142473
4MP0002736_abnormal_nociception_after3.83634438
5MP0003635_abnormal_synaptic_transmissio3.41815267
6MP0002735_abnormal_chemical_nociception3.40155688
7MP0004270_analgesia3.36586736
8MP0002063_abnormal_learning/memory/cond2.84257716
9MP0002734_abnormal_mechanical_nocicepti2.82431414
10MP0006276_abnormal_autonomic_nervous2.78625586
11MP0009745_abnormal_behavioral_response2.76026886
12MP0003122_maternal_imprinting2.65955470
13MP0003890_abnormal_embryonic-extraembry2.51121963
14MP0002572_abnormal_emotion/affect_behav2.46720102
15MP0002064_seizures2.46002844
16MP0010368_abnormal_lymphatic_system2.25578174
17MP0002733_abnormal_thermal_nociception2.25265893
18MP0001440_abnormal_grooming_behavior2.24829473
19MP0001970_abnormal_pain_threshold2.16616308
20MP0006054_spinal_hemorrhage2.12292755
21MP0002272_abnormal_nervous_system2.10512173
22MP0004858_abnormal_nervous_system2.05025275
23MP0009046_muscle_twitch2.00263181
24MP0000778_abnormal_nervous_system1.99659434
25MP0002184_abnormal_innervation1.98893599
26MP0002067_abnormal_sensory_capabilities1.93328805
27MP0001486_abnormal_startle_reflex1.93200165
28MP0001188_hyperpigmentation1.85973303
29MP0001501_abnormal_sleep_pattern1.83818173
30MP0004084_abnormal_cardiac_muscle1.83622227
31MP0001879_abnormal_lymphatic_vessel1.74839382
32MP0005423_abnormal_somatic_nervous1.68343272
33MP0004133_heterotaxia1.65002398
34MP0002837_dystrophic_cardiac_calcinosis1.64872961
35MP0009780_abnormal_chondrocyte_physiolo1.59975453
36MP0008438_abnormal_cutaneous_collagen1.59843032
37MP0002557_abnormal_social/conspecific_i1.51267251
38MP0005275_abnormal_skin_tensile1.48765688
39MP0005167_abnormal_blood-brain_barrier1.47649168
40MP0004924_abnormal_behavior1.46546734
41MP0005386_behavior/neurological_phenoty1.46546734
42MP0003283_abnormal_digestive_organ1.42008138
43MP0003119_abnormal_digestive_system1.41461553
44MP0002295_abnormal_pulmonary_circulatio1.39634983
45MP0004272_abnormal_basement_membrane1.38980800
46MP0004811_abnormal_neuron_physiology1.38491141
47MP0010386_abnormal_urinary_bladder1.36129168
48MP0000751_myopathy1.35580887
49MP0004484_altered_response_of1.35468887
50MP0001299_abnormal_eye_distance/1.31763679
51MP0003329_amyloid_beta_deposits1.31054467
52MP0003279_aneurysm1.29421590
53MP0010030_abnormal_orbit_morphology1.29346326
54MP0001984_abnormal_olfaction1.28440324
55MP0001905_abnormal_dopamine_level1.27162833
56MP0001529_abnormal_vocalization1.25176938
57MP0003941_abnormal_skin_development1.24324501
58MP0002882_abnormal_neuron_morphology1.21634159
59MP0004145_abnormal_muscle_electrophysio1.21438756
60MP0000767_abnormal_smooth_muscle1.21270365
61MP0000955_abnormal_spinal_cord1.19451513
62MP0001502_abnormal_circadian_rhythm1.17383146
63MP0004085_abnormal_heartbeat1.15291565
64MP0002909_abnormal_adrenal_gland1.12333618
65MP0000049_abnormal_middle_ear1.11998534
66MP0002066_abnormal_motor_capabilities/c1.10352637
67MP0005187_abnormal_penis_morphology1.08184812
68MP0003787_abnormal_imprinting1.06911975
69MP0004215_abnormal_myocardial_fiber1.06831787
70MP0005409_darkened_coat_color1.06771666
71MP0000013_abnormal_adipose_tissue1.06243311
72MP0003879_abnormal_hair_cell1.06173007
73MP0002102_abnormal_ear_morphology1.04860125
74MP0003137_abnormal_impulse_conducting1.04468669
75MP0008004_abnormal_stomach_pH1.04456094
76MP0005623_abnormal_meninges_morphology1.04016871
77MP0002822_catalepsy1.03570088
78MP0008569_lethality_at_weaning0.99417583
79MP0003633_abnormal_nervous_system0.97284297
80MP0003121_genomic_imprinting0.93759123
