LDHC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Lactate dehydrogenase C catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. LDHC is testis-specific and belongs to the lactate dehydrogenase family. Two transcript variants have been detected which differ in the 5' untranslated region. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.98169770
2reproduction (GO:0000003)9.45827962
3motile cilium assembly (GO:0044458)9.33917511
4spermatid development (GO:0007286)9.32267434
5male meiosis (GO:0007140)9.06947990
6cilium movement (GO:0003341)8.60103636
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.56939180
8synaptonemal complex organization (GO:0070193)8.29250238
9regulation of cilium movement (GO:0003352)7.94410186
10synaptonemal complex assembly (GO:0007130)7.92319776
11single fertilization (GO:0007338)7.62740812
12sperm capacitation (GO:0048240)6.84963628
13fertilization (GO:0009566)6.53351715
14DNA methylation involved in gamete generation (GO:0043046)6.40550875
15negative regulation of inclusion body assembly (GO:0090084)6.13892026
16male meiosis I (GO:0007141)6.04024580
17spermatogenesis (GO:0007283)6.02176924
18male gamete generation (GO:0048232)6.00050875
19chromosome organization involved in meiosis (GO:0070192)5.61152797
20gamete generation (GO:0007276)5.51665543
21ventricular system development (GO:0021591)5.49527516
22cellular process involved in reproduction in multicellular organism (GO:0022412)5.37815303
23germ cell development (GO:0007281)5.36705664
24microtubule depolymerization (GO:0007019)5.35450228
25meiotic nuclear division (GO:0007126)5.23339291
26organic cation transport (GO:0015695)5.21083936
27regulation of inclusion body assembly (GO:0090083)5.02131325
28cell recognition (GO:0008037)4.90767756
29meiosis I (GO:0007127)4.88710854
30seminiferous tubule development (GO:0072520)4.86163578
31calcium ion-dependent exocytosis (GO:0017156)4.81296964
32regulation of microtubule-based movement (GO:0060632)4.70180953
33microtubule severing (GO:0051013)4.50278699
34meiotic cell cycle (GO:0051321)4.35410763
35monoubiquitinated protein deubiquitination (GO:0035520)4.34618755
36multicellular organismal reproductive process (GO:0048609)4.33746303
37protein localization to cilium (GO:0061512)4.30650165
38left/right pattern formation (GO:0060972)4.17495186
39spermatid nucleus differentiation (GO:0007289)4.14866119
40genitalia morphogenesis (GO:0035112)4.07190511
41replication fork processing (GO:0031297)3.90406337
42glycerol ether metabolic process (GO:0006662)3.81868740
43chaperone-mediated protein complex assembly (GO:0051131)3.79910789
44gene silencing by RNA (GO:0031047)3.76479315
45intraciliary transport (GO:0042073)3.72063548
46protein polyglutamylation (GO:0018095)3.58376179
47platelet dense granule organization (GO:0060155)3.56000842
48ether metabolic process (GO:0018904)3.52543699
49multicellular organismal development (GO:0007275)3.51838282
50protein neddylation (GO:0045116)3.50675965
51synapsis (GO:0007129)3.46139638
52negative regulation of organelle assembly (GO:1902116)3.37968115
53axoneme assembly (GO:0035082)3.35389047
54meiotic cell cycle process (GO:1903046)3.34787004
55resolution of meiotic recombination intermediates (GO:0000712)3.34093181
56DNA double-strand break processing (GO:0000729)3.32797149
57chromatin remodeling at centromere (GO:0031055)3.31838713
58protein K6-linked ubiquitination (GO:0085020)3.31837203
59microtubule-based movement (GO:0007018)3.30440563
60chromosome condensation (GO:0030261)3.29352593
61meiotic chromosome segregation (GO:0045132)3.25814246
62amino-acid betaine transport (GO:0015838)3.24731060
63carnitine transport (GO:0015879)3.24731060
64somatic diversification of immune receptors via somatic mutation (GO:0002566)3.23648916
65somatic hypermutation of immunoglobulin genes (GO:0016446)3.23648916
66regulation of centriole replication (GO:0046599)3.22973377
67carnitine transmembrane transport (GO:1902603)3.21221668
68DNA packaging (GO:0006323)3.17810535
69regulation of nuclear cell cycle DNA replication (GO:0033262)3.16977145
70regulation of meiosis I (GO:0060631)3.14895442
71alditol metabolic process (GO:0019400)3.12405055
72maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.12346048
73reciprocal meiotic recombination (GO:0007131)3.10890204
74reciprocal DNA recombination (GO:0035825)3.10890204
75water-soluble vitamin biosynthetic process (GO:0042364)3.10147628
76CENP-A containing nucleosome assembly (GO:0034080)3.09705233
77cilium organization (GO:0044782)3.09315376
78nuclear pore complex assembly (GO:0051292)3.09223873
79protein refolding (GO:0042026)3.07771184
80indolalkylamine metabolic process (GO:0006586)3.07243052
81histone exchange (GO:0043486)3.06617397
82establishment of protein localization to mitochondrial membrane (GO:0090151)3.06053517
83polyol catabolic process (GO:0046174)3.05451893
84positive regulation of meiosis (GO:0045836)3.02645014
85nucleoside diphosphate phosphorylation (GO:0006165)3.00995452
86negative regulation of DNA-dependent DNA replication (GO:2000104)3.00194273
87tachykinin receptor signaling pathway (GO:0007217)2.99877719
88regulation of spindle checkpoint (GO:0090231)2.99375968
89serotonin metabolic process (GO:0042428)2.96799367
90protein K11-linked deubiquitination (GO:0035871)2.96708089
91behavioral response to nicotine (GO:0035095)2.96050419
92detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.94867831
93recombinational repair (GO:0000725)2.93775077
94double-strand break repair via homologous recombination (GO:0000724)2.92957586
95cilium assembly (GO:0042384)2.92591670
96regulation of protein polyubiquitination (GO:1902914)2.91772855
97centriole assembly (GO:0098534)2.90579461
98centriole replication (GO:0007099)2.90531934
99cellular component assembly involved in morphogenesis (GO:0010927)2.89320860
100regulation of action potential (GO:0098900)2.88831646
101keratinocyte development (GO:0003334)2.88412945
102cilium morphogenesis (GO:0060271)2.87885517
103positive regulation of meiotic cell cycle (GO:0051446)2.87279034
