ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	4.63945848
2	proteasome assembly (GO:0043248)	4.26624348
3	tolerance induction (GO:0002507)	4.23203637
4	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.16647338
5	regulation of cellular amino acid metabolic process (GO:0006521)	3.94203768
6	protein deneddylation (GO:0000338)	3.94088970
7	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.86110099
8	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.79332441
9	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.75216092
10	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.75216092
11	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.75216092
12	regulation of chronic inflammatory response (GO:0002676)	3.74678387
13	ribosome assembly (GO:0042255)	3.74035208
14	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.70063385
15	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.70063385
16	cullin deneddylation (GO:0010388)	3.66363638
17	negative regulation of thymocyte apoptotic process (GO:0070244)	3.64307895
18	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.63347785
19	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.61358621
20	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.61358621
21	cellular response to interleukin-15 (GO:0071350)	3.61068385
22	rRNA modification (GO:0000154)	3.60936112
23	sleep (GO:0030431)	3.57050700
24	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.54082693
25	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.45742674
26	negative regulation of ligase activity (GO:0051352)	3.45742674
27	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	3.44501335
28	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.40451333
29	AMP metabolic process (GO:0046033)	3.38943185
30	response to gravity (GO:0009629)	3.35630733
31	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.33535170
32	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.28084542
33	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	3.21209720
34	adenosine metabolic process (GO:0046085)	3.17936037
35	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.07170970
36	positive regulation of defense response to virus by host (GO:0002230)	3.05390933
37	response to interferon-beta (GO:0035456)	3.05283551
38	rRNA methylation (GO:0031167)	3.02309201
39	antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)	3.00881134
40	CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)	3.00105042
41	T-helper cell differentiation (GO:0042093)	3.00105042
42	T cell differentiation involved in immune response (GO:0002292)	2.99623640
43	alpha-beta T cell differentiation involved in immune response (GO:0002293)	2.99623640
44	alpha-beta T cell activation involved in immune response (GO:0002287)	2.99623640
45	positive regulation of ligase activity (GO:0051351)	2.99355189
46	L-methionine salvage (GO:0071267)	2.99180208
47	L-methionine biosynthetic process (GO:0071265)	2.99180208
48	amino acid salvage (GO:0043102)	2.99180208
49	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.99076622
50	response to interleukin-15 (GO:0070672)	2.96902583
51	establishment of integrated proviral latency (GO:0075713)	2.96216087
52	positive regulation of cell cycle arrest (GO:0071158)	2.94850137
53	regulation of thymocyte apoptotic process (GO:0070243)	2.92834985
54	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	2.89031494
55	cytidine deamination (GO:0009972)	2.88943789
56	cytidine metabolic process (GO:0046087)	2.88943789
57	cytidine catabolic process (GO:0006216)	2.88943789
58	DNA catabolic process, exonucleolytic (GO:0000738)	2.87725332
59	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.86755839
60	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.86080112
61	establishment of viral latency (GO:0019043)	2.85746403
62	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.85733976
63	regulation of defense response to virus by host (GO:0050691)	2.83312736
64	GTP biosynthetic process (GO:0006183)	2.82327958
65	pseudouridine synthesis (GO:0001522)	2.80912965
66	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.79474465
67	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.79474465
68	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.78485574
69	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.78485574
70	NADH dehydrogenase complex assembly (GO:0010257)	2.78485574
71	positive regulation of prostaglandin secretion (GO:0032308)	2.77160260
