LDHD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. The similar protein in yeast has both D-lactate and D-glycerate dehydrogenase activities. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.09799997
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.09799997
3L-phenylalanine metabolic process (GO:0006558)6.87861389
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.87861389
5glyoxylate metabolic process (GO:0046487)6.65416986
6aromatic amino acid family catabolic process (GO:0009074)6.64411981
7lysine catabolic process (GO:0006554)6.56740922
8lysine metabolic process (GO:0006553)6.56740922
9urate metabolic process (GO:0046415)6.50361956
10drug transmembrane transport (GO:0006855)6.50048074
11cysteine metabolic process (GO:0006534)6.48142928
12indolalkylamine catabolic process (GO:0046218)6.25236951
13tryptophan catabolic process (GO:0006569)6.25236951
14indole-containing compound catabolic process (GO:0042436)6.25236951
15actin-myosin filament sliding (GO:0033275)6.17955435
16muscle filament sliding (GO:0030049)6.17955435
17tryptophan metabolic process (GO:0006568)5.89882259
18creatine metabolic process (GO:0006600)5.72944040
19kynurenine metabolic process (GO:0070189)5.70265266
20sarcoplasmic reticulum calcium ion transport (GO:0070296)5.58107520
21fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.58015600
22NADH metabolic process (GO:0006734)5.48116872
23drug transport (GO:0015893)5.38027820
24serine family amino acid catabolic process (GO:0009071)5.33547932
25drug catabolic process (GO:0042737)5.30431832
26bile acid biosynthetic process (GO:0006699)5.18768559
27exogenous drug catabolic process (GO:0042738)5.14714259
28sulfur amino acid catabolic process (GO:0000098)5.09733790
29homocysteine metabolic process (GO:0050667)5.07970069
30amino-acid betaine metabolic process (GO:0006577)4.98399187
31actin-mediated cell contraction (GO:0070252)4.97132969
32skeletal muscle contraction (GO:0003009)4.95512561
33epoxygenase P450 pathway (GO:0019373)4.89225025
34aromatic amino acid family metabolic process (GO:0009072)4.85939610
35short-chain fatty acid metabolic process (GO:0046459)4.84009314
36oxaloacetate metabolic process (GO:0006107)4.72763891
37aspartate family amino acid catabolic process (GO:0009068)4.71328277
38cellular ketone body metabolic process (GO:0046950)4.70350982
39alpha-amino acid catabolic process (GO:1901606)4.67239871
40cellular modified amino acid catabolic process (GO:0042219)4.66785304
41serine family amino acid metabolic process (GO:0009069)4.66658656
42alpha-linolenic acid metabolic process (GO:0036109)4.55108760
43ethanol metabolic process (GO:0006067)4.49493376
44cellular amino acid catabolic process (GO:0009063)4.48772572
45regulation of skeletal muscle contraction (GO:0014819)4.47738476
46indolalkylamine metabolic process (GO:0006586)4.45888349
47organic cation transport (GO:0015695)4.45510959
48glutamate metabolic process (GO:0006536)4.43155616
49urea cycle (GO:0000050)4.37856113
50urea metabolic process (GO:0019627)4.37856113
51acetyl-CoA metabolic process (GO:0006084)4.35550051
52valine metabolic process (GO:0006573)4.32672100
532-oxoglutarate metabolic process (GO:0006103)4.32420157
54fatty acid beta-oxidation (GO:0006635)4.29410917
55bile acid metabolic process (GO:0008206)4.27329325
56response to mercury ion (GO:0046689)4.26241676
57cellular biogenic amine catabolic process (GO:0042402)4.25663194
58amine catabolic process (GO:0009310)4.25663194
59omega-hydroxylase P450 pathway (GO:0097267)4.25133792
60benzene-containing compound metabolic process (GO:0042537)4.24771720
61striated muscle contraction (GO:0006941)4.21502950
62branched-chain amino acid metabolic process (GO:0009081)4.20403224
63tyrosine metabolic process (GO:0006570)4.19751160
64phosphate ion transport (GO:0006817)4.17712762
65fatty acid oxidation (GO:0019395)4.14977065
66serine family amino acid biosynthetic process (GO:0009070)4.14740945
67nitrogen cycle metabolic process (GO:0071941)4.11716540
68triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.10018409
69sarcomere organization (GO:0045214)4.09399904
70lipid oxidation (GO:0034440)4.07454673
71ketone body metabolic process (GO:1902224)4.06090690
72myofibril assembly (GO:0030239)4.05261355
73positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.04236968
74carboxylic acid catabolic process (GO:0046395)4.03447040
75organic acid catabolic process (GO:0016054)4.03447040
76quaternary ammonium group transport (GO:0015697)4.03071100
77coenzyme catabolic process (GO:0009109)4.02333129
78cellular glucuronidation (GO:0052695)4.01408928
79carnitine metabolic process (GO:0009437)3.99510943
80complement activation, alternative pathway (GO:0006957)3.99152560
81response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.98655205
82aminoglycoside antibiotic metabolic process (GO:0030647)3.98433253
83regulation of relaxation of muscle (GO:1901077)3.98378816
84ethanol oxidation (GO:0006069)3.97110203
85branched-chain amino acid catabolic process (GO:0009083)3.95582588
86fatty acid catabolic process (GO:0009062)3.92825093
87tricarboxylic acid metabolic process (GO:0072350)3.90577544
88protein carboxylation (GO:0018214)3.89996844
89peptidyl-glutamic acid carboxylation (GO:0017187)3.89996844
90cardiac muscle contraction (GO:0060048)3.88794138
91monocarboxylic acid catabolic process (GO:0072329)3.87958677
92aldehyde catabolic process (GO:0046185)3.87114663
93dicarboxylic acid biosynthetic process (GO:0043650)3.87096999
