LDLR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)7.52017965
2L-phenylalanine catabolic process (GO:0006559)5.91668769
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.91668769
4cellular response to follicle-stimulating hormone stimulus (GO:0071372)5.69821988
5L-phenylalanine metabolic process (GO:0006558)5.63575487
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.63575487
7desmosome organization (GO:0002934)5.16467938
8alpha-linolenic acid metabolic process (GO:0036109)5.00349828
9aromatic amino acid family catabolic process (GO:0009074)4.89268340
10response to follicle-stimulating hormone (GO:0032354)4.87891887
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.85092974
12peptidyl-glutamic acid carboxylation (GO:0017187)4.84254265
13protein carboxylation (GO:0018214)4.84254265
14negative regulation of fibrinolysis (GO:0051918)4.80636724
15cell adhesion mediated by integrin (GO:0033627)4.47175942
16glucocorticoid biosynthetic process (GO:0006704)4.39135401
17urea cycle (GO:0000050)4.37965638
18urea metabolic process (GO:0019627)4.37965638
19high-density lipoprotein particle remodeling (GO:0034375)4.37231277
20regulation of fibrinolysis (GO:0051917)4.33207405
21skin morphogenesis (GO:0043589)4.28704672
22bile acid biosynthetic process (GO:0006699)4.27352679
23cell-substrate junction assembly (GO:0007044)4.25656002
24complement activation, alternative pathway (GO:0006957)4.22047759
25kynurenine metabolic process (GO:0070189)4.16266523
26sulfur amino acid catabolic process (GO:0000098)4.16216945
27glyoxylate metabolic process (GO:0046487)4.10263211
28regulation of protein activation cascade (GO:2000257)4.09602252
29androgen biosynthetic process (GO:0006702)4.09396465
30tyrosine metabolic process (GO:0006570)4.06708325
31indole-containing compound catabolic process (GO:0042436)3.97249123
32indolalkylamine catabolic process (GO:0046218)3.97249123
33tryptophan catabolic process (GO:0006569)3.97249123
34nitrogen cycle metabolic process (GO:0071941)3.97026024
35negative regulation of cholesterol transport (GO:0032375)3.92836854
36negative regulation of sterol transport (GO:0032372)3.92836854
37reverse cholesterol transport (GO:0043691)3.88767216
38cysteine metabolic process (GO:0006534)3.86468830
39regulation of complement activation (GO:0030449)3.86096437
40tryptophan metabolic process (GO:0006568)3.86080847
41* plasma lipoprotein particle clearance (GO:0034381)3.83729311
42* regulation of cholesterol homeostasis (GO:2000188)3.81389591
43bile acid metabolic process (GO:0008206)3.81196311
44phospholipid efflux (GO:0033700)3.76644774
45C21-steroid hormone biosynthetic process (GO:0006700)3.71962557
46homocysteine metabolic process (GO:0050667)3.71663744
47atrioventricular valve morphogenesis (GO:0003181)3.69297261
48protein-lipid complex remodeling (GO:0034368)3.65336062
49macromolecular complex remodeling (GO:0034367)3.65336062
50plasma lipoprotein particle remodeling (GO:0034369)3.65336062
51cholesterol efflux (GO:0033344)3.64448635
52regulation of hippo signaling (GO:0035330)3.64426607
53estrogen biosynthetic process (GO:0006703)3.64239740
54endothelial cell chemotaxis (GO:0035767)3.63170196
55aromatic amino acid family metabolic process (GO:0009072)3.60686781
56cellular response to gonadotropin stimulus (GO:0071371)3.59005077
57regulation of cholesterol esterification (GO:0010872)3.58991766
58regulation of triglyceride catabolic process (GO:0010896)3.58903189
59fibrinolysis (GO:0042730)3.58708650
60cholesterol biosynthetic process (GO:0006695)3.55273478
61regulation of cholesterol biosynthetic process (GO:0045540)3.53976271
62dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.53042297
63mesodermal cell differentiation (GO:0048333)3.52624020
64surfactant homeostasis (GO:0043129)3.51774052
65response to gonadotropin (GO:0034698)3.51286146
66triglyceride homeostasis (GO:0070328)3.51212643
67acylglycerol homeostasis (GO:0055090)3.51212643
68cell migration involved in sprouting angiogenesis (GO:0002042)3.49829514
69plasma lipoprotein particle assembly (GO:0034377)3.43863227
70bundle of His cell to Purkinje myocyte communication (GO:0086069)3.42502286
71cellular glucuronidation (GO:0052695)3.40015298
72bile acid and bile salt transport (GO:0015721)3.38929817
73negative regulation of keratinocyte proliferation (GO:0010839)3.36928365
74fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.36842564
754-hydroxyproline metabolic process (GO:0019471)3.35892024
76glucocorticoid metabolic process (GO:0008211)3.35806491
77protein-lipid complex assembly (GO:0065005)3.35674772
78coenzyme catabolic process (GO:0009109)3.34822584
79regulation of transforming growth factor beta2 production (GO:0032909)3.33443279
80positive regulation of hormone biosynthetic process (GO:0046886)3.31701976
81negative regulation of chondrocyte differentiation (GO:0032331)3.29208727
82fatty-acyl-CoA biosynthetic process (GO:0046949)3.28474085
83phospholipid homeostasis (GO:0055091)3.28056889
84epithelial cell-cell adhesion (GO:0090136)3.27284035
85long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.25440814
86cellular response to antibiotic (GO:0071236)3.23559240
87* lipoprotein metabolic process (GO:0042157)3.23283991
88planar cell polarity pathway involved in neural tube closure (GO:0090179)3.23126530
89positive regulation of lipid catabolic process (GO:0050996)3.22880047
90serine family amino acid catabolic process (GO:0009071)3.22550500
91cellular modified amino acid catabolic process (GO:0042219)3.21507125
92glycine metabolic process (GO:0006544)3.20343476
93gap junction assembly (GO:0016264)3.19604923
94response to lipoprotein particle (GO:0055094)3.19389768
95* cholesterol homeostasis (GO:0042632)3.19244316
96negative regulation of fatty acid transport (GO:2000192)3.17040931
97* sterol homeostasis (GO:0055092)3.15900760
98positive regulation of fatty acid beta-oxidation (GO:0032000)3.14908528
99sterol biosynthetic process (GO:0016126)3.14481580
100progesterone metabolic process (GO:0042448)3.10391000
101positive regulation of lipoprotein lipase activity (GO:0051006)3.08731228