104mitotic sister chromatid cohesion (GO:0007064)2.86166980
105retinal cone cell development (GO:0046549)2.84224670
106GTP biosynthetic process (GO:0006183)2.82752857
107neural tube formation (GO:0001841)2.81081689
108DNA replication checkpoint (GO:0000076)2.80255945
109nucleus organization (GO:0006997)2.76787175
110primary amino compound metabolic process (GO:1901160)2.74871510
111glycerol metabolic process (GO:0006071)2.74622429
112microtubule polymerization or depolymerization (GO:0031109)2.74397674
113limb bud formation (GO:0060174)2.74134424
114single strand break repair (GO:0000012)2.73106059
115nonmotile primary cilium assembly (GO:0035058)2.72359516
116tryptophan catabolic process (GO:0006569)2.72178796
117indole-containing compound catabolic process (GO:0042436)2.72178796
118indolalkylamine catabolic process (GO:0046218)2.72178796
119photoreceptor cell maintenance (GO:0045494)2.71684352
120gene silencing (GO:0016458)2.71166379
121detection of light stimulus involved in visual perception (GO:0050908)2.68818597
122detection of light stimulus involved in sensory perception (GO:0050962)2.68818597
123regulation of mitotic spindle checkpoint (GO:1903504)2.67592355
124regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.67592355
125response to pheromone (GO:0019236)2.66730866
126tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.66135325
127RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.66135325
128negative regulation of DNA repair (GO:0045738)2.64682614
129negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.63553839
130RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.63405185
131gonadal mesoderm development (GO:0007506)2.60446277
132DNA-dependent DNA replication (GO:0006261)2.60402611
133sequestering of actin monomers (GO:0042989)2.60157306
134negative regulation of transcription regulatory region DNA binding (GO:2000678)2.59152164
135behavioral response to ethanol (GO:0048149)2.54357597
136preassembly of GPI anchor in ER membrane (GO:0016254)2.54351094
137kynurenine metabolic process (GO:0070189)2.53746761
138peptidyl-glutamic acid modification (GO:0018200)2.53372047
139UTP biosynthetic process (GO:0006228)2.52598344
140G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.52536821
141female gamete generation (GO:0007292)2.51761237
142mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.51377727
143mitochondrial respiratory chain complex I assembly (GO:0032981)2.51377727
144NADH dehydrogenase complex assembly (GO:0010257)2.51377727
145regulation of acrosome reaction (GO:0060046)2.50961593
146L-fucose catabolic process (GO:0042355)2.50736635
147fucose catabolic process (GO:0019317)2.50736635
148L-fucose metabolic process (GO:0042354)2.50736635
149somite development (GO:0061053)2.50374338
150L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.47935341
151respiratory chain complex IV assembly (GO:0008535)2.47851719
152proteasome assembly (GO:0043248)2.47711780
153indole-containing compound metabolic process (GO:0042430)2.45785802
154protein complex biogenesis (GO:0070271)2.45538915
155regulation of Golgi to plasma membrane protein transport (GO:0042996)2.45326947
156sexual reproduction (GO:0019953)2.44251578
157somite rostral/caudal axis specification (GO:0032525)2.42742910
158nuclear pore organization (GO:0006999)2.42429157
159termination of RNA polymerase III transcription (GO:0006386)2.42024886
160transcription elongation from RNA polymerase III promoter (GO:0006385)2.42024886
161sex differentiation (GO:0007548)2.40691859
162cilium or flagellum-dependent cell motility (GO:0001539)14.3309902
163fusion of sperm to egg plasma membrane (GO:0007342)14.1126682
164* sperm motility (GO:0030317)12.0614283
165acrosome assembly (GO:0001675)11.7736017
166multicellular organism reproduction (GO:0032504)11.4627835
167sperm-egg recognition (GO:0035036)11.3745678
168axonemal dynein complex assembly (GO:0070286)10.7955771
169cell wall macromolecule catabolic process (GO:0016998)10.7547910
170cell wall macromolecule metabolic process (GO:0044036)10.7547910
171plasma membrane fusion (GO:0045026)10.7509042
172acrosome reaction (GO:0007340)10.4520095
173binding of sperm to zona pellucida (GO:0007339)10.3883841
174cell-cell recognition (GO:0009988)10.1802927
175piRNA metabolic process (GO:0034587)10.0277999

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.14302100
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.76818681
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.63282891
4GBX2_23144817_ChIP-Seq_PC3_Human3.05258881
5IGF1R_20145208_ChIP-Seq_DFB_Human2.79745565
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.53824267
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.53379942
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.46087396
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.40242876
10FUS_26573619_Chip-Seq_HEK293_Human2.39569146
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.38983128
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.37865736
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.37714021
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.28038879
15ZNF274_21170338_ChIP-Seq_K562_Hela2.25129109
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.24258441
17* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.17523666
18EWS_26573619_Chip-Seq_HEK293_Human2.14273904
19EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.06518865
20P300_19829295_ChIP-Seq_ESCs_Human2.06467617
21PCGF2_27294783_Chip-Seq_ESCs_Mouse2.06313663
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.00435311
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.2580864
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.98921297
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93426884
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.83192995
27VDR_22108803_ChIP-Seq_LS180_Human1.82826105
28BCAT_22108803_ChIP-Seq_LS180_Human1.82100959
29UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.81441436
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.81356237
31GATA1_26923725_Chip-Seq_HPCs_Mouse1.78699666