94phosphate ion transmembrane transport (GO:0035435)3.86613233
95carnitine shuttle (GO:0006853)3.83575270
96glucuronate metabolic process (GO:0019585)3.82676410
97uronic acid metabolic process (GO:0006063)3.82676410
98regulation of protein activation cascade (GO:2000257)3.81970166
99actin filament-based movement (GO:0030048)3.78461898
100glycine metabolic process (GO:0006544)3.76006909
101fatty acid transmembrane transport (GO:1902001)3.73737569
102negative regulation of fibrinolysis (GO:0051918)3.72841333
103regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.72712949
104glycogen catabolic process (GO:0005980)3.71571879
105positive regulation of triglyceride lipase activity (GO:0061365)3.65374019
106positive regulation of lipoprotein lipase activity (GO:0051006)3.65374019
107regulation of complement activation (GO:0030449)3.61130359
108regulation of sequestering of triglyceride (GO:0010889)3.59617009
109gluconeogenesis (GO:0006094)3.58422904
110drug metabolic process (GO:0017144)3.58248041
111tricarboxylic acid cycle (GO:0006099)3.58229696
112cardiac myofibril assembly (GO:0055003)3.57201602
113regulation of fibrinolysis (GO:0051917)3.55641002
114regulation of cholesterol homeostasis (GO:2000188)3.55287920
115indole-containing compound metabolic process (GO:0042430)3.52963983
116high-density lipoprotein particle remodeling (GO:0034375)3.52467138
117flavonoid metabolic process (GO:0009812)3.50393377
118regulation of triglyceride catabolic process (GO:0010896)3.49365921
119response to muscle activity (GO:0014850)3.48313916
120nonribosomal peptide biosynthetic process (GO:0019184)3.47949215
121acylglycerol homeostasis (GO:0055090)3.46534914
122triglyceride homeostasis (GO:0070328)3.46534914
123small molecule catabolic process (GO:0044282)3.44647788
124fructose metabolic process (GO:0006000)3.44476686
125glucan catabolic process (GO:0009251)3.44205029
126fatty acid homeostasis (GO:0055089)3.41766624
127hexose biosynthetic process (GO:0019319)3.38655305
128bile acid and bile salt transport (GO:0015721)3.38482590
129carnitine transport (GO:0015879)3.37402967
130amino-acid betaine transport (GO:0015838)3.37402967
131negative regulation of sterol transport (GO:0032372)3.36263094
132negative regulation of cholesterol transport (GO:0032375)3.36263094
133arginine metabolic process (GO:0006525)3.35960263
134dicarboxylic acid metabolic process (GO:0043648)3.35237420
135blood coagulation, intrinsic pathway (GO:0007597)3.31956980
136regulation of actin filament-based movement (GO:1903115)3.28917067
137cellular polysaccharide catabolic process (GO:0044247)3.24599877
138cardiac muscle hypertrophy (GO:0003300)3.17070442
139regulation of cell communication by electrical coupling (GO:0010649)3.15958768
140monosaccharide biosynthetic process (GO:0046364)3.13434419
141skeletal muscle fiber development (GO:0048741)3.12007478
142fibrinolysis (GO:0042730)3.10812352
143regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.10742887
144muscle contraction (GO:0006936)3.10234253
145striated muscle hypertrophy (GO:0014897)3.07221860
146skeletal muscle adaptation (GO:0043501)3.05552145
147actomyosin structure organization (GO:0031032)3.02973030
148regulation of cholesterol esterification (GO:0010872)3.02249032
149glycogen biosynthetic process (GO:0005978)3.02246838
150glucan biosynthetic process (GO:0009250)3.02246838
151polysaccharide catabolic process (GO:0000272)2.93898957
152regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.93805192
153regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.93033749
154regulation of plasminogen activation (GO:0010755)2.93008582
155regulation of fatty acid biosynthetic process (GO:0042304)2.91356401
156acylglycerol catabolic process (GO:0046464)2.90980444
157neutral lipid catabolic process (GO:0046461)2.90980444
158acute-phase response (GO:0006953)2.90424118
159triglyceride catabolic process (GO:0019433)2.89552003
160carnitine transmembrane transport (GO:1902603)2.89513122
161positive regulation of lipid catabolic process (GO:0050996)2.88220775
162macromolecular complex remodeling (GO:0034367)2.87964613
163plasma lipoprotein particle remodeling (GO:0034369)2.87964613

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.61438689
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.52286664
3LXR_22158963_ChIP-Seq_LIVER_Mouse5.86501777
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.63295628
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.18081632
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.47246167
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.83658171
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.69307455
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.27315717
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.55738878
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.18409683
12TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.07657498
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.4496491
14BP1_19119308_ChIP-ChIP_Hs578T_Human1.73629630
15CLOCK_20551151_ChIP-Seq_293T_Human1.70973046
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.70812329
17* FOXA2_19822575_ChIP-Seq_HepG2_Human1.61881502
18CTCF_27219007_Chip-Seq_Bcells_Human1.59277385
19TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58463449
20CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.55739752
21ESR1_21235772_ChIP-Seq_MCF-7_Human1.53537387
22ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.51503701
