LDHBP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)5.35019129
2proteasome assembly (GO:0043248)5.06191980
3establishment of protein localization to mitochondrial membrane (GO:0090151)4.80295623
4ATP synthesis coupled proton transport (GO:0015986)4.29043856
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.29043856
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.10070866
7maturation of SSU-rRNA (GO:0030490)4.07872624
8ribosomal small subunit assembly (GO:0000028)3.87052717
9GTP biosynthetic process (GO:0006183)3.86350469
10chaperone-mediated protein transport (GO:0072321)3.85452248
11tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.83552721
12RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.83552721
13DNA deamination (GO:0045006)3.83383043
14nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.80675147
15rRNA modification (GO:0000154)3.78752042
16maturation of 5.8S rRNA (GO:0000460)3.77899544
17exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.76776668
18mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.75991635
19mitochondrial respiratory chain complex I assembly (GO:0032981)3.75991635
20NADH dehydrogenase complex assembly (GO:0010257)3.75991635
21termination of RNA polymerase III transcription (GO:0006386)3.71150646
22transcription elongation from RNA polymerase III promoter (GO:0006385)3.71150646
23negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.63273113
24protein complex biogenesis (GO:0070271)3.62217665
25positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.60092381
26chromatin remodeling at centromere (GO:0031055)3.55814064
27rRNA methylation (GO:0031167)3.52179577
28DNA replication checkpoint (GO:0000076)3.47915800
29mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.42007053
30UTP biosynthetic process (GO:0006228)3.40170853
31mitochondrial respiratory chain complex assembly (GO:0033108)3.39871615
32DNA double-strand break processing (GO:0000729)3.38947944
33regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.36283202
34regulation of cellular amino acid metabolic process (GO:0006521)3.35430875
35CENP-A containing nucleosome assembly (GO:0034080)3.33361111
36positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.31136887
37regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.25312405
38DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.25245408
39negative regulation of DNA-dependent DNA replication (GO:2000104)3.24035256
40CTP biosynthetic process (GO:0006241)3.23487820
41CTP metabolic process (GO:0046036)3.23487820
42signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.22151824
43signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.22151824
44signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.22151824
45negative regulation of ligase activity (GO:0051352)3.21597676
46negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.21597676
47behavioral response to nicotine (GO:0035095)3.18821250
48rRNA processing (GO:0006364)3.17640428
49intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.17195237
50signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.17195237
51tRNA processing (GO:0008033)3.13762393
52epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.12673575
53water-soluble vitamin biosynthetic process (GO:0042364)3.11053760
54UTP metabolic process (GO:0046051)3.10918531
55RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.10684350
56cullin deneddylation (GO:0010388)3.10662186
57intracellular protein transmembrane import (GO:0044743)3.09359675
58rRNA metabolic process (GO:0016072)3.08954848
59regulation of mitotic spindle checkpoint (GO:1903504)3.08238611
60regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.08238611
61signal transduction involved in DNA damage checkpoint (GO:0072422)3.06233435
62signal transduction involved in DNA integrity checkpoint (GO:0072401)3.06233435
63regulation of isotype switching to IgG isotypes (GO:0048302)3.05393627
64viral mRNA export from host cell nucleus (GO:0046784)3.05271444
65anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.04996395
66respiratory electron transport chain (GO:0022904)3.04702911
67electron transport chain (GO:0022900)3.04495768
