LDHAL6B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.40692570
2epithelial cilium movement (GO:0003351)9.37890188
3motile cilium assembly (GO:0044458)9.34750561
4male meiosis (GO:0007140)9.13923867
5reproduction (GO:0000003)8.96018750
6synaptonemal complex organization (GO:0070193)8.55166101
7synaptonemal complex assembly (GO:0007130)8.19215772
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.13254437
9cilium movement (GO:0003341)7.95792912
10regulation of cilium movement (GO:0003352)7.74101819
11single fertilization (GO:0007338)7.30676934
12positive regulation of protein deacetylation (GO:0090312)6.79702373
13DNA methylation involved in gamete generation (GO:0043046)6.66676634
14negative regulation of inclusion body assembly (GO:0090084)6.65195288
15fertilization (GO:0009566)6.41183134
16sperm capacitation (GO:0048240)6.34833688
17spermatogenesis (GO:0007283)6.31972660
18male gamete generation (GO:0048232)6.29796204
19male meiosis I (GO:0007141)6.11963084
20gamete generation (GO:0007276)5.78612651
21chromosome organization involved in meiosis (GO:0070192)5.77601118
22negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)5.77417568
23positive regulation of synaptic transmission, dopaminergic (GO:0032226)5.53506365
24organic cation transport (GO:0015695)5.52201798
25microtubule depolymerization (GO:0007019)5.51735210
26germ cell development (GO:0007281)5.41724636
27cellular process involved in reproduction in multicellular organism (GO:0022412)5.41627748
28regulation of inclusion body assembly (GO:0090083)5.36706918
29meiotic nuclear division (GO:0007126)5.30738858
30seminiferous tubule development (GO:0072520)5.17697093
31ventricular system development (GO:0021591)5.15150242
32meiosis I (GO:0007127)4.95140109
33calcium ion-dependent exocytosis (GO:0017156)4.88558894
34cell recognition (GO:0008037)4.88016978
35sister chromatid cohesion (GO:0007062)4.79353660
36interkinetic nuclear migration (GO:0022027)4.68335497
37regulation of microtubule-based movement (GO:0060632)4.58518292
38positive regulation of histone deacetylation (GO:0031065)4.56533444
39multicellular organismal reproductive process (GO:0048609)4.53077520
40microtubule severing (GO:0051013)4.51831428
41reciprocal DNA recombination (GO:0035825)4.46169325
42reciprocal meiotic recombination (GO:0007131)4.46169325
43histone H3-K36 demethylation (GO:0070544)4.43369104
44meiotic cell cycle (GO:0051321)4.36336053
45protein localization to cilium (GO:0061512)4.27944840
46positive regulation of catecholamine secretion (GO:0033605)4.27763678
47histone H3-K9 demethylation (GO:0033169)4.21559110
48response to misfolded protein (GO:0051788)4.20374076
49left/right pattern formation (GO:0060972)4.12285404
50resolution of meiotic recombination intermediates (GO:0000712)4.10950816
51chaperone-mediated protein complex assembly (GO:0051131)4.07261212
52regulation of phosphoprotein phosphatase activity (GO:0043666)4.03501293
53genitalia morphogenesis (GO:0035112)4.01618960
54chromosome condensation (GO:0030261)4.00975904
55glycerol ether metabolic process (GO:0006662)4.00087515
56monoubiquitinated protein deubiquitination (GO:0035520)3.96251457
57DNA packaging (GO:0006323)3.87870450
58spermatid nucleus differentiation (GO:0007289)3.85522472
59regulation of protein deacetylation (GO:0090311)3.80749373
60positive regulation of cellular amide metabolic process (GO:0034250)3.76769892
61gene silencing by RNA (GO:0031047)3.74145376
62potassium ion export (GO:0071435)3.71260535
63multicellular organismal development (GO:0007275)3.69291353
64ether metabolic process (GO:0018904)3.69221826
65oogenesis (GO:0048477)3.62432533
66N-acetylneuraminate metabolic process (GO:0006054)3.58300896
67synapsis (GO:0007129)3.58082806
68intraciliary transport (GO:0042073)3.56012724
69misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.53382141
70protein polyglutamylation (GO:0018095)3.49171546
71meiotic cell cycle process (GO:1903046)3.43752653
72reactive oxygen species biosynthetic process (GO:1903409)3.43603168
73female gamete generation (GO:0007292)3.42192193
74lactate metabolic process (GO:0006089)3.40663135
75detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.35529188
76amino-acid betaine transport (GO:0015838)3.32028812
77carnitine transport (GO:0015879)3.32028812
78regulation of MHC class II biosynthetic process (GO:0045346)3.28708940
79carnitine transmembrane transport (GO:1902603)3.28032982
80ADP metabolic process (GO:0046031)3.25690148
81regulation of spindle checkpoint (GO:0090231)3.24906848
82axoneme assembly (GO:0035082)3.24814501
83meiotic chromosome segregation (GO:0045132)3.23147445
84negative regulation of organelle assembly (GO:1902116)3.19738506
85regulation of hydrogen peroxide-induced cell death (GO:1903205)3.16772646
86signal complex assembly (GO:0007172)3.15232073
87histone exchange (GO:0043486)3.15093311
88sequestering of actin monomers (GO:0042989)3.13579241
89mitotic sister chromatid cohesion (GO:0007064)3.13201187
90reproductive system development (GO:0061458)3.12471665
91left/right axis specification (GO:0070986)3.11562775
92protein refolding (GO:0042026)3.09785082
93polyol catabolic process (GO:0046174)3.09124042
94detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.08460562
95cellular extravasation (GO:0045123)3.08245218
96indole-containing compound catabolic process (GO:0042436)3.08104351
97indolalkylamine catabolic process (GO:0046218)3.08104351
98tryptophan catabolic process (GO:0006569)3.08104351
99regulation of meiosis I (GO:0060631)3.06569142
100microtubule-based movement (GO:0007018)3.06199981
101alditol metabolic process (GO:0019400)3.06155458
102protein K11-linked deubiquitination (GO:0035871)3.00271857
103somite rostral/caudal axis specification (GO:0032525)2.98475144
104nucleoside diphosphate phosphorylation (GO:0006165)2.97599172
105centriole replication (GO:0007099)2.96510780
106nuclear pore complex assembly (GO:0051292)2.95836808
107cilium organization (GO:0044782)2.93709959
108apoptotic process involved in development (GO:1902742)2.90518419
109regulation of centriole replication (GO:0046599)2.90235078
110forebrain neuron development (GO:0021884)2.89966552
