LDHAP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.15410354
2oligosaccharide biosynthetic process (GO:0009312)7.00550739
3cytidine metabolic process (GO:0046087)5.80031053
4cytidine catabolic process (GO:0006216)5.80031053
5cytidine deamination (GO:0009972)5.80031053
6negative regulation of nitric-oxide synthase activity (GO:0051001)5.52176001
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.15193663
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.10332983
9pyrimidine ribonucleoside catabolic process (GO:0046133)5.02366529
10energy coupled proton transport, down electrochemical gradient (GO:0015985)4.82901676
11ATP synthesis coupled proton transport (GO:0015986)4.82901676
12protein complex biogenesis (GO:0070271)4.18190651
13positive regulation of fatty acid beta-oxidation (GO:0032000)4.16213408
14regulation of skeletal muscle contraction (GO:0014819)4.12792739
15ribosomal small subunit assembly (GO:0000028)4.12128499
16organelle disassembly (GO:1903008)4.03854810
17negative regulation of monooxygenase activity (GO:0032769)4.01356834
18platelet dense granule organization (GO:0060155)4.00402360
19positive regulation of fatty acid oxidation (GO:0046321)3.95810244
20mitochondrial respiratory chain complex I assembly (GO:0032981)3.95123789
21NADH dehydrogenase complex assembly (GO:0010257)3.95123789
22mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.95123789
23proteasome assembly (GO:0043248)3.92164301
24rRNA modification (GO:0000154)3.90791578
25activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.79514540
26regulation of sarcomere organization (GO:0060297)3.78178835
27mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.75821021
28protein neddylation (GO:0045116)3.75015158
29respiratory electron transport chain (GO:0022904)3.74931382
30iron-sulfur cluster assembly (GO:0016226)3.74579056
31metallo-sulfur cluster assembly (GO:0031163)3.74579056
32mitochondrial respiratory chain complex assembly (GO:0033108)3.74384983
33ribonucleoprotein complex disassembly (GO:0032988)3.74102852
34electron transport chain (GO:0022900)3.66370045
35regulation of cellular amino acid metabolic process (GO:0006521)3.63845232
36negative regulation of smooth muscle cell differentiation (GO:0051151)3.58688701
37DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.46321978
38negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.42906778
39signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.35606286
40signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.35606286
41signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.35606286
42signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.34545584
43intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.34545584
44aldehyde catabolic process (GO:0046185)3.32119214
45rRNA methylation (GO:0031167)3.26271166
46nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.20823919
47signal transduction involved in DNA damage checkpoint (GO:0072422)3.16355571
48signal transduction involved in DNA integrity checkpoint (GO:0072401)3.16355571
49negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.16231107
50negative regulation of ligase activity (GO:0051352)3.16231107
51exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.16169404
52positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.12600430
53negative regulation of muscle hypertrophy (GO:0014741)3.11894246
54maturation of SSU-rRNA (GO:0030490)3.11770122
55water-soluble vitamin biosynthetic process (GO:0042364)3.10907490
56transcription elongation from RNA polymerase III promoter (GO:0006385)3.10727291
57termination of RNA polymerase III transcription (GO:0006386)3.10727291
58negative regulation of organelle assembly (GO:1902116)3.10681209
59signal transduction involved in cell cycle checkpoint (GO:0072395)3.10416473
60phosphatidylinositol acyl-chain remodeling (GO:0036149)3.09767994
61mannosylation (GO:0097502)3.09410716
62oxidative phosphorylation (GO:0006119)3.07601433
63cytochrome complex assembly (GO:0017004)3.04726167
64membrane raft organization (GO:0031579)3.04489274
65postreplication repair (GO:0006301)3.02162246
66deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.98480469
67behavioral response to nicotine (GO:0035095)2.97741395