102positive regulation of triglyceride lipase activity (GO:0061365)3.08731228
103very-low-density lipoprotein particle assembly (GO:0034379)3.08382729
104drug catabolic process (GO:0042737)3.08218216
105amino-acid betaine metabolic process (GO:0006577)3.07059781
106imidazole-containing compound metabolic process (GO:0052803)3.07009058
107alpha-amino acid catabolic process (GO:1901606)3.06042278
108blood vessel endothelial cell migration (GO:0043534)3.05186459
109regulation of cholesterol metabolic process (GO:0090181)3.04691787
110cofactor catabolic process (GO:0051187)3.04402533
111glucuronate metabolic process (GO:0019585)3.04327623
112uronic acid metabolic process (GO:0006063)3.04327623
113basement membrane organization (GO:0071711)3.03654402
114regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.03227399
115COPI coating of Golgi vesicle (GO:0048205)3.02736866
116Golgi transport vesicle coating (GO:0048200)3.02736866
117regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.01604179
118positive regulation of fatty acid biosynthetic process (GO:0045723)3.01420067
119adherens junction assembly (GO:0034333)3.00474370
120acetyl-CoA metabolic process (GO:0006084)3.00172822
121Leydig cell differentiation (GO:0033327)2.98041750
122positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.97806932
123plasma lipoprotein particle organization (GO:0071827)2.97788693
124chemical homeostasis within a tissue (GO:0048875)2.97152255
125serine family amino acid biosynthetic process (GO:0009070)2.97147713
126* cholesterol metabolic process (GO:0008203)2.97063683
127semaphorin-plexin signaling pathway (GO:0071526)2.96248189
128acute-phase response (GO:0006953)2.96211603
129negative regulation of fatty acid biosynthetic process (GO:0045717)2.96194714
130protein-lipid complex subunit organization (GO:0071825)2.96006656
131aldehyde catabolic process (GO:0046185)2.95152340
132serine family amino acid metabolic process (GO:0009069)2.93939368
133ethanol oxidation (GO:0006069)2.93931542
134epoxygenase P450 pathway (GO:0019373)2.93479405
135indolalkylamine metabolic process (GO:0006586)2.93143489
136regulation of plasminogen activation (GO:0010755)2.91220701
137regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.87841140
138dicarboxylic acid biosynthetic process (GO:0043650)2.87190408
139cell-substrate adherens junction assembly (GO:0007045)2.87092005
140focal adhesion assembly (GO:0048041)2.87092005
141regulation of cholesterol storage (GO:0010885)2.87079731
142linoleic acid metabolic process (GO:0043651)2.86908600
143lysine catabolic process (GO:0006554)2.86606701
144lysine metabolic process (GO:0006553)2.86606701
145positive regulation of osteoblast proliferation (GO:0033690)2.86225837
146glutamate metabolic process (GO:0006536)2.86094353
147fatty acid elongation (GO:0030497)2.85151789
148polarized epithelial cell differentiation (GO:0030859)2.84220453
149lung vasculature development (GO:0060426)2.75541714
150endodermal cell differentiation (GO:0035987)2.73664546
151positive regulation of hormone metabolic process (GO:0032352)2.72632014
152wound healing, spreading of epidermal cells (GO:0035313)2.72314267
153protein localization to endosome (GO:0036010)2.71260532
154wound healing, spreading of cells (GO:0044319)2.71010401
155notochord development (GO:0030903)2.69993772
156hippo signaling (GO:0035329)2.69366000
157branching involved in mammary gland duct morphogenesis (GO:0060444)2.68057315
158keratinocyte proliferation (GO:0043616)2.67099906
159activation of Rac GTPase activity (GO:0032863)2.66539677
160regulation of water loss via skin (GO:0033561)2.63466333
161cytoskeletal anchoring at plasma membrane (GO:0007016)2.63445042
162endothelial cell morphogenesis (GO:0001886)2.63239151
163C21-steroid hormone metabolic process (GO:0008207)2.55986688
164branching involved in salivary gland morphogenesis (GO:0060445)2.54047899
165retina vasculature morphogenesis in camera-type eye (GO:0061299)2.53999490
166maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.51726164
167trophoblast giant cell differentiation (GO:0060707)2.46764948
168mammary gland development (GO:0030879)2.45455028
169substrate-dependent cell migration (GO:0006929)2.45334823
170Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.44149869
171neural crest cell development (GO:0014032)2.37010279
172positive regulation of p38MAPK cascade (GO:1900745)2.36401698
173regulation of establishment of planar polarity (GO:0090175)2.34483075
174glomerular visceral epithelial cell development (GO:0072015)2.34177747
175ER overload response (GO:0006983)2.33969535
176adhesion of symbiont to host (GO:0044406)2.33462210
177cell junction assembly (GO:0034329)2.31894294
178* low-density lipoprotein particle clearance (GO:0034383)2.31681497
179positive regulation of male gonad development (GO:2000020)2.31321748
180chondrocyte proliferation (GO:0035988)2.30809633
181COPII vesicle coating (GO:0048208)2.30018129
182G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.28343203
183mating behavior (GO:0007617)2.27245077
184* sterol metabolic process (GO:0016125)2.26278778
185hormone biosynthetic process (GO:0042446)2.26254739
186establishment of skin barrier (GO:0061436)2.26070508
187negative regulation of catenin import into nucleus (GO:0035414)2.24182815
188nuclear envelope reassembly (GO:0031468)2.23865427
189mitotic nuclear envelope reassembly (GO:0007084)2.23865427
190smooth muscle tissue development (GO:0048745)2.23824850
191vascular endothelial growth factor signaling pathway (GO:0038084)2.21756702
192cellular response to toxic substance (GO:0097237)2.20788357
193negative regulation of cartilage development (GO:0061037)2.20249489
194placenta blood vessel development (GO:0060674)2.19985876
195facial nerve structural organization (GO:0021612)2.19950492
196UDP-N-acetylglucosamine metabolic process (GO:0006047)2.19078134
197regulation of G0 to G1 transition (GO:0070316)2.18822897

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.24128151
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.92145630
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.23537958