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49501950
24* HNF4A_19822575_ChIP-Seq_HepG2_Human1.49109194
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45438819
26DNAJC2_21179169_ChIP-ChIP_NT2_Human1.42838020
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.42650923
28SMC4_20622854_ChIP-Seq_HELA_Human1.40047173
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.39416170
30P68_20966046_ChIP-Seq_HELA_Human1.33714455
31CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.30644029
32ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21525786
33ZFP281_18757296_ChIP-ChIP_E14_Mouse1.21278385
34GATA1_22025678_ChIP-Seq_K562_Human1.21071331
35KDM2B_26808549_Chip-Seq_SUP-B15_Human1.18326340
36DROSHA_22980978_ChIP-Seq_HELA_Human1.16584037
37* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16528185
38STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.16134965
39* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.14560007
40TET1_21451524_ChIP-Seq_MESCs_Mouse1.14372589
41CREB1_26743006_Chip-Seq_LNCaP_Human1.14111703
42SA1_27219007_Chip-Seq_Bcells_Human1.13164492
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.12899957
44EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12395370
45* ESR2_21235772_ChIP-Seq_MCF-7_Human1.10459490
46GATA1_19941827_ChIP-Seq_MEL_Mouse1.10165836
47CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07806269
48TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06383432
49KDM2B_26808549_Chip-Seq_K562_Human1.05958508
50TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05518699
51SA1_27219007_Chip-Seq_ERYTHROID_Human1.05175697
52NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02431082
53SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02129762
54GATA4_25053715_ChIP-Seq_YYC3_Human1.02020047
55TCF7_22412390_ChIP-Seq_EML_Mouse0.99970501
56EP300_21415370_ChIP-Seq_HL-1_Mouse0.99505447
57RXRA_24833708_ChIP-Seq_LIVER_Mouse0.99319830
58HTT_18923047_ChIP-ChIP_STHdh_Human0.96380316
59* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.95729053
60ELK3_25401928_ChIP-Seq_HUVEC_Human0.95031122
61CDX2_20551321_ChIP-Seq_CACO-2_Human0.94778149
62THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94700560
63PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94533652
64* KDM2B_26808549_Chip-Seq_DND41_Human0.93721990
65BCOR_27268052_Chip-Seq_Bcells_Human0.93136354
66NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.91220858
67AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.89781242
68VDR_21846776_ChIP-Seq_THP-1_Human0.89160125
69BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88824467
70* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87685806
71P63_26484246_Chip-Seq_KERATINOCYTES_Human0.86776542
72RARB_27405468_Chip-Seq_BRAIN_Mouse0.86351695
73NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.86318460
74ELF1_20517297_ChIP-Seq_JURKAT_Human0.85714310
75E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.85495404
76ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.85319305
77CTCF_21964334_ChIP-Seq_BJAB-B_Human0.84689110
78MYC_27129775_Chip-Seq_CORNEA_Mouse0.84000096
79UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.83932363
80* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.83732965
81TP63_22573176_ChIP-Seq_HFKS_Human0.82694838
82CTCF_21964334_Chip-Seq_Bcells_Human0.82685437
83BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81912532
84JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.81898754
85MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.81881617
86KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.81820638
87BCL6_27268052_Chip-Seq_Bcells_Human0.81586025
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81561097
89Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.80960144
90* RUNX1_27514584_Chip-Seq_MCF-7_Human0.80905309
91E2F1_20622854_ChIP-Seq_HELA_Human0.79861674
92RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.79632873
93NRF2_20460467_ChIP-Seq_MEFs_Mouse0.79601507
94NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.79601507
95SPI1_20517297_ChIP-Seq_HL60_Human0.79552911
96NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.78826017
97AUTS2_25519132_ChIP-Seq_293T-REX_Human0.77992207
98EGR1_19032775_ChIP-ChIP_M12_Human0.76582929
99IRF8_22096565_ChIP-ChIP_GC-B_Human0.76253918
100BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.75684340
101LXR_22292898_ChIP-Seq_THP-1_Human0.74810758
102ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.73700581
103* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.73641114
104KAP1_22055183_ChIP-Seq_ESCs_Mouse0.72729005
105FOXO3_23340844_ChIP-Seq_DLD1_Human0.71240028
106EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.69448249
107CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69272947
108STAT3_1855785_ChIP-Seq_MESCs_Mouse0.68981229
109SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.68475751
110GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.68169148
111CEBPB_22108803_ChIP-Seq_LS180_Human0.67346624
112FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.67021525
113ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.66633245
114* MYC_19915707_ChIP-ChIP_AK7_Human0.65315577
115SALL4_18804426_ChIP-ChIP_XEN_Mouse0.65110740
116SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.63743724
117CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.63703268
118NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.63124779
