

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | protein neddylation (GO:0045116) | 5.35019129 |
| 2 | proteasome assembly (GO:0043248) | 5.06191980 |
| 3 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.80295623 |
| 4 | ATP synthesis coupled proton transport (GO:0015986) | 4.29043856 |
| 5 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.29043856 |
| 6 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.10070866 |
| 7 | maturation of SSU-rRNA (GO:0030490) | 4.07872624 |
| 8 | ribosomal small subunit assembly (GO:0000028) | 3.87052717 |
| 9 | GTP biosynthetic process (GO:0006183) | 3.86350469 |
| 10 | chaperone-mediated protein transport (GO:0072321) | 3.85452248 |
| 11 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.83552721 |
| 12 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.83552721 |
| 13 | DNA deamination (GO:0045006) | 3.83383043 |
| 14 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.80675147 |
| 15 | rRNA modification (GO:0000154) | 3.78752042 |
| 16 | maturation of 5.8S rRNA (GO:0000460) | 3.77899544 |
| 17 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.76776668 |
| 18 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.75991635 |
| 19 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.75991635 |
| 20 | NADH dehydrogenase complex assembly (GO:0010257) | 3.75991635 |
| 21 | termination of RNA polymerase III transcription (GO:0006386) | 3.71150646 |
| 22 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.71150646 |
| 23 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.63273113 |
| 24 | protein complex biogenesis (GO:0070271) | 3.62217665 |
| 25 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 3.60092381 |
| 26 | chromatin remodeling at centromere (GO:0031055) | 3.55814064 |
| 27 | rRNA methylation (GO:0031167) | 3.52179577 |
| 28 | DNA replication checkpoint (GO:0000076) | 3.47915800 |
| 29 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.42007053 |
| 30 | UTP biosynthetic process (GO:0006228) | 3.40170853 |
| 31 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.39871615 |
| 32 | DNA double-strand break processing (GO:0000729) | 3.38947944 |
| 33 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 3.36283202 |
| 34 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.35430875 |
| 35 | CENP-A containing nucleosome assembly (GO:0034080) | 3.33361111 |
| 36 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.31136887 |
| 37 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.25312405 |
| 38 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.25245408 |
| 39 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.24035256 |
| 40 | CTP biosynthetic process (GO:0006241) | 3.23487820 |
| 41 | CTP metabolic process (GO:0046036) | 3.23487820 |
| 42 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.22151824 |
| 43 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.22151824 |
| 44 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.22151824 |
| 45 | negative regulation of ligase activity (GO:0051352) | 3.21597676 |
| 46 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.21597676 |
| 47 | behavioral response to nicotine (GO:0035095) | 3.18821250 |
| 48 | rRNA processing (GO:0006364) | 3.17640428 |
| 49 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.17195237 |
| 50 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.17195237 |
| 51 | tRNA processing (GO:0008033) | 3.13762393 |
| 52 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 3.12673575 |
| 53 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.11053760 |
| 54 | UTP metabolic process (GO:0046051) | 3.10918531 |
| 55 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.10684350 |
| 56 | cullin deneddylation (GO:0010388) | 3.10662186 |
| 57 | intracellular protein transmembrane import (GO:0044743) | 3.09359675 |
| 58 | rRNA metabolic process (GO:0016072) | 3.08954848 |
| 59 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.08238611 |
| 60 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.08238611 |
| 61 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.06233435 |
| 62 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.06233435 |
| 63 | regulation of isotype switching to IgG isotypes (GO:0048302) | 3.05393627 |
| 64 | viral mRNA export from host cell nucleus (GO:0046784) | 3.05271444 |
| 65 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.04996395 |
