ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	transepithelial transport (GO:0070633)	7.13304518
2	thalamus development (GO:0021794)	6.83977749
3	polyamine biosynthetic process (GO:0006596)	6.25362385
4	cellular biogenic amine catabolic process (GO:0042402)	6.00562048
5	amine catabolic process (GO:0009310)	6.00562048
6	regulation of interleukin-8 secretion (GO:2000482)	5.85626999
7	negative regulation of appetite (GO:0032099)	5.40891630
8	negative regulation of response to food (GO:0032096)	5.40891630
9	regulation of hexokinase activity (GO:1903299)	5.31524095
10	regulation of glucokinase activity (GO:0033131)	5.31524095
11	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	5.16738174
12	pantothenate metabolic process (GO:0015939)	5.04542535
13	opsonization (GO:0008228)	4.94112978
14	amine biosynthetic process (GO:0009309)	4.71796234
15	cellular biogenic amine biosynthetic process (GO:0042401)	4.67979793
16	negative regulation of thymocyte apoptotic process (GO:0070244)	4.55632832
17	cardiolipin metabolic process (GO:0032048)	4.40867538
18	regulation of platelet aggregation (GO:0090330)	4.19616907
19	bicarbonate transport (GO:0015701)	4.09504034
20	polyamine metabolic process (GO:0006595)	4.03777092
21	negative regulation of homotypic cell-cell adhesion (GO:0034111)	4.02050733
22	peroxisome fission (GO:0016559)	3.98183234
23	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	3.92616504
24	arginine catabolic process (GO:0006527)	3.88796827
25	pyrimidine-containing compound transmembrane transport (GO:0072531)	3.83168449
26	long-chain fatty acid biosynthetic process (GO:0042759)	3.81774969
27	positive regulation of vasodilation (GO:0045909)	3.67475148
28	ADP metabolic process (GO:0046031)	3.66116151
29	positive regulation of T cell differentiation in thymus (GO:0033089)	3.65016593
30	positive regulation of endothelial cell differentiation (GO:0045603)	3.63469308
31	response to lead ion (GO:0010288)	3.62795926
32	retinal cone cell development (GO:0046549)	3.53090696
33	urate metabolic process (GO:0046415)	3.52335974
34	purine ribonucleoside diphosphate metabolic process (GO:0009179)	3.51030472
35	purine nucleoside diphosphate metabolic process (GO:0009135)	3.51030472
36	dopamine transport (GO:0015872)	3.50638489
37	regulation of response to food (GO:0032095)	3.46804462
38	vasodilation (GO:0042311)	3.43837127
39	negative regulation of heart rate (GO:0010459)	3.40967548
40	one-carbon compound transport (GO:0019755)	3.40285949
41	negative regulation of lipid storage (GO:0010888)	3.31955695
42	adenosine metabolic process (GO:0046085)	3.29634474
43	nephron tubule formation (GO:0072079)	3.27617885
44	chronic inflammatory response (GO:0002544)	3.27418693
45	regulation of MHC class II biosynthetic process (GO:0045346)	3.26528747
46	negative regulation of interleukin-8 production (GO:0032717)	3.26234036
47	positive regulation of cAMP-mediated signaling (GO:0043950)	3.25512217
48	regulation of appetite (GO:0032098)	3.24358905
49	response to methylmercury (GO:0051597)	3.22462838
50	nucleoside diphosphate catabolic process (GO:0009134)	3.20360912
51	negative regulation of complement activation (GO:0045916)	3.18525001
52	ribonucleoside diphosphate metabolic process (GO:0009185)	3.15977457
53	regulation of apoptotic process involved in morphogenesis (GO:1902337)	3.15088412
54	transmission of nerve impulse (GO:0019226)	3.13922424
55	modulation by virus of host process (GO:0019054)	3.13338507
56	temperature homeostasis (GO:0001659)	3.11821184
57	membrane hyperpolarization (GO:0060081)	3.11701675
58	sperm capacitation (GO:0048240)	3.10159960
59	acute inflammatory response (GO:0002526)	3.04600026
60	lipoxygenase pathway (GO:0019372)	3.04221974
61	linoleic acid metabolic process (GO:0043651)	3.00996829
62	positive regulation of interleukin-8 biosynthetic process (GO:0045416)	3.00657493
