ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	proteasome assembly (GO:0043248)	4.69684692
2	DNA deamination (GO:0045006)	4.60652150
3	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	4.53661464
4	regulation of cellular amino acid metabolic process (GO:0006521)	4.40853712
5	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	4.34338919
6	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	4.27596047
7	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	4.27596047
8	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	4.27596047
9	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	4.23992288
10	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	4.23992288
11	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	4.21903580
12	ribosome assembly (GO:0042255)	4.19045258
13	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	4.12026422
14	negative regulation of ligase activity (GO:0051352)	4.12026422
15	signal transduction involved in DNA damage checkpoint (GO:0072422)	4.11702579
16	signal transduction involved in DNA integrity checkpoint (GO:0072401)	4.11702579
17	signal transduction involved in cell cycle checkpoint (GO:0072395)	4.03405744
18	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	4.01435376
19	rRNA modification (GO:0000154)	4.01299689
20	protein deneddylation (GO:0000338)	3.91677482
21	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	3.86383000
22	cullin deneddylation (GO:0010388)	3.83310707
23	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.81931837
24	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	3.58063376
25	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.52897116
26	establishment of integrated proviral latency (GO:0075713)	3.45803550
27	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.45224365
28	establishment of viral latency (GO:0019043)	3.44388544
29	positive regulation of ligase activity (GO:0051351)	3.41777123
30	negative regulation of thymocyte apoptotic process (GO:0070244)	3.40245538
31	AMP metabolic process (GO:0046033)	3.39707819
32	regulation of chronic inflammatory response (GO:0002676)	3.37971693
33	positive regulation of cell cycle arrest (GO:0071158)	3.35513706
34	rRNA methylation (GO:0031167)	3.35112554
35	antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)	3.34862316
36	response to interferon-beta (GO:0035456)	3.34266700
37	ATP synthesis coupled proton transport (GO:0015986)	3.32140255
38	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.32140255
39	pseudouridine synthesis (GO:0001522)	3.26363148
40	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	3.25795812
41	water-soluble vitamin biosynthetic process (GO:0042364)	3.13908359
42	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.13081928
43	maturation of 5.8S rRNA (GO:0000460)	3.12131467
44	positive regulation of defense response to virus by host (GO:0002230)	3.11882475
45	regulation of cellular amine metabolic process (GO:0033238)	3.09384089
46	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.07876211
47	termination of RNA polymerase III transcription (GO:0006386)	3.07274990
48	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.07274990
49	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.04408692
50	adenosine metabolic process (GO:0046085)	3.03034253
51	response to gravity (GO:0009629)	3.02946151
52	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.99724656
53	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.99724656
54	tolerance induction (GO:0002507)	2.96902686
55	negative regulation of protein ubiquitination (GO:0031397)	2.96795777
56	regulation of ubiquitin-protein transferase activity (GO:0051438)	2.94736498
57	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.92261996
58	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.91530354
59	protein complex biogenesis (GO:0070271)	2.89880923
60	regulation of ligase activity (GO:0051340)	2.87997093
61	mitochondrial respiratory chain complex assembly (GO:0033108)	2.83763429
62	regulation of cell cycle arrest (GO:0071156)	2.82476003
63	DNA catabolic process, exonucleolytic (GO:0000738)	2.82215286
64	signal transduction in response to DNA damage (GO:0042770)	2.81117352
65	GTP biosynthetic process (GO:0006183)	2.80917729
66	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.79116689
67	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.79116689
68	NADH dehydrogenase complex assembly (GO:0010257)	2.79116689
