ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	indole-containing compound catabolic process (GO:0042436)	4.71022288
2	indolalkylamine catabolic process (GO:0046218)	4.71022288
3	tryptophan catabolic process (GO:0006569)	4.71022288
4	kynurenine metabolic process (GO:0070189)	4.34353462
5	indolalkylamine metabolic process (GO:0006586)	4.33742109
6	protein K11-linked deubiquitination (GO:0035871)	4.12787661
7	neural tube formation (GO:0001841)	4.10496880
8	tryptophan metabolic process (GO:0006568)	4.05832845
9	response to pheromone (GO:0019236)	4.02875057
10	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.95421179
11	L-fucose metabolic process (GO:0042354)	3.94674267
12	L-fucose catabolic process (GO:0042355)	3.94674267
13	fucose catabolic process (GO:0019317)	3.94674267
14	regulation of memory T cell differentiation (GO:0043380)	3.94519743
15	cellular ketone body metabolic process (GO:0046950)	3.61202584
16	negative regulation of mast cell activation (GO:0033004)	3.58081466
17	detection of light stimulus involved in visual perception (GO:0050908)	3.56665752
18	detection of light stimulus involved in sensory perception (GO:0050962)	3.56665752
19	photoreceptor cell maintenance (GO:0045494)	3.45895193
20	signal peptide processing (GO:0006465)	3.43903727
21	behavioral response to nicotine (GO:0035095)	3.37148612
22	DNA double-strand break processing (GO:0000729)	3.31536404
23	ketone body metabolic process (GO:1902224)	3.26328033
24	tachykinin receptor signaling pathway (GO:0007217)	3.23768139
25	cilium or flagellum-dependent cell motility (GO:0001539)	3.22642880
26	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.22397765
27	piRNA metabolic process (GO:0034587)	3.21511456
28	reflex (GO:0060004)	3.20965585
29	indole-containing compound metabolic process (GO:0042430)	3.15500684
30	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.13430699
31	establishment of protein localization to Golgi (GO:0072600)	3.12429461
32	cellular biogenic amine catabolic process (GO:0042402)	3.10215231
33	amine catabolic process (GO:0009310)	3.10215231
34	protein localization to cilium (GO:0061512)	3.10115305
35	regulation of establishment of cell polarity (GO:2000114)	3.07175894
36	axoneme assembly (GO:0035082)	3.06166448
37	adaptation of signaling pathway (GO:0023058)	3.05845644
38	gamma-aminobutyric acid transport (GO:0015812)	3.02128860
39	regulation of action potential (GO:0098900)	3.00653880
40	behavioral response to ethanol (GO:0048149)	2.97135635
41	rRNA catabolic process (GO:0016075)	2.97049851
42	platelet dense granule organization (GO:0060155)	2.95879310
43	regulation of cilium movement (GO:0003352)	2.95360777
44	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.93698709
45	retinal cone cell development (GO:0046549)	2.90049525
46	auditory receptor cell stereocilium organization (GO:0060088)	2.87766225
47	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.86017373
48	regulation of sarcomere organization (GO:0060297)	2.83897910
49	sulfation (GO:0051923)	2.82273803
50	L-methionine salvage (GO:0071267)	2.81011772
51	L-methionine biosynthetic process (GO:0071265)	2.81011772
52	amino acid salvage (GO:0043102)	2.81011772
53	adenosine metabolic process (GO:0046085)	2.79120295
54	negative regulation of multicellular organism growth (GO:0040015)	2.77059882
55	dopamine transport (GO:0015872)	2.76660018
56	epithelial cilium movement (GO:0003351)	2.74085006
57	benzene-containing compound metabolic process (GO:0042537)	2.73463247
58	thyroid hormone metabolic process (GO:0042403)	2.71840279
59	NAD biosynthetic process (GO:0009435)	2.71573403
60	aromatic amino acid family catabolic process (GO:0009074)	2.71291839
61	cilium morphogenesis (GO:0060271)	2.70148296
62	protein prenylation (GO:0018342)	2.67248874
63	prenylation (GO:0097354)	2.67248874