63	type B pancreatic cell proliferation (GO:0044342)	2.99826346
64	regulation of MHC class I biosynthetic process (GO:0045343)	2.98618934
65	regulation of sensory perception (GO:0051931)	2.98166051
66	regulation of sensory perception of pain (GO:0051930)	2.98166051
67	indole-containing compound catabolic process (GO:0042436)	2.98111341
68	indolalkylamine catabolic process (GO:0046218)	2.98111341
69	tryptophan catabolic process (GO:0006569)	2.98111341
70	photoreceptor cell maintenance (GO:0045494)	2.96642961
71	positive regulation of insulin receptor signaling pathway (GO:0046628)	2.96329166
72	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.95038799
73	negative regulation of platelet activation (GO:0010544)	2.91194647
74	regulation of platelet activation (GO:0010543)	2.88555769
75	cellular response to virus (GO:0098586)	2.86968259
76	regulation of macrophage derived foam cell differentiation (GO:0010743)	2.82161166
77	superoxide anion generation (GO:0042554)	2.82036055
78	negative regulation of protein activation cascade (GO:2000258)	2.80013168
79	negative regulation of inflammatory response to antigenic stimulus (GO:0002862)	2.78389709
80	negative regulation of neurotransmitter transport (GO:0051589)	2.77703890
81	leukocyte tethering or rolling (GO:0050901)	2.76438672
82	regulation of homotypic cell-cell adhesion (GO:0034110)	2.69090294
83	response to epinephrine (GO:0071871)	2.67025645
84	prenylation (GO:0097354)	2.66708523
85	protein prenylation (GO:0018342)	2.66708523
86	positive regulation of glomerulus development (GO:0090193)	2.64865237
87	regulation of endothelial cell differentiation (GO:0045601)	2.63306684
88	positive regulation of B cell differentiation (GO:0045579)	2.63193196
89	negative regulation of response to extracellular stimulus (GO:0032105)	2.62775701
90	negative regulation of response to nutrient levels (GO:0032108)	2.62775701
91	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.61426434
92	tryptophan metabolic process (GO:0006568)	2.60252121
93	carnitine metabolic process (GO:0009437)	2.58518331
94	positive regulation of macrophage differentiation (GO:0045651)	2.58298793
95	indolalkylamine metabolic process (GO:0006586)	2.57915539
96	reactive oxygen species biosynthetic process (GO:1903409)	2.56869778
97	establishment of skin barrier (GO:0061436)	2.56518223
98	glycosphingolipid biosynthetic process (GO:0006688)	2.55737900
99	cellular response to nicotine (GO:0071316)	2.54305282
100	renal tubule morphogenesis (GO:0061333)	2.53485624

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.00389000
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.59652052
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.56424469
4	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.71602571
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.64611900
6	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	2.45634279
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.12227062
8	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.10436249
9	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.06708957
10	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.04812233
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.02959989
12	SMAD_19615063_ChIP-ChIP_OVARY_Human	2.00164966
13	VDR_22108803_ChIP-Seq_LS180_Human	1.94590241
14	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.94398401
15	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.94398401
16	P300_19829295_ChIP-Seq_ESCs_Human	1.93084861
17	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.89844868
18	AR_21572438_ChIP-Seq_LNCaP_Human	1.89278501
19	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.86570934
20	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.84865945
21	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.82899453
22	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.81530112
