LDHAP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.97891462
2cullin deneddylation (GO:0010388)4.86435190
3protein deneddylation (GO:0000338)4.73215909
4proteasome assembly (GO:0043248)4.63700920
5regulation of cellular amino acid metabolic process (GO:0006521)4.28904478
6DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.21532465
7negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.19020560
8signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.14085398
9signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.14085398
10signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.14085398
11intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.09175496
12signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.09175496
13positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.00724338
14rRNA modification (GO:0000154)3.94836152
15signal transduction involved in DNA integrity checkpoint (GO:0072401)3.92669747
16signal transduction involved in DNA damage checkpoint (GO:0072422)3.92669747
17signal transduction involved in cell cycle checkpoint (GO:0072395)3.92240706
18regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.81147259
19RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.80890234
20DNA double-strand break processing (GO:0000729)3.74008552
21negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.73010301
22negative regulation of ligase activity (GO:0051352)3.73010301
23pseudouridine synthesis (GO:0001522)3.54979624
24anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.53375600
25nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.51674414
26protein complex biogenesis (GO:0070271)3.48072455
27protein-cofactor linkage (GO:0018065)3.47217309
28positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.44946042
29DNA catabolic process, exonucleolytic (GO:0000738)3.43596331
30ribosome assembly (GO:0042255)3.38556526
31mitochondrial respiratory chain complex assembly (GO:0033108)3.38525440
32exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.35341039
33mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.35077591
34mitochondrial respiratory chain complex I assembly (GO:0032981)3.35077591
35NADH dehydrogenase complex assembly (GO:0010257)3.35077591
36water-soluble vitamin biosynthetic process (GO:0042364)3.34301589
37maturation of 5.8S rRNA (GO:0000460)3.33952567
38respiratory chain complex IV assembly (GO:0008535)3.31487650
39positive regulation of ligase activity (GO:0051351)3.30276269
40negative regulation of thymocyte apoptotic process (GO:0070244)3.29250275
41DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.26937440
42rRNA methylation (GO:0031167)3.25247020
43tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.24967168
44RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.24967168
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.18708303
46positive regulation of cell cycle arrest (GO:0071158)3.18569420
47transcription elongation from RNA polymerase III promoter (GO:0006385)3.13469769
48termination of RNA polymerase III transcription (GO:0006386)3.13469769
49adenosine metabolic process (GO:0046085)3.10721314
50preassembly of GPI anchor in ER membrane (GO:0016254)3.10587719
51metallo-sulfur cluster assembly (GO:0031163)3.03053618
52iron-sulfur cluster assembly (GO:0016226)3.03053618
53mannosylation (GO:0097502)3.02061621
54protein neddylation (GO:0045116)2.97433661
55regulation of cellular amine metabolic process (GO:0033238)2.96195606
56piRNA metabolic process (GO:0034587)2.96136071
57L-fucose catabolic process (GO:0042355)2.95899349
58fucose catabolic process (GO:0019317)2.95899349
59L-fucose metabolic process (GO:0042354)2.95899349
60somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.91471917
61isotype switching (GO:0045190)2.91471917
62somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.91471917
63positive regulation of defense response to virus by host (GO:0002230)2.91207667
64regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.89909690
65L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.89769956
66antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.88542398
67cytochrome complex assembly (GO:0017004)2.88025748
68tRNA processing (GO:0008033)2.85112330