72	regulation of isotype switching to IgG isotypes (GO:0048302)	2.75600772
73	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.74792700
74	termination of RNA polymerase III transcription (GO:0006386)	2.74792700
75	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	2.70890527
76	ATP synthesis coupled proton transport (GO:0015986)	2.69545889
77	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.69545889
78	regulation of cellular amine metabolic process (GO:0033238)	2.69224173
79	regulation of T cell mediated cytotoxicity (GO:0001914)	2.68251529
80	preassembly of GPI anchor in ER membrane (GO:0016254)	2.64602723
81	water-soluble vitamin biosynthetic process (GO:0042364)	2.61972784
82	protein maturation by protein folding (GO:0022417)	2.61811422
83	chaperone mediated protein folding requiring cofactor (GO:0051085)	2.60076180
84	protein complex biogenesis (GO:0070271)	2.55855492
85	negative regulation of T cell apoptotic process (GO:0070233)	2.55258818
86	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.53302412
87	isotype switching (GO:0045190)	2.53302412
88	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.53302412
89	folic acid-containing compound biosynthetic process (GO:0009396)	2.52549392
90	termination of RNA polymerase I transcription (GO:0006363)	2.51387698
91	regulation of ubiquitin-protein transferase activity (GO:0051438)	2.49513838
92	mitochondrial respiratory chain complex assembly (GO:0033108)	2.49059138
93	regulation of cell cycle arrest (GO:0071156)	2.49010654
94	regulation of translational termination (GO:0006449)	2.48361978
95	negative regulation of protein ubiquitination (GO:0031397)	2.47995749
96	signal transduction in response to DNA damage (GO:0042770)	2.45969083
97	regulation of ligase activity (GO:0051340)	2.45561030
98	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.44881293
99	maturation of 5.8S rRNA (GO:0000460)	2.44876289
100	protein K6-linked ubiquitination (GO:0085020)	2.44722688

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.65318415
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.39038873
3	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.57940212
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.52924887
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.48021927
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.23955671
7	VDR_23849224_ChIP-Seq_CD4+_Human	2.94449389
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.83776944
9	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.76666073
10	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.63521361
11	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.50468541
12	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.42576969
13	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.40737147
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.37566275
15	FOXP3_21729870_ChIP-Seq_TREG_Human	2.36979010
16	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.36407844
17	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.35157267
18	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.32167575
19	ELK1_19687146_ChIP-ChIP_HELA_Human	2.31498188
20	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.14831061
21	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.14230775
22	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.13297075
23	E2F7_22180533_ChIP-Seq_HELA_Human	2.12238820
24	DCP1A_22483619_ChIP-Seq_HELA_Human	2.10490977
25	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.94135725
26	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.93129760
27	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.90363451
28	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.86739923
29	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.86126002
30	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.82997141
31	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.80592198
32	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.80376150
33	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.77311206
34	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.76945443
35	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.75213052
36	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.74411304
37	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.73150713
38	MYB_26560356_Chip-Seq_TH2_Human	1.71159510
39	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.70114258