4* LXR_22158963_ChIP-Seq_LIVER_Mouse4.83807832
5TP63_17297297_ChIP-ChIP_HaCaT_Human4.46034296
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.14637626
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.51174155
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.35421648
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.32995602
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.99911600
11CLOCK_20551151_ChIP-Seq_293T_Human2.60300613
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.51774600
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.42317196
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.37051607
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.36958823
16CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.36075558
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.21479489
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.03612486
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.99808180
20TRIM28_21343339_ChIP-Seq_HEK293_Human1.95347561
21* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.77783784
22AR_21909140_ChIP-Seq_LNCAP_Human1.73838237
23* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.72360933
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.72133728
25IRF8_22096565_ChIP-ChIP_GC-B_Human1.64839861
26TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64537321
27* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.63148668
28TP53_22127205_ChIP-Seq_IMR90_Human1.61619826
29ZNF263_19887448_ChIP-Seq_K562_Human1.56973024
30STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.54754340
31ZNF217_24962896_ChIP-Seq_MCF-7_Human1.54670683
32FOXO3_23340844_ChIP-Seq_DLD1_Human1.54198834
33* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.53915360
34CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.51276873
35* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.48881678
36ESR1_21235772_ChIP-Seq_MCF-7_Human1.48769162
37* FOXA2_19822575_ChIP-Seq_HepG2_Human1.48004767
38HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.47498950
39TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.47416719
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.46267106
41GATA1_22025678_ChIP-Seq_K562_Human1.45826794
42Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.43537358
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.41576147
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.41176418
45SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.39717240
46EGR1_19374776_ChIP-ChIP_THP-1_Human1.39318930
47PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.38098681
48RUNX1_27514584_Chip-Seq_MCF-7_Human1.37774381
49* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.36694672
50* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.33587221
51HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.33313014
52RACK7_27058665_Chip-Seq_MCF-7_Human1.32172614
53* GATA4_25053715_ChIP-Seq_YYC3_Human1.28526785
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.28402825
55WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.27200950
56NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26376499
57KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24341061
58* GATA6_25053715_ChIP-Seq_YYC3_Human1.23759581
59EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21574278
60RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20946531
61KDM2B_26808549_Chip-Seq_K562_Human1.20675480
62* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20574792
63SALL4_18804426_ChIP-ChIP_XEN_Mouse1.19405000
64ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19053052
65* ATF3_27146783_Chip-Seq_COLON_Human1.18695515
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17990820
67KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.17253899
68PPAR_26484153_Chip-Seq_NCI-H1993_Human1.15774717
69BRD4_27068464_Chip-Seq_AML-cells_Mouse1.14243624
70* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13455262
71LXR_22292898_ChIP-Seq_THP-1_Human1.12894677
72SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.12213645
73SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11307764
74AHR_22903824_ChIP-Seq_MCF-7_Human1.10648917
75SOX2_20726797_ChIP-Seq_SW620_Human1.09392743
76IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08865552
77ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08449177
78ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07826943
79* HNF4A_19822575_ChIP-Seq_HepG2_Human1.07769249
80BRD4_25478319_ChIP-Seq_HGPS_Human1.07215964
81KLF5_25053715_ChIP-Seq_YYC3_Human1.07051707
82ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06000436
83FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.05945056
84GATA1_19941826_ChIP-Seq_K562_Human1.05734707
85NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.04942666
86EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03855418
87P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02217006
88SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01055499
89SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00819463
90SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00819463
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00282863
92CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99610261
93* FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.98500135
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98071536
95KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97514593
96TP53_23651856_ChIP-Seq_MEFs_Mouse0.97010172
97E2F7_22180533_ChIP-Seq_HELA_Human0.96499603
98* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96400452
99NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.95172336
100CHD1_26751641_Chip-Seq_LNCaP_Human0.94561980
101MYB_21317192_ChIP-Seq_ERMYB_Mouse0.94146733
102KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93893885
103CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93498240
104* CREB1_26743006_Chip-Seq_LNCaP_Human0.93310925
105IRF8_27001747_Chip-Seq_BMDM_Mouse0.92967256
106TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92133319
107AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.90717872
