ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	6.00522704
2	L-fucose catabolic process (GO:0042355)	4.81959373
3	fucose catabolic process (GO:0019317)	4.81959373
4	L-fucose metabolic process (GO:0042354)	4.81959373
5	DNA deamination (GO:0045006)	4.27420517
6	kynurenine metabolic process (GO:0070189)	4.11191589
7	piRNA metabolic process (GO:0034587)	4.06586959
8	negative regulation of telomere maintenance (GO:0032205)	3.97380645
9	platelet dense granule organization (GO:0060155)	3.95980501
10	water-soluble vitamin biosynthetic process (GO:0042364)	3.93516166
11	indolalkylamine metabolic process (GO:0006586)	3.80679095
12	indole-containing compound catabolic process (GO:0042436)	3.78274649
13	indolalkylamine catabolic process (GO:0046218)	3.78274649
14	tryptophan catabolic process (GO:0006569)	3.78274649
15	regulation of memory T cell differentiation (GO:0043380)	3.74495498
16	preassembly of GPI anchor in ER membrane (GO:0016254)	3.67491299
17	positive regulation of defense response to virus by host (GO:0002230)	3.58676195
18	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.56658453
19	tryptophan metabolic process (GO:0006568)	3.47805275
20	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.41788610
21	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.41788610
22	ubiquinone biosynthetic process (GO:0006744)	3.32380119
23	DNA methylation involved in gamete generation (GO:0043046)	3.27661555
24	protein-cofactor linkage (GO:0018065)	3.24589589
25	protein polyglutamylation (GO:0018095)	3.11361616
26	respiratory chain complex IV assembly (GO:0008535)	3.10778817
27	adaptation of signaling pathway (GO:0023058)	3.10733904
28	positive regulation of fatty acid transport (GO:2000193)	3.08155705
29	multicellular organism reproduction (GO:0032504)	3.07486544
30	primary amino compound metabolic process (GO:1901160)	3.06211773
31	ubiquinone metabolic process (GO:0006743)	3.04497430
32	indole-containing compound metabolic process (GO:0042430)	3.01863052
33	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.01857243
34	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.00615070
35	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.00301416
36	regulation of mitotic spindle checkpoint (GO:1903504)	3.00301416
37	positive regulation of prostaglandin secretion (GO:0032308)	2.99769107
38	magnesium ion transport (GO:0015693)	2.93649792
39	response to pheromone (GO:0019236)	2.93114097
40	organic cation transport (GO:0015695)	2.92952981
41	sulfation (GO:0051923)	2.92574216
42	positive regulation of T-helper 1 type immune response (GO:0002827)	2.91891210
43	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.90912123
44	cellular ketone body metabolic process (GO:0046950)	2.85133347
45	detection of light stimulus involved in visual perception (GO:0050908)	2.82659160
46	detection of light stimulus involved in sensory perception (GO:0050962)	2.82659160
47	mitotic cell cycle arrest (GO:0071850)	2.81924380
48	regulation of cilium movement (GO:0003352)	2.78022459
49	male meiosis I (GO:0007141)	2.77507412
50	negative regulation of mast cell activation (GO:0033004)	2.76598343
51	synaptic transmission, cholinergic (GO:0007271)	2.75565744
52	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.74006112
53	mannosylation (GO:0097502)	2.73344740
54	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.73273047
55	nephron epithelium morphogenesis (GO:0072088)	2.70442271
56	nephron tubule morphogenesis (GO:0072078)	2.70442271
57	positive regulation of icosanoid secretion (GO:0032305)	2.68675409
58	amine catabolic process (GO:0009310)	2.67934708
59	cellular biogenic amine catabolic process (GO:0042402)	2.67934708
60	pseudouridine synthesis (GO:0001522)	2.67393372
61	regulation of action potential (GO:0098900)	2.67001678