40	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.65341280
41	GABP_19822575_ChIP-Seq_HepG2_Human	1.64849155
42	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.64205295
43	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.64098144
44	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.61568043
45	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.61246876
46	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.58624026
47	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.58618676
48	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.54772466
49	ZNF274_21170338_ChIP-Seq_K562_Hela	1.53559711
50	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.53360268
51	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.50095498
52	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.49563306
53	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.49291085
54	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.49239213
55	GATA3_26560356_Chip-Seq_TH2_Human	1.49008941
56	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.46031347
57	RUNX_20019798_ChIP-Seq_JUKART_Human	1.43857706
58	XRN2_22483619_ChIP-Seq_HELA_Human	1.43132640
59	TTF2_22483619_ChIP-Seq_HELA_Human	1.40722228
60	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.39871923
61	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.38396884
62	MYC_18940864_ChIP-ChIP_HL60_Human	1.36307031
63	VDR_22108803_ChIP-Seq_LS180_Human	1.36169712
64	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.32070680
65	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.29480137
66	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.25230130
67	SPI1_23547873_ChIP-Seq_NB4_Human	1.24934963
68	CIITA_25753668_ChIP-Seq_RAJI_Human	1.22806162
69	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.22687840
70	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.20959287
71	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.20920095
72	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.19679630
73	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.17832331
74	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.10473468
75	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.10432848
76	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.10241476
77	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.09574151
78	MYB_26560356_Chip-Seq_TH1_Human	1.09180575
79	IRF1_19129219_ChIP-ChIP_H3396_Human	1.08264017
80	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.06240946
81	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.06206338
82	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.06147431
83	KDM5A_27292631_Chip-Seq_BREAST_Human	0.99503367
84	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.99314430
85	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.99209495
86	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.96280810
87	GATA3_27048872_Chip-Seq_THYMUS_Human	0.95004394
88	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.94982648
89	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.92115146
90	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.90762142
91	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.89947408
92	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	0.89710332
93	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	0.87972687
94	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.86533294
95	AR_20517297_ChIP-Seq_VCAP_Human	0.84759620
96	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.84591444
97	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.84042574
98	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.83390825
99	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.83390825
100	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.81002882

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003436_decreased_susceptibility_to	3.50923579
2	MP0003950_abnormal_plasma_membrane	3.45731478
3	MP0000685_abnormal_immune_system	3.44662640
4	MP0001835_abnormal_antigen_presentation	3.33521052
5	MP0005671_abnormal_response_to	3.24697814
6	MP0002166_altered_tumor_susceptibility	2.71015463
7	MP0002006_tumorigenesis	2.68732750
8	MP0002148_abnormal_hypersensitivity_rea	2.67657616
9	MP0003763_abnormal_thymus_physiology	2.44426901
10	MP0009785_altered_susceptibility_to	2.42627759
11	MP0005000_abnormal_immune_tolerance	2.41900303
12	MP0001800_abnormal_humoral_immune	2.18411736