23	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.74476300
24	ZNF274_21170338_ChIP-Seq_K562_Hela	1.71715042
25	TAF15_26573619_Chip-Seq_HEK293_Human	1.70775337
26	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.69212287
27	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.68815782
28	IRF1_19129219_ChIP-ChIP_H3396_Human	1.67427654
29	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.59090856
30	ER_23166858_ChIP-Seq_MCF-7_Human	1.57337203
31	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.56892028
32	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.46424347
33	TP53_16413492_ChIP-PET_HCT116_Human	1.44760989
34	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.43750035
35	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.43367939
36	AR_25329375_ChIP-Seq_VCAP_Human	1.40674945
37	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.40500958
38	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.38714319
39	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.37898980
40	TCF4_22108803_ChIP-Seq_LS180_Human	1.35648737
41	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.35359809
42	EWS_26573619_Chip-Seq_HEK293_Human	1.35299687
43	CJUN_26792858_Chip-Seq_BT549_Human	1.34848657
44	SMAD4_21799915_ChIP-Seq_A2780_Human	1.29985093
45	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.29931759
46	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.29650416
47	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.29565429
48	STAT3_23295773_ChIP-Seq_U87_Human	1.29054786
49	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.28969056
50	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.27980252
51	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.27909010
52	CDX2_22108803_ChIP-Seq_LS180_Human	1.26674641
53	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.26459561
54	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.25790016
55	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.23864605
56	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.23707440
57	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.23280957
58	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.22951929
59	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.20877155
60	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.19333643
61	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.19183593
62	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.17812916
63	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.16432891
64	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.16417841
65	LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.15822825
66	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.14884710
67	CBP_20019798_ChIP-Seq_JUKART_Human	1.14884710
68	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13570782
69	TCF4_23295773_ChIP-Seq_U87_Human	1.12548889
70	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.11653825
71	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.11537656
72	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.09605930
73	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.09323494
74	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.09009770
75	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.09009770
76	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.07961083
77	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.07425071
78	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.07389190
79	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.06963485
80	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.06941220
81	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.06400901
82	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.06394304
83	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.06081866
84	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.06018068