68signal transduction involved in cell cycle checkpoint (GO:0072395)3.03264639
69replication fork processing (GO:0031297)3.02640479
70respiratory chain complex IV assembly (GO:0008535)3.01973872
71pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.01593871
72spliceosomal snRNP assembly (GO:0000387)3.01354489
73protein peptidyl-prolyl isomerization (GO:0000413)3.01317786
74tRNA metabolic process (GO:0006399)3.01116871
75regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.98068831
76DNA catabolic process, exonucleolytic (GO:0000738)2.94780183
77pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.93628244
78tRNA aminoacylation (GO:0043039)2.91146459
79amino acid activation (GO:0043038)2.91146459
80IMP biosynthetic process (GO:0006188)2.89262601
81histone exchange (GO:0043486)2.87116577
82tRNA aminoacylation for protein translation (GO:0006418)2.86851755
83DNA damage response, detection of DNA damage (GO:0042769)2.84231985
84ribosome biogenesis (GO:0042254)2.83031420
85pseudouridine synthesis (GO:0001522)2.82456100
86somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.82429948
87isotype switching (GO:0045190)2.82429948
88somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.82429948
89protein deneddylation (GO:0000338)2.81913622
90negative regulation of telomere maintenance (GO:0032205)2.81415721
91cellular component biogenesis (GO:0044085)2.81326045
92ncRNA metabolic process (GO:0034660)2.80246455
93purine nucleoside triphosphate biosynthetic process (GO:0009145)2.80030458
94pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.79607815
95organelle disassembly (GO:1903008)2.79530566
96base-excision repair, AP site formation (GO:0006285)2.76957046
97positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.76614326
98ribosomal large subunit biogenesis (GO:0042273)2.76097075
99nucleobase biosynthetic process (GO:0046112)2.75968803
100histone mRNA metabolic process (GO:0008334)2.75212008

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.59790344
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.44181615
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.82617554
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.46443019
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.12248629
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.00073904
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.90045674
8VDR_22108803_ChIP-Seq_LS180_Human2.89565971
9ZNF274_21170338_ChIP-Seq_K562_Hela2.81454001
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.79692309
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.77651187
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.70811611
13VDR_23849224_ChIP-Seq_CD4+_Human2.58035747
14ELK1_19687146_ChIP-ChIP_HELA_Human2.53853624
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.47113848
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.41200190
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.40751895
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.38103756
19EZH2_22144423_ChIP-Seq_EOC_Human2.20253937
20FOXP3_21729870_ChIP-Seq_TREG_Human2.19848230
21EWS_26573619_Chip-Seq_HEK293_Human2.17948571
22E2F7_22180533_ChIP-Seq_HELA_Human2.10178404
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.08130373
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.94761516
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94667872
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.78234165
27PCGF2_27294783_Chip-Seq_NPCs_Mouse1.75691061
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.74766516
29MYC_19030024_ChIP-ChIP_MESCs_Mouse1.73394985
30MYC_18940864_ChIP-ChIP_HL60_Human1.72761976
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.72619924
32FUS_26573619_Chip-Seq_HEK293_Human1.69904009
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.66977498
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63245231
35TTF2_22483619_ChIP-Seq_HELA_Human1.58813245
36IGF1R_20145208_ChIP-Seq_DFB_Human1.56019417
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55921854
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53187409
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.52940229
40DCP1A_22483619_ChIP-Seq_HELA_Human1.48641430