| 66 | respiratory electron transport chain (GO:0022904) | 3.04702911 |
| 67 | electron transport chain (GO:0022900) | 3.04495768 |
| 68 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.03264639 |
| 69 | replication fork processing (GO:0031297) | 3.02640479 |
| 70 | respiratory chain complex IV assembly (GO:0008535) | 3.01973872 |
| 71 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 3.01593871 |
| 72 | spliceosomal snRNP assembly (GO:0000387) | 3.01354489 |
| 73 | protein peptidyl-prolyl isomerization (GO:0000413) | 3.01317786 |
| 74 | tRNA metabolic process (GO:0006399) | 3.01116871 |
| 75 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 2.98068831 |
| 76 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.94780183 |
| 77 | pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209) | 2.93628244 |
| 78 | tRNA aminoacylation (GO:0043039) | 2.91146459 |
| 79 | amino acid activation (GO:0043038) | 2.91146459 |
| 80 | IMP biosynthetic process (GO:0006188) | 2.89262601 |
| 81 | histone exchange (GO:0043486) | 2.87116577 |
| 82 | tRNA aminoacylation for protein translation (GO:0006418) | 2.86851755 |
| 83 | DNA damage response, detection of DNA damage (GO:0042769) | 2.84231985 |
| 84 | ribosome biogenesis (GO:0042254) | 2.83031420 |
| 85 | pseudouridine synthesis (GO:0001522) | 2.82456100 |
| 86 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 2.82429948 |
| 87 | isotype switching (GO:0045190) | 2.82429948 |
| 88 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 2.82429948 |
| 89 | protein deneddylation (GO:0000338) | 2.81913622 |
| 90 | negative regulation of telomere maintenance (GO:0032205) | 2.81415721 |
| 91 | cellular component biogenesis (GO:0044085) | 2.81326045 |
| 92 | ncRNA metabolic process (GO:0034660) | 2.80246455 |
| 93 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.80030458 |
| 94 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 2.79607815 |
| 95 | organelle disassembly (GO:1903008) | 2.79530566 |
| 96 | base-excision repair, AP site formation (GO:0006285) | 2.76957046 |
| 97 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.76614326 |
| 98 | ribosomal large subunit biogenesis (GO:0042273) | 2.76097075 |
| 99 | nucleobase biosynthetic process (GO:0046112) | 2.75968803 |
| 100 | histone mRNA metabolic process (GO:0008334) | 2.75212008 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.59790344 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.44181615 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.82617554 |
| 4 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.46443019 |
| 5 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.12248629 |
| 6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.00073904 |
| 7 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.90045674 |
| 8 | VDR_22108803_ChIP-Seq_LS180_Human | 2.89565971 |
| 9 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.81454001 |
| 10 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.79692309 |
| 11 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.77651187 |
| 12 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.70811611 |
| 13 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.58035747 |
| 14 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.53853624 |
| 15 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.47113848 |
| 16 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.41200190 |
| 17 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.40751895 |
| 18 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.38103756 |
| 19 | EZH2_22144423_ChIP-Seq_EOC_Human | 2.20253937 |
| 20 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.19848230 |
| 21 | EWS_26573619_Chip-Seq_HEK293_Human | 2.17948571 |
| 22 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.10178404 |
| 23 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.08130373 |
| 24 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.94761516 |
| 25 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.94667872 |
| 26 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.78234165 |
| 27 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.75691061 |
| 28 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.74766516 |
| 29 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.73394985 |
| 30 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.72761976 |
