LDLRAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)6.86126182
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.86126182
3negative T cell selection (GO:0043383)5.20203535
4negative thymic T cell selection (GO:0045060)5.08423445
5regulation of B cell receptor signaling pathway (GO:0050855)4.57857863
6thymic T cell selection (GO:0045061)4.23429606
7response to interleukin-15 (GO:0070672)4.19119953
8T cell selection (GO:0045058)4.16976186
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.15638689
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.15638689
11positive thymic T cell selection (GO:0045059)4.14126731
12positive T cell selection (GO:0043368)4.02983503
13regulation of regulatory T cell differentiation (GO:0045589)4.01889305
14positive regulation of granulocyte differentiation (GO:0030854)3.95661846
15negative regulation of lymphocyte mediated immunity (GO:0002707)3.93808118
16regulation of T cell tolerance induction (GO:0002664)3.89654674
17detection of bacterium (GO:0016045)3.89034497
18detection of other organism (GO:0098543)3.80861516
19positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.79140742
20tolerance induction (GO:0002507)3.77369790
21T cell migration (GO:0072678)3.76847822
22negative regulation of T cell mediated immunity (GO:0002710)3.73541169
23cellular response to interleukin-15 (GO:0071350)3.72633192
24negative regulation of leukocyte mediated immunity (GO:0002704)3.64970682
25signal complex assembly (GO:0007172)3.64922501
26regulation of alpha-beta T cell proliferation (GO:0046640)3.62292489
27neutrophil activation (GO:0042119)3.58806343
28regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.53403182
29regulation of natural killer cell mediated immunity (GO:0002715)3.53403182
30regulation of tolerance induction (GO:0002643)3.52690161
31negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.47996888
32negative regulation of glycoprotein biosynthetic process (GO:0010561)3.44233567
33fatty acid elongation (GO:0030497)3.42216588
34antigen processing and presentation of endogenous antigen (GO:0019883)3.41543712
35regulation of T cell mediated cytotoxicity (GO:0001914)3.40557409
36activated T cell proliferation (GO:0050798)3.39864819
37B cell receptor signaling pathway (GO:0050853)3.32749325
38regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.31098603
39dendritic cell chemotaxis (GO:0002407)3.30697993
40positive regulation of T cell mediated cytotoxicity (GO:0001916)3.25061145
41cellular extravasation (GO:0045123)3.22968324
42positive regulation of tolerance induction (GO:0002645)3.22886524
43amyloid precursor protein catabolic process (GO:0042987)3.21375278
44positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.19329843
45positive regulation of alpha-beta T cell proliferation (GO:0046641)3.18259572
46granulocyte activation (GO:0036230)3.18139688
47leukocyte degranulation (GO:0043299)3.14628963
48positive regulation of gamma-delta T cell activation (GO:0046645)3.08694633
49regulation of defense response to virus by virus (GO:0050690)3.08320147
50antigen receptor-mediated signaling pathway (GO:0050851)3.04710364
51negative regulation of T-helper cell differentiation (GO:0045623)3.04708014
52negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.04708014
53T cell receptor signaling pathway (GO:0050852)3.03968123
54regulation of platelet aggregation (GO:0090330)3.03031167
55dendritic cell migration (GO:0036336)3.01246872
56leukocyte migration involved in inflammatory response (GO:0002523)2.99589572
57regulation of leukocyte mediated cytotoxicity (GO:0001910)2.98986947
58pinocytosis (GO:0006907)2.97573535
59leukocyte aggregation (GO:0070486)2.96953456
60myeloid cell activation involved in immune response (GO:0002275)2.96303279
61neutrophil activation involved in immune response (GO:0002283)2.96003845
62negative regulation of phagocytosis (GO:0050765)2.95684208
63positive regulation of isotype switching (GO:0045830)2.93497339
64macrophage activation involved in immune response (GO:0002281)2.90610161
65positive regulation of interleukin-4 production (GO:0032753)2.90225643
66negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.90178995
67detection of external biotic stimulus (GO:0098581)2.87588389
68antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.87335038
69mast cell activation (GO:0045576)2.87113134
70positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.86834787
71negative regulation of interleukin-12 production (GO:0032695)2.86040900