69	spliceosomal snRNP assembly (GO:0000387)	2.78124948
70	cytidine deamination (GO:0009972)	2.77955347
71	cytidine metabolic process (GO:0046087)	2.77955347
72	cytidine catabolic process (GO:0006216)	2.77955347
73	negative regulation of protein modification by small protein conjugation or removal (GO:1903321)	2.77089308
74	protein maturation by protein folding (GO:0022417)	2.74341921
75	negative regulation of cell cycle G1/S phase transition (GO:1902807)	2.72048268
76	negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)	2.72048268
77	regulation of isotype switching to IgG isotypes (GO:0048302)	2.70786274
78	regulation of defense response to virus by host (GO:0050691)	2.68140549
79	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	2.67364494
80	sleep (GO:0030431)	2.67160745
81	protein neddylation (GO:0045116)	2.66989553
82	rRNA processing (GO:0006364)	2.66942215
83	organelle disassembly (GO:1903008)	2.66518142
84	regulation of thymocyte apoptotic process (GO:0070243)	2.66305213
85	ribosomal large subunit biogenesis (GO:0042273)	2.64130489
86	rRNA metabolic process (GO:0016072)	2.59933858
87	tRNA metabolic process (GO:0006399)	2.59065508
88	cellular response to interleukin-15 (GO:0071350)	2.58556289
89	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.58294526
90	tRNA aminoacylation for protein translation (GO:0006418)	2.57746800
91	tRNA modification (GO:0006400)	2.57740235
92	amino acid activation (GO:0043038)	2.56790120
93	tRNA aminoacylation (GO:0043039)	2.56790120
94	cellular response to interferon-beta (GO:0035458)	2.56474382
95	tRNA processing (GO:0008033)	2.55255461
96	protein-cofactor linkage (GO:0018065)	2.53277480
97	mitochondrial RNA metabolic process (GO:0000959)	2.52447476
98	ribosome biogenesis (GO:0042254)	2.51057577
99	mannosylation (GO:0097502)	2.50857889
100	regulation of translational termination (GO:0006449)	2.50456380

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.69013906
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.42416564
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.71340847
4	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.68547769
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.33979054
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.12067731
7	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.01398706
8	VDR_23849224_ChIP-Seq_CD4+_Human	2.99909795
9	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.94318531
10	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.73645793
11	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.68002770
12	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.65576707
13	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.60279655
14	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.59457985
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.59391775
16	ELK1_19687146_ChIP-ChIP_HELA_Human	2.46945448
17	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.45013036
18	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.43287212
19	FOXP3_21729870_ChIP-Seq_TREG_Human	2.43281415
20	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.37798102
21	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.26747968
22	E2F7_22180533_ChIP-Seq_HELA_Human	2.23336833
23	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.22394938
24	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.21171321
25	DCP1A_22483619_ChIP-Seq_HELA_Human	2.19567534
26	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.15960660
27	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.14659495
28	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.99666487
29	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.99041617
30	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.98159728
31	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.96801483
32	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.91365333
33	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.89643496
34	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.88608003
35	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.87183651
36	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.84997063
37	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.84843393
38	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.77353618
39	GABP_19822575_ChIP-Seq_HepG2_Human	1.77326822
40	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.76607387
