LDHAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.71260242
2proteasome assembly (GO:0043248)5.24060499
3regulation of meiosis I (GO:0060631)5.08191655
4spindle assembly involved in mitosis (GO:0090307)5.06907279
5chaperone-mediated protein transport (GO:0072321)4.77858294
6establishment of protein localization to mitochondrial membrane (GO:0090151)4.52871806
7organelle disassembly (GO:1903008)4.44806969
8protein neddylation (GO:0045116)4.31177200
9rRNA modification (GO:0000154)4.24120317
10transcription elongation from RNA polymerase III promoter (GO:0006385)4.18573125
11termination of RNA polymerase III transcription (GO:0006386)4.18573125
12exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.12312811
13ribonucleoprotein complex disassembly (GO:0032988)4.09380809
14ATP synthesis coupled proton transport (GO:0015986)4.08888030
15energy coupled proton transport, down electrochemical gradient (GO:0015985)4.08888030
16nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.05755452
17microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.85819160
18maturation of 5.8S rRNA (GO:0000460)3.84816894
19synapsis (GO:0007129)3.75307251
20mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.69952958
21RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.68518692
22maturation of SSU-rRNA (GO:0030490)3.66006933
23cullin deneddylation (GO:0010388)3.61018441
24L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.57551245
25ribosomal small subunit assembly (GO:0000028)3.54808531
26regulation of DNA endoreduplication (GO:0032875)3.53414525
27regulation of response to tumor cell (GO:0002834)3.43884550
28positive regulation of response to tumor cell (GO:0002836)3.43884550
29positive regulation of immune response to tumor cell (GO:0002839)3.43884550
30regulation of immune response to tumor cell (GO:0002837)3.43884550
31positive regulation of muscle cell apoptotic process (GO:0010661)3.43000678
32rRNA processing (GO:0006364)3.40580659
33kynurenine metabolic process (GO:0070189)3.38312264
34rRNA metabolic process (GO:0016072)3.33866197
35tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.33162200
36RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.33162200
37water-soluble vitamin biosynthetic process (GO:0042364)3.33008334
38transcription elongation from RNA polymerase I promoter (GO:0006362)3.30122187
39tryptophan catabolic process (GO:0006569)3.29714372
40indole-containing compound catabolic process (GO:0042436)3.29714372
41indolalkylamine catabolic process (GO:0046218)3.29714372
42nucleobase biosynthetic process (GO:0046112)3.28583557
43DNA catabolic process, exonucleolytic (GO:0000738)3.28448961
44pseudouridine synthesis (GO:0001522)3.25220694
45protein K6-linked ubiquitination (GO:0085020)3.25081525
46rRNA methylation (GO:0031167)3.22441649
47protein deneddylation (GO:0000338)3.18833473
48DNA double-strand break processing (GO:0000729)3.18094924
49purine nucleobase biosynthetic process (GO:0009113)3.17842748
50postreplication repair (GO:0006301)3.15241128
51regulation of cellular amino acid metabolic process (GO:0006521)3.14866267
52ribosomal large subunit biogenesis (GO:0042273)3.14164988
53negative regulation of calcium ion transport into cytosol (GO:0010523)3.08533524
54positive regulation of DNA recombination (GO:0045911)3.08384897
55translesion synthesis (GO:0019985)3.07981699
56mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.06136743
57axoneme assembly (GO:0035082)3.03466447
58nucleotide transmembrane transport (GO:1901679)3.03360283
59termination of RNA polymerase I transcription (GO:0006363)3.03257768
60transcription initiation from RNA polymerase I promoter (GO:0006361)2.94416590
61negative regulation of DNA-dependent DNA replication (GO:2000104)2.94152008
62amino acid salvage (GO:0043102)2.91056936
63L-methionine salvage (GO:0071267)2.91056936
64L-methionine biosynthetic process (GO:0071265)2.91056936
65DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.88683786
66respiratory electron transport chain (GO:0022904)2.86251295
67electron transport chain (GO:0022900)2.86009621
68signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.85355413
69signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.85355413
70signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.85355413
71viral mRNA export from host cell nucleus (GO:0046784)2.85250370
72replication fork processing (GO:0031297)2.84410229
73negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.81952272
74negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.80783606
75protein prenylation (GO:0018342)2.80302086
76prenylation (GO:0097354)2.80302086
77signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.80045459
78intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.80045459
79mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.72154770
80mitochondrial respiratory chain complex I assembly (GO:0032981)2.72154770
81NADH dehydrogenase complex assembly (GO:0010257)2.72154770
82cytidine metabolic process (GO:0046087)2.70405118
83cytidine catabolic process (GO:0006216)2.70405118
84cytidine deamination (GO:0009972)2.70405118
85GTP biosynthetic process (GO:0006183)2.70113763
86rRNA catabolic process (GO:0016075)2.69817794
87preassembly of GPI anchor in ER membrane (GO:0016254)2.67473925
88transcription from RNA polymerase I promoter (GO:0006360)2.65603226
89inner mitochondrial membrane organization (GO:0007007)2.65562136
90signal peptide processing (GO:0006465)2.64349702
91aldehyde catabolic process (GO:0046185)2.63642117
92signal transduction involved in DNA damage checkpoint (GO:0072422)2.63317081
93signal transduction involved in DNA integrity checkpoint (GO:0072401)2.63317081
94signal transduction involved in cell cycle checkpoint (GO:0072395)2.61772075
95GPI anchor metabolic process (GO:0006505)2.61591271
96reciprocal meiotic recombination (GO:0007131)2.58953744
97reciprocal DNA recombination (GO:0035825)2.58953744
98formation of translation preinitiation complex (GO:0001731)2.58702725
99isotype switching (GO:0045190)2.57843852
100somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.57843852

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.14600246
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.12437002
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.83839376
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.65419124
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.64005454
6FLI1_27457419_Chip-Seq_LIVER_Mouse3.16001375
7VDR_22108803_ChIP-Seq_LS180_Human3.03932550
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.63776781
9ELK1_19687146_ChIP-ChIP_HELA_Human2.59022330
10PCGF2_27294783_Chip-Seq_ESCs_Mouse2.56916891
11VDR_23849224_ChIP-Seq_CD4+_Human2.50502689
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.45635582
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.32427729
14IGF1R_20145208_ChIP-Seq_DFB_Human2.23060729
15EWS_26573619_Chip-Seq_HEK293_Human2.22823050
16PCGF2_27294783_Chip-Seq_NPCs_Mouse2.21920855
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.17536766
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.15885475
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.08047764
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.01325722
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95915148
22E2F7_22180533_ChIP-Seq_HELA_Human1.95890019
23ZNF274_21170338_ChIP-Seq_K562_Hela1.88531986
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.85467542
25FOXP3_21729870_ChIP-Seq_TREG_Human1.84683583
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82289498
27ETS1_20019798_ChIP-Seq_JURKAT_Human1.73611955
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69756734
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.65077584
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.61925499
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57807078
32PADI4_21655091_ChIP-ChIP_MCF-7_Human1.57335701
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.56108514
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55985494
35P300_19829295_ChIP-Seq_ESCs_Human1.52460690
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.51598254
37SOX2_19829295_ChIP-Seq_ESCs_Human1.47264085
38NANOG_19829295_ChIP-Seq_ESCs_Human1.47264085
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.46154019
40TTF2_22483619_ChIP-Seq_HELA_Human1.43212428