119PPAR_26484153_Chip-Seq_NCI-H1993_Human0.63110497
120TBX20_22080862_ChIP-Seq_HEART_Mouse0.62466746
121TBX20_22328084_ChIP-Seq_HEART_Mouse0.62466746
122AR_20517297_ChIP-Seq_VCAP_Human0.62237603
123ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.61940450
124PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.61332139
125ESR1_20079471_ChIP-ChIP_T-47D_Human0.60449771
126CBP_21632823_ChIP-Seq_H3396_Human0.60074613
127ESET_19884257_ChIP-Seq_ESCs_Mouse0.59965002
128STAT1_17558387_ChIP-Seq_HELA_Human0.58937477
129TAF2_19829295_ChIP-Seq_ESCs_Human0.58394638
130GATA6_25053715_ChIP-Seq_YYC3_Human0.57678995
131PIAS1_25552417_ChIP-Seq_VCAP_Human0.57189520
132CDX2_22108803_ChIP-Seq_LS180_Human0.56682763
133ERG_21242973_ChIP-ChIP_JURKAT_Human0.55914591
134SOX2_20726797_ChIP-Seq_SW620_Human0.55310240
135FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.55305384
136RACK7_27058665_Chip-Seq_MCF-7_Human0.54475113
137RARA_24833708_ChIP-Seq_LIVER_Mouse0.54383127
138PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.53663095
139FOXA1_25552417_ChIP-Seq_VCAP_Human0.53613665
140SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.52992216
141GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.52757440
142GATA2_19941826_ChIP-Seq_K562_Human0.51822158
143CDX2_19796622_ChIP-Seq_MESCs_Mouse0.51753308
144SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.50919350
145BCAT_22108803_ChIP-Seq_LS180_Human0.50793014
146P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.49944301
147SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.49519886
148ZNF263_19887448_ChIP-Seq_K562_Human0.49490525
149PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.48401426
150SMAD4_21741376_ChIP-Seq_HESCs_Human0.48182415
151FOXH1_21741376_ChIP-Seq_EPCs_Human0.47747656
152OCT4_20526341_ChIP-Seq_ESCs_Human0.47741312
153TAF15_26573619_Chip-Seq_HEK293_Human0.46839639
154CSB_26484114_Chip-Seq_FIBROBLAST_Human0.46703933
155CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.46569893
156GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.45303285

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.08662035
2MP0002139_abnormal_hepatobiliary_system7.67880727
3MP0005085_abnormal_gallbladder_physiolo5.35218131
4MP0005365_abnormal_bile_salt5.23798141
5MP0000751_myopathy4.84360240
6MP0008875_abnormal_xenobiotic_pharmacok4.73883682
7MP0005332_abnormal_amino_acid3.90773367
8MP0004145_abnormal_muscle_electrophysio3.70817272
9MP0003252_abnormal_bile_duct3.64634157
10MP0000749_muscle_degeneration3.57719409
11MP0003806_abnormal_nucleotide_metabolis3.52341946
12MP0003195_calcinosis3.47624939
13MP0004019_abnormal_vitamin_homeostasis3.39308077
14MP0004036_abnormal_muscle_relaxation3.21348029
15MP0002138_abnormal_hepatobiliary_system2.97453989
16MP0010329_abnormal_lipoprotein_level2.74310459
17MP0004043_abnormal_pH_regulation2.64904312
18MP0004087_abnormal_muscle_fiber2.63847512
19MP0004084_abnormal_cardiac_muscle2.61642518
20MP0009643_abnormal_urine_homeostasis2.43392569
21MP0002106_abnormal_muscle_physiology2.36331180
22MP0001666_abnormal_nutrient_absorption2.27239519
23MP0000759_abnormal_skeletal_muscle2.22304190
24MP0005083_abnormal_biliary_tract2.20365383
25MP0002269_muscular_atrophy2.18783502
26MP0002332_abnormal_exercise_endurance2.12965318
27MP0009840_abnormal_foam_cell2.02616646
28MP0003191_abnormal_cellular_cholesterol2.01875606
29MP0004233_abnormal_muscle_weight2.00362657
30MP0005369_muscle_phenotype1.96601899
31MP0005620_abnormal_muscle_contractility1.92215226
32MP0002972_abnormal_cardiac_muscle1.89781757
33MP0002118_abnormal_lipid_homeostasis1.89435509
34MP0005636_abnormal_mineral_homeostasis1.88063504
35MP0005319_abnormal_enzyme/_coenzyme1.84297791
36MP0005584_abnormal_enzyme/coenzyme_acti1.81008606
37MP0004215_abnormal_myocardial_fiber1.79615551
38MP0000609_abnormal_liver_physiology1.75376913
39MP0000750_abnormal_muscle_regeneration1.69470989
40MP0006138_congestive_heart_failure1.68012436
41MP0001765_abnormal_ion_homeostasis1.63403797
42MP0004510_myositis1.62881545
43MP0001756_abnormal_urination1.62013112
44MP0003186_abnormal_redox_activity1.59218760
45MP0010630_abnormal_cardiac_muscle1.54538813
46MP0001764_abnormal_homeostasis1.53851225
47MP0004185_abnormal_adipocyte_glucose1.47948686
48MP0005385_cardiovascular_system_phenoty1.47755862
49MP0001544_abnormal_cardiovascular_syste1.47755862
50MP0003879_abnormal_hair_cell1.43490281
51MP0005451_abnormal_body_composition1.43016985
52MP0002136_abnormal_kidney_physiology1.42954382
53MP0004484_altered_response_of1.40392243
54MP0003868_abnormal_feces_composition1.33406039
55MP0005670_abnormal_white_adipose1.29164977
56MP0002876_abnormal_thyroid_physiology1.26482939
57MP0006036_abnormal_mitochondrial_physio1.24789694
58MP0005084_abnormal_gallbladder_morpholo1.19855189
59MP0009780_abnormal_chondrocyte_physiolo1.19150714
60MP0005058_abnormal_lysosome_morphology1.14885274
61MP0005535_abnormal_body_temperature1.05070706
62MP0002108_abnormal_muscle_morphology1.04549770
63MP0000003_abnormal_adipose_tissue1.04371822
64MP0003137_abnormal_impulse_conducting1.04016225
65MP0009764_decreased_sensitivity_to1.00544539
66MP0000598_abnormal_liver_morphology0.98631209
67MP0000733_abnormal_muscle_development0.95772514
68MP0002127_abnormal_cardiovascular_syste0.93989713
69MP0008775_abnormal_heart_ventricle0.93165710
70MP0004270_analgesia0.93088256
71MP0009642_abnormal_blood_homeostasis0.91061187
72MP0000013_abnormal_adipose_tissue0.88997377
73MP0005666_abnormal_adipose_tissue0.86744623