108PKCTHETA_26484144_Chip-Seq_BREAST_Human0.90488407
109PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89673532
110TBX20_22080862_ChIP-Seq_HEART_Mouse0.88790140
111TBX20_22328084_ChIP-Seq_HEART_Mouse0.88790140
112SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87138090
113POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.86685527
114NFIB_24661679_ChIP-Seq_LUNG_Mouse0.85204084
115NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85066919
116NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85066919
117CDX2_20551321_ChIP-Seq_CACO-2_Human0.84245295
118STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81544544
119FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.81408632
120* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.81116047
121FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.80307075
122TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80211916
123KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.79499361
124* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79398670
125GATA3_24758297_ChIP-Seq_MCF-7_Human0.79187792
126GATA2_21666600_ChIP-Seq_HMVEC_Human0.78083528
127UBF1/2_26484160_Chip-Seq_HMECs_Human0.76676307
128TCF3_18692474_ChIP-Seq_MEFs_Mouse0.76398710
129* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74582082
130GATA2_19941826_ChIP-Seq_K562_Human0.74115494
131* CJUN_26792858_Chip-Seq_BT549_Human0.73424575
132SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.72786713
133IRF8_21731497_ChIP-ChIP_J774_Mouse0.72456608
134* NCOR1_26117541_ChIP-Seq_K562_Human0.71078226
135TCF7_22412390_ChIP-Seq_EML_Mouse0.70682707
136ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.70532111
137* KDM2B_26808549_Chip-Seq_DND41_Human0.70208456
138* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.69340747

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.39720854
2MP0005360_urolithiasis5.41200402
3MP0005085_abnormal_gallbladder_physiolo4.61463551
4MP0005365_abnormal_bile_salt4.41901095
5MP0003806_abnormal_nucleotide_metabolis3.52341025
6MP0008875_abnormal_xenobiotic_pharmacok3.36298709
7MP0003705_abnormal_hypodermis_morpholog3.36204602
8MP0003252_abnormal_bile_duct3.24658680
9MP0003950_abnormal_plasma_membrane2.89405448
10* MP0009840_abnormal_foam_cell2.78595358
11MP0003195_calcinosis2.65051507
12MP0010329_abnormal_lipoprotein_level2.64583155
13MP0003941_abnormal_skin_development2.62820924
14MP0010030_abnormal_orbit_morphology2.34957350
15MP0008438_abnormal_cutaneous_collagen2.23747367
16MP0000537_abnormal_urethra_morphology2.10984723
17MP0001666_abnormal_nutrient_absorption2.10495904
18MP0000566_synostosis2.08509652
19MP0000762_abnormal_tongue_morphology2.06503907
20* MP0005083_abnormal_biliary_tract2.02202920
21MP0005409_darkened_coat_color2.01504515
22MP0002877_abnormal_melanocyte_morpholog1.99208735
23* MP0000609_abnormal_liver_physiology1.84454629
24MP0003300_gastrointestinal_ulcer1.80033204
25MP0003191_abnormal_cellular_cholesterol1.79840208
26MP0002138_abnormal_hepatobiliary_system1.77156640
27* MP0002118_abnormal_lipid_homeostasis1.71173386
28MP0003566_abnormal_cell_adhesion1.63659950
29MP0004782_abnormal_surfactant_physiolog1.62295784
30MP0000383_abnormal_hair_follicle1.61863681
31MP0003868_abnormal_feces_composition1.56494866
32* MP0005332_abnormal_amino_acid1.56116697
33MP0002089_abnormal_postnatal_growth/wei1.52284964
34MP0002254_reproductive_system_inflammat1.49875072
35MP0004233_abnormal_muscle_weight1.49260518
36MP0005058_abnormal_lysosome_morphology1.48102328
37MP0005408_hypopigmentation1.44331513
38MP0005275_abnormal_skin_tensile1.43182372
39MP0002098_abnormal_vibrissa_morphology1.42517328
40MP0010352_gastrointestinal_tract_polyps1.42227555
41MP0000678_abnormal_parathyroid_gland1.41767929
42MP0005257_abnormal_intraocular_pressure1.37232180
43MP0003315_abnormal_perineum_morphology1.36908839
44MP0010234_abnormal_vibrissa_follicle1.33678470
45MP0005623_abnormal_meninges_morphology1.33651300
46MP0005319_abnormal_enzyme/_coenzyme1.29299360
47MP0010771_integument_phenotype1.27507189
48MP0003453_abnormal_keratinocyte_physiol1.26335627
49MP0005023_abnormal_wound_healing1.24433555
50MP0004019_abnormal_vitamin_homeostasis1.23384360
51MP0003436_decreased_susceptibility_to1.22272165
52MP0000534_abnormal_ureter_morphology1.19161429
53MP0002060_abnormal_skin_morphology1.17842565
54MP0003755_abnormal_palate_morphology1.17464866
55MP0005508_abnormal_skeleton_morphology1.15263345
56MP0009643_abnormal_urine_homeostasis1.14965749
57* MP0000598_abnormal_liver_morphology1.13576792
58MP0002796_impaired_skin_barrier1.08238594
59MP0003283_abnormal_digestive_organ1.05577734
60MP0005076_abnormal_cell_differentiation1.05521221
61MP0001879_abnormal_lymphatic_vessel1.05509744
62MP0005220_abnormal_exocrine_pancreas1.05433911
63MP0002086_abnormal_extraembryonic_tissu1.01690550
64* MP0004947_skin_inflammation1.00837650
65MP0004264_abnormal_extraembryonic_tissu0.99875047
66MP0001958_emphysema0.96106128
67MP0005451_abnormal_body_composition0.95768269
68MP0004858_abnormal_nervous_system0.95703920
69MP0002697_abnormal_eye_size0.95503736
70MP0002282_abnormal_trachea_morphology0.95437782
71MP0003937_abnormal_limbs/digits/tail_de0.94465521
72MP0003303_peritoneal_inflammation0.94357742
73MP0002111_abnormal_tail_morphology0.94247892
74MP0003115_abnormal_respiratory_system0.93898626
75MP0003984_embryonic_growth_retardation0.93686740
76MP0000767_abnormal_smooth_muscle0.93393223
77MP0001299_abnormal_eye_distance/0.92830101
78MP0009763_increased_sensitivity_to0.91168485
79MP0002088_abnormal_embryonic_growth/wei0.91118201
80MP0000013_abnormal_adipose_tissue0.90631542
81MP0008007_abnormal_cellular_replicative0.90383433
82MP0002925_abnormal_cardiovascular_devel0.90284138
83MP0005584_abnormal_enzyme/coenzyme_acti0.89730368
84MP0003942_abnormal_urinary_system0.89021065
85MP0009053_abnormal_anal_canal0.88788341
86* MP0001243_abnormal_dermal_layer0.86737043
87MP0005380_embryogenesis_phenotype0.86560102
88MP0001672_abnormal_embryogenesis/_devel0.86560102
89MP0004197_abnormal_fetal_growth/weight/0.86332051
90MP0003935_abnormal_craniofacial_develop0.85508959