85	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.05592226
86	REST_21632747_ChIP-Seq_MESCs_Mouse	1.05537876
87	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.05374928
88	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.05329687
89	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.03700263
90	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.03700263
91	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.02993803
92	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.02517603
93	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.02509056
94	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.02062117
95	BCAT_22108803_ChIP-Seq_LS180_Human	1.01883116
96	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.00843006
97	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.99604739
98	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.99498792
99	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.98135448
100	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.97701378

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002138_abnormal_hepatobiliary_system	5.93330696
2	MP0008004_abnormal_stomach_pH	5.64794987
3	MP0003300_gastrointestinal_ulcer	5.56855472
4	MP0002163_abnormal_gland_morphology	4.91802858
5	MP0005085_abnormal_gallbladder_physiolo	4.36138851
6	MP0003252_abnormal_bile_duct	4.19266983
7	MP0010386_abnormal_urinary_bladder	3.94239250
8	MP0002132_abnormal_respiratory_system	3.88367847
9	MP0004043_abnormal_pH_regulation	3.06092063
10	MP0002736_abnormal_nociception_after	2.91810727
11	MP0003724_increased_susceptibility_to	2.69451048
12	MP0002277_abnormal_respiratory_mucosa	2.64293610
13	MP0001664_abnormal_digestion	2.60528076
14	MP0005379_endocrine/exocrine_gland_phen	2.59526115
15	MP0005083_abnormal_biliary_tract	2.57117307
16	MP0005365_abnormal_bile_salt	2.42745393
17	MP0008872_abnormal_physiological_respon	2.30137110
18	MP0005084_abnormal_gallbladder_morpholo	2.23176575
19	MP0005464_abnormal_platelet_physiology	2.15992251
20	MP0005670_abnormal_white_adipose	2.12594585
21	MP0005645_abnormal_hypothalamus_physiol	1.96067761
22	MP0000465_gastrointestinal_hemorrhage	1.95441437
23	MP0004084_abnormal_cardiac_muscle	1.92384124
24	MP0008569_lethality_at_weaning	1.70779031
25	MP0001968_abnormal_touch/_nociception	1.65928131
26	MP0005167_abnormal_blood-brain_barrier	1.52492292
27	MP0002928_abnormal_bile_duct	1.52283291
28	MP0002089_abnormal_postnatal_growth/wei	1.50902922
29	MP0002139_abnormal_hepatobiliary_system	1.50774534
30	MP0009764_decreased_sensitivity_to	1.42097814
31	MP0001545_abnormal_hematopoietic_system	1.38493404
32	MP0005397_hematopoietic_system_phenotyp	1.38493404
33	MP0005410_abnormal_fertilization	1.35969289
34	MP0000613_abnormal_salivary_gland	1.23825925
35	MP0003195_calcinosis	1.21462426
36	MP0003646_muscle_fatigue	1.19918210
37	MP0001663_abnormal_digestive_system	1.18308472
38	MP0005220_abnormal_exocrine_pancreas	1.15209095
39	MP0004142_abnormal_muscle_tone	1.14133966
40	MP0002876_abnormal_thyroid_physiology	1.13417603
41	MP0005257_abnormal_intraocular_pressure	1.11982170
42	MP0000538_abnormal_urinary_bladder	0.99601409
43	MP0003303_peritoneal_inflammation	0.98400536
44	MP0003718_maternal_effect	0.93511454
45	MP0000462_abnormal_digestive_system	0.86984546
46	MP0001177_atelectasis	0.84456650
47	MP0010329_abnormal_lipoprotein_level	0.82755452
48	MP0001501_abnormal_sleep_pattern	0.80821918
49	MP0008874_decreased_physiological_sensi	0.80045222
50	MP0003950_abnormal_plasma_membrane	0.78775993
51	MP0002733_abnormal_thermal_nociception	0.78135149
52	MP0001486_abnormal_startle_reflex	0.77720170
53	MP0002118_abnormal_lipid_homeostasis	0.77618012
54	MP0000343_altered_response_to	0.73745831
55	MP0005595_abnormal_vascular_smooth	0.72967051
56	MP0003137_abnormal_impulse_conducting	0.71399904
57	MP0008877_abnormal_DNA_methylation	0.71169111