62	quinone biosynthetic process (GO:1901663)	2.66823973
63	axoneme assembly (GO:0035082)	2.65868183
64	behavioral response to ethanol (GO:0048149)	2.65216105
65	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.64095753
66	adenosine metabolic process (GO:0046085)	2.64069198
67	dopamine transport (GO:0015872)	2.63846446
68	valine metabolic process (GO:0006573)	2.63310750
69	epithelial cilium movement (GO:0003351)	2.59878603
70	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.59290648
71	serotonin metabolic process (GO:0042428)	2.58447487
72	auditory receptor cell stereocilium organization (GO:0060088)	2.57733986
73	ketone body metabolic process (GO:1902224)	2.57213195
74	basic amino acid transport (GO:0015802)	2.55560330
75	reflex (GO:0060004)	2.55253292
76	negative regulation of interleukin-1 production (GO:0032692)	2.54018834
77	GPI anchor metabolic process (GO:0006505)	2.52542440
78	kidney morphogenesis (GO:0060993)	2.52173157
79	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.51855502
80	tRNA processing (GO:0008033)	2.51121572
81	cellular response to ATP (GO:0071318)	2.51112341
82	gamma-aminobutyric acid transport (GO:0015812)	2.50731816
83	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	2.50464213
84	cytochrome complex assembly (GO:0017004)	2.50164980
85	regulation of defense response to virus by host (GO:0050691)	2.50045503
86	metallo-sulfur cluster assembly (GO:0031163)	2.49819944
87	iron-sulfur cluster assembly (GO:0016226)	2.49819944
88	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.49170784
89	protein complex biogenesis (GO:0070271)	2.48180323
90	L-methionine salvage (GO:0071267)	2.48119630
91	L-methionine biosynthetic process (GO:0071265)	2.48119630
92	amino acid salvage (GO:0043102)	2.48119630
93	S-adenosylmethionine metabolic process (GO:0046500)	2.47849471
94	male meiosis (GO:0007140)	2.46835117
95	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.46718486
96	tRNA modification (GO:0006400)	2.46700180
97	nucleotide transmembrane transport (GO:1901679)	2.46312930
98	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.46227434
99	rhodopsin mediated signaling pathway (GO:0016056)	2.46101028
100	alanine transport (GO:0032328)	2.45684281

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.42598631
2	VDR_22108803_ChIP-Seq_LS180_Human	3.84941187
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.17467951
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.78821947
5	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.50772319
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.41496265
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.40015430
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.33988191
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.14419033
10	EZH2_22144423_ChIP-Seq_EOC_Human	2.03554503
11	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.99292056
12	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.95857798
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.95242347
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.94060654
15	TP53_22573176_ChIP-Seq_HFKS_Human	1.89321872
16	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.88676206
17	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.87263485
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.81444375
19	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.80487277
20	P300_19829295_ChIP-Seq_ESCs_Human	1.80176850
21	IRF1_19129219_ChIP-ChIP_H3396_Human	1.79747288
22	EWS_26573619_Chip-Seq_HEK293_Human	1.79196834
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.78845849
24	FUS_26573619_Chip-Seq_HEK293_Human	1.77929787
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.77747244
26	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.62261287
27	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.60192352