13	MP0001790_abnormal_immune_system	2.11221391
14	MP0005387_immune_system_phenotype	2.11221391
15	MP0003693_abnormal_embryo_hatching	2.01100980
16	MP0009333_abnormal_splenocyte_physiolog	2.00697150
17	MP0003786_premature_aging	1.97767490
18	MP0008875_abnormal_xenobiotic_pharmacok	1.96007345
19	MP0002723_abnormal_immune_serum	1.95193889
20	MP0001873_stomach_inflammation	1.94605484
21	MP0002452_abnormal_antigen_presenting	1.90117334
22	MP0005360_urolithiasis	1.87848245
23	MP0003724_increased_susceptibility_to	1.83585881
24	MP0010094_abnormal_chromosome_stability	1.82841386
25	MP0006072_abnormal_retinal_apoptosis	1.80479858
26	MP0003806_abnormal_nucleotide_metabolis	1.80253311
27	MP0004147_increased_porphyrin_level	1.79636673
28	MP0001853_heart_inflammation	1.78748462
29	MP0001819_abnormal_immune_cell	1.78277236
30	MP0002138_abnormal_hepatobiliary_system	1.78033109
31	MP0002420_abnormal_adaptive_immunity	1.76337039
32	MP0002877_abnormal_melanocyte_morpholog	1.75949329
33	MP0002933_joint_inflammation	1.69783816
34	MP0001533_abnormal_skeleton_physiology	1.66067717
35	MP0002876_abnormal_thyroid_physiology	1.54978725
36	MP0003718_maternal_effect	1.52057534
37	MP0009764_decreased_sensitivity_to	1.51497061
38	MP0010155_abnormal_intestine_physiology	1.48016971
39	MP0008058_abnormal_DNA_repair	1.45757699
40	MP0004957_abnormal_blastocyst_morpholog	1.45738253
41	MP0005025_abnormal_response_to	1.42931930
42	MP0005165_increased_susceptibility_to	1.40408503
43	MP0002398_abnormal_bone_marrow	1.40399104
44	MP0008007_abnormal_cellular_replicative	1.38929693
45	MP0001845_abnormal_inflammatory_respons	1.35896864
46	MP0002722_abnormal_immune_system	1.33274246
47	MP0000716_abnormal_immune_system	1.33140508
48	MP0000689_abnormal_spleen_morphology	1.32899376
49	MP0001243_abnormal_dermal_layer	1.32554870
50	MP0004947_skin_inflammation	1.31942759
51	MP0002419_abnormal_innate_immunity	1.31752043
52	MP0002405_respiratory_system_inflammati	1.31518134
53	MP0008872_abnormal_physiological_respon	1.28873132
54	MP0005075_abnormal_melanosome_morpholog	1.27354257
55	MP0002429_abnormal_blood_cell	1.21240447
56	MP0000703_abnormal_thymus_morphology	1.19263703
57	MP0003195_calcinosis	1.19012094
58	MP0003866_abnormal_defecation	1.18853726
59	MP0009697_abnormal_copulation	1.18836859
60	MP0002019_abnormal_tumor_incidence	1.13295453
61	MP0004782_abnormal_surfactant_physiolog	1.12980347
62	MP0001542_abnormal_bone_strength	1.10111910
63	MP0003186_abnormal_redox_activity	1.09578149
64	MP0008469_abnormal_protein_level	1.09201025
65	MP0006036_abnormal_mitochondrial_physio	1.08527776
66	MP0002009_preneoplasia	1.07778110
67	MP0000465_gastrointestinal_hemorrhage	1.02631539
68	MP0005084_abnormal_gallbladder_morpholo	1.00834647
69	MP0008775_abnormal_heart_ventricle	0.98720188
70	MP0002102_abnormal_ear_morphology	0.96600734
71	MP0006035_abnormal_mitochondrial_morpho	0.96374365
72	MP0001881_abnormal_mammary_gland	0.94347110
73	MP0003111_abnormal_nucleus_morphology	0.94288025
74	MP0001919_abnormal_reproductive_system	0.92013308
75	MP0004145_abnormal_muscle_electrophysio	0.90410655
76	MP0000858_altered_metastatic_potential	0.87149489
77	MP0006054_spinal_hemorrhage	0.85355004
78	MP0003638_abnormal_response/metabolism_	0.83386269
79	MP0000013_abnormal_adipose_tissue	0.83176999
80	MP0005319_abnormal_enzyme/_coenzyme	0.82632798
81	MP0005390_skeleton_phenotype	0.82232451
82	MP0003656_abnormal_erythrocyte_physiolo	0.80539240
83	MP0003252_abnormal_bile_duct	0.79915928
84	MP0010368_abnormal_lymphatic_system	0.79378202
85	MP0001501_abnormal_sleep_pattern	0.77624040
86	MP0005464_abnormal_platelet_physiology	0.76431490
87	MP0003077_abnormal_cell_cycle	0.75821022
88	MP0000490_abnormal_crypts_of	0.75284654
89	MP0000358_abnormal_cell_content/	0.73640192
90	MP0006082_CNS_inflammation	0.72702438
91	MP0008877_abnormal_DNA_methylation	0.72230554
92	MP0002163_abnormal_gland_morphology	0.70844511
93	MP0000627_abnormal_mammary_gland	0.70507108
94	MP0003045_fibrosis	0.69606464
95	MP0000647_abnormal_sebaceous_gland	0.68832896
96	MP0003315_abnormal_perineum_morphology	0.67984903
97	MP0001216_abnormal_epidermal_layer	0.66701778
98	MP0005389_reproductive_system_phenotype	0.66334753
99	MP0003075_altered_response_to	0.65287051
100	MP0003448_altered_tumor_morphology	0.64353783

Predicted human phenotypes

Rank	Gene Set	Z-score
1	IgG deficiency (HP:0004315)	4.58808369
2	Elevated erythrocyte sedimentation rate (HP:0003565)	4.28484821