91MP0004272_abnormal_basement_membrane0.85494991
92* MP0009931_abnormal_skin_appearance0.84616957
93MP0003091_abnormal_cell_migration0.84608564
94MP0003172_abnormal_lysosome_physiology0.84484690
95MP0005621_abnormal_cell_physiology0.82435040
96MP0003693_abnormal_embryo_hatching0.82386310
97* MP0005197_abnormal_uvea_morphology0.82001732
98MP0009384_cardiac_valve_regurgitation0.81885907
99MP0004185_abnormal_adipocyte_glucose0.81617230
100MP0000627_abnormal_mammary_gland0.81186930
101MP0000432_abnormal_head_morphology0.80962833
102MP0000751_myopathy0.80857343
103MP0002896_abnormal_bone_mineralization0.80319790
104MP0008932_abnormal_embryonic_tissue0.80216663
105MP0002084_abnormal_developmental_patter0.80194372
106MP0005464_abnormal_platelet_physiology0.79928990
107MP0003943_abnormal_hepatobiliary_system0.78991674
108MP0001533_abnormal_skeleton_physiology0.78952426
109MP0003385_abnormal_body_wall0.77993344
110MP0001348_abnormal_lacrimal_gland0.76688159
111MP0001849_ear_inflammation0.76416370
112MP0002168_other_aberrant_phenotype0.75646663
113* MP0001614_abnormal_blood_vessel0.74678012
114* MP0008469_abnormal_protein_level0.74314083
115MP0006138_congestive_heart_failure0.74125320
116MP0002234_abnormal_pharynx_morphology0.73915681
117* MP0000604_amyloidosis0.73573895
118MP0009780_abnormal_chondrocyte_physiolo0.73250611
119MP0000733_abnormal_muscle_development0.73125596
120MP0001944_abnormal_pancreas_morphology0.73123496
121MP0000538_abnormal_urinary_bladder0.72606589
122MP0003786_premature_aging0.72420027
123MP0002909_abnormal_adrenal_gland0.72328090
124MP0000428_abnormal_craniofacial_morphol0.71946788
125MP0000462_abnormal_digestive_system0.71864153
126MP0002085_abnormal_embryonic_tissue0.71838676
127MP0002295_abnormal_pulmonary_circulatio0.71508569
128* MP0002078_abnormal_glucose_homeostasis0.71230663
129MP0003656_abnormal_erythrocyte_physiolo0.71169505
130* MP0002080_prenatal_lethality0.70986017
131MP0003186_abnormal_redox_activity0.68958840
132MP0001216_abnormal_epidermal_layer0.68551076
133MP0006082_CNS_inflammation0.66645197
134MP0003279_aneurysm0.65238516
135* MP0009642_abnormal_blood_homeostasis0.63757816
136MP0003045_fibrosis0.63204417
137MP0010678_abnormal_skin_adnexa0.63070906
138MP0000467_abnormal_esophagus_morphology0.61972728
139MP0010368_abnormal_lymphatic_system0.61746338
140MP0002928_abnormal_bile_duct0.61113169
141MP0002693_abnormal_pancreas_physiology0.60584516
142MP0003690_abnormal_glial_cell0.59667830
143MP0001881_abnormal_mammary_gland0.58927384
144MP0001661_extended_life_span0.58785392
145MP0001756_abnormal_urination0.58369984
146MP0009764_decreased_sensitivity_to0.58186693
147MP0003075_altered_response_to0.58138673
148MP0006054_spinal_hemorrhage0.57403600
149MP0000377_abnormal_hair_follicle0.57366070
150MP0001764_abnormal_homeostasis0.57317399
151MP0000579_abnormal_nail_morphology0.56867157
152MP0009672_abnormal_birth_weight0.56183977
153MP0005501_abnormal_skin_physiology0.55666918
154MP0005164_abnormal_response_to0.54374624
155MP0003724_increased_susceptibility_to0.53498527
156MP0009765_abnormal_xenobiotic_induced0.52701004
157MP0000003_abnormal_adipose_tissue0.52542732
158MP0005248_abnormal_Harderian_gland0.52035426
159MP0001915_intracranial_hemorrhage0.50912855
160MP0005375_adipose_tissue_phenotype0.49013658
161MP0002933_joint_inflammation0.48108026

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.10162449
2Deep venous thrombosis (HP:0002625)5.96790489
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.69215550
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.37791959
5* Xanthomatosis (HP:0000991)4.88587238
6Hypobetalipoproteinemia (HP:0003563)4.43717781
7Prolonged partial thromboplastin time (HP:0003645)4.42015913
8Atrophic scars (HP:0001075)4.04095219
9Abnormality of the common coagulation pathway (HP:0010990)3.94567695
10Milia (HP:0001056)3.84521554
11Hypoglycemic coma (HP:0001325)3.82836162
12Complement deficiency (HP:0004431)3.76170047
13Hyperlipoproteinemia (HP:0010980)3.72409439
14Hypolipoproteinemia (HP:0010981)3.48151881
15Joint hemorrhage (HP:0005261)3.47778972
16Short nail (HP:0001799)3.37608168
17Myocardial infarction (HP:0001658)3.35553583
18Abnormality of glutamine family amino acid metabolism (HP:0010902)3.33157532
19Peritonitis (HP:0002586)3.30083749
20Hypoglycemic seizures (HP:0002173)3.29293351
21Fragile nails (HP:0001808)3.28587862
22Fat malabsorption (HP:0002630)3.25162439
23Abnormality of the intrinsic pathway (HP:0010989)3.23309795
24Abnormality of sulfur amino acid metabolism (HP:0004339)3.20666128
25Hypoalphalipoproteinemia (HP:0003233)3.17466702
26Onycholysis (HP:0001806)3.16923329
27Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.16538105
28Hyperinsulinemic hypoglycemia (HP:0000825)3.14265602
29Abnormality of complement system (HP:0005339)3.07704471
30Fragile skin (HP:0001030)3.02483632
31Broad face (HP:0000283)3.00529006
32Thick nail (HP:0001805)2.99980904
33Conjugated hyperbilirubinemia (HP:0002908)2.93661324
34Natal tooth (HP:0000695)2.92513828
35Alopecia of scalp (HP:0002293)2.91220713
36Hypercholesterolemia (HP:0003124)2.88840476
37Plantar hyperkeratosis (HP:0007556)2.85464939
38Abnormality of methionine metabolism (HP:0010901)2.84741401
39Bronchomalacia (HP:0002780)2.82994158
40Ketosis (HP:0001946)2.82864189
41Abnormality of nail color (HP:0100643)2.76710812
42Arterial tortuosity (HP:0005116)2.75948321
43Premature rupture of membranes (HP:0001788)2.67806334
44Hyperammonemia (HP:0001987)2.64772798
45Turricephaly (HP:0000262)2.63791126
46* Epidermoid cyst (HP:0200040)2.62474463
47Shallow orbits (HP:0000586)2.61908412
48Pterygium (HP:0001059)2.61495120
49Abnormality of aspartate family amino acid metabolism (HP:0010899)2.59231812
50Esophageal varix (HP:0002040)2.56552244
51Vascular tortuosity (HP:0004948)2.51475005
52Advanced eruption of teeth (HP:0006288)2.48211896
53Breast hypoplasia (HP:0003187)2.47092215
54Spastic diplegia (HP:0001264)2.46877389
55Mitral stenosis (HP:0001718)2.42456447
56Right ventricular cardiomyopathy (HP:0011663)2.39349868
57Nail dystrophy (HP:0008404)2.39241503
58Abnormality of pyrimidine metabolism (HP:0004353)2.39074876