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39342374
42EZH2_27294783_Chip-Seq_NPCs_Mouse1.39161196
43EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.37484638
44FOXA1_27270436_Chip-Seq_PROSTATE_Human1.37126918
45FOXA1_25329375_ChIP-Seq_VCAP_Human1.37126918
46ER_23166858_ChIP-Seq_MCF-7_Human1.36227269
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35852470
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34270991
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33517387
50CRX_20693478_ChIP-Seq_RETINA_Mouse1.32850759
51AUTS2_25519132_ChIP-Seq_293T-REX_Human1.28009576
52MYC_18940864_ChIP-ChIP_HL60_Human1.27197683
53FUS_26573619_Chip-Seq_HEK293_Human1.25885333
54CDX2_22108803_ChIP-Seq_LS180_Human1.24962848
55MYC_18358816_ChIP-ChIP_MESCs_Mouse1.23270853
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.19751062
57TP53_22573176_ChIP-Seq_HFKS_Human1.17510137
58GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17185774
59IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.16914266
60BP1_19119308_ChIP-ChIP_Hs578T_Human1.16716930
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16573897
62CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.16347297
63MYC_19030024_ChIP-ChIP_MESCs_Mouse1.16092892
64IRF8_22096565_ChIP-ChIP_GC-B_Human1.15156842
65FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14109672
66IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.14003348
67FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.13872690
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12752463
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11568112
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11396836
71ELK1_22589737_ChIP-Seq_MCF10A_Human1.10945087
72GABP_19822575_ChIP-Seq_HepG2_Human1.08641330
73GATA3_21878914_ChIP-Seq_MCF-7_Human1.05356301
74GATA3_26560356_Chip-Seq_TH2_Human1.04460772
75EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.04062862
76IRF8_21731497_ChIP-ChIP_J774_Mouse1.02961573
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.02419420
78STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01822643
79P53_22387025_ChIP-Seq_ESCs_Mouse1.00920401
80RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00220311
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99693660
82KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99414266
83SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98255326
84TCF4_22108803_ChIP-Seq_LS180_Human0.98149208
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96753387
86MYC_19079543_ChIP-ChIP_MESCs_Mouse0.96075398
87SMAD3_21741376_ChIP-Seq_EPCs_Human0.95679739
88STAT3_18555785_Chip-Seq_ESCs_Mouse0.95466230
89PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.95308328
90P300_18555785_Chip-Seq_ESCs_Mouse0.95028045
91CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94547600
92RBPJ_21746931_ChIP-Seq_IB4_Human0.94001075
93HOXB7_26014856_ChIP-Seq_BT474_Human0.93991935
94FLI1_21867929_ChIP-Seq_TH2_Mouse0.92915220
95SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92837862
96CMYC_18555785_Chip-Seq_ESCs_Mouse0.92059440
97OCT4_18555785_Chip-Seq_ESCs_Mouse0.91765270
98FOXH1_21741376_ChIP-Seq_EPCs_Human0.91470509
99SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.91096328
100AR_20517297_ChIP-Seq_VCAP_Human0.90162963

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue3.37415301
2MP0002102_abnormal_ear_morphology3.27540834
3MP0003195_calcinosis3.13506277
4MP0008875_abnormal_xenobiotic_pharmacok3.10780773
5MP0000569_abnormal_digit_pigmentation2.97139831
6MP0003183_abnormal_peptide_metabolism2.91589337
7MP0002163_abnormal_gland_morphology2.90087910
8MP0008058_abnormal_DNA_repair2.87484382
9MP0009379_abnormal_foot_pigmentation2.63374414
10MP0005645_abnormal_hypothalamus_physiol2.53275234
11MP0003806_abnormal_nucleotide_metabolis2.39624743
12MP0004381_abnormal_hair_follicle2.27985155
13MP0005075_abnormal_melanosome_morpholog2.20491191
14MP0004885_abnormal_endolymph2.17174973
15MP0002234_abnormal_pharynx_morphology2.11371878
16MP0003011_delayed_dark_adaptation2.09576729
17MP0003950_abnormal_plasma_membrane1.93216924
18MP0001835_abnormal_antigen_presentation1.93126182