28	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.60192352
29	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.58188570
30	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.57760108
31	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.56776435
32	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.52463205
33	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.51752368
34	SOX2_19829295_ChIP-Seq_ESCs_Human	1.51114356
35	NANOG_19829295_ChIP-Seq_ESCs_Human	1.51114356
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.47608145
37	TAF15_26573619_Chip-Seq_HEK293_Human	1.47452231
38	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.47022750
39	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.46169774
40	VDR_23849224_ChIP-Seq_CD4+_Human	1.46153765
41	HOXB7_26014856_ChIP-Seq_BT474_Human	1.44101270
42	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.42115981
43	MYC_18940864_ChIP-ChIP_HL60_Human	1.39882354
44	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.37457103
45	BCAT_22108803_ChIP-Seq_LS180_Human	1.36269673
46	REST_21632747_ChIP-Seq_MESCs_Mouse	1.35607726
47	NCOR_22424771_ChIP-Seq_293T_Human	1.35315330
48	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.32889483
49	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.31971062
50	CBP_20019798_ChIP-Seq_JUKART_Human	1.30329898
51	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.30329898
52	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.29417089
53	AR_20517297_ChIP-Seq_VCAP_Human	1.29237767
54	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.27797017
55	STAT3_23295773_ChIP-Seq_U87_Human	1.26763064
56	TCF4_23295773_ChIP-Seq_U87_Human	1.26199523
57	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.25051152
58	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.24759852
59	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.22795814
60	AR_25329375_ChIP-Seq_VCAP_Human	1.22542227
61	TCF4_22108803_ChIP-Seq_LS180_Human	1.21520405
62	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.21440614
63	ERA_21632823_ChIP-Seq_H3396_Human	1.20346973
64	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.20262603
65	MYC_19829295_ChIP-Seq_ESCs_Human	1.20165637
66	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.19748387
67	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.18870546
68	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.18796032
69	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.18048598
70	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.17987145
71	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.17318942
72	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.16118921
73	GATA3_26560356_Chip-Seq_TH2_Human	1.15378948
74	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.13261504
75	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.13021601
76	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.12706397
77	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.12687178
78	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.12031665
79	RUNX2_22187159_ChIP-Seq_PCA_Human	1.11814694
80	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.11367769
81	NANOG_20526341_ChIP-Seq_ESCs_Human	1.11196571
82	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.10912633
83	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.09874728
84	SMAD4_21799915_ChIP-Seq_A2780_Human	1.08759069
85	OCT4_20526341_ChIP-Seq_ESCs_Human	1.07479937
86	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.07446963
87	TAF2_19829295_ChIP-Seq_ESCs_Human	1.06073150
88	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.05956172
89	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.05661774
90	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.04990943