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.77788110
33ELK4_26923725_Chip-Seq_MESODERM_Mouse1.76260033
34* ER_23166858_ChIP-Seq_MCF-7_Human1.74385166
35TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.70455139
36KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.70403985
37RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.69795308
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.67087046
39EST1_17652178_ChIP-ChIP_JURKAT_Human1.63060006
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.60852972
41CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.60067371
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.59773012
43RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59690859
44STAT1_17558387_ChIP-Seq_HELA_Human1.59227593
45KAP1_22055183_ChIP-Seq_ESCs_Mouse1.56094269
46WDR5_24793694_ChIP-Seq_LNCAP_Human1.54494535
47GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.54254088
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.52005066
49MYC_18940864_ChIP-ChIP_HL60_Human1.51992759
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51041969
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.47768032
52FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47713746
53AR_25329375_ChIP-Seq_VCAP_Human1.47073668
54SMAD4_21799915_ChIP-Seq_A2780_Human1.46073365
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45212796
56STAT3_23295773_ChIP-Seq_U87_Human1.44764081
57TAL1_26923725_Chip-Seq_HPCs_Mouse1.44535643
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42300221
59ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.42242052
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41801947
61CBP_20019798_ChIP-Seq_JUKART_Human1.41801947
62KDM2B_26808549_Chip-Seq_REH_Human1.40486315
63ELK1_19687146_ChIP-ChIP_HELA_Human1.39753661
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38274857
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36373219
66MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.35799141
67TCF4_23295773_ChIP-Seq_U87_Human1.35659440
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.34284236
69SOX2_22085726_ChIP-Seq_NPCs_Mouse1.34077977
70TP53_22573176_ChIP-Seq_HFKS_Human1.33216365
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33075502
72POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32850239
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.32478567
74GATA3_21867929_ChIP-Seq_CD8_Mouse1.31666345
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30797319
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29849720
77TCF4_22108803_ChIP-Seq_LS180_Human1.28620500
78GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28542860
79* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27815329
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27741882
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27431938
82NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.27148982
83NANOG_19829295_ChIP-Seq_ESCs_Human1.27116405
84SOX2_19829295_ChIP-Seq_ESCs_Human1.27116405
85FLI1_21867929_ChIP-Seq_TH2_Mouse1.24050567
86RUNX2_22187159_ChIP-Seq_PCA_Human1.23714293
87LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.22484118
88SMAD4_21741376_ChIP-Seq_EPCs_Human1.18847173
89REST_21632747_ChIP-Seq_MESCs_Mouse1.18056893
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.17898019
91CRX_20693478_ChIP-Seq_RETINA_Mouse1.17446402
92IRF1_19129219_ChIP-ChIP_H3396_Human1.16014084
93FOXA1_25329375_ChIP-Seq_VCAP_Human1.15724440
94FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15724440
95SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.15188076
96NANOG_18555785_Chip-Seq_ESCs_Mouse1.14533952
97BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13973920
98OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12913577
99SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.12834577
100MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12345304
101P53_21459846_ChIP-Seq_SAOS-2_Human1.12034089
102* GATA3_21867929_ChIP-Seq_TH1_Mouse1.11525620
103OCT4_18555785_Chip-Seq_ESCs_Mouse1.10345139
104EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09682291
105VDR_23849224_ChIP-Seq_CD4+_Human1.09595118
106TP63_19390658_ChIP-ChIP_HaCaT_Human1.09483178
107RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08894808
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08545152
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08545152
110RNF2_27304074_Chip-Seq_NSC_Mouse1.08544070
111PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08488028
112CDX2_22108803_ChIP-Seq_LS180_Human1.08074706
113ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07885625
114E2F4_17652178_ChIP-ChIP_JURKAT_Human1.07741796
115* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07728058
116CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07376237
117CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07357221
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06967917
119FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06574932
120GF1_26923725_Chip-Seq_HPCs_Mouse1.06230238
121CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05815783
122NCOR_22424771_ChIP-Seq_293T_Human1.05740386
123CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05390832
124EZH2_27294783_Chip-Seq_NPCs_Mouse1.05336921
125P53_22387025_ChIP-Seq_ESCs_Mouse1.04954925
126PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.04767058
127AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04764112
128RUNX1_26923725_Chip-Seq_HPCs_Mouse1.03810375
129PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02989607
130P300_18555785_Chip-Seq_ESCs_Mouse1.01833500
131RAD21_21589869_ChIP-Seq_MESCs_Mouse1.01116043
132PHF8_20622853_ChIP-Seq_HELA_Human1.01007772
133EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00479959
134ETV1_20927104_ChIP-Seq_GIST48_Human1.00463317
135OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99846242
136PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.99590225
137TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99376743
138KLF4_18555785_Chip-Seq_ESCs_Mouse0.99319639