19MP0003186_abnormal_redox_activity1.90697865
20MP0009785_altered_susceptibility_to1.88143338
21MP0002837_dystrophic_cardiac_calcinosis1.88017220
22MP0005671_abnormal_response_to1.87952265
23MP0002938_white_spotting1.85534584
24MP0005408_hypopigmentation1.79325306
25MP0008872_abnormal_physiological_respon1.77045965
26MP0003718_maternal_effect1.72418641
27MP0005174_abnormal_tail_pigmentation1.71185506
28MP0005646_abnormal_pituitary_gland1.66776810
29MP0006036_abnormal_mitochondrial_physio1.63458945
30MP0010094_abnormal_chromosome_stability1.61717518
31MP0006035_abnormal_mitochondrial_morpho1.57896421
32MP0002166_altered_tumor_susceptibility1.56368524
33MP0000685_abnormal_immune_system1.55287346
34MP0000372_irregular_coat_pigmentation1.54457420
35MP0005670_abnormal_white_adipose1.52846338
36MP0009697_abnormal_copulation1.43261720
37MP0008007_abnormal_cellular_replicative1.41866208
38MP0000427_abnormal_hair_cycle1.40965850
39MP0005379_endocrine/exocrine_gland_phen1.39624605
40MP0002148_abnormal_hypersensitivity_rea1.37738037
41MP0002160_abnormal_reproductive_system1.36245000
42MP0003786_premature_aging1.34492858
43MP0009764_decreased_sensitivity_to1.32127829
44MP0004084_abnormal_cardiac_muscle1.30800404
45MP0002095_abnormal_skin_pigmentation1.30078669
46MP0005389_reproductive_system_phenotype1.29209408
47MP0005171_absent_coat_pigmentation1.28497011
48MP0002006_tumorigenesis1.28163440
49MP0005551_abnormal_eye_electrophysiolog1.26327792
50MP0004145_abnormal_muscle_electrophysio1.24798604
51MP0005387_immune_system_phenotype1.22900969
52MP0001790_abnormal_immune_system1.22900969
53MP0001800_abnormal_humoral_immune1.22356981
54MP0003567_abnormal_fetal_cardiomyocyte1.19004618
55MP0005084_abnormal_gallbladder_morpholo1.16177565
56MP0006072_abnormal_retinal_apoptosis1.15587555
57MP0004742_abnormal_vestibular_system1.15086563
58MP0002396_abnormal_hematopoietic_system1.05007187
59MP0002138_abnormal_hepatobiliary_system1.04774423
60MP0004957_abnormal_blastocyst_morpholog1.04531435
61MP0001293_anophthalmia0.99201811
62MP0004215_abnormal_myocardial_fiber0.98879585
63MP0001501_abnormal_sleep_pattern0.98323519
64MP0009250_abnormal_appendicular_skeleto0.97630579
65MP0008775_abnormal_heart_ventricle0.95676672
66MP0000749_muscle_degeneration0.94510832
67MP0006292_abnormal_olfactory_placode0.90943551
68MP0008877_abnormal_DNA_methylation0.88787208
69MP0002876_abnormal_thyroid_physiology0.85783138
70MP0005360_urolithiasis0.85577287
71MP0001119_abnormal_female_reproductive0.85199991
72MP0000371_diluted_coat_color0.84868216
73MP0002452_abnormal_antigen_presenting0.84247833
74MP0003880_abnormal_central_pattern0.83563010
75MP0005332_abnormal_amino_acid0.83392303
76MP0002751_abnormal_autonomic_nervous0.83297987
77MP0001919_abnormal_reproductive_system0.81318425
78MP0000015_abnormal_ear_pigmentation0.80422999
79MP0002723_abnormal_immune_serum0.79695977
80MP0005410_abnormal_fertilization0.79231934
81MP0002282_abnormal_trachea_morphology0.79101899
82MP0005167_abnormal_blood-brain_barrier0.78732425
83MP0002420_abnormal_adaptive_immunity0.78670398
84MP0002127_abnormal_cardiovascular_syste0.78295545
85MP0001819_abnormal_immune_cell0.76689298
86MP0009333_abnormal_splenocyte_physiolog0.75779958
87MP0001764_abnormal_homeostasis0.73990428
88MP0001873_stomach_inflammation0.73763003
89MP0010386_abnormal_urinary_bladder0.71769281
90MP0005000_abnormal_immune_tolerance0.71268347
91MP0000465_gastrointestinal_hemorrhage0.67320046
92MP0004043_abnormal_pH_regulation0.66963952
93MP0005085_abnormal_gallbladder_physiolo0.64099092
94MP0001929_abnormal_gametogenesis0.64095193
95MP0003763_abnormal_thymus_physiology0.63574551
96MP0001986_abnormal_taste_sensitivity0.61920215
97MP0001502_abnormal_circadian_rhythm0.61667764
98MP0000716_abnormal_immune_system0.61255296
99MP0002398_abnormal_bone_marrow0.60173080
100MP0008873_increased_physiological_sensi0.58545621

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)4.14584132
2Acute necrotizing encephalopathy (HP:0006965)3.96185370
3Acute encephalopathy (HP:0006846)3.77941784
4Constricted visual fields (HP:0001133)3.69697297
5Increased CSF lactate (HP:0002490)3.67196685
6Mitochondrial inheritance (HP:0001427)3.55515919