59Symptomatic seizures (HP:0011145)2.38553108
60Increased mean platelet volume (HP:0011877)2.38340154
61Hepatocellular carcinoma (HP:0001402)2.36151555
62Abnormality of the nasal septum (HP:0000419)2.33153995
63Systemic lupus erythematosus (HP:0002725)2.33050155
64Hypoplasia of dental enamel (HP:0006297)2.30483948
65Ketoacidosis (HP:0001993)2.29247441
66Hyperacusis (HP:0010780)2.26755486
67Protrusio acetabuli (HP:0003179)2.25491458
68Steatorrhea (HP:0002570)2.25220718
69Abnormality of carpal bone ossification (HP:0006257)2.22925245
7011 pairs of ribs (HP:0000878)2.22758646
71Hyperglycemia (HP:0003074)2.21822716
72Hyperglycinemia (HP:0002154)2.21224704
73Bowing of the arm (HP:0006488)2.20467577
74Bowed forearm bones (HP:0003956)2.20467577
75Popliteal pterygium (HP:0009756)2.19722909
76Renal salt wasting (HP:0000127)2.19399588
77Selective tooth agenesis (HP:0001592)2.19220456
78Abnormality of nucleobase metabolism (HP:0010932)2.19049877
79* Skin nodule (HP:0200036)2.19004652
80Deviation of the thumb (HP:0009603)2.18507017
81Recurrent gram-negative bacterial infections (HP:0005420)2.16497073
82Late onset (HP:0003584)2.16360986
83Abnormality of the distal phalanx of the thumb (HP:0009617)2.16148125
84Menorrhagia (HP:0000132)2.15965848
85Abnormality of endocrine pancreas physiology (HP:0012093)2.14058215
86Abnormality of the pancreatic islet cells (HP:0006476)2.14058215
87Abnormal enzyme/coenzyme activity (HP:0012379)2.13774626
88Bladder diverticulum (HP:0000015)2.12547480
89Protuberant abdomen (HP:0001538)2.11906552
90Amyloidosis (HP:0011034)2.11088166
91Axonal loss (HP:0003447)2.10958308
92Hyperbilirubinemia (HP:0002904)2.10061678
93Abnormality of purine metabolism (HP:0004352)2.09037377
94Abnormal ossification of hand bones (HP:0005921)2.08780230
95Abnormality of glycine metabolism (HP:0010895)2.08731974
96Abnormality of serine family amino acid metabolism (HP:0010894)2.08731974
97Abnormal cartilage morphology (HP:0002763)2.07803945
98Hemorrhage of the eye (HP:0011885)2.06402866
99Coronal craniosynostosis (HP:0004440)2.06354365
100Elevated alkaline phosphatase (HP:0003155)2.06343842
101Abnormal platelet volume (HP:0011876)2.04316885
102Back pain (HP:0003418)2.03279499
103Ridged nail (HP:0001807)2.00485544
104Ankyloglossia (HP:0010296)2.00438399
105Ureteral duplication (HP:0000073)2.00413058
106Palmoplantar hyperkeratosis (HP:0000972)2.00303962
107Abnormality of proline metabolism (HP:0010907)1.98710842
108Hydroxyprolinuria (HP:0003080)1.98710842
109Abnormality of alkaline phosphatase activity (HP:0004379)1.98000212
110Urinary glycosaminoglycan excretion (HP:0003541)1.97582262
111Mucopolysacchariduria (HP:0008155)1.97582262
112Ankle contracture (HP:0006466)1.97315682
113Cerebral inclusion bodies (HP:0100314)1.97304379
114Acanthocytosis (HP:0001927)1.97176557
115Abdominal distention (HP:0003270)1.96940854
116Gingival bleeding (HP:0000225)1.96767472
117Disproportionate tall stature (HP:0001519)1.96507892
118Glomerulonephritis (HP:0000099)1.95146977
119Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.94891192
120Ulnar bowing (HP:0003031)1.94546291
121Facial hemangioma (HP:0000329)1.94243633
122Abnormality of the distal phalanges of the toes (HP:0010182)1.92799271
123Cardiovascular calcification (HP:0011915)1.92288674
124Wormian bones (HP:0002645)1.91954785
125Spinal rigidity (HP:0003306)1.91596984
126Peripheral demyelination (HP:0011096)1.90409229
127Abnormal gallbladder morphology (HP:0012437)1.89699600
128Pancreatic islet-cell hyperplasia (HP:0004510)1.89392902
129Vascular calcification (HP:0004934)1.88837332
130Neurofibrillary tangles (HP:0002185)1.88393714
131Tibial bowing (HP:0002982)1.87958042
132Irritability (HP:0000737)1.87637681
133Follicular hyperkeratosis (HP:0007502)1.87207314
134Capillary hemangiomas (HP:0005306)1.86684128
135Neonatal short-limb short stature (HP:0008921)1.85964219
136Increased number of teeth (HP:0011069)1.85023280
137Palmar hyperkeratosis (HP:0010765)1.84883905
138Abnormality of oral frenula (HP:0000190)1.84098782
139Absent eyelashes (HP:0000561)1.82733652
140Vertebral hypoplasia (HP:0008417)1.81627741
141Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.81627741
142Abnormality of transition element cation homeostasis (HP:0011030)1.80932919
143Pseudobulbar signs (HP:0002200)1.80585522
144Septate vagina (HP:0001153)1.80528746
145Heterotopia (HP:0002282)1.80481209
146Abnormality of the Achilles tendon (HP:0005109)1.79234313
147Short humerus (HP:0005792)1.79010112
148Aortic dissection (HP:0002647)1.78936363
149Osteolytic defects of the phalanges of the hand (HP:0009771)1.77921519
150Osteolytic defects of the hand bones (HP:0009699)1.77921519
151Hyperglycinuria (HP:0003108)1.77488222
152Abnormality of iron homeostasis (HP:0011031)1.77376832
153Abnormality of mucopolysaccharide metabolism (HP:0011020)1.76817932
154Abnormality of polysaccharide metabolism (HP:0011012)1.76817932
155Abnormality of glycosaminoglycan metabolism (HP:0004371)1.76817932
156Cervical subluxation (HP:0003308)1.76610049
157Ectopia lentis (HP:0001083)1.75939266
158Vertebral clefting (HP:0008428)1.74524202
159Flat acetabular roof (HP:0003180)1.73141365
160Tracheal stenosis (HP:0002777)1.72836096
161Vertebral arch anomaly (HP:0008438)1.71978230
162Nephritis (HP:0000123)1.71584560
163Interstitial pulmonary disease (HP:0006530)1.70260139
164Aplasia of the phalanges of the hand (HP:0009802)1.69730240
165Aplasia involving bones of the extremities (HP:0009825)1.69730240
166Aplasia involving bones of the upper limbs (HP:0009823)1.69730240
167Thin bony cortex (HP:0002753)1.69611821
168Cerebral aneurysm (HP:0004944)1.69609849
169Morphological abnormality of the middle ear (HP:0008609)1.67198463
170Lip pit (HP:0100267)1.66725009
171Focal segmental glomerulosclerosis (HP:0000097)1.66569079
172Proximal placement of thumb (HP:0009623)1.64273535
173Blue sclerae (HP:0000592)1.63513706
174Abnormal hand bone ossification (HP:0010660)1.63136216
175Elbow flexion contracture (HP:0002987)1.60641036
176Long palpebral fissure (HP:0000637)1.60330989
177Soft skin (HP:0000977)1.59085669