72negative regulation of type 2 immune response (GO:0002829)2.86013414
73type I interferon signaling pathway (GO:0060337)2.85470334
74cellular response to type I interferon (GO:0071357)2.85470334
75response to type I interferon (GO:0034340)2.85012114
76central nervous system myelination (GO:0022010)2.84864841
77axon ensheathment in central nervous system (GO:0032291)2.84864841
78negative regulation of stress fiber assembly (GO:0051497)2.84675989
79positive regulation of mast cell activation (GO:0033005)2.84509075
80regulation of granulocyte differentiation (GO:0030852)2.81823021
81regulation of mast cell degranulation (GO:0043304)2.81815301
82regulation of leukocyte degranulation (GO:0043300)2.80869674
83L-phenylalanine catabolic process (GO:0006559)2.77581882
84erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.77581882
85regulation of myeloid leukocyte mediated immunity (GO:0002886)2.75774920
86ribosomal small subunit assembly (GO:0000028)2.75734732
87negative regulation of innate immune response (GO:0045824)2.75051955
88pyrimidine-containing compound transmembrane transport (GO:0072531)2.74111838
89regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.73392191
90T cell homeostasis (GO:0043029)2.73279633
91negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.72906817
92lymphocyte homeostasis (GO:0002260)2.72162706
93regulation of interleukin-2 biosynthetic process (GO:0045076)2.71615184
94regulation of T cell mediated immunity (GO:0002709)2.71387566
95positive regulation of natural killer cell mediated immunity (GO:0002717)2.68567208
96viral transcription (GO:0019083)2.67936443
97heme transport (GO:0015886)2.66829659
98response to laminar fluid shear stress (GO:0034616)2.66692076
99positive regulation of B cell differentiation (GO:0045579)2.65888382
100antigen processing and presentation via MHC class Ib (GO:0002475)2.64120063
101regulation of gamma-delta T cell differentiation (GO:0045586)2.64025802
102* amyloid precursor protein metabolic process (GO:0042982)2.63326441
103erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.63198952
104L-phenylalanine metabolic process (GO:0006558)2.63198952
105pentose-phosphate shunt (GO:0006098)2.61933344
106positive regulation of lipoprotein lipase activity (GO:0051006)2.53728023
107positive regulation of triglyceride lipase activity (GO:0061365)2.53728023
108translational termination (GO:0006415)2.50543487
109regulation of lipoprotein metabolic process (GO:0050746)2.50063762
110regulation of gamma-delta T cell activation (GO:0046643)2.47686012
111response to lipoprotein particle (GO:0055094)2.46515216
112definitive hemopoiesis (GO:0060216)2.46514047
113NADPH regeneration (GO:0006740)2.45879401
114protein carboxylation (GO:0018214)2.45636613
115peptidyl-glutamic acid carboxylation (GO:0017187)2.45636613
116plasma lipoprotein particle clearance (GO:0034381)2.44831775
117pentose metabolic process (GO:0019321)2.43346516
118response to muramyl dipeptide (GO:0032495)2.43119677
119adhesion of symbiont to host (GO:0044406)2.43059021
120respiratory burst (GO:0045730)2.41735654
121negative regulation of erythrocyte differentiation (GO:0045647)2.39915813
122creatine metabolic process (GO:0006600)2.36468135
123angiogenesis involved in wound healing (GO:0060055)2.35373414
124membrane protein intracellular domain proteolysis (GO:0031293)2.35303131
125ribosomal small subunit biogenesis (GO:0042274)2.29078740
126negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.27961299
127hemidesmosome assembly (GO:0031581)2.26552083
128very long-chain fatty acid metabolic process (GO:0000038)2.26470327
129sulfur amino acid catabolic process (GO:0000098)2.25965417
130regulation of superoxide anion generation (GO:0032928)2.24961465
131positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.24637701
132low-density lipoprotein particle clearance (GO:0034383)2.24011477
133regulation of cholesterol storage (GO:0010885)2.23891009
134membrane raft organization (GO:0031579)2.23348361
135fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.22415373
136negative regulation of viral entry into host cell (GO:0046597)2.19837655
137regulation of triglyceride catabolic process (GO:0010896)2.18451361
138fibrinolysis (GO:0042730)2.18420617
139killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.18322010
140disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.18322010
141defense response to fungus (GO:0050832)2.17966520
142primary alcohol catabolic process (GO:0034310)2.17708936