7Increased hepatocellular lipid droplets (HP:0006565)3.48785252
8Retrobulbar optic neuritis (HP:0100654)3.40009071
9Optic neuritis (HP:0100653)3.40009071
10Hepatocellular necrosis (HP:0001404)3.34030268
11Lipid accumulation in hepatocytes (HP:0006561)3.30499646
12Abnormal mitochondria in muscle tissue (HP:0008316)3.22372528
13Progressive macrocephaly (HP:0004481)3.15954439
14Hepatic necrosis (HP:0002605)3.12904984
15Abnormal rod and cone electroretinograms (HP:0008323)3.09899367
16Absent/shortened dynein arms (HP:0200106)2.95543130
17Dynein arm defect of respiratory motile cilia (HP:0012255)2.95543130
18Cerebral hypomyelination (HP:0006808)2.94289015
19Increased serum lactate (HP:0002151)2.87311279
20Renal Fanconi syndrome (HP:0001994)2.83365540
21Orchitis (HP:0100796)2.82748569
22Abnormality of the renal cortex (HP:0011035)2.79053079
23Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.75199161
24Optic disc pallor (HP:0000543)2.70023460
25Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.68352845
26Congenital sensorineural hearing impairment (HP:0008527)2.57228619
27Colon cancer (HP:0003003)2.56916613
28Abnormality of the phalanges of the 2nd finger (HP:0009541)2.56537310
29Increased serum pyruvate (HP:0003542)2.54265635
30Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.53131829
31Cerebral edema (HP:0002181)2.51232038
32Pancreatic cysts (HP:0001737)2.49003293
33Congenital stationary night blindness (HP:0007642)2.45045706
34Hypoproteinemia (HP:0003075)2.44700479
35Myositis (HP:0100614)2.44338451
36Abnormality of the labia minora (HP:0012880)2.42113779
37Exertional dyspnea (HP:0002875)2.41090688
38Abnormality of midbrain morphology (HP:0002418)2.40364879
39Molar tooth sign on MRI (HP:0002419)2.40364879
40Pendular nystagmus (HP:0012043)2.39647360
41Oligodactyly (hands) (HP:0001180)2.38058232
42Hypoplasia of the uterus (HP:0000013)2.37329457
43Attenuation of retinal blood vessels (HP:0007843)2.36274525
44Progressive inability to walk (HP:0002505)2.34264922
45Increased corneal curvature (HP:0100692)2.33988948
46Keratoconus (HP:0000563)2.33988948
47Abnormality of the phalanges of the 5th finger (HP:0004213)2.32317749
48Renal cortical cysts (HP:0000803)2.29112977
49Keratoconjunctivitis sicca (HP:0001097)2.27248540
50Chronic bronchitis (HP:0004469)2.26685728
51Leukodystrophy (HP:0002415)2.26389894
52Hypokalemic alkalosis (HP:0001949)2.24773571
53Abnormality of glycolysis (HP:0004366)2.23467641
54Adactyly (HP:0009776)2.22520111
55CNS demyelination (HP:0007305)2.21203100
56Degeneration of anterior horn cells (HP:0002398)2.19109541
57Abnormality of the anterior horn cell (HP:0006802)2.19109541
58Poor head control (HP:0002421)2.18571855
59Keratoconjunctivitis (HP:0001096)2.17961908
60Decreased central vision (HP:0007663)2.16597012
61X-linked dominant inheritance (HP:0001423)2.16257881
62Type 2 muscle fiber atrophy (HP:0003554)2.14803462
63Abnormality of the renal collecting system (HP:0004742)2.10056176
64Hyperglycinemia (HP:0002154)2.09245496
65Respiratory failure (HP:0002878)2.08894106
66Abnormality of the renal medulla (HP:0100957)2.04637134
67Cerebral hemorrhage (HP:0001342)2.03999863
68Abnormality of macular pigmentation (HP:0008002)2.03883224
69Exercise intolerance (HP:0003546)2.03791081
70Respiratory difficulties (HP:0002880)2.02342038
71Metabolic alkalosis (HP:0200114)2.01064308
72True hermaphroditism (HP:0010459)2.00039418
73Supernumerary spleens (HP:0009799)1.99523010
74Keratitis (HP:0000491)1.96388523
75IgG deficiency (HP:0004315)1.96012069
76Lactic acidosis (HP:0003128)1.95697768
77Dyschromatopsia (HP:0007641)1.95630487
78Abnormality of renal resorption (HP:0011038)1.95203533
79Nephronophthisis (HP:0000090)1.95046659
80CNS hypomyelination (HP:0003429)1.93798600
81Inability to walk (HP:0002540)1.92454363
82Duplicated collecting system (HP:0000081)1.91750034
83Lethargy (HP:0001254)1.91535602
84Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.90930771
85Decreased activity of mitochondrial respiratory chain (HP:0008972)1.90930771
86Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.90858537
87Decreased electroretinogram (ERG) amplitude (HP:0000654)1.90737703