139CMYC_18555785_Chip-Seq_ESCs_Mouse0.97811127
140TBL1_22424771_ChIP-Seq_293T_Human0.97501253
141PRDM14_20953172_ChIP-Seq_ESCs_Human0.97347284
142PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97286282
143EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.97265324
144AR_20517297_ChIP-Seq_VCAP_Human0.96649328
145ESRRB_18555785_Chip-Seq_ESCs_Mouse0.95715453
146ERG_20517297_ChIP-Seq_VCAP_Human0.95437746
147ESET_19884257_ChIP-Seq_ESCs_Mouse0.93397809
148STAT3_18555785_Chip-Seq_ESCs_Mouse0.92911351
149EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92456279
150CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.92316165
151SPI1_26923725_Chip-Seq_HPCs_Mouse0.91750925
152TAF15_26573619_Chip-Seq_HEK293_Human0.90977693
153SUZ12_18555785_Chip-Seq_ESCs_Mouse0.89860142
154PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88583344
155YY1_22570637_ChIP-Seq_MALME-3M_Human0.87447468
156RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.87122755
157SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86900411
158PU1_27457419_Chip-Seq_LIVER_Mouse0.86351004
159CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84954957
160SOX2_21211035_ChIP-Seq_LN229_Human0.84557543
161SOX9_26525672_Chip-Seq_HEART_Mouse0.84383507
162RARA_24833708_ChIP-Seq_LIVER_Mouse0.84250572
163FLI1_21867929_ChIP-Seq_CD8_Mouse0.83351009
164RUNX1_27457419_Chip-Seq_LIVER_Mouse0.83194508
165LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.83176239
166GF1B_26923725_Chip-Seq_HPCs_Mouse0.83032121
167MYC_27129775_Chip-Seq_CORNEA_Mouse0.81969832

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive6.10377731
2MP0001929_abnormal_gametogenesis5.72025325
3MP0008877_abnormal_DNA_methylation5.50547554
4MP0002210_abnormal_sex_determination3.92478788
5MP0006292_abnormal_olfactory_placode3.45998145
6MP0001145_abnormal_male_reproductive3.29965356
7* MP0002161_abnormal_fertility/fecundity3.29706142
8MP0002653_abnormal_ependyma_morphology3.24662086
9MP0000653_abnormal_sex_gland2.86833135
10MP0003718_maternal_effect2.77847484
11MP0002736_abnormal_nociception_after2.50901196
12MP0003195_calcinosis2.28925033
13MP0003787_abnormal_imprinting2.25453513
14MP0008789_abnormal_olfactory_epithelium2.24528237
15MP0005623_abnormal_meninges_morphology2.16259211
16MP0006276_abnormal_autonomic_nervous2.16169485
17MP0005646_abnormal_pituitary_gland2.02781815
18MP0001968_abnormal_touch/_nociception2.00686081
19* MP0005410_abnormal_fertilization15.2254279
20MP0002160_abnormal_reproductive_system1.99503497
21MP0000372_irregular_coat_pigmentation1.92083699
22MP0005499_abnormal_olfactory_system1.90063020
23MP0005394_taste/olfaction_phenotype1.90063020
24MP0008057_abnormal_DNA_replication1.86356573
25MP0005670_abnormal_white_adipose1.86098960
26MP0001529_abnormal_vocalization1.75621219
27MP0002837_dystrophic_cardiac_calcinosis1.64650027
28MP0000631_abnormal_neuroendocrine_gland1.59915315
29MP0001986_abnormal_taste_sensitivity1.50180658
30MP0003121_genomic_imprinting1.49256419
31MP0003890_abnormal_embryonic-extraembry1.48925444
32MP0002282_abnormal_trachea_morphology1.46664498
33MP0002938_white_spotting1.45343312
34MP0003646_muscle_fatigue1.41519014
35MP0009745_abnormal_behavioral_response1.40389305
36MP0008872_abnormal_physiological_respon1.38053329
37MP0001501_abnormal_sleep_pattern1.36902534
38MP0003136_yellow_coat_color1.35630555
39MP0008058_abnormal_DNA_repair1.34022589
40MP0002638_abnormal_pupillary_reflex1.33230672
41MP0002272_abnormal_nervous_system1.32398048
42MP0001486_abnormal_startle_reflex1.31830517
43MP0008875_abnormal_xenobiotic_pharmacok1.31799657
44MP0002254_reproductive_system_inflammat1.29763624
45MP0003880_abnormal_central_pattern1.29056065
46MP0002277_abnormal_respiratory_mucosa1.23449153
47MP0004142_abnormal_muscle_tone1.21690729
48MP0009046_muscle_twitch1.19182694
49MP0002735_abnormal_chemical_nociception1.19126392
50MP0004233_abnormal_muscle_weight1.18642305
51MP0003693_abnormal_embryo_hatching1.18142098
52MP0002163_abnormal_gland_morphology1.15964393
53MP0010094_abnormal_chromosome_stability1.15055244
54MP0010386_abnormal_urinary_bladder1.12473424
55MP0008995_early_reproductive_senescence1.12319807
56MP0010030_abnormal_orbit_morphology1.07080807
57MP0005395_other_phenotype1.07058187
58MP0001765_abnormal_ion_homeostasis1.06866481
59MP0001984_abnormal_olfaction1.04321189
60MP0002233_abnormal_nose_morphology1.02575410
61MP0005389_reproductive_system_phenotype1.02105709
62MP0003252_abnormal_bile_duct1.01965910
63MP0002734_abnormal_mechanical_nocicepti0.96879538
64MP0005187_abnormal_penis_morphology0.95868758
65MP0002557_abnormal_social/conspecific_i0.95846626
66MP0001485_abnormal_pinna_reflex0.95514733
67MP0004215_abnormal_myocardial_fiber0.95207571
68MP0003119_abnormal_digestive_system0.94768192
69MP0003011_delayed_dark_adaptation0.92874617
70MP0002572_abnormal_emotion/affect_behav0.92486274
71MP0002138_abnormal_hepatobiliary_system0.92452093
72MP0004043_abnormal_pH_regulation0.91744147
73MP0003786_premature_aging0.91351897
74MP0008007_abnormal_cellular_replicative0.88130581
75MP0003937_abnormal_limbs/digits/tail_de0.88103584
76MP0005645_abnormal_hypothalamus_physiol0.87805774
77MP0000049_abnormal_middle_ear0.86719142
78MP0002751_abnormal_autonomic_nervous0.86643049
79MP0002752_abnormal_somatic_nervous0.86125550
80MP0004924_abnormal_behavior0.85758312
81MP0005386_behavior/neurological_phenoty0.85758312
82MP0003567_abnormal_fetal_cardiomyocyte0.85400209
83MP0003938_abnormal_ear_development0.84541860
84MP0005084_abnormal_gallbladder_morpholo0.83891376
85MP0002064_seizures0.82237546
86MP0004885_abnormal_endolymph0.78527843
87MP0000383_abnormal_hair_follicle0.78273574
88MP0000778_abnormal_nervous_system0.77566970
89MP0003186_abnormal_redox_activity0.77280814
90MP0000569_abnormal_digit_pigmentation0.76484079
91MP0001970_abnormal_pain_threshold0.76288989
92MP0005379_endocrine/exocrine_gland_phen0.75319234
93MP0005377_hearing/vestibular/ear_phenot0.67525455
94MP0003878_abnormal_ear_physiology0.67525455
95MP0003950_abnormal_plasma_membrane0.64445104
96MP0000358_abnormal_cell_content/0.64262799