68preassembly of GPI anchor in ER membrane (GO:0016254)2.97021890
69regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.90936571
70antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.90206619
71dopamine transport (GO:0015872)2.89674245
72negative regulation of T cell differentiation in thymus (GO:0033085)2.86213546
73prenylation (GO:0097354)2.84930617
74protein prenylation (GO:0018342)2.84930617
75positive T cell selection (GO:0043368)2.83141965
76regulation of regulatory T cell differentiation (GO:0045589)2.82685783
77ATP biosynthetic process (GO:0006754)2.82000760
78respiratory chain complex IV assembly (GO:0008535)2.76000834
79regulation of isotype switching to IgG isotypes (GO:0048302)2.74989087
80regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.74737491
81positive regulation of T cell apoptotic process (GO:0070234)2.74218250
82positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.73960026
83positive regulation of cell cycle arrest (GO:0071158)2.73199535
84establishment of protein localization to mitochondrial membrane (GO:0090151)2.72376728
85negative regulation of oxidoreductase activity (GO:0051354)2.69400485
86negative regulation of protein localization to cell surface (GO:2000009)2.69098005
87negative T cell selection (GO:0043383)2.68800241
88anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.68687907
89antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.66802756
90translational elongation (GO:0006414)2.65050432
91S-adenosylmethionine metabolic process (GO:0046500)2.62422498
92hydrogen ion transmembrane transport (GO:1902600)2.60040947
93regulation of chronic inflammatory response (GO:0002676)2.58214208
94translation (GO:0006412)2.58180823
95positive regulation of ligase activity (GO:0051351)2.57403496
96GPI anchor biosynthetic process (GO:0006506)2.57263801
97regulation of histone phosphorylation (GO:0033127)2.56806411
98L-fucose catabolic process (GO:0042355)2.56792106
99fucose catabolic process (GO:0019317)2.56792106
100L-fucose metabolic process (GO:0042354)2.56792106

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.42066871
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.35875687
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.28798735
4VDR_22108803_ChIP-Seq_LS180_Human4.27803334
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.72172134
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.55027739
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.30400600
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.10523135
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.94950304
10ZNF274_21170338_ChIP-Seq_K562_Hela2.88181800
11VDR_23849224_ChIP-Seq_CD4+_Human2.61370727
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.61139669
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.56838279
14IGF1R_20145208_ChIP-Seq_DFB_Human2.55370955
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.48209752
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.46414864
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.41740469
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.35130919
19RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15917845
20FOXP3_21729870_ChIP-Seq_TREG_Human2.14359539
21IRF8_22096565_ChIP-ChIP_GC-B_Human2.10778347
22ELK1_19687146_ChIP-ChIP_HELA_Human1.98455532
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.97532460
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.97017923
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.92127882
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.85105174
27MYC_18555785_ChIP-Seq_MESCs_Mouse1.83546743
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79830089
29MYC_18940864_ChIP-ChIP_HL60_Human1.75736541
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.63837508
31GATA3_26560356_Chip-Seq_TH2_Human1.61563417
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56669102
33STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.54300911
34CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.53871152
35HTT_18923047_ChIP-ChIP_STHdh_Human1.52050047
36ERG_20517297_ChIP-Seq_VCAP_Human1.49868412
37FOXA1_27270436_Chip-Seq_PROSTATE_Human1.47109076
38FOXA1_25329375_ChIP-Seq_VCAP_Human1.47109076