111glycolytic process (GO:0006096)2.86794908
112response to folic acid (GO:0051593)2.86717542
113cilium morphogenesis (GO:0060271)2.86454410
114respiratory burst (GO:0045730)2.86146936
115GTP biosynthetic process (GO:0006183)2.86046283
116microtubule polymerization or depolymerization (GO:0031109)2.81862689
117cellular component assembly involved in morphogenesis (GO:0010927)2.81102040
118cellular response to nitric oxide (GO:0071732)2.79385815
119nucleus organization (GO:0006997)2.78749188
120cilium assembly (GO:0042384)2.76734894
121gene silencing (GO:0016458)2.76029849
122carnitine shuttle (GO:0006853)2.75744794
123positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.75170193
124negative regulation of signal transduction by p53 class mediator (GO:1901797)2.74834193
125regulation of protein polyubiquitination (GO:1902914)2.73945700
126hydrogen peroxide biosynthetic process (GO:0050665)2.71845186
127regulation of oxidative stress-induced neuron death (GO:1903203)2.71800030
128negative regulation of macroautophagy (GO:0016242)2.70512150
129amino sugar catabolic process (GO:0046348)2.68893086
130DNA biosynthetic process (GO:0071897)2.66534637
131single strand break repair (GO:0000012)2.66515788
132interferon-gamma secretion (GO:0072643)2.65747497
133glycerol metabolic process (GO:0006071)2.65320764
134negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.60395090
135TOR signaling (GO:0031929)2.59812258
136cellular response to cadmium ion (GO:0071276)2.58576187
137centriole assembly (GO:0098534)2.56613935
138regulation of meiotic cell cycle (GO:0051445)2.56494918
139UTP biosynthetic process (GO:0006228)2.56438693
140circadian sleep/wake cycle process (GO:0022410)2.56083231
141RNA destabilization (GO:0050779)2.53659319
142DNA alkylation (GO:0006305)2.52823631
143DNA methylation (GO:0006306)2.52823631
144regulation of synaptic transmission, dopaminergic (GO:0032225)2.51447792
145chromosome organization (GO:0051276)2.51355718
146tryptophan metabolic process (GO:0006568)2.49523765
147negative regulation of reactive oxygen species metabolic process (GO:2000378)2.48189491
148positive regulation of chemokine biosynthetic process (GO:0045080)2.48087883
149fusion of sperm to egg plasma membrane (GO:0007342)13.6542505
150sperm motility (GO:0030317)12.5145073
151cilium or flagellum-dependent cell motility (GO:0001539)12.4093867
152acrosome assembly (GO:0001675)12.1298583
153sperm-egg recognition (GO:0035036)11.3235207
154multicellular organism reproduction (GO:0032504)10.8525287
155acrosome reaction (GO:0007340)10.7627388
156cell wall macromolecule metabolic process (GO:0044036)10.6441494
157cell wall macromolecule catabolic process (GO:0016998)10.6441494
158binding of sperm to zona pellucida (GO:0007339)10.4940049
159axonemal dynein complex assembly (GO:0070286)10.3998706
160plasma membrane fusion (GO:0045026)10.3942408
161piRNA metabolic process (GO:0034587)10.1463368
162cell-cell recognition (GO:0009988)10.1324947
163DNA synthesis involved in DNA repair (GO:0000731)10.0891255

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.77070681
2EZH2_22144423_ChIP-Seq_EOC_Human5.25830477
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.59169550
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.84185729
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.54558562
6IGF1R_20145208_ChIP-Seq_DFB_Human3.47812981
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.10415599
8ESR1_20079471_ChIP-ChIP_T-47D_Human3.07760454
9GATA1_22025678_ChIP-Seq_K562_Human2.93452518
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.70186917
11ER_23166858_ChIP-Seq_MCF-7_Human2.54101961
12FUS_26573619_Chip-Seq_HEK293_Human2.48890599
13ZNF274_21170338_ChIP-Seq_K562_Hela2.42339364
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.34351542
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31455587
16CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.26746163
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.24659930
18BCAT_22108803_ChIP-Seq_LS180_Human2.24555915
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.16560699
20EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.09122796
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.07028621
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.06867199
23VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.02609104
24AHR_22903824_ChIP-Seq_MCF-7_Human2.01778429
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.4039965
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.99125586
27GATA1_26923725_Chip-Seq_HPCs_Mouse1.99051038
28ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.94505342
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.90675997
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88470377
31ARNT_22903824_ChIP-Seq_MCF-7_Human1.85537791
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.84417827
33ELK4_26923725_Chip-Seq_MESODERM_Mouse1.84069856
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.83524901
35VDR_22108803_ChIP-Seq_LS180_Human1.81568449
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.74250491
37STAT3_23295773_ChIP-Seq_U87_Human1.73810764
38KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.69845280
39TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.65353343
40* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.60695477
41FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60193952
42STAT1_17558387_ChIP-Seq_HELA_Human1.58977468
43RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.56144122
44GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.51589954
45WDR5_24793694_ChIP-Seq_LNCAP_Human1.50650427
46RUNX2_22187159_ChIP-Seq_PCA_Human1.49259157
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49103963
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47810771
49VDR_24787735_ChIP-Seq_THP-1_Human1.46530953
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42048152
51GATA3_21867929_ChIP-Seq_CD8_Mouse1.41099582
52KAP1_22055183_ChIP-Seq_ESCs_Mouse1.40479598
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40219082
54TAL1_26923725_Chip-Seq_HPCs_Mouse1.37420350
55* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.37287689
56MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.36926007
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36302326
58TCF4_23295773_ChIP-Seq_U87_Human1.35745906
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.34422486
60KDM2B_26808549_Chip-Seq_REH_Human1.33396782
61CBP_20019798_ChIP-Seq_JUKART_Human1.32082698
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32082698
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.31768585
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31608646
65AR_21572438_ChIP-Seq_LNCaP_Human1.31250353
66TP53_18474530_ChIP-ChIP_U2OS_Human1.31117708
67ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.29836722
68NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28213226
69FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28001698
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27962785
71SMAD4_21799915_ChIP-Seq_A2780_Human1.27225997
72LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.25695521
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25508329
74AR_25329375_ChIP-Seq_VCAP_Human1.23754691
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21845152
76FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.21457521
77* CJUN_26792858_Chip-Seq_BT549_Human1.21435747
78Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.20818103
79SMAD4_21741376_ChIP-Seq_EPCs_Human1.20788692
80GBX2_23144817_ChIP-Seq_PC3_Human1.20101874
81P300_19829295_ChIP-Seq_ESCs_Human1.19879523
82P53_21459846_ChIP-Seq_SAOS-2_Human1.19730780
83PRDM14_20953172_ChIP-Seq_ESCs_Human1.19038452
84PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18843839
85MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18815461
86REST_21632747_ChIP-Seq_MESCs_Mouse1.18445995
87TP63_23658742_ChIP-Seq_EP156T_Human1.16792627
88* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.16073827
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15959605
90GATA3_21867929_ChIP-Seq_TH1_Mouse1.15547588
91* CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.13984326
92TCF4_18268006_ChIP-ChIP_LS174T_Human1.13631464
93* FLI1_21867929_ChIP-Seq_TH2_Mouse1.13603909
94PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.12536107
95TP53_16413492_ChIP-PET_HCT116_Human1.11003293
96* SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.10937516
97RXR_22108803_ChIP-Seq_LS180_Human1.10780423
98GF1_26923725_Chip-Seq_HPCs_Mouse1.10053424
99TBL1_22424771_ChIP-Seq_293T_Human1.09828295
100EWS_26573619_Chip-Seq_HEK293_Human1.09411611
101CRX_20693478_ChIP-Seq_RETINA_Mouse1.07604930
102RAD21_21589869_ChIP-Seq_MESCs_Mouse1.07031254
103BRD4_25478319_ChIP-Seq_HGPS_Human1.06596082
104NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06011746
105ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04842341
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04334831
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04334831
108RUNX1_26923725_Chip-Seq_HPCs_Mouse1.04178578
109NANOG_18555785_Chip-Seq_ESCs_Mouse1.03918700
110* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03172882
111CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01953653
112CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01008808
113PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00363001
114PKCTHETA_26484144_Chip-Seq_BREAST_Human1.00198819
115SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00127607
116CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99280623
117OCT4_18555785_Chip-Seq_ESCs_Mouse0.98873428
118IKZF1_21737484_ChIP-ChIP_HCT116_Human0.98781356
119RAC3_21632823_ChIP-Seq_H3396_Human0.98440862
120TCF4_22108803_ChIP-Seq_LS180_Human0.97808109
121SMAD_19615063_ChIP-ChIP_OVARY_Human0.96984505
122SPI1_26923725_Chip-Seq_HPCs_Mouse0.96694528
123IRF8_27001747_Chip-Seq_BMDM_Mouse0.96644668
124EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96523887
125AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95924338
126TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95086990
127HOXB7_26014856_ChIP-Seq_BT474_Human0.94965726
128RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94863374
129EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94684394
130RXRA_24833708_ChIP-Seq_LIVER_Mouse0.94560180
131* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94546339
132FOXM1_26456572_ChIP-Seq_MCF-7_Human0.94494034
133BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94466611
134YY1_22570637_ChIP-Seq_MALME-3M_Human0.94300356
135SMC4_20622854_ChIP-Seq_HELA_Human0.94001521
136P53_22387025_ChIP-Seq_ESCs_Mouse0.93678468
137CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93299527
138PIAS1_25552417_ChIP-Seq_VCAP_Human0.92669335
139MYC_27129775_Chip-Seq_CORNEA_Mouse0.92102497
140EZH2_27294783_Chip-Seq_NPCs_Mouse0.91798801
141RARA_24833708_ChIP-Seq_LIVER_Mouse0.91163935
142OCT4_21477851_ChIP-Seq_ESCs_Mouse0.91089329
143* RNF2_27304074_Chip-Seq_NSC_Mouse0.90834668
144PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90815687
145LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.90802756
146* ESET_19884257_ChIP-Seq_ESCs_Mouse0.90565479
147SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90555842
148P300_18555785_Chip-Seq_ESCs_Mouse0.89703979
149OCT1_27270436_Chip-Seq_PROSTATE_Human0.89579817
150* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89563536
151EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.89553950
152KLF4_18555785_Chip-Seq_ESCs_Mouse0.89229669
153* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89167858
154TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.89159811
155TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88853880
156* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88850705
157CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.88418583
158FLI1_21867929_ChIP-Seq_CD8_Mouse0.87103109
159PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.86906599
160RBPJ_22232070_ChIP-Seq_NCS_Mouse0.86083957
161ESRRB_18555785_Chip-Seq_ESCs_Mouse0.85689754
162CDX2_22108803_ChIP-Seq_LS180_Human0.85530250
163TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85494331
164* ERG_20517297_ChIP-Seq_VCAP_Human0.85407506
165SOX2_21211035_ChIP-Seq_LN229_Human0.85373395
166NCOR_22424771_ChIP-Seq_293T_Human0.85009273
167* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84493324
168CMYC_18555785_Chip-Seq_ESCs_Mouse0.84459527
169EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.84076372
170GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.83755756
171FOXA1_21572438_ChIP-Seq_LNCaP_Human0.83199955
172* NANOG_19829295_ChIP-Seq_ESCs_Human0.83109431
173* SOX2_19829295_ChIP-Seq_ESCs_Human0.83109431
174SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83033732
175TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.83020826
176GATA1_19941827_ChIP-Seq_MEL86_Mouse0.82352817
177GF1B_26923725_Chip-Seq_HPCs_Mouse0.80935758

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.01945877
2MP0001929_abnormal_gametogenesis5.63033755
3MP0008877_abnormal_DNA_methylation5.52076846
4MP0008004_abnormal_stomach_pH5.01420504
5MP0005367_renal/urinary_system_phenotyp4.08163890
6MP0000516_abnormal_urinary_system4.08163890
7MP0002210_abnormal_sex_determination3.81512257
8MP0005083_abnormal_biliary_tract3.78316682
9MP0002161_abnormal_fertility/fecundity3.25624700
10MP0001145_abnormal_male_reproductive3.20933872
11MP0000653_abnormal_sex_gland2.77935038
12MP0003315_abnormal_perineum_morphology2.67778610
13MP0003183_abnormal_peptide_metabolism2.61606463
14MP0002653_abnormal_ependyma_morphology2.60909380
15MP0005058_abnormal_lysosome_morphology2.58776482
16MP0010368_abnormal_lymphatic_system2.58405184
17MP0005670_abnormal_white_adipose2.03604264
18MP0005410_abnormal_fertilization15.5802911
19MP0002160_abnormal_reproductive_system1.97726607
20MP0000003_abnormal_adipose_tissue1.86567234
21MP0000678_abnormal_parathyroid_gland1.85507948
22MP0008057_abnormal_DNA_replication1.85209441
23MP0003890_abnormal_embryonic-extraembry1.83152210
24MP0009840_abnormal_foam_cell1.75153314
25MP0001501_abnormal_sleep_pattern1.74619920
26MP0003195_calcinosis1.70637858
27MP0005623_abnormal_meninges_morphology1.64569094
28MP0004043_abnormal_pH_regulation1.63622717
29MP0003646_muscle_fatigue1.53525936
30MP0000343_altered_response_to1.53226586
31MP0005360_urolithiasis1.36358760
32MP0000383_abnormal_hair_follicle1.35983900
33MP0010386_abnormal_urinary_bladder1.34092522
34MP0005167_abnormal_blood-brain_barrier1.28073920
35MP0005174_abnormal_tail_pigmentation1.27221651
36MP0000013_abnormal_adipose_tissue1.27102145
37MP0002282_abnormal_trachea_morphology1.25034492
38MP0002132_abnormal_respiratory_system1.22937549
39MP0008058_abnormal_DNA_repair1.20765894
40MP0004233_abnormal_muscle_weight1.20627422
41MP0005647_abnormal_sex_gland1.17620108
42MP0003221_abnormal_cardiomyocyte_apopto1.14170387
43MP0005375_adipose_tissue_phenotype1.11167898
44MP0010094_abnormal_chromosome_stability1.08450409
45MP0001984_abnormal_olfaction1.07197280
46MP0008995_early_reproductive_senescence1.03624355
47MP0010678_abnormal_skin_adnexa1.01403825
48MP0005389_reproductive_system_phenotype1.00205901
49MP0002837_dystrophic_cardiac_calcinosis1.00020122
50MP0000465_gastrointestinal_hemorrhage0.98717185
51MP0003011_delayed_dark_adaptation0.97491919
52MP0001765_abnormal_ion_homeostasis0.95945387
53MP0001485_abnormal_pinna_reflex0.94807145
54MP0009046_muscle_twitch0.94087363
55MP0009785_altered_susceptibility_to0.92016171
56MP0000537_abnormal_urethra_morphology0.89890886
57MP0000015_abnormal_ear_pigmentation0.88838235
58MP0003786_premature_aging0.88626971
59MP0008007_abnormal_cellular_replicative0.85938407
60MP0002168_other_aberrant_phenotype0.85135451
61MP0005085_abnormal_gallbladder_physiolo0.83263347
62MP0005334_abnormal_fat_pad0.79786039
63MP0000749_muscle_degeneration0.79169804
64MP0002419_abnormal_innate_immunity0.75249834
65MP0000569_abnormal_digit_pigmentation0.75083229
66MP0003632_abnormal_nervous_system0.73564537
67MP0002234_abnormal_pharynx_morphology0.71781635
68MP0005448_abnormal_energy_balance0.69641993
69MP0001664_abnormal_digestion0.69592619
70MP0003828_pulmonary_edema0.67782247
71MP0005266_abnormal_metabolism0.67595954
72MP0002998_abnormal_bone_remodeling0.66773196
73MP0003091_abnormal_cell_migration0.66337181
74MP0005365_abnormal_bile_salt0.66333211
75MP0005397_hematopoietic_system_phenotyp0.63473499
76MP0001545_abnormal_hematopoietic_system0.63473499
77MP0004134_abnormal_chest_morphology0.61836224
78MP0003252_abnormal_bile_duct0.61118699
79MP0003115_abnormal_respiratory_system0.58713160
80MP0005377_hearing/vestibular/ear_phenot0.58589200
81MP0003878_abnormal_ear_physiology0.58589200
82MP0004215_abnormal_myocardial_fiber0.57215395
83MP0009278_abnormal_bone_marrow0.56734735
84MP0003941_abnormal_skin_development0.55540608
85MP0002452_abnormal_antigen_presenting0.55503301
86MP0000358_abnormal_cell_content/0.55481429
87MP0005409_darkened_coat_color0.55412369
88MP0004808_abnormal_hematopoietic_stem0.55212949
89MP0005387_immune_system_phenotype0.54823149
90MP0001790_abnormal_immune_system0.54823149
91MP0003111_abnormal_nucleus_morphology0.53062808
92MP0003699_abnormal_female_reproductive0.51236611
93MP0010307_abnormal_tumor_latency0.50396387
94MP0000681_abnormal_thyroid_gland0.50333186
95MP0003136_yellow_coat_color0.50262615
96MP0005023_abnormal_wound_healing0.49935074
97MP0005310_abnormal_salivary_gland0.49826638
98MP0003950_abnormal_plasma_membrane0.49594287
99MP0000538_abnormal_urinary_bladder0.48532800
100MP0001529_abnormal_vocalization0.47933780
101MP0003329_amyloid_beta_deposits0.47421202
102MP0000733_abnormal_muscle_development0.47223098
103MP0003690_abnormal_glial_cell0.47007407
104MP0005636_abnormal_mineral_homeostasis0.47003937
105MP0002928_abnormal_bile_duct0.46644992
106MP0002127_abnormal_cardiovascular_syste0.46396374
107MP0004036_abnormal_muscle_relaxation0.45400403
108MP0001730_embryonic_growth_arrest0.44579235
109MP0000685_abnormal_immune_system0.44461479
110MP0005666_abnormal_adipose_tissue0.44045017
111MP0002723_abnormal_immune_serum0.43682621
112MP0003303_peritoneal_inflammation0.42939660
113MP0002420_abnormal_adaptive_immunity0.42087334
114MP0001119_abnormal_female_reproductive0.40673358
115MP0001324_abnormal_eye_pigmentation0.40651671
116MP0005253_abnormal_eye_physiology0.39048291
117MP0001293_anophthalmia0.37947125
118MP0002269_muscular_atrophy0.37403160
119MP0006036_abnormal_mitochondrial_physio0.37065047