74MP0001661_extended_life_span0.85208696
75MP0002928_abnormal_bile_duct0.84839493
76MP0008469_abnormal_protein_level0.82701186
77MP0005647_abnormal_sex_gland0.81872436
78MP0002078_abnormal_glucose_homeostasis0.81708711
79MP0004130_abnormal_muscle_cell0.79539882
80MP0000538_abnormal_urinary_bladder0.79511457
81MP0005220_abnormal_exocrine_pancreas0.79504316
82MP0002837_dystrophic_cardiac_calcinosis0.79124247
83MP0000604_amyloidosis0.78284039
84MP0002971_abnormal_brown_adipose0.75641892
85MP0003221_abnormal_cardiomyocyte_apopto0.75283843
86MP0003011_delayed_dark_adaptation0.75266084
87MP0000230_abnormal_systemic_arterial0.74705776
88MP0003656_abnormal_erythrocyte_physiolo0.72444689
89MP0009763_increased_sensitivity_to0.71258615
90MP0003705_abnormal_hypodermis_morpholog0.69601482
91MP0003878_abnormal_ear_physiology0.69448340
92MP0005377_hearing/vestibular/ear_phenot0.69448340
93MP0005408_hypopigmentation0.69128628
94MP0002168_other_aberrant_phenotype0.68632370
95MP0006035_abnormal_mitochondrial_morpho0.67027256
96MP0003329_amyloid_beta_deposits0.66343870
97MP0003828_pulmonary_edema0.65799959
98MP0008961_abnormal_basal_metabolism0.65061947
99MP0005376_homeostasis/metabolism_phenot0.64998588
100MP0004858_abnormal_nervous_system0.64377728
101MP0005167_abnormal_blood-brain_barrier0.63859335
102MP0003638_abnormal_response/metabolism_0.63683364
103MP0009697_abnormal_copulation0.63432913
104MP0004085_abnormal_heartbeat0.63342271
105MP0001958_emphysema0.62877376
106MP0004147_increased_porphyrin_level0.62671811
107MP0003690_abnormal_glial_cell0.60745819
108MP0005334_abnormal_fat_pad0.60680778
109MP0009765_abnormal_xenobiotic_induced0.60299066
110MP0003646_muscle_fatigue0.56437367
111MP0005395_other_phenotype0.54915708
112MP0005266_abnormal_metabolism0.54513158
113MP0002135_abnormal_kidney_morphology0.53629945
114MP0002254_reproductive_system_inflammat0.53253493
115MP0000343_altered_response_to0.51958525
116MP0003953_abnormal_hormone_level0.51565897
117MP0002822_catalepsy0.50823117
118MP0004885_abnormal_endolymph0.50468267
119MP0003300_gastrointestinal_ulcer0.50220947
120MP0003724_increased_susceptibility_to0.49221758
121MP0005409_darkened_coat_color0.48445288
122MP0002796_impaired_skin_barrier0.46155877
123MP0003959_abnormal_lean_body0.43639825
124MP0004264_abnormal_extraembryonic_tissu0.42854099
125MP0008874_decreased_physiological_sensi0.42234936
126MP0003075_altered_response_to0.37270962
127MP0005166_decreased_susceptibility_to0.36038641
128MP0010368_abnormal_lymphatic_system0.35918609
129MP0005448_abnormal_energy_balance0.35820578
130MP0005375_adipose_tissue_phenotype0.35574507
131MP0008872_abnormal_physiological_respon0.35127313
132MP0000747_muscle_weakness0.33641222
133MP0010234_abnormal_vibrissa_follicle0.32954960
134MP0002896_abnormal_bone_mineralization0.31988860
135MP0009115_abnormal_fat_cell0.31112696
136MP0009672_abnormal_birth_weight0.29992096
137MP0005330_cardiomyopathy0.28454964
138MP0005165_increased_susceptibility_to0.28087404
139MP0002069_abnormal_eating/drinking_beha0.27760911
140MP0008873_increased_physiological_sensi0.26995309
141MP0004782_abnormal_surfactant_physiolog0.26513745

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)7.36222122
2Nemaline bodies (HP:0003798)7.28095933
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.11516307
4Exercise-induced myalgia (HP:0003738)6.41905165
5Type 1 muscle fiber predominance (HP:0003803)5.88948999
6Abnormality of aromatic amino acid family metabolism (HP:0004338)5.77589587
7Gout (HP:0001997)5.34616510
8Intrahepatic cholestasis (HP:0001406)5.28735557
9Hyperglycinuria (HP:0003108)5.20270912
10Exercise-induced muscle cramps (HP:0003710)5.13419773
11Abnormality of glutamine family amino acid metabolism (HP:0010902)5.00941624
12Abnormality of glycine metabolism (HP:0010895)4.74113407
13Abnormality of serine family amino acid metabolism (HP:0010894)4.74113407
14Ketosis (HP:0001946)4.67829324
15Muscle hypertrophy of the lower extremities (HP:0008968)4.61845075
16Xanthomatosis (HP:0000991)4.58389800
17Abnormality of monocarboxylic acid metabolism (HP:0010996)4.55557730
18Deep venous thrombosis (HP:0002625)4.51004664
19Hyporeflexia of lower limbs (HP:0002600)4.44052878
20Hyperglycinemia (HP:0002154)4.42807158
21Rhabdomyolysis (HP:0003201)4.41515879
22EMG: myopathic abnormalities (HP:0003458)4.37787176
23Muscle fiber splitting (HP:0003555)4.31803931
24Hyperammonemia (HP:0001987)4.31549371
25Myopathic facies (HP:0002058)4.29230877
26Calf muscle hypertrophy (HP:0008981)4.23909266
27Abnormality of purine metabolism (HP:0004352)4.23319336
28Ketoacidosis (HP:0001993)4.22429982
29Myoglobinuria (HP:0002913)4.20041752
30Proximal tubulopathy (HP:0000114)4.18244004
31Centrally nucleated skeletal muscle fibers (HP:0003687)4.06906070
32Abnormality of aspartate family amino acid metabolism (HP:0010899)4.06115506
33Asymmetric septal hypertrophy (HP:0001670)4.01010759
34Sudden death (HP:0001699)3.99244340
35Distal lower limb muscle weakness (HP:0009053)3.95300988
36Abnormality of fatty-acid metabolism (HP:0004359)3.88650847
37Hyperuricemia (HP:0002149)3.86389422
38Increased purine levels (HP:0004368)3.86389422
39Bundle branch block (HP:0011710)3.80015577
40Abnormality of the calf musculature (HP:0001430)3.79567898
41Hypokalemic alkalosis (HP:0001949)3.78883709
42Increased circulating renin level (HP:0000848)3.75726355
43Abnormality of sulfur amino acid metabolism (HP:0004339)3.75535451
44Generalized aminoaciduria (HP:0002909)3.74015955