91	CDX2_22108803_ChIP-Seq_LS180_Human	1.04804707
92	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.04263005
93	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.02851013
94	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.02657354
95	P53_21459846_ChIP-Seq_SAOS-2_Human	1.02457943
96	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.00466278
97	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.00228666
98	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.00065664
99	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.99750499
100	ELK1_19687146_ChIP-ChIP_HELA_Human	0.96157860

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.49113796
2	MP0002102_abnormal_ear_morphology	3.18865104
3	MP0008877_abnormal_DNA_methylation	3.14077200
4	MP0001986_abnormal_taste_sensitivity	3.08815873
5	MP0002837_dystrophic_cardiac_calcinosis	2.65814467
6	MP0008875_abnormal_xenobiotic_pharmacok	2.61554135
7	MP0001968_abnormal_touch/_nociception	2.55149827
8	MP0004147_increased_porphyrin_level	2.47052385
9	MP0006292_abnormal_olfactory_placode	2.45938086
10	MP0005551_abnormal_eye_electrophysiolog	2.38396742
11	MP0008872_abnormal_physiological_respon	2.20511716
12	MP0005646_abnormal_pituitary_gland	2.19877765
13	MP0004885_abnormal_endolymph	2.17012762
14	MP0002138_abnormal_hepatobiliary_system	2.13801790
15	MP0002876_abnormal_thyroid_physiology	2.12482381
16	MP0002736_abnormal_nociception_after	2.05016442
17	MP0006072_abnormal_retinal_apoptosis	2.04962770
18	MP0003011_delayed_dark_adaptation	1.98621968
19	MP0003646_muscle_fatigue	1.89868902
20	MP0009046_muscle_twitch	1.85931005
21	MP0009745_abnormal_behavioral_response	1.83459763
22	MP0004043_abnormal_pH_regulation	1.81386453
23	MP0002638_abnormal_pupillary_reflex	1.66966691
24	MP0002272_abnormal_nervous_system	1.65762348
25	MP0005253_abnormal_eye_physiology	1.62663246
26	MP0000372_irregular_coat_pigmentation	1.62079833
27	MP0003787_abnormal_imprinting	1.59606078
28	MP0001501_abnormal_sleep_pattern	1.59261340
29	MP0000427_abnormal_hair_cycle	1.58600540
30	MP0005075_abnormal_melanosome_morpholog	1.55345585
31	MP0005645_abnormal_hypothalamus_physiol	1.52043859
32	MP0002938_white_spotting	1.47181558
33	MP0005389_reproductive_system_phenotype	1.47022228
34	MP0006276_abnormal_autonomic_nervous	1.44865035
35	MP0001984_abnormal_olfaction	1.42197669
36	MP0003283_abnormal_digestive_organ	1.40777389
37	MP0004133_heterotaxia	1.39602022
38	MP0004142_abnormal_muscle_tone	1.37496969
39	MP0005084_abnormal_gallbladder_morpholo	1.34585073
40	MP0002095_abnormal_skin_pigmentation	1.34337431
41	MP0002160_abnormal_reproductive_system	1.34146208
42	MP0010386_abnormal_urinary_bladder	1.32791521
43	MP0003724_increased_susceptibility_to	1.31068828
44	MP0002735_abnormal_chemical_nociception	1.29461165
45	MP0001486_abnormal_startle_reflex	1.27442593
46	MP0000569_abnormal_digit_pigmentation	1.27117121
47	MP0001485_abnormal_pinna_reflex	1.25329594
48	MP0005174_abnormal_tail_pigmentation	1.25036046
49	MP0008775_abnormal_heart_ventricle	1.24245077
50	MP0005671_abnormal_response_to	1.23448344
51	MP0002234_abnormal_pharynx_morphology	1.22377794
52	MP0001502_abnormal_circadian_rhythm	1.21745470
53	MP0002572_abnormal_emotion/affect_behav	1.18964522
54	MP0001919_abnormal_reproductive_system	1.18490213
55	MP0000685_abnormal_immune_system	1.17389307
56	MP0002733_abnormal_thermal_nociception	1.15415727
57	MP0002064_seizures	1.11645715
58	MP0001905_abnormal_dopamine_level	1.10378213
59	MP0002254_reproductive_system_inflammat	1.08565470
60	MP0003880_abnormal_central_pattern	1.06851243
61	MP0001970_abnormal_pain_threshold	1.05873457
62	MP0004742_abnormal_vestibular_system	1.05092345
63	MP0002928_abnormal_bile_duct	1.05055737
64	MP0002277_abnormal_respiratory_mucosa	1.01247571
65	MP0005332_abnormal_amino_acid	1.00805375