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45671997
40PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.42946502
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42310213
42NCOR_22424771_ChIP-Seq_293T_Human1.40295460
43NANOG_19829295_ChIP-Seq_ESCs_Human1.39641781
44SOX2_19829295_ChIP-Seq_ESCs_Human1.39641781
45IRF1_19129219_ChIP-ChIP_H3396_Human1.39008397
46MYC_18358816_ChIP-ChIP_MESCs_Mouse1.38376356
47PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.37749918
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.37314351
49E2F4_17652178_ChIP-ChIP_JURKAT_Human1.35666505
50TP53_22573176_ChIP-Seq_HFKS_Human1.35659584
51GATA3_21878914_ChIP-Seq_MCF-7_Human1.32604418
52MYB_26560356_Chip-Seq_TH2_Human1.32095251
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31461204
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.31452558
55EGR1_23403033_ChIP-Seq_LIVER_Mouse1.30574734
56AR_20517297_ChIP-Seq_VCAP_Human1.30056881
57ELK1_22589737_ChIP-Seq_MCF10A_Human1.26525709
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25129212
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20566171
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18246248
61KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.16544571
62KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.16544571
63KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.16544571
64AR_21572438_ChIP-Seq_LNCaP_Human1.15305621
65TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.13309261
66EWS_26573619_Chip-Seq_HEK293_Human1.13110889
67RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.12253087
68EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.08676203
69STAT4_19710469_ChIP-ChIP_TH1__Mouse1.08532238
70GATA6_21074721_ChIP-Seq_CACO-2_Human1.06796882
71MYC_19829295_ChIP-Seq_ESCs_Human1.05720470
72RBPJ_21746931_ChIP-Seq_IB4_Human1.05557634
73CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.05095914
74TAF2_19829295_ChIP-Seq_ESCs_Human1.05055143
75GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.03257166
76GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.02843959
77SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02600848
78GABP_19822575_ChIP-Seq_HepG2_Human1.02565543
79ER_23166858_ChIP-Seq_MCF-7_Human1.02433414
80HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01706433
81PHF8_20622853_ChIP-Seq_HELA_Human0.99749468
82CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99022822
83LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98970745
84POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98174017
85NANOG_20526341_ChIP-Seq_ESCs_Human0.97649625
86POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97608429
87CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.97488272
88RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.97303305
89EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.96655731
90FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.95984870
91IRF8_21731497_ChIP-ChIP_J774_Mouse0.94661121
92DCP1A_22483619_ChIP-Seq_HELA_Human0.94400432
93E2F1_18555785_ChIP-Seq_MESCs_Mouse0.93803493
94CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93212831
95CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93093749
96CBX2_22325352_ChIP-Seq_293T-Rex_Human0.92084522
97MYC_19030024_ChIP-ChIP_MESCs_Mouse0.91452455
98ETV1_20927104_ChIP-Seq_GIST48_Human0.91151269
99FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90588176
100PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.87800091

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001873_stomach_inflammation4.96925056
2MP0005671_abnormal_response_to4.78398955
3MP0003950_abnormal_plasma_membrane4.50145369
4MP0004145_abnormal_muscle_electrophysio2.96050612
5MP0002102_abnormal_ear_morphology2.72945624
6MP0003806_abnormal_nucleotide_metabolis2.55581322
7MP0009333_abnormal_splenocyte_physiolog2.36814541
8MP0001835_abnormal_antigen_presentation2.32949660
9MP0003786_premature_aging2.25501473
10MP0008872_abnormal_physiological_respon2.12658097
11MP0002837_dystrophic_cardiac_calcinosis2.12396012
12MP0004147_increased_porphyrin_level2.07989367
13MP0000685_abnormal_immune_system2.07029155
14MP0009785_altered_susceptibility_to2.05476522