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.45208263
42GABP_19822575_ChIP-Seq_HepG2_Human1.45174352
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44303009
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.42710138
45P300_19829295_ChIP-Seq_ESCs_Human1.42364081
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.38104613
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.36724069
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32265226
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31779905
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30061729
51TAF15_26573619_Chip-Seq_HEK293_Human1.28546514
52CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26784393
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.26754921
54MYC_19079543_ChIP-ChIP_MESCs_Mouse1.25570253
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22669675
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21677717
57TP53_22573176_ChIP-Seq_HFKS_Human1.20848862
58ELK1_22589737_ChIP-Seq_MCF10A_Human1.19063920
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.18060434
60EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.16838411
61E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16221199
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.14998910
63POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12958989
64FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12366311
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10570678
66MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.08841526
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07151541
68XRN2_22483619_ChIP-Seq_HELA_Human1.07091177
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06323801
70SOX2_19829295_ChIP-Seq_ESCs_Human1.05914998
71NANOG_19829295_ChIP-Seq_ESCs_Human1.05914998
72ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05534082
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.05174223
74POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02942364
75FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01313886
76ER_23166858_ChIP-Seq_MCF-7_Human1.00759909
77FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99963157
78FOXA1_25329375_ChIP-Seq_VCAP_Human0.99963157
79SALL1_21062744_ChIP-ChIP_HESCs_Human0.99883495
80AR_20517297_ChIP-Seq_VCAP_Human0.98684894
81IRF1_19129219_ChIP-ChIP_H3396_Human0.98443508
82NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98199171
83CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96921772
84TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95940932
85KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93626287
86CRX_20693478_ChIP-Seq_RETINA_Mouse0.91236736
87SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90975774
88NELFA_20434984_ChIP-Seq_ESCs_Mouse0.90004657
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88302442
90KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.88001990
91NCOR_22424771_ChIP-Seq_293T_Human0.87439339
92RBPJ_22232070_ChIP-Seq_NCS_Mouse0.86841662
93TCF4_22108803_ChIP-Seq_LS180_Human0.86447079
94NANOG_16153702_ChIP-ChIP_HESCs_Human0.85208962
95CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.84548701
96MYCN_18555785_ChIP-Seq_MESCs_Mouse0.82691839
97CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.81218791
98TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.80821753
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.80498537
100CBP_20019798_ChIP-Seq_JUKART_Human0.80498537

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.70423562
2MP0006292_abnormal_olfactory_placode3.54072078
3MP0008877_abnormal_DNA_methylation3.05097943
4MP0008058_abnormal_DNA_repair2.76106622
5MP0010094_abnormal_chromosome_stability2.43721073
6MP0002736_abnormal_nociception_after2.39205091
7MP0002102_abnormal_ear_morphology2.28097861
8MP0004957_abnormal_blastocyst_morpholog2.27674760
9MP0005084_abnormal_gallbladder_morpholo2.17009279
10MP0006072_abnormal_retinal_apoptosis2.15081742
11MP0003718_maternal_effect2.13937494
12MP0000372_irregular_coat_pigmentation1.99462989
13MP0001968_abnormal_touch/_nociception1.95902242
14MP0001529_abnormal_vocalization1.95454626
15MP0008789_abnormal_olfactory_epithelium1.94239781
16MP0008872_abnormal_physiological_respon1.93058629