66	MP0005167_abnormal_blood-brain_barrier	1.00431003
67	MP0000383_abnormal_hair_follicle	1.00177957
68	MP0000631_abnormal_neuroendocrine_gland	0.98018782
69	MP0005410_abnormal_fertilization	0.97650292
70	MP0004215_abnormal_myocardial_fiber	0.96345712
71	MP0002557_abnormal_social/conspecific_i	0.96282703
72	MP0000230_abnormal_systemic_arterial	0.95605572
73	MP0003878_abnormal_ear_physiology	0.94369373
74	MP0005377_hearing/vestibular/ear_phenot	0.94369373
75	MP0005636_abnormal_mineral_homeostasis	0.93009240
76	MP0004145_abnormal_muscle_electrophysio	0.92543958
77	MP0002693_abnormal_pancreas_physiology	0.90751359
78	MP0002653_abnormal_ependyma_morphology	0.87795665
79	MP0009764_decreased_sensitivity_to	0.86292480
80	MP0003252_abnormal_bile_duct	0.86131420
81	MP0001765_abnormal_ion_homeostasis	0.84114875
82	MP0002063_abnormal_learning/memory/cond	0.83873097
83	MP0004130_abnormal_muscle_cell	0.81658350
84	MP0005195_abnormal_posterior_eye	0.81408847
85	MP0005085_abnormal_gallbladder_physiolo	0.81330907
86	MP0009785_altered_susceptibility_to	0.81249282
87	MP0002067_abnormal_sensory_capabilities	0.81052261
88	MP0000538_abnormal_urinary_bladder	0.80644325
89	MP0008789_abnormal_olfactory_epithelium	0.80010799
90	MP0010329_abnormal_lipoprotein_level	0.79581094
91	MP0002148_abnormal_hypersensitivity_rea	0.78114766
92	MP0000647_abnormal_sebaceous_gland	0.77272520
93	MP0002229_neurodegeneration	0.76868342
94	MP0001764_abnormal_homeostasis	0.76817529
95	MP0001293_anophthalmia	0.72880750
96	MP0001529_abnormal_vocalization	0.72780313
97	MP0005387_immune_system_phenotype	0.72265557
98	MP0001790_abnormal_immune_system	0.72265557
99	MP0003119_abnormal_digestive_system	0.72104252
100	MP0003786_premature_aging	0.70858565

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.37501497
2	Congenital stationary night blindness (HP:0007642)	4.37337272
3	Molar tooth sign on MRI (HP:0002419)	3.96189189
4	Abnormality of midbrain morphology (HP:0002418)	3.96189189
5	Pancreatic fibrosis (HP:0100732)	3.66958663
6	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.65739084
7	Abnormality of alanine metabolism (HP:0010916)	3.65739084
8	Hyperalaninemia (HP:0003348)	3.65739084
9	True hermaphroditism (HP:0010459)	3.43584033
10	Type II lissencephaly (HP:0007260)	3.35349645
11	Abnormal drinking behavior (HP:0030082)	3.31644702
12	Polydipsia (HP:0001959)	3.31644702
13	Nephronophthisis (HP:0000090)	3.15949570
14	Abnormality of the renal cortex (HP:0011035)	3.15255502
15	Abolished electroretinogram (ERG) (HP:0000550)	2.95401611
16	Bile duct proliferation (HP:0001408)	2.88722845
17	Abnormal biliary tract physiology (HP:0012439)	2.88722845
18	Tubular atrophy (HP:0000092)	2.86934957
19	Medial flaring of the eyebrow (HP:0010747)	2.82610744
20	Hypomagnesemia (HP:0002917)	2.82119028
21	Attenuation of retinal blood vessels (HP:0007843)	2.80289782
22	Stomatitis (HP:0010280)	2.79552701
23	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.78199928
24	Abnormality of the renal medulla (HP:0100957)	2.75683144
25	Congenital, generalized hypertrichosis (HP:0004540)	2.69810257
26	Progressive inability to walk (HP:0002505)	2.69509131
27	Pendular nystagmus (HP:0012043)	2.68129492
28	Methylmalonic acidemia (HP:0002912)	2.62022406
29	Hypothermia (HP:0002045)	2.58824975
30	Inability to walk (HP:0002540)	2.58479764
31	Polyuria (HP:0000103)	2.56988745
32	Large for gestational age (HP:0001520)	2.53797262
33	Cystic liver disease (HP:0006706)	2.44859507
34	Chronic hepatic failure (HP:0100626)	2.43488864
35	Congenital sensorineural hearing impairment (HP:0008527)	2.40225195
36	Abnormal rod and cone electroretinograms (HP:0008323)	2.34317313
37	Aplasia/hypoplasia of the uterus (HP:0008684)	2.29847883
38	Gait imbalance (HP:0002141)	2.25193480
39	Increased corneal curvature (HP:0100692)	2.24719460