41	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.75686406
42	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.71541753
43	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.71514862
44	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.69715196
45	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.68899650
46	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.68280716
47	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.66805068
48	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.61595270
49	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.60030506
50	XRN2_22483619_ChIP-Seq_HELA_Human	1.58160025
51	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.57853124
52	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.57571849
53	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.56783870
54	TTF2_22483619_ChIP-Seq_HELA_Human	1.55085971
55	MYC_18940864_ChIP-ChIP_HL60_Human	1.54680097
56	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.54037152
57	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.53184351
58	MYB_26560356_Chip-Seq_TH2_Human	1.46336614
59	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.41557120
60	VDR_22108803_ChIP-Seq_LS180_Human	1.40094221
61	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.38903821
62	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.36108102
63	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.31358809
64	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.28516787
65	CIITA_25753668_ChIP-Seq_RAJI_Human	1.26968658
66	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.23920958
67	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.23312969
68	IRF1_19129219_ChIP-ChIP_H3396_Human	1.21196409
69	ZNF274_21170338_ChIP-Seq_K562_Hela	1.19308010
70	GATA3_26560356_Chip-Seq_TH2_Human	1.18883787
71	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.16616063
72	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.15680229
73	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.14698278
74	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.14051932
75	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.13850016
76	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.12275988
77	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.09523165
78	SPI1_23547873_ChIP-Seq_NB4_Human	1.08038823
79	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.05994988
80	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.02996835
81	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.00415857
82	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.99460275
83	KDM5A_27292631_Chip-Seq_BREAST_Human	0.99439711
84	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.99341949
85	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.98301470
86	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.98220038
87	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.94040800
88	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.92506972
89	MYB_26560356_Chip-Seq_TH1_Human	0.89314790
90	ELF5_23300383_ChIP-Seq_T47D_Human	0.85480660
91	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.84992555
92	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.84118419
93	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.82943343
94	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.82697257
95	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.82150889
96	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	0.81945162
97	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.80899894
98	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.80141366
99	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.79251326
100	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.78677532

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000685_abnormal_immune_system	3.54037654
2	MP0001835_abnormal_antigen_presentation	3.45127452
3	MP0003950_abnormal_plasma_membrane	3.19895850
4	MP0005671_abnormal_response_to	3.09638421
5	MP0003436_decreased_susceptibility_to	2.74883567
6	MP0003806_abnormal_nucleotide_metabolis	2.66018443
7	MP0002138_abnormal_hepatobiliary_system	2.64863623
8	MP0002006_tumorigenesis	2.61500620
9	MP0002148_abnormal_hypersensitivity_rea	2.59176664
10	MP0002166_altered_tumor_susceptibility	2.47262436
11	MP0003693_abnormal_embryo_hatching	2.41697652
12	MP0009785_altered_susceptibility_to	2.37071621
13	MP0005000_abnormal_immune_tolerance	2.29506489