64	neuronal action potential propagation (GO:0019227)	2.66122227
65	DNA deamination (GO:0045006)	2.66114116
66	proline transport (GO:0015824)	2.65527423
67	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.64501111
68	neuronal action potential (GO:0019228)	2.62881222
69	righting reflex (GO:0060013)	2.61467802
70	DNA methylation involved in gamete generation (GO:0043046)	2.61451762
71	recombinational repair (GO:0000725)	2.60795626
72	regulation of establishment or maintenance of cell polarity (GO:0032878)	2.60773995
73	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.60275631
74	double-strand break repair via homologous recombination (GO:0000724)	2.60234402
75	cilium organization (GO:0044782)	2.58094051
76	protein K63-linked deubiquitination (GO:0070536)	2.57888280
77	primary amino compound metabolic process (GO:1901160)	2.56276956
78	preassembly of GPI anchor in ER membrane (GO:0016254)	2.55319300
79	regulation of MHC class I biosynthetic process (GO:0045343)	2.54502625
80	water-soluble vitamin biosynthetic process (GO:0042364)	2.53719109
81	regulation of glucokinase activity (GO:0033131)	2.53605066
82	regulation of hexokinase activity (GO:1903299)	2.53605066
83	glycosphingolipid biosynthetic process (GO:0006688)	2.53580474
84	sphingoid metabolic process (GO:0046519)	2.52888770
85	cilium movement (GO:0003341)	2.52861444
86	inner ear receptor stereocilium organization (GO:0060122)	2.51314316
87	cilium assembly (GO:0042384)	2.50595802
88	serotonin metabolic process (GO:0042428)	2.50357627
89	replication fork processing (GO:0031297)	2.49869607
90	positive regulation of developmental pigmentation (GO:0048087)	2.49711904
91	monoubiquitinated protein deubiquitination (GO:0035520)	2.49224130
92	reciprocal DNA recombination (GO:0035825)	2.48529972
93	reciprocal meiotic recombination (GO:0007131)	2.48529972
94	embryonic epithelial tube formation (GO:0001838)	2.48049469
95	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.47583884
96	regulation of hippo signaling (GO:0035330)	2.47391449
97	methionine biosynthetic process (GO:0009086)	2.45957343
98	startle response (GO:0001964)	2.41572023
99	regulation of meiosis I (GO:0060631)	2.41175731
100	flavonoid metabolic process (GO:0009812)	2.39975032

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.53887343
2	VDR_22108803_ChIP-Seq_LS180_Human	3.22414624
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.17825065
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.02736989
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.87744858
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.87716581
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.67337733
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.62914380
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.51429521
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.43860438
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.43000503
12	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.40671974
13	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.38100874
14	FUS_26573619_Chip-Seq_HEK293_Human	2.17253974
15	P300_19829295_ChIP-Seq_ESCs_Human	2.17244177
16	EWS_26573619_Chip-Seq_HEK293_Human	2.16629324
17	ER_23166858_ChIP-Seq_MCF-7_Human	2.10130648
18	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.05001636
19	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.03084242
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.99058665
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.98421376
22	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.87165253
23	BCAT_22108803_ChIP-Seq_LS180_Human	1.80672566
24	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.77078824
25	SMAD4_21799915_ChIP-Seq_A2780_Human	1.77037276
26	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.73768537