| 31 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.72619924 |
| 32 | FUS_26573619_Chip-Seq_HEK293_Human | 1.69904009 |
| 33 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.66977498 |
| 34 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.63245231 |
| 35 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.58813245 |
| 36 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.56019417 |
| 37 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.55921854 |
| 38 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.53187409 |
| 39 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.52940229 |
| 40 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.48641430 |
| 41 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.45208263 |
| 42 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.45174352 |
| 43 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.44303009 |
| 44 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.42710138 |
| 45 | P300_19829295_ChIP-Seq_ESCs_Human | 1.42364081 |
| 46 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.38104613 |
| 47 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.36724069 |
| 48 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.32265226 |
| 49 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.31779905 |
| 50 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.30061729 |
| 51 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.28546514 |
| 52 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.26784393 |
| 53 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.26754921 |
| 54 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.25570253 |
| 55 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.22669675 |
| 56 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.21677717 |
| 57 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.20848862 |
| 58 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.19063920 |
| 59 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.18060434 |
| 60 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.16838411 |
| 61 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.16221199 |
| 62 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.14998910 |
| 63 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.12958989 |
| 64 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.12366311 |
| 65 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.10570678 |
| 66 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.08841526 |
| 67 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.07151541 |
| 68 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.07091177 |
| 69 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.06323801 |
| 70 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.05914998 |
| 71 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.05914998 |
| 72 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.05534082 |
| 73 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.05174223 |
| 74 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.02942364 |
| 75 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.01313886 |
| 76 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.00759909 |
| 77 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.99963157 |
| 78 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.99963157 |
| 79 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.99883495 |
| 80 | AR_20517297_ChIP-Seq_VCAP_Human | 0.98684894 |
| 81 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.98443508 |
| 82 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 0.98199171 |
| 83 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.96921772 |
| 84 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.95940932 |
| 85 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.93626287 |
| 86 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.91236736 |
| 87 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.90975774 |
| 88 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 0.90004657 |
| 89 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.88302442 |
| 90 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.88001990 |
| 91 | NCOR_22424771_ChIP-Seq_293T_Human | 0.87439339 |
| 92 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.86841662 |
| 93 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.86447079 |