58	MP0008875_abnormal_xenobiotic_pharmacok	0.67883961
59	MP0002249_abnormal_larynx_morphology	0.66059369
60	MP0005174_abnormal_tail_pigmentation	0.64710634
61	MP0001270_distended_abdomen	0.63485593
62	MP0005381_digestive/alimentary_phenotyp	0.62916762
63	MP0003045_fibrosis	0.62698063
64	MP0005551_abnormal_eye_electrophysiolog	0.61949680
65	MP0004085_abnormal_heartbeat	0.61854485
66	MP0001970_abnormal_pain_threshold	0.60986210
67	MP0004233_abnormal_muscle_weight	0.60235122
68	MP0003186_abnormal_redox_activity	0.59940901
69	MP0009785_altered_susceptibility_to	0.59586691
70	MP0003011_delayed_dark_adaptation	0.58463698
71	MP0002234_abnormal_pharynx_morphology	0.58416269
72	MP0009697_abnormal_copulation	0.58407332
73	MP0002184_abnormal_innervation	0.57748975
74	MP0000249_abnormal_blood_vessel	0.56063061
75	MP0009278_abnormal_bone_marrow	0.55802835
76	MP0000230_abnormal_systemic_arterial	0.54339816
77	MP0005310_abnormal_salivary_gland	0.53910429
78	MP0009745_abnormal_behavioral_response	0.53543170
79	MP0002572_abnormal_emotion/affect_behav	0.53273310
80	MP0005248_abnormal_Harderian_gland	0.53128735
81	MP0002233_abnormal_nose_morphology	0.52246240
82	MP0004036_abnormal_muscle_relaxation	0.51464097
83	MP0003656_abnormal_erythrocyte_physiolo	0.51156356
84	MP0005319_abnormal_enzyme/_coenzyme	0.50689407
85	MP0003787_abnormal_imprinting	0.50476529
86	MP0005025_abnormal_response_to	0.49560651
87	MP0003890_abnormal_embryonic-extraembry	0.48840673
88	MP0009765_abnormal_xenobiotic_induced	0.47459211
89	MP0002067_abnormal_sensory_capabilities	0.46518943
90	MP0000467_abnormal_esophagus_morphology	0.45033394
91	MP0002064_seizures	0.44584858
92	MP0003868_abnormal_feces_composition	0.44348164
93	MP0003959_abnormal_lean_body	0.44062918
94	MP0005360_urolithiasis	0.43955437
95	MP0009643_abnormal_urine_homeostasis	0.43402611
96	MP0005636_abnormal_mineral_homeostasis	0.43197956
97	MP0005253_abnormal_eye_physiology	0.41174801
98	MP0005647_abnormal_sex_gland	0.40886456
99	MP0003633_abnormal_nervous_system	0.40091653
100	MP0001984_abnormal_olfaction	0.39840668

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Ileus (HP:0002595)	7.06465382
2	Rectal prolapse (HP:0002035)	6.57379217
3	Conjugated hyperbilirubinemia (HP:0002908)	5.61560121
4	Petechiae (HP:0000967)	5.35725847
5	Abnormality of the right ventricle (HP:0001707)	4.76271257
6	Male infertility (HP:0003251)	4.68625612
7	Prolonged bleeding time (HP:0003010)	4.39799892
8	Type II lissencephaly (HP:0007260)	3.96039692
9	Azoospermia (HP:0000027)	3.66583943
10	Exocrine pancreatic insufficiency (HP:0001738)	3.65096657
11	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.54476656
12	Hematochezia (HP:0002573)	3.44888107
13	Increased mean platelet volume (HP:0011877)	3.40777139
14	Intrahepatic cholestasis (HP:0001406)	3.39168526
15	Abnormality of chloride homeostasis (HP:0011422)	3.34421214
16	Split foot (HP:0001839)	3.29723793
17	Gaze-evoked nystagmus (HP:0000640)	3.24083716
18	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	3.10475401
19	Anterior segment dysgenesis (HP:0007700)	3.10177629
20	Abnormal platelet volume (HP:0011876)	3.06547496
21	Optic nerve hypoplasia (HP:0000609)	2.96733066
22	Pulmonary fibrosis (HP:0002206)	2.93198878
23	Increased density of long bones (HP:0006392)	2.91784344
24	Hypophosphatemic rickets (HP:0004912)	2.90135977
25	Hyperventilation (HP:0002883)	2.88970833
26	Hypoplasia of the uterus (HP:0000013)	2.86420204
27	Peripheral hypomyelination (HP:0007182)	2.81114533
28	Fair hair (HP:0002286)	2.78282126
29	Enlarged kidneys (HP:0000105)	2.71580217
30	Ankle clonus (HP:0011448)	2.70325819
31	Impaired platelet aggregation (HP:0003540)	2.65538052
32	Abnormal platelet function (HP:0011869)	2.65538052
33	Spontaneous hematomas (HP:0007420)	2.61083025
34	Menorrhagia (HP:0000132)	2.60814100
35	Abnormal biliary tract morphology (HP:0012440)	2.58309894