81MP0005595_abnormal_vascular_smooth0.93024959
82MP0003937_abnormal_limbs/digits/tail_de0.92210651
83MP0005171_absent_coat_pigmentation0.91846156
84MP0002152_abnormal_brain_morphology0.90651635
85MP0003385_abnormal_body_wall0.90491124
86MP0005646_abnormal_pituitary_gland0.89662409
87MP0002127_abnormal_cardiovascular_syste0.87844556
88MP0000534_abnormal_ureter_morphology0.85197464
89MP0003631_nervous_system_phenotype0.83117445
90MP0008874_decreased_physiological_sensi0.79000463
91MP0004130_abnormal_muscle_cell0.78653169
92MP0001544_abnormal_cardiovascular_syste0.78648700
93MP0005385_cardiovascular_system_phenoty0.78648700
94MP0000749_muscle_degeneration0.78368450
95MP0002752_abnormal_somatic_nervous0.77895405
96MP0000537_abnormal_urethra_morphology0.76937492
97MP0000428_abnormal_craniofacial_morphol0.76417073
98MP0005551_abnormal_eye_electrophysiolog0.75851058
99MP0009379_abnormal_foot_pigmentation0.75481029
100MP0005670_abnormal_white_adipose0.74175167
101MP0002925_abnormal_cardiovascular_devel0.74001609
102MP0003935_abnormal_craniofacial_develop0.73659889
103MP0004883_abnormal_blood_vessel0.73559567
104MP0001664_abnormal_digestion0.73229781
105MP0001958_emphysema0.73093237
106MP0001485_abnormal_pinna_reflex0.72262496
107MP0003705_abnormal_hypodermis_morpholog0.71496322
108MP0002972_abnormal_cardiac_muscle0.71361180
109MP0002108_abnormal_muscle_morphology0.71078298
110MP0001293_anophthalmia0.70841949
111MP0001963_abnormal_hearing_physiology0.70167196
112MP0002128_abnormal_blood_circulation0.70146878
113MP0002069_abnormal_eating/drinking_beha0.69416912
114MP0002233_abnormal_nose_morphology0.69070625
115MP0005388_respiratory_system_phenotype0.69016457
116MP0002133_abnormal_respiratory_system0.69016457
117MP0004885_abnormal_endolymph0.68732848
118MP0002751_abnormal_autonomic_nervous0.65394659
119MP0002876_abnormal_thyroid_physiology0.64915453
120MP0004742_abnormal_vestibular_system0.64737852
121MP0006138_congestive_heart_failure0.64490960
122MP0001986_abnormal_taste_sensitivity0.63570779
123MP0001177_atelectasis0.63368044
124MP0005535_abnormal_body_temperature0.61564561
125MP0003123_paternal_imprinting0.61308551
126MP0001943_abnormal_respiration0.60954849
127MP0002638_abnormal_pupillary_reflex0.60889354
128MP0005620_abnormal_muscle_contractility0.60292342
129MP0005645_abnormal_hypothalamus_physiol0.60217240
130MP0000230_abnormal_systemic_arterial0.59068874
131MP0005503_abnormal_tendon_morphology0.58619571
132MP0003942_abnormal_urinary_system0.58044808
133MP0004142_abnormal_muscle_tone0.57620801
134MP0003861_abnormal_nervous_system0.55858320
135MP0004036_abnormal_muscle_relaxation0.55546129
136MP0000631_abnormal_neuroendocrine_gland0.54880415
137MP0008872_abnormal_physiological_respon0.54624577
138MP0009250_abnormal_appendicular_skeleto0.54436844

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.36359104
2Myokymia (HP:0002411)5.72874522
3Focal seizures (HP:0007359)4.86698547
4Atonic seizures (HP:0010819)4.76521900
5Epileptic encephalopathy (HP:0200134)4.57422095
6Febrile seizures (HP:0002373)4.06630816
7Visual hallucinations (HP:0002367)3.95485450
8Hyperventilation (HP:0002883)3.82992041
9Absence seizures (HP:0002121)3.81385150
10Muscle fiber splitting (HP:0003555)3.72398289
11Progressive cerebellar ataxia (HP:0002073)3.55885908
12Termporal pattern (HP:0011008)3.44095374
13Insidious onset (HP:0003587)3.44095374
14Dialeptic seizures (HP:0011146)3.38194366
15Amblyopia (HP:0000646)3.34452562
16Broad-based gait (HP:0002136)3.20365166