143aromatic amino acid family catabolic process (GO:0009074)2.17290129
144protein targeting to ER (GO:0045047)2.17128649
145positive regulation of triglyceride metabolic process (GO:0090208)2.17011446
146negative regulation of chemokine production (GO:0032682)2.15573251
147positive regulation of antigen processing and presentation (GO:0002579)2.14937092
148membrane protein ectodomain proteolysis (GO:0006509)2.14507257
149positive regulation by organism of defense response of other organism involved in symbiotic interact2.14047442
150modulation by symbiont of host immune response (GO:0052553)2.14047442
151positive regulation by symbiont of host defense response (GO:0052509)2.14047442
152modulation by symbiont of host defense response (GO:0052031)2.14047442
153modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.14047442
154modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.14047442
155ethanol metabolic process (GO:0006067)2.13811019
156SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.13561093
157immunoglobulin mediated immune response (GO:0016064)2.13407198
158positive regulation of cellular amine metabolic process (GO:0033240)2.13327014
159alpha-linolenic acid metabolic process (GO:0036109)2.13129315
160cotranslational protein targeting to membrane (GO:0006613)2.12871491
161Arp2/3 complex-mediated actin nucleation (GO:0034314)2.12626795
162cysteine metabolic process (GO:0006534)2.11546577
163bile acid and bile salt transport (GO:0015721)2.11058826
164establishment of protein localization to endoplasmic reticulum (GO:0072599)2.10633197
165megakaryocyte development (GO:0035855)2.09594016
166negative regulation of lipid storage (GO:0010888)2.07470907
167protein localization to endoplasmic reticulum (GO:0070972)2.06716549
168positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.06479020
169glyoxylate metabolic process (GO:0046487)2.06311837
170regulation of antigen processing and presentation (GO:0002577)2.05943137
171response to peptidoglycan (GO:0032494)2.05852601
172negative regulation of fibrinolysis (GO:0051918)2.05842759
173JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.05646357
174adhesion of symbiont to host cell (GO:0044650)2.05398604
175virion attachment to host cell (GO:0019062)2.05398604
176regulation of B cell differentiation (GO:0045577)2.04791806
177negative regulation of acute inflammatory response (GO:0002674)2.04609839

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.75692971
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.71297118
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.07276211
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.86804424
5SCL_19346495_ChIP-Seq_HPC-7_Human2.67321718
6* RXR_22158963_ChIP-Seq_LIVER_Mouse2.54735277
7PPARA_22158963_ChIP-Seq_LIVER_Mouse2.51432971
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.48284874
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.46049151
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.44413930
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.41705821
12EGR1_23403033_ChIP-Seq_LIVER_Mouse2.33132807
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.31886046
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.26602075
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.16944931
16VDR_21846776_ChIP-Seq_THP-1_Human2.12816024
17* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.08030113
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.04077171
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.00269061
20LXR_22158963_ChIP-Seq_LIVER_Mouse1.97182086
21IRF8_27001747_Chip-Seq_BMDM_Mouse1.95618513
22CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.94805480
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.92317067
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.89669261
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.88500095
26BP1_19119308_ChIP-ChIP_Hs578T_Human1.86139962
27BRD4_27068464_Chip-Seq_AML-cells_Mouse1.85719905
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.85113389
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.81447250
30STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.80142735
31GATA3_27048872_Chip-Seq_THYMUS_Human1.77427192
32SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.75191350
33LXR_22292898_ChIP-Seq_THP-1_Human1.73437814
34MAF_26560356_Chip-Seq_TH1_Human1.66817986
35VDR_24763502_ChIP-Seq_THP-1_Human1.66408343
36SPI1_23547873_ChIP-Seq_NB4_Human1.65251871
37* ELK3_25401928_ChIP-Seq_HUVEC_Human1.64620762