69establishment of viral latency (GO:0019043)2.83929922
70postreplication repair (GO:0006301)2.83140584
71regulation of ubiquitin-protein transferase activity (GO:0051438)2.82765915
72protein K6-linked ubiquitination (GO:0085020)2.81963012
73aldehyde catabolic process (GO:0046185)2.78326749
74regulation of chronic inflammatory response (GO:0002676)2.78120507
75branched-chain amino acid catabolic process (GO:0009083)2.76682269
76tRNA metabolic process (GO:0006399)2.75688524
77regulation of ligase activity (GO:0051340)2.73195366
78energy coupled proton transport, down electrochemical gradient (GO:0015985)2.72804818
79ATP synthesis coupled proton transport (GO:0015986)2.72804818
80signal transduction in response to DNA damage (GO:0042770)2.71290040
81mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.68382048
82negative regulation of protein ubiquitination (GO:0031397)2.67141616
83mitochondrial RNA metabolic process (GO:0000959)2.67140878
84antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.66464868
85regulation of cell cycle arrest (GO:0071156)2.66069845
86organelle disassembly (GO:1903008)2.65887218
87DNA damage response, detection of DNA damage (GO:0042769)2.64529736
88C-terminal protein lipidation (GO:0006501)2.64520856
89cytidine deamination (GO:0009972)2.64033842
90cytidine metabolic process (GO:0046087)2.64033842
91cytidine catabolic process (GO:0006216)2.64033842
92nucleotide transmembrane transport (GO:1901679)2.63986310
93negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.63835868
94negative regulation of cell cycle G1/S phase transition (GO:1902807)2.63835868
95platelet dense granule organization (GO:0060155)2.63692446
96DNA replication-dependent nucleosome assembly (GO:0006335)2.63228242
97DNA replication-dependent nucleosome organization (GO:0034723)2.63228242
98response to pheromone (GO:0019236)2.62895624
99establishment of integrated proviral latency (GO:0075713)2.61382760
100ubiquinone biosynthetic process (GO:0006744)2.59140791

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.85542326
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.47830351
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.79302243
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.44562627
5ZNF274_21170338_ChIP-Seq_K562_Hela3.32556996
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.26117669
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.22647720
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.12326926
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.95939694
10VDR_23849224_ChIP-Seq_CD4+_Human2.92529274
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.76425063
12VDR_22108803_ChIP-Seq_LS180_Human2.65160922
13ELK1_19687146_ChIP-ChIP_HELA_Human2.53837936
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.44608144
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.36058282
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.34443556
17FOXP3_21729870_ChIP-Seq_TREG_Human2.33408993
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.26330408
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.20789143
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.16268625
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.10187782
22PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97247407
23IGF1R_20145208_ChIP-Seq_DFB_Human1.96514223
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.90344941
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.89867468
26FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.88054407
27DCP1A_22483619_ChIP-Seq_HELA_Human1.83666861
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.82987002
29PADI4_21655091_ChIP-ChIP_MCF-7_Human1.82575727
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.78158071
31MYC_18940864_ChIP-ChIP_HL60_Human1.78054571
32FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.70877962
33IRF1_19129219_ChIP-ChIP_H3396_Human1.66094494
34HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62045855
35EWS_26573619_Chip-Seq_HEK293_Human1.61589846
36GABP_19822575_ChIP-Seq_HepG2_Human1.60617484
37MYC_18358816_ChIP-ChIP_MESCs_Mouse1.51486099
38E2F7_22180533_ChIP-Seq_HELA_Human1.49905862
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49256074