17MP0008875_abnormal_xenobiotic_pharmacok1.92030821
18MP0003646_muscle_fatigue1.84765744
19MP0004142_abnormal_muscle_tone1.76963607
20MP0005671_abnormal_response_to1.70071945
21MP0001293_anophthalmia1.67969169
22MP0003787_abnormal_imprinting1.65963763
23MP0004145_abnormal_muscle_electrophysio1.64241520
24MP0004885_abnormal_endolymph1.63371911
25MP0003567_abnormal_fetal_cardiomyocyte1.62229189
26MP0002938_white_spotting1.59585851
27MP0005551_abnormal_eye_electrophysiolog1.54201310
28MP0003186_abnormal_redox_activity1.51325114
29MP0001485_abnormal_pinna_reflex1.50669514
30MP0009379_abnormal_foot_pigmentation1.47886285
31MP0005253_abnormal_eye_physiology1.46217370
32MP0003786_premature_aging1.43147135
33MP0006036_abnormal_mitochondrial_physio1.42779815
34MP0002138_abnormal_hepatobiliary_system1.40152916
35MP0003011_delayed_dark_adaptation1.38488366
36MP0003122_maternal_imprinting1.37890144
37MP0003890_abnormal_embryonic-extraembry1.33573849
38MP0004043_abnormal_pH_regulation1.31401728
39MP0005394_taste/olfaction_phenotype1.29251129
40MP0005499_abnormal_olfactory_system1.29251129
41MP0000569_abnormal_digit_pigmentation1.27128925
42MP0006276_abnormal_autonomic_nervous1.25262346
43MP0005645_abnormal_hypothalamus_physiol1.21338875
44MP0001835_abnormal_antigen_presentation1.21090910
45MP0005377_hearing/vestibular/ear_phenot1.21025162
46MP0003878_abnormal_ear_physiology1.21025162
47MP0002272_abnormal_nervous_system1.20890783
48MP0005167_abnormal_blood-brain_barrier1.18995867
49MP0008007_abnormal_cellular_replicative1.18192338
50MP0002234_abnormal_pharynx_morphology1.17897095
51MP0001873_stomach_inflammation1.14279297
52MP0003111_abnormal_nucleus_morphology1.13420405
53MP0001764_abnormal_homeostasis1.12482477
54MP0004147_increased_porphyrin_level1.11382391
55MP0003121_genomic_imprinting1.11114321
56MP0003195_calcinosis1.10275830
57MP0001984_abnormal_olfaction1.10055288
58MP0004742_abnormal_vestibular_system1.09022700
59MP0003119_abnormal_digestive_system1.07726571
60MP0009697_abnormal_copulation1.07578275
61MP0008932_abnormal_embryonic_tissue1.06993645
62MP0005646_abnormal_pituitary_gland1.06609728
63MP0002837_dystrophic_cardiac_calcinosis1.04475106
64MP0000049_abnormal_middle_ear1.04370028
65MP0005075_abnormal_melanosome_morpholog1.04195508
66MP0004133_heterotaxia1.04130277
67MP0001919_abnormal_reproductive_system1.02633625
68MP0002210_abnormal_sex_determination1.02133499
69MP0009745_abnormal_behavioral_response1.00234948
70MP0002751_abnormal_autonomic_nervous0.97867484
71MP0003880_abnormal_central_pattern0.97505851
72MP0002653_abnormal_ependyma_morphology0.95628303
73MP0002733_abnormal_thermal_nociception0.95548478
74MP0001905_abnormal_dopamine_level0.95381742
75MP0006035_abnormal_mitochondrial_morpho0.94355954
76MP0004782_abnormal_surfactant_physiolog0.94002797
77MP0001970_abnormal_pain_threshold0.92207229
78MP0003077_abnormal_cell_cycle0.91707978
79MP0001986_abnormal_taste_sensitivity0.91436091
80MP0005389_reproductive_system_phenotype0.91205311
81MP0001119_abnormal_female_reproductive0.88571665
82MP0000631_abnormal_neuroendocrine_gland0.87989822
83MP0002184_abnormal_innervation0.87715682
84MP0000653_abnormal_sex_gland0.84691767
85MP0001501_abnormal_sleep_pattern0.83825992
86MP0001929_abnormal_gametogenesis0.81787910
87MP0002277_abnormal_respiratory_mucosa0.81014548
88MP0001790_abnormal_immune_system0.79370781
89MP0005387_immune_system_phenotype0.79370781
90MP0009785_altered_susceptibility_to0.78380310
91MP0002638_abnormal_pupillary_reflex0.78298046
92MP0001440_abnormal_grooming_behavior0.78227501
93MP0002572_abnormal_emotion/affect_behav0.78002276
94MP0001486_abnormal_startle_reflex0.77585197
95MP0003936_abnormal_reproductive_system0.77381795
96MP0004215_abnormal_myocardial_fiber0.77033531
97MP0005195_abnormal_posterior_eye0.76282855
98MP0002095_abnormal_skin_pigmentation0.75936585
99MP0002735_abnormal_chemical_nociception0.75638389
100MP0002090_abnormal_vision0.75451183

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.45741873
2Increased hepatocellular lipid droplets (HP:0006565)3.98937874
3Acute encephalopathy (HP:0006846)3.93817150
4Abnormal mitochondria in muscle tissue (HP:0008316)3.83859310