97MP0001545_abnormal_hematopoietic_system0.58303740
98MP0005397_hematopoietic_system_phenotyp0.58303740
99MP0003115_abnormal_respiratory_system0.58061503
100MP0002234_abnormal_pharynx_morphology0.57829854
101MP0004134_abnormal_chest_morphology0.56844217
102MP0002928_abnormal_bile_duct0.55655063
103MP0005636_abnormal_mineral_homeostasis0.53973767
104MP0003111_abnormal_nucleus_morphology0.53926276
105MP0003699_abnormal_female_reproductive0.53675837
106MP0010307_abnormal_tumor_latency0.51705533
107MP0004808_abnormal_hematopoietic_stem0.51472467
108MP0009278_abnormal_bone_marrow0.47887684
109MP0001119_abnormal_female_reproductive0.46236115
110MP0004036_abnormal_muscle_relaxation0.44273334
111MP0001324_abnormal_eye_pigmentation0.43842561
112MP0001293_anophthalmia0.43836070
113MP0003329_amyloid_beta_deposits0.42152892
114MP0005253_abnormal_eye_physiology0.40785574
115MP0005551_abnormal_eye_electrophysiolog0.40739488
116MP0005666_abnormal_adipose_tissue0.40500152
117MP0001730_embryonic_growth_arrest0.40479686
118MP0004019_abnormal_vitamin_homeostasis0.37526958
119MP0002269_muscular_atrophy0.34739774
120MP0005391_vision/eye_phenotype0.34576595
121MP0001727_abnormal_embryo_implantation0.33617306
122MP0002102_abnormal_ear_morphology0.33437086
123MP0001764_abnormal_homeostasis0.33192339
124MP0006036_abnormal_mitochondrial_physio0.32863804
125MP0002971_abnormal_brown_adipose0.31753433
126MP0003077_abnormal_cell_cycle0.31125790
127MP0000313_abnormal_cell_death0.29412910
128MP0009115_abnormal_fat_cell0.27434597
129MP0000427_abnormal_hair_cycle0.27131968
130MP0003633_abnormal_nervous_system0.26468963
131MP0003861_abnormal_nervous_system0.26057435
132MP0001661_extended_life_span0.24877656
133MP0002084_abnormal_developmental_patter0.24060047
134MP0003879_abnormal_hair_cell0.23762744
135MP0004811_abnormal_neuron_physiology0.23702233
136MP0002152_abnormal_brain_morphology0.23531571
137MP0004133_heterotaxia0.22671029
138MP0008961_abnormal_basal_metabolism0.21974256
139MP0003045_fibrosis0.21745505
140MP0000751_myopathy0.21628234
141MP0002092_abnormal_eye_morphology0.21431892
142MP0001851_eye_inflammation0.20673023
143MP0002139_abnormal_hepatobiliary_system0.20238092
144MP0003631_nervous_system_phenotype0.19543545
145MP0000604_amyloidosis0.19323290
146MP0006035_abnormal_mitochondrial_morpho0.18981044
147MP0006072_abnormal_retinal_apoptosis0.17648923
148MP0005380_embryogenesis_phenotype0.17193757
149MP0001672_abnormal_embryogenesis/_devel0.17193757
150MP0001697_abnormal_embryo_size0.16375370
151MP0000534_abnormal_ureter_morphology0.16277267
152MP0003942_abnormal_urinary_system0.15562035
153MP0002169_no_abnormal_phenotype0.14873356
154MP0002229_neurodegeneration0.14771012
155MP0002873_normal_phenotype0.14624226
156MP0000647_abnormal_sebaceous_gland0.13805139
157MP0002405_respiratory_system_inflammati0.13410676
158MP0002080_prenatal_lethality0.13347062
159MP0002108_abnormal_muscle_morphology0.12599564
160MP0003936_abnormal_reproductive_system0.12508794
161MP0002970_abnormal_white_adipose0.12445070
162MP0005195_abnormal_posterior_eye0.12319571
163MP0003948_abnormal_gas_homeostasis0.12259497
164MP0006138_congestive_heart_failure0.12221293
165MP0005365_abnormal_bile_salt0.12194439

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.49895061
2Abnormal respiratory epithelium morphology (HP:0012253)8.99454996
3Abnormal respiratory motile cilium morphology (HP:0005938)8.99454996
4Rhinitis (HP:0012384)7.96277024
5Abnormal ciliary motility (HP:0012262)7.72636616
6Chronic bronchitis (HP:0004469)7.38859124
7Nasal polyposis (HP:0100582)6.41363351
8Infertility (HP:0000789)6.33626787
9Abnormality of the nasal mucosa (HP:0000433)5.27138612
10Bronchiectasis (HP:0002110)4.61062206
11Bronchitis (HP:0012387)4.54477371
12Nephronophthisis (HP:0000090)4.49951480
13Abnormality of the labia minora (HP:0012880)3.95385465
14Pancreatic cysts (HP:0001737)3.86135067
15True hermaphroditism (HP:0010459)3.69370212
16Male infertility (HP:0003251)3.62002051
17Recurrent sinusitis (HP:0011108)3.52864750
18Abnormality of the renal medulla (HP:0100957)3.43640020
19Abnormality of the lower motor neuron (HP:0002366)3.41222615
20Recurrent otitis media (HP:0000403)3.32165552
21Abnormal spermatogenesis (HP:0008669)3.08744836
22Pendular nystagmus (HP:0012043)3.04286185
23Tubulointerstitial nephritis (HP:0001970)2.98298408
24Gonadotropin excess (HP:0000837)2.95385881
25Chromsome breakage (HP:0040012)2.83444757
26Progressive cerebellar ataxia (HP:0002073)2.69995616
27Abnormality of midbrain morphology (HP:0002418)2.68134540
28Molar tooth sign on MRI (HP:0002419)2.68134540
29Amyotrophic lateral sclerosis (HP:0007354)2.65278712
30Recurrent bronchitis (HP:0002837)2.64889537
31Medial flaring of the eyebrow (HP:0010747)2.64854841
32Congenital stationary night blindness (HP:0007642)2.63430052
33Tubular atrophy (HP:0000092)2.62711059
34Chromosomal breakage induced by crosslinking agents (HP:0003221)2.51591311
35Tubulointerstitial abnormality (HP:0001969)2.50000613
36Fibular hypoplasia (HP:0003038)2.49861280
37Volvulus (HP:0002580)2.43479761
38Gaze-evoked nystagmus (HP:0000640)2.41953247
39Acute necrotizing encephalopathy (HP:0006965)2.40386051
40Severe visual impairment (HP:0001141)2.40366975
41Abolished electroretinogram (ERG) (HP:0000550)2.32692004
42Male pseudohermaphroditism (HP:0000037)2.30259056
43Azoospermia (HP:0000027)2.29584035
44Acute encephalopathy (HP:0006846)2.29462926
45Attenuation of retinal blood vessels (HP:0007843)2.27486720
46Absent rod-and cone-mediated responses on ERG (HP:0007688)2.27088880
47Anencephaly (HP:0002323)2.26520420
48Oligodactyly (hands) (HP:0001180)2.25251060
49Aplasia/Hypoplasia of the uvula (HP:0010293)2.25054912
50Optic nerve hypoplasia (HP:0000609)2.24641307
513-Methylglutaconic aciduria (HP:0003535)2.23743127
52Impulsivity (HP:0100710)2.23713336
53Intestinal atresia (HP:0011100)2.22357354
54Abnormal rod and cone electroretinograms (HP:0008323)2.21139385
55Hyperglycinemia (HP:0002154)2.19312349
56Progressive macrocephaly (HP:0004481)2.17153379
57Aplasia/Hypoplasia of the tibia (HP:0005772)2.16527033