15MP0003763_abnormal_thymus_physiology2.04105659
16MP0003011_delayed_dark_adaptation1.95356996
17MP0008875_abnormal_xenobiotic_pharmacok1.85141586
18MP0000749_muscle_degeneration1.84901026
19MP0002933_joint_inflammation1.81503102
20MP0003195_calcinosis1.79587726
21MP0002148_abnormal_hypersensitivity_rea1.78872000
22MP0001800_abnormal_humoral_immune1.76019486
23MP0003646_muscle_fatigue1.68298826
24MP0005646_abnormal_pituitary_gland1.67822020
25MP0002166_altered_tumor_susceptibility1.67793598
26MP0005000_abnormal_immune_tolerance1.66190613
27MP0008995_early_reproductive_senescence1.59006970
28MP0005360_urolithiasis1.55150017
29MP0006036_abnormal_mitochondrial_physio1.50957180
30MP0001764_abnormal_homeostasis1.47774018
31MP0002277_abnormal_respiratory_mucosa1.46973389
32MP0003186_abnormal_redox_activity1.44955955
33MP0006082_CNS_inflammation1.43240369
34MP0002723_abnormal_immune_serum1.40686784
35MP0003283_abnormal_digestive_organ1.39496253
36MP0003693_abnormal_embryo_hatching1.38511017
37MP0002006_tumorigenesis1.37614322
38MP0001790_abnormal_immune_system1.36673496
39MP0005387_immune_system_phenotype1.36673496
40MP0000372_irregular_coat_pigmentation1.36455208
41MP0005084_abnormal_gallbladder_morpholo1.34328121
42MP0002420_abnormal_adaptive_immunity1.29505084
43MP0005330_cardiomyopathy1.25235989
44MP0001819_abnormal_immune_cell1.24143596
45MP0002452_abnormal_antigen_presenting1.19743097
46MP0005551_abnormal_eye_electrophysiolog1.18654835
47MP0006072_abnormal_retinal_apoptosis1.18169411
48MP0009379_abnormal_foot_pigmentation1.16949495
49MP0010386_abnormal_urinary_bladder1.14765281
50MP0008789_abnormal_olfactory_epithelium1.13970152
51MP0002693_abnormal_pancreas_physiology1.12852845
52MP0001542_abnormal_bone_strength1.11837799
53MP0002163_abnormal_gland_morphology1.11709866
54MP0004142_abnormal_muscle_tone1.11595868
55MP0006035_abnormal_mitochondrial_morpho1.11567311
56MP0003567_abnormal_fetal_cardiomyocyte1.07813917
57MP0005310_abnormal_salivary_gland1.03144527
58MP0001485_abnormal_pinna_reflex1.02668709
59MP0005389_reproductive_system_phenotype1.02425444
60MP0001853_heart_inflammation1.02071009
61MP0000716_abnormal_immune_system1.01631845
62MP0005379_endocrine/exocrine_gland_phen1.00261431
63MP0005025_abnormal_response_to0.97825919
64MP0003866_abnormal_defecation0.97020876
65MP0002398_abnormal_bone_marrow0.95675648
66MP0002095_abnormal_skin_pigmentation0.94724191
67MP0001919_abnormal_reproductive_system0.93063190
68MP0008469_abnormal_protein_level0.91802667
69MP0002405_respiratory_system_inflammati0.90492323
70MP0002160_abnormal_reproductive_system0.90374232
71MP0001845_abnormal_inflammatory_respons0.88872515
72MP0001529_abnormal_vocalization0.87849369
73MP0003137_abnormal_impulse_conducting0.86164070
74MP0000689_abnormal_spleen_morphology0.85283374
75MP0003448_altered_tumor_morphology0.83756007
76MP0001348_abnormal_lacrimal_gland0.83745005
77MP0005645_abnormal_hypothalamus_physiol0.80911868
78MP0004885_abnormal_endolymph0.80715975
79MP0008058_abnormal_DNA_repair0.80458533
80MP0002429_abnormal_blood_cell0.80237003
81MP0001663_abnormal_digestive_system0.80162050
82MP0001986_abnormal_taste_sensitivity0.78616572
83MP0005083_abnormal_biliary_tract0.78346605
84MP0005187_abnormal_penis_morphology0.76974581
85MP0010368_abnormal_lymphatic_system0.76070278
86MP0009763_increased_sensitivity_to0.75382457
87MP0005166_decreased_susceptibility_to0.74404384
88MP0005332_abnormal_amino_acid0.73687792
89MP0008961_abnormal_basal_metabolism0.73247351
90MP0001664_abnormal_digestion0.73079426
91MP0002234_abnormal_pharynx_morphology0.72697337
92MP0002019_abnormal_tumor_incidence0.71978588
93MP0004742_abnormal_vestibular_system0.70488355
94MP0002722_abnormal_immune_system0.70395682
95MP0001968_abnormal_touch/_nociception0.69185437
96MP0003045_fibrosis0.69169871
97MP0005253_abnormal_eye_physiology0.68961447
98MP0000703_abnormal_thymus_morphology0.68206489
99MP0010155_abnormal_intestine_physiology0.66167005
100MP0000647_abnormal_sebaceous_gland0.64718301

Predicted human phenotypes

RankGene SetZ-score
1Renal cortical cysts (HP:0000803)4.86253426
2Acute necrotizing encephalopathy (HP:0006965)4.79937559
3Acute encephalopathy (HP:0006846)4.17349002
4Progressive macrocephaly (HP:0004481)4.08498268