| 94 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.85208962 |
| 95 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 0.84548701 |
| 96 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.82691839 |
| 97 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.81218791 |
| 98 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.80821753 |
| 99 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.80498537 |
| 100 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.80498537 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 3.70423562 |
| 2 | MP0006292_abnormal_olfactory_placode | 3.54072078 |
| 3 | MP0008877_abnormal_DNA_methylation | 3.05097943 |
| 4 | MP0008058_abnormal_DNA_repair | 2.76106622 |
| 5 | MP0010094_abnormal_chromosome_stability | 2.43721073 |
| 6 | MP0002736_abnormal_nociception_after | 2.39205091 |
| 7 | MP0002102_abnormal_ear_morphology | 2.28097861 |
| 8 | MP0004957_abnormal_blastocyst_morpholog | 2.27674760 |
| 9 | MP0005084_abnormal_gallbladder_morpholo | 2.17009279 |
| 10 | MP0006072_abnormal_retinal_apoptosis | 2.15081742 |
| 11 | MP0003718_maternal_effect | 2.13937494 |
| 12 | MP0000372_irregular_coat_pigmentation | 1.99462989 |
| 13 | MP0001968_abnormal_touch/_nociception | 1.95902242 |
| 14 | MP0001529_abnormal_vocalization | 1.95454626 |
| 15 | MP0008789_abnormal_olfactory_epithelium | 1.94239781 |
| 16 | MP0008872_abnormal_physiological_respon | 1.93058629 |
| 17 | MP0008875_abnormal_xenobiotic_pharmacok | 1.92030821 |
| 18 | MP0003646_muscle_fatigue | 1.84765744 |
| 19 | MP0004142_abnormal_muscle_tone | 1.76963607 |
| 20 | MP0005671_abnormal_response_to | 1.70071945 |
| 21 | MP0001293_anophthalmia | 1.67969169 |
| 22 | MP0003787_abnormal_imprinting | 1.65963763 |
| 23 | MP0004145_abnormal_muscle_electrophysio | 1.64241520 |
| 24 | MP0004885_abnormal_endolymph | 1.63371911 |
| 25 | MP0003567_abnormal_fetal_cardiomyocyte | 1.62229189 |
| 26 | MP0002938_white_spotting | 1.59585851 |
| 27 | MP0005551_abnormal_eye_electrophysiolog | 1.54201310 |
| 28 | MP0003186_abnormal_redox_activity | 1.51325114 |
| 29 | MP0001485_abnormal_pinna_reflex | 1.50669514 |
| 30 | MP0009379_abnormal_foot_pigmentation | 1.47886285 |
| 31 | MP0005253_abnormal_eye_physiology | 1.46217370 |
| 32 | MP0003786_premature_aging | 1.43147135 |
| 33 | MP0006036_abnormal_mitochondrial_physio | 1.42779815 |
| 34 | MP0002138_abnormal_hepatobiliary_system | 1.40152916 |
| 35 | MP0003011_delayed_dark_adaptation | 1.38488366 |
| 36 | MP0003122_maternal_imprinting | 1.37890144 |
| 37 | MP0003890_abnormal_embryonic-extraembry | 1.33573849 |
| 38 | MP0004043_abnormal_pH_regulation | 1.31401728 |
| 39 | MP0005394_taste/olfaction_phenotype | 1.29251129 |
| 40 | MP0005499_abnormal_olfactory_system | 1.29251129 |
| 41 | MP0000569_abnormal_digit_pigmentation | 1.27128925 |
| 42 | MP0006276_abnormal_autonomic_nervous | 1.25262346 |
| 43 | MP0005645_abnormal_hypothalamus_physiol | 1.21338875 |
| 44 | MP0001835_abnormal_antigen_presentation | 1.21090910 |
| 45 | MP0005377_hearing/vestibular/ear_phenot | 1.21025162 |
| 46 | MP0003878_abnormal_ear_physiology | 1.21025162 |
| 47 | MP0002272_abnormal_nervous_system | 1.20890783 |
| 48 | MP0005167_abnormal_blood-brain_barrier | 1.18995867 |
| 49 | MP0008007_abnormal_cellular_replicative | 1.18192338 |
| 50 | MP0002234_abnormal_pharynx_morphology | 1.17897095 |
| 51 | MP0001873_stomach_inflammation | 1.14279297 |
| 52 | MP0003111_abnormal_nucleus_morphology | 1.13420405 |
| 53 | MP0001764_abnormal_homeostasis | 1.12482477 |
| 54 | MP0004147_increased_porphyrin_level | 1.11382391 |
| 55 | MP0003121_genomic_imprinting | 1.11114321 |
| 56 | MP0003195_calcinosis | 1.10275830 |
| 57 | MP0001984_abnormal_olfaction | 1.10055288 |
| 58 | MP0004742_abnormal_vestibular_system | 1.09022700 |
| 59 | MP0003119_abnormal_digestive_system | 1.07726571 |
| 60 | MP0009697_abnormal_copulation | 1.07578275 |
| 61 | MP0008932_abnormal_embryonic_tissue | 1.06993645 |
| 62 | MP0005646_abnormal_pituitary_gland | 1.06609728 |
| 63 | MP0002837_dystrophic_cardiac_calcinosis | 1.04475106 |
| 64 | MP0000049_abnormal_middle_ear | 1.04370028 |
| 65 | MP0005075_abnormal_melanosome_morpholog | 1.04195508 |
| 66 | MP0004133_heterotaxia | 1.04130277 |
| 67 | MP0001919_abnormal_reproductive_system | 1.02633625 |
| 68 | MP0002210_abnormal_sex_determination | 1.02133499 |