27	STAT3_23295773_ChIP-Seq_U87_Human	1.73302420
28	EZH2_22144423_ChIP-Seq_EOC_Human	1.63973886
29	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.63820101
30	CBP_20019798_ChIP-Seq_JUKART_Human	1.62944596
31	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.62944596
32	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.60849405
33	TCF4_23295773_ChIP-Seq_U87_Human	1.59696015
34	AR_25329375_ChIP-Seq_VCAP_Human	1.57633817
35	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.57131581
36	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.54581786
37	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.53866499
38	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.51253409
39	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.50311538
40	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.49213802
41	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.47418681
42	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.47194517
43	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.42605961
44	TCF4_22108803_ChIP-Seq_LS180_Human	1.42162115
45	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.42061315
46	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.41032621
47	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.37013720
48	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.36023435
49	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.35951438
50	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.35727682
51	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.35130634
52	RUNX2_22187159_ChIP-Seq_PCA_Human	1.34658863
53	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.34520280
54	TP53_22573176_ChIP-Seq_HFKS_Human	1.33428033
55	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.32728081
56	SOX2_19829295_ChIP-Seq_ESCs_Human	1.31547645
57	NANOG_19829295_ChIP-Seq_ESCs_Human	1.31547645
58	IRF1_19129219_ChIP-ChIP_H3396_Human	1.30775475
59	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.30368064
60	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.29209315
61	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.28340063
62	CDX2_22108803_ChIP-Seq_LS180_Human	1.27446074
63	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.27355063
64	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.26625732
65	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.25227671
66	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.25227671
67	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.25203788
68	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.23643379
69	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.22143607
70	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.22143607
71	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.22066336
72	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.21504232
73	AR_21572438_ChIP-Seq_LNCaP_Human	1.19582759
74	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.19444900
75	P53_22387025_ChIP-Seq_ESCs_Mouse	1.18859596
76	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.14477459
77	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.12525789
78	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.11278632
79	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.10213515
80	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.09540288
81	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.09117946
82	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.09116074
83	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08673410
84	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.08179083
85	AR_20517297_ChIP-Seq_VCAP_Human	1.07889662
86	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.07167015
87	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.07123322
88	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.06733222
89	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.03960149
90	P300_18555785_Chip-Seq_ESCs_Mouse	1.03864451
91	NCOR_22424771_ChIP-Seq_293T_Human	1.03838294
92	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.03614120
93	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.02305123
94	KDM2B_26808549_Chip-Seq_REH_Human	1.02076863
95	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.99653629
96	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.99455227
97	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.99091210
98	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.99007067
99	REST_21632747_ChIP-Seq_MESCs_Mouse	0.95800341
100	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.95562891

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.99367289
2	MP0003195_calcinosis	3.90993301
3	MP0002736_abnormal_nociception_after	3.09100762
4	MP0001968_abnormal_touch/_nociception	3.01813054
5	MP0008877_abnormal_DNA_methylation	2.74861743
6	MP0005551_abnormal_eye_electrophysiolog	2.53633573
7	MP0001501_abnormal_sleep_pattern	2.35667357
8	MP0002102_abnormal_ear_morphology	2.27188619
9	MP0009046_muscle_twitch	2.20656018
10	MP0000372_irregular_coat_pigmentation	2.19062663
11	MP0005646_abnormal_pituitary_gland	2.17997980
12	MP0004043_abnormal_pH_regulation	2.10399324
13	MP0002837_dystrophic_cardiac_calcinosis	2.04232331
14	MP0000427_abnormal_hair_cycle	1.93539156
15	MP0009745_abnormal_behavioral_response	1.93286615
16	MP0005253_abnormal_eye_physiology	1.92486469
17	MP0003646_muscle_fatigue	1.90148400
18	MP0006072_abnormal_retinal_apoptosis	1.88432072
19	MP0004147_increased_porphyrin_level	1.87820431
20	MP0003252_abnormal_bile_duct	1.87261766
21	MP0005174_abnormal_tail_pigmentation	1.83433781
22	MP0001986_abnormal_taste_sensitivity	1.81319558
23	MP0010386_abnormal_urinary_bladder	1.74358879
24	MP0002138_abnormal_hepatobiliary_system	1.70726919
25	MP0005645_abnormal_hypothalamus_physiol	1.69322448
26	MP0008872_abnormal_physiological_respon	1.68389945
27	MP0001486_abnormal_startle_reflex	1.61631241
28	MP0008057_abnormal_DNA_replication	1.59863598
29	MP0005075_abnormal_melanosome_morpholog	1.59056058
30	MP0003136_yellow_coat_color	1.52358246
31	MP0002272_abnormal_nervous_system	1.51928052
32	MP0003787_abnormal_imprinting	1.49151474
33	MP0003880_abnormal_central_pattern	1.41306757
34	MP0006276_abnormal_autonomic_nervous	1.40169942
35	MP0002876_abnormal_thyroid_physiology	1.34860451
36	MP0006054_spinal_hemorrhage	1.34337535
37	MP0000383_abnormal_hair_follicle	1.32935625
38	MP0008875_abnormal_xenobiotic_pharmacok	1.31901956
39	MP0005085_abnormal_gallbladder_physiolo	1.29927097
40	MP0003011_delayed_dark_adaptation	1.29509181
41	MP0001984_abnormal_olfaction	1.26295709
42	MP0005410_abnormal_fertilization	1.26203469
43	MP0002735_abnormal_chemical_nociception	1.25790405
44	MP0009697_abnormal_copulation	1.25007715
45	MP0002064_seizures	1.24947139
46	MP0001970_abnormal_pain_threshold	1.23920499
47	MP0004885_abnormal_endolymph	1.19371556
48	MP0004142_abnormal_muscle_tone	1.16909810
49	MP0002733_abnormal_thermal_nociception	1.15562475
50	MP0002938_white_spotting	1.13540772
51	MP0005386_behavior/neurological_phenoty	1.13148623
52	MP0004924_abnormal_behavior	1.13148623
53	MP0002572_abnormal_emotion/affect_behav	1.11929240
54	MP0008058_abnormal_DNA_repair	1.11825812
55	MP0000631_abnormal_neuroendocrine_gland	1.10640054
56	MP0002638_abnormal_pupillary_reflex	1.08706426
57	MP0004215_abnormal_myocardial_fiber	1.07644471
58	MP0005171_absent_coat_pigmentation	1.07395226
59	MP0005310_abnormal_salivary_gland	1.07219474
60	MP0002095_abnormal_skin_pigmentation	1.05599260
61	MP0001764_abnormal_homeostasis	1.03239190
62	MP0003718_maternal_effect	1.02391506
63	MP0003137_abnormal_impulse_conducting	1.00491489
64	MP0001485_abnormal_pinna_reflex	0.99987428
65	MP0000371_diluted_coat_color	0.99736584
66	MP0002067_abnormal_sensory_capabilities	0.99339442
67	MP0005379_endocrine/exocrine_gland_phen	0.97594264
68	MP0000230_abnormal_systemic_arterial	0.96074113
69	MP0002693_abnormal_pancreas_physiology	0.95096837
70	MP0000015_abnormal_ear_pigmentation	0.94484727
71	MP0002928_abnormal_bile_duct	0.93502849
72	MP0000516_abnormal_urinary_system	0.93367350
73	MP0005367_renal/urinary_system_phenotyp	0.93367350
74	MP0002751_abnormal_autonomic_nervous	0.92672379
75	MP0002229_neurodegeneration	0.91420715
76	MP0005389_reproductive_system_phenotype	0.91112869
77	MP0002163_abnormal_gland_morphology	0.89880520
78	MP0005084_abnormal_gallbladder_morpholo	0.88169070
79	MP0005167_abnormal_blood-brain_barrier	0.87441747
80	MP0003635_abnormal_synaptic_transmissio	0.87246532
81	MP0003698_abnormal_male_reproductive	0.86422563
82	MP0002557_abnormal_social/conspecific_i	0.86245063
83	MP0004145_abnormal_muscle_electrophysio	0.84675855
84	MP0005647_abnormal_sex_gland	0.84503854
85	MP0002234_abnormal_pharynx_morphology	0.83994672
86	MP0000647_abnormal_sebaceous_gland	0.82270996
87	MP0002160_abnormal_reproductive_system	0.78838957
88	MP0004133_heterotaxia	0.78616865
89	MP0002653_abnormal_ependyma_morphology	0.77560958
90	MP0005671_abnormal_response_to	0.76865699
91	MP0004742_abnormal_vestibular_system	0.74993757
92	MP0001529_abnormal_vocalization	0.74884921
93	MP0004085_abnormal_heartbeat	0.73808597
94	MP0005332_abnormal_amino_acid	0.73739842
95	MP0005195_abnormal_posterior_eye	0.73459808
96	MP0003950_abnormal_plasma_membrane	0.72928030
97	MP0010329_abnormal_lipoprotein_level	0.72432197
98	MP0001324_abnormal_eye_pigmentation	0.72324596
99	MP0003633_abnormal_nervous_system	0.71981887
100	MP0001929_abnormal_gametogenesis	0.71654618

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.41784927
2	Genetic anticipation (HP:0003743)	3.93347969
3	Pancreatic fibrosis (HP:0100732)	3.88351184
4	True hermaphroditism (HP:0010459)	3.86733326
5	Hyperventilation (HP:0002883)	3.82100286
6	Gaze-evoked nystagmus (HP:0000640)	3.79485104
7	Progressive cerebellar ataxia (HP:0002073)	3.56589474
8	Congenital stationary night blindness (HP:0007642)	3.47564294
9	Attenuation of retinal blood vessels (HP:0007843)	3.42447182
10	Abnormality of midbrain morphology (HP:0002418)	3.36047841
11	Molar tooth sign on MRI (HP:0002419)	3.36047841
12	Abnormality of the renal cortex (HP:0011035)	3.32411366
13	Nephronophthisis (HP:0000090)	3.28039782
14	Abolished electroretinogram (ERG) (HP:0000550)	3.22795515
15	Medial flaring of the eyebrow (HP:0010747)	3.21983675
16	Abnormality of the renal medulla (HP:0100957)	2.96399956
17	Cystic liver disease (HP:0006706)	2.76037183
18	Progressive inability to walk (HP:0002505)	2.75636891
19	Febrile seizures (HP:0002373)	2.68438976
20	Type II lissencephaly (HP:0007260)	2.62356586
21	Fair hair (HP:0002286)	2.60743309
22	Pendular nystagmus (HP:0012043)	2.58004982
23	Congenital sensorineural hearing impairment (HP:0008527)	2.55510352
24	Absent speech (HP:0001344)	2.54966627
25	Inability to walk (HP:0002540)	2.54823794
26	Renal cortical cysts (HP:0000803)	2.52117023
27	Tubular atrophy (HP:0000092)	2.49923358
28	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.49703121
29	Focal motor seizures (HP:0011153)	2.47784888
30	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.46265821
31	Hypoplasia of the fovea (HP:0007750)	2.46265821
32	Congenital primary aphakia (HP:0007707)	2.45292820
33	Focal seizures (HP:0007359)	2.44909969
34	Gait imbalance (HP:0002141)	2.44400933
35	Polydipsia (HP:0001959)	2.42788935
36	Abnormal drinking behavior (HP:0030082)	2.42788935
37	Bony spicule pigmentary retinopathy (HP:0007737)	2.40428359
38	Increased corneal curvature (HP:0100692)	2.39615761
39	Keratoconus (HP:0000563)	2.39615761