5Mitochondrial inheritance (HP:0001427)3.77529272
6Lipid accumulation in hepatocytes (HP:0006561)3.74764986
7Increased CSF lactate (HP:0002490)3.66139418
8Progressive macrocephaly (HP:0004481)3.53920790
9Abnormality of the labia minora (HP:0012880)3.41969915
10Molar tooth sign on MRI (HP:0002419)3.35907067
11Abnormality of midbrain morphology (HP:0002418)3.35907067
12Pancreatic cysts (HP:0001737)3.28972838
13Pancreatic fibrosis (HP:0100732)3.17669329
14Renal Fanconi syndrome (HP:0001994)3.17667644
15Colon cancer (HP:0003003)3.12578521
16Cerebral edema (HP:0002181)2.95774384
17Reticulocytopenia (HP:0001896)2.94090994
18Nephronophthisis (HP:0000090)2.91650122
19Hepatocellular necrosis (HP:0001404)2.90956759
20Supernumerary spleens (HP:0009799)2.80321578
21Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.71462723
22Increased serum lactate (HP:0002151)2.68274210
23Hepatic necrosis (HP:0002605)2.59536521
24Optic disc pallor (HP:0000543)2.53254962
25Methylmalonic acidemia (HP:0002912)2.53114606
26Abnormality of the ileum (HP:0001549)2.52899716
27Bile duct proliferation (HP:0001408)2.50318931
28Abnormal biliary tract physiology (HP:0012439)2.50318931
29Abnormality of DNA repair (HP:0003254)2.48964062
30Abnormality of the renal medulla (HP:0100957)2.48950198
31Exertional dyspnea (HP:0002875)2.48556043
32Hypoproteinemia (HP:0003075)2.48358868
33Increased intramyocellular lipid droplets (HP:0012240)2.47970317
34Meckel diverticulum (HP:0002245)2.45420781
35True hermaphroditism (HP:0010459)2.44007678
36Reduced antithrombin III activity (HP:0001976)2.43873709
37Abnormality of the renal cortex (HP:0011035)2.43608124
38Medial flaring of the eyebrow (HP:0010747)2.40877162
39Leukodystrophy (HP:0002415)2.35058630
40Type I transferrin isoform profile (HP:0003642)2.33565161
41Abolished electroretinogram (ERG) (HP:0000550)2.28206164
42Respiratory difficulties (HP:0002880)2.27479373
43Abnormality of aspartate family amino acid metabolism (HP:0010899)2.26302576
44Aplasia/Hypoplasia of the spleen (HP:0010451)2.22444100
45Aplasia/Hypoplasia of the uvula (HP:0010293)2.22085891
46Methylmalonic aciduria (HP:0012120)2.22034434
47Pendular nystagmus (HP:0012043)2.18666502
48Exercise intolerance (HP:0003546)2.16100102
49Abnormality of the pons (HP:0007361)2.12577841
50Asplenia (HP:0001746)2.12377143
51Hyperglycinemia (HP:0002154)2.11372333
52Hypoplasia of the pons (HP:0012110)2.10030983
53Abnormal respiratory motile cilium morphology (HP:0005938)2.09633097
54Abnormal respiratory epithelium morphology (HP:0012253)2.09633097
55Lactic acidosis (HP:0003128)2.08795502
56Abnormal drinking behavior (HP:0030082)2.08314652
57Polydipsia (HP:0001959)2.08314652
58IgG deficiency (HP:0004315)2.07731349
59Respiratory failure (HP:0002878)2.04482010
60Polyuria (HP:0000103)2.03159229
61Tubular atrophy (HP:0000092)2.02990655
62Ectopic kidney (HP:0000086)2.02107064
63Horseshoe kidney (HP:0000085)2.01335974
64Increased muscle lipid content (HP:0009058)2.01275721
65Abnormality of serum amino acid levels (HP:0003112)2.01088042
66Lethargy (HP:0001254)2.00965681
67Stomatitis (HP:0010280)2.00775979
68Septo-optic dysplasia (HP:0100842)2.00708441
69Abnormality of alanine metabolism (HP:0010916)1.99978879
70Hyperalaninemia (HP:0003348)1.99978879
71Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.99978879
72Absent thumb (HP:0009777)1.99726949
733-Methylglutaconic aciduria (HP:0003535)1.99183450
74Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.98789457
75Abnormal protein N-linked glycosylation (HP:0012347)1.98789457
76Abnormal protein glycosylation (HP:0012346)1.98789457
77Abnormal glycosylation (HP:0012345)1.98789457
78Chromsome breakage (HP:0040012)1.94866881
79Cystic liver disease (HP:0006706)1.94796355
80Abnormality of methionine metabolism (HP:0010901)1.94446536
81Abnormality of the anterior horn cell (HP:0006802)1.94272803
82Degeneration of anterior horn cells (HP:0002398)1.94272803
83Dynein arm defect of respiratory motile cilia (HP:0012255)1.93567848
84Absent/shortened dynein arms (HP:0200106)1.93567848
85Congenital, generalized hypertrichosis (HP:0004540)1.93048292
86Type 2 muscle fiber atrophy (HP:0003554)1.91779298
87Abnormality of renal resorption (HP:0011038)1.91177778