40	Keratoconus (HP:0000563)	2.24719460
41	IgG deficiency (HP:0004315)	2.23718767
42	Lipid accumulation in hepatocytes (HP:0006561)	2.23668051
43	Congenital primary aphakia (HP:0007707)	2.20738668
44	Decreased circulating renin level (HP:0003351)	2.18723660
45	Methylmalonic aciduria (HP:0012120)	2.18660045
46	Tetany (HP:0001281)	2.17876210
47	Nephrogenic diabetes insipidus (HP:0009806)	2.16919016
48	Renal cortical cysts (HP:0000803)	2.16094419
49	Lissencephaly (HP:0001339)	2.14269665
50	Thyroid-stimulating hormone excess (HP:0002925)	2.13607340
51	Chorioretinal atrophy (HP:0000533)	2.11320094
52	Abnormal urine output (HP:0012590)	2.09799225
53	Cerebellar dysplasia (HP:0007033)	2.08033301
54	Delayed CNS myelination (HP:0002188)	2.06509196
55	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.03368322
56	Abnormality of magnesium homeostasis (HP:0004921)	2.00792974
57	Furrowed tongue (HP:0000221)	1.99051460
58	Ketosis (HP:0001946)	1.98859878
59	Congenital hepatic fibrosis (HP:0002612)	1.96715822
60	Sclerocornea (HP:0000647)	1.96677546
61	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.96576070
62	Hyperglycinemia (HP:0002154)	1.95625431
63	Constricted visual fields (HP:0001133)	1.95008146
64	Broad-based gait (HP:0002136)	1.93162720
65	Hypoplasia of the uterus (HP:0000013)	1.91105100
66	Severe muscular hypotonia (HP:0006829)	1.89913994
67	Gaze-evoked nystagmus (HP:0000640)	1.89666260
68	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.88648467
69	Duplicated collecting system (HP:0000081)	1.85783001
70	Abnormality of the ileum (HP:0001549)	1.84827738
71	Stomach cancer (HP:0012126)	1.84637661
72	Absent/shortened dynein arms (HP:0200106)	1.83252184
73	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.83252184
74	Patellar aplasia (HP:0006443)	1.83146498
75	Abnormality of the renal collecting system (HP:0004742)	1.82795559
76	Abnormality of renal excretion (HP:0011036)	1.82046871
77	Anencephaly (HP:0002323)	1.82027915
78	Abnormality of the pons (HP:0007361)	1.81988118
79	Absent thumb (HP:0009777)	1.81525448
80	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.80444387
81	Hyperventilation (HP:0002883)	1.80296455
82	Fair hair (HP:0002286)	1.80143173
83	Aplasia/Hypoplasia of the patella (HP:0006498)	1.78889918
84	Short tibia (HP:0005736)	1.78452562
85	Clubbing of toes (HP:0100760)	1.76510830
86	Hypoplasia of the pons (HP:0012110)	1.75541317
87	Clumsiness (HP:0002312)	1.74840253
88	Vaginal atresia (HP:0000148)	1.74077391
89	Genital tract atresia (HP:0001827)	1.73737228
90	Mesangial abnormality (HP:0001966)	1.73299938
91	Asplenia (HP:0001746)	1.72642167
92	Abnormality of serum amino acid levels (HP:0003112)	1.71836628
93	Ketoacidosis (HP:0001993)	1.71479993
94	Abnormality of glycine metabolism (HP:0010895)	1.70838159
95	Abnormality of serine family amino acid metabolism (HP:0010894)	1.70838159
96	Meckel diverticulum (HP:0002245)	1.70617759
97	Increased hepatocellular lipid droplets (HP:0006565)	1.70585753
98	Mitochondrial inheritance (HP:0001427)	1.70253607
99	Retinal dysplasia (HP:0007973)	1.69632205
100	Postaxial foot polydactyly (HP:0001830)	1.68532895

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.41419050
2	TAOK3	3.92595974
3	ADRBK2	3.88413840
4	MAP4K2	3.18613230
5	ZAK	3.12855369
6	ACVR1B	2.92938567
7	TXK	2.84235809
8	WNK4	2.77868428
9	TLK1	2.76604143
10	NUAK1	2.73402349
11	GRK1	2.59125282
12	WNK3	2.35272740
13	PINK1	2.17329802
14	BMPR1B	2.16963186
15	INSRR	1.75389514
16	DAPK2	1.46999202
17	MAPK13	1.45055508
18	OXSR1	1.41330030
19	ADRBK1	1.40411040
20	MAP2K2	1.34222457
21	BCKDK	1.27298945
22	STK39	1.19394350
23	MST4	1.15847113
24	MAP2K6	1.15315382
25	IKBKB	1.13460501
26	TIE1	1.12061379
27	PHKG2	1.05598934
28	PHKG1	1.05598934
29	NME1	1.02322741
30	CSNK1G3	1.01108058
31	NEK2	0.99969745
32	MKNK2	0.98526498