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48630848
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.46221118
42CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.43879594
43FUS_26573619_Chip-Seq_HEK293_Human1.42831294
44MYC_19030024_ChIP-ChIP_MESCs_Mouse1.40563941
45MYC_18555785_ChIP-Seq_MESCs_Mouse1.39623539
46FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.38602497
47TP53_22573176_ChIP-Seq_HFKS_Human1.32834282
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.32213401
49E2F1_18555785_ChIP-Seq_MESCs_Mouse1.31418865
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26040310
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25309439
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22226970
53IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.21296746
54NELFA_20434984_ChIP-Seq_ESCs_Mouse1.19696798
55IRF8_22096565_ChIP-ChIP_GC-B_Human1.18617262
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.18311683
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18311683
58ELK1_22589737_ChIP-Seq_MCF10A_Human1.17977422
59P300_19829295_ChIP-Seq_ESCs_Human1.16594019
60TTF2_22483619_ChIP-Seq_HELA_Human1.15262366
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15224547
62GATA3_26560356_Chip-Seq_TH2_Human1.14354858
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13301177
64EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.12806394
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12469350
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12304327
67TAF15_26573619_Chip-Seq_HEK293_Human1.10569636
68SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10540157
69CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.10096566
70PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.09195979
71AR_20517297_ChIP-Seq_VCAP_Human1.08900859
72GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.07950542
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06385203
74HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06228573
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05245879
76NANOG_19829295_ChIP-Seq_ESCs_Human1.03904037
77SOX2_19829295_ChIP-Seq_ESCs_Human1.03904037
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.03624716
79CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02481869
80HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.01159218
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99163695
82CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99143371
83BP1_19119308_ChIP-ChIP_Hs578T_Human0.99065602
84MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.98532931
85CIITA_25753668_ChIP-Seq_RAJI_Human0.97293457
86EZH2_27294783_Chip-Seq_NPCs_Mouse0.96789741
87SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.93069502
88IRF8_21731497_ChIP-ChIP_J774_Mouse0.92562967
89EGR1_23403033_ChIP-Seq_LIVER_Mouse0.91832901
90HOXB7_26014856_ChIP-Seq_BT474_Human0.91434835
91GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90272706
92ER_23166858_ChIP-Seq_MCF-7_Human0.89991954
93MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.88621913
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.87982148
95CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87662978
96PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.87551331
97CBP_20019798_ChIP-Seq_JUKART_Human0.87285849
98IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87285849
99NCOR_22424771_ChIP-Seq_293T_Human0.87271033
100FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86994130

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair3.12101384
2MP0003950_abnormal_plasma_membrane2.95469609
3MP0002102_abnormal_ear_morphology2.64731302
4MP0004147_increased_porphyrin_level2.60156966
5MP0010094_abnormal_chromosome_stability2.59840593
6MP0008877_abnormal_DNA_methylation2.55806704
7MP0006072_abnormal_retinal_apoptosis2.45981810
8MP0003786_premature_aging2.44454656
9MP0003718_maternal_effect2.37672737
10MP0005671_abnormal_response_to2.33510149
11MP0008872_abnormal_physiological_respon2.30724361
12MP0001835_abnormal_antigen_presentation2.28467621
13MP0003806_abnormal_nucleotide_metabolis2.27207857
14MP0008875_abnormal_xenobiotic_pharmacok2.23302988
15MP0003693_abnormal_embryo_hatching2.22399439