3	Stomatitis (HP:0010280)	4.08182681
4	Abnormality of T cell physiology (HP:0011840)	3.71446543
5	Increased serum pyruvate (HP:0003542)	3.59618181
6	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.50314897
7	Abnormality of alanine metabolism (HP:0010916)	3.50314897
8	Hyperalaninemia (HP:0003348)	3.50314897
9	Hepatocellular necrosis (HP:0001404)	3.47162298
10	Increased CSF lactate (HP:0002490)	3.26379601
11	Abnormality of glycolysis (HP:0004366)	3.24725007
12	Mitochondrial inheritance (HP:0001427)	3.24684502
13	Hepatic necrosis (HP:0002605)	3.19681768
14	Renal cortical cysts (HP:0000803)	3.13795102
15	Increased serum lactate (HP:0002151)	3.11319652
16	Acute necrotizing encephalopathy (HP:0006965)	3.08744365
17	Abnormality of T cells (HP:0002843)	2.99559019
18	Prostate neoplasm (HP:0100787)	2.94967969
19	Congenital, generalized hypertrichosis (HP:0004540)	2.89209639
20	Abnormality of the anterior horn cell (HP:0006802)	2.86085158
21	Degeneration of anterior horn cells (HP:0002398)	2.86085158
22	Abnormal mitochondria in muscle tissue (HP:0008316)	2.80674993
23	Hypoproteinemia (HP:0003075)	2.79833491
24	Acute encephalopathy (HP:0006846)	2.73738071
25	Severe combined immunodeficiency (HP:0004430)	2.66893155
26	Increased hepatocellular lipid droplets (HP:0006565)	2.62746372
27	Rough bone trabeculation (HP:0100670)	2.62550801
28	Tongue fasciculations (HP:0001308)	2.58337461
29	Aplasia/hypoplasia of the uterus (HP:0008684)	2.57799214
30	IgM deficiency (HP:0002850)	2.56937177
31	Lipid accumulation in hepatocytes (HP:0006561)	2.54890601
32	Pustule (HP:0200039)	2.53196064
33	Abnormality of the renal cortex (HP:0011035)	2.52623445
34	Ureteral duplication (HP:0000073)	2.50661386
35	Hypoplasia of the uterus (HP:0000013)	2.49029284
36	Duplicated collecting system (HP:0000081)	2.48701428
37	Abnormality of B cell number (HP:0010975)	2.44468222
38	Abnormality of the prostate (HP:0008775)	2.42906745
39	Stomach cancer (HP:0012126)	2.42688539
40	Progressive macrocephaly (HP:0004481)	2.42462611
41	Delayed CNS myelination (HP:0002188)	2.37511492
42	Type 2 muscle fiber atrophy (HP:0003554)	2.37137800
43	Pancytopenia (HP:0001876)	2.36758946
44	Lactic acidosis (HP:0003128)	2.35831255
45	Abnormal protein glycosylation (HP:0012346)	2.31750154
46	Abnormal glycosylation (HP:0012345)	2.31750154
47	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.31750154
48	Abnormal protein N-linked glycosylation (HP:0012347)	2.31750154
49	Eosinophilia (HP:0001880)	2.29607500
50	Abnormality of the pons (HP:0007361)	2.29520326
51	Abnormality of T cell number (HP:0011839)	2.27508459
52	Opisthotonus (HP:0002179)	2.26946097
53	Type I transferrin isoform profile (HP:0003642)	2.25734741
54	Cerebral edema (HP:0002181)	2.25103137
55	Glucose intolerance (HP:0000833)	2.24946596
56	Abnormality of the distal phalanges of the toes (HP:0010182)	2.24403301
57	Entropion (HP:0000621)	2.20528797
58	Increased IgM level (HP:0003496)	2.20346430
59	Reduced subcutaneous adipose tissue (HP:0003758)	2.19281456
60	Conical tooth (HP:0000698)	2.19105510
61	Exercise intolerance (HP:0003546)	2.18847031
62	Abnormality of eosinophils (HP:0001879)	2.17779149
63	Granulocytopenia (HP:0001913)	2.17338494
64	T lymphocytopenia (HP:0005403)	2.14995515
65	Constricted visual fields (HP:0001133)	2.14498584
66	Panhypogammaglobulinemia (HP:0003139)	2.14097534
67	Abnormality of the renal collecting system (HP:0004742)	2.13816734
68	B lymphocytopenia (HP:0010976)	2.13532181
69	Muscle fiber atrophy (HP:0100295)	2.12849934
70	Abnormal spermatogenesis (HP:0008669)	2.10456945
71	Testicular atrophy (HP:0000029)	2.08860996
72	Muscle fibrillation (HP:0010546)	2.08412443
73	Autoimmune hemolytic anemia (HP:0001890)	2.08057760
74	Reduced antithrombin III activity (HP:0001976)	2.07779610
75	Chronic diarrhea (HP:0002028)	2.07032174
76	Combined immunodeficiency (HP:0005387)	2.05276633
77	IgA deficiency (HP:0002720)	2.05215834
78	Sparse eyelashes (HP:0000653)	2.04955472
79	Respiratory failure (HP:0002878)	1.99666329
80	Neutropenia (HP:0001875)	1.98342460
81	Myositis (HP:0100614)	1.95815782
82	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.91316158
83	Pulmonary infiltrates (HP:0002113)	1.91110953
84	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.90999277
85	Renal Fanconi syndrome (HP:0001994)	1.86188841
86	Rhabdomyolysis (HP:0003201)	1.85214185
87	Facial diplegia (HP:0001349)	1.84261071