45Abnormality of nucleobase metabolism (HP:0010932)3.72923696
46Prolonged partial thromboplastin time (HP:0003645)3.72241181
47Metabolic alkalosis (HP:0200114)3.59870339
48Complement deficiency (HP:0004431)3.59238474
49Alkalosis (HP:0001948)3.56496247
50Hypobetalipoproteinemia (HP:0003563)3.55488225
51Neck muscle weakness (HP:0000467)3.51195660
52Hyperactive renin-angiotensin system (HP:0000841)3.50547764
53Delayed CNS myelination (HP:0002188)3.48794070
54Abnormality of skeletal muscle fiber size (HP:0012084)3.48606273
55Hyperlipoproteinemia (HP:0010980)3.46238031
56Hypoglycemic coma (HP:0001325)3.40467698
57Distal arthrogryposis (HP:0005684)3.40428900
58Increased connective tissue (HP:0009025)3.32946795
59Hypomagnesemia (HP:0002917)3.29958874
60Round ear (HP:0100830)3.29389278
61Abnormal urine output (HP:0012590)3.29307637
62Abnormality of the left ventricular outflow tract (HP:0011103)3.29077824
63Subaortic stenosis (HP:0001682)3.29077824
64Polyuria (HP:0000103)3.28565396
65Difficulty running (HP:0009046)3.25659657
66Dicarboxylic aciduria (HP:0003215)3.18450874
67Abnormality of dicarboxylic acid metabolism (HP:0010995)3.18450874
68Abnormality of chloride homeostasis (HP:0011422)3.16578795
69Rimmed vacuoles (HP:0003805)3.16134421
70Joint hemorrhage (HP:0005261)3.14550867
71Metabolic acidosis (HP:0001942)3.14124430
72Vascular calcification (HP:0004934)3.13838943
73Abnormality of renal excretion (HP:0011036)3.12763635
74Abnormality of urine glucose concentration (HP:0011016)3.11269684
75Glycosuria (HP:0003076)3.11269684
76Increased variability in muscle fiber diameter (HP:0003557)3.10516674
77Fat malabsorption (HP:0002630)3.07320765
78Heart block (HP:0012722)3.06203622
79Ventricular tachycardia (HP:0004756)2.99830428
80Abnormality of serum amino acid levels (HP:0003112)2.95980727
81Abnormal atrioventricular conduction (HP:0005150)2.94846528
82Muscle stiffness (HP:0003552)2.90140954
83Lethargy (HP:0001254)2.90115219
84Epidermoid cyst (HP:0200040)2.88940176
85Abnormality of methionine metabolism (HP:0010901)2.85152585
86Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.84429449
87Ulnar deviation of the wrist (HP:0003049)2.83762244
88Hydroxyprolinuria (HP:0003080)2.77982809
89Abnormality of proline metabolism (HP:0010907)2.77982809
90Cardiovascular calcification (HP:0011915)2.77798300
91EMG: neuropathic changes (HP:0003445)2.75810638
92Hypolipoproteinemia (HP:0010981)2.75064564
93Atrioventricular block (HP:0001678)2.73356757
94Abnormality of pyrimidine metabolism (HP:0004353)2.72132417
95Abnormality of magnesium homeostasis (HP:0004921)2.71434934
96Abnormality of the common coagulation pathway (HP:0010990)2.71259401
97Dilated cardiomyopathy (HP:0001644)2.67038022
98Vomiting (HP:0002013)2.66500553
99Conjugated hyperbilirubinemia (HP:0002908)2.60999004
100Malnutrition (HP:0004395)2.60949229
101Rickets (HP:0002748)2.58278897
102Enlarged kidneys (HP:0000105)2.56660802
103Abnormal drinking behavior (HP:0030082)2.55447458
104Polydipsia (HP:0001959)2.55447458
105Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.53998802
106Hyperbilirubinemia (HP:0002904)2.52628279
107Hypoalphalipoproteinemia (HP:0003233)2.52188369
108Bulbar palsy (HP:0001283)2.51845563
109Ragged-red muscle fibers (HP:0003200)2.50676779
110Frequent falls (HP:0002359)2.50591721
111Areflexia of lower limbs (HP:0002522)2.49989412
112Distal lower limb amyotrophy (HP:0008944)2.49502241
113Mildly elevated creatine phosphokinase (HP:0008180)2.48872776
114Hyperphosphaturia (HP:0003109)2.45596089
115Abnormality of complement system (HP:0005339)2.45292236
116Sensorimotor neuropathy (HP:0007141)2.45206459
117Glomerulonephritis (HP:0000099)2.45084208
118Hepatocellular carcinoma (HP:0001402)2.44138702
119Lipoatrophy (HP:0100578)2.43617084
120Irritability (HP:0000737)2.43301294
121Neonatal onset (HP:0003623)2.43283536
122Nephrolithiasis (HP:0000787)2.41589102
123Renal tubular acidosis (HP:0001947)2.40126036
124Cerebral edema (HP:0002181)2.38216653
125Abnormality of the intrinsic pathway (HP:0010989)2.34826607
126Abnormal enzyme/coenzyme activity (HP:0012379)2.34539740
127Abnormality of renin-angiotensin system (HP:0000847)2.34483546
128Late onset (HP:0003584)2.33876117
129Renal salt wasting (HP:0000127)2.32709860
130Steatorrhea (HP:0002570)2.31359950
131Hyperaldosteronism (HP:0000859)2.31049343
132Generalized muscle weakness (HP:0003324)2.27335842
133Tetany (HP:0001281)2.26331446
134Myotonia (HP:0002486)2.24977126
135Abnormality of the foot musculature (HP:0001436)2.23212048
136Spastic diplegia (HP:0001264)2.21076447
137Ventricular arrhythmia (HP:0004308)2.19946215
138Abnormal urine phosphate concentration (HP:0012599)2.19694513
139Hypophosphatemia (HP:0002148)2.17469159
140Confusion (HP:0001289)2.15334376
141Abnormality of alkaline phosphatase activity (HP:0004379)2.14964535
142Foot dorsiflexor weakness (HP:0009027)2.12772922
143Systemic lupus erythematosus (HP:0002725)2.10408966
144Hypercholesterolemia (HP:0003124)2.09527714
145Pancreatitis (HP:0001733)2.08005560
146Methylmalonic aciduria (HP:0012120)2.07154157
147Gowers sign (HP:0003391)2.05946755
148Right ventricular cardiomyopathy (HP:0011663)2.05082663
149Cholelithiasis (HP:0001081)2.04387250
150Calcaneovalgus deformity (HP:0001848)2.01284287
151Nausea (HP:0002018)2.00338844
152Hypophosphatemic rickets (HP:0004912)1.99869213
153Increased serum pyruvate (HP:0003542)1.98104394
154Syncope (HP:0001279)1.97961370
155Malignant hyperthermia (HP:0002047)1.97421127