178Aortic aneurysm (HP:0004942)1.58958990
179Entropion (HP:0000621)1.58603918
180Difficulty climbing stairs (HP:0003551)1.57126496
181Oligodontia (HP:0000677)1.55813886
182Missing ribs (HP:0000921)1.55293201
183Laryngomalacia (HP:0001601)1.55072356
184Trismus (HP:0000211)1.54698554
185Distal lower limb amyotrophy (HP:0008944)1.54206292
186Upper limb muscle weakness (HP:0003484)1.53438127
187Aplasia/hypoplasia of the humerus (HP:0006507)1.53104283
188Poikiloderma (HP:0001029)1.53030256
189Overlapping toe (HP:0001845)1.51334288

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.73766794
2SIK13.38007504
3TRIB33.36227302
4PKN22.85894542
5EPHB12.70024473
6FGFR42.56327547
7MET2.54268900
8EPHA22.36535877
9INSRR2.30064109
10PTK62.26889429
11MST1R2.15199712
12FLT32.15087122
13TAOK32.12215864
14LMTK22.10257200
15PIM21.97984344
16BMX1.91195082
17LATS11.88664660
18LATS21.85130468
19PTK21.83042477
20TSSK61.79009030
21PDGFRA1.73812303
22SMG11.66361401
23ERBB41.62127024
24MAP3K101.61347394
25EPHA31.58184147
26RIPK11.41198322
27TTN1.40882991
28TYK21.40561485
29AKT31.39983173
30MAP3K21.39431469
31NTRK11.32283475
32EEF2K1.32135240
33BCKDK1.30135580
34CAMK1D1.29474805
35DDR21.28142223
36TBK11.26883078
37PASK1.26753639
38FRK1.24605204
39LRRK21.21215380
40MAPK151.20033789
41CDK121.19294461
42MAP2K21.16673093
43MAP3K31.11617562
44SCYL21.11188410
45MTOR1.08054672
46FGFR21.06718104
47BRSK21.05221983
48JAK11.04307854
49MELK0.97656625
50MAP3K90.95430394
51PDGFRB0.94114016
52ICK0.94084807
53PIK3CG0.93711518
54MAP3K140.92787080
55WEE10.91170358
56CSK0.88982266
57MAP3K10.88408467
58RET0.88376977
59STK100.87715799
60PAK20.87455671
61WNK40.87094030
62JAK20.86525447
63JAK30.86274156
64NEK20.83130343
65GSK3A0.81731165
66DYRK1B0.81658914
67CDK60.79733110
68NEK90.79448886
69CAMK1G0.79043802
70CHUK0.77556073
71STK30.77199501
72RPS6KA20.76453180
73CDK70.74537949
74PBK0.73886104
75ERBB20.73845698
76CDK80.71705326
77KSR20.71236195
78FER0.70247085
79ABL20.69385971
80PAK30.68816012
81FGFR10.68549138
82TRPM70.68470892
83HIPK20.68030851
84TESK20.65319366
85MAP2K10.64458539
86PRKD20.63472487
87TGFBR10.62646040
88MAP3K80.62625765
89MAP2K30.60925621
90FGFR30.60326228
91TGFBR20.59963763
92PDK20.59856109
93MAPK110.58380861
94CLK10.58173736
95PNCK0.58124994
96TTK0.57678396
97CDC42BPA0.57073502
98MAP3K60.56816779
99PRKG20.56135541
100IKBKB0.55435730
101ALK0.54797304
102EGFR0.53700871
103STK380.53325493
104BLK0.52881348
105MOS0.50461849
106PAK40.50360507
107BRD40.49895215
108RAF10.49658627
109PRKAA20.47092374
110ZAP700.45734092
111TESK10.44989838
112FGR0.44614097
113PRKCI0.44291519
114WNK10.43834112
115CSF1R0.43216650
116TAOK20.42549144
117INSR0.42251487
118IRAK30.41977572
119AURKA0.40971026
120RPS6KB20.40656073
121DMPK0.40164501
122BRSK10.38543915
123IGF1R0.38459529
124EPHB20.37392646
125CHEK20.36899631
126MAP3K70.35661911
127PRKD10.35416404
128PRPF4B0.34798757
129ABL10.34257127
130MATK0.34109573
131MAPKAPK30.33957919
132RPS6KA10.33711665
133MAP3K110.33347163
134RPS6KA40.33089251
135MYLK0.33053189
136BUB10.32771481
137LIMK10.32200438
138ARAF0.31904301
139MARK20.31369330
140AKT20.31352484
141RPS6KC10.31257459
142RPS6KL10.31257459
143RPS6KA60.30450461
144MAPK10.30170468
145CDK90.30112245
146SRC0.29328913
147PDPK10.29259287
148STK38L0.27169823
149PRKAA10.26995840
150TIE10.26905666
151AURKB0.26494679
152CHEK10.26025879
153ADRBK10.25844413

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.70227452
2Nitrogen metabolism_Homo sapiens_hsa009103.41802383
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.08695676
4Steroid biosynthesis_Homo sapiens_hsa001002.88518332
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.72090503
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.62811047
7Arginine biosynthesis_Homo sapiens_hsa002202.57849447
8Tryptophan metabolism_Homo sapiens_hsa003802.55689239
9Complement and coagulation cascades_Homo sapiens_hsa046102.53380699
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.36257606
11Histidine metabolism_Homo sapiens_hsa003402.11781068
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.09826017
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.99205079
14Fatty acid degradation_Homo sapiens_hsa000711.98528007
15Pentose and glucuronate interconversions_Homo sapiens_hsa000401.95199126
16Caffeine metabolism_Homo sapiens_hsa002321.92918139
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.91912691
18Staphylococcus aureus infection_Homo sapiens_hsa051501.90186330
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.88834499
20Selenocompound metabolism_Homo sapiens_hsa004501.80304287
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.79890507
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.79817233
23Butanoate metabolism_Homo sapiens_hsa006501.78737700
24Sulfur metabolism_Homo sapiens_hsa009201.75432419
25Fatty acid metabolism_Homo sapiens_hsa012121.64571859
26Chemical carcinogenesis_Homo sapiens_hsa052041.59762774
27PPAR signaling pathway_Homo sapiens_hsa033201.58765643
28Hippo signaling pathway_Homo sapiens_hsa043901.54987286
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.54940417
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.54855793
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.51858943
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.51774384
33Peroxisome_Homo sapiens_hsa041461.51359418
34Phenylalanine metabolism_Homo sapiens_hsa003601.50903184
35MicroRNAs in cancer_Homo sapiens_hsa052061.49553787
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.44398879
37Fatty acid elongation_Homo sapiens_hsa000621.43790120
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.41727366
39Tyrosine metabolism_Homo sapiens_hsa003501.37125511
40Folate biosynthesis_Homo sapiens_hsa007901.36829033
41Fat digestion and absorption_Homo sapiens_hsa049751.35563958
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.34484127
43* Bile secretion_Homo sapiens_hsa049761.33225134
44* Ovarian steroidogenesis_Homo sapiens_hsa049131.32128382
45Retinol metabolism_Homo sapiens_hsa008301.30418648
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.29156351
47Starch and sucrose metabolism_Homo sapiens_hsa005001.23795374