120MP0005551_abnormal_eye_electrophysiolog0.35220409
121MP0001727_abnormal_embryo_implantation0.35066265
122MP0001764_abnormal_homeostasis0.33083376
123MP0003077_abnormal_cell_cycle0.32173283
124MP0005391_vision/eye_phenotype0.31921725
125MP0004019_abnormal_vitamin_homeostasis0.29450888
126MP0000313_abnormal_cell_death0.27637477
127MP0009115_abnormal_fat_cell0.26709781
128MP0002971_abnormal_brown_adipose0.25786555
129MP0003861_abnormal_nervous_system0.25624806
130MP0000427_abnormal_hair_cycle0.24891249
131MP0001661_extended_life_span0.24537205
132MP0008961_abnormal_basal_metabolism0.24415137
133MP0004133_heterotaxia0.24303268
134MP0004811_abnormal_neuron_physiology0.24134967
135MP0002084_abnormal_developmental_patter0.23142537
136MP0003879_abnormal_hair_cell0.22941075
137MP0000604_amyloidosis0.22589343
138MP0003633_abnormal_nervous_system0.22475191
139MP0002152_abnormal_brain_morphology0.22258335
140MP0000751_myopathy0.22156360
141MP0002139_abnormal_hepatobiliary_system0.22154415
142MP0003045_fibrosis0.22046234
143MP0000534_abnormal_ureter_morphology0.21914837
144MP0003942_abnormal_urinary_system0.19632089
145MP0002092_abnormal_eye_morphology0.18675927
146MP0003631_nervous_system_phenotype0.18584769
147MP0005380_embryogenesis_phenotype0.18309679
148MP0001672_abnormal_embryogenesis/_devel0.18309679
149MP0002169_no_abnormal_phenotype0.17509052
150MP0002873_normal_phenotype0.17270131
151MP0001697_abnormal_embryo_size0.17110599
152MP0001851_eye_inflammation0.16969477
153MP0006035_abnormal_mitochondrial_morpho0.16954880
154MP0006072_abnormal_retinal_apoptosis0.16416615
155MP0002102_abnormal_ear_morphology0.15834655
156MP0003948_abnormal_gas_homeostasis0.14876882
157MP0003936_abnormal_reproductive_system0.14346479
158MP0002080_prenatal_lethality0.13712456
159MP0003984_embryonic_growth_retardation0.13025398
160MP0000001_mammalian_phenotype0.12501373
161MP0004197_abnormal_fetal_growth/weight/0.12417296
162MP0002736_abnormal_nociception_after0.12298633
163MP0002229_neurodegeneration0.12281382
164MP0002108_abnormal_muscle_morphology0.12138230
165MP0002970_abnormal_white_adipose0.11563761

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.49093663
2Abnormal respiratory epithelium morphology (HP:0012253)8.93877290
3Abnormal respiratory motile cilium morphology (HP:0005938)8.93877290
4Rhinitis (HP:0012384)7.93772559
5Chronic bronchitis (HP:0004469)7.58455641
6Abnormal ciliary motility (HP:0012262)7.52644774
7Infertility (HP:0000789)6.53676766
8Nasal polyposis (HP:0100582)6.38950676
9Failure to thrive in infancy (HP:0001531)5.58664218
10Abnormality of the nasal mucosa (HP:0000433)5.24555406
11Febrile seizures (HP:0002373)4.55207467
12Bronchiectasis (HP:0002110)4.52454869
13Bronchitis (HP:0012387)4.48813826
14Nephronophthisis (HP:0000090)4.42922006
15Spontaneous abortion (HP:0005268)4.22623831
16Hypoplasia of the uterus (HP:0000013)3.99003736
17Urinary urgency (HP:0000012)3.93250375
18Resting tremor (HP:0002322)3.79413111
19Male infertility (HP:0003251)3.70214440
20Abnormality of the lower motor neuron (HP:0002366)3.50489427
21Recurrent sinusitis (HP:0011108)3.39463988
22Abnormality of the renal medulla (HP:0100957)3.34410135
23Abnormality of DNA repair (HP:0003254)3.34229842
24Fair hair (HP:0002286)3.28243125
25Recurrent otitis media (HP:0000403)3.26855638
26Facial hemangioma (HP:0000329)3.24483490
27Degeneration of the lateral corticospinal tracts (HP:0002314)3.19620335
28Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.19620335
29Abnormal spermatogenesis (HP:0008669)3.18528944
30Eczematoid dermatitis (HP:0000976)3.17064982
31Gonadotropin excess (HP:0000837)3.06969700
32Abnormality of secondary sexual hair (HP:0009888)3.00569856
33Abnormality of the axillary hair (HP:0100134)3.00569856
34Progressive external ophthalmoplegia (HP:0000590)3.00106201
35Ventricular fibrillation (HP:0001663)2.99558896
36Hyperkalemia (HP:0002153)2.96828026
37Loss of speech (HP:0002371)2.90866796
38Recurrent gram-negative bacterial infections (HP:0005420)2.86482009
39Recurrent bacterial skin infections (HP:0005406)2.84236880
40Tubulointerstitial nephritis (HP:0001970)2.82235338
41Sex reversal (HP:0012245)2.81719532
42Abnormal sex determination (HP:0012244)2.81719532
43Protruding tongue (HP:0010808)2.79052091
44Urinary bladder sphincter dysfunction (HP:0002839)2.76460821
45Amyotrophic lateral sclerosis (HP:0007354)2.75028377
46Abnormality of the columella (HP:0009929)2.68275360
47Molar tooth sign on MRI (HP:0002419)2.68091228
48Abnormality of midbrain morphology (HP:0002418)2.68091228
49Severe global developmental delay (HP:0011344)2.65594770
50Tubular atrophy (HP:0000092)2.64932633
51Hypokalemic alkalosis (HP:0001949)2.63556063
52Generalized hypopigmentation of hair (HP:0011358)2.63096259
53Reduced antithrombin III activity (HP:0001976)2.61515351
54Clumsiness (HP:0002312)2.59634992
55Medial flaring of the eyebrow (HP:0010747)2.59533567
56Fibular hypoplasia (HP:0003038)2.59207385
57Mediastinal lymphadenopathy (HP:0100721)2.56293111
58Papillary thyroid carcinoma (HP:0002895)2.52345391
59Tubulointerstitial abnormality (HP:0001969)2.49850468
60Short nail (HP:0001799)2.46926285
61Abnormality of macrophages (HP:0004311)2.46914131
62Aplasia/hypoplasia of the uterus (HP:0008684)2.43761918
63Recurrent bronchitis (HP:0002837)2.42385948
64Abnormality of the nasal septum (HP:0000419)2.37477135
65High anterior hairline (HP:0009890)2.37458652
66Azoospermia (HP:0000027)2.35943080
67Abnormal auditory evoked potentials (HP:0006958)2.29641818
68Retinal atrophy (HP:0001105)2.29576860
69Epidermoid cyst (HP:0200040)2.28709135
70Impulsivity (HP:0100710)2.27239058
71Postural instability (HP:0002172)2.25371563
72Inappropriate behavior (HP:0000719)2.20637277
73Absent speech (HP:0001344)2.20256591
74Metabolic alkalosis (HP:0200114)2.20234260
75Impaired proprioception (HP:0010831)2.15602205
76Flat occiput (HP:0005469)2.15530273
77Abnormality of the corticospinal tract (HP:0002492)2.12131610
78Genetic anticipation (HP:0003743)2.11995351
79Hypoplasia of the capital femoral epiphysis (HP:0003090)2.10915972
80Colitis (HP:0002583)2.10647447
81Shoulder girdle muscle weakness (HP:0003547)2.10537126