| 69 | MP0009745_abnormal_behavioral_response | 1.00234948 |
| 70 | MP0002751_abnormal_autonomic_nervous | 0.97867484 |
| 71 | MP0003880_abnormal_central_pattern | 0.97505851 |
| 72 | MP0002653_abnormal_ependyma_morphology | 0.95628303 |
| 73 | MP0002733_abnormal_thermal_nociception | 0.95548478 |
| 74 | MP0001905_abnormal_dopamine_level | 0.95381742 |
| 75 | MP0006035_abnormal_mitochondrial_morpho | 0.94355954 |
| 76 | MP0004782_abnormal_surfactant_physiolog | 0.94002797 |
| 77 | MP0001970_abnormal_pain_threshold | 0.92207229 |
| 78 | MP0003077_abnormal_cell_cycle | 0.91707978 |
| 79 | MP0001986_abnormal_taste_sensitivity | 0.91436091 |
| 80 | MP0005389_reproductive_system_phenotype | 0.91205311 |
| 81 | MP0001119_abnormal_female_reproductive | 0.88571665 |
| 82 | MP0000631_abnormal_neuroendocrine_gland | 0.87989822 |
| 83 | MP0002184_abnormal_innervation | 0.87715682 |
| 84 | MP0000653_abnormal_sex_gland | 0.84691767 |
| 85 | MP0001501_abnormal_sleep_pattern | 0.83825992 |
| 86 | MP0001929_abnormal_gametogenesis | 0.81787910 |
| 87 | MP0002277_abnormal_respiratory_mucosa | 0.81014548 |
| 88 | MP0001790_abnormal_immune_system | 0.79370781 |
| 89 | MP0005387_immune_system_phenotype | 0.79370781 |
| 90 | MP0009785_altered_susceptibility_to | 0.78380310 |
| 91 | MP0002638_abnormal_pupillary_reflex | 0.78298046 |
| 92 | MP0001440_abnormal_grooming_behavior | 0.78227501 |
| 93 | MP0002572_abnormal_emotion/affect_behav | 0.78002276 |
| 94 | MP0001486_abnormal_startle_reflex | 0.77585197 |
| 95 | MP0003936_abnormal_reproductive_system | 0.77381795 |
| 96 | MP0004215_abnormal_myocardial_fiber | 0.77033531 |
| 97 | MP0005195_abnormal_posterior_eye | 0.76282855 |
| 98 | MP0002095_abnormal_skin_pigmentation | 0.75936585 |
| 99 | MP0002735_abnormal_chemical_nociception | 0.75638389 |
| 100 | MP0002090_abnormal_vision | 0.75451183 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.45741873 |
| 2 | Increased hepatocellular lipid droplets (HP:0006565) | 3.98937874 |
| 3 | Acute encephalopathy (HP:0006846) | 3.93817150 |
| 4 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.83859310 |
| 5 | Mitochondrial inheritance (HP:0001427) | 3.77529272 |
| 6 | Lipid accumulation in hepatocytes (HP:0006561) | 3.74764986 |
| 7 | Increased CSF lactate (HP:0002490) | 3.66139418 |
| 8 | Progressive macrocephaly (HP:0004481) | 3.53920790 |
| 9 | Abnormality of the labia minora (HP:0012880) | 3.41969915 |
| 10 | Molar tooth sign on MRI (HP:0002419) | 3.35907067 |
| 11 | Abnormality of midbrain morphology (HP:0002418) | 3.35907067 |
| 12 | Pancreatic cysts (HP:0001737) | 3.28972838 |
| 13 | Pancreatic fibrosis (HP:0100732) | 3.17669329 |
| 14 | Renal Fanconi syndrome (HP:0001994) | 3.17667644 |
| 15 | Colon cancer (HP:0003003) | 3.12578521 |
| 16 | Cerebral edema (HP:0002181) | 2.95774384 |
| 17 | Reticulocytopenia (HP:0001896) | 2.94090994 |
| 18 | Nephronophthisis (HP:0000090) | 2.91650122 |
| 19 | Hepatocellular necrosis (HP:0001404) | 2.90956759 |
| 20 | Supernumerary spleens (HP:0009799) | 2.80321578 |
| 21 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.71462723 |
| 22 | Increased serum lactate (HP:0002151) | 2.68274210 |
| 23 | Hepatic necrosis (HP:0002605) | 2.59536521 |
| 24 | Optic disc pallor (HP:0000543) | 2.53254962 |
| 25 | Methylmalonic acidemia (HP:0002912) | 2.53114606 |
| 26 | Abnormality of the ileum (HP:0001549) | 2.52899716 |
| 27 | Bile duct proliferation (HP:0001408) | 2.50318931 |
| 28 | Abnormal biliary tract physiology (HP:0012439) | 2.50318931 |
| 29 | Abnormality of DNA repair (HP:0003254) | 2.48964062 |
| 30 | Abnormality of the renal medulla (HP:0100957) | 2.48950198 |
| 31 | Exertional dyspnea (HP:0002875) | 2.48556043 |
| 32 | Hypoproteinemia (HP:0003075) | 2.48358868 |
| 33 | Increased intramyocellular lipid droplets (HP:0012240) | 2.47970317 |
| 34 | Meckel diverticulum (HP:0002245) | 2.45420781 |
| 35 | True hermaphroditism (HP:0010459) | 2.44007678 |
| 36 | Reduced antithrombin III activity (HP:0001976) | 2.43873709 |
| 37 | Abnormality of the renal cortex (HP:0011035) | 2.43608124 |
| 38 | Medial flaring of the eyebrow (HP:0010747) | 2.40877162 |
| 39 | Leukodystrophy (HP:0002415) | 2.35058630 |
| 40 | Type I transferrin isoform profile (HP:0003642) | 2.33565161 |
| 41 | Abolished electroretinogram (ERG) (HP:0000550) | 2.28206164 |
| 42 | Respiratory difficulties (HP:0002880) | 2.27479373 |