17Generalized tonic-clonic seizures (HP:0002069)3.19935661
18Action tremor (HP:0002345)3.08475037
19Hip contracture (HP:0003273)3.04987984
20Difficulty running (HP:0009046)2.92314607
21Polyphagia (HP:0002591)2.82106644
22Limited hip movement (HP:0008800)2.79301987
23Abnormal eating behavior (HP:0100738)2.68113184
24Pheochromocytoma (HP:0002666)2.67305955
25Excessive salivation (HP:0003781)2.63792950
26Drooling (HP:0002307)2.63792950
27Impaired vibration sensation in the lower limbs (HP:0002166)2.60974339
28Supranuclear gaze palsy (HP:0000605)2.60795482
29Anxiety (HP:0000739)2.57011523
30Truncal ataxia (HP:0002078)2.55746361
31Cerebral inclusion bodies (HP:0100314)2.53753154
32Spinal muscular atrophy (HP:0007269)2.53610537
33Abnormality of the middle phalanges of the toes (HP:0010183)2.47195552
34Hypoventilation (HP:0002791)2.46134820
35Gait imbalance (HP:0002141)2.44839430
36Short tibia (HP:0005736)2.43927215
37Depression (HP:0000716)2.43462919
38Septo-optic dysplasia (HP:0100842)2.40849068
39Cortical dysplasia (HP:0002539)2.37973637
40Abnormality of pain sensation (HP:0010832)2.36224957
41Impaired pain sensation (HP:0007328)2.36224957
42Poor eye contact (HP:0000817)2.34125985
43Neuroendocrine neoplasm (HP:0100634)2.34115333
44Limb dystonia (HP:0002451)2.33748835
45Aplasia/Hypoplasia of the tibia (HP:0005772)2.32333470
46Abnormal hair whorl (HP:0010721)2.31958578
47Epileptiform EEG discharges (HP:0011182)2.28124057
48Ankle clonus (HP:0011448)2.26851633
49Urinary bladder sphincter dysfunction (HP:0002839)2.25704433
50Absent speech (HP:0001344)2.25173980
51Gaze-evoked nystagmus (HP:0000640)2.23955004
52Abnormality of the corticospinal tract (HP:0002492)2.23646296
53Fetal akinesia sequence (HP:0001989)2.23071481
54Lymphangioma (HP:0100764)2.22839738
55Abnormal ciliary motility (HP:0012262)2.22406005
56Cerebral hemorrhage (HP:0001342)2.20864834
57Aortic aneurysm (HP:0004942)2.19740319
58Heterochromia iridis (HP:0001100)2.16403161
59Broad metatarsal (HP:0001783)2.14812851
60Urinary urgency (HP:0000012)2.14003861
61Myotonia (HP:0002486)2.12466310
62Mutism (HP:0002300)2.11100381
63Hydroureter (HP:0000072)2.10717655
64EEG with generalized epileptiform discharges (HP:0011198)2.09836967
65Hip dysplasia (HP:0001385)2.09722905
66Abnormality of binocular vision (HP:0011514)2.08687632
67Diplopia (HP:0000651)2.08687632
68Exotropia (HP:0000577)2.07688206
69Neurofibrillary tangles (HP:0002185)2.07621925
70Aplasia of the musculature (HP:0100854)2.07579893
71Inability to walk (HP:0002540)2.06046698
72Hemiparesis (HP:0001269)2.05628980
73Hemiplegia (HP:0002301)2.04770822
74Limb-girdle muscle atrophy (HP:0003797)2.04593377
75Dysmetria (HP:0001310)2.03684383
76Blue irides (HP:0000635)2.02637415
77Incomplete penetrance (HP:0003829)2.01970114
78Abnormality of the lower motor neuron (HP:0002366)2.00390276
79Megalencephaly (HP:0001355)1.98650890
80Agitation (HP:0000713)1.97997178
81Abnormal respiratory motile cilium physiology (HP:0012261)1.97591624
82Hematochezia (HP:0002573)1.95937427
83Impaired social interactions (HP:0000735)1.95915339
84Abnormal social behavior (HP:0012433)1.95915339
85Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.95703605
86Congenital primary aphakia (HP:0007707)1.95682650
87Aplasia involving bones of the upper limbs (HP:0009823)1.95581094
88Aplasia of the phalanges of the hand (HP:0009802)1.95581094
89Aplasia involving bones of the extremities (HP:0009825)1.95581094
90Cutaneous finger syndactyly (HP:0010554)1.95329379
91Torticollis (HP:0000473)1.94664556