36	Stomach cancer (HP:0012126)	2.58244944
37	Cerebellar dysplasia (HP:0007033)	2.55428616
38	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.47877432
39	Abnormality of the renal cortex (HP:0011035)	2.46167687
40	Ureteral obstruction (HP:0006000)	2.44855557
41	Myoglobinuria (HP:0002913)	2.44303227
42	Abnormality of purine metabolism (HP:0004352)	2.40859382
43	Abnormal rod and cone electroretinograms (HP:0008323)	2.40595824
44	Ureteral stenosis (HP:0000071)	2.38506523
45	Epistaxis (HP:0000421)	2.35013893
46	Purpura (HP:0000979)	2.34346778
47	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	2.34062732
48	Severe visual impairment (HP:0001141)	2.33328493
49	Abnormality of the prostate (HP:0008775)	2.32799675
50	Short hallux (HP:0010109)	2.32176572
51	Protruding tongue (HP:0010808)	2.31654960
52	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.31572037
53	Gingival bleeding (HP:0000225)	2.28374463
54	Retinal dysplasia (HP:0007973)	2.27769463
55	Inability to walk (HP:0002540)	2.25590276
56	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.24825089
57	Brushfield spots (HP:0001088)	2.21525700
58	Late onset (HP:0003584)	2.21409608
59	Pancreatic cysts (HP:0001737)	2.19308200
60	Abnormal spermatogenesis (HP:0008669)	2.18893793
61	Aplasia/Hypoplasia of the hallux (HP:0008362)	2.18828063
62	Abnormality of male internal genitalia (HP:0000022)	2.17452385
63	Renal cortical cysts (HP:0000803)	2.15460987
64	Increased corneal curvature (HP:0100692)	2.13706652
65	Keratoconus (HP:0000563)	2.13706652
66	Facial hemangioma (HP:0000329)	2.10823278
67	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.08552498
68	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	2.06999045
69	Abnormality of the renal medulla (HP:0100957)	2.06713696
70	Glucose intolerance (HP:0000833)	2.02899650
71	Lissencephaly (HP:0001339)	2.01824114
72	Abnormality of the middle phalanges of the toes (HP:0010183)	2.01311671
73	Renal tubular acidosis (HP:0001947)	2.00817907
74	Pachygyria (HP:0001302)	1.99795608
75	Decreased central vision (HP:0007663)	1.97370039
76	Febrile seizures (HP:0002373)	1.96748706
77	Congenital stationary night blindness (HP:0007642)	1.95771409
78	Shawl scrotum (HP:0000049)	1.94736030
79	Hemiplegia (HP:0002301)	1.93951121
80	Polymicrogyria (HP:0002126)	1.93305525
81	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	1.90510548
82	Short 1st metacarpal (HP:0010034)	1.90510548
83	Generalized hypopigmentation of hair (HP:0011358)	1.84975134
84	Aplasia/hypoplasia of the uterus (HP:0008684)	1.83845143
85	Gastrointestinal dysmotility (HP:0002579)	1.82268219
86	Capillary hemangiomas (HP:0005306)	1.78454865
87	Broad-based gait (HP:0002136)	1.78435947
88	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.75300861
89	Abnormal pancreas size (HP:0012094)	1.74456030
90	Nephronophthisis (HP:0000090)	1.73880112
91	Albinism (HP:0001022)	1.72679108
92	Abnormality of the labia minora (HP:0012880)	1.71524898
93	Agitation (HP:0000713)	1.71434863
94	Medial flaring of the eyebrow (HP:0010747)	1.70860669
95	Tented upper lip vermilion (HP:0010804)	1.69511541
96	Vacuolated lymphocytes (HP:0001922)	1.68525960
97	Abnormality of the 1st metacarpal (HP:0010009)	1.68328489
98	Hyperlipoproteinemia (HP:0010980)	1.67176456
99	Abnormality of the anterior chamber (HP:0000593)	1.66431748
100	Bulbous nose (HP:0000414)	1.64168317

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ARAF	4.65767712
2	PIM2	3.62038489
3	PRKG2	2.79065779
4	MAP3K10	2.54663613
5	WNK3	2.10710114
6	MAP4K2	2.06152455
7	LMTK2	12.1418432
8	STK38L	1.95962314
9	BRAF	1.87393845
10	RAF1	1.80810735
11	EIF2AK1	1.61486243
12	TEC	1.46716320
13	FRK	1.43573671
14	ZAK	1.34033295
15	NUAK1	1.29750445
16	EPHA3	1.27476897
17	DMPK	1.19306816
18	VRK2	1.14426264
19	DYRK2	1.08629774
20	NLK	1.05288243
21	PDK2	1.05287279
22	TNK2	1.05078055
23	TNIK	1.02461924
24	KDR	1.01809779
25	INSRR	0.92766741