14	MP0003786_premature_aging	2.25506442
15	MP0009333_abnormal_splenocyte_physiolog	2.25013693
16	MP0005387_immune_system_phenotype	2.24127387
17	MP0001790_abnormal_immune_system	2.24127387
18	MP0001800_abnormal_humoral_immune	2.13861297
19	MP0004957_abnormal_blastocyst_morpholog	2.13056679
20	MP0001873_stomach_inflammation	2.12185412
21	MP0008058_abnormal_DNA_repair	2.05143043
22	MP0003763_abnormal_thymus_physiology	2.04519129
23	MP0010094_abnormal_chromosome_stability	1.96590021
24	MP0008875_abnormal_xenobiotic_pharmacok	1.95859260
25	MP0004147_increased_porphyrin_level	1.86083249
26	MP0002452_abnormal_antigen_presenting	1.82317729
27	MP0002723_abnormal_immune_serum	1.81110639
28	MP0008007_abnormal_cellular_replicative	1.80883375
29	MP0005084_abnormal_gallbladder_morpholo	1.77938578
30	MP0003718_maternal_effect	1.67842884
31	MP0001819_abnormal_immune_cell	1.65175992
32	MP0002420_abnormal_adaptive_immunity	1.64213805
33	MP0002877_abnormal_melanocyte_morpholog	1.63616404
34	MP0009697_abnormal_copulation	1.56816588
35	MP0009764_decreased_sensitivity_to	1.56647640
36	MP0006072_abnormal_retinal_apoptosis	1.54893619
37	MP0005165_increased_susceptibility_to	1.53767557
38	MP0001853_heart_inflammation	1.50611948
39	MP0008872_abnormal_physiological_respon	1.47734460
40	MP0002876_abnormal_thyroid_physiology	1.40845667
41	MP0003186_abnormal_redox_activity	1.38445990
42	MP0010155_abnormal_intestine_physiology	1.37280497
43	MP0004782_abnormal_surfactant_physiolog	1.36613599
44	MP0002398_abnormal_bone_marrow	1.34283601
45	MP0000689_abnormal_spleen_morphology	1.31113455
46	MP0005360_urolithiasis	1.30428559
47	MP0001845_abnormal_inflammatory_respons	1.29466582
48	MP0001542_abnormal_bone_strength	1.28072679
49	MP0005025_abnormal_response_to	1.28030066
50	MP0001243_abnormal_dermal_layer	1.27676489
51	MP0002722_abnormal_immune_system	1.27600810
52	MP0008775_abnormal_heart_ventricle	1.27160344
53	MP0000716_abnormal_immune_system	1.27093464
54	MP0002019_abnormal_tumor_incidence	1.23023039
55	MP0001881_abnormal_mammary_gland	1.19899669
56	MP0006036_abnormal_mitochondrial_physio	1.18124006
57	MP0005075_abnormal_melanosome_morpholog	1.18020743
58	MP0002429_abnormal_blood_cell	1.17655541
59	MP0001533_abnormal_skeleton_physiology	1.16896854
60	MP0003111_abnormal_nucleus_morphology	1.16585926
61	MP0003077_abnormal_cell_cycle	1.15248088
62	MP0000703_abnormal_thymus_morphology	1.11779281
63	MP0002419_abnormal_innate_immunity	1.11406565
64	MP0003195_calcinosis	1.11150837
65	MP0008469_abnormal_protein_level	1.06806404
66	MP0006035_abnormal_mitochondrial_morpho	1.05853895
67	MP0002405_respiratory_system_inflammati	1.02945515
68	MP0005645_abnormal_hypothalamus_physiol	1.02715711
69	MP0004947_skin_inflammation	1.01034725
70	MP0002163_abnormal_gland_morphology	0.94546581
71	MP0000358_abnormal_cell_content/	0.92782158
72	MP0000490_abnormal_crypts_of	0.92503539
73	MP0003866_abnormal_defecation	0.91432184
74	MP0006054_spinal_hemorrhage	0.88558846
75	MP0002933_joint_inflammation	0.87890943
76	MP0000372_irregular_coat_pigmentation	0.84840202
77	MP0000749_muscle_degeneration	0.84665545
78	MP0002282_abnormal_trachea_morphology	0.83272783
79	MP0005319_abnormal_enzyme/_coenzyme	0.78441151
80	MP0004145_abnormal_muscle_electrophysio	0.78083851
81	MP0001727_abnormal_embryo_implantation	0.77315885
82	MP0008932_abnormal_embryonic_tissue	0.76392273
83	MP0008438_abnormal_cutaneous_collagen	0.75264223
84	MP0002102_abnormal_ear_morphology	0.74389155
85	MP0000647_abnormal_sebaceous_gland	0.72938321
86	MP0003315_abnormal_perineum_morphology	0.71548408
87	MP0004084_abnormal_cardiac_muscle	0.71286733
88	MP0008873_increased_physiological_sensi	0.70484954
89	MP0001348_abnormal_lacrimal_gland	0.69897288
90	MP0008877_abnormal_DNA_methylation	0.69250943
91	MP0000627_abnormal_mammary_gland	0.68663731
92	MP0003045_fibrosis	0.68381970
93	MP0000858_altered_metastatic_potential	0.68270253
94	MP0001919_abnormal_reproductive_system	0.67568102
95	MP0000013_abnormal_adipose_tissue	0.66286502
96	MP0001216_abnormal_epidermal_layer	0.64856788
97	MP0005166_decreased_susceptibility_to	0.63782362
98	MP0002332_abnormal_exercise_endurance	0.63747557
99	MP0002060_abnormal_skin_morphology	0.63539972
100	MP0001501_abnormal_sleep_pattern	0.62132052

Predicted human phenotypes

Rank	Gene Set	Z-score
1	IgG deficiency (HP:0004315)	4.32462635
2	Acute necrotizing encephalopathy (HP:0006965)	3.92622211