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63887898
39MYC_22102868_ChIP-Seq_BL_Human1.62850675
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.60658031
41STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.57057269
42RUNX_20019798_ChIP-Seq_JUKART_Human1.56060496
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.52595336
44STAT4_19710469_ChIP-ChIP_TH1__Mouse1.50083221
45GATA1_22383799_ChIP-Seq_G1ME_Mouse1.48591481
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.46843912
47E2F7_22180533_ChIP-Seq_HELA_Human1.46499141
48GATA1_22025678_ChIP-Seq_K562_Human1.42520079
49* KDM2B_26808549_Chip-Seq_JURKAT_Human1.40330487
50UTX_26944678_Chip-Seq_JUKART_Human1.38254417
51Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.37991721
52GATA1_19941826_ChIP-Seq_K562_Human1.37523631
53MYB_26560356_Chip-Seq_TH2_Human1.36300069
54MYB_26560356_Chip-Seq_TH1_Human1.36075368
55EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.35838149
56GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34666840
57MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.34060950
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32984737
59* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.32309132
60GATA2_21666600_ChIP-Seq_HMVEC_Human1.31095153
61* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27915164
62BCOR_27268052_Chip-Seq_Bcells_Human1.27767777
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27361144
64NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.27221414
65FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.26835645
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25792218
67* TCF7_22412390_ChIP-Seq_EML_Mouse1.25329237
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25241646
69* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24593659
70LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23849655
71* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.23627490
72* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22547675
73BCL6_27268052_Chip-Seq_Bcells_Human1.22547300
74* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.22451627
75TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21962435
76P63_26484246_Chip-Seq_KERATINOCYTES_Human1.21818161
77ELF1_17652178_ChIP-ChIP_JURKAT_Human1.21542290
78LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18246114
79SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.18232184
80* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18142630
81* MAF_26560356_Chip-Seq_TH2_Human1.17452537
82STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17345356
83* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16514533
84* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16443254
85IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15004020
86* GATA3_26560356_Chip-Seq_TH2_Human1.13715133
87* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12850686
88P68_20966046_ChIP-Seq_HELA_Human1.12601211
89SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12354422
90PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12023586
91GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11178634
92CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10838431
93GATA1_19941827_ChIP-Seq_MEL_Mouse1.10815467
94PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10050835
95* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09725486
96CLOCK_20551151_ChIP-Seq_293T_Human1.09458126
97ZNF263_19887448_ChIP-Seq_K562_Human1.08770311
98THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08693182
99* SPI1_23127762_ChIP-Seq_K562_Human1.08166935
100TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07746332
101SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07616496
102CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06759080
103ELF1_20517297_ChIP-Seq_JURKAT_Human1.06398239
104EGR1_19374776_ChIP-ChIP_THP-1_Human1.06345422
105RACK7_27058665_Chip-Seq_MCF-7_Human1.05302980
106SOX2_27498859_Chip-Seq_STOMACH_Mouse1.04623595
107PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03704394
108* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03637473
109ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03049453
110* SA1_27219007_Chip-Seq_ERYTHROID_Human1.02683406
111RARG_19884340_ChIP-ChIP_MEFs_Mouse1.02433451
112SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.02056474
113SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01871972
114CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99215710
115PU_27001747_Chip-Seq_BMDM_Mouse0.99100078