16MP0001968_abnormal_touch/_nociception2.19387506
17MP0000372_irregular_coat_pigmentation2.10341132
18MP0005084_abnormal_gallbladder_morpholo2.02961780
19MP0002138_abnormal_hepatobiliary_system1.99389277
20MP0002876_abnormal_thyroid_physiology1.96989519
21MP0001984_abnormal_olfaction1.94119547
22MP0009697_abnormal_copulation1.92767371
23MP0000685_abnormal_immune_system1.85948070
24MP0002006_tumorigenesis1.84890913
25MP0002148_abnormal_hypersensitivity_rea1.68820519
26MP0005551_abnormal_eye_electrophysiolog1.66254944
27MP0009785_altered_susceptibility_to1.65015693
28MP0006036_abnormal_mitochondrial_physio1.64822216
29MP0002736_abnormal_nociception_after1.63607205
30MP0008007_abnormal_cellular_replicative1.62779746
31MP0002166_altered_tumor_susceptibility1.62545948
32MP0003186_abnormal_redox_activity1.61147151
33MP0006035_abnormal_mitochondrial_morpho1.60304167
34MP0003195_calcinosis1.55724039
35MP0004957_abnormal_blastocyst_morpholog1.55006197
36MP0005075_abnormal_melanosome_morpholog1.54489992
37MP0001501_abnormal_sleep_pattern1.49743909
38MP0001873_stomach_inflammation1.48566198
39MP0005645_abnormal_hypothalamus_physiol1.43784481
40MP0001790_abnormal_immune_system1.40159492
41MP0005387_immune_system_phenotype1.40159492
42MP0009764_decreased_sensitivity_to1.33519742
43MP0009333_abnormal_splenocyte_physiolog1.25811894
44MP0004145_abnormal_muscle_electrophysio1.25550323
45MP0005253_abnormal_eye_physiology1.21641470
46MP0001800_abnormal_humoral_immune1.20401699
47MP0000427_abnormal_hair_cycle1.19133453
48MP0005360_urolithiasis1.18213167
49MP0004782_abnormal_surfactant_physiolog1.14843512
50MP0008775_abnormal_heart_ventricle1.14767631
51MP0005000_abnormal_immune_tolerance1.13543844
52MP0001764_abnormal_homeostasis1.11398361
53MP0002837_dystrophic_cardiac_calcinosis1.08995216
54MP0006292_abnormal_olfactory_placode1.08860600
55MP0002751_abnormal_autonomic_nervous1.08822600
56MP0004215_abnormal_myocardial_fiber1.07813687
57MP0005646_abnormal_pituitary_gland1.02125263
58MP0001905_abnormal_dopamine_level1.02036037
59MP0000647_abnormal_sebaceous_gland1.01651623
60MP0005410_abnormal_fertilization1.01155897
61MP0001529_abnormal_vocalization1.00216547
62MP0001986_abnormal_taste_sensitivity0.99559425
63MP0005389_reproductive_system_phenotype0.99155780
64MP0005367_renal/urinary_system_phenotyp0.97281222
65MP0000516_abnormal_urinary_system0.97281222
66MP0003567_abnormal_fetal_cardiomyocyte0.96092589
67MP0003763_abnormal_thymus_physiology0.94916879
68MP0003111_abnormal_nucleus_morphology0.94673649
69MP0000749_muscle_degeneration0.94541936
70MP0002163_abnormal_gland_morphology0.94537211
71MP0004043_abnormal_pH_regulation0.94257311
72MP0005395_other_phenotype0.93132129
73MP0000689_abnormal_spleen_morphology0.92801292
74MP0002452_abnormal_antigen_presenting0.91966421
75MP0002723_abnormal_immune_serum0.91476582
76MP0008789_abnormal_olfactory_epithelium0.91055160
77MP0001919_abnormal_reproductive_system0.90995989
78MP0002019_abnormal_tumor_incidence0.90466327
79MP0003436_decreased_susceptibility_to0.90278994
80MP0000358_abnormal_cell_content/0.85813965
81MP0001293_anophthalmia0.84813351
82MP0001929_abnormal_gametogenesis0.84703884
83MP0001819_abnormal_immune_cell0.84391435
84MP0004142_abnormal_muscle_tone0.84293114
85MP0002420_abnormal_adaptive_immunity0.83488825
86MP0000013_abnormal_adipose_tissue0.83461198
87MP0008873_increased_physiological_sensi0.81787729
88MP0002722_abnormal_immune_system0.79850111
89MP0003077_abnormal_cell_cycle0.79689838
90MP0008932_abnormal_embryonic_tissue0.76184425
91MP0000703_abnormal_thymus_morphology0.72984766
92MP0001119_abnormal_female_reproductive0.72324027
93MP0001243_abnormal_dermal_layer0.71497747
94MP0009046_muscle_twitch0.71480310
95MP0002210_abnormal_sex_determination0.71470599
96MP0000653_abnormal_sex_gland0.69309467
97MP0002398_abnormal_bone_marrow0.68999167
98MP0002160_abnormal_reproductive_system0.68762654
99MP0005379_endocrine/exocrine_gland_phen0.68577235
100MP0008995_early_reproductive_senescence0.67913048

Predicted human phenotypes

RankGene SetZ-score
1Increased CSF lactate (HP:0002490)3.77849820
2Acute necrotizing encephalopathy (HP:0006965)3.68531693
3Mitochondrial inheritance (HP:0001427)3.61251746
4Increased serum pyruvate (HP:0003542)3.52013095
5IgG deficiency (HP:0004315)3.50849884
6Acute encephalopathy (HP:0006846)3.37979802
7Hepatocellular necrosis (HP:0001404)3.37341358
8Abnormality of glycolysis (HP:0004366)3.33339619
9Increased serum lactate (HP:0002151)3.29593557
10Abnormal mitochondria in muscle tissue (HP:0008316)3.27811883
11Progressive macrocephaly (HP:0004481)3.20611155
12Hypoproteinemia (HP:0003075)3.18407409
13Hepatic necrosis (HP:0002605)3.01199218
14Increased hepatocellular lipid droplets (HP:0006565)3.00971468
15Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.98329302
16Abnormality of alanine metabolism (HP:0010916)2.98329302
17Hyperalaninemia (HP:0003348)2.98329302
18Abnormality of B cell number (HP:0010975)2.95787411
19Molar tooth sign on MRI (HP:0002419)2.88949490
20Abnormality of midbrain morphology (HP:0002418)2.88949490
21Abnormality of the renal cortex (HP:0011035)2.88023233
22Pancreatic cysts (HP:0001737)2.83071471
23Lipid accumulation in hepatocytes (HP:0006561)2.81809898
24Renal cortical cysts (HP:0000803)2.81094677
25Stomatitis (HP:0010280)2.78895255
26Lactic acidosis (HP:0003128)2.64275926
27B lymphocytopenia (HP:0010976)2.60150847
28Cerebral edema (HP:0002181)2.53720944
29Nephronophthisis (HP:0000090)2.45136965
30Abolished electroretinogram (ERG) (HP:0000550)2.43041364
31Aplasia/hypoplasia of the uterus (HP:0008684)2.42597657
32Methylmalonic acidemia (HP:0002912)2.40017834
33Type I transferrin isoform profile (HP:0003642)2.38697969
34Methylmalonic aciduria (HP:0012120)2.37201818
35Severe combined immunodeficiency (HP:0004430)2.36859548
36Abnormality of T cell physiology (HP:0011840)2.36254184
37Renal Fanconi syndrome (HP:0001994)2.35435785
38Volvulus (HP:0002580)2.34827829
39Elevated erythrocyte sedimentation rate (HP:0003565)2.34064331
40Congenital stationary night blindness (HP:0007642)2.32843658
41Stomach cancer (HP:0012126)2.31450575
42Delayed CNS myelination (HP:0002188)2.31199646
43True hermaphroditism (HP:0010459)2.30626453
44Abnormal protein glycosylation (HP:0012346)2.29413963
45Abnormal glycosylation (HP:0012345)2.29413963
46Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.29413963
47Abnormal protein N-linked glycosylation (HP:0012347)2.29413963
48Optic disc pallor (HP:0000543)2.28728306
49Abnormality of the renal medulla (HP:0100957)2.28536419
50Exercise intolerance (HP:0003546)2.26926966
51Progressive inability to walk (HP:0002505)2.25886370
523-Methylglutaconic aciduria (HP:0003535)2.23125882
53Type 2 muscle fiber atrophy (HP:0003554)2.18294091
54Medial flaring of the eyebrow (HP:0010747)2.16717110
55Pancreatic fibrosis (HP:0100732)2.16390412
56Respiratory failure (HP:0002878)2.15185137
57Progressive microcephaly (HP:0000253)2.11072049
58Abnormality of the anterior horn cell (HP:0006802)2.10957867
59Degeneration of anterior horn cells (HP:0002398)2.10957867
60Hypoplasia of the uterus (HP:0000013)2.07841179
61Lethargy (HP:0001254)2.03746451
62Tongue fasciculations (HP:0001308)2.02053468
63Thyroiditis (HP:0100646)2.01871526
64Colon cancer (HP:0003003)2.00343258
65Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.99288020
66Increased intramyocellular lipid droplets (HP:0012240)1.98806433
67Type II lissencephaly (HP:0007260)1.97350971
68Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.96555936
69Abnormality of the ileum (HP:0001549)1.95700082
70Inability to walk (HP:0002540)1.95591424
71Abnormality of T cells (HP:0002843)1.93866153
72Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.91942402
73Decreased activity of mitochondrial respiratory chain (HP:0008972)1.91942402
74IgM deficiency (HP:0002850)1.91660749
75Constricted visual fields (HP:0001133)1.91398159
76Decreased electroretinogram (ERG) amplitude (HP:0000654)1.91331518
77Tubular atrophy (HP:0000092)1.89966692
78Panhypogammaglobulinemia (HP:0003139)1.89485883
79Entropion (HP:0000621)1.89412175
80Abnormality of the pons (HP:0007361)1.89239022
81Attenuation of retinal blood vessels (HP:0007843)1.89179242
82Exertional dyspnea (HP:0002875)1.88852049
83Generalized aminoaciduria (HP:0002909)1.88035856
84Opisthotonus (HP:0002179)1.87914375
85Pendular nystagmus (HP:0012043)1.87345475
86Abnormal rod and cone electroretinograms (HP:0008323)1.83903738