58Sclerocornea (HP:0000647)2.14477196
59Genetic anticipation (HP:0003743)2.14322423
60Meckel diverticulum (HP:0002245)2.12219025
61Abnormality of the ileum (HP:0001549)2.10965168
62Postaxial foot polydactyly (HP:0001830)2.09403075
63Abnormality of chromosome stability (HP:0003220)2.07193798
64Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.06669597
65Septo-optic dysplasia (HP:0100842)2.06257139
66Impaired proprioception (HP:0010831)2.05866841
67Methylmalonic acidemia (HP:0002912)2.03313745
68Chronic hepatic failure (HP:0100626)2.02867564
69Genital tract atresia (HP:0001827)2.02430292
70Preaxial hand polydactyly (HP:0001177)2.01231818
71Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.6166696
72Dynein arm defect of respiratory motile cilia (HP:0012255)12.9429884
73Absent/shortened dynein arms (HP:0200106)12.9429884
74Stage 5 chronic kidney disease (HP:0003774)1.99224628
75Increased CSF lactate (HP:0002490)1.98520709
76Short tibia (HP:0005736)1.98101827
77Mitochondrial inheritance (HP:0001427)1.97299884
78Tubulointerstitial fibrosis (HP:0005576)1.97049660
79Hypoplasia of the capital femoral epiphysis (HP:0003090)1.95505892
80Hypoplasia of the uterus (HP:0000013)1.94931701
81Upper motor neuron abnormality (HP:0002127)1.93945168
82Abnormal mitochondria in muscle tissue (HP:0008316)1.93577717
83Febrile seizures (HP:0002373)1.93351883
84Hyperventilation (HP:0002883)1.93140109
85Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.92372046
86Abnormality of alanine metabolism (HP:0010916)1.92372046
87Hyperalaninemia (HP:0003348)1.92372046
88Aplasia/hypoplasia of the uterus (HP:0008684)1.91822495
89Focal seizures (HP:0007359)1.91057760
90Vaginal atresia (HP:0000148)1.90237283
91Renal cortical cysts (HP:0000803)1.89905846
92Absent frontal sinuses (HP:0002688)1.89529292
93Congenital hepatic fibrosis (HP:0002612)1.88877904
94Facial hemangioma (HP:0000329)1.87341006
95Abnormality of the renal cortex (HP:0011035)1.86772768
96Dialeptic seizures (HP:0011146)1.86509342
97Colon cancer (HP:0003003)1.85734213
98Hepatoblastoma (HP:0002884)1.84261371
99Type II lissencephaly (HP:0007260)1.84211870
100Bony spicule pigmentary retinopathy (HP:0007737)1.83192659
101Gastrointestinal atresia (HP:0002589)1.83132864
102Short ribs (HP:0000773)1.82744592
103Methylmalonic aciduria (HP:0012120)1.80707437
104Progressive inability to walk (HP:0002505)1.80515156
105Microglossia (HP:0000171)1.80220521
106Abnormal drinking behavior (HP:0030082)1.79532950
107Polydipsia (HP:0001959)1.79532950
108J-shaped sella turcica (HP:0002680)1.78437235
109Degeneration of anterior horn cells (HP:0002398)1.78155330
110Abnormality of the anterior horn cell (HP:0006802)1.78155330
111Oculomotor apraxia (HP:0000657)1.77969655
112Broad-based gait (HP:0002136)1.76673174
113Focal motor seizures (HP:0011153)1.75714032
114Oligodactyly (HP:0012165)1.75707727
115Taurodontia (HP:0000679)1.75544587
116Abnormality of permanent molar morphology (HP:0011071)1.75544587
117Abnormality of the dental root (HP:0006486)1.75544587
118Aplasia/Hypoplasia of the fovea (HP:0008060)1.75328860
119Hypoplasia of the fovea (HP:0007750)1.75328860
120Abnormality of macular pigmentation (HP:0008002)1.73486925
121Abnormality of dentin (HP:0010299)1.72060488
122Ectopic kidney (HP:0000086)1.70329597
123Chronic sinusitis (HP:0011109)1.70101676
124Congenital sensorineural hearing impairment (HP:0008527)1.69364849
125Sloping forehead (HP:0000340)1.69284047
126Renal dysplasia (HP:0000110)1.67671004
127Supernumerary spleens (HP:0009799)1.66086313
128Spastic tetraparesis (HP:0001285)1.64033783
129Abnormality of molar morphology (HP:0011070)1.63608037
130Abnormality of molar (HP:0011077)1.63608037
131Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.62368045
132Postaxial hand polydactyly (HP:0001162)1.60490462
133Facial cleft (HP:0002006)1.60023571
134Abnormality of the dental pulp (HP:0006479)1.58951485
135Heterotopia (HP:0002282)1.58546097
136Abnormality of renal excretion (HP:0011036)1.58262532
137Cholecystitis (HP:0001082)1.56572389
138Abnormal gallbladder physiology (HP:0012438)1.56572389
139Aplasia/Hypoplasia of the fibula (HP:0006492)1.55736522
140Absent epiphyses (HP:0010577)1.54022682
141Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.54022682
14211 pairs of ribs (HP:0000878)1.53125625
143Congenital primary aphakia (HP:0007707)1.48774158
144Gait imbalance (HP:0002141)1.48238943
145Bell-shaped thorax (HP:0001591)1.48236552
146Aplasia/Hypoplasia of the tongue (HP:0010295)1.45059409
147Median cleft lip (HP:0000161)1.43451197
148Dyschromatopsia (HP:0007641)1.43411339
149Cystic liver disease (HP:0006706)1.42902381
150Deformed sella turcica (HP:0002681)1.42735300
151Abnormal biliary tract physiology (HP:0012439)1.42071970
152Bile duct proliferation (HP:0001408)1.42071970
153Short thorax (HP:0010306)1.40200081
154Pancreatic fibrosis (HP:0100732)1.37811957
155Breast carcinoma (HP:0003002)1.36883031
156Abnormality of ocular smooth pursuit (HP:0000617)1.33664253
157Broad distal phalanx of finger (HP:0009836)1.33150142
158Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.32471891
159Nephropathy (HP:0000112)1.29902299
160Aplasia/Hypoplasia of the lens (HP:0008063)1.26728235
161Nephrogenic diabetes insipidus (HP:0009806)1.26020693
162Decreased central vision (HP:0007663)1.25383151
163Conjunctival telangiectasia (HP:0000524)1.24462869
164Pachygyria (HP:0001302)1.23464805
165Abnormal urine output (HP:0012590)1.22410433
166Hypoplasia of dental enamel (HP:0006297)1.20171314
167Selective tooth agenesis (HP:0001592)1.18950552
168Decreased motor nerve conduction velocity (HP:0003431)1.16672182
169Cerebellar dysplasia (HP:0007033)1.16039914
170Abnormality of saccadic eye movements (HP:0000570)1.14596243

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK39.27803949
2PDK49.27803949
3PDK26.02975793
4TESK14.33166243
5FRK4.20747410
6ACVR1B4.05064337
7PRKD33.60859948
8ICK3.19474245
9MAP4K23.12060359
10MST42.48270511
11PNCK2.46227554
12PTK2B2.42659185
13ZAK2.35269599
14WNK42.32547918
15STK392.22628021
16NUAK12.17412440