5Abnormal mitochondria in muscle tissue (HP:0008316)4.01492668
6Calf muscle hypertrophy (HP:0008981)4.00675520
7Mitochondrial inheritance (HP:0001427)3.98345509
8Muscle hypertrophy of the lower extremities (HP:0008968)3.50270526
9Brushfield spots (HP:0001088)3.48249203
10Abnormality of the renal cortex (HP:0011035)3.44201462
11Increased CSF lactate (HP:0002490)3.38639047
12Elevated erythrocyte sedimentation rate (HP:0003565)3.14372179
13Optic disc pallor (HP:0000543)3.03205644
14Increased hepatocellular lipid droplets (HP:0006565)3.02382083
15Pendular nystagmus (HP:0012043)3.01996022
16Hepatocellular necrosis (HP:0001404)3.00930306
17Large for gestational age (HP:0001520)3.00384319
18Exercise-induced muscle cramps (HP:0003710)2.99268662
19Renal Fanconi syndrome (HP:0001994)2.97268210
20Congenital stationary night blindness (HP:0007642)2.95203028
21Decreased activity of mitochondrial respiratory chain (HP:0008972)2.92230128
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.92230128
233-Methylglutaconic aciduria (HP:0003535)2.89983491
24Cerebral edema (HP:0002181)2.85815643
25Absent rod-and cone-mediated responses on ERG (HP:0007688)2.80026466
26Abnormality of T cell number (HP:0011839)2.76847124
27Abnormal number of erythroid precursors (HP:0012131)2.75913905
28Decreased central vision (HP:0007663)2.74458844
29Hepatic necrosis (HP:0002605)2.74073148
30Lipid accumulation in hepatocytes (HP:0006561)2.73007385
31Increased serum pyruvate (HP:0003542)2.71099315
32Aplastic anemia (HP:0001915)2.70584786
33Type I transferrin isoform profile (HP:0003642)2.69803366
34Myotonia (HP:0002486)2.67771079
35Attenuation of retinal blood vessels (HP:0007843)2.67029328
36Abnormality of alanine metabolism (HP:0010916)2.66064118
37Hyperalaninemia (HP:0003348)2.66064118
38Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.66064118
39Type 2 muscle fiber atrophy (HP:0003554)2.65175406
40Congenital, generalized hypertrichosis (HP:0004540)2.62765070
41T lymphocytopenia (HP:0005403)2.49357700
42Increased serum lactate (HP:0002151)2.48569405
43Hypoplasia of the thymus (HP:0000778)2.46817560
44Increased intramyocellular lipid droplets (HP:0012240)2.46101130
45Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.45850499
46Abnormality of cells of the erythroid lineage (HP:0012130)2.45006652
47Increased corneal curvature (HP:0100692)2.43532728
48Keratoconus (HP:0000563)2.43532728
49Pancreatic cysts (HP:0001737)2.42005685
50Type II lissencephaly (HP:0007260)2.34548591
51Autoimmune hemolytic anemia (HP:0001890)2.34327261
52Increased IgM level (HP:0003496)2.28145845
53Leukodystrophy (HP:0002415)2.28004923
54Abnormality of glycolysis (HP:0004366)2.27956590
55IgG deficiency (HP:0004315)2.27269127
56Stomatitis (HP:0010280)2.25068807
57Abnormality of the prostate (HP:0008775)2.25036946
58Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.24982727
59Exertional dyspnea (HP:0002875)2.24560819
60Abnormality of T cells (HP:0002843)2.23119671
61Hypoproteinemia (HP:0003075)2.21046449
62Exercise intolerance (HP:0003546)2.20469816
63Lactic acidosis (HP:0003128)2.17812135
64Abnormality of B cell number (HP:0010975)2.17536368
65Muscle fiber atrophy (HP:0100295)2.15302793
66Respiratory failure (HP:0002878)2.14965175
67Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.06503552
68Abnormal protein N-linked glycosylation (HP:0012347)2.06503552
69Abnormal protein glycosylation (HP:0012346)2.06503552
70Abnormal glycosylation (HP:0012345)2.06503552
71Abnormality of the left ventricular outflow tract (HP:0011103)2.05781464
72Subaortic stenosis (HP:0001682)2.05781464
73Cerebellar dysplasia (HP:0007033)2.05290039
74Hyperglycinuria (HP:0003108)2.04081037
75Abnormal rod and cone electroretinograms (HP:0008323)2.01542651
76Muscle stiffness (HP:0003552)2.00766327
77Generalized aminoaciduria (HP:0002909)2.00197206
78Molar tooth sign on MRI (HP:0002419)1.97050215
79Abnormality of midbrain morphology (HP:0002418)1.97050215
80Hyperglycinemia (HP:0002154)1.96858490
81Increased muscle lipid content (HP:0009058)1.96240103
82True hermaphroditism (HP:0010459)1.96118279
83Abnormality of the anterior horn cell (HP:0006802)1.95009614
84Degeneration of anterior horn cells (HP:0002398)1.95009614
