LDLRAD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.87039205
2peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)7.79649140
3translational termination (GO:0006415)7.46122541
4ribosomal small subunit biogenesis (GO:0042274)7.38241519
5ribosomal small subunit assembly (GO:0000028)6.36916703
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.33814867
7cotranslational protein targeting to membrane (GO:0006613)6.24115637
8protein targeting to ER (GO:0045047)6.18229083
9maturation of SSU-rRNA (GO:0030490)6.08865348
10translational elongation (GO:0006414)6.06961917
11relaxation of smooth muscle (GO:0044557)5.91061789
12negative regulation of complement activation (GO:0045916)5.88429396
13establishment of protein localization to endoplasmic reticulum (GO:0072599)5.86102830
14notochord development (GO:0030903)5.84506897
15protein localization to endoplasmic reticulum (GO:0070972)5.79554988
16endothelium development (GO:0003158)5.65299042
17viral life cycle (GO:0019058)5.47259732
18cellular protein complex disassembly (GO:0043624)5.41739364
19nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.18245707
20cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.85664727
21negative regulation of protein activation cascade (GO:2000258)4.85130133
22negative regulation of keratinocyte proliferation (GO:0010839)4.84852116
23mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.81235346
24translational initiation (GO:0006413)4.77348739
25lymphangiogenesis (GO:0001946)4.72751047
26lymph vessel development (GO:0001945)4.69796661
27keratan sulfate catabolic process (GO:0042340)4.56044720
28cartilage condensation (GO:0001502)4.49951859
29cell aggregation (GO:0098743)4.49951859
30heart contraction (GO:0060047)4.49776202
31heart process (GO:0003015)4.49776202
32protein complex disassembly (GO:0043241)4.48213428
33dermatan sulfate biosynthetic process (GO:0030208)4.44253339
34chondroitin sulfate biosynthetic process (GO:0030206)4.36340929
35bone trabecula formation (GO:0060346)4.31556580
36cell proliferation involved in kidney development (GO:0072111)4.30474741
37response to follicle-stimulating hormone (GO:0032354)4.30241239
38ATP synthesis coupled proton transport (GO:0015986)4.22116550
39energy coupled proton transport, down electrochemical gradient (GO:0015985)4.22116550
40macromolecular complex disassembly (GO:0032984)4.17388601
41myelination in peripheral nervous system (GO:0022011)4.13254307
42peripheral nervous system axon ensheathment (GO:0032292)4.13254307
43ribosomal large subunit biogenesis (GO:0042273)4.12584718
44morphogenesis of an endothelium (GO:0003159)4.11699449
45endothelial tube morphogenesis (GO:0061154)4.11699449
46dermatan sulfate metabolic process (GO:0030205)4.10755104
47protein targeting to membrane (GO:0006612)4.10458295
48mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.09951555
49Notch signaling involved in heart development (GO:0061314)4.03674983
50artery development (GO:0060840)4.01280506
51cranial suture morphogenesis (GO:0060363)4.00467257
52superoxide anion generation (GO:0042554)3.99518855
53endocardial cushion morphogenesis (GO:0003203)3.92495984
54establishment of protein localization to mitochondrial membrane (GO:0090151)3.88122084
55positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.88084003
56opsonization (GO:0008228)3.87519043
57heart valve morphogenesis (GO:0003179)3.87043223
58mesenchymal cell development (GO:0014031)3.74523735
59neural crest cell development (GO:0014032)3.74091620
60chondrocyte development (GO:0002063)3.73759339
61outflow tract septum morphogenesis (GO:0003148)3.73339502
62collagen fibril organization (GO:0030199)3.73338524
63translation (GO:0006412)3.65837101
64protein hydroxylation (GO:0018126)3.62343558
65positive regulation of endothelial cell differentiation (GO:0045603)3.61627545
66respiratory electron transport chain (GO:0022904)3.59165992
67chaperone-mediated protein transport (GO:0072321)3.56104144
68electron transport chain (GO:0022900)3.56026524
69middle ear morphogenesis (GO:0042474)3.54458290
70negative regulation of humoral immune response (GO:0002921)3.54160217
71adenine nucleotide transport (GO:0051503)3.51977416
72purine ribonucleotide transport (GO:0015868)3.50227218
73organ formation (GO:0048645)3.48008680
74peptidyl-proline hydroxylation (GO:0019511)3.45347933
75negative regulation of myoblast differentiation (GO:0045662)3.42749066
76endothelial cell chemotaxis (GO:0035767)3.41839006
77nuclear-transcribed mRNA catabolic process (GO:0000956)3.40164036
78pattern specification involved in kidney development (GO:0061004)3.37797769
79positive regulation of respiratory burst (GO:0060267)3.34361716
80endothelial cell morphogenesis (GO:0001886)3.32983111
81cardiac right ventricle morphogenesis (GO:0003215)3.32650371
82face morphogenesis (GO:0060325)3.32402231
83protein K11-linked deubiquitination (GO:0035871)3.30795647
84regulation of endothelial cell differentiation (GO:0045601)3.27672964
85chondroitin sulfate catabolic process (GO:0030207)3.27376766
86cardiac septum morphogenesis (GO:0060411)3.26152591
87protein complex biogenesis (GO:0070271)3.26016014
88water-soluble vitamin biosynthetic process (GO:0042364)3.25115533
89response to interferon-beta (GO:0035456)3.24841375
90regulation of relaxation of muscle (GO:1901077)3.23998674
91mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.23778489
92mitochondrial respiratory chain complex I assembly (GO:0032981)3.23778489
93NADH dehydrogenase complex assembly (GO:0010257)3.23778489
94blood vessel maturation (GO:0001955)3.22935096
95negative regulation of DNA biosynthetic process (GO:2000279)3.22517691
96mRNA catabolic process (GO:0006402)3.22233936
97mesenchyme morphogenesis (GO:0072132)3.21670604
98adhesion of symbiont to host cell (GO:0044650)3.19924708
99virion attachment to host cell (GO:0019062)3.19924708
100auditory receptor cell stereocilium organization (GO:0060088)3.19747075
101regulation of cell proliferation involved in kidney development (GO:1901722)3.19191867
102negative regulation of smooth muscle contraction (GO:0045986)3.17046092
103cardiac epithelial to mesenchymal transition (GO:0060317)3.16353968
104angiogenesis involved in wound healing (GO:0060055)3.15956945
105glomerular filtration (GO:0003094)3.14602849