| 43 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.26302576 |
| 44 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 2.22444100 |
| 45 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.22085891 |
| 46 | Methylmalonic aciduria (HP:0012120) | 2.22034434 |
| 47 | Pendular nystagmus (HP:0012043) | 2.18666502 |
| 48 | Exercise intolerance (HP:0003546) | 2.16100102 |
| 49 | Abnormality of the pons (HP:0007361) | 2.12577841 |
| 50 | Asplenia (HP:0001746) | 2.12377143 |
| 51 | Hyperglycinemia (HP:0002154) | 2.11372333 |
| 52 | Hypoplasia of the pons (HP:0012110) | 2.10030983 |
| 53 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.09633097 |
| 54 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.09633097 |
| 55 | Lactic acidosis (HP:0003128) | 2.08795502 |
| 56 | Abnormal drinking behavior (HP:0030082) | 2.08314652 |
| 57 | Polydipsia (HP:0001959) | 2.08314652 |
| 58 | IgG deficiency (HP:0004315) | 2.07731349 |
| 59 | Respiratory failure (HP:0002878) | 2.04482010 |
| 60 | Polyuria (HP:0000103) | 2.03159229 |
| 61 | Tubular atrophy (HP:0000092) | 2.02990655 |
| 62 | Ectopic kidney (HP:0000086) | 2.02107064 |
| 63 | Horseshoe kidney (HP:0000085) | 2.01335974 |
| 64 | Increased muscle lipid content (HP:0009058) | 2.01275721 |
| 65 | Abnormality of serum amino acid levels (HP:0003112) | 2.01088042 |
| 66 | Lethargy (HP:0001254) | 2.00965681 |
| 67 | Stomatitis (HP:0010280) | 2.00775979 |
| 68 | Septo-optic dysplasia (HP:0100842) | 2.00708441 |
| 69 | Abnormality of alanine metabolism (HP:0010916) | 1.99978879 |
| 70 | Hyperalaninemia (HP:0003348) | 1.99978879 |
| 71 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.99978879 |
| 72 | Absent thumb (HP:0009777) | 1.99726949 |
| 73 | 3-Methylglutaconic aciduria (HP:0003535) | 1.99183450 |
| 74 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.98789457 |
| 75 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.98789457 |
| 76 | Abnormal protein glycosylation (HP:0012346) | 1.98789457 |
| 77 | Abnormal glycosylation (HP:0012345) | 1.98789457 |
| 78 | Chromsome breakage (HP:0040012) | 1.94866881 |
| 79 | Cystic liver disease (HP:0006706) | 1.94796355 |
| 80 | Abnormality of methionine metabolism (HP:0010901) | 1.94446536 |
| 81 | Abnormality of the anterior horn cell (HP:0006802) | 1.94272803 |
| 82 | Degeneration of anterior horn cells (HP:0002398) | 1.94272803 |
| 83 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 1.93567848 |
| 84 | Absent/shortened dynein arms (HP:0200106) | 1.93567848 |
| 85 | Congenital, generalized hypertrichosis (HP:0004540) | 1.93048292 |
| 86 | Type 2 muscle fiber atrophy (HP:0003554) | 1.91779298 |
| 87 | Abnormality of renal resorption (HP:0011038) | 1.91177778 |
| 88 | Abnormality of chromosome stability (HP:0003220) | 1.91177670 |
| 89 | Pancytopenia (HP:0001876) | 1.90866196 |
| 90 | Abnormal lung lobation (HP:0002101) | 1.89607954 |
| 91 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.89448398 |
| 92 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.89417500 |
| 93 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 1.88182584 |
| 94 | Gait imbalance (HP:0002141) | 1.88128954 |
| 95 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.86252743 |
| 96 | Postaxial foot polydactyly (HP:0001830) | 1.85788104 |
| 97 | Keratoconus (HP:0000563) | 1.84661260 |
| 98 | Increased corneal curvature (HP:0100692) | 1.84661260 |
| 99 | Congenital primary aphakia (HP:0007707) | 1.84608712 |
| 100 | Abnormal ciliary motility (HP:0012262) | 1.84519018 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TSSK6 | 3.93808602 |
| 2 | TIE1 | 3.42343495 |
| 3 | MAP4K2 | 3.30216908 |
| 4 | VRK2 | 2.92780214 |
| 5 | MST4 | 2.83092226 |
| 6 | ZAK | 2.44606511 |
| 7 | SRPK1 | 2.41887551 |
| 8 | NUAK1 | 2.37842642 |
| 9 | TAF1 | 2.25876334 |
| 10 | BUB1 | 2.17197067 |
| 11 | NEK1 | 2.16197170 |
| 12 | TRIM28 | 2.14228305 |
| 13 | PLK3 | 1.95158337 |
| 14 | GRK1 | 1.91656347 |
| 15 | NME1 | 1.84225807 |
| 16 | MKNK1 | 1.82726120 |
| 17 | EIF2AK3 | 1.80746956 |
| 18 | TXK | 1.78231007 |
| 19 | STK16 | 1.74949126 |
| 20 | MAP3K12 | 1.71202434 |
| 21 | ADRBK2 | 1.64295778 |
| 22 | OXSR1 | 1.63061066 |
| 23 | WNK3 | 1.62846427 |
| 24 | MKNK2 | 1.61855226 |
| 25 | TLK1 | 1.59455636 |
| 26 | VRK1 | 1.57229936 |
| 27 | CDC7 | 1.45826035 |
| 28 | WNK4 | 1.43517768 |
| 29 | CDK19 | 1.41323396 |