33	PLK4	0.96850753
34	MAP3K4	0.94484863
35	MAPKAPK3	0.94213905
36	CSNK1G1	0.93232678
37	DYRK2	0.92381997
38	PLK2	0.91556870
39	VRK1	0.90491395
40	CSNK1G2	0.90229597
41	KIT	0.89515405
42	PRKCE	0.89127274
43	MAPK15	0.88580915
44	GRK7	0.85176830
45	IKBKE	0.84904334
46	PRKCG	0.84492712
47	STK38L	0.79811585
48	SIK2	0.78951411
49	PAK3	0.76833520
50	TRIM28	0.76110088
51	EIF2AK3	0.75929142
52	PRKCI	0.75718180
53	PIK3CA	0.74867493
54	CSNK1A1L	0.74623911
55	PLK3	0.71783921
56	TSSK6	0.71336479
57	CHUK	0.70930683
58	MAP2K1	0.67926974
59	EIF2AK2	0.64233788
60	TGFBR1	0.62962831
61	RPS6KA5	0.57056461
62	MAP2K7	0.56264606
63	GRK5	0.56102010
64	PRKCQ	0.55882283
65	TEC	0.55061675
66	MUSK	0.54777206
67	ERBB3	0.51725979
68	BRSK2	0.50969178
69	ITK	0.50490904
70	NLK	0.49463864
71	WNK1	0.47800460
72	JAK3	0.47549016
73	PTK2B	0.47102929
74	MAPKAPK5	0.46536176
75	STK11	0.45814603
76	CAMKK2	0.45456579
77	FGFR2	0.45330619
78	GRK6	0.44899460
79	MAP3K14	0.44008018
80	MKNK1	0.43756350
81	CAMK2A	0.42966452
82	CSNK1A1	0.42479015
83	SYK	0.41809520
84	FLT3	0.41167171
85	NTRK3	0.41139198
86	NTRK2	0.41054631
87	IRAK1	0.40687537
88	STK16	0.40253511
89	PRKACA	0.39967939
90	CASK	0.39743372
91	VRK2	0.39467825
92	MAP4K1	0.38893214
93	STK3	0.36566792
94	PRKCA	0.35654880
95	PLK1	0.35318999
96	CSNK1D	0.34862443
97	TBK1	0.34358053
98	ABL1	0.33701249
99	PRKCZ	0.32450225
100	TRPM7	0.29091146

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nitrogen metabolism_Homo sapiens_hsa00910	3.01401679
2	Selenocompound metabolism_Homo sapiens_hsa00450	2.78524539
3	Phototransduction_Homo sapiens_hsa04744	2.67465557
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.53048423
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.49437018
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.47457687
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.38024698
8	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.30321927
9	One carbon pool by folate_Homo sapiens_hsa00670	2.24426440
10	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.20228358
11	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.17587677
12	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.86058399
13	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.83604145
14	Tryptophan metabolism_Homo sapiens_hsa00380	1.79691994
15	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.74528230
16	Butanoate metabolism_Homo sapiens_hsa00650	1.72411863
17	Ether lipid metabolism_Homo sapiens_hsa00565	1.71753799
18	Nicotine addiction_Homo sapiens_hsa05033	1.69990913
19	RNA polymerase_Homo sapiens_hsa03020	1.69333588
20	Caffeine metabolism_Homo sapiens_hsa00232	1.65657250
21	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.62605276
22	Oxidative phosphorylation_Homo sapiens_hsa00190	1.59963076
23	Sulfur metabolism_Homo sapiens_hsa00920	1.55523444
24	Protein export_Homo sapiens_hsa03060	1.53027414
25	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.52079887
26	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.50459562
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.48533922
28	Homologous recombination_Homo sapiens_hsa03440	1.45026151
29	Basal transcription factors_Homo sapiens_hsa03022	1.43006268
30	RNA degradation_Homo sapiens_hsa03018	1.40362832
31	Morphine addiction_Homo sapiens_hsa05032	1.33189099
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.31375751
33	Regulation of autophagy_Homo sapiens_hsa04140	1.27128951
34	Peroxisome_Homo sapiens_hsa04146	1.24698202
35	Taste transduction_Homo sapiens_hsa04742	1.23099572
36	Type I diabetes mellitus_Homo sapiens_hsa04940	1.22870348
37	Asthma_Homo sapiens_hsa05310	1.22153180
38	Propanoate metabolism_Homo sapiens_hsa00640	1.20076421
39	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.12986119
40	Parkinsons disease_Homo sapiens_hsa05012	1.11863170