48ABC transporters_Homo sapiens_hsa020101.22506358
49TGF-beta signaling pathway_Homo sapiens_hsa043501.21915029
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.18992843
51Thyroid cancer_Homo sapiens_hsa052161.18136850
52beta-Alanine metabolism_Homo sapiens_hsa004101.17466579
53N-Glycan biosynthesis_Homo sapiens_hsa005101.08061476
54Sphingolipid metabolism_Homo sapiens_hsa006001.07851566
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.05093961
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04784673
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01476813
58Basal cell carcinoma_Homo sapiens_hsa052171.00332866
59Propanoate metabolism_Homo sapiens_hsa006400.98534969
60Arginine and proline metabolism_Homo sapiens_hsa003300.97192770
61Tight junction_Homo sapiens_hsa045300.96887054
62One carbon pool by folate_Homo sapiens_hsa006700.96608573
63Lysine degradation_Homo sapiens_hsa003100.96295216
64Axon guidance_Homo sapiens_hsa043600.94605405
65Biosynthesis of amino acids_Homo sapiens_hsa012300.92869034
66Notch signaling pathway_Homo sapiens_hsa043300.90793439
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89324244
68PI3K-Akt signaling pathway_Homo sapiens_hsa041510.86774863
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83800332
70Sulfur relay system_Homo sapiens_hsa041220.82211101
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.81299079
72* Aldosterone synthesis and secretion_Homo sapiens_hsa049250.81145927
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.80598835
74Prostate cancer_Homo sapiens_hsa052150.79228492
75Pyruvate metabolism_Homo sapiens_hsa006200.79157694
76ErbB signaling pathway_Homo sapiens_hsa040120.79130312
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78580316
78Vitamin digestion and absorption_Homo sapiens_hsa049770.75897462
79Pathways in cancer_Homo sapiens_hsa052000.75686115
80p53 signaling pathway_Homo sapiens_hsa041150.74193252
81Carbon metabolism_Homo sapiens_hsa012000.73300498
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72821807
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72812631
84Endometrial cancer_Homo sapiens_hsa052130.68425250
85Other glycan degradation_Homo sapiens_hsa005110.68208955
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67316304
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.67304972
88Prion diseases_Homo sapiens_hsa050200.65598911
89Dilated cardiomyopathy_Homo sapiens_hsa054140.64683080
90Renal cell carcinoma_Homo sapiens_hsa052110.62418252
91Hedgehog signaling pathway_Homo sapiens_hsa043400.62209265
92Insulin resistance_Homo sapiens_hsa049310.62185875
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61939251
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.61419642
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60482150
96Fatty acid biosynthesis_Homo sapiens_hsa000610.59754389
97Pancreatic cancer_Homo sapiens_hsa052120.57915119
98Apoptosis_Homo sapiens_hsa042100.55844621
99Cell cycle_Homo sapiens_hsa041100.54526471
100Lysosome_Homo sapiens_hsa041420.53879539
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53146881
102Pentose phosphate pathway_Homo sapiens_hsa000300.52709365
103Bladder cancer_Homo sapiens_hsa052190.50688549
104Glutathione metabolism_Homo sapiens_hsa004800.49601317
105Insulin signaling pathway_Homo sapiens_hsa049100.49472964
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.48486696
107Glycosaminoglycan degradation_Homo sapiens_hsa005310.48351920
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48215449
109Thyroid hormone synthesis_Homo sapiens_hsa049180.47968045
110Melanoma_Homo sapiens_hsa052180.46316558
111Wnt signaling pathway_Homo sapiens_hsa043100.46237441
112Amoebiasis_Homo sapiens_hsa051460.44070247
113Mineral absorption_Homo sapiens_hsa049780.42711110
114ECM-receptor interaction_Homo sapiens_hsa045120.42234883
115alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42054001
116Estrogen signaling pathway_Homo sapiens_hsa049150.42041109
117Glycerolipid metabolism_Homo sapiens_hsa005610.41270880
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40500750
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40302513
120Circadian rhythm_Homo sapiens_hsa047100.40279277
121VEGF signaling pathway_Homo sapiens_hsa043700.39924144
122Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38890293
123Galactose metabolism_Homo sapiens_hsa000520.37810269
124Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36812605
125Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36412814
126Viral carcinogenesis_Homo sapiens_hsa052030.34821920
127Linoleic acid metabolism_Homo sapiens_hsa005910.33274274
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.32331999
129Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28753086
130Malaria_Homo sapiens_hsa051440.28559966
131Type II diabetes mellitus_Homo sapiens_hsa049300.28137821
132Legionellosis_Homo sapiens_hsa051340.24693279
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24490130
134Proteoglycans in cancer_Homo sapiens_hsa052050.24255334
135Pertussis_Homo sapiens_hsa051330.21780149
136Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.21743655
137Focal adhesion_Homo sapiens_hsa045100.19652419
138Vitamin B6 metabolism_Homo sapiens_hsa007500.19131272
139AMPK signaling pathway_Homo sapiens_hsa041520.17941127
140Adherens junction_Homo sapiens_hsa045200.17800743
141Metabolic pathways_Homo sapiens_hsa011000.17621643
142Fructose and mannose metabolism_Homo sapiens_hsa000510.17349297
143Carbohydrate digestion and absorption_Homo sapiens_hsa049730.15855305
144Small cell lung cancer_Homo sapiens_hsa052220.14050417
145TNF signaling pathway_Homo sapiens_hsa046680.13619999
146Renin-angiotensin system_Homo sapiens_hsa046140.13407078
147Protein digestion and absorption_Homo sapiens_hsa049740.13338118
148Leishmaniasis_Homo sapiens_hsa051400.12165809
149Prolactin signaling pathway_Homo sapiens_hsa049170.11217792
150* Hepatitis C_Homo sapiens_hsa051600.10186227
151Chronic myeloid leukemia_Homo sapiens_hsa052200.09374849

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