85Metabolic alkalosis (HP:0200114)1.91766201
86Hypoplasia of the uterus (HP:0000013)1.90091926
87Recurrent corneal erosions (HP:0000495)1.88863080
88Lethargy (HP:0001254)1.87861622
89Aplasia/hypoplasia of the uterus (HP:0008684)1.86283026
90Pancytopenia (HP:0001876)1.85667586
91Glycosuria (HP:0003076)1.84517633
92Abnormality of urine glucose concentration (HP:0011016)1.84517633
93Exercise-induced myalgia (HP:0003738)1.84294884
94Hypokalemic alkalosis (HP:0001949)1.84010289
95Abnormality of the heme biosynthetic pathway (HP:0010472)1.80669726
96Pancreatic fibrosis (HP:0100732)1.80633212
97Prolonged QT interval (HP:0001657)1.79693556
98Palpebral edema (HP:0100540)1.79202020
99Microretrognathia (HP:0000308)1.75193217
100Severe combined immunodeficiency (HP:0004430)1.74636000

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR6.39403148
2TXK4.58188154
3MUSK4.47207571
4VRK23.15291758
5TAOK32.53948948
6KDR2.39239437
7ZAK2.37268666
8PBK2.29868396
9VRK12.18906225
10MAPKAPK52.14721130
11TESK22.07655824
12NUAK12.04996724
13CDK81.95491088
14WNK41.89897383
15BMPR21.83127212
16MAP3K121.82091242
17GRK11.64218499
18TLK11.56548669
19ITK1.53766531
20ADRBK21.49702442
21CCNB11.45915805
22TNK21.43239033
23MAP4K11.40737547
24CAMKK21.39242066
25STK391.36549086
26TEC1.30559061
27BUB11.27759481
28SCYL21.25034522
29PLK41.19351405
30BMPR1B1.15330215
31EIF2AK31.07989334
32OXSR11.05289457
33CSF1R1.03420849
34BRSK21.01871096
35ADRBK10.99635153
36NEK90.99051917
37MELK0.96371389
38MAP4K20.95360982
39MST40.95277659
40EIF2AK10.94486570
41PIK3CA0.94177093
42MAP2K60.92732847
43PINK10.91117634
44RPS6KA50.85268906
45PIK3CG0.81915358
46BCKDK0.80405968
47DAPK10.79775022
48MAP3K100.78405436
49FRK0.77644978
50DAPK20.76952133
51IKBKB0.70300407
52NTRK10.68510292
53FLT30.68059790
54LCK0.66100176
55ILK0.65303554
56PLK30.64474238
57NME20.63351584
58SYK0.62901860
59TSSK60.61393859
60MYLK0.56989573
61GRK70.55913762
62BRSK10.54336534
63PRKCQ0.49231535
64CLK10.49047168
65IGF1R0.46207051
66WNK30.46036298
67RPS6KA40.45056758
68GRK50.44847860
69STK160.43484327
70LIMK10.41484829
71ERBB30.41481064
72STK40.40291066
73ZAP700.40085160
74MAP3K50.38973839
75NEK10.38722049
76PAK60.35725908
77PLK20.35510948
78DAPK30.33598493
79MAP2K20.32620366
80NME10.31818339
81CAMKK10.30684686
82PLK10.30450208
83CAMK2A0.30349139
84MAP3K110.30083392
85TIE10.29157384
86CSNK1G30.28658627
87KIT0.26633756
88OBSCN0.26560709
89MKNK10.25507642
90PRKACA0.25100043
91PRKCA0.24886820
92BTK0.24629075
93CDK90.24599008
94TAF10.24118761
95PRKCE0.23531653
96LYN0.22936757
97ABL10.22708863
98GRK60.22518254
99ABL20.22451472
100CSNK2A20.22298042

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.65189638
2Oxidative phosphorylation_Homo sapiens_hsa001903.62337891
3Ribosome_Homo sapiens_hsa030103.22213224
4Parkinsons disease_Homo sapiens_hsa050123.18454056
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.14193015
6Primary immunodeficiency_Homo sapiens_hsa053402.60244176
7RNA polymerase_Homo sapiens_hsa030202.30036899
8Protein export_Homo sapiens_hsa030602.24480983
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.19452640
10Autoimmune thyroid disease_Homo sapiens_hsa053202.17891782
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.08390196
12Alzheimers disease_Homo sapiens_hsa050102.04935022
13Allograft rejection_Homo sapiens_hsa053302.04363499
14Linoleic acid metabolism_Homo sapiens_hsa005911.99243026
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.94072900
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.90663517
17One carbon pool by folate_Homo sapiens_hsa006701.90399460
18Huntingtons disease_Homo sapiens_hsa050161.89658560
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.79263862
20Graft-versus-host disease_Homo sapiens_hsa053321.79162093
21RNA degradation_Homo sapiens_hsa030181.72950296
22Asthma_Homo sapiens_hsa053101.62348557
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.57212536
24Ether lipid metabolism_Homo sapiens_hsa005651.54941403
25Cardiac muscle contraction_Homo sapiens_hsa042601.49634554
26Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.49495349
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.48790091
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.47640000