88	Palpitations (HP:0001962)	1.83790662
89	Brittle hair (HP:0002299)	1.83380905
90	Abnormal trabecular bone morphology (HP:0100671)	1.83368879
91	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.83139270
92	Pulmonary fibrosis (HP:0002206)	1.82454766
93	Exertional dyspnea (HP:0002875)	1.79345254
94	Lethargy (HP:0001254)	1.79135453
95	Increased intramyocellular lipid droplets (HP:0012240)	1.78708940
96	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.77547113
97	Premature rupture of membranes (HP:0001788)	1.77546332
98	Optic disc pallor (HP:0000543)	1.75853753
99	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.73118825
100	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.73118825

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	5.09000202
2	TESK2	3.21763433
3	TAOK3	2.97181633
4	TXK	2.90116030
5	BUB1	2.84968263
6	TLK1	2.60775258
7	ZAK	2.40292749
8	CDK8	2.39345470
9	TSSK6	2.28386527
10	MAP3K14	2.27973067
11	VRK1	2.23656370
12	MST4	2.05301370
13	TESK1	1.99080817
14	EIF2AK3	1.98664678
15	EIF2AK2	1.93221644
16	NUAK1	1.92689960
17	EIF2AK1	1.87944428
18	MAP2K2	1.76736711
19	NEK1	1.73838497
20	DAPK1	1.64811112
21	MAPKAPK3	1.63667058
22	IKBKB	1.59634250
23	STK16	1.54486259
24	LIMK1	1.50231206
25	CAMKK2	1.47965369
26	GRK6	1.47083011
27	MAP4K2	1.42563497
28	PBK	1.36693785
29	WNK4	1.32336661
30	KDR	1.31692402
31	SRPK1	1.24707183
32	TAF1	1.23740943
33	NME2	1.23304411
34	PLK3	1.23227051
35	MAP3K12	1.22451391
36	BCKDK	1.22428779
37	SCYL2	1.21828117
38	EPHA2	1.19463945
39	MUSK	1.14985784
40	MAP4K1	1.14574461
41	TBK1	1.11238757
42	IKBKE	1.10873267
43	ITK	1.09586968
44	ADRBK2	1.07849820
45	BMPR1B	1.06516465
46	STK10	1.04797964
47	KIT	0.95429055
48	TEC	0.95080421
49	MOS	0.91126668
50	TRIM28	0.88036764
51	PHKG2	0.87899495
52	PHKG1	0.87899495
53	PLK2	0.86660638
54	CCNB1	0.86308042
55	FLT3	0.85048855
56	MAPKAPK5	0.84469659
57	CSNK1G3	0.84371784
58	NME1	0.82073374
59	MYLK	0.80810733
60	TGFBR1	0.80648838
61	GRK1	0.76301310
62	CSNK1A1L	0.75309816
63	IRAK3	0.73986424
64	STK39	0.69155196
65	PDK2	0.67890687
66	GRK5	0.67888623
67	JAK3	0.65233859
68	PIK3CG	0.64977343
69	PRKCI	0.64384736
70	PAK4	0.60527899
71	CDK7	0.58084326
72	SYK	0.57870082
73	CDK9	0.55654945
74	SMG1	0.55608378
75	ARAF	0.53253849
76	JAK1	0.53198276
77	AURKB	0.53047583
78	PTK2B	0.52467708
79	CDK4	0.51722052
80	CSNK1G1	0.49121081
81	CHUK	0.48969129
82	PIM2	0.48937668
83	CSNK1G2	0.47070798
84	SIK3	0.46982077
85	ILK	0.45714686
86	PLK4	0.45030852
87	BMPR2	0.44842341
88	LCK	0.44773479
89	ZAP70	0.43132977
90	BRSK2	0.42487745
91	RPS6KA5	0.40878250
92	RPS6KA4	0.39272077
93	CSF1R	0.38548199
94	OXSR1	0.37983713
95	MAPKAPK2	0.37245478
96	GRK7	0.37131994
97	AURKA	0.36633793
98	DAPK3	0.35204164
99	ERBB3	0.34878729
100	MAP2K6	0.33695920

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	5.47797886
2	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.83615273
3	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.63124782
4	Allograft rejection_Homo sapiens_hsa05330	2.47081321
5	Protein export_Homo sapiens_hsa03060	2.31275919
6	Asthma_Homo sapiens_hsa05310	2.30931226
7	Primary immunodeficiency_Homo sapiens_hsa05340	2.19695701
8	RNA polymerase_Homo sapiens_hsa03020	2.18753600
9	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.18062553
10	Graft-versus-host disease_Homo sapiens_hsa05332	2.17952178
11	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.16729447
12	DNA replication_Homo sapiens_hsa03030	2.12861487
13	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.99423592
14	Mismatch repair_Homo sapiens_hsa03430	1.89086855
15	Oxidative phosphorylation_Homo sapiens_hsa00190	1.82604269
16	One carbon pool by folate_Homo sapiens_hsa00670	1.82123612
17	Antigen processing and presentation_Homo sapiens_hsa04612	1.80746848
18	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.77346989
19	Pyrimidine metabolism_Homo sapiens_hsa00240	1.74095893
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.70787534
21	Type I diabetes mellitus_Homo sapiens_hsa04940	1.69219580
22	RNA degradation_Homo sapiens_hsa03018	1.68482250
23	Nucleotide excision repair_Homo sapiens_hsa03420	1.58484396
24	Parkinsons disease_Homo sapiens_hsa05012	1.55528637
25	Base excision repair_Homo sapiens_hsa03410	1.53962973
26	Non-homologous end-joining_Homo sapiens_hsa03450	1.51093146
27	Ribosome_Homo sapiens_hsa03010	1.47268840
28	Basal transcription factors_Homo sapiens_hsa03022	1.44451982
29	Sulfur metabolism_Homo sapiens_hsa00920	1.40120057