26	PRKCE	0.90629721
27	TAOK3	0.89501523
28	GRK5	0.82468091
29	STK24	0.80559398
30	PRKCI	0.79463451
31	PLK2	0.77465009
32	PHKG1	0.76900892
33	PHKG2	0.76900892
34	ADRBK2	0.75974866
35	MAP3K4	0.72889741
36	GRK1	0.71616687
37	HIPK2	0.71464707
38	TRIM28	0.71001604
39	STK39	0.66357389
40	PIK3CA	0.65160049
41	AKT3	0.64806722
42	PRKCQ	0.64609116
43	ROCK1	0.63850627
44	BMX	0.62659478
45	MAP2K7	0.61752304
46	RPS6KA5	0.61297738
47	PTK2B	0.60948584
48	TRPM7	0.55175457
49	MAPKAPK3	0.54293519
50	OXSR1	0.52377415
51	RPS6KA2	0.51248482
52	FLT3	0.50700390
53	RPS6KA6	0.48801679
54	DAPK2	0.48206343
55	BMPR1B	0.46752351
56	PRKAA1	0.45955983
57	MAP2K4	0.45793399
58	MAPK13	0.42524232
59	BCR	0.42344248
60	RPS6KC1	0.41778656
61	RPS6KL1	0.41778656
62	PIM1	0.40073888
63	PKN1	0.37961347
64	TAF1	0.37324550
65	DYRK1A	0.37029142
66	STK38	0.36600607
67	ICK	0.35545670
68	PAK3	0.35033753
69	CAMK2G	0.33861396
70	PRKD1	0.33298568
71	EPHA4	0.32799329
72	DAPK1	0.31626389
73	PNCK	0.31261186
74	MAPK11	0.31144263
75	MARK1	0.30767140
76	PKN2	0.28663747
77	PRKAA2	0.27136830
78	CHEK2	0.26069733
79	PBK	0.25768789
80	PRKG1	0.24916080
81	GRK6	0.24822241
82	CSNK1G3	0.24549794
83	SGK2	0.23944069
84	CAMKK2	0.23697139
85	CSNK1G1	0.23642729
86	PRKACA	0.23410033
87	DDR2	0.23226023
88	VRK1	0.22687858
89	MAP3K12	0.22626734
90	PRKCG	0.21859238
91	PRKACG	0.21478663
92	ADRBK1	0.20810463
93	MAPKAPK5	0.20427579
94	GRK7	0.20363531
95	FGFR1	0.19863545
96	MELK	0.18366063
97	PRKCH	0.18303631
98	MYLK	0.18009215
99	ERBB2	0.17907029
100	MAPK3	0.16725925

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	ABC transporters_Homo sapiens_hsa02010	2.97518525
2	Butanoate metabolism_Homo sapiens_hsa00650	2.88970018
3	Caffeine metabolism_Homo sapiens_hsa00232	2.43092290
4	Bile secretion_Homo sapiens_hsa04976	2.34112349
5	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	2.33469267
6	beta-Alanine metabolism_Homo sapiens_hsa00410	2.24995787
7	Circadian rhythm_Homo sapiens_hsa04710	2.06783871
8	Arginine and proline metabolism_Homo sapiens_hsa00330	2.06433143
9	Arachidonic acid metabolism_Homo sapiens_hsa00590	2.01907615
10	Fatty acid metabolism_Homo sapiens_hsa01212	1.90084545
11	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.87989355
12	Salivary secretion_Homo sapiens_hsa04970	1.87650617
13	Pancreatic secretion_Homo sapiens_hsa04972	1.87561123
14	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.87464737
15	Nitrogen metabolism_Homo sapiens_hsa00910	1.75584479
16	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.74127371
17	Long-term depression_Homo sapiens_hsa04730	1.73191117
18	Fatty acid degradation_Homo sapiens_hsa00071	1.62041269
19	Platelet activation_Homo sapiens_hsa04611	1.60409043
20	Glycerolipid metabolism_Homo sapiens_hsa00561	1.58774077
21	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.47788063
22	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.41826297
23	Linoleic acid metabolism_Homo sapiens_hsa00591	1.40344651
24	Gastric acid secretion_Homo sapiens_hsa04971	1.36579285
25	Serotonergic synapse_Homo sapiens_hsa04726	1.36094534
26	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.35864910
27	Hepatitis C_Homo sapiens_hsa05160	1.34527633
28	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.30481314
29	Nicotine addiction_Homo sapiens_hsa05033	1.29384648
30	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.26878759
31	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.20522682
32	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.20205951
33	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.19613454
34	Chemical carcinogenesis_Homo sapiens_hsa05204	1.19292819
35	Circadian entrainment_Homo sapiens_hsa04713	1.17648655
36	Complement and coagulation cascades_Homo sapiens_hsa04610	1.13158027
37	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.09945018
38	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.02064344