40	Chronic hepatic failure (HP:0100626)	2.37096620
41	Absent/shortened dynein arms (HP:0200106)	2.36307752
42	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.36307752
43	Dialeptic seizures (HP:0011146)	2.35429683
44	Large for gestational age (HP:0001520)	2.32410748
45	Abnormal rod and cone electroretinograms (HP:0008323)	2.31328944
46	Nephrogenic diabetes insipidus (HP:0009806)	2.29789507
47	Hemiparesis (HP:0001269)	2.28674487
48	Stomach cancer (HP:0012126)	2.24352970
49	Abnormality of alanine metabolism (HP:0010916)	2.23667833
50	Hyperalaninemia (HP:0003348)	2.23667833
51	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.23667833
52	Protruding tongue (HP:0010808)	2.23274340
53	Clumsiness (HP:0002312)	2.21393455
54	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.20834210
55	Abnormality of macular pigmentation (HP:0008002)	2.20179744
56	Prostate neoplasm (HP:0100787)	2.17672559
57	Constricted visual fields (HP:0001133)	2.16541909
58	Intestinal atresia (HP:0011100)	2.15345035
59	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.13154862
60	Genital tract atresia (HP:0001827)	2.13112269
61	Decreased central vision (HP:0007663)	2.13086417
62	Hypothermia (HP:0002045)	2.12231519
63	Bile duct proliferation (HP:0001408)	2.11143749
64	Abnormal biliary tract physiology (HP:0012439)	2.11143749
65	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.10790489
66	Furrowed tongue (HP:0000221)	2.08421386
67	Abnormality of the fovea (HP:0000493)	2.05867233
68	Congenital hepatic fibrosis (HP:0002612)	2.05859245
69	Decreased circulating renin level (HP:0003351)	2.04598612
70	Generalized hypopigmentation of hair (HP:0011358)	2.03368312
71	Sclerocornea (HP:0000647)	2.03301732
72	Hypoproteinemia (HP:0003075)	1.99606914
73	Broad-based gait (HP:0002136)	1.98801541
74	Vaginal atresia (HP:0000148)	1.98022590
75	Ketoacidosis (HP:0001993)	1.97903631
76	Absence seizures (HP:0002121)	1.96741645
77	Retinitis pigmentosa (HP:0000510)	1.95367599
78	Lissencephaly (HP:0001339)	1.92996345
79	Polyuria (HP:0000103)	1.91365393
80	Thyroiditis (HP:0100646)	1.90536028
81	Widely spaced teeth (HP:0000687)	1.88986303
82	Cerebellar dysplasia (HP:0007033)	1.88456892
83	Male pseudohermaphroditism (HP:0000037)	1.87476627
84	Postaxial foot polydactyly (HP:0001830)	1.85578531
85	Colon cancer (HP:0003003)	1.85490009
86	Methylmalonic acidemia (HP:0002912)	1.81268090
87	Abnormal ciliary motility (HP:0012262)	1.81054075
88	Tubulointerstitial nephritis (HP:0001970)	1.80349811
89	Anencephaly (HP:0002323)	1.79048895
90	Hyperglycinuria (HP:0003108)	1.76482428
91	Congenital, generalized hypertrichosis (HP:0004540)	1.75775834
92	Abnormal respiratory epithelium morphology (HP:0012253)	1.74451443
93	Abnormal respiratory motile cilium morphology (HP:0005938)	1.74451443
94	Chorioretinal atrophy (HP:0000533)	1.74311818
95	Facial diplegia (HP:0001349)	1.71704124
96	Abnormality of the prostate (HP:0008775)	1.71295687
97	Hyperglycinemia (HP:0002154)	1.70703167
98	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.68479675
99	Ketosis (HP:0001946)	1.67240172
100	Tubulointerstitial abnormality (HP:0001969)	1.66748908

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	8.08538600
2	MAP4K2	3.28179146
3	WNK3	2.68694139
4	BMPR1B	2.66112880
5	ADRBK2	2.59151987
6	NUAK1	2.56458992
7	ACVR1B	2.49713877
8	ZAK	2.16724984
9	TAOK3	2.04453787
10	PINK1	2.04016679
11	INSRR	1.99264317
12	GRK1	1.95396566
13	OXSR1	1.93450800
14	MAPK13	1.93050397
15	TRIM28	1.66648431
16	TXK	1.59470219
17	CDK19	1.55922588
18	MKNK2	1.55767899
19	CASK	1.43341583
20	MAP3K4	1.36285106
21	STK38L	1.28354025
22	ERBB3	1.20331441
23	BCR	1.20008907
24	TEC	1.18439072
25	WNK4	1.10361533
26	EIF2AK3	1.08008410
27	ADRBK1	1.05668790
28	DAPK2	1.05042519
29	MKNK1	1.02187773
30	STK39	1.01512990
31	AKT3	1.01036345
32	PRKCE	1.00214641
33	PTK2B	0.96117203