3	Elevated erythrocyte sedimentation rate (HP:0003565)	3.85567981
4	Mitochondrial inheritance (HP:0001427)	3.80465572
5	Increased CSF lactate (HP:0002490)	3.77474852
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.65497398
7	Increased serum pyruvate (HP:0003542)	3.62868568
8	Hepatocellular necrosis (HP:0001404)	3.62602837
9	Abnormality of glycolysis (HP:0004366)	3.62415102
10	Acute encephalopathy (HP:0006846)	3.46334722
11	Hepatic necrosis (HP:0002605)	3.38369595
12	Increased serum lactate (HP:0002151)	3.33013906
13	Abnormality of T cell physiology (HP:0011840)	3.29156333
14	Stomatitis (HP:0010280)	3.28083953
15	Increased hepatocellular lipid droplets (HP:0006565)	3.20768971
16	Progressive macrocephaly (HP:0004481)	3.13689161
17	IgM deficiency (HP:0002850)	3.13523392
18	Aplasia/hypoplasia of the uterus (HP:0008684)	3.06132692
19	Hypoplasia of the uterus (HP:0000013)	2.97820153
20	Lipid accumulation in hepatocytes (HP:0006561)	2.96117228
21	Type I transferrin isoform profile (HP:0003642)	2.94459022
22	Delayed CNS myelination (HP:0002188)	2.92967203
23	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.77972324
24	Abnormal protein N-linked glycosylation (HP:0012347)	2.77972324
25	Abnormal protein glycosylation (HP:0012346)	2.77972324
26	Abnormal glycosylation (HP:0012345)	2.77972324
27	Cerebral edema (HP:0002181)	2.73692954
28	Exercise intolerance (HP:0003546)	2.71423840
29	Congenital, generalized hypertrichosis (HP:0004540)	2.71034729
30	Lactic acidosis (HP:0003128)	2.66601102
31	Hypoproteinemia (HP:0003075)	2.62163918
32	IgA deficiency (HP:0002720)	2.59465471
33	Renal cortical cysts (HP:0000803)	2.57809444
34	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.54237353
35	Abnormality of alanine metabolism (HP:0010916)	2.54237353
36	Hyperalaninemia (HP:0003348)	2.54237353
37	Abnormality of T cells (HP:0002843)	2.51895043
38	Rough bone trabeculation (HP:0100670)	2.50992833
39	Abnormality of the anterior horn cell (HP:0006802)	2.49379570
40	Degeneration of anterior horn cells (HP:0002398)	2.49379570
41	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.44134099
42	Entropion (HP:0000621)	2.40989707
43	Prostate neoplasm (HP:0100787)	2.38547569
44	Increased IgM level (HP:0003496)	2.37716502
45	Increased intramyocellular lipid droplets (HP:0012240)	2.36283990
46	Tongue fasciculations (HP:0001308)	2.34636257
47	Renal Fanconi syndrome (HP:0001994)	2.31325538
48	Glucose intolerance (HP:0000833)	2.31088732
49	Reduced antithrombin III activity (HP:0001976)	2.29660293
50	Pancytopenia (HP:0001876)	2.27204327
51	Opisthotonus (HP:0002179)	2.25341051
52	Testicular atrophy (HP:0000029)	2.23751559
53	Respiratory failure (HP:0002878)	2.23195075
54	Reduced subcutaneous adipose tissue (HP:0003758)	2.22932260
55	Type 2 muscle fiber atrophy (HP:0003554)	2.22449019
56	Abnormality of the renal cortex (HP:0011035)	2.22108455
57	Abnormality of B cell number (HP:0010975)	2.21839968
58	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.21787650
59	Cholecystitis (HP:0001082)	2.21315672
60	Abnormal gallbladder physiology (HP:0012438)	2.21315672
61	Abnormality of the pons (HP:0007361)	2.21010067
62	Abnormality of the prostate (HP:0008775)	2.20899421
63	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.18808715
64	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.18808715
65	Exertional dyspnea (HP:0002875)	2.16463158
66	Chronic diarrhea (HP:0002028)	2.15952446
67	Conical tooth (HP:0000698)	2.14177519
68	Autoimmune hemolytic anemia (HP:0001890)	2.14114778
69	Abnormal spermatogenesis (HP:0008669)	2.13953651
70	Optic disc pallor (HP:0000543)	2.12032799
71	Severe combined immunodeficiency (HP:0004430)	2.10131913
72	Methylmalonic aciduria (HP:0012120)	2.09539023
73	Palpitations (HP:0001962)	2.06991596
74	Sparse eyelashes (HP:0000653)	2.06020766
75	Lethargy (HP:0001254)	2.03826597
76	Rhabdomyolysis (HP:0003201)	2.03699202
77	Stomach cancer (HP:0012126)	2.02021419
78	Myoglobinuria (HP:0002913)	2.01301324
79	Pustule (HP:0200039)	2.00813116
80	Muscle fiber atrophy (HP:0100295)	1.99364211
81	Pulmonary infiltrates (HP:0002113)	1.96150313
82	B lymphocytopenia (HP:0010976)	1.94041760
83	Ureteral duplication (HP:0000073)	1.93143346
84	Eosinophilia (HP:0001880)	1.92018865
85	Increased muscle lipid content (HP:0009058)	1.91484431
86	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.90737150
87	Muscle fibrillation (HP:0010546)	1.89323516