156Hemorrhage of the eye (HP:0011885)1.96535478
157Elevated alkaline phosphatase (HP:0003155)1.95692274
158Absent phalangeal crease (HP:0006109)1.93299989
159Ventricular fibrillation (HP:0001663)1.92951929
160Progressive muscle weakness (HP:0003323)1.92204995
161Scapular winging (HP:0003691)1.92091876
162Oligomenorrhea (HP:0000876)1.91702136
163Hypoglycemic seizures (HP:0002173)1.91252684
164Abnormality of glycolysis (HP:0004366)1.90071621
165Hyperkalemia (HP:0002153)1.88343275
166Myocardial infarction (HP:0001658)1.87835422
167Difficulty climbing stairs (HP:0003551)1.85997231
168Abnormality of the Achilles tendon (HP:0005109)1.84111306
169Abnormal gallbladder morphology (HP:0012437)1.81127388
170Increased muscle lipid content (HP:0009058)1.80846341
171Lower limb amyotrophy (HP:0007210)1.79856714
172Limb-girdle muscle atrophy (HP:0003797)1.74796054
173Recurrent gram-negative bacterial infections (HP:0005420)1.72757642
174Deformed tarsal bones (HP:0008119)1.72415188
175Atrial fibrillation (HP:0005110)1.67847704
176Nephritis (HP:0000123)1.65434684

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.34714307
2WNK45.91922676
3TTN5.57355304
4WNK35.15651408
5OXSR14.69298497
6PHKG14.52847133
7FGFR43.06213730
8ERN12.76052255
9STK392.60652306
10SIK12.39054559
11STK38L2.37466730
12INSRR2.24280735
13MUSK1.92134666
14PDK41.88600314
15PDK31.88600314
16MST1R1.87096187
17ERBB41.84627160
18EEF2K1.81287649
19MAPKAPK31.71899151
20PINK11.68993607
21DMPK1.55772329
22ICK1.54601610
23PRPF4B1.54178876
24SGK4941.50678875
25SGK2231.50678875
26TAOK31.47025352
27MAP2K41.42771358
28MAPK111.29517959
29PDK21.29151892
30TRIB31.26181583
31MAP3K71.23904553
32PIK3CA1.21998619
33LATS11.20407376
34EPHB11.17462610
35NEK11.14524445
36FRK1.12149984
37SGK31.09629729
38ABL21.07279652
39PIK3CG1.05314406
40TIE11.04060636
41PRKAA21.02167535
42WNK11.02138357
43SGK21.01393235
44STK380.98692642
45PTK60.96374245
46NEK90.93447690
47GRK60.92817686
48LMTK20.91937402
49PRKD30.91782573
50ARAF0.87982530
51MAP3K30.87633446
52LATS20.86135815
53LIMK10.84859194
54TRPM70.84366142
55GSK3A0.83933386
56TAOK20.83471737
57IRAK30.83046126
58KSR20.81670439
59MAPK150.79644720
60PRKAA10.77347331
61TGFBR20.76825993
62MAP2K30.76233866
63TYK20.75009410
64TESK10.74266237
65MAP3K140.73369497
66CAMK2D0.72861810
67JAK20.71560722
68MAP3K10.71184220
69MYLK0.70752551
70FGFR20.69967910
71PKN20.69485931
72PDPK10.69476403
73PRKCZ0.68960283
74EPHA20.67913379
75MET0.65632448
76AKT20.65108707
77DYRK1B0.64510422
78DAPK20.62543451
79PRKD10.61733241
80CAMK10.61710730
81PTK20.60584399
82SMG10.60418200
83MARK10.59678319
84MAPK120.59030671
85FLT30.57445049
86MOS0.56155090
87PRKACG0.55147198
88CAMK2B0.52787282
89CDC42BPA0.52448224
90ZAP700.51133708
91MAPK40.49350480
92RPS6KL10.48687046
93RPS6KC10.48687046
94CAMK2G0.48684715
95TAOK10.48191050
96PAK30.48125712
97JAK10.48020664
98MARK20.47090367
99IRAK20.46474660
100PRKG10.45342129
101MTOR0.43242710
102ERBB20.43146439
103PDK10.43009920
104ROCK10.42724106
105NME10.41942139
106TNK20.40399832
107IRAK10.39857708
108TBK10.39852269
109KDR0.39806314
110RPS6KA20.39657860
111LRRK20.39499798
112MAP2K60.38724043
113SGK10.38654895
114RET0.36610438
115OBSCN0.36517731
116MAP3K90.35333240
117RIPK10.35269806
118CAMK1D0.34060910
119RPS6KA60.33832632
120PRKCQ0.31995327
121RPS6KA30.31907309
122MAP3K110.31510485
123CAMK2A0.31360991
124CAMK1G0.31004825
125FER0.29961052
126MAP3K50.29361999
127CSK0.28902652
128CCNB10.28854386
129PRKG20.28317719
130PRKCH0.27984510
131MAP2K10.25860879
132CSNK1G10.25075616
133MAP3K60.24643357
134PRKCA0.24081682
135IGF1R0.23585957
136PKN10.23567083
137EPHA30.22984153
138PRKACA0.22584203
139MAPK70.20361468
140PRKCG0.19940249
141EPHA40.19629299
142MAP3K130.19306471
143FGFR30.17716933
144PRKCD0.17015951
145CAMK40.16855055
146MAP3K20.15484189
147STK110.13959703
148PHKG20.13557726

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.55604976
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.38165137
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.99335344
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.99285725
5Butanoate metabolism_Homo sapiens_hsa006502.96724388
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.94209840
7Tryptophan metabolism_Homo sapiens_hsa003802.73229378
8Fatty acid degradation_Homo sapiens_hsa000712.70149871
9Nitrogen metabolism_Homo sapiens_hsa009102.65595478
10Propanoate metabolism_Homo sapiens_hsa006402.65210994
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.56093173
12Arginine biosynthesis_Homo sapiens_hsa002202.49055740
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.44484357
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.43289459
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.43146617
16Peroxisome_Homo sapiens_hsa041462.41108496
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.15793705
18Cyanoamino acid metabolism_Homo sapiens_hsa004602.05294454
19Fatty acid metabolism_Homo sapiens_hsa012122.01291589
20beta-Alanine metabolism_Homo sapiens_hsa004101.94461688
21Complement and coagulation cascades_Homo sapiens_hsa046101.80175219
22PPAR signaling pathway_Homo sapiens_hsa033201.79744155
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.78219806
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.75415036
25Histidine metabolism_Homo sapiens_hsa003401.70401028
26* Pyruvate metabolism_Homo sapiens_hsa006201.69782276
27Sulfur metabolism_Homo sapiens_hsa009201.62897234
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.62587149