88Abnormal respiratory motile cilium morphology (HP:0005938)1.90245985
89Abnormal respiratory epithelium morphology (HP:0012253)1.90245985
90Reticulocytopenia (HP:0001896)1.90046029
91Abnormality of DNA repair (HP:0003254)1.88681377
92Oral leukoplakia (HP:0002745)1.88665841
93Aplasia/hypoplasia of the uterus (HP:0008684)1.88609981
94Pancytopenia (HP:0001876)1.88145252
953-Methylglutaconic aciduria (HP:0003535)1.87213443
96Methylmalonic acidemia (HP:0002912)1.86244804
97Abnormal respiratory motile cilium physiology (HP:0012261)1.85692300
98Hemoptysis (HP:0002105)1.85208824
99Aplastic anemia (HP:0001915)1.84951367
100Gangrene (HP:0100758)1.82840123

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K25.08526687
2TAOK33.71552997
3VRK23.36317361
4BUB12.97233719
5NUAK12.72646511
6EIF2AK32.72072051
7TAF12.40783787
8MST42.40473184
9MAP3K122.33098684
10STK392.20975002
11PINK12.06437562
12OXSR12.05208930
13ZAK1.98746064
14MKNK21.94451716
15TSSK61.94254136
16STK38L1.93973006
17NEK11.84901456
18EIF2AK11.77367711
19TLK11.76071609
20MAP2K61.75917676
21BMPR21.70831298
22VRK11.69721112
23PBK1.68451167
24WNK31.58859073
25FLT31.50278014
26SIK31.50207295
27PLK31.48986128
28PLK41.44759996
29CDK81.43571169
30WNK41.37901873
31GRK11.37134800
32BMPR1B1.36696176
33MKNK11.30985952
34EIF2AK21.29393198
35STK241.28369258
36ADRBK21.21118129
37ACVR1B1.14872528
38ERBB31.12646470
39STK31.03314502
40PLK21.00855549
41TESK10.95052375
42CCNB10.93559187
43MYLK0.91649038
44IKBKB0.90072039
45TRIM280.84373913
46TXK0.82766720
47PLK10.80270008
48MAPK130.79438491
49TEC0.79082152
50BCR0.78872005
51FRK0.76636549
52TGFBR10.76565780
53WEE10.75519506
54GRK50.75409864
55TNIK0.74837884
56MAPKAPK50.71376910
57DAPK10.66293031
58CSNK1G30.65196154
59MAP4K10.62085522
60SRPK10.59640322
61TIE10.58802859
62CSNK1A1L0.58251549
63ITK0.57225203
64CSNK1G10.56295591
65CSF1R0.55960163
66INSRR0.53863813
67PIK3CG0.51982056
68DYRK20.51634625
69KIT0.51225138
70FGFR10.50676679
71CSNK1G20.47642804
72TGFBR20.46964758
73NEK20.45204896
74NME10.44232341
75TRPM70.43980047
76DAPK20.40424545
77ERBB40.39499965
78IGF1R0.37110893
79AURKA0.37095258
80LATS10.35153530
81MAP3K110.35094410
82STK160.33925523
83CSNK1A10.33145762
84MAPKAPK30.32894291
85CHEK20.32700065
86PASK0.32613669
87PRKCG0.31994724
88DAPK30.31615369
89KDR0.31211988
90TTK0.30764850
91ATR0.30551289
92AURKB0.30087770
93CSNK2A20.29378062
94NLK0.28817382
95PRKCE0.27930797
96CSNK2A10.27782057
97PAK30.27579512
98PRKG10.27478411
99GSK3A0.27451636
100PHKG20.25411259

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.67416364
2Oxidative phosphorylation_Homo sapiens_hsa001902.94452800
3Ribosome_Homo sapiens_hsa030102.74289856
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.70261479
5One carbon pool by folate_Homo sapiens_hsa006702.68896395
6Protein export_Homo sapiens_hsa030602.62117079
7RNA polymerase_Homo sapiens_hsa030202.56646520
8Propanoate metabolism_Homo sapiens_hsa006402.34443565
9Homologous recombination_Homo sapiens_hsa034402.31337541
10Asthma_Homo sapiens_hsa053102.29382694
11Parkinsons disease_Homo sapiens_hsa050122.29300904
12RNA degradation_Homo sapiens_hsa030182.17295165
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.03471154
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.00916344
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.98555055
16Graft-versus-host disease_Homo sapiens_hsa053321.93888487
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.88436323
18Basal transcription factors_Homo sapiens_hsa030221.85113289
19Allograft rejection_Homo sapiens_hsa053301.81467248
20RNA transport_Homo sapiens_hsa030131.68206303
21Autoimmune thyroid disease_Homo sapiens_hsa053201.66429422
22Linoleic acid metabolism_Homo sapiens_hsa005911.58877746
23Huntingtons disease_Homo sapiens_hsa050161.54126517
24Non-homologous end-joining_Homo sapiens_hsa034501.52626566
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.52066220
26Alzheimers disease_Homo sapiens_hsa050101.48128646
27Antigen processing and presentation_Homo sapiens_hsa046121.46559614
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.40481569
29Pyrimidine metabolism_Homo sapiens_hsa002401.40154814