106atrioventricular valve morphogenesis (GO:0003181)3.12480830
107nephron tubule development (GO:0072080)3.12359976
108limb bud formation (GO:0060174)3.09163896
109ribonucleoprotein complex biogenesis (GO:0022613)3.08868049
110trabecula formation (GO:0060343)3.08050678
111cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.06725246
112purine nucleotide transport (GO:0015865)3.06097672
113arginine catabolic process (GO:0006527)3.05058883
114regulation of macrophage cytokine production (GO:0010935)3.02649235
115negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.02489401
116cartilage development (GO:0051216)3.02260171
117RNA catabolic process (GO:0006401)3.00452549
118glomerular basement membrane development (GO:0032836)2.99635100
119chondrocyte differentiation (GO:0002062)2.97561162
120DNA deamination (GO:0045006)2.96887490
121negative regulation of homotypic cell-cell adhesion (GO:0034111)2.95807877
122establishment of protein localization to membrane (GO:0090150)2.95502755
123glomerulus development (GO:0032835)2.95010428
124morphogenesis of an epithelial sheet (GO:0002011)2.94297792
125negative regulation of blood vessel endothelial cell migration (GO:0043537)2.93614854
126cell adhesion mediated by integrin (GO:0033627)2.93518778
127negative regulation of wound healing (GO:0061045)2.93317742
128stem cell development (GO:0048864)2.92725894
129platelet dense granule organization (GO:0060155)2.91918921
130epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.91073049
131regulation of skeletal muscle contraction (GO:0014819)2.88977192
132heme transport (GO:0015886)2.88604859
133termination of RNA polymerase III transcription (GO:0006386)2.88568527
134transcription elongation from RNA polymerase III promoter (GO:0006385)2.88568527
135mitochondrial respiratory chain complex assembly (GO:0033108)2.88408770
136glycosaminoglycan biosynthetic process (GO:0006024)2.87449238
137nephron epithelium development (GO:0072009)2.86719069
138endothelial cell proliferation (GO:0001935)2.86469458
139regulation of glomerulus development (GO:0090192)2.85772745
140smooth muscle tissue development (GO:0048745)2.84924667
141positive regulation of cartilage development (GO:0061036)2.84639261
142cellular response to interferon-beta (GO:0035458)2.83970305
143detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.83772661
144aminoglycan biosynthetic process (GO:0006023)2.83233901
145vascular endothelial growth factor signaling pathway (GO:0038084)2.83155291
146positive regulation of odontogenesis (GO:0042482)2.82708147
147meiotic chromosome segregation (GO:0045132)2.82095931
148negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.81768826
149cellular component biogenesis (GO:0044085)2.79172442
150adhesion of symbiont to host (GO:0044406)2.78101487
151peripheral nervous system neuron development (GO:0048935)2.76299091
152negative regulation of platelet activation (GO:0010544)2.75875552
153regulation of metalloenzyme activity (GO:0048552)2.74860344
154regulation of cardiac muscle cell differentiation (GO:2000725)2.71312249
155DNA replication checkpoint (GO:0000076)2.71004870
156protein heterotrimerization (GO:0070208)2.70075708
157renal tubule development (GO:0061326)2.69942634
158regulation of respiratory burst (GO:0060263)2.69580666
159chondroitin sulfate metabolic process (GO:0030204)2.67879953
160regulation of apoptotic process involved in morphogenesis (GO:1902337)2.67497644
161heart trabecula formation (GO:0060347)2.64563604
162renal filtration (GO:0097205)2.63832869
163craniofacial suture morphogenesis (GO:0097094)2.63825314
164inner ear receptor cell differentiation (GO:0060113)2.63181659
165regulation of myoblast differentiation (GO:0045661)2.61688287
166negative regulation of endothelial cell proliferation (GO:0001937)2.61489117
167protein targeting (GO:0006605)2.61258936
168positive regulation of urine volume (GO:0035810)2.60628331
169negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.59398248
170extracellular matrix organization (GO:0030198)2.59256044
171extracellular structure organization (GO:0043062)2.58809811
172cell proliferation involved in metanephros development (GO:0072203)2.58293079
173regulation of mitochondrial translation (GO:0070129)2.57453914
174response to BMP (GO:0071772)2.56460072
175cellular response to BMP stimulus (GO:0071773)2.56460072
176negative regulation of endothelial cell migration (GO:0010596)2.54936295
177regulation of organ formation (GO:0003156)2.53089854
178cell differentiation involved in metanephros development (GO:0072202)2.50572262
179negative regulation of nitric-oxide synthase activity (GO:0051001)2.49748355
180vasculature development (GO:0001944)2.48161171
181endocardial cushion development (GO:0003197)2.46370125
182embryonic skeletal joint morphogenesis (GO:0060272)2.45368670
183endothelial cell differentiation (GO:0045446)2.45112196
184organ induction (GO:0001759)2.44287621
185cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.41779057
186establishment of protein localization to organelle (GO:0072594)2.41732468
187L-ascorbic acid metabolic process (GO:0019852)2.39777420
188cell migration involved in heart development (GO:0060973)2.39521638
189cardiovascular system development (GO:0072358)2.39212573

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.79275208
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.02248851
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.81078754
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.52824622
5AR_21572438_ChIP-Seq_LNCaP_Human3.51611704
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.16685033
7CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.81012178
8GATA1_22025678_ChIP-Seq_K562_Human2.67038890
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.60074090
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.54402148
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.49687917
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.44036184
13VDR_22108803_ChIP-Seq_LS180_Human2.37204080
14HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.24020549
15CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.21439098
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.16231238
17SMC3_22415368_ChIP-Seq_MEFs_Mouse2.13972462