30	Homologous recombination_Homo sapiens_hsa03440	1.38576348
31	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.36144847
32	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.32228201
33	RNA transport_Homo sapiens_hsa03013	1.30064407
34	Spliceosome_Homo sapiens_hsa03040	1.26628516
35	Purine metabolism_Homo sapiens_hsa00230	1.25342162
36	Propanoate metabolism_Homo sapiens_hsa00640	1.11266601
37	Nitrogen metabolism_Homo sapiens_hsa00910	1.10636951
38	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.07123342
39	Rheumatoid arthritis_Homo sapiens_hsa05323	1.06566069
40	Viral myocarditis_Homo sapiens_hsa05416	1.05535751
41	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.04866207
42	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.02840802
43	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.00076521
44	Huntingtons disease_Homo sapiens_hsa05016	0.96696950
45	Alzheimers disease_Homo sapiens_hsa05010	0.94709189
46	Pyruvate metabolism_Homo sapiens_hsa00620	0.94289419
47	Fatty acid elongation_Homo sapiens_hsa00062	0.91822383
48	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.90703113
49	Herpes simplex infection_Homo sapiens_hsa05168	0.90357321
50	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.89113631
51	Folate biosynthesis_Homo sapiens_hsa00790	0.88600611
52	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.86518836
53	Selenocompound metabolism_Homo sapiens_hsa00450	0.85084177
54	Fanconi anemia pathway_Homo sapiens_hsa03460	0.83094755
55	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.83036597
56	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.79937669
57	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.79822418
58	Caffeine metabolism_Homo sapiens_hsa00232	0.78171909
59	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.77923607
60	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.77609576
61	Legionellosis_Homo sapiens_hsa05134	0.77591269
62	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.75904148
63	Pentose phosphate pathway_Homo sapiens_hsa00030	0.75722963
64	Peroxisome_Homo sapiens_hsa04146	0.75219103
65	Measles_Homo sapiens_hsa05162	0.74594407
66	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.73452584
67	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.72947809
68	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.71359720
69	Carbon metabolism_Homo sapiens_hsa01200	0.69458504
70	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.68646128
71	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.68037470
72	Sulfur relay system_Homo sapiens_hsa04122	0.64898138
73	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.63733957
74	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.63022586
75	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.61880257
76	Leishmaniasis_Homo sapiens_hsa05140	0.60661693
77	Glutathione metabolism_Homo sapiens_hsa00480	0.60474882
78	p53 signaling pathway_Homo sapiens_hsa04115	0.59702626
79	Apoptosis_Homo sapiens_hsa04210	0.58627686
80	Shigellosis_Homo sapiens_hsa05131	0.56255834
81	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.53898446
82	Tryptophan metabolism_Homo sapiens_hsa00380	0.53214812
83	TNF signaling pathway_Homo sapiens_hsa04668	0.50616150
84	Regulation of autophagy_Homo sapiens_hsa04140	0.50539839
85	Metabolic pathways_Homo sapiens_hsa01100	0.49516105
86	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.45848763
87	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.45562182
88	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.43773073
89	Viral carcinogenesis_Homo sapiens_hsa05203	0.39931221
90	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.37101960
91	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.34158384
92	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.31676596
93	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.31640876
94	Toxoplasmosis_Homo sapiens_hsa05145	0.31261733
95	HTLV-I infection_Homo sapiens_hsa05166	0.30143049
96	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.29719531
97	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.28581086
98	Chemical carcinogenesis_Homo sapiens_hsa05204	0.28105120
99	Phototransduction_Homo sapiens_hsa04744	0.28042353
100	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.27839758

LDHAP3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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