39	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.99166769
40	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.98253230
41	Phototransduction_Homo sapiens_hsa04744	0.97910966
42	Acute myeloid leukemia_Homo sapiens_hsa05221	0.97754586
43	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.97202134
44	Retinol metabolism_Homo sapiens_hsa00830	0.96951606
45	cAMP signaling pathway_Homo sapiens_hsa04024	0.96019625
46	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.95674588
47	Tryptophan metabolism_Homo sapiens_hsa00380	0.94913931
48	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.92021988
49	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.91584121
50	Endometrial cancer_Homo sapiens_hsa05213	0.91390484
51	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.86937680
52	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.86918299
53	Morphine addiction_Homo sapiens_hsa05032	0.86052985
54	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.84781810
55	Glutathione metabolism_Homo sapiens_hsa00480	0.82768857
56	Malaria_Homo sapiens_hsa05144	0.81775732
57	Gap junction_Homo sapiens_hsa04540	0.78463621
58	Ether lipid metabolism_Homo sapiens_hsa00565	0.75308179
59	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.75123185
60	Sulfur metabolism_Homo sapiens_hsa00920	0.74854766
61	Olfactory transduction_Homo sapiens_hsa04740	0.73657792
62	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.73531307
63	Non-small cell lung cancer_Homo sapiens_hsa05223	0.73473662
64	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.73376950
65	Mineral absorption_Homo sapiens_hsa04978	0.71530310
66	PPAR signaling pathway_Homo sapiens_hsa03320	0.71244883
67	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.69788266
68	Chemokine signaling pathway_Homo sapiens_hsa04062	0.64848518
69	ECM-receptor interaction_Homo sapiens_hsa04512	0.63519520
70	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.62607639
71	Peroxisome_Homo sapiens_hsa04146	0.62513678
72	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.62185568
73	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.62034390
74	GABAergic synapse_Homo sapiens_hsa04727	0.62015269
75	Pertussis_Homo sapiens_hsa05133	0.60227039
76	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.58775145
77	Renin secretion_Homo sapiens_hsa04924	0.57629796
78	Vibrio cholerae infection_Homo sapiens_hsa05110	0.57595357
79	Regulation of autophagy_Homo sapiens_hsa04140	0.56828746
80	Choline metabolism in cancer_Homo sapiens_hsa05231	0.56721987
81	Histidine metabolism_Homo sapiens_hsa00340	0.52611454
82	Tyrosine metabolism_Homo sapiens_hsa00350	0.51485791
83	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.49254340
84	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.48892991
85	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.48486222
86	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.47620778
87	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.47396203
88	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.47013711
89	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.46395479
90	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.43742913
91	Protein export_Homo sapiens_hsa03060	0.43653155
92	Sphingolipid metabolism_Homo sapiens_hsa00600	0.43261678
93	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.42473597
94	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.42137230
95	Fatty acid elongation_Homo sapiens_hsa00062	0.41786005
96	Cardiac muscle contraction_Homo sapiens_hsa04260	0.41772346
97	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.41712527
98	Glutamatergic synapse_Homo sapiens_hsa04724	0.41485429
99	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.38334223
100	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.35791106

LDHAL6EP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »