

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 4.97891462 |
| 2 | cullin deneddylation (GO:0010388) | 4.86435190 |
| 3 | protein deneddylation (GO:0000338) | 4.73215909 |
| 4 | proteasome assembly (GO:0043248) | 4.63700920 |
| 5 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.28904478 |
| 6 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 4.21532465 |
| 7 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.19020560 |
| 8 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 4.14085398 |
| 9 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 4.14085398 |
| 10 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 4.14085398 |
| 11 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 4.09175496 |
| 12 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 4.09175496 |
| 13 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.00724338 |
| 14 | rRNA modification (GO:0000154) | 3.94836152 |
| 15 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.92669747 |
| 16 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.92669747 |
| 17 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.92240706 |
| 18 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.81147259 |
| 19 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.80890234 |
| 20 | DNA double-strand break processing (GO:0000729) | 3.74008552 |
| 21 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.73010301 |
| 22 | negative regulation of ligase activity (GO:0051352) | 3.73010301 |
| 23 | pseudouridine synthesis (GO:0001522) | 3.54979624 |
| 24 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.53375600 |
| 25 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.51674414 |
| 26 | protein complex biogenesis (GO:0070271) | 3.48072455 |
| 27 | protein-cofactor linkage (GO:0018065) | 3.47217309 |
| 28 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.44946042 |
| 29 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.43596331 |
| 30 | ribosome assembly (GO:0042255) | 3.38556526 |
| 31 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.38525440 |
| 32 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.35341039 |
| 33 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.35077591 |
| 34 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.35077591 |
| 35 | NADH dehydrogenase complex assembly (GO:0010257) | 3.35077591 |
| 36 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.34301589 |
| 37 | maturation of 5.8S rRNA (GO:0000460) | 3.33952567 |
| 38 | respiratory chain complex IV assembly (GO:0008535) | 3.31487650 |
| 39 | positive regulation of ligase activity (GO:0051351) | 3.30276269 |
| 40 | negative regulation of thymocyte apoptotic process (GO:0070244) | 3.29250275 |
| 41 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 3.26937440 |
| 42 | rRNA methylation (GO:0031167) | 3.25247020 |
| 43 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.24967168 |
| 44 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.24967168 |
| 45 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.18708303 |
| 46 | positive regulation of cell cycle arrest (GO:0071158) | 3.18569420 |
| 47 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.13469769 |
| 48 | termination of RNA polymerase III transcription (GO:0006386) | 3.13469769 |
| 49 | adenosine metabolic process (GO:0046085) | 3.10721314 |
| 50 | preassembly of GPI anchor in ER membrane (GO:0016254) | 3.10587719 |
| 51 | metallo-sulfur cluster assembly (GO:0031163) | 3.03053618 |
| 52 | iron-sulfur cluster assembly (GO:0016226) | 3.03053618 |
| 53 | mannosylation (GO:0097502) | 3.02061621 |
| 54 | protein neddylation (GO:0045116) | 2.97433661 |
| 55 | regulation of cellular amine metabolic process (GO:0033238) | 2.96195606 |
| 56 | piRNA metabolic process (GO:0034587) | 2.96136071 |
| 57 | L-fucose catabolic process (GO:0042355) | 2.95899349 |
| 58 | fucose catabolic process (GO:0019317) | 2.95899349 |
| 59 | L-fucose metabolic process (GO:0042354) | 2.95899349 |
| 60 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 2.91471917 |
| 61 | isotype switching (GO:0045190) | 2.91471917 |
| 62 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 2.91471917 |
| 63 | positive regulation of defense response to virus by host (GO:0002230) | 2.91207667 |
| 64 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 2.89909690 |
| 65 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.89769956 |
| 66 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 2.88542398 |
| 67 | cytochrome complex assembly (GO:0017004) | 2.88025748 |
| 68 | tRNA processing (GO:0008033) | 2.85112330 |
| 69 | establishment of viral latency (GO:0019043) | 2.83929922 |
| 70 | postreplication repair (GO:0006301) | 2.83140584 |
| 71 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.82765915 |
| 72 | protein K6-linked ubiquitination (GO:0085020) | 2.81963012 |
| 73 | aldehyde catabolic process (GO:0046185) | 2.78326749 |
| 74 | regulation of chronic inflammatory response (GO:0002676) | 2.78120507 |
| 75 | branched-chain amino acid catabolic process (GO:0009083) | 2.76682269 |
| 76 | tRNA metabolic process (GO:0006399) | 2.75688524 |
| 77 | regulation of ligase activity (GO:0051340) | 2.73195366 |
| 78 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 2.72804818 |
| 79 | ATP synthesis coupled proton transport (GO:0015986) | 2.72804818 |
| 80 | signal transduction in response to DNA damage (GO:0042770) | 2.71290040 |
| 81 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 2.68382048 |
| 82 | negative regulation of protein ubiquitination (GO:0031397) | 2.67141616 |
| 83 | mitochondrial RNA metabolic process (GO:0000959) | 2.67140878 |
| 84 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 2.66464868 |
| 85 | regulation of cell cycle arrest (GO:0071156) | 2.66069845 |
| 86 | organelle disassembly (GO:1903008) | 2.65887218 |
| 87 | DNA damage response, detection of DNA damage (GO:0042769) | 2.64529736 |
| 88 | C-terminal protein lipidation (GO:0006501) | 2.64520856 |
| 89 | cytidine deamination (GO:0009972) | 2.64033842 |
| 90 | cytidine metabolic process (GO:0046087) | 2.64033842 |
| 91 | cytidine catabolic process (GO:0006216) | 2.64033842 |
| 92 | nucleotide transmembrane transport (GO:1901679) | 2.63986310 |
| 93 | negative regulation of G1/S transition of mitotic cell cycle (GO:2000134) | 2.63835868 |
| 94 | negative regulation of cell cycle G1/S phase transition (GO:1902807) | 2.63835868 |
| 95 | platelet dense granule organization (GO:0060155) | 2.63692446 |
| 96 | DNA replication-dependent nucleosome assembly (GO:0006335) | 2.63228242 |
| 97 | DNA replication-dependent nucleosome organization (GO:0034723) | 2.63228242 |
| 98 | response to pheromone (GO:0019236) | 2.62895624 |
| 99 | establishment of integrated proviral latency (GO:0075713) | 2.61382760 |
| 100 | ubiquinone biosynthetic process (GO:0006744) | 2.59140791 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.85542326 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.47830351 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.79302243 |
| 4 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.44562627 |
| 5 | ZNF274_21170338_ChIP-Seq_K562_Hela | 3.32556996 |
| 6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.26117669 |
| 7 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.22647720 |
| 8 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.12326926 |
| 9 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.95939694 |
| 10 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.92529274 |
| 11 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.76425063 |
| 12 | VDR_22108803_ChIP-Seq_LS180_Human | 2.65160922 |
| 13 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.53837936 |
| 14 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.44608144 |
| 15 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.36058282 |
| 16 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.34443556 |
| 17 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.33408993 |
| 18 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.26330408 |
| 19 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.20789143 |
| 20 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.16268625 |
| 21 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.10187782 |
| 22 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.97247407 |
| 23 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.96514223 |
| 24 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.90344941 |
| 25 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.89867468 |
| 26 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.88054407 |
| 27 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.83666861 |
| 28 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.82987002 |
| 29 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.82575727 |
| 30 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.78158071 |
| 31 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.78054571 |
| 32 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.70877962 |
| 33 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.66094494 |
| 34 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.62045855 |
| 35 | EWS_26573619_Chip-Seq_HEK293_Human | 1.61589846 |
| 36 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.60617484 |
| 37 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.51486099 |
| 38 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.49905862 |
| 39 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.49256074 |
| 40 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.48630848 |
| 41 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.46221118 |
| 42 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.43879594 |
| 43 | FUS_26573619_Chip-Seq_HEK293_Human | 1.42831294 |
| 44 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.40563941 |
| 45 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.39623539 |
| 46 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.38602497 |
| 47 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.32834282 |
| 48 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.32213401 |
| 49 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.31418865 |
| 50 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.26040310 |
| 51 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.25309439 |
| 52 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.22226970 |
| 53 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.21296746 |
| 54 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.19696798 |
| 55 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.18617262 |
| 56 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.18311683 |
| 57 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.18311683 |
| 58 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.17977422 |
| 59 | P300_19829295_ChIP-Seq_ESCs_Human | 1.16594019 |
| 60 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.15262366 |
| 61 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.15224547 |
| 62 | GATA3_26560356_Chip-Seq_TH2_Human | 1.14354858 |
| 63 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.13301177 |
| 64 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.12806394 |
| 65 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.12469350 |
| 66 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.12304327 |
| 67 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.10569636 |
| 68 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.10540157 |
| 69 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.10096566 |
| 70 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.09195979 |
| 71 | AR_20517297_ChIP-Seq_VCAP_Human | 1.08900859 |
| 72 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.07950542 |
| 73 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.06385203 |
| 74 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.06228573 |
| 75 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.05245879 |
| 76 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.03904037 |
| 77 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.03904037 |
| 78 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.03624716 |
| 79 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.02481869 |
| 80 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.01159218 |
| 81 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 0.99163695 |
| 82 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.99143371 |
| 83 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 0.99065602 |
| 84 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 0.98532931 |
| 85 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.97293457 |
| 86 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.96789741 |
| 87 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.93069502 |
| 88 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 0.92562967 |
| 89 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.91832901 |
| 90 | HOXB7_26014856_ChIP-Seq_BT474_Human | 0.91434835 |
| 91 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.90272706 |
| 92 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.89991954 |
| 93 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.88621913 |
| 94 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.87982148 |
| 95 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.87662978 |
| 96 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.87551331 |
| 97 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.87285849 |
| 98 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.87285849 |
| 99 | NCOR_22424771_ChIP-Seq_293T_Human | 0.87271033 |
| 100 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.86994130 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008058_abnormal_DNA_repair | 3.12101384 |
| 2 | MP0003950_abnormal_plasma_membrane | 2.95469609 |
| 3 | MP0002102_abnormal_ear_morphology | 2.64731302 |
| 4 | MP0004147_increased_porphyrin_level | 2.60156966 |
| 5 | MP0010094_abnormal_chromosome_stability | 2.59840593 |
| 6 | MP0008877_abnormal_DNA_methylation | 2.55806704 |
| 7 | MP0006072_abnormal_retinal_apoptosis | 2.45981810 |
| 8 | MP0003786_premature_aging | 2.44454656 |
| 9 | MP0003718_maternal_effect | 2.37672737 |
| 10 | MP0005671_abnormal_response_to | 2.33510149 |
| 11 | MP0008872_abnormal_physiological_respon | 2.30724361 |
| 12 | MP0001835_abnormal_antigen_presentation | 2.28467621 |
| 13 | MP0003806_abnormal_nucleotide_metabolis | 2.27207857 |
| 14 | MP0008875_abnormal_xenobiotic_pharmacok | 2.23302988 |
| 15 | MP0003693_abnormal_embryo_hatching | 2.22399439 |
| 16 | MP0001968_abnormal_touch/_nociception | 2.19387506 |
| 17 | MP0000372_irregular_coat_pigmentation | 2.10341132 |
| 18 | MP0005084_abnormal_gallbladder_morpholo | 2.02961780 |
| 19 | MP0002138_abnormal_hepatobiliary_system | 1.99389277 |
| 20 | MP0002876_abnormal_thyroid_physiology | 1.96989519 |
| 21 | MP0001984_abnormal_olfaction | 1.94119547 |
| 22 | MP0009697_abnormal_copulation | 1.92767371 |
| 23 | MP0000685_abnormal_immune_system | 1.85948070 |
| 24 | MP0002006_tumorigenesis | 1.84890913 |
| 25 | MP0002148_abnormal_hypersensitivity_rea | 1.68820519 |
| 26 | MP0005551_abnormal_eye_electrophysiolog | 1.66254944 |
| 27 | MP0009785_altered_susceptibility_to | 1.65015693 |
| 28 | MP0006036_abnormal_mitochondrial_physio | 1.64822216 |
| 29 | MP0002736_abnormal_nociception_after | 1.63607205 |
| 30 | MP0008007_abnormal_cellular_replicative | 1.62779746 |
| 31 | MP0002166_altered_tumor_susceptibility | 1.62545948 |
| 32 | MP0003186_abnormal_redox_activity | 1.61147151 |
| 33 | MP0006035_abnormal_mitochondrial_morpho | 1.60304167 |
| 34 | MP0003195_calcinosis | 1.55724039 |
| 35 | MP0004957_abnormal_blastocyst_morpholog | 1.55006197 |
| 36 | MP0005075_abnormal_melanosome_morpholog | 1.54489992 |
| 37 | MP0001501_abnormal_sleep_pattern | 1.49743909 |
| 38 | MP0001873_stomach_inflammation | 1.48566198 |
| 39 | MP0005645_abnormal_hypothalamus_physiol | 1.43784481 |
| 40 | MP0001790_abnormal_immune_system | 1.40159492 |
| 41 | MP0005387_immune_system_phenotype | 1.40159492 |
| 42 | MP0009764_decreased_sensitivity_to | 1.33519742 |
| 43 | MP0009333_abnormal_splenocyte_physiolog | 1.25811894 |
| 44 | MP0004145_abnormal_muscle_electrophysio | 1.25550323 |
| 45 | MP0005253_abnormal_eye_physiology | 1.21641470 |
| 46 | MP0001800_abnormal_humoral_immune | 1.20401699 |
| 47 | MP0000427_abnormal_hair_cycle | 1.19133453 |
| 48 | MP0005360_urolithiasis | 1.18213167 |
| 49 | MP0004782_abnormal_surfactant_physiolog | 1.14843512 |
| 50 | MP0008775_abnormal_heart_ventricle | 1.14767631 |
| 51 | MP0005000_abnormal_immune_tolerance | 1.13543844 |
| 52 | MP0001764_abnormal_homeostasis | 1.11398361 |
| 53 | MP0002837_dystrophic_cardiac_calcinosis | 1.08995216 |
| 54 | MP0006292_abnormal_olfactory_placode | 1.08860600 |
| 55 | MP0002751_abnormal_autonomic_nervous | 1.08822600 |
| 56 | MP0004215_abnormal_myocardial_fiber | 1.07813687 |
| 57 | MP0005646_abnormal_pituitary_gland | 1.02125263 |
| 58 | MP0001905_abnormal_dopamine_level | 1.02036037 |
| 59 | MP0000647_abnormal_sebaceous_gland | 1.01651623 |
| 60 | MP0005410_abnormal_fertilization | 1.01155897 |
| 61 | MP0001529_abnormal_vocalization | 1.00216547 |
| 62 | MP0001986_abnormal_taste_sensitivity | 0.99559425 |
| 63 | MP0005389_reproductive_system_phenotype | 0.99155780 |
| 64 | MP0005367_renal/urinary_system_phenotyp | 0.97281222 |
| 65 | MP0000516_abnormal_urinary_system | 0.97281222 |
| 66 | MP0003567_abnormal_fetal_cardiomyocyte | 0.96092589 |
| 67 | MP0003763_abnormal_thymus_physiology | 0.94916879 |
| 68 | MP0003111_abnormal_nucleus_morphology | 0.94673649 |
| 69 | MP0000749_muscle_degeneration | 0.94541936 |
| 70 | MP0002163_abnormal_gland_morphology | 0.94537211 |
| 71 | MP0004043_abnormal_pH_regulation | 0.94257311 |
| 72 | MP0005395_other_phenotype | 0.93132129 |
| 73 | MP0000689_abnormal_spleen_morphology | 0.92801292 |
| 74 | MP0002452_abnormal_antigen_presenting | 0.91966421 |
| 75 | MP0002723_abnormal_immune_serum | 0.91476582 |
| 76 | MP0008789_abnormal_olfactory_epithelium | 0.91055160 |
| 77 | MP0001919_abnormal_reproductive_system | 0.90995989 |
| 78 | MP0002019_abnormal_tumor_incidence | 0.90466327 |
| 79 | MP0003436_decreased_susceptibility_to | 0.90278994 |
| 80 | MP0000358_abnormal_cell_content/ | 0.85813965 |
| 81 | MP0001293_anophthalmia | 0.84813351 |
| 82 | MP0001929_abnormal_gametogenesis | 0.84703884 |
| 83 | MP0001819_abnormal_immune_cell | 0.84391435 |
| 84 | MP0004142_abnormal_muscle_tone | 0.84293114 |
| 85 | MP0002420_abnormal_adaptive_immunity | 0.83488825 |
| 86 | MP0000013_abnormal_adipose_tissue | 0.83461198 |
| 87 | MP0008873_increased_physiological_sensi | 0.81787729 |
| 88 | MP0002722_abnormal_immune_system | 0.79850111 |
| 89 | MP0003077_abnormal_cell_cycle | 0.79689838 |
| 90 | MP0008932_abnormal_embryonic_tissue | 0.76184425 |
| 91 | MP0000703_abnormal_thymus_morphology | 0.72984766 |
| 92 | MP0001119_abnormal_female_reproductive | 0.72324027 |
| 93 | MP0001243_abnormal_dermal_layer | 0.71497747 |
| 94 | MP0009046_muscle_twitch | 0.71480310 |
| 95 | MP0002210_abnormal_sex_determination | 0.71470599 |
| 96 | MP0000653_abnormal_sex_gland | 0.69309467 |
| 97 | MP0002398_abnormal_bone_marrow | 0.68999167 |
| 98 | MP0002160_abnormal_reproductive_system | 0.68762654 |
| 99 | MP0005379_endocrine/exocrine_gland_phen | 0.68577235 |
| 100 | MP0008995_early_reproductive_senescence | 0.67913048 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Increased CSF lactate (HP:0002490) | 3.77849820 |
| 2 | Acute necrotizing encephalopathy (HP:0006965) | 3.68531693 |
| 3 | Mitochondrial inheritance (HP:0001427) | 3.61251746 |
| 4 | Increased serum pyruvate (HP:0003542) | 3.52013095 |
| 5 | IgG deficiency (HP:0004315) | 3.50849884 |
| 6 | Acute encephalopathy (HP:0006846) | 3.37979802 |
| 7 | Hepatocellular necrosis (HP:0001404) | 3.37341358 |
| 8 | Abnormality of glycolysis (HP:0004366) | 3.33339619 |
| 9 | Increased serum lactate (HP:0002151) | 3.29593557 |
| 10 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.27811883 |
| 11 | Progressive macrocephaly (HP:0004481) | 3.20611155 |
| 12 | Hypoproteinemia (HP:0003075) | 3.18407409 |
| 13 | Hepatic necrosis (HP:0002605) | 3.01199218 |
| 14 | Increased hepatocellular lipid droplets (HP:0006565) | 3.00971468 |
| 15 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.98329302 |
| 16 | Abnormality of alanine metabolism (HP:0010916) | 2.98329302 |
| 17 | Hyperalaninemia (HP:0003348) | 2.98329302 |
| 18 | Abnormality of B cell number (HP:0010975) | 2.95787411 |
| 19 | Molar tooth sign on MRI (HP:0002419) | 2.88949490 |
| 20 | Abnormality of midbrain morphology (HP:0002418) | 2.88949490 |
| 21 | Abnormality of the renal cortex (HP:0011035) | 2.88023233 |
| 22 | Pancreatic cysts (HP:0001737) | 2.83071471 |
| 23 | Lipid accumulation in hepatocytes (HP:0006561) | 2.81809898 |
| 24 | Renal cortical cysts (HP:0000803) | 2.81094677 |
| 25 | Stomatitis (HP:0010280) | 2.78895255 |
| 26 | Lactic acidosis (HP:0003128) | 2.64275926 |
| 27 | B lymphocytopenia (HP:0010976) | 2.60150847 |
| 28 | Cerebral edema (HP:0002181) | 2.53720944 |
| 29 | Nephronophthisis (HP:0000090) | 2.45136965 |
| 30 | Abolished electroretinogram (ERG) (HP:0000550) | 2.43041364 |
| 31 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.42597657 |
| 32 | Methylmalonic acidemia (HP:0002912) | 2.40017834 |
| 33 | Type I transferrin isoform profile (HP:0003642) | 2.38697969 |
| 34 | Methylmalonic aciduria (HP:0012120) | 2.37201818 |
| 35 | Severe combined immunodeficiency (HP:0004430) | 2.36859548 |
| 36 | Abnormality of T cell physiology (HP:0011840) | 2.36254184 |
| 37 | Renal Fanconi syndrome (HP:0001994) | 2.35435785 |
| 38 | Volvulus (HP:0002580) | 2.34827829 |
| 39 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.34064331 |
| 40 | Congenital stationary night blindness (HP:0007642) | 2.32843658 |
| 41 | Stomach cancer (HP:0012126) | 2.31450575 |
| 42 | Delayed CNS myelination (HP:0002188) | 2.31199646 |
| 43 | True hermaphroditism (HP:0010459) | 2.30626453 |
| 44 | Abnormal protein glycosylation (HP:0012346) | 2.29413963 |
| 45 | Abnormal glycosylation (HP:0012345) | 2.29413963 |
| 46 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.29413963 |
| 47 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.29413963 |
| 48 | Optic disc pallor (HP:0000543) | 2.28728306 |
| 49 | Abnormality of the renal medulla (HP:0100957) | 2.28536419 |
| 50 | Exercise intolerance (HP:0003546) | 2.26926966 |
| 51 | Progressive inability to walk (HP:0002505) | 2.25886370 |
| 52 | 3-Methylglutaconic aciduria (HP:0003535) | 2.23125882 |
| 53 | Type 2 muscle fiber atrophy (HP:0003554) | 2.18294091 |
| 54 | Medial flaring of the eyebrow (HP:0010747) | 2.16717110 |
| 55 | Pancreatic fibrosis (HP:0100732) | 2.16390412 |
| 56 | Respiratory failure (HP:0002878) | 2.15185137 |
| 57 | Progressive microcephaly (HP:0000253) | 2.11072049 |
| 58 | Abnormality of the anterior horn cell (HP:0006802) | 2.10957867 |
| 59 | Degeneration of anterior horn cells (HP:0002398) | 2.10957867 |
| 60 | Hypoplasia of the uterus (HP:0000013) | 2.07841179 |
| 61 | Lethargy (HP:0001254) | 2.03746451 |
| 62 | Tongue fasciculations (HP:0001308) | 2.02053468 |
| 63 | Thyroiditis (HP:0100646) | 2.01871526 |
| 64 | Colon cancer (HP:0003003) | 2.00343258 |
| 65 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.99288020 |
| 66 | Increased intramyocellular lipid droplets (HP:0012240) | 1.98806433 |
| 67 | Type II lissencephaly (HP:0007260) | 1.97350971 |
| 68 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.96555936 |
| 69 | Abnormality of the ileum (HP:0001549) | 1.95700082 |
| 70 | Inability to walk (HP:0002540) | 1.95591424 |
| 71 | Abnormality of T cells (HP:0002843) | 1.93866153 |
| 72 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.91942402 |
| 73 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.91942402 |
| 74 | IgM deficiency (HP:0002850) | 1.91660749 |
| 75 | Constricted visual fields (HP:0001133) | 1.91398159 |
| 76 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.91331518 |
| 77 | Tubular atrophy (HP:0000092) | 1.89966692 |
| 78 | Panhypogammaglobulinemia (HP:0003139) | 1.89485883 |
| 79 | Entropion (HP:0000621) | 1.89412175 |
| 80 | Abnormality of the pons (HP:0007361) | 1.89239022 |
| 81 | Attenuation of retinal blood vessels (HP:0007843) | 1.89179242 |
| 82 | Exertional dyspnea (HP:0002875) | 1.88852049 |
| 83 | Generalized aminoaciduria (HP:0002909) | 1.88035856 |
| 84 | Opisthotonus (HP:0002179) | 1.87914375 |
| 85 | Pendular nystagmus (HP:0012043) | 1.87345475 |
| 86 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.83903738 |
| 87 | Pancytopenia (HP:0001876) | 1.80966025 |
| 88 | Eosinophilia (HP:0001880) | 1.80765818 |
| 89 | Increased IgM level (HP:0003496) | 1.80361126 |
| 90 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.80207211 |
| 91 | Combined immunodeficiency (HP:0005387) | 1.78854063 |
| 92 | Adactyly (HP:0009776) | 1.77878715 |
| 93 | Congenital, generalized hypertrichosis (HP:0004540) | 1.77413657 |
| 94 | Meckel diverticulum (HP:0002245) | 1.77086618 |
| 95 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.76560791 |
| 96 | Large for gestational age (HP:0001520) | 1.75762440 |
| 97 | Abnormality of serum amino acid levels (HP:0003112) | 1.75596672 |
| 98 | Severe muscular hypotonia (HP:0006829) | 1.74718628 |
| 99 | Autoimmune hemolytic anemia (HP:0001890) | 1.72834635 |
| 100 | Glycosuria (HP:0003076) | 1.72779849 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 3.72663006 |
| 2 | ZAK | 2.77477100 |
| 3 | EIF2AK3 | 2.70476352 |
| 4 | MAP4K2 | 2.68486531 |
| 5 | FRK | 2.59364867 |
| 6 | TAOK3 | 2.43599083 |
| 7 | BUB1 | 2.41116365 |
| 8 | TSSK6 | 2.40691991 |
| 9 | NUAK1 | 2.36210111 |
| 10 | MST4 | 2.35358774 |
| 11 | VRK1 | 2.25181970 |
| 12 | TXK | 2.16812500 |
| 13 | ADRBK2 | 2.16159643 |
| 14 | BMPR1B | 2.02873820 |
| 15 | EIF2AK1 | 1.98642221 |
| 16 | TLK1 | 1.93787698 |
| 17 | SRPK1 | 1.84549789 |
| 18 | TRIM28 | 1.82025733 |
| 19 | NEK1 | 1.80670864 |
| 20 | PLK3 | 1.79935905 |
| 21 | PLK2 | 1.72166298 |
| 22 | BCKDK | 1.59419280 |
| 23 | TESK2 | 1.54707317 |
| 24 | PLK4 | 1.49869485 |
| 25 | BCR | 1.49067613 |
| 26 | PBK | 1.41661855 |
| 27 | MAP3K12 | 1.31681750 |
| 28 | GRK1 | 1.30981586 |
| 29 | EIF2AK2 | 1.29077441 |
| 30 | WNK3 | 1.27864395 |
| 31 | DAPK1 | 1.24630946 |
| 32 | WNK4 | 1.24104020 |
| 33 | CSNK1G3 | 1.21651098 |
| 34 | PINK1 | 1.15647275 |
| 35 | PDK2 | 1.13632978 |
| 36 | SCYL2 | 1.13100891 |
| 37 | KDR | 1.09095629 |
| 38 | CDK8 | 1.08500265 |
| 39 | NME1 | 1.08319917 |
| 40 | CSNK1A1L | 1.07813206 |
| 41 | CCNB1 | 1.06663527 |
| 42 | CSNK1G1 | 1.03953186 |
| 43 | FLT3 | 1.01451310 |
| 44 | TEC | 0.94788470 |
| 45 | TNIK | 0.94138753 |
| 46 | PHKG1 | 0.93447422 |
| 47 | PHKG2 | 0.93447422 |
| 48 | STK39 | 0.93128871 |
| 49 | TGFBR1 | 0.92547216 |
| 50 | LIMK1 | 0.90470508 |
| 51 | STK16 | 0.89676991 |
| 52 | CSNK1G2 | 0.89147959 |
| 53 | KIT | 0.87688225 |
| 54 | OXSR1 | 0.87254766 |
| 55 | TESK1 | 0.86165578 |
| 56 | IKBKB | 0.84986888 |
| 57 | MKNK2 | 0.84879905 |
| 58 | MAPKAPK3 | 0.83652957 |
| 59 | GRK5 | 0.79858173 |
| 60 | MUSK | 0.76672957 |
| 61 | MKNK1 | 0.76368526 |
| 62 | TAF1 | 0.75188546 |
| 63 | ERBB3 | 0.74735401 |
| 64 | MAPKAPK5 | 0.67292718 |
| 65 | MAP2K7 | 0.66973315 |
| 66 | MAPK13 | 0.66819085 |
| 67 | PRKCE | 0.63822027 |
| 68 | ATR | 0.63317148 |
| 69 | PLK1 | 0.63198726 |
| 70 | ADRBK1 | 0.63046005 |
| 71 | PTK2B | 0.62106758 |
| 72 | CAMKK2 | 0.61204290 |
| 73 | PRKCI | 0.60529485 |
| 74 | TTK | 0.60130796 |
| 75 | ITK | 0.59825534 |
| 76 | INSRR | 0.58309851 |
| 77 | IKBKE | 0.57567565 |
| 78 | ACVR1B | 0.56964417 |
| 79 | GRK7 | 0.52736568 |
| 80 | RPS6KA5 | 0.50490360 |
| 81 | MAP3K4 | 0.49602925 |
| 82 | MAP3K14 | 0.49141382 |
| 83 | PIK3CG | 0.48816406 |
| 84 | PIM2 | 0.47382818 |
| 85 | MAP2K6 | 0.46477046 |
| 86 | AURKB | 0.45676680 |
| 87 | GRK6 | 0.44846150 |
| 88 | BRSK2 | 0.42374748 |
| 89 | AURKA | 0.41267581 |
| 90 | CDC7 | 0.38665916 |
| 91 | STK10 | 0.36213031 |
| 92 | CSNK1A1 | 0.35627596 |
| 93 | ATM | 0.35574504 |
| 94 | CLK1 | 0.35197082 |
| 95 | ABL1 | 0.34567368 |
| 96 | SYK | 0.34562904 |
| 97 | MAP4K1 | 0.33650598 |
| 98 | MYLK | 0.32637074 |
| 99 | IGF1R | 0.31667826 |
| 100 | SIK3 | 0.31363657 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.48471758 |
| 2 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.82842389 |
| 3 | Protein export_Homo sapiens_hsa03060 | 2.74433202 |
| 4 | RNA polymerase_Homo sapiens_hsa03020 | 2.49725480 |
| 5 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.43617449 |
| 6 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.27067015 |
| 7 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.25440778 |
| 8 | Mismatch repair_Homo sapiens_hsa03430 | 2.04155480 |
| 9 | Homologous recombination_Homo sapiens_hsa03440 | 2.00781415 |
| 10 | Parkinsons disease_Homo sapiens_hsa05012 | 2.00206904 |
| 11 | DNA replication_Homo sapiens_hsa03030 | 1.93326717 |
| 12 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.91299903 |
| 13 | RNA degradation_Homo sapiens_hsa03018 | 1.88364050 |
| 14 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.86944222 |
| 15 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.85727405 |
| 16 | Base excision repair_Homo sapiens_hsa03410 | 1.84566833 |
| 17 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.82660598 |
| 18 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.61643674 |
| 19 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.60917055 |
| 20 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.59313963 |
| 21 | Basal transcription factors_Homo sapiens_hsa03022 | 1.59012280 |
| 22 | Asthma_Homo sapiens_hsa05310 | 1.55806902 |
| 23 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.50972076 |
| 24 | Allograft rejection_Homo sapiens_hsa05330 | 1.50920681 |
| 25 | Phototransduction_Homo sapiens_hsa04744 | 1.47017152 |
| 26 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.46385398 |
| 27 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.45587816 |
| 28 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.42881026 |
| 29 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.42412561 |
| 30 | RNA transport_Homo sapiens_hsa03013 | 1.38766878 |
| 31 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.35513735 |
| 32 | Purine metabolism_Homo sapiens_hsa00230 | 1.31042623 |
| 33 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.30839734 |
| 34 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.30402409 |
| 35 | Spliceosome_Homo sapiens_hsa03040 | 1.26400235 |
| 36 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.25822097 |
| 37 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.23789885 |
| 38 | Huntingtons disease_Homo sapiens_hsa05016 | 1.23595767 |
| 39 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.19825776 |
| 40 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.16871105 |
| 41 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.14156974 |
| 42 | Alzheimers disease_Homo sapiens_hsa05010 | 1.13401474 |
| 43 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.11361826 |
| 44 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.11086153 |
| 45 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.09200710 |
| 46 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.03130948 |
| 47 | Peroxisome_Homo sapiens_hsa04146 | 1.01429341 |
| 48 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.99620852 |
| 49 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.98811797 |
| 50 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.96508950 |
| 51 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.96488463 |
| 52 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.92935574 |
| 53 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.91403397 |
| 54 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.86071976 |
| 55 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.80376803 |
| 56 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.76076157 |
| 57 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.75783724 |
| 58 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.74880911 |
| 59 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.74566876 |
| 60 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.73345286 |
| 61 | Carbon metabolism_Homo sapiens_hsa01200 | 0.72927650 |
| 62 | Sulfur relay system_Homo sapiens_hsa04122 | 0.72327267 |
| 63 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.72241525 |
| 64 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.70252691 |
| 65 | Metabolic pathways_Homo sapiens_hsa01100 | 0.70155206 |
| 66 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.67322893 |
| 67 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.66807192 |
| 68 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.66134835 |
| 69 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.65696555 |
| 70 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.65672381 |
| 71 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.62740982 |
| 72 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.61155284 |
| 73 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.59844928 |
| 74 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.58243844 |
| 75 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.58036317 |
| 76 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.57060532 |
| 77 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.56404873 |
| 78 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.54528203 |
| 79 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.51745372 |
| 80 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.51549114 |
| 81 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.51041854 |
| 82 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.50206813 |
| 83 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.50170125 |
| 84 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.48908205 |
| 85 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.47562024 |
| 86 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.46898271 |
| 87 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.46710122 |
| 88 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.45436523 |
| 89 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.43509162 |
| 90 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.43339608 |
| 91 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.42077857 |
| 92 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.40575412 |
| 93 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.39731400 |
| 94 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.37325120 |
| 95 | Viral myocarditis_Homo sapiens_hsa05416 | 0.37157415 |
| 96 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.35816077 |
| 97 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.34737228 |
| 98 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.33044950 |
| 99 | Ribosome_Homo sapiens_hsa03010 | 0.33002373 |
| 100 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.32705064 |