18CJUN_26792858_Chip-Seq_BT549_Human2.10440923
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.09148430
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.07568180
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.04467270
22STAT6_21828071_ChIP-Seq_BEAS2B_Human2.04013845
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.03333831
24SRF_21415370_ChIP-Seq_HL-1_Mouse1.98738160
25EZH2_22144423_ChIP-Seq_EOC_Human1.97671299
26ELK3_25401928_ChIP-Seq_HUVEC_Human1.95275154
27CTCF_27219007_Chip-Seq_Bcells_Human1.95234759
28ZNF217_24962896_ChIP-Seq_MCF-7_Human1.94690628
29BP1_19119308_ChIP-ChIP_Hs578T_Human1.93680954
30SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.92173501
31CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.91541312
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.90670956
33PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.89948244
34VDR_21846776_ChIP-Seq_THP-1_Human1.89921593
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.88918272
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.88699259
37EZH2_18974828_ChIP-Seq_MESCs_Mouse1.84878949
38RNF2_18974828_ChIP-Seq_MESCs_Mouse1.84878949
39TP53_18474530_ChIP-ChIP_U2OS_Human1.84696502
40ETS1_20019798_ChIP-Seq_JURKAT_Human1.83459636
41SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.83228072
42RARG_19884340_ChIP-ChIP_MEFs_Mouse1.82045437
43ZNF263_19887448_ChIP-Seq_K562_Human1.77052092
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.75540965
45EST1_17652178_ChIP-ChIP_JURKAT_Human1.73218666
46MYC_19079543_ChIP-ChIP_MESCs_Mouse1.72751198
47GBX2_23144817_ChIP-Seq_PC3_Human1.69684453
48CTCF_18555785_ChIP-Seq_MESCs_Mouse1.68152231
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.67429748
50EZH2_27294783_Chip-Seq_NPCs_Mouse1.66501761
51ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.65171600
52TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.65021319
53SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.63792972
54MYC_18358816_ChIP-ChIP_MESCs_Mouse1.62054935
55EP300_21415370_ChIP-Seq_HL-1_Mouse1.59145444
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57978568
57HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.57761310
58* SA1_22415368_ChIP-Seq_MEFs_Mouse1.57413412
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.56521448
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.56136124
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.55683314
62RAD21_21589869_ChIP-Seq_MESCs_Mouse1.55236890
63NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.55200388
64EZH2_27304074_Chip-Seq_ESCs_Mouse1.54600684
65XRN2_22483619_ChIP-Seq_HELA_Human1.53748491
66JARID2_20064375_ChIP-Seq_MESCs_Mouse1.52707378
67* LXR_22292898_ChIP-Seq_THP-1_Human1.49641731
68EWS_26573619_Chip-Seq_HEK293_Human1.49558537
69SA1_27219007_Chip-Seq_ERYTHROID_Human1.48838290
70FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48353470
71EGR1_19374776_ChIP-ChIP_THP-1_Human1.46478885
72SALL4_18804426_ChIP-ChIP_XEN_Mouse1.43033419
73BCL6_27268052_Chip-Seq_Bcells_Human1.42865241
74ELF1_20517297_ChIP-Seq_JURKAT_Human1.42401059
75CTCF_26484167_Chip-Seq_Bcells_Mouse1.41746288
76NRF2_20460467_ChIP-Seq_MEFs_Mouse1.41492298
77NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.41492298
78WT1_19549856_ChIP-ChIP_CCG9911_Human1.40331990
79TP63_19390658_ChIP-ChIP_HaCaT_Human1.39604497
80* YY1_22570637_ChIP-Seq_MALME-3M_Human1.38282968
81JARID2_20075857_ChIP-Seq_MESCs_Mouse1.37478115
82VDR_24763502_ChIP-Seq_THP-1_Human1.36623857
83RNF2_27304074_Chip-Seq_ESCs_Mouse1.36300865
84TP53_20018659_ChIP-ChIP_R1E_Mouse1.36178069
85HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.36127570
86KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.35453147
87P53_22387025_ChIP-Seq_ESCs_Mouse1.35388733
88CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.34652286
89SA1_27219007_Chip-Seq_Bcells_Human1.34285047
90PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33675088
91STAT3_18555785_Chip-Seq_ESCs_Mouse1.33476136
92CTCF_20526341_ChIP-Seq_ESCs_Human1.33432090
93TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33176912
94P53_21459846_ChIP-Seq_SAOS-2_Human1.33033243
95ELK1_22589737_ChIP-Seq_MCF10A_Human1.31725337
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31613749
97SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31588683
98UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.31197527
99RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31085375
100SUZ12_18555785_Chip-Seq_ESCs_Mouse1.30127906
101IRF8_22096565_ChIP-ChIP_GC-B_Human1.28503675
102* GATA3_21878914_ChIP-Seq_MCF-7_Human1.28375920
103TTF2_22483619_ChIP-Seq_HELA_Human1.27822728
104NMYC_18555785_Chip-Seq_ESCs_Mouse1.27512671
105FLI1_27457419_Chip-Seq_LIVER_Mouse1.27246428
106CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.26856763
107PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26495442
108TP53_22127205_ChIP-Seq_IMR90_Human1.26273036
109EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26190427
110SMC1_22415368_ChIP-Seq_MEFs_Mouse1.25707190
111IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.25067578
112TET1_21451524_ChIP-Seq_MESCs_Mouse1.24281263
113EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.24084159
114SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.20356688
115NANOG_18555785_Chip-Seq_ESCs_Mouse1.20342126
116TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19026132
117SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.17661126
118SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.17579188
119SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.17579188
120POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17427353
121CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16082454
122ELK1_19687146_ChIP-ChIP_HELA_Human1.15698022
123CBX2_27304074_Chip-Seq_ESCs_Mouse1.15571846
124CRX_20693478_ChIP-Seq_RETINA_Mouse1.15445292
125GF1B_26923725_Chip-Seq_HPCs_Mouse1.15242524
126BCAT_22108803_ChIP-Seq_LS180_Human1.14501638
127KLF4_18555785_Chip-Seq_ESCs_Mouse1.14410091
128PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13755143
129E2F1_18555785_Chip-Seq_ESCs_Mouse1.13730493
130EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.13493663
131SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.13304337
132OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13045395
133PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12664733
134POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12598322
135* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.12154037
136PPAR_26484153_Chip-Seq_NCI-H1993_Human1.11849869
137FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11224760
138MTF2_20144788_ChIP-Seq_MESCs_Mouse1.10783240
139SOX2_18555785_Chip-Seq_ESCs_Mouse1.10720670
140BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10049824
141P63_26484246_Chip-Seq_KERATINOCYTES_Human1.09995231
142TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09459709
143CMYC_18555785_Chip-Seq_ESCs_Mouse1.08106066
144ISL1_27105846_Chip-Seq_CPCs_Mouse1.08104197
145BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07857757
146* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07775975
147FOXP1_21924763_ChIP-Seq_HESCs_Human1.07750806
148P300_18555785_Chip-Seq_ESCs_Mouse1.07741299
149PU1_27457419_Chip-Seq_LIVER_Mouse1.07696664
150ER_23166858_ChIP-Seq_MCF-7_Human1.07551300
151CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07517629
152SUZ12_27294783_Chip-Seq_ESCs_Mouse1.07228594
153EZH2_27294783_Chip-Seq_ESCs_Mouse1.06704804
154KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.06347042
155ERG_21242973_ChIP-ChIP_JURKAT_Human1.05564926
156P300_19829295_ChIP-Seq_ESCs_Human1.05496278
157GATA2_21666600_ChIP-Seq_HMVEC_Human1.04877014
158SOX11_22085726_ChIP-Seq_ESNs_Mouse1.04562878
159OCT4_18555785_Chip-Seq_ESCs_Mouse1.04449257
160STAT1_20625510_ChIP-Seq_HELA_Human1.02932354
161P68_20966046_ChIP-Seq_HELA_Human1.01306958
162STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.99781158
163CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99515324
164RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.99364554
165MAF_26560356_Chip-Seq_TH2_Human0.98927480
166* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.96812975
167RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96115179
168* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.95276952
169TAF2_19829295_ChIP-Seq_ESCs_Human0.94804159
170RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93790865
171NANOG_20526341_ChIP-Seq_ESCs_Human0.93562401
172MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.92457270
173SPI1_20517297_ChIP-Seq_HL60_Human0.91670865
174KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91107458
175ERA_21632823_ChIP-Seq_H3396_Human0.90122341
176BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89659798
177FOXH1_21741376_ChIP-Seq_ESCs_Human0.89429435
178P300_27268052_Chip-Seq_Bcells_Human0.89060447
179* HNFA_21074721_ChIP-Seq_CACO-2_Human0.88921211
180PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.87841690
181GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87239092
182E2F1_20622854_ChIP-Seq_HELA_Human0.87057105

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology6.33390864
2MP0008438_abnormal_cutaneous_collagen4.73610155
3MP0005275_abnormal_skin_tensile3.37127588
4MP0003941_abnormal_skin_development3.34248176
5MP0004272_abnormal_basement_membrane3.22705515
6MP0000751_myopathy2.68972430
7MP0001188_hyperpigmentation2.61661350
8MP0002282_abnormal_trachea_morphology2.58608946
9MP0005508_abnormal_skeleton_morphology2.53754733
10MP0000516_abnormal_urinary_system2.51345860
11MP0005367_renal/urinary_system_phenotyp2.51345860
12MP0002089_abnormal_postnatal_growth/wei2.44951442
13MP0004484_altered_response_of2.42486881
14MP0003122_maternal_imprinting2.33471905
15MP0005085_abnormal_gallbladder_physiolo2.30822086
16MP0005084_abnormal_gallbladder_morpholo2.26139151
17MP0000163_abnormal_cartilage_morphology2.22125157
18MP0010030_abnormal_orbit_morphology2.21338655
19MP0000762_abnormal_tongue_morphology2.05553674
20MP0003806_abnormal_nucleotide_metabolis2.05441961
21MP0003705_abnormal_hypodermis_morpholog2.02441052
22MP0010368_abnormal_lymphatic_system1.97752569
23MP0002108_abnormal_muscle_morphology1.94729990
24MP0002139_abnormal_hepatobiliary_system1.82254202
25MP0002933_joint_inflammation1.81088871
26MP0006292_abnormal_olfactory_placode1.77841378
27MP0002295_abnormal_pulmonary_circulatio1.76926447
28MP0000613_abnormal_salivary_gland1.72243867
29MP0003828_pulmonary_edema1.71871875
30MP0009384_cardiac_valve_regurgitation1.71016910
31MP0000049_abnormal_middle_ear1.69083933
32MP0001879_abnormal_lymphatic_vessel1.68451562
33MP0002138_abnormal_hepatobiliary_system1.65303941
34MP0003011_delayed_dark_adaptation1.64164564
35MP0002249_abnormal_larynx_morphology1.62990246
36MP0009250_abnormal_appendicular_skeleto1.62386853
37MP0004134_abnormal_chest_morphology1.60937775
38MP0002928_abnormal_bile_duct1.57485517
39MP0003385_abnormal_body_wall1.56273669
40MP0005248_abnormal_Harderian_gland1.55379736
41MP0009053_abnormal_anal_canal1.46727678
42MP0005083_abnormal_biliary_tract1.42846419
43MP0002115_abnormal_skeleton_extremities1.42502463
44MP0001661_extended_life_span1.42361579
45MP0003787_abnormal_imprinting1.39939714
46MP0000767_abnormal_smooth_muscle1.39122748
47MP0005023_abnormal_wound_healing1.34817396
48MP0003943_abnormal_hepatobiliary_system1.34469089
49MP0000749_muscle_degeneration1.34146395
50MP0009697_abnormal_copulation1.33141537
51MP0003566_abnormal_cell_adhesion1.31457484
52MP0003283_abnormal_digestive_organ1.28980268
53MP0000566_synostosis1.28378157
54MP0005390_skeleton_phenotype1.26855003
55MP0003186_abnormal_redox_activity1.23818513
56MP0005167_abnormal_blood-brain_barrier1.23481353
57MP0002233_abnormal_nose_morphology1.22605185
58MP0004084_abnormal_cardiac_muscle1.20502742
59MP0000343_altered_response_to1.20108417
60MP0003252_abnormal_bile_duct1.20098535
61MP0002163_abnormal_gland_morphology1.19236707
62MP0003950_abnormal_plasma_membrane1.18992586
63MP0003121_genomic_imprinting1.18348197
64MP0003136_yellow_coat_color1.17726983
65MP0002113_abnormal_skeleton_development1.17051530
66MP0003942_abnormal_urinary_system1.16837371
67MP0003115_abnormal_respiratory_system1.16618318
68MP0003123_paternal_imprinting1.15629068
69MP0005451_abnormal_body_composition1.14676998
70MP0004043_abnormal_pH_regulation1.14313780
71MP0002060_abnormal_skin_morphology1.13763606
72MP0001542_abnormal_bone_strength1.12074599
73MP0002127_abnormal_cardiovascular_syste1.11666223