88	Neutropenia (HP:0001875)	1.87722496
89	Methylmalonic acidemia (HP:0002912)	1.87373365
90	Duplicated collecting system (HP:0000081)	1.84137095
91	Hypoplasia of the pons (HP:0012110)	1.80412512
92	Microvesicular hepatic steatosis (HP:0001414)	1.79855871
93	Granulocytopenia (HP:0001913)	1.79577967
94	Constricted visual fields (HP:0001133)	1.76508206
95	Abnormality of methionine metabolism (HP:0010901)	1.75194083
96	Abnormal trabecular bone morphology (HP:0100671)	1.73329561
97	Dicarboxylic aciduria (HP:0003215)	1.72530162
98	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.72530162
99	Generalized aminoaciduria (HP:0002909)	1.71001045
100	Myositis (HP:0100614)	1.67161719

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	5.01028511
2	BUB1	3.33244982
3	ZAK	3.12316936
4	VRK1	3.01015855
5	TLK1	3.00660060
6	TESK2	2.65122748
7	EIF2AK3	2.52073211
8	TSSK6	2.47048783
9	TXK	2.30655172
10	MST4	2.22393808
11	NUAK1	2.16390180
12	EIF2AK1	2.10325458
13	TAOK3	2.02033954
14	NEK1	1.87656419
15	MAP4K2	1.79109392
16	SRPK1	1.76681512
17	DAPK1	1.76434913
18	TAF1	1.76434856
19	BCKDK	1.73897149
20	TESK1	1.72817579
21	PBK	1.66975399
22	EIF2AK2	1.62913498
23	NME2	1.59494938
24	MAP3K14	1.59395195
25	CDK8	1.55722793
26	PLK3	1.47082986
27	MAPKAPK3	1.45924016
28	SCYL2	1.40521031
29	STK16	1.38267611
30	WNK4	1.37819671
31	LIMK1	1.28326690
32	IKBKB	1.27052548
33	EPHA2	1.15041956
34	KDR	1.13761643
35	NME1	1.12859818
36	TRIM28	1.12748320
37	BMPR1B	1.08417694
38	TBK1	1.04407642
39	MAP3K12	1.03148949
40	STK10	1.02293409
41	ADRBK2	0.99598525
42	TEC	0.99064886
43	MAPKAPK5	0.98421703
44	CCNB1	0.97955907
45	PHKG1	0.95994137
46	PHKG2	0.95994137
47	MAP2K2	0.95524424
48	CAMKK2	0.93807355
49	KIT	0.87472718
50	MYLK	0.86046471
51	IKBKE	0.85799583
52	MAP4K1	0.85407315
53	PIM2	0.84174029
54	ITK	0.84001636
55	RPS6KA5	0.83182950
56	FLT3	0.83076159
57	DAPK3	0.79216505
58	ARAF	0.76891678
59	PAK4	0.76519603
60	MUSK	0.74520906
61	CSNK1G3	0.73806858
62	MOS	0.72892702
63	PLK2	0.72592571
64	GRK6	0.71962868
65	STK39	0.71536213
66	AURKA	0.68726195
67	PDK2	0.67399304
68	GRK1	0.66592980
69	CSNK1A1L	0.66088464
70	IRAK3	0.65059323
71	AURKB	0.64894763
72	TGFBR1	0.64503025
73	PRKCI	0.63689061
74	MAP2K6	0.61862710
75	PLK4	0.61328248
76	LMTK2	0.61117786
77	GRK5	0.60684789
78	ILK	0.55722362
79	SMG1	0.52905044
80	SYK	0.52344606
81	OXSR1	0.51904092
82	CSNK1G1	0.50782839
83	CDK7	0.48936368
84	PIK3CG	0.47645332
85	STK4	0.44727021
86	MKNK1	0.42829702
87	CSNK1G2	0.42747535
88	TTK	0.41930780
89	PTK2B	0.41163109
90	CHUK	0.40225505
91	BRSK2	0.40080633
92	PLK1	0.39845449
93	SIK3	0.39806196
94	JAK3	0.38839111
95	CDK9	0.38501809
96	CSF1R	0.37033547
97	CDC7	0.35789272
98	ADRBK1	0.35405633
99	ERBB4	0.33419825
100	GRK7	0.32448163

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	5.74898790
2	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.89599322
3	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.57445640
4	Allograft rejection_Homo sapiens_hsa05330	2.47602330
5	Asthma_Homo sapiens_hsa05310	2.46716226
6	RNA polymerase_Homo sapiens_hsa03020	2.31222780
7	Protein export_Homo sapiens_hsa03060	2.24142168
8	DNA replication_Homo sapiens_hsa03030	2.21518314
9	Oxidative phosphorylation_Homo sapiens_hsa00190	2.20667582
10	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.14349211
11	Graft-versus-host disease_Homo sapiens_hsa05332	2.07866831
12	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.02147860
13	Primary immunodeficiency_Homo sapiens_hsa05340	1.99193333
14	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.91596828
15	Parkinsons disease_Homo sapiens_hsa05012	1.90454473
16	Ribosome_Homo sapiens_hsa03010	1.89467030
17	Mismatch repair_Homo sapiens_hsa03430	1.87882396
18	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.83582231
19	Pyrimidine metabolism_Homo sapiens_hsa00240	1.75537809
20	Antigen processing and presentation_Homo sapiens_hsa04612	1.74435524
21	Type I diabetes mellitus_Homo sapiens_hsa04940	1.73217539
22	RNA degradation_Homo sapiens_hsa03018	1.70742296
23	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.70549758
24	One carbon pool by folate_Homo sapiens_hsa00670	1.64013375
25	Base excision repair_Homo sapiens_hsa03410	1.63454667
26	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.55174736
27	Spliceosome_Homo sapiens_hsa03040	1.53802980
28	Nucleotide excision repair_Homo sapiens_hsa03420	1.50855489
29	Homologous recombination_Homo sapiens_hsa03440	1.49652841