29Bile secretion_Homo sapiens_hsa049761.58286813
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.55595669
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.52860538
32Chemical carcinogenesis_Homo sapiens_hsa052041.50980933
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.50539151
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.48014103
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.47956615
36Carbon metabolism_Homo sapiens_hsa012001.43456687
37Selenocompound metabolism_Homo sapiens_hsa004501.41491957
38Phenylalanine metabolism_Homo sapiens_hsa003601.40396487
39Dilated cardiomyopathy_Homo sapiens_hsa054141.38021024
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.34842915
41Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.34549159
42Starch and sucrose metabolism_Homo sapiens_hsa005001.34216095
43Retinol metabolism_Homo sapiens_hsa008301.31543898
44Vitamin digestion and absorption_Homo sapiens_hsa049771.29658644
45Cardiac muscle contraction_Homo sapiens_hsa042601.26037480
46Fatty acid elongation_Homo sapiens_hsa000621.25929345
47Arginine and proline metabolism_Homo sapiens_hsa003301.20702014
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.15056830
49Biosynthesis of amino acids_Homo sapiens_hsa012301.14895324
50Tyrosine metabolism_Homo sapiens_hsa003501.14001885
51Caffeine metabolism_Homo sapiens_hsa002321.12547238
52Folate biosynthesis_Homo sapiens_hsa007901.11669198
53Glutathione metabolism_Homo sapiens_hsa004801.07181766
54Lysine degradation_Homo sapiens_hsa003101.01879449
55Staphylococcus aureus infection_Homo sapiens_hsa051501.00416054
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00088894
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.93622386
58ABC transporters_Homo sapiens_hsa020100.93172924
59Steroid biosynthesis_Homo sapiens_hsa001000.89701832
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87995867
61Glycerolipid metabolism_Homo sapiens_hsa005610.87865003
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79101242
63Sulfur relay system_Homo sapiens_hsa041220.75008091
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74881870
65Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.73842830
66Fat digestion and absorption_Homo sapiens_hsa049750.73038049
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69624307
68Circadian rhythm_Homo sapiens_hsa047100.66933823
69Vitamin B6 metabolism_Homo sapiens_hsa007500.64002687
70Pentose phosphate pathway_Homo sapiens_hsa000300.56536988
71Metabolic pathways_Homo sapiens_hsa011000.54082770
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48699103
73Fructose and mannose metabolism_Homo sapiens_hsa000510.47269175
74Collecting duct acid secretion_Homo sapiens_hsa049660.35487742
75One carbon pool by folate_Homo sapiens_hsa006700.35228996
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33422839
77Fatty acid biosynthesis_Homo sapiens_hsa000610.28709097
78Other glycan degradation_Homo sapiens_hsa005110.27597860
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.27501844
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.26960991
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26351798
82Oxytocin signaling pathway_Homo sapiens_hsa049210.25884818
83Renin secretion_Homo sapiens_hsa049240.24442754
84Calcium signaling pathway_Homo sapiens_hsa040200.23713478
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23650818
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.23455133
87Protein digestion and absorption_Homo sapiens_hsa049740.23108549
88Insulin resistance_Homo sapiens_hsa049310.21812859
89Galactose metabolism_Homo sapiens_hsa000520.20285368
90Mineral absorption_Homo sapiens_hsa049780.19042614
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.14554015
92Pertussis_Homo sapiens_hsa051330.14173777
93Amoebiasis_Homo sapiens_hsa051460.13809048
94Tight junction_Homo sapiens_hsa045300.13637080
95Gastric acid secretion_Homo sapiens_hsa049710.13246477
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.12527470
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.12241179
98Arachidonic acid metabolism_Homo sapiens_hsa005900.12044725
99GnRH signaling pathway_Homo sapiens_hsa049120.11700771
100Oxidative phosphorylation_Homo sapiens_hsa001900.11060007
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.10346725
102Prion diseases_Homo sapiens_hsa050200.09627820
103Glucagon signaling pathway_Homo sapiens_hsa049220.08829460
104Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.08722165
105Thyroid hormone synthesis_Homo sapiens_hsa049180.08388711
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.07683513
107Lysosome_Homo sapiens_hsa041420.07028691
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.05985927
109Renin-angiotensin system_Homo sapiens_hsa046140.05192619
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.04971882
111AMPK signaling pathway_Homo sapiens_hsa041520.04723012
112Linoleic acid metabolism_Homo sapiens_hsa005910.02316715
113Hepatitis C_Homo sapiens_hsa05160-0.1665335
114Alzheimers disease_Homo sapiens_hsa05010-0.1439558
115Insulin signaling pathway_Homo sapiens_hsa04910-0.1306810
116Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1130003
117Regulation of autophagy_Homo sapiens_hsa04140-0.0623080
118Parkinsons disease_Homo sapiens_hsa05012-0.0431914
119Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524-0.0184929
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.0090002

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