74MP0005646_abnormal_pituitary_gland1.11169852
75MP0000465_gastrointestinal_hemorrhage1.09665369
76MP0003755_abnormal_palate_morphology1.08934408
77MP0006054_spinal_hemorrhage1.08029808
78MP0001177_atelectasis1.06276517
79MP0002116_abnormal_craniofacial_bone1.05088711
80MP0002735_abnormal_chemical_nociception1.05045262
81MP0002876_abnormal_thyroid_physiology1.03884133
82MP0002938_white_spotting1.02576741
83MP0005620_abnormal_muscle_contractility1.01908341
84MP0002877_abnormal_melanocyte_morpholog1.00616590
85MP0004885_abnormal_endolymph1.00269653
86MP0002109_abnormal_limb_morphology0.99944999
87MP0002972_abnormal_cardiac_muscle0.99209541
88MP0001243_abnormal_dermal_layer0.98852552
89MP0008775_abnormal_heart_ventricle0.96024058
90MP0003646_muscle_fatigue0.95372689
91MP0002932_abnormal_joint_morphology0.95070761
92MP0005410_abnormal_fertilization0.94334189
93MP0005330_cardiomyopathy0.93502104
94MP0001958_emphysema0.93490518
95MP0001485_abnormal_pinna_reflex0.93295257
96MP0005501_abnormal_skin_physiology0.92357898
97MP0003315_abnormal_perineum_morphology0.92085263
98MP0005595_abnormal_vascular_smooth0.91583345
99MP0003279_aneurysm0.91472663
100MP0000534_abnormal_ureter_morphology0.91276751
101MP0003119_abnormal_digestive_system0.90662326
102MP0002128_abnormal_blood_circulation0.90500081
103MP0005197_abnormal_uvea_morphology0.90187556
104MP0008875_abnormal_xenobiotic_pharmacok0.89559755
105MP0004133_heterotaxia0.87724799
106MP0003786_premature_aging0.87544380
107MP0000013_abnormal_adipose_tissue0.87543840
108MP0003935_abnormal_craniofacial_develop0.86613280
109MP0000678_abnormal_parathyroid_gland0.86306549
110MP0002396_abnormal_hematopoietic_system0.85574414
111MP0000462_abnormal_digestive_system0.84653502
112MP0002132_abnormal_respiratory_system0.84094663
113MP0004019_abnormal_vitamin_homeostasis0.84053144
114MP0005670_abnormal_white_adipose0.83406018
115MP0000432_abnormal_head_morphology0.82685607
116MP0005171_absent_coat_pigmentation0.79791839
117MP0001544_abnormal_cardiovascular_syste0.78963559
118MP0005385_cardiovascular_system_phenoty0.78963559
119MP0000681_abnormal_thyroid_gland0.78954653
120MP0004036_abnormal_muscle_relaxation0.78042523
121MP0005165_increased_susceptibility_to0.76667777
122MP0006138_congestive_heart_failure0.75058752
123MP0005369_muscle_phenotype0.75052325
124MP0000537_abnormal_urethra_morphology0.74391273
125MP0008007_abnormal_cellular_replicative0.74129594
126MP0001764_abnormal_homeostasis0.74095921
127MP0002277_abnormal_respiratory_mucosa0.73775250
128MP0001293_anophthalmia0.73209186
129MP0000230_abnormal_systemic_arterial0.72456353
130MP0004142_abnormal_muscle_tone0.71644275
131MP0003567_abnormal_fetal_cardiomyocyte0.71158819
132MP0001614_abnormal_blood_vessel0.70037636
133MP0002111_abnormal_tail_morphology0.69867204
134MP0002160_abnormal_reproductive_system0.69734884
135MP0001986_abnormal_taste_sensitivity0.68979957
136MP0000631_abnormal_neuroendocrine_gland0.68113255
137MP0009379_abnormal_foot_pigmentation0.67671301
138MP0002133_abnormal_respiratory_system0.67441859
139MP0000249_abnormal_blood_vessel0.65066405
140MP0005257_abnormal_intraocular_pressure0.64979129
141MP0001849_ear_inflammation0.64657380
142MP0006036_abnormal_mitochondrial_physio0.63324630
143MP0002896_abnormal_bone_mineralization0.61346841
144MP0003938_abnormal_ear_development0.61015319
145MP0005174_abnormal_tail_pigmentation0.60313482
146MP0003638_abnormal_response/metabolism_0.60161625
147MP0005381_digestive/alimentary_phenotyp0.59258806

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)6.26394372
2Irregular epiphyses (HP:0010582)6.04427654
3Absent epiphyses (HP:0010577)5.93178834
4Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)5.93178834
5Reticulocytopenia (HP:0001896)5.75607720
6Wrist flexion contracture (HP:0001239)5.71059615
7Vitreoretinal degeneration (HP:0000655)5.63549016
8Hypoplasia of the capital femoral epiphysis (HP:0003090)5.28059867
9Metaphyseal dysplasia (HP:0100255)4.76164787
10Small epiphyses (HP:0010585)4.61469161
11Mitral stenosis (HP:0001718)4.60715112
12Abnormal tarsal ossification (HP:0008369)4.55943404
13Abnormality involving the epiphyses of the lower limbs (HP:0006500)4.38853147
14Abnormality of femoral epiphyses (HP:0006499)4.38853147
15Abnormality of cells of the erythroid lineage (HP:0012130)4.31274763
16Metaphyseal cupping (HP:0003021)4.29992797
17Abnormality of the epiphysis of the femoral head (HP:0010574)4.21306769
18J-shaped sella turcica (HP:0002680)4.15293182
19Cervical subluxation (HP:0003308)4.08883993
20Flat capital femoral epiphysis (HP:0003370)4.03419773
21Abnormality of the femoral head (HP:0003368)3.89997244
22Round ear (HP:0100830)3.86164202
23Abnormal number of erythroid precursors (HP:0012131)3.81660037
24Macrocytic anemia (HP:0001972)3.81557659
25Acute necrotizing encephalopathy (HP:0006965)3.78668227
26Congenital, generalized hypertrichosis (HP:0004540)3.77456801
27Mild short stature (HP:0003502)3.66312404
28Cupped ribs (HP:0000887)3.61353537
29Genu varum (HP:0002970)3.59590938
30Distal lower limb muscle weakness (HP:0009053)3.58019819
31Aplasia/Hypoplasia of the sacrum (HP:0008517)3.52534677
32Hypoplastic ischia (HP:0003175)3.41399589
33Flat acetabular roof (HP:0003180)3.29726322
34Abnormal foot bone ossification (HP:0010675)3.29683032
35Septo-optic dysplasia (HP:0100842)3.27261926
36Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.24957267
37Mitochondrial inheritance (HP:0001427)3.22264656
38Abnormal mitochondria in muscle tissue (HP:0008316)3.19616547
39Premature rupture of membranes (HP:0001788)3.17332885
40Pallor (HP:0000980)3.14304330
41Delayed epiphyseal ossification (HP:0002663)3.14227090
42Acute encephalopathy (HP:0006846)3.05788995
43Progressive macrocephaly (HP:0004481)3.01886731
44Maternal diabetes (HP:0009800)3.01763480
45Thickened helices (HP:0000391)3.00884065
46Abnormality of the ischium (HP:0003174)2.97625627
47Abnormal pancreas size (HP:0012094)2.95224598
48Hip contracture (HP:0003273)2.91184630
49Abnormality of carpal bone ossification (HP:0006257)2.90568572
50Limited hip movement (HP:0008800)2.73525913
51Hepatocellular necrosis (HP:0001404)2.71411360
52Irregular vertebral endplates (HP:0003301)2.71244192
53Stenosis of the external auditory canal (HP:0000402)2.71040503