88Abnormality of chromosome stability (HP:0003220)1.91177670
89Pancytopenia (HP:0001876)1.90866196
90Abnormal lung lobation (HP:0002101)1.89607954
91Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.89448398
92Chromosomal breakage induced by crosslinking agents (HP:0003221)1.89417500
93Absent rod-and cone-mediated responses on ERG (HP:0007688)1.88182584
94Gait imbalance (HP:0002141)1.88128954
95Decreased electroretinogram (ERG) amplitude (HP:0000654)1.86252743
96Postaxial foot polydactyly (HP:0001830)1.85788104
97Keratoconus (HP:0000563)1.84661260
98Increased corneal curvature (HP:0100692)1.84661260
99Congenital primary aphakia (HP:0007707)1.84608712
100Abnormal ciliary motility (HP:0012262)1.84519018

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK63.93808602
2TIE13.42343495
3MAP4K23.30216908
4VRK22.92780214
5MST42.83092226
6ZAK2.44606511
7SRPK12.41887551
8NUAK12.37842642
9TAF12.25876334
10BUB12.17197067
11NEK12.16197170
12TRIM282.14228305
13PLK31.95158337
14GRK11.91656347
15NME11.84225807
16MKNK11.82726120
17EIF2AK31.80746956
18TXK1.78231007
19STK161.74949126
20MAP3K121.71202434
21ADRBK21.64295778
22OXSR11.63061066
23WNK31.62846427
24MKNK21.61855226
25TLK11.59455636
26VRK11.57229936
27CDC71.45826035
28WNK41.43517768
29CDK191.41323396
30PLK41.38224283
31PNCK1.36110064
32EIF2AK11.33712541
33BMPR1B1.32292390
34CSNK1G31.29448863
35DYRK21.22818428
36PBK1.22312424
37CSNK1G21.18710169
38CSNK1G11.16778243
39CSNK1A1L1.15172924
40TEC1.06944264
41MAP3K40.99487223
42BCR0.98816237
43ATR0.98580731
44PASK0.97343588
45MAPK130.96967240
46BCKDK0.96464844
47WEE10.95733634
48TNIK0.90405161
49STK390.88745412
50PLK10.88123374
51MINK10.87712724
52EIF2AK20.84145026
53INSRR0.81752612
54TTK0.78813326
55PLK20.78612779
56DAPK10.76672965
57CAMKK20.71818856
58FRK0.68594455
59PRKCG0.66902941
60PDK20.60810839
61PINK10.59990621
62RPS6KA40.59983588
63PAK30.53524222
64CSNK2A20.52949610
65MAPKAPK50.52808144
66CSNK1E0.50130626
67CSNK2A10.49619946
68ATM0.49502754
69AURKB0.48063875
70GRK50.46212843
71TAOK30.46095216
72ALK0.44157053
73CLK10.43186963
74CHEK20.42974701
75TGFBR10.42610292
76FES0.41626098
77MAP2K70.41476701
78IKBKB0.40437024
79WNK10.39963084
80MAPKAPK30.38425405
81ERBB30.37570036
82CDK30.37150588
83PHKG20.37061072
84PHKG10.37061072
85RPS6KA50.36600070
86MAP2K60.34120881
87ITK0.33813561
88PRKCE0.33408350
89PRKDC0.32821337
90KDR0.32272996
91PRKACA0.31604116
92CSNK1A10.31450948
93NME20.28931481
94CHEK10.28297818
95CAMK2A0.28018799
96JAK30.28012045
97ACVR1B0.27684925
98CSNK1D0.24029009
99MATK0.23050394
100CAMK10.22246265

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.38337896
2Protein export_Homo sapiens_hsa030603.17238605
3Oxidative phosphorylation_Homo sapiens_hsa001902.98535431
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.93775432
5RNA polymerase_Homo sapiens_hsa030202.64764538
6Ribosome_Homo sapiens_hsa030102.61938312
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.56658980
8Mismatch repair_Homo sapiens_hsa034302.52746571
9Parkinsons disease_Homo sapiens_hsa050122.52304608
10Propanoate metabolism_Homo sapiens_hsa006402.35632486
11Homologous recombination_Homo sapiens_hsa034402.27388936
12DNA replication_Homo sapiens_hsa030302.23700153
13One carbon pool by folate_Homo sapiens_hsa006702.12133326
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.97436041
15Basal transcription factors_Homo sapiens_hsa030221.87347682
16RNA transport_Homo sapiens_hsa030131.87240608
17RNA degradation_Homo sapiens_hsa030181.85691803
18Nucleotide excision repair_Homo sapiens_hsa034201.85662707
19Fanconi anemia pathway_Homo sapiens_hsa034601.77873199
20Huntingtons disease_Homo sapiens_hsa050161.76277725
21Non-homologous end-joining_Homo sapiens_hsa034501.64264140
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.57480944
23Base excision repair_Homo sapiens_hsa034101.56618991
24Spliceosome_Homo sapiens_hsa030401.52963591
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.47828234
26Alzheimers disease_Homo sapiens_hsa050101.46825087
27Asthma_Homo sapiens_hsa053101.44756100
28Pyrimidine metabolism_Homo sapiens_hsa002401.42962753
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41346491
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.37575841