82Long foot (HP:0001833)2.10055101
83Dysmetric saccades (HP:0000641)2.09805305
84Tubulointerstitial fibrosis (HP:0005576)2.07322953
85Rib fusion (HP:0000902)2.05879500
86Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.05764555
87Abnormal protein N-linked glycosylation (HP:0012347)2.05764555
88Abnormal protein glycosylation (HP:0012346)2.05764555
89Abnormal glycosylation (HP:0012345)2.05764555
90Postaxial foot polydactyly (HP:0001830)2.03261181
91Recurrent abscess formation (HP:0002722)2.01998141
92Aplasia/Hypoplasia of the uvula (HP:0010293)2.01486559
93Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.4622362
94Absent/shortened dynein arms (HP:0200106)12.9154540
95Dynein arm defect of respiratory motile cilia (HP:0012255)12.9154540
96Upper motor neuron abnormality (HP:0002127)1.99772553
97Abnormality of chloride homeostasis (HP:0011422)1.97739217
98Stage 5 chronic kidney disease (HP:0003774)1.97689460
99Duodenal stenosis (HP:0100867)1.95396597
100Small intestinal stenosis (HP:0012848)1.95396597
101Abnormality of glycolipid metabolism (HP:0010969)1.90901407
102Abnormality of liposaccharide metabolism (HP:0010968)1.90901407
103Abnormality of glycosphingolipid metabolism (HP:0004343)1.90901407
104Rhabdomyolysis (HP:0003201)1.89824678
105Abnormality of lateral ventricle (HP:0030047)1.88092295
106Exercise-induced myalgia (HP:0003738)1.88077145
107Thoracolumbar scoliosis (HP:0002944)1.86960217
108Decreased subcutaneous fat (HP:0001002)1.86419247
109Congenital sensorineural hearing impairment (HP:0008527)1.86004700
110Polydipsia (HP:0001959)1.85721230
111Abnormal drinking behavior (HP:0030082)1.85721230
112Disinhibition (HP:0000734)1.85448167
113Polyneuropathy (HP:0001271)1.85096307
114Congenital hepatic fibrosis (HP:0002612)1.84651231
115Abnormality of the anterior horn cell (HP:0006802)1.84094441
116Degeneration of anterior horn cells (HP:0002398)1.84094441
117Chromosomal breakage induced by crosslinking agents (HP:0003221)1.83625667
118Abnormality of the renal cortex (HP:0011035)1.81906179
119Aplasia cutis congenita (HP:0001057)1.81891095
120External ophthalmoplegia (HP:0000544)1.81635156
121Neurofibrillary tangles (HP:0002185)1.81632571
122Short ribs (HP:0000773)1.81409368
123Self-mutilation (HP:0000742)1.80700860
124Oculomotor apraxia (HP:0000657)1.78686815
125Clubbing of toes (HP:0100760)1.77955659
126Nephroblastoma (Wilms tumor) (HP:0002667)1.77632565
127Absent frontal sinuses (HP:0002688)1.76005433
128Abnormality of the lumbar spine (HP:0100712)1.75588488
129Myoglobinuria (HP:0002913)1.73811877
130Abnormality of dentin (HP:0010299)1.73572589
131Abnormality of potassium homeostasis (HP:0011042)1.72136329
132Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.71362995
133Absent epiphyses (HP:0010577)1.71362995
134Thoracic kyphosis (HP:0002942)1.71137827
135Renal dysplasia (HP:0000110)1.69346693
136Abnormality of permanent molar morphology (HP:0011071)1.67457968
137Abnormality of the dental root (HP:0006486)1.67457968
138Taurodontia (HP:0000679)1.67457968
139Abnormal gallbladder physiology (HP:0012438)1.66446810
140Cholecystitis (HP:0001082)1.66446810
141Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.63659908
14211 pairs of ribs (HP:0000878)1.63329224
143Facial cleft (HP:0002006)1.61551716
144Aplasia/Hypoplasia of the fibula (HP:0006492)1.60341699
145J-shaped sella turcica (HP:0002680)1.59313261
146Abnormality of renal excretion (HP:0011036)1.58772355
147Spastic tetraparesis (HP:0001285)1.58432343
148Postaxial hand polydactyly (HP:0001162)1.58128782
149Chronic sinusitis (HP:0011109)1.57119280
150Microglossia (HP:0000171)1.55605730
151Abnormality of molar morphology (HP:0011070)1.55248450
152Abnormality of molar (HP:0011077)1.55248450
153Dyschromatopsia (HP:0007641)1.54036522
154Heterotopia (HP:0002282)1.53969141
155Supernumerary spleens (HP:0009799)1.53510960
156Abnormality of the dental pulp (HP:0006479)1.52470933
157Bell-shaped thorax (HP:0001591)1.44606682
158Short thorax (HP:0010306)1.41647384
159Broad distal phalanx of finger (HP:0009836)1.39719229
160Congenital primary aphakia (HP:0007707)1.38309684
161Deformed sella turcica (HP:0002681)1.37879636
162Gait imbalance (HP:0002141)1.37632119
163Cystic liver disease (HP:0006706)1.37136954
164Median cleft lip (HP:0000161)1.36709385
165Aplasia/Hypoplasia of the lens (HP:0008063)1.33173386
166Breast carcinoma (HP:0003002)1.32167637
167Abnormality of ocular smooth pursuit (HP:0000617)1.31831365
168Short femoral neck (HP:0100864)1.29580908
169Selective tooth agenesis (HP:0001592)1.29146708
170Aplasia/Hypoplasia of the tongue (HP:0010295)1.29000393
171Abnormal biliary tract physiology (HP:0012439)1.28991157
172Bile duct proliferation (HP:0001408)1.28991157
173Nephropathy (HP:0000112)1.28871977
174Conjunctival telangiectasia (HP:0000524)1.27409219
175Choroideremia (HP:0001139)1.27353263
176Abnormal urine output (HP:0012590)1.26956711
177Decreased central vision (HP:0007663)1.26613171
178Cerebellar dysplasia (HP:0007033)1.23417884
179Pancreatic fibrosis (HP:0100732)1.21758315
180Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.20828261
181Large eyes (HP:0001090)1.20728903
182Decreased motor nerve conduction velocity (HP:0003431)1.19430420
183Pachygyria (HP:0001302)1.19234726

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK39.03351857
2PDK49.03351857
3PDK25.86706294
4TESK14.93164895
5TAF14.42014800
6FGFR34.27910126
7PRKD33.94257869
8ICK3.54085645
9MAP2K72.84545690
10CAMKK22.84352931
11CAMK1D2.83619187
12CSNK2A22.57152143
13PTK2B2.47423074
14ZAK2.39758145
15WNK42.27514865
16STK392.18616209
17MAP3K62.16976650
18PNCK2.15086431
19TLK12.12426555
20FRK1.95358116
21NEK21.95176612
22MST1R1.76893350
23DYRK1A1.68620991
24TRPM71.55048284
25STK381.47722221
26NEK91.41409759
27MAP3K51.27829989
28LATS11.25945397
29RPS6KA51.20129430
30MYLK1.18582942
31OBSCN1.17416073
32AKT31.16767098
33MAP2K41.14119234
34MELK1.04996885
35DYRK1B1.04404028
36ACVR1B1.03033046
37FGR1.01261601
38MET1.00255426
39PDK10.99999507
40WNK10.98938600
41IRAK30.98284013
42TYRO30.96888783
43MAPK150.96012990
44CDK30.95828486
45OXSR10.94307094
46PASK0.90576764
47ADRBK20.89555218
48STK30.89445089
49CCNB10.87444822
50CDC70.80728837