29Peroxisome_Homo sapiens_hsa041461.47573888
30Sulfur relay system_Homo sapiens_hsa041221.42813003
31Pyrimidine metabolism_Homo sapiens_hsa002401.39424219
32Phototransduction_Homo sapiens_hsa047441.37601469
33Antigen processing and presentation_Homo sapiens_hsa046121.27652910
34Selenocompound metabolism_Homo sapiens_hsa004501.25709452
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.24626616
36Type I diabetes mellitus_Homo sapiens_hsa049401.19872935
37Hematopoietic cell lineage_Homo sapiens_hsa046401.17313370
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.06891868
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03866638
40Propanoate metabolism_Homo sapiens_hsa006401.03852216
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03023596
42Arachidonic acid metabolism_Homo sapiens_hsa005901.02846434
43Retinol metabolism_Homo sapiens_hsa008301.02314523
44Homologous recombination_Homo sapiens_hsa034400.98754476
45Mismatch repair_Homo sapiens_hsa034300.98690803
46Rheumatoid arthritis_Homo sapiens_hsa053230.97618122
47Butanoate metabolism_Homo sapiens_hsa006500.96580371
48T cell receptor signaling pathway_Homo sapiens_hsa046600.95943715
49Systemic lupus erythematosus_Homo sapiens_hsa053220.89644530
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.89582852
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.88897347
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88209719
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.86664233
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.85017920
55Pyruvate metabolism_Homo sapiens_hsa006200.83988817
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.82278420
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81947975
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80984857
59DNA replication_Homo sapiens_hsa030300.78394771
60Purine metabolism_Homo sapiens_hsa002300.77579884
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75637486
62Chemical carcinogenesis_Homo sapiens_hsa052040.74394891
63RNA transport_Homo sapiens_hsa030130.73244169
64Spliceosome_Homo sapiens_hsa030400.71078348
65Metabolic pathways_Homo sapiens_hsa011000.67237635
66Viral myocarditis_Homo sapiens_hsa054160.65606546
67Measles_Homo sapiens_hsa051620.65590477
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63763249
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63062453
70Folate biosynthesis_Homo sapiens_hsa007900.59698574
71Basal transcription factors_Homo sapiens_hsa030220.58651648
72Nucleotide excision repair_Homo sapiens_hsa034200.57959312
73Nitrogen metabolism_Homo sapiens_hsa009100.54552296
74Tryptophan metabolism_Homo sapiens_hsa003800.54071418
75Fanconi anemia pathway_Homo sapiens_hsa034600.53694778
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.49012009
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48578207
78p53 signaling pathway_Homo sapiens_hsa041150.45149480
79ABC transporters_Homo sapiens_hsa020100.38328699
80Taste transduction_Homo sapiens_hsa047420.37411161
81NF-kappa B signaling pathway_Homo sapiens_hsa040640.36412914
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36139464
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.31122606
84Arginine and proline metabolism_Homo sapiens_hsa003300.30659394
85Fat digestion and absorption_Homo sapiens_hsa049750.29316177
86Ovarian steroidogenesis_Homo sapiens_hsa049130.28980246
87Base excision repair_Homo sapiens_hsa034100.28170191
88Caffeine metabolism_Homo sapiens_hsa002320.25718115
89Collecting duct acid secretion_Homo sapiens_hsa049660.24613819
90Fatty acid elongation_Homo sapiens_hsa000620.23921313
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.19970007
92Olfactory transduction_Homo sapiens_hsa047400.19462839
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19427884
94N-Glycan biosynthesis_Homo sapiens_hsa005100.19040600
95Glutathione metabolism_Homo sapiens_hsa004800.17386726
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.16470220
97Vitamin B6 metabolism_Homo sapiens_hsa007500.16108573
98Steroid biosynthesis_Homo sapiens_hsa001000.15858952
99Malaria_Homo sapiens_hsa051440.15402583
100Tyrosine metabolism_Homo sapiens_hsa003500.14227584

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