17TRIM282.15235008
18MAPK132.12229336
19GRK12.09908118
20OXSR11.87410029
21TNIK1.83951272
22NEK21.80280511
23CASK1.76538786
24ADRBK21.66690221
25CDK191.60854362
26INSRR1.53392801
27PAK31.35037688
28STK381.28128529
29MKNK21.23099169
30EPHA41.18597038
31BCR1.16528012
32VRK11.10091967
33PLK21.09029102
34PRKCI1.08284357
35DYRK21.05744859
36WNK11.03714265
37NEK11.03679113
38CSNK1G11.00352345
39MAPK150.99059130
40PLK30.97054992
41DYRK1B0.96043916
42TYRO30.95744051
43TAOK30.95594210
44PDK10.92248891
45CSNK1G20.91016966
46STK160.90994802
47BCKDK0.90656473
48BUB10.89482197
49SRPK10.88452338
50ERBB30.86740693
51CCNB10.84857048
52STK30.83536973
53CDC70.83535044
54PASK0.82633822
55CSNK1G30.80768562
56EIF2AK30.78538894
57PBK0.78303790
58PRKCE0.78275228
59FGFR20.76702120
60STK240.74632131
61VRK20.73876379
62CSNK1A1L0.72021784
63DYRK30.69525606
64LATS10.69127218
65WEE10.68075037
66TTK0.66292846
67TAF10.64304953
68MKNK10.63508265
69TGFBR10.61542066
70IRAK10.61417878
71TEC0.58192936
72CAMK1G0.58036876
73LMTK20.56054169
74CAMK2A0.54822519
75MARK10.54436866
76TNK20.53603844
77TXK0.52343950
78PINK10.52002717
79CHEK20.51290003
80CHEK10.51015781
81ATR0.47733539
82NME10.46901388
83CSNK1A10.45183310
84AURKA0.44002061
85PLK40.43590792
86TESK20.43060153
87ADRBK10.41916152
88PRKACA0.40919540
89FER0.40534205
90MAPKAPK30.39353489
91AURKB0.38863415
92MAP2K60.38008736
93ATM0.35699897
94DYRK1A0.35454042
95MINK10.35232404
96PDPK10.33834172
97CAMK10.33540831
98EEF2K0.32991138
99STK38L0.32963480
100FLT30.32929543
101NTRK30.32390972
102CDK120.31621147
103PAK10.28619867
104MTOR0.28473963
105NTRK20.25106740
106PLK10.24510350
107PAK20.23558878
108PRKCG0.21633037
109CAMKK10.21005458
110IRAK20.20367695
111BMPR1B0.20336218
112PRKAA10.19221851
113MUSK0.19074387
114RPS6KB10.18205945
115RIPK40.18023931
116BRSK20.17754305
117NEK60.15318300
118MAPKAPK50.13510919
119MARK20.12840404
120WNK30.11549553
121MAP3K40.07868712
122CSNK1D0.07729801
123CDK10.06280001
124CSNK2A10.05794805
125MARK30.05665952
126BRAF0.05642946
127CDK20.05521111
128PRKCQ0.04881091
129PRKG10.04531861
130PRKCZ0.04441468
131GSK3B0.04413017
132MAP3K100.04221940
133PRKACG0.04157488
134PRKDC0.03891665
135CDK150.03217116
136PAK40.03006426
137MAPK80.02927946
138BRSK10.02647232
139STK100.02342910
140CSNK2A20.01989052
141ZAP700.01873943
142PRKACB0.01863936
143PAK60.01376110
144RPS6KA10.01305247
145STK110.01104705
146CDK180.01095754
147CDK11A0.00501140
148PDGFRB0.00201625
149EGFR0.00140218
150PRKCA-0.0376501
151PKN1-0.0367104
152MAPK1-0.0323719
153PRKG2-0.0297044
154CDK6-0.0287003
155MAPK10-0.0255846
156CDK4-0.0189276
157CDK14-0.0171530
158MAP2K7-0.0166143
159RIPK1-0.0157842
160RPS6KA3-0.0137747
161CSF1R-0.0083661
162CDK3-0.0063304
163PRKCB-0.0015342

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.40380906
2* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.71369850
3Fatty acid biosynthesis_Homo sapiens_hsa000613.40996652
4* Pyruvate metabolism_Homo sapiens_hsa006203.13238237
5Basal transcription factors_Homo sapiens_hsa030222.92720429
6Selenocompound metabolism_Homo sapiens_hsa004502.79572356
7Pentose phosphate pathway_Homo sapiens_hsa000302.73808563
8Dorso-ventral axis formation_Homo sapiens_hsa043202.58126704
9Protein export_Homo sapiens_hsa030602.55651062
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.52910692
11* Glucagon signaling pathway_Homo sapiens_hsa049222.49399980
12Fanconi anemia pathway_Homo sapiens_hsa034602.46175800
13Non-homologous end-joining_Homo sapiens_hsa034502.44736663
14Linoleic acid metabolism_Homo sapiens_hsa005912.42737347
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.38550744
16Mismatch repair_Homo sapiens_hsa034302.36954418
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.36726265
18RNA polymerase_Homo sapiens_hsa030202.33672403
19Oocyte meiosis_Homo sapiens_hsa041142.21731204
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.11835271
21Phototransduction_Homo sapiens_hsa047442.10903232
22Glycerolipid metabolism_Homo sapiens_hsa005612.08799702
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.98632427
24Oxidative phosphorylation_Homo sapiens_hsa001901.93112743
25Huntingtons disease_Homo sapiens_hsa050161.87419899
26Carbohydrate digestion and absorption_Homo sapiens_hsa049731.83570797
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.83287308
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.79876232
29* Propanoate metabolism_Homo sapiens_hsa006401.78049468
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.76839973
31PPAR signaling pathway_Homo sapiens_hsa033201.75225835
32Butanoate metabolism_Homo sapiens_hsa006501.71879686
33Caffeine metabolism_Homo sapiens_hsa002321.71159306
34Olfactory transduction_Homo sapiens_hsa047401.68314222
35Amphetamine addiction_Homo sapiens_hsa050311.67807504
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.63083602
37Carbon metabolism_Homo sapiens_hsa012001.62294990
38DNA replication_Homo sapiens_hsa030301.59176940
39Fatty acid elongation_Homo sapiens_hsa000621.56197182
40Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.53073525
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.51678525
42Nucleotide excision repair_Homo sapiens_hsa034201.51204942
43Parkinsons disease_Homo sapiens_hsa050121.50897322
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.50595158
45mRNA surveillance pathway_Homo sapiens_hsa030151.48879347
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.46062941
47Fructose and mannose metabolism_Homo sapiens_hsa000511.45752341
48Tryptophan metabolism_Homo sapiens_hsa003801.45525247
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44891977
50Renin secretion_Homo sapiens_hsa049241.42666150
51Proteasome_Homo sapiens_hsa030501.41188120
52RNA transport_Homo sapiens_hsa030131.39528177
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39445356
54Nitrogen metabolism_Homo sapiens_hsa009101.39160047
55Glycerophospholipid metabolism_Homo sapiens_hsa005641.38674408
56Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.38105634
57Nicotine addiction_Homo sapiens_hsa050331.37563242
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.37353293