116FOXO3_23340844_ChIP-Seq_DLD1_Human0.98936102
117TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98710093
118SMAD_19615063_ChIP-ChIP_OVARY_Human0.97598168
119CTCF_21964334_ChIP-Seq_BJAB-B_Human0.97163566
120PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.96953775
121KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.96780346
122GATA2_19941826_ChIP-Seq_K562_Human0.95430556
123SPI1_20517297_ChIP-Seq_HL60_Human0.95104093
124NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.93556434
125SMC4_20622854_ChIP-Seq_HELA_Human0.93095703
126KDM2B_26808549_Chip-Seq_DND41_Human0.92911133
127* NCOR1_26117541_ChIP-Seq_K562_Human0.92631257
128* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92108801
129ESR2_21235772_ChIP-Seq_MCF-7_Human0.90524690
130ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90185094

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009840_abnormal_foam_cell2.63497620
2MP0005058_abnormal_lysosome_morphology2.44524436
3MP0003191_abnormal_cellular_cholesterol2.35654035
4MP0003724_increased_susceptibility_to2.09049761
5MP0003436_decreased_susceptibility_to2.09035007
6MP0000465_gastrointestinal_hemorrhage2.07323820
7MP0000703_abnormal_thymus_morphology2.02569054
8MP0002139_abnormal_hepatobiliary_system1.96855593
9MP0003806_abnormal_nucleotide_metabolis1.95498739
10MP0005360_urolithiasis1.95218364
11MP0000685_abnormal_immune_system1.94527750
12MP0009785_altered_susceptibility_to1.88062531
13MP0005464_abnormal_platelet_physiology1.87459988
14MP0001835_abnormal_antigen_presentation1.86568450
15MP0002419_abnormal_innate_immunity1.82790052
16MP0005025_abnormal_response_to1.77844513
17MP0003656_abnormal_erythrocyte_physiolo1.73685445
18MP0004381_abnormal_hair_follicle1.72770328
19MP0002396_abnormal_hematopoietic_system1.70130402
20MP0005365_abnormal_bile_salt1.69651334
21MP0003950_abnormal_plasma_membrane1.67708140
22MP0008875_abnormal_xenobiotic_pharmacok1.66953700
23MP0004947_skin_inflammation1.66490327
24MP0006082_CNS_inflammation1.65779607
25MP0008260_abnormal_autophagy1.61498248
26MP0000383_abnormal_hair_follicle1.60415957
27MP0005085_abnormal_gallbladder_physiolo1.60106399
28MP0005000_abnormal_immune_tolerance1.60003966
29MP0003566_abnormal_cell_adhesion1.56048528
30MP0001800_abnormal_humoral_immune1.52971975
31MP0004510_myositis1.52801846
32MP0008004_abnormal_stomach_pH1.52196026
33MP0005387_immune_system_phenotype1.51825582
34MP0001790_abnormal_immune_system1.51825582
35MP0002452_abnormal_antigen_presenting1.50405089
36MP0003303_peritoneal_inflammation1.50016834
37MP0002723_abnormal_immune_serum1.47337507
38MP0005671_abnormal_response_to1.46285200
39MP0002420_abnormal_adaptive_immunity1.44168088
40MP0003300_gastrointestinal_ulcer1.43720270
41MP0001819_abnormal_immune_cell1.42629331
42MP0003453_abnormal_keratinocyte_physiol1.42201603
43MP0000920_abnormal_myelination1.41832337
44MP0005451_abnormal_body_composition1.40892967
45MP0002148_abnormal_hypersensitivity_rea1.40790274
46MP0003828_pulmonary_edema1.40214404
47MP0001851_eye_inflammation1.39054116
48MP0010678_abnormal_skin_adnexa1.37904604
49MP0009333_abnormal_splenocyte_physiolog1.37577780
50MP0002796_impaired_skin_barrier1.35547200
51MP0010155_abnormal_intestine_physiology1.34409993
52MP0001873_stomach_inflammation1.34003129
53MP0009278_abnormal_bone_marrow1.31614178
54MP0005397_hematopoietic_system_phenotyp1.30420670
55MP0001545_abnormal_hematopoietic_system1.30420670
56MP0002166_altered_tumor_susceptibility1.29131559
57MP0001533_abnormal_skeleton_physiology1.27903261
58MP0002998_abnormal_bone_remodeling1.27846955
59MP0005075_abnormal_melanosome_morpholog1.27788724
60MP0004130_abnormal_muscle_cell1.26993978
61MP0005023_abnormal_wound_healing1.25418794
62MP0002060_abnormal_skin_morphology1.25316594
63MP0003763_abnormal_thymus_physiology1.24729560
64MP0005083_abnormal_biliary_tract1.23900051
65MP0000689_abnormal_spleen_morphology1.20886950
66MP0008469_abnormal_protein_level1.20759420
67MP0002398_abnormal_bone_marrow1.20188536
68MP0000716_abnormal_immune_system1.19851518
69MP0002933_joint_inflammation1.19251125
70MP0005310_abnormal_salivary_gland1.18909610
71MP0001845_abnormal_inflammatory_respons1.18854850
72MP0001666_abnormal_nutrient_absorption1.18846989
73MP0002722_abnormal_immune_system1.14820444
74MP0004185_abnormal_adipocyte_glucose1.14581317
75MP0002405_respiratory_system_inflammati1.14179303
76MP0003186_abnormal_redox_activity1.13069380
77MP0000609_abnormal_liver_physiology1.13054011
78MP0006054_