92Hepatoblastoma (HP:0002884)1.94554566
93Medial flaring of the eyebrow (HP:0010747)1.94445282
94Delusions (HP:0000746)1.94038332
95Abnormality of the calf musculature (HP:0001430)1.93733121
96Atrioventricular block (HP:0001678)1.93648958
97Progressive inability to walk (HP:0002505)1.92981010
98Genital tract atresia (HP:0001827)1.92897564
99Atrial fibrillation (HP:0005110)1.92193191
100Hand muscle atrophy (HP:0009130)1.90383398
101Hammertoe (HP:0001765)1.89966793
102Protruding tongue (HP:0010808)1.88621745
103Cutaneous syndactyly (HP:0012725)1.88567627
104Vaginal atresia (HP:0000148)1.87939097
105Scanning speech (HP:0002168)1.87910229
106Vascular tortuosity (HP:0004948)1.87229526
107Dysdiadochokinesis (HP:0002075)1.86853991
108Hypsarrhythmia (HP:0002521)1.86612675
109Genetic anticipation (HP:0003743)1.85592649
110Hyperthyroidism (HP:0000836)1.85012118
111Acute necrotizing encephalopathy (HP:0006965)1.84754735
112Asymmetry of the thorax (HP:0001555)1.84611981
113Abnormality of the labia minora (HP:0012880)1.84595252
114Focal dystonia (HP:0004373)1.84020027
115Craniofacial dystonia (HP:0012179)1.83678367
116Narrow nasal bridge (HP:0000446)1.83132957
117Adactyly (HP:0009776)1.82357062
118Rapidly progressive (HP:0003678)1.81807710
119Sleep apnea (HP:0010535)1.81668806
120Abnormality of salivation (HP:0100755)1.81532683
121Preaxial foot polydactyly (HP:0001841)1.81172078
122Aplasia/Hypoplasia of the brainstem (HP:0007362)1.80552178
123Hypoplasia of the brainstem (HP:0002365)1.80552178
124Failure to thrive in infancy (HP:0001531)1.80040077
125Lower limb asymmetry (HP:0100559)1.79677746
126Absent eyebrow (HP:0002223)1.79529930
127Ulnar claw (HP:0001178)1.79376307
128Lower limb muscle weakness (HP:0007340)1.79365523
129Optic nerve hypoplasia (HP:0000609)1.79277050
130Obstructive sleep apnea (HP:0002870)1.77485417
131Amyotrophic lateral sclerosis (HP:0007354)1.77426064
132Progressive macrocephaly (HP:0004481)1.77233593
133Wrist flexion contracture (HP:0001239)1.76703400
134Absent/shortened dynein arms (HP:0200106)1.76527153
135Dynein arm defect of respiratory motile cilia (HP:0012255)1.76527153
136Neoplasm of the peripheral nervous system (HP:0100007)1.75937549
137Supraventricular arrhythmia (HP:0005115)1.75835587
138Prominent supraorbital ridges (HP:0000336)1.74297360
139Abnormal respiratory epithelium morphology (HP:0012253)1.74051083
140Short hallux (HP:0010109)1.72714581
141Carpal bone hypoplasia (HP:0001498)1.72062793
142Aplasia/Hypoplasia of the hallux (HP:0008362)1.71923721
143Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.71515075
144Primary atrial arrhythmia (HP:0001692)1.70998449
145Arterial tortuosity (HP:0005116)1.70416832
146Heart block (HP:0012722)1.67934821
147Shawl scrotum (HP:0000049)1.66220443
148Skull defect (HP:0001362)1.66092589
149Knee flexion contracture (HP:0006380)1.65917041
150Abnormality of the vocal cords (HP:0008777)1.62957742
151Shallow orbits (HP:0000586)1.62414434
152Visceral angiomatosis (HP:0100761)1.62250731
153Abnormality of the shoulder girdle musculature (HP:0001435)1.61581635
154Stridor (HP:0010307)1.61388425
155Proximal amyotrophy (HP:0007126)1.61256829
156Absent septum pellucidum (HP:0001331)1.61102953
157Coronal craniosynostosis (HP:0004440)1.59713051
158Supernumerary spleens (HP:0009799)1.59392626
159Overgrowth (HP:0001548)1.58616576
160Supraventricular tachycardia (HP:0004755)1.57741433
161Abdominal situs inversus (HP:0003363)1.56864493
162Abnormality of abdominal situs (HP:0011620)1.56864493