51DYRK30.76799548
52MATK0.70121335
53MAPK120.69531675
54RET0.69036512
55CHUK0.69028027
56TTK0.68645759
57CAMK10.65454800
58CDK190.63983090
59MAP3K130.63774038
60MAP3K70.61497077
61PINK10.60875633
62IRAK10.60852094
63BLK0.60396448
64WEE10.57030305
65SGK10.55833712
66MAPK130.53644924
67TESK20.53005701
68TIE10.52737010
69LATS20.52589545
70CAMK40.51947606
71CHEK20.50973587
72ATR0.49308341
73CDC42BPA0.49106084
74CHEK10.48452033
75EEF2K0.45413384
76PDPK10.44791722
77CAMK1G0.44237157
78DDR20.40146578
79LMTK20.39786799
80STK38L0.39680509
81TGFBR20.39050715
82GRK70.38918078
83SGK4940.36019285
84SGK2230.36019285
85TAOK30.34810719
86ATM0.33632873
87SGK20.33040363
88NTRK20.32025203
89PKN10.29881603
90MAP2K60.29224390
91CSNK1A1L0.28247305
92PAK10.28091040
93RIPK40.28034198
94MKNK20.27754989
95MTOR0.27649377
96PLK40.27426513
97BMX0.25288016
98MUSK0.25088172
99PRKCG0.25075997
100VRK10.24859118
101CDK120.24796929
102CAMKK10.24296150
103PRKAA20.24204041
104PAK20.23450693
105MAP2K30.23104642
106MAP3K140.22496148
107PLK10.22454492
108IRAK20.22079439
109MAPK110.20703087
110MAP3K30.19969267
111PRKAA10.19607600
112RPS6KB10.19025053
113MAP3K100.18607732
114TGFBR10.17573515
115MAPKAPK50.16921095
116ADRBK10.16580820
117PIM10.15632002
118CSNK1E0.15216157
119MARK20.14494039
120BRSK20.13752317
121MOS0.13324400
122MAP3K90.12599048
123INSR0.10603100
124ERBB40.10001536
125BRAF0.09736695
126NEK60.09567611
127PAK40.09243618
128CSF1R0.07575828
129WNK30.07150051
130STK100.06563441
131PRKCZ0.06388062
132CDK150.06197417
133MARK30.06169162
134PRKCQ0.06135732
135CSNK2A10.06006047
136BMPR1B0.05464419
137CDK10.05094605
138CSNK1D0.04784471
139CDK20.04757810
140PRKACG0.04390195
141MAP3K40.04035723
142CDK180.03989265
143PRKG10.03687593
144RPS6KA10.03417462
145MAPK80.03327669
146GSK3B0.03213818
147CDK11A0.03060130
148PAK60.02742970
149BRSK10.01931210
150PRKDC0.01864481
151STK110.01431590
152BUB10.01136269
153CDK140.00788347
154CAMK2A-0.0467110
155MAPK1-0.0439200
156AURKA-0.0394069
157MAPK10-0.0392162
158CSK-0.0374115
159PRKCA-0.0346016
160CDK6-0.0331036
161PDGFRB-0.0264277
162RPS6KA3-0.0235881
163CDK4-0.0138564
164ZAP70-0.0092438
165EGFR-0.0071877
166PRKCB-0.0070281
167PRKACB-0.0037062
168PRKG2-0.0031166

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.66877139
2Fatty acid biosynthesis_Homo sapiens_hsa000613.78910600
3* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.59854967
4Pathogenic Escherichia coli infection_Homo sapiens_hsa051303.57704051
5* Pyruvate metabolism_Homo sapiens_hsa006203.05392609
6Basal transcription factors_Homo sapiens_hsa030222.92869312
7Selenocompound metabolism_Homo sapiens_hsa004502.88279527
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.73690172
9Pentose phosphate pathway_Homo sapiens_hsa000302.65598682
10Linoleic acid metabolism_Homo sapiens_hsa005912.63911604
11Nitrogen metabolism_Homo sapiens_hsa009102.60708010
12Phagosome_Homo sapiens_hsa041452.54315148
13* Glucagon signaling pathway_Homo sapiens_hsa049222.53154754
14Apoptosis_Homo sapiens_hsa042102.33460684
15Fanconi anemia pathway_Homo sapiens_hsa034602.31448276
16Dorso-ventral axis formation_Homo sapiens_hsa043202.29640444
17Gap junction_Homo sapiens_hsa045402.26952340
18Glycerolipid metabolism_Homo sapiens_hsa005612.11508548
19Oocyte meiosis_Homo sapiens_hsa041142.09157452
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.99789925
21Carbohydrate digestion and absorption_Homo sapiens_hsa049731.84314313
22PPAR signaling pathway_Homo sapiens_hsa033201.81111356
23Amphetamine addiction_Homo sapiens_hsa050311.79957491
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.79629659
25* Propanoate metabolism_Homo sapiens_hsa006401.68582387
26Osteoclast differentiation_Homo sapiens_hsa043801.66809971
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.64705773
28Carbon metabolism_Homo sapiens_hsa012001.57108436
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.56961835
30Huntingtons disease_Homo sapiens_hsa050161.53426370
31TNF signaling pathway_Homo sapiens_hsa046681.50975442
32Fructose and mannose metabolism_Homo sapiens_hsa000511.49986740
33Rheumatoid arthritis_Homo sapiens_hsa053231.46221296
34Lysosome_Homo sapiens_hsa041421.46159831
35Glycerophospholipid metabolism_Homo sapiens_hsa005641.45223744
36Circadian rhythm_Homo sapiens_hsa047101.45113736
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.44315254
38Renin secretion_Homo sapiens_hsa049241.44243811
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.40936622
40Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.40582015
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.35708156
42mRNA surveillance pathway_Homo sapiens_hsa030151.34825093
43TGF-beta signaling pathway_Homo sapiens_hsa043501.30926379
44Fat digestion and absorption_Homo sapiens_hsa049751.30581151
45RNA transport_Homo sapiens_hsa030131.28170467
46Cardiac muscle contraction_Homo sapiens_hsa042601.27507617
47Pertussis_Homo sapiens_hsa051331.25256862
48Antigen processing and presentation_Homo sapiens_hsa046121.23026209
49Olfactory transduction_Homo sapiens_hsa047401.21938442
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.18053749
51Fatty acid metabolism_Homo sapiens_hsa012121.17936805
52Arginine biosynthesis_Homo sapiens_hsa002201.16256777
53Toll-like receptor signaling pathway_Homo sapiens_hsa046201.15780281
54Ether lipid metabolism_Homo sapiens_hsa005651.14842139
55Transcriptional misregulation in cancer_Homo sapiens_hsa052021.12146836
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.11829086
57Nucleotide excision repair_Homo sapiens_hsa034201.11439140
58Fatty acid degradation_Homo sapiens_hsa000711.08386021
59Biosynthesis of amino acids_Homo sapiens_hsa012301.06079706
60Malaria_Homo sapiens_hsa051441.01994013
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.01692161
62Purine metabolism_Homo sapiens_hsa002301.01668207
63Long-term potentiation_Homo sapiens_hsa047201.01183008
64Tuberculosis_Homo sapiens_hsa051520.99263326
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.98985578
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.98407746
67Mineral absorption_Homo sapiens_hsa049780.97712601
68DNA replication_Homo sapiens_hsa030300.97306842