30Nucleotide excision repair_Homo sapiens_hsa034201.39978536
31Type I diabetes mellitus_Homo sapiens_hsa049401.39371199
32DNA replication_Homo sapiens_hsa030301.38580513
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.37938890
34Vitamin B6 metabolism_Homo sapiens_hsa007501.37280734
35Fatty acid elongation_Homo sapiens_hsa000621.35734875
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.27539234
37Mismatch repair_Homo sapiens_hsa034301.26746962
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.25141659
39Sulfur metabolism_Homo sapiens_hsa009201.24534794
40Fanconi anemia pathway_Homo sapiens_hsa034601.18308978
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.06867314
42Tryptophan metabolism_Homo sapiens_hsa003801.04492745
43Primary immunodeficiency_Homo sapiens_hsa053401.02673392
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.02162206
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.00804020
46Spliceosome_Homo sapiens_hsa030401.00560446
47Pyruvate metabolism_Homo sapiens_hsa006200.98019010
48Purine metabolism_Homo sapiens_hsa002300.95166764
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.93202709
50Ether lipid metabolism_Homo sapiens_hsa005650.88310694
51Cardiac muscle contraction_Homo sapiens_hsa042600.85510967
52Base excision repair_Homo sapiens_hsa034100.84620213
53Glutathione metabolism_Homo sapiens_hsa004800.80524052
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80370889
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78704602
56Chemical carcinogenesis_Homo sapiens_hsa052040.76849478
57NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76578592
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76033747
59Rheumatoid arthritis_Homo sapiens_hsa053230.75682965
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75370215
61Arachidonic acid metabolism_Homo sapiens_hsa005900.73826865
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70527161
63Phototransduction_Homo sapiens_hsa047440.70478346
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65983492
65Retinol metabolism_Homo sapiens_hsa008300.65131532
66Nitrogen metabolism_Homo sapiens_hsa009100.62575281
67Hematopoietic cell lineage_Homo sapiens_hsa046400.60736108
68Metabolic pathways_Homo sapiens_hsa011000.58389667
69p53 signaling pathway_Homo sapiens_hsa041150.58352007
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58345266
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56892129
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53527259
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53162376
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.51603680
75Systemic lupus erythematosus_Homo sapiens_hsa053220.50720511
76Salivary secretion_Homo sapiens_hsa049700.50627587
77Starch and sucrose metabolism_Homo sapiens_hsa005000.49321405
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48662711
79Collecting duct acid secretion_Homo sapiens_hsa049660.48508437
80Caffeine metabolism_Homo sapiens_hsa002320.47978098
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46221383
82Butanoate metabolism_Homo sapiens_hsa006500.46125285
83Folate biosynthesis_Homo sapiens_hsa007900.46033612
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.43473626
85Nicotine addiction_Homo sapiens_hsa050330.40915431
86Fatty acid degradation_Homo sapiens_hsa000710.39417838
87Epstein-Barr virus infection_Homo sapiens_hsa051690.38552501
88Glycerolipid metabolism_Homo sapiens_hsa005610.38547363
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38353701
90Fat digestion and absorption_Homo sapiens_hsa049750.38093283
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36781085
92Circadian rhythm_Homo sapiens_hsa047100.36286529
93beta-Alanine metabolism_Homo sapiens_hsa004100.35909159
94Carbon metabolism_Homo sapiens_hsa012000.35579695
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35186416
96Legionellosis_Homo sapiens_hsa051340.34340404
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34100139
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33333480
99Olfactory transduction_Homo sapiens_hsa047400.32842341
100Peroxisome_Homo sapiens_hsa041460.31714814

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