| 30 | PLK4 | 1.38224283 |
| 31 | PNCK | 1.36110064 |
| 32 | EIF2AK1 | 1.33712541 |
| 33 | BMPR1B | 1.32292390 |
| 34 | CSNK1G3 | 1.29448863 |
| 35 | DYRK2 | 1.22818428 |
| 36 | PBK | 1.22312424 |
| 37 | CSNK1G2 | 1.18710169 |
| 38 | CSNK1G1 | 1.16778243 |
| 39 | CSNK1A1L | 1.15172924 |
| 40 | TEC | 1.06944264 |
| 41 | MAP3K4 | 0.99487223 |
| 42 | BCR | 0.98816237 |
| 43 | ATR | 0.98580731 |
| 44 | PASK | 0.97343588 |
| 45 | MAPK13 | 0.96967240 |
| 46 | BCKDK | 0.96464844 |
| 47 | WEE1 | 0.95733634 |
| 48 | TNIK | 0.90405161 |
| 49 | STK39 | 0.88745412 |
| 50 | PLK1 | 0.88123374 |
| 51 | MINK1 | 0.87712724 |
| 52 | EIF2AK2 | 0.84145026 |
| 53 | INSRR | 0.81752612 |
| 54 | TTK | 0.78813326 |
| 55 | PLK2 | 0.78612779 |
| 56 | DAPK1 | 0.76672965 |
| 57 | CAMKK2 | 0.71818856 |
| 58 | FRK | 0.68594455 |
| 59 | PRKCG | 0.66902941 |
| 60 | PDK2 | 0.60810839 |
| 61 | PINK1 | 0.59990621 |
| 62 | RPS6KA4 | 0.59983588 |
| 63 | PAK3 | 0.53524222 |
| 64 | CSNK2A2 | 0.52949610 |
| 65 | MAPKAPK5 | 0.52808144 |
| 66 | CSNK1E | 0.50130626 |
| 67 | CSNK2A1 | 0.49619946 |
| 68 | ATM | 0.49502754 |
| 69 | AURKB | 0.48063875 |
| 70 | GRK5 | 0.46212843 |
| 71 | TAOK3 | 0.46095216 |
| 72 | ALK | 0.44157053 |
| 73 | CLK1 | 0.43186963 |
| 74 | CHEK2 | 0.42974701 |
| 75 | TGFBR1 | 0.42610292 |
| 76 | FES | 0.41626098 |
| 77 | MAP2K7 | 0.41476701 |
| 78 | IKBKB | 0.40437024 |
| 79 | WNK1 | 0.39963084 |
| 80 | MAPKAPK3 | 0.38425405 |
| 81 | ERBB3 | 0.37570036 |
| 82 | CDK3 | 0.37150588 |
| 83 | PHKG2 | 0.37061072 |
| 84 | PHKG1 | 0.37061072 |
| 85 | RPS6KA5 | 0.36600070 |
| 86 | MAP2K6 | 0.34120881 |
| 87 | ITK | 0.33813561 |
| 88 | PRKCE | 0.33408350 |
| 89 | PRKDC | 0.32821337 |
| 90 | KDR | 0.32272996 |
| 91 | PRKACA | 0.31604116 |
| 92 | CSNK1A1 | 0.31450948 |
| 93 | NME2 | 0.28931481 |
| 94 | CHEK1 | 0.28297818 |
| 95 | CAMK2A | 0.28018799 |
| 96 | JAK3 | 0.28012045 |
| 97 | ACVR1B | 0.27684925 |
| 98 | CSNK1D | 0.24029009 |
| 99 | MATK | 0.23050394 |
| 100 | CAMK1 | 0.22246265 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.38337896 |
| 2 | Protein export_Homo sapiens_hsa03060 | 3.17238605 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.98535431 |
| 4 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.93775432 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 2.64764538 |
| 6 | Ribosome_Homo sapiens_hsa03010 | 2.61938312 |
| 7 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.56658980 |
| 8 | Mismatch repair_Homo sapiens_hsa03430 | 2.52746571 |
| 9 | Parkinsons disease_Homo sapiens_hsa05012 | 2.52304608 |
| 10 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.35632486 |
| 11 | Homologous recombination_Homo sapiens_hsa03440 | 2.27388936 |
| 12 | DNA replication_Homo sapiens_hsa03030 | 2.23700153 |
| 13 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.12133326 |
| 14 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.97436041 |
| 15 | Basal transcription factors_Homo sapiens_hsa03022 | 1.87347682 |
| 16 | RNA transport_Homo sapiens_hsa03013 | 1.87240608 |
| 17 | RNA degradation_Homo sapiens_hsa03018 | 1.85691803 |
| 18 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.85662707 |
| 19 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.77873199 |
| 20 | Huntingtons disease_Homo sapiens_hsa05016 | 1.76277725 |
| 21 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.64264140 |
| 22 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.57480944 |
| 23 | Base excision repair_Homo sapiens_hsa03410 | 1.56618991 |
| 24 | Spliceosome_Homo sapiens_hsa03040 | 1.52963591 |
| 25 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.47828234 |
| 26 | Alzheimers disease_Homo sapiens_hsa05010 | 1.46825087 |
| 27 | Asthma_Homo sapiens_hsa05310 | 1.44756100 |
| 28 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.42962753 |
| 29 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.41346491 |
| 30 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.37575841 |
| 31 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.31900515 |
| 32 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.31338815 |
| 33 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.28170742 |
| 34 | Purine metabolism_Homo sapiens_hsa00230 | 1.25661385 |
| 35 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.24112696 |
| 36 | Allograft rejection_Homo sapiens_hsa05330 | 1.22627830 |