59Cardiac muscle contraction_Homo sapiens_hsa042601.31789921
60Antigen processing and presentation_Homo sapiens_hsa046121.31503525
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.23951502
62Base excision repair_Homo sapiens_hsa034101.22837634
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21325953
64Steroid hormone biosynthesis_Homo sapiens_hsa001401.18118628
65Maturity onset diabetes of the young_Homo sapiens_hsa049501.17444588
66Biosynthesis of amino acids_Homo sapiens_hsa012301.12873482
67Fat digestion and absorption_Homo sapiens_hsa049751.11635395
68One carbon pool by folate_Homo sapiens_hsa006701.11038646
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08993750
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.08964489
71Sulfur relay system_Homo sapiens_hsa041221.07894231
72Purine metabolism_Homo sapiens_hsa002301.06643272
73Fatty acid metabolism_Homo sapiens_hsa012121.06405343
74Ether lipid metabolism_Homo sapiens_hsa005651.05631345
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05611268
76Mineral absorption_Homo sapiens_hsa049781.04871606
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04023224
78Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.03694023
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01449343
80Fatty acid degradation_Homo sapiens_hsa000710.98860108
81Long-term potentiation_Homo sapiens_hsa047200.93052204
82Regulation of autophagy_Homo sapiens_hsa041400.92644349
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92095639
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92086881
85Peroxisome_Homo sapiens_hsa041460.91698861
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85579637
87ABC transporters_Homo sapiens_hsa020100.84580819
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79802160
89Estrogen signaling pathway_Homo sapiens_hsa049150.76011836
90Glutathione metabolism_Homo sapiens_hsa004800.75850298
91Morphine addiction_Homo sapiens_hsa050320.75828630
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75688788
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.74736885
94Circadian rhythm_Homo sapiens_hsa047100.74588116
95Steroid biosynthesis_Homo sapiens_hsa001000.74406987
96Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72204048
97Alzheimers disease_Homo sapiens_hsa050100.71449437
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70136115
99beta-Alanine metabolism_Homo sapiens_hsa004100.69827695
100Chemical carcinogenesis_Homo sapiens_hsa052040.66482350
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64538816
102Calcium signaling pathway_Homo sapiens_hsa040200.62414803
103Folate biosynthesis_Homo sapiens_hsa007900.60749216
104Legionellosis_Homo sapiens_hsa051340.59049710
105Serotonergic synapse_Homo sapiens_hsa047260.59036462
106N-Glycan biosynthesis_Homo sapiens_hsa005100.57987974
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57255782
108Collecting duct acid secretion_Homo sapiens_hsa049660.56962893
109VEGF signaling pathway_Homo sapiens_hsa043700.56624957
110Renin-angiotensin system_Homo sapiens_hsa046140.55825290
111Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55153032
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.53812007
113Arginine and proline metabolism_Homo sapiens_hsa003300.53614335
114Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53527907
115Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51054826
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50902122
117AMPK signaling pathway_Homo sapiens_hsa041520.48910345
118Insulin secretion_Homo sapiens_hsa049110.48553696
119Inositol phosphate metabolism_Homo sapiens_hsa005620.48031807
120Arachidonic acid metabolism_Homo sapiens_hsa005900.47693078
121Bile secretion_Homo sapiens_hsa049760.46778258
122Thyroid hormone synthesis_Homo sapiens_hsa049180.45594979
123Hedgehog signaling pathway_Homo sapiens_hsa043400.45375385
124p53 signaling pathway_Homo sapiens_hsa041150.44369273
125Endocytosis_Homo sapiens_hsa041440.44223395
126Systemic lupus erythematosus_Homo sapiens_hsa053220.44198726
127Drug metabolism - other enzymes_Homo sapiens_hsa009830.43944169
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42890560
129GABAergic synapse_Homo sapiens_hsa047270.42536054
130Spliceosome_Homo sapiens_hsa030400.42355234
131TGF-beta signaling pathway_Homo sapiens_hsa043500.40719495
132Sulfur metabolism_Homo sapiens_hsa009200.38798218
133Homologous recombination_Homo sapiens_hsa034400.37177203
134* Cysteine and methionine metabolism_Homo sapiens_hsa002700.37154782
135Vitamin digestion and absorption_Homo sapiens_hsa049770.37148811
136RNA degradation_Homo sapiens_hsa030180.35360434
137* Metabolic pathways_Homo sapiens_hsa011000.34385669
138Taste transduction_Homo sapiens_hsa047420.33692639
139Cell cycle_Homo sapiens_hsa041100.30576891
140Protein digestion and absorption_Homo sapiens_hsa049740.29278172
141Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28792328
142Synaptic vesicle cycle_Homo sapiens_hsa047210.28383845
143B cell receptor signaling pathway_Homo sapiens_hsa046620.27652397
144Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.26919244
145Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26346713
146Circadian entrainment_Homo sapiens_hsa047130.26026323
147Pancreatic secretion_Homo sapiens_hsa049720.25794529
148Pyrimidine metabolism_Homo sapiens_hsa002400.25164401
149Vascular smooth muscle contraction_Homo sapiens_hsa042700.24827559
150Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.22487261
151cAMP signaling pathway_Homo sapiens_hsa040240.21842927
152Salivary secretion_Homo sapiens_hsa049700.20823515
153Wnt signaling pathway_Homo sapiens_hsa043100.20236098
154Viral carcinogenesis_Homo sapiens_hsa052030.19919616
155Gastric acid secretion_Homo sapiens_hsa049710.19322167
156Retinol metabolism_Homo sapiens_hsa008300.17820459
157Alcoholism_Homo sapiens_hsa050340.13519828
158Salmonella infection_Homo sapiens_hsa051320.10367530
159Glutamatergic synapse_Homo sapiens_hsa047240.08898836

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