87Pancytopenia (HP:0001876)1.80966025
88Eosinophilia (HP:0001880)1.80765818
89Increased IgM level (HP:0003496)1.80361126
90Atrophy/Degeneration involving motor neurons (HP:0007373)1.80207211
91Combined immunodeficiency (HP:0005387)1.78854063
92Adactyly (HP:0009776)1.77878715
93Congenital, generalized hypertrichosis (HP:0004540)1.77413657
94Meckel diverticulum (HP:0002245)1.77086618
95Abnormality of aspartate family amino acid metabolism (HP:0010899)1.76560791
96Large for gestational age (HP:0001520)1.75762440
97Abnormality of serum amino acid levels (HP:0003112)1.75596672
98Severe muscular hypotonia (HP:0006829)1.74718628
99Autoimmune hemolytic anemia (HP:0001890)1.72834635
100Glycosuria (HP:0003076)1.72779849

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.72663006
2ZAK2.77477100
3EIF2AK32.70476352
4MAP4K22.68486531
5FRK2.59364867
6TAOK32.43599083
7BUB12.41116365
8TSSK62.40691991
9NUAK12.36210111
10MST42.35358774
11VRK12.25181970
12TXK2.16812500
13ADRBK22.16159643
14BMPR1B2.02873820
15EIF2AK11.98642221
16TLK11.93787698
17SRPK11.84549789
18TRIM281.82025733
19NEK11.80670864
20PLK31.79935905
21PLK21.72166298
22BCKDK1.59419280
23TESK21.54707317
24PLK41.49869485
25BCR1.49067613
26PBK1.41661855
27MAP3K121.31681750
28GRK11.30981586
29EIF2AK21.29077441
30WNK31.27864395
31DAPK11.24630946
32WNK41.24104020
33CSNK1G31.21651098
34PINK11.15647275
35PDK21.13632978
36SCYL21.13100891
37KDR1.09095629
38CDK81.08500265
39NME11.08319917
40CSNK1A1L1.07813206
41CCNB11.06663527
42CSNK1G11.03953186
43FLT31.01451310
44TEC0.94788470
45TNIK0.94138753
46PHKG10.93447422
47PHKG20.93447422
48STK390.93128871
49TGFBR10.92547216
50LIMK10.90470508
51STK160.89676991
52CSNK1G20.89147959
53KIT0.87688225
54OXSR10.87254766
55TESK10.86165578
56IKBKB0.84986888
57MKNK20.84879905
58MAPKAPK30.83652957
59GRK50.79858173
60MUSK0.76672957
61MKNK10.76368526
62TAF10.75188546
63ERBB30.74735401
64MAPKAPK50.67292718
65MAP2K70.66973315
66MAPK130.66819085
67PRKCE0.63822027
68ATR0.63317148
69PLK10.63198726
70ADRBK10.63046005
71PTK2B0.62106758
72CAMKK20.61204290
73PRKCI0.60529485
74TTK0.60130796
75ITK0.59825534
76INSRR0.58309851
77IKBKE0.57567565
78ACVR1B0.56964417
79GRK70.52736568
80RPS6KA50.50490360
81MAP3K40.49602925
82MAP3K140.49141382
83PIK3CG0.48816406
84PIM20.47382818
85MAP2K60.46477046
86AURKB0.45676680
87GRK60.44846150
88BRSK20.42374748
89AURKA0.41267581
90CDC70.38665916
91STK100.36213031
92CSNK1A10.35627596
93ATM0.35574504
94CLK10.35197082
95ABL10.34567368
96SYK0.34562904
97MAP4K10.33650598
98MYLK0.32637074
99IGF1R0.31667826
100SIK30.31363657

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.48471758
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.82842389
3Protein export_Homo sapiens_hsa030602.74433202
4RNA polymerase_Homo sapiens_hsa030202.49725480
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.43617449
6Oxidative phosphorylation_Homo sapiens_hsa001902.27067015
7Non-homologous end-joining_Homo sapiens_hsa034502.25440778
8Mismatch repair_Homo sapiens_hsa034302.04155480
9Homologous recombination_Homo sapiens_hsa034402.00781415
10Parkinsons disease_Homo sapiens_hsa050122.00206904
11DNA replication_Homo sapiens_hsa030301.93326717
12Propanoate metabolism_Homo sapiens_hsa006401.91299903
13RNA degradation_Homo sapiens_hsa030181.88364050
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.86944222
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.85727405
16Base excision repair_Homo sapiens_hsa034101.84566833
17Primary immunodeficiency_Homo sapiens_hsa053401.82660598
18Pyrimidine metabolism_Homo sapiens_hsa002401.61643674
19One carbon pool by folate_Homo sapiens_hsa006701.60917055
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.59313963
21Basal transcription factors_Homo sapiens_hsa030221.59012280
22Asthma_Homo sapiens_hsa053101.55806902
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.50972076
24Allograft rejection_Homo sapiens_hsa053301.50920681
25Phototransduction_Homo sapiens_hsa047441.47017152
26Fanconi anemia pathway_Homo sapiens_hsa034601.46385398
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.45587816
28Nucleotide excision repair_Homo sapiens_hsa034201.42881026
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42412561