| 37 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.21052570 |
| 38 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.19624576 |
| 39 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.17397919 |
| 40 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.12347205 |
| 41 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.11537328 |
| 42 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.06464029 |
| 43 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.05129530 |
| 44 | Phototransduction_Homo sapiens_hsa04744 | 1.03321569 |
| 45 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 1.02083263 |
| 46 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.00044688 |
| 47 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.95802316 |
| 48 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.92499903 |
| 49 | Peroxisome_Homo sapiens_hsa04146 | 0.91977126 |
| 50 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.90259944 |
| 51 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.89670907 |
| 52 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.89488997 |
| 53 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.83138831 |
| 54 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.76164230 |
| 55 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.72650581 |
| 56 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.71797643 |
| 57 | Nicotine addiction_Homo sapiens_hsa05033 | 0.71704471 |
| 58 | Metabolic pathways_Homo sapiens_hsa01100 | 0.70171103 |
| 59 | Retinol metabolism_Homo sapiens_hsa00830 | 0.70134844 |
| 60 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.69552175 |
| 61 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.68471468 |
| 62 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.66191518 |
| 63 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.65843972 |
| 64 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.64955764 |
| 65 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.60921630 |
| 66 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.59492662 |
| 67 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.59153697 |
| 68 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.58596108 |
| 69 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.58564397 |
| 70 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.58524784 |
| 71 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.55902151 |
| 72 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.53725781 |
| 73 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.53467285 |
| 74 | Carbon metabolism_Homo sapiens_hsa01200 | 0.51896321 |
| 75 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.49451452 |
| 76 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.47813281 |
| 77 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.45846061 |
| 78 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.44594020 |
| 79 | Olfactory transduction_Homo sapiens_hsa04740 | 0.44293026 |
| 80 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.43480147 |
| 81 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.43352782 |
| 82 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.42109939 |
| 83 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.41969722 |
| 84 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.41015221 |
| 85 | Cell cycle_Homo sapiens_hsa04110 | 0.40870923 |
| 86 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.38602358 |
| 87 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.37309469 |
| 88 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.36902009 |
| 89 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.35770847 |
| 90 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.35674549 |
| 91 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.34960063 |
| 92 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.34743013 |
| 93 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.34739223 |
| 94 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.34523390 |
| 95 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.33764131 |
| 96 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.31206671 |
| 97 | Taste transduction_Homo sapiens_hsa04742 | 0.29619026 |
| 98 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.28180718 |
| 99 | Morphine addiction_Homo sapiens_hsa05032 | 0.26853682 |
| 100 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.24925766 |