31Caffeine metabolism_Homo sapiens_hsa002321.31900515
32Pyruvate metabolism_Homo sapiens_hsa006201.31338815
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28170742
34Purine metabolism_Homo sapiens_hsa002301.25661385
35Steroid biosynthesis_Homo sapiens_hsa001001.24112696
36Allograft rejection_Homo sapiens_hsa053301.22627830
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21052570
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.19624576
39Linoleic acid metabolism_Homo sapiens_hsa005911.17397919
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.12347205
41Cardiac muscle contraction_Homo sapiens_hsa042601.11537328
42Butanoate metabolism_Homo sapiens_hsa006501.06464029
43Autoimmune thyroid disease_Homo sapiens_hsa053201.05129530
44Phototransduction_Homo sapiens_hsa047441.03321569
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02083263
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.00044688
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95802316
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92499903
49Peroxisome_Homo sapiens_hsa041460.91977126
50Type I diabetes mellitus_Homo sapiens_hsa049400.90259944
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89670907
52Tryptophan metabolism_Homo sapiens_hsa003800.89488997
53Nitrogen metabolism_Homo sapiens_hsa009100.83138831
54Primary immunodeficiency_Homo sapiens_hsa053400.76164230
55Fatty acid elongation_Homo sapiens_hsa000620.72650581
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71797643
57Nicotine addiction_Homo sapiens_hsa050330.71704471
58Metabolic pathways_Homo sapiens_hsa011000.70171103
59Retinol metabolism_Homo sapiens_hsa008300.70134844
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69552175
61Graft-versus-host disease_Homo sapiens_hsa053320.68471468
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66191518
63beta-Alanine metabolism_Homo sapiens_hsa004100.65843972
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64955764
65Fatty acid degradation_Homo sapiens_hsa000710.60921630
66Ether lipid metabolism_Homo sapiens_hsa005650.59492662
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59153697
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58596108
69Glutathione metabolism_Homo sapiens_hsa004800.58564397
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58524784
71Fat digestion and absorption_Homo sapiens_hsa049750.55902151
72Chemical carcinogenesis_Homo sapiens_hsa052040.53725781
73Arginine and proline metabolism_Homo sapiens_hsa003300.53467285
74Carbon metabolism_Homo sapiens_hsa012000.51896321
75Arachidonic acid metabolism_Homo sapiens_hsa005900.49451452
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.47813281
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45846061
78Biosynthesis of amino acids_Homo sapiens_hsa012300.44594020
79Olfactory transduction_Homo sapiens_hsa047400.44293026
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43480147
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43352782
82Rheumatoid arthritis_Homo sapiens_hsa053230.42109939
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41969722
84mRNA surveillance pathway_Homo sapiens_hsa030150.41015221
85Cell cycle_Homo sapiens_hsa041100.40870923
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38602358
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.37309469
88Epstein-Barr virus infection_Homo sapiens_hsa051690.36902009
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.35770847
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35674549
91Glycerolipid metabolism_Homo sapiens_hsa005610.34960063
92Folate biosynthesis_Homo sapiens_hsa007900.34743013
93Vitamin digestion and absorption_Homo sapiens_hsa049770.34739223
94N-Glycan biosynthesis_Homo sapiens_hsa005100.34523390
95Fatty acid metabolism_Homo sapiens_hsa012120.33764131
96Regulation of autophagy_Homo sapiens_hsa041400.31206671
97Taste transduction_Homo sapiens_hsa047420.29619026
98Systemic lupus erythematosus_Homo sapiens_hsa053220.28180718
99Morphine addiction_Homo sapiens_hsa050320.26853682
100Collecting duct acid secretion_Homo sapiens_hsa049660.24925766

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