163Mild short stature (HP:0003502)1.56712084
164Midline defect of the nose (HP:0004122)1.56573342
165Absent toe (HP:0010760)1.56014511
166Scapular winging (HP:0003691)1.55723239
167Short 4th metacarpal (HP:0010044)1.55682856

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.55894452
2MAP3K123.47407908
3CASK3.44197208
4TIE13.13606056
5EPHA43.10656600
6MARK12.97166641
7MAP3K92.75421100
8MAP3K42.73513124
9MINK12.50144815
10MAP2K72.45736919
11DAPK22.45485478
12GRK52.36373628
13PNCK2.35247769
14PLK22.18550580
15RIPK42.18374350
16MAP2K42.16675335
17PTK2B1.98292120
18LATS21.95803977
19PINK11.78297775
20WNK31.77102053
21MAPK131.67656255
22NTRK11.66509549
23DAPK11.65523530
24KSR21.60475960
25KDR1.60273837
26MKNK21.54261819
27NTRK21.51082405
28AKT31.51035110
29ARAF1.33417374
30FER1.30270421
31PAK61.29251812
32KSR11.28171138
33CDK51.28011911
34EPHB21.22610222
35SIK21.15252354
36PRKCG1.15020817
37SIK31.14997547
38NME11.13627911
39CDK191.12638960
40CAMK2A1.04681738
41TNIK1.00244751
42CSNK1G10.99426975
43MYLK0.99224109
44PRKD30.98818368
45MKNK10.98047156
46PHKG10.97362936
47PHKG20.97362936
48TGFBR20.97211948
49FES0.95680273
50BMPR20.94631010
51ACVR1B0.93068324
52MAP3K20.88987810
53MAPK120.88001645
54CDK140.85466658
55PDGFRA0.85103616
56INSRR0.83927805
57RET0.83576534
58PLK30.83262020
59NLK0.82788816
60PRKCE0.81647630
61UHMK10.80369506
62DYRK1A0.79907923
63FGFR20.77474251
64FGR0.76749822
65OXSR10.76029603
66SGK4940.74960556
67SGK2230.74960556
68DMPK0.74655590
69ADRBK10.72483159
70CDK180.72467736
71CAMK2B0.70860378
72SGK20.70699232
73BCR0.69438609
74ERBB40.66872888
75OBSCN0.66611574
76TRIM280.65980064
77CSNK1G30.65850415
78STK390.65844072
79CDK150.65040489
80STK110.64286603
81CSNK1G20.62987142
82ADRBK20.62808831
83DDR20.61250345
84TSSK60.60145375
85PAK20.58615781
86MAP2K10.58024913
87MAP3K60.57721427
88ROCK20.56183311
89CAMKK10.55543827
90PRPF4B0.54413882
91CDK11A0.54049657
92LIMK10.52270893
93ERBB30.52134603
94PRKCZ0.51982461
95TGFBR10.50267920
96PAK30.49837152
97RAF10.49659508
98PLK40.48939361
99MAP4K20.47229984
100PRKG10.47172487
101SGK10.46708240
102TAF10.46197311
103TYRO30.44702458
104STK380.44675514
105PRKG20.44261982
106DYRK20.43643904
107MAP3K10.43567770
108CCNB10.43429078
109BRAF0.42454908
110GRK70.41798078
111RIPK10.41712252
112BMPR1B0.41540995
113CAMK10.40371866
114RPS6KA20.39388438
115PRKCH0.38504870
116CAMK2G0.38271414
117LMTK20.37209637
118CAMK2D0.36778911
119CAMK1G0.36175603
120SGK30.35516332
121CDK30.34991625
122PRKD10.34889915
123GRK10.34780470
124PTK20.34722876
125PKN10.34647746
126MARK20.34140997
127DAPK30.34081431
128CSNK1A1L0.33390250
129RPS6KA30.33353198
130CLK10.33171800
131ROCK10.32912352
132CAMKK20.32573219
133ALK0.32081932
134STK38L0.32040539
135LATS10.31094678

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.50995567
2Synaptic vesicle cycle_Homo sapiens_hsa047213.07002418
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.59453609
4Long-term potentiation_Homo sapiens_hsa047202.45432999
5Circadian entrainment_Homo sapiens_hsa047132.44618761
6Glutamatergic synapse_Homo sapiens_hsa047242.36031781
7Olfactory transduction_Homo sapiens_hsa047402.33225555
8Morphine addiction_Homo sapiens_hsa050322.31463310
9GABAergic synapse_Homo sapiens_hsa047272.30526247
10Amphetamine addiction_Homo sapiens_hsa050312.19253322
11Collecting duct acid secretion_Homo sapiens_hsa049662.07111099
12Salivary secretion_Homo sapiens_hsa049702.05194168
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.05167699
14Dopaminergic synapse_Homo sapiens_hsa047282.04518975
15Renin secretion_Homo sapiens_hsa049242.04118025
16Taste transduction_Homo sapiens_hsa047421.91303859
17Insulin secretion_Homo sapiens_hsa049111.82289057
18Serotonergic synapse_Homo sapiens_hsa047261.75265140
19Gastric acid secretion_Homo sapiens_hsa049711.72194988
20Long-term depression_Homo sapiens_hsa047301.70694188
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.67434584
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.65905851
23Cholinergic synapse_Homo sapiens_hsa047251.62795180
24Oxidative phosphorylation_Homo sapiens_hsa001901.60090500
25Calcium signaling pathway_Homo sapiens_hsa040201.58093273
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.54492927
27Gap junction_Homo sapiens_hsa045401.53023149
28Oxytocin signaling pathway_Homo sapiens_hsa049211.52447802
29Axon guidance_Homo sapiens_hsa043601.49867158
30GnRH signaling pathway_Homo sapiens_hsa049121.42692282
31Vibrio cholerae infection_Homo sapiens_hsa051101.38926829
32Cardiac muscle contraction_Homo sapiens_hsa042601.37921811
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.36518279
34ECM-receptor interaction_Homo sapiens_hsa045121.36096273
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.34532071
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33921354
37Alzheimers disease_Homo sapiens_hsa050101.32581319
38Melanogenesis_Homo sapiens_hsa049161.30285925
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.26683635
40Cocaine addiction_Homo sapiens_hsa050301.24178881
41Parkinsons disease_Homo sapiens_hsa050121.22361882
42Propanoate metabolism_Homo sapiens_hsa006401.16985360
43Estrogen signaling pathway_Homo sapiens_hsa049151.16960844
44Vascular smooth muscle contraction_Homo sapiens_hsa042701.15456520
45cAMP signaling pathway_Homo sapiens_hsa040241.13557535
46Basal cell carcinoma_Homo sapiens_hsa052171.13238407
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12324342
48Phototransduction_Homo sapiens_hsa047441.12133886
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.09070378
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.08086325
51Adherens junction_Homo sapiens_hsa045201.05748579
52Hippo signaling pathway_Homo sapiens_hsa043901.04941115
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.04794364
54Glioma_Homo sapiens_hsa052141.04586895
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.03484733
56TGF-beta signaling pathway_Homo sapiens_hsa043501.00443832
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00222175
58Huntingtons disease_Homo sapiens_hsa050160.97617000
59Protein digestion and absorption_Homo sapiens_hsa049740.93338523
60Oocyte meiosis_Homo sapiens_hsa041140.89978696
61Dilated cardiomyopathy_Homo sapiens_hsa054140.86956139
62Histidine metabolism_Homo sapiens_hsa003400.84009417
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83575976
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82855737
65Vitamin B6 metabolism_Homo sapiens_hsa007500.82465178
66Rap1 signaling pathway_Homo sapiens_hsa040150.82081620
67ErbB signaling pathway_Homo sapiens_hsa040120.81142255
68Dorso-ventral axis formation_Homo sapiens_hsa043200.78484030
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78224056
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76036011
71African trypanosomiasis_Homo sapiens_hsa051430.75990777
72VEGF signaling pathway_Homo sapiens_hsa043700.75543251
73Ras signaling pathway_Homo sapiens_hsa040140.75045813
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73938197
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73343634