34	FER	0.96106486
35	STK3	0.94437020
36	PLK2	0.93365598
37	CSNK1G2	0.92118374
38	CSNK1G1	0.91741553
39	PAK3	0.89993966
40	CSNK1A1L	0.87869232
41	CSNK1G3	0.84940796
42	TNK2	0.83005017
43	TNIK	0.81080418
44	LATS1	0.80972538
45	MAPKAPK3	0.80722369
46	TGFBR1	0.79796193
47	PRKCG	0.76765769
48	MAP2K7	0.75768558
49	IRAK1	0.74270532
50	ITK	0.69577715
51	TLK1	0.68323532
52	PIK3CA	0.66828011
53	VRK1	0.66377562
54	BRSK2	0.66092130
55	NTRK3	0.64613446
56	PIK3CG	0.64285923
57	MARK1	0.63492135
58	MST4	0.62512718
59	BCKDK	0.61313348
60	NLK	0.61158530
61	TRPM7	0.59052918
62	CAMKK2	0.57173688
63	GRK5	0.56254393
64	FGFR2	0.56114412
65	PRKAA2	0.55900122
66	MAPKAPK5	0.55062961
67	NEK1	0.53208943
68	CAMK2A	0.53075336
69	PLK3	0.53005281
70	GRK7	0.52059597
71	PHKG1	0.48983220
72	PHKG2	0.48983220
73	KIT	0.48066012
74	IKBKB	0.48047661
75	TIE1	0.47996882
76	EPHA4	0.45729163
77	PKN1	0.43724166
78	MAP2K6	0.43154586
79	PRKCQ	0.41986344
80	FLT3	0.40523951
81	PLK4	0.40425395
82	TAF1	0.40244375
83	CSNK1D	0.38782390
84	MAP3K7	0.38028443
85	IGF1R	0.37084436
86	RPS6KA5	0.36586106
87	EPHA3	0.34443537
88	SYK	0.34426068
89	MUSK	0.34182007
90	CSNK1A1	0.34059523
91	CDK3	0.33938229
92	PRKACA	0.33586244
93	SGK2	0.33331766
94	STK11	0.33295371
95	PRKG1	0.33269432
96	EIF2AK2	0.30584974
97	MARK3	0.30538061
98	OBSCN	0.30026076
99	PRKCA	0.29961623
100	LYN	0.28299262

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Butanoate metabolism_Homo sapiens_hsa00650	2.80400212
2	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.58888124
3	Phototransduction_Homo sapiens_hsa04744	2.44815963
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.35861193
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.34820006
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.26093143
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.26080536
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.23343884
9	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.22091199
10	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.11129960
11	Propanoate metabolism_Homo sapiens_hsa00640	2.09841579
12	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.08356374
13	Tryptophan metabolism_Homo sapiens_hsa00380	2.03325299
14	Nicotine addiction_Homo sapiens_hsa05033	2.02936588
15	Ether lipid metabolism_Homo sapiens_hsa00565	2.01647476
16	Homologous recombination_Homo sapiens_hsa03440	1.82544720
17	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.79645680
18	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.78752572
19	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.69351810
20	Caffeine metabolism_Homo sapiens_hsa00232	1.64945446
21	ABC transporters_Homo sapiens_hsa02010	1.64533824
22	Selenocompound metabolism_Homo sapiens_hsa00450	1.58423317
23	Olfactory transduction_Homo sapiens_hsa04740	1.58242950
24	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.57297239
25	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.56142580
26	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.55507605
27	Fanconi anemia pathway_Homo sapiens_hsa03460	1.55443833
28	Taste transduction_Homo sapiens_hsa04742	1.54096211
29	Basal transcription factors_Homo sapiens_hsa03022	1.47489877
30	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.44747922
31	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.38835964
32	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.33313998
33	Morphine addiction_Homo sapiens_hsa05032	1.32575831
34	Retinol metabolism_Homo sapiens_hsa00830	1.32116596
35	Non-homologous end-joining_Homo sapiens_hsa03450	1.26452202
36	Protein export_Homo sapiens_hsa03060	1.24592563
37	Chemical carcinogenesis_Homo sapiens_hsa05204	1.23731605
38	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.20066384
39	Asthma_Homo sapiens_hsa05310	1.16590529
40	Salivary secretion_Homo sapiens_hsa04970	1.13568051