69Staphylococcus aureus infection_Homo sapiens_hsa051500.96989620
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95607617
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.95133568
72Toxoplasmosis_Homo sapiens_hsa051450.94191669
73Butanoate metabolism_Homo sapiens_hsa006500.91608258
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89819064
75NF-kappa B signaling pathway_Homo sapiens_hsa040640.89770265
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.88121967
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88084777
78Amoebiasis_Homo sapiens_hsa051460.87586093
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87117772
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86011193
81FoxO signaling pathway_Homo sapiens_hsa040680.85844122
82Type II diabetes mellitus_Homo sapiens_hsa049300.83724831
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83370734
84Tryptophan metabolism_Homo sapiens_hsa003800.83342918
85Glutathione metabolism_Homo sapiens_hsa004800.82190834
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82009946
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.81975494
88Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.80658282
89ABC transporters_Homo sapiens_hsa020100.78949103
90Estrogen signaling pathway_Homo sapiens_hsa049150.77264323
91Oxytocin signaling pathway_Homo sapiens_hsa049210.77195058
92MAPK signaling pathway_Homo sapiens_hsa040100.76721268
93ECM-receptor interaction_Homo sapiens_hsa045120.76471617
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.76191680
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71534728
96Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71525083
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70435635
98Chemical carcinogenesis_Homo sapiens_hsa052040.68701779
99Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67863557
100VEGF signaling pathway_Homo sapiens_hsa043700.66519448
101Leishmaniasis_Homo sapiens_hsa051400.66387085
102ErbB signaling pathway_Homo sapiens_hsa040120.66132373
103Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65507208
104Collecting duct acid secretion_Homo sapiens_hsa049660.65477220
105Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63050759
106Other glycan degradation_Homo sapiens_hsa005110.62578022
107Systemic lupus erythematosus_Homo sapiens_hsa053220.61163524
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.60692886
109Hematopoietic cell lineage_Homo sapiens_hsa046400.60354640
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59384360
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59104665
112Graft-versus-host disease_Homo sapiens_hsa053320.58730888
113Salmonella infection_Homo sapiens_hsa051320.58270131
114Arachidonic acid metabolism_Homo sapiens_hsa005900.57632222
115Influenza A_Homo sapiens_hsa051640.57286342
116Focal adhesion_Homo sapiens_hsa045100.57176715
117Legionellosis_Homo sapiens_hsa051340.56806357
118Calcium signaling pathway_Homo sapiens_hsa040200.56697166
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55871041
120Hedgehog signaling pathway_Homo sapiens_hsa043400.55324085
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54712074
122Ovarian steroidogenesis_Homo sapiens_hsa049130.52773213
123Asthma_Homo sapiens_hsa053100.52277147
124AMPK signaling pathway_Homo sapiens_hsa041520.52147170
125Small cell lung cancer_Homo sapiens_hsa052220.51112418
126N-Glycan biosynthesis_Homo sapiens_hsa005100.50383284
127Glutamatergic synapse_Homo sapiens_hsa047240.50188998
128mTOR signaling pathway_Homo sapiens_hsa041500.48303160
129African trypanosomiasis_Homo sapiens_hsa051430.47949377
130Renin-angiotensin system_Homo sapiens_hsa046140.47339429
131T cell receptor signaling pathway_Homo sapiens_hsa046600.47055425
132Insulin secretion_Homo sapiens_hsa049110.47019513
133Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45491916
134Thyroid hormone synthesis_Homo sapiens_hsa049180.44675159
135Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42558778
136Axon guidance_Homo sapiens_hsa043600.41679973
137Caffeine metabolism_Homo sapiens_hsa002320.41009418
138Endocytosis_Homo sapiens_hsa041440.40825091
139Bile secretion_Homo sapiens_hsa049760.40253086
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40173341
141Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40165992
142Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40064772
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39501107
144B cell receptor signaling pathway_Homo sapiens_hsa046620.39500478
145Jak-STAT signaling pathway_Homo sapiens_hsa046300.39113206
146* Cysteine and methionine metabolism_Homo sapiens_hsa002700.38075678
147Inositol phosphate metabolism_Homo sapiens_hsa005620.35362673
148Vascular smooth muscle contraction_Homo sapiens_hsa042700.32545684
149* Metabolic pathways_Homo sapiens_hsa011000.32332904
150Homologous recombination_Homo sapiens_hsa034400.31635388
151Alcoholism_Homo sapiens_hsa050340.29541455
152Synaptic vesicle cycle_Homo sapiens_hsa047210.28256632
153Pyrimidine metabolism_Homo sapiens_hsa002400.28215806
154Viral carcinogenesis_Homo sapiens_hsa052030.27345006
155Cell cycle_Homo sapiens_hsa041100.27103392
156Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26714138
157Protein digestion and absorption_Homo sapiens_hsa049740.26491145
158Pancreatic secretion_Homo sapiens_hsa049720.26430421
159RNA degradation_Homo sapiens_hsa030180.25922279
160Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.25734091
161Wnt signaling pathway_Homo sapiens_hsa043100.23670124
162Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.22217542
163Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20785071
164Taste transduction_Homo sapiens_hsa047420.19839684
165Salivary secretion_Homo sapiens_hsa049700.19672327
166cAMP signaling pathway_Homo sapiens_hsa040240.19297198
167Circadian entrainment_Homo sapiens_hsa047130.18902796
168Retinol metabolism_Homo sapiens_hsa008300.15145451
169Gastric acid secretion_Homo sapiens_hsa049710.14892246
170Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.13095839
171HIF-1 signaling pathway_Homo sapiens_hsa040660.11670484

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