30RNA transport_Homo sapiens_hsa030131.38766878
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.35513735
32Purine metabolism_Homo sapiens_hsa002301.31042623
33Autoimmune thyroid disease_Homo sapiens_hsa053201.30839734
34Graft-versus-host disease_Homo sapiens_hsa053321.30402409
35Spliceosome_Homo sapiens_hsa030401.26400235
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25822097
37Nitrogen metabolism_Homo sapiens_hsa009101.23789885
38Huntingtons disease_Homo sapiens_hsa050161.23595767
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.19825776
40Antigen processing and presentation_Homo sapiens_hsa046121.16871105
41Sulfur metabolism_Homo sapiens_hsa009201.14156974
42Alzheimers disease_Homo sapiens_hsa050101.13401474
43Fatty acid elongation_Homo sapiens_hsa000621.11361826
44Type I diabetes mellitus_Homo sapiens_hsa049401.11086153
45Selenocompound metabolism_Homo sapiens_hsa004501.09200710
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03130948
47Peroxisome_Homo sapiens_hsa041461.01429341
48Pyruvate metabolism_Homo sapiens_hsa006200.99620852
49Caffeine metabolism_Homo sapiens_hsa002320.98811797
50Linoleic acid metabolism_Homo sapiens_hsa005910.96508950
51Butanoate metabolism_Homo sapiens_hsa006500.96488463
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.92935574
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.91403397
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86071976
55Steroid biosynthesis_Homo sapiens_hsa001000.80376803
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76076157
57Glutathione metabolism_Homo sapiens_hsa004800.75783724
58Ether lipid metabolism_Homo sapiens_hsa005650.74880911
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74566876
60Folate biosynthesis_Homo sapiens_hsa007900.73345286
61Carbon metabolism_Homo sapiens_hsa012000.72927650
62Sulfur relay system_Homo sapiens_hsa041220.72327267
63Biosynthesis of amino acids_Homo sapiens_hsa012300.72241525
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.70252691
65Metabolic pathways_Homo sapiens_hsa011000.70155206
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67322893
67Arachidonic acid metabolism_Homo sapiens_hsa005900.66807192
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66134835
69Regulation of autophagy_Homo sapiens_hsa041400.65696555
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65672381
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62740982
72Tryptophan metabolism_Homo sapiens_hsa003800.61155284
73Rheumatoid arthritis_Homo sapiens_hsa053230.59844928
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58243844
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58036317
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57060532
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56404873
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54528203
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51745372
80Systemic lupus erythematosus_Homo sapiens_hsa053220.51549114
81Pentose phosphate pathway_Homo sapiens_hsa000300.51041854
82Hematopoietic cell lineage_Homo sapiens_hsa046400.50206813
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50170125
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.48908205
85Chemical carcinogenesis_Homo sapiens_hsa052040.47562024
86N-Glycan biosynthesis_Homo sapiens_hsa005100.46898271
87Collecting duct acid secretion_Homo sapiens_hsa049660.46710122
88Epstein-Barr virus infection_Homo sapiens_hsa051690.45436523
89p53 signaling pathway_Homo sapiens_hsa041150.43509162
90Fat digestion and absorption_Homo sapiens_hsa049750.43339608
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42077857
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40575412
93Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39731400
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.37325120
95Viral myocarditis_Homo sapiens_hsa054160.37157415
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35816077
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.34737228
98NF-kappa B signaling pathway_Homo sapiens_hsa040640.33044950
99Ribosome_Homo sapiens_hsa030100.33002373
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32705064

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