54Mesomelia (HP:0003027)2.68205245
55Abnormal vertebral ossification (HP:0100569)2.65193272
56Nonprogressive disorder (HP:0003680)2.64786464
57Clumsiness (HP:0002312)2.62807159
58Platyspondyly (HP:0000926)2.62782026
59Spontaneous hematomas (HP:0007420)2.61116457
60Anterior segment dysgenesis (HP:0007700)2.59684808
61Arthropathy (HP:0003040)2.58753433
62Coxa vara (HP:0002812)2.57513034
63Soft skin (HP:0000977)2.57003966
64Abnormality of the vertebral endplates (HP:0005106)2.56671465
65Neonatal short-limb short stature (HP:0008921)2.55552147
66Patent foramen ovale (HP:0001655)2.53813363
67Short femoral neck (HP:0100864)2.53120419
68Increased CSF lactate (HP:0002490)2.50279644
69Joint stiffness (HP:0001387)2.50126438
70Short middle phalanx of finger (HP:0005819)2.46443802
71Broad metatarsal (HP:0001783)2.45114915
72Coxa valga (HP:0002673)2.42582678
73Thrombocytosis (HP:0001894)2.41163012
74Aortic valve stenosis (HP:0001650)2.40181475
75Nonimmune hydrops fetalis (HP:0001790)2.38771125
76Osteoarthritis (HP:0002758)2.35828101
77Aortic dissection (HP:0002647)2.35390950
78Abnormality of incisor morphology (HP:0011063)2.33893940
79Diastasis recti (HP:0001540)2.33020624
80Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.32202646
81Carpal bone hypoplasia (HP:0001498)2.31994550
82Polycythemia (HP:0001901)2.24639835
83Tracheal stenosis (HP:0002777)2.23414236
84Hematochezia (HP:0002573)2.20624732
85Pulmonary artery stenosis (HP:0004415)2.20129308
86Flattened epiphyses (HP:0003071)2.18619784
87Spinal rigidity (HP:0003306)2.18600913
88Waddling gait (HP:0002515)2.17156898
89Metaphyseal irregularity (HP:0003025)2.16939549
90Cerebral edema (HP:0002181)2.15947533
91Paralysis (HP:0003470)2.13737923
92Increased corneal curvature (HP:0100692)2.11913775
93Keratoconus (HP:0000563)2.11913775
94Protrusio acetabuli (HP:0003179)2.11448042
95Renal Fanconi syndrome (HP:0001994)2.09349279
96Abnormality of placental membranes (HP:0011409)2.09181771
97Amniotic constriction ring (HP:0009775)2.09181771
98Bulbous nose (HP:0000414)2.09167218
99Persistence of primary teeth (HP:0006335)2.07193433
100Micromelia (HP:0002983)2.05492476
101Hypoplastic pelvis (HP:0008839)2.05274805
102Hepatic necrosis (HP:0002605)2.05272142
103Spinal cord compression (HP:0002176)2.05181751
104Hypoplastic left heart (HP:0004383)2.05172565
105Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.04701190
106Vertebral hypoplasia (HP:0008417)2.04701190
107Hypoplastic heart (HP:0001961)2.03902802
108Flared iliac wings (HP:0002869)2.01945092
109Megalencephaly (HP:0001355)2.01284732
110Hepatoblastoma (HP:0002884)2.00907103
111Aplasia/hypoplasia of the femur (HP:0005613)2.00031124
112Vertebral arch anomaly (HP:0008438)1.99740711
113Severe visual impairment (HP:0001141)1.98525275
114Chorioretinal atrophy (HP:0000533)1.96741060
1153-Methylglutaconic aciduria (HP:0003535)1.96260048
116Ankle contracture (HP:0006466)1.96249304
117Abnormal ossification of hand bones (HP:0005921)1.96076579
118Aortic regurgitation (HP:0001659)1.95926658
119Exertional dyspnea (HP:0002875)1.95653912
120Prolonged neonatal jaundice (HP:0006579)1.94747995
121Conjunctival telangiectasia (HP:0000524)1.93741034
122Stillbirth (HP:0003826)1.92775170
123Adactyly (HP:0009776)1.92384113
124Spinal cord lesions (HP:0100561)1.91511261
125Syringomyelia (HP:0003396)1.91511261
126Fibular hypoplasia (HP:0003038)1.91032095
127Abnormal hand bone ossification (HP:0010660)1.89612334
128Absent thumb (HP:0009777)1.88248540
129Delayed CNS myelination (HP:0002188)1.87760421
130Slender long bone (HP:0003100)1.87590527
131Barrel-shaped chest (HP:0001552)1.86578662
132Abnormality of the pubic bones (HP:0003172)1.85986394
133Visceral angiomatosis (HP:0100761)1.84679775
134Disproportionate short-trunk short stature (HP:0003521)1.84154475
135Abnormality of the lumbar spine (HP:0100712)1.82841750
136Abnormality of the phalanges of the 2nd finger (HP:0009541)1.82736062
137Deformed sella turcica (HP:0002681)1.82062548
138Abnormality of the frontal sinuses (HP:0002687)1.80791253
139Absent septum pellucidum (HP:0001331)1.80368217
140Abnormality of the acetabulum (HP:0003170)1.77842757
141Ovoid vertebral bodies (HP:0003300)1.76517276
142Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.76000185
143Adrenal hypoplasia (HP:0000835)1.75438870
144Venous insufficiency (HP:0005293)1.75084666
145Abnormality of the nasal mucosa (HP:0000433)1.74634583
146Lymphangioma (HP:0100764)1.74451574
147Hemangiomatosis (HP:0007461)1.74330372
148Increased hepatocellular lipid droplets (HP:0006565)1.74137121
149Fragile skin (HP:0001030)1.73334487
150Aortic aneurysm (HP:0004942)1.73097759
151Porencephaly (HP:0002132)1.72385541
152Rib fusion (HP:0000902)1.71845088
153Sensory axonal neuropathy (HP:0003390)1.71584994
154Respiratory failure (HP:0002878)1.71213416
155Aplasia/Hypoplasia involving the musculature (HP:0001460)1.70803450
156Abnormality of renal resorption (HP:0011038)1.69576657
157Abnormality of the right ventricle (HP:0001707)1.69244800
158Corneal dystrophy (HP:0001131)1.68782171
159Abnormality of DNA repair (HP:0003254)1.68323489
160Bell-shaped thorax (HP:0001591)1.67932009
161Abnormality of the pulmonary veins (HP:0011718)1.67485941
162High pitched voice (HP:0001620)1.67483640
163Round face (HP:0000311)1.67420268
164Abnormality of the middle phalanges of the hand (HP:0009833)1.67222738
165Abnormality of the dental root (HP:0006486)1.66817337
166Taurodontia (HP:0000679)1.66817337
167Abnormality of permanent molar morphology (HP:0011071)1.66817337
168Absent frontal sinuses (HP:0002688)1.66790696
169Broad palm (HP:0001169)1.66591373
170Blue sclerae (HP:0000592)1.66454614
171Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.65152014
172Woolly hair (HP:0002224)1.65101493
173Type I transferrin isoform profile (HP:0003642)1.64732669
174Bilateral microphthalmos (HP:0007633)1.64430807
175Lipid accumulation in hepatocytes (HP:0006561)1.64053308
176Abnormality of reticulocytes (HP:0004312)1.61401664
177Abnormality of the renal collecting system (HP:0004742)1.60647939
178Mesangial abnormality (HP:0001966)1.59572460
179Abnormality of the parietal bone (HP:0002696)1.58101275
180Ileus (HP:0002595)1.57941269

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK38L5.86748448