76Thyroid hormone synthesis_Homo sapiens_hsa049180.73079025
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72339853
78Pancreatic secretion_Homo sapiens_hsa049720.71838694
79Butanoate metabolism_Homo sapiens_hsa006500.69985820
80beta-Alanine metabolism_Homo sapiens_hsa004100.68080113
81MAPK signaling pathway_Homo sapiens_hsa040100.67175718
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.65491933
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65074140
84Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65018726
85Choline metabolism in cancer_Homo sapiens_hsa052310.64592312
86Arginine and proline metabolism_Homo sapiens_hsa003300.64363348
87Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64362269
88Type II diabetes mellitus_Homo sapiens_hsa049300.62285762
89Arginine biosynthesis_Homo sapiens_hsa002200.61557056
90Pyruvate metabolism_Homo sapiens_hsa006200.61372117
91Tryptophan metabolism_Homo sapiens_hsa003800.60343922
92Regulation of autophagy_Homo sapiens_hsa041400.60040965
93Protein export_Homo sapiens_hsa030600.60026331
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58848253
95Wnt signaling pathway_Homo sapiens_hsa043100.57341539
96Steroid biosynthesis_Homo sapiens_hsa001000.56416811
97Rheumatoid arthritis_Homo sapiens_hsa053230.52853524
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52540608
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52244871
100Renal cell carcinoma_Homo sapiens_hsa052110.51650747
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51646053
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51086745
103Glucagon signaling pathway_Homo sapiens_hsa049220.50917318
104Fatty acid degradation_Homo sapiens_hsa000710.49733979
105Ovarian steroidogenesis_Homo sapiens_hsa049130.48623616
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48123097
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.46779393
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46448682
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45800533
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.45641068
111Melanoma_Homo sapiens_hsa052180.43769939
112Hedgehog signaling pathway_Homo sapiens_hsa043400.42978335
113Proteoglycans in cancer_Homo sapiens_hsa052050.42780978
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42455096
115Prion diseases_Homo sapiens_hsa050200.40591081
116Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39260467
117PPAR signaling pathway_Homo sapiens_hsa033200.38669218
118Phagosome_Homo sapiens_hsa041450.38160640
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37431609
120Circadian rhythm_Homo sapiens_hsa047100.36158846
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36053044
122Bile secretion_Homo sapiens_hsa049760.35807904
123Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35430914
124Fatty acid metabolism_Homo sapiens_hsa012120.34391033
125Endometrial cancer_Homo sapiens_hsa052130.34177464
126AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.33834401
127Alcoholism_Homo sapiens_hsa050340.33064085
128Focal adhesion_Homo sapiens_hsa045100.32192097
129Insulin signaling pathway_Homo sapiens_hsa049100.31582633
130Endocytosis_Homo sapiens_hsa041440.30674804
131Tight junction_Homo sapiens_hsa045300.30108029
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29649134
133Colorectal cancer_Homo sapiens_hsa052100.28507423
134Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28258210

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