41	Circadian entrainment_Homo sapiens_hsa04713	1.12545787
42	Peroxisome_Homo sapiens_hsa04146	1.12515773
43	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.08516069
44	Regulation of autophagy_Homo sapiens_hsa04140	1.07539440
45	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.06773428
46	beta-Alanine metabolism_Homo sapiens_hsa00410	1.05849489
47	Glutamatergic synapse_Homo sapiens_hsa04724	1.04381069
48	Serotonergic synapse_Homo sapiens_hsa04726	1.02851204
49	GABAergic synapse_Homo sapiens_hsa04727	1.01478170
50	Type I diabetes mellitus_Homo sapiens_hsa04940	0.99580537
51	Glycerolipid metabolism_Homo sapiens_hsa00561	0.99451389
52	RNA polymerase_Homo sapiens_hsa03020	0.93917623
53	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.91739839
54	Graft-versus-host disease_Homo sapiens_hsa05332	0.87945595
55	Circadian rhythm_Homo sapiens_hsa04710	0.84765187
56	Primary immunodeficiency_Homo sapiens_hsa05340	0.84512579
57	Insulin secretion_Homo sapiens_hsa04911	0.82814986
58	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.82002981
59	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.81330910
60	Long-term depression_Homo sapiens_hsa04730	0.81148174
61	Calcium signaling pathway_Homo sapiens_hsa04020	0.78617269
62	RNA degradation_Homo sapiens_hsa03018	0.75844538
63	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.75564818
64	Histidine metabolism_Homo sapiens_hsa00340	0.74626237
65	Fatty acid degradation_Homo sapiens_hsa00071	0.72405245
66	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.71461529
67	Allograft rejection_Homo sapiens_hsa05330	0.68656524
68	Sphingolipid metabolism_Homo sapiens_hsa00600	0.66764965
69	Sulfur metabolism_Homo sapiens_hsa00920	0.66599380
70	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.64735909
71	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.63886522
72	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.62690996
73	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.59569072
74	Fatty acid metabolism_Homo sapiens_hsa01212	0.58750879
75	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.58602004
76	Purine metabolism_Homo sapiens_hsa00230	0.56910158
77	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.54966146
78	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.54641848
79	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.52606746
80	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.51408412
81	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.51231521
82	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.48485068
83	Dopaminergic synapse_Homo sapiens_hsa04728	0.48365245
84	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.47345515
85	Metabolic pathways_Homo sapiens_hsa01100	0.47313160
86	One carbon pool by folate_Homo sapiens_hsa00670	0.46776050
87	Renin secretion_Homo sapiens_hsa04924	0.46435882
88	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.43491888
89	cAMP signaling pathway_Homo sapiens_hsa04024	0.42350083
90	Fat digestion and absorption_Homo sapiens_hsa04975	0.41848335
91	Gastric acid secretion_Homo sapiens_hsa04971	0.41567358
92	Collecting duct acid secretion_Homo sapiens_hsa04966	0.30092199
93	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.29458208
94	Mineral absorption_Homo sapiens_hsa04978	0.28881065
95	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.28521230
96	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.27945985
97	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.27866203
98	Rheumatoid arthritis_Homo sapiens_hsa05323	0.27311903
99	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.26939831
100	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.25474670

LDHAL6CP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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