2TLK15.66943343
3STK245.09663840
4CASK4.99035068
5INSRR3.51902239
6ZAK3.45974570
7EPHB23.43136239
8ERBB33.21787216
9STK162.88338107
10KIT2.84818657
11FLT32.74726144
12NEK62.58707168
13OBSCN2.50283355
14EPHA21.90146493
15TRPM71.88782496
16MAP3K141.88655800
17PRPF4B1.85687110
18AKT31.83572929
19VRK21.81938897
20DDR21.79424287
21SCYL21.69096297
22BMPR1B1.62175507
23BUB11.59178717
24STK31.54579013
25FRK1.52507988
26EIF2AK21.51445577
27ABL21.49102835
28KDR1.45648263
29MST41.42375897
30NME11.40413214
31TGFBR11.40391034
32MAP3K121.38131144
33MAP3K31.35923775
34CDC71.35865812
35MYLK1.35831765
36PLK41.32395921
37BMPR21.31672316
38LATS21.29823838
39NUAK11.25661556
40CDK81.23927652
41TAOK31.21212678
42MAP3K61.20207856
43BCKDK1.18414187
44RPS6KA41.18383619
45PIK3CA1.17573022
46CLK11.16931307
47MAP4K21.16169494
48DMPK1.16068278
49TGFBR21.14123885
50PIK3CG1.06401284
51NEK21.05569204
52PRKG21.05284982
53MAPK151.04695206
54MUSK1.04447300
55SGK21.03211770
56MKNK11.02427098
57ADRBK10.99563629
58FES0.99119541
59TEC0.98707874
60MAP4K10.91049859
61LRRK20.90389125
62PIM10.89145797
63PLK20.88857422
64MKNK20.88080778
65TAOK20.85833428
66ILK0.83566488
67MAPK70.81977147
68FER0.80832112
69TSSK60.80307720
70YES10.79819832
71PINK10.77374799
72MST1R0.75019950
73MAP3K50.73880468
74MAP2K70.72267557
75NME20.71470395
76NLK0.68605024
77DAPK20.68381497
78CDC42BPA0.67549714
79CHEK20.65748832
80TNK20.64016947
81MAP2K30.63915770
82CDK190.62913096
83BCR0.62667781
84TIE10.62488780
85SGK4940.61974696
86SGK2230.61974696
87ROCK10.61806832
88NTRK10.60717158
89DAPK30.60442152
90SGK30.59066795
91TXK0.57437253
92DYRK20.56243966
93GRK60.55021819
94ADRBK20.54736769
95MATK0.54666414
96RPS6KA60.54496011
97GRK10.53957096
98PIM20.53483306
99IKBKE0.52824196
100PRKD10.50132687
101VRK10.49296283
102PTK20.49100446
103LIMK10.49052680
104RIPK10.48421381
105RPS6KC10.47229041
106RPS6KL10.47229041
107MAP3K110.47038017
108LMTK20.46943356
109PAK30.46853307
110PHKG20.46555401
111PHKG10.46555401
112MET0.46416077
113ITK0.45719402
114RPS6KB20.44910823
115JAK30.44478734
116NTRK30.43991295
117PAK20.43791386
118MAP3K70.43546524
119PRKD20.41719554
120IKBKB0.40671387
121PTK2B0.40490852
122GRK50.40400193
123CSNK2A10.40179507
124PRKCE0.40034496
125STK390.38772005
126MAPK120.38245282
127TBK10.38235942
128EPHA30.38215540
129AURKB0.38194886
130PAK40.37836227
131MARK30.37236181
132ZAP700.37206422
133PKN10.37180786
134PNCK0.36886766
135PDGFRA0.35698280
136PRKCH0.35607956
137CSF1R0.35270392
138HIPK20.35008375
139OXSR10.34986865
140PRKACA0.33974641
141PLK30.33871200
142PDK20.33819213
143TNIK0.33752006
144CCNB10.33510512
145EIF2AK30.33207788
146MARK20.32973829
147CDK30.32544456
148WNK10.32262483
149BMX0.32101609
150GSK3A0.30793089
151BTK0.30647436
152PRKCQ0.29507862
153MAPK30.28945319
154CSNK1A1L0.28319575
155CHUK0.27058455
156NEK90.26178550
157TTK0.23108526
158CAMK10.22166237
159SIK30.21926588
160CAMK2D0.20866252
161STK40.20183960
162IGF1R0.19921628
163EPHA40.19493515
164AKT10.19319078

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.47242700
2Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005344.61789996
3ECM-receptor interaction_Homo sapiens_hsa045124.37825982
4Oxidative phosphorylation_Homo sapiens_hsa001904.07742480
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005324.06109270
6Parkinsons disease_Homo sapiens_hsa050123.48515336
7Steroid biosynthesis_Homo sapiens_hsa001002.72703476
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.54720971
9Huntingtons disease_Homo sapiens_hsa050162.53949853
10Homologous recombination_Homo sapiens_hsa034402.49441258
11RNA polymerase_Homo sapiens_hsa030202.45891480
12Alzheimers disease_Homo sapiens_hsa050102.40791428
13Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.40088058
14Dilated cardiomyopathy_Homo sapiens_hsa054142.35992042
15Focal adhesion_Homo sapiens_hsa045102.32737390
16Protein digestion and absorption_Homo sapiens_hsa049742.30712954
17TGF-beta signaling pathway_Homo sapiens_hsa043502.27335609
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.01768023
19Protein export_Homo sapiens_hsa030601.92905074
20Sulfur relay system_Homo sapiens_hsa041221.90580188
21Bladder cancer_Homo sapiens_hsa052191.83015190
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.74045175
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.73429624
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.62373523
25Proteoglycans in cancer_Homo sapiens_hsa052051.60550065
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.57474322
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.56468741
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.55362145
29Linoleic acid metabolism_Homo sapiens_hsa005911.47581624
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.44687626
31PI3K-Akt signaling pathway_Homo sapiens_hsa041511.43077067
32Malaria_Homo sapiens_hsa051441.41564731
33Proteasome_Homo sapiens_hsa030501.38135601
34Thyroid cancer_Homo sapiens_hsa052161.35803009
35Small cell lung cancer_Homo sapiens_hsa052221.34459173
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34347981
37Nucleotide excision repair_Homo sapiens_hsa034201.33813158
38Viral myocarditis_Homo sapiens_hsa054161.33804325
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.29955711
40Glutathione metabolism_Homo sapiens_hsa004801.26345259
41Sphingolipid metabolism_Homo sapiens_hsa006001.25027589
42Arginine and proline metabolism_Homo sapiens_hsa003301.24939436
43DNA replication_Homo sapiens_hsa030301.24611758
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23359725
45Axon guidance_Homo sapiens_hsa043601.21805011
46ABC transporters_Homo sapiens_hsa020101.21275419
47Basal transcription factors_Homo sapiens_hsa030221.20305068
48Hippo signaling pathway_Homo sapiens_hsa043901.19649456
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17790165
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.16271468
51Asthma_Homo sapiens_hsa053101.16047902
52Basal cell carcinoma_Homo sapiens_hsa052171.14977435
53Amoebiasis_Homo sapiens_hsa051461.14258765
54Other glycan degradation_Homo sapiens_hsa005111.13783852
55Prion diseases_Homo sapiens_hsa050201.13479592
56ErbB signaling pathway_Homo sapiens_hsa040121.08290622
57Base excision repair_Homo sapiens_hsa034101.07703722