30	Non-homologous end-joining_Homo sapiens_hsa03450	1.41470826
31	RNA transport_Homo sapiens_hsa03013	1.34323581
32	Sulfur metabolism_Homo sapiens_hsa00920	1.33003065
33	Basal transcription factors_Homo sapiens_hsa03022	1.30331138
34	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.27511894
35	Purine metabolism_Homo sapiens_hsa00230	1.24496802
36	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.21369635
37	Huntingtons disease_Homo sapiens_hsa05016	1.19360319
38	Alzheimers disease_Homo sapiens_hsa05010	1.17169638
39	Viral myocarditis_Homo sapiens_hsa05416	1.15822620
40	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.11199054
41	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.10924907
42	Propanoate metabolism_Homo sapiens_hsa00640	1.10656634
43	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.00560079
44	Fatty acid elongation_Homo sapiens_hsa00062	1.00282829
45	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.98286544
46	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.95592898
47	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.94604035
48	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.92963953
49	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.92098434
50	Pyruvate metabolism_Homo sapiens_hsa00620	0.90390540
51	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.89494189
52	Pentose phosphate pathway_Homo sapiens_hsa00030	0.88948509
53	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.88941183
54	Rheumatoid arthritis_Homo sapiens_hsa05323	0.88745268
55	Nitrogen metabolism_Homo sapiens_hsa00910	0.88706496
56	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.88182519
57	Carbon metabolism_Homo sapiens_hsa01200	0.87262298
58	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.86591978
59	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.77304370
60	Selenocompound metabolism_Homo sapiens_hsa00450	0.75152390
61	Herpes simplex infection_Homo sapiens_hsa05168	0.74403246
62	Folate biosynthesis_Homo sapiens_hsa00790	0.73084904
63	Peroxisome_Homo sapiens_hsa04146	0.70507158
64	Alcoholism_Homo sapiens_hsa05034	0.67246122
65	p53 signaling pathway_Homo sapiens_hsa04115	0.65117118
66	Glutathione metabolism_Homo sapiens_hsa00480	0.64499948
67	Sulfur relay system_Homo sapiens_hsa04122	0.63531407
68	Viral carcinogenesis_Homo sapiens_hsa05203	0.63286686
69	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.63091045
70	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.62949061
71	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.62325482
72	Fanconi anemia pathway_Homo sapiens_hsa03460	0.61758477
73	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.60389517
74	Legionellosis_Homo sapiens_hsa05134	0.59093061
75	Measles_Homo sapiens_hsa05162	0.56447686
76	Regulation of autophagy_Homo sapiens_hsa04140	0.54630551
77	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.53824593
78	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.53026642
79	Shigellosis_Homo sapiens_hsa05131	0.51013894
80	Metabolic pathways_Homo sapiens_hsa01100	0.50948444
81	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.44462007
82	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.43593422
83	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.43494628
84	Leishmaniasis_Homo sapiens_hsa05140	0.40598887
85	Caffeine metabolism_Homo sapiens_hsa00232	0.38690674
86	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.37566967
87	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.36494012
88	Apoptosis_Homo sapiens_hsa04210	0.35832204
89	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.35330686
90	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.34075063
91	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.30267799
92	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.29062942
93	Galactose metabolism_Homo sapiens_hsa00052	0.28725272
94	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.27668757
95	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.27554261
96	Linoleic acid metabolism_Homo sapiens_hsa00591	0.26971341
97	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.26261193
98	Tryptophan metabolism_Homo sapiens_hsa00380	0.26109153
99	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.26052009
100	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.25840772

LDHAP7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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