41	Chemical carcinogenesis_Homo sapiens_hsa05204	1.08808039
42	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.07220032
43	Graft-versus-host disease_Homo sapiens_hsa05332	1.05807385
44	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.04715118
45	Serotonergic synapse_Homo sapiens_hsa04726	1.03472071
46	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.03188028
47	ABC transporters_Homo sapiens_hsa02010	1.03092655
48	Primary immunodeficiency_Homo sapiens_hsa05340	1.02886445
49	Olfactory transduction_Homo sapiens_hsa04740	1.00442200
50	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.97710898
51	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.95935439
52	GABAergic synapse_Homo sapiens_hsa04727	0.93254404
53	Collecting duct acid secretion_Homo sapiens_hsa04966	0.92858993
54	Allograft rejection_Homo sapiens_hsa05330	0.85607602
55	Retinol metabolism_Homo sapiens_hsa00830	0.84943042
56	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.84220615
57	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.82421516
58	Insulin secretion_Homo sapiens_hsa04911	0.81752841
59	Sulfur relay system_Homo sapiens_hsa04122	0.81577635
60	Proteasome_Homo sapiens_hsa03050	0.80973961
61	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.80952215
62	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.77418340
63	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.76953147
64	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.76394039
65	beta-Alanine metabolism_Homo sapiens_hsa00410	0.75695928
66	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.75620718
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.73578794
68	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.73297785
69	Purine metabolism_Homo sapiens_hsa00230	0.72219924
70	Fat digestion and absorption_Homo sapiens_hsa04975	0.69671128
71	Cardiac muscle contraction_Homo sapiens_hsa04260	0.69647858
72	Circadian entrainment_Homo sapiens_hsa04713	0.66957923
73	Glutamatergic synapse_Homo sapiens_hsa04724	0.66545522
74	Mineral absorption_Homo sapiens_hsa04978	0.66235463
75	Huntingtons disease_Homo sapiens_hsa05016	0.64880735
76	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.63846599
77	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.63077971
78	Rheumatoid arthritis_Homo sapiens_hsa05323	0.61477819
79	Alzheimers disease_Homo sapiens_hsa05010	0.59509602
80	Metabolic pathways_Homo sapiens_hsa01100	0.56239449
81	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.55722187
82	Pyrimidine metabolism_Homo sapiens_hsa00240	0.55635763
83	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.53259584
84	Antigen processing and presentation_Homo sapiens_hsa04612	0.53035969
85	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.50883276
86	Histidine metabolism_Homo sapiens_hsa00340	0.49809274
87	Glycerolipid metabolism_Homo sapiens_hsa00561	0.47813889
88	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.47810387
89	Salivary secretion_Homo sapiens_hsa04970	0.47131495
90	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.46674965
91	Steroid biosynthesis_Homo sapiens_hsa00100	0.44169695
92	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.42924463
93	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.40939503
94	Calcium signaling pathway_Homo sapiens_hsa04020	0.40218614
95	Circadian rhythm_Homo sapiens_hsa04710	0.40132689
96	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.32210980
97	Fatty acid degradation_Homo sapiens_hsa00071	0.31587804
98	Fatty acid metabolism_Homo sapiens_hsa01212	0.29285680
99	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.27048016
100	Dopaminergic synapse_Homo sapiens_hsa04728	0.25468858

LDHBP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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