58Complement and coagulation cascades_Homo sapiens_hsa046101.07592599
59Chemical carcinogenesis_Homo sapiens_hsa052041.04621554
60Pyrimidine metabolism_Homo sapiens_hsa002401.04197560
61Pathways in cancer_Homo sapiens_hsa052001.03561324
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01685282
63Folate biosynthesis_Homo sapiens_hsa007901.01000502
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.00891369
65Purine metabolism_Homo sapiens_hsa002300.98103015
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95468071
67HTLV-I infection_Homo sapiens_hsa051660.95295164
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.95294442
69Vitamin digestion and absorption_Homo sapiens_hsa049770.94622012
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93922870
71Prostate cancer_Homo sapiens_hsa052150.93021510
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89783574
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.89430481
74Chronic myeloid leukemia_Homo sapiens_hsa052200.89042477
75Melanogenesis_Homo sapiens_hsa049160.87870485
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83948941
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.82485991
78Olfactory transduction_Homo sapiens_hsa047400.82122833
79Wnt signaling pathway_Homo sapiens_hsa043100.80499968
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.80356399
81Adherens junction_Homo sapiens_hsa045200.80048004
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.78034833
83Acute myeloid leukemia_Homo sapiens_hsa052210.76794972
84Fat digestion and absorption_Homo sapiens_hsa049750.75890774
85GnRH signaling pathway_Homo sapiens_hsa049120.75539987
86Endometrial cancer_Homo sapiens_hsa052130.74468309
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73772611
88Glycerolipid metabolism_Homo sapiens_hsa005610.72908285
89One carbon pool by folate_Homo sapiens_hsa006700.72119427
90Sulfur metabolism_Homo sapiens_hsa009200.71014266
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70441895
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69977860
93TNF signaling pathway_Homo sapiens_hsa046680.69767316
94Ovarian steroidogenesis_Homo sapiens_hsa049130.68931651
95Galactose metabolism_Homo sapiens_hsa000520.67645668
96Hematopoietic cell lineage_Homo sapiens_hsa046400.66348289
97Notch signaling pathway_Homo sapiens_hsa043300.66069694
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65122395
99Metabolic pathways_Homo sapiens_hsa011000.64996092
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.64812660
101Melanoma_Homo sapiens_hsa052180.64078422
102Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64031548
103Tight junction_Homo sapiens_hsa045300.63624200
104Hedgehog signaling pathway_Homo sapiens_hsa043400.63258238
105Arachidonic acid metabolism_Homo sapiens_hsa005900.63037625
106Dorso-ventral axis formation_Homo sapiens_hsa043200.61803028
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61554536
108MAPK signaling pathway_Homo sapiens_hsa040100.61020268
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60431468
110Starch and sucrose metabolism_Homo sapiens_hsa005000.60326245
111Retinol metabolism_Homo sapiens_hsa008300.59168428
112Nitrogen metabolism_Homo sapiens_hsa009100.58657218
113Maturity onset diabetes of the young_Homo sapiens_hsa049500.53085875
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.52664204
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.52518055
116Histidine metabolism_Homo sapiens_hsa003400.52176096
117Selenocompound metabolism_Homo sapiens_hsa004500.51644116
118RNA degradation_Homo sapiens_hsa030180.51467202
119Ras signaling pathway_Homo sapiens_hsa040140.51290195
120Ether lipid metabolism_Homo sapiens_hsa005650.50714927
121Toxoplasmosis_Homo sapiens_hsa051450.50422766
122Glioma_Homo sapiens_hsa052140.50277554
123Caffeine metabolism_Homo sapiens_hsa002320.49843750
124Pancreatic cancer_Homo sapiens_hsa052120.49313290
125Collecting duct acid secretion_Homo sapiens_hsa049660.49072276
126Apoptosis_Homo sapiens_hsa042100.47749837
127Cocaine addiction_Homo sapiens_hsa050300.47424765
128Phagosome_Homo sapiens_hsa041450.46533623
129Rap1 signaling pathway_Homo sapiens_hsa040150.46461057
130Tryptophan metabolism_Homo sapiens_hsa003800.45917567
131Gap junction_Homo sapiens_hsa045400.44558437
132FoxO signaling pathway_Homo sapiens_hsa040680.42917174
133MicroRNAs in cancer_Homo sapiens_hsa052060.42383659
134Fanconi anemia pathway_Homo sapiens_hsa034600.41924115
135Renin-angiotensin system_Homo sapiens_hsa046140.41845822
136Hepatitis B_Homo sapiens_hsa051610.41126948
137p53 signaling pathway_Homo sapiens_hsa041150.40753864
138Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40113083
139Estrogen signaling pathway_Homo sapiens_hsa049150.38579520
140Shigellosis_Homo sapiens_hsa051310.38535136
141Fatty acid degradation_Homo sapiens_hsa000710.38282295
142Cardiac muscle contraction_Homo sapiens_hsa042600.38192886
143Drug metabolism - other enzymes_Homo sapiens_hsa009830.37622897
144Phototransduction_Homo sapiens_hsa047440.36335484
145Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36138186
146Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35589123
147Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33939823
148Cholinergic synapse_Homo sapiens_hsa047250.33350454
149RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.33254223
150Amphetamine addiction_Homo sapiens_hsa050310.33180346
151Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33149490
152Platelet activation_Homo sapiens_hsa046110.32951523
153Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32558375
154cAMP signaling pathway_Homo sapiens_hsa040240.32458460
155Mismatch repair_Homo sapiens_hsa034300.32042991
156Calcium signaling pathway_Homo sapiens_hsa040200.30919377
157Salmonella infection_Homo sapiens_hsa051320.30841071
158Tyrosine metabolism_Homo sapiens_hsa003500.30406085
159Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.29510976
160Rheumatoid arthritis_Homo sapiens_hsa053230.28238099
161Spliceosome_Homo sapiens_hsa030400.27555889
162Glycerophospholipid metabolism_Homo sapiens_hsa005640.26270348
163African trypanosomiasis_Homo sapiens_hsa051430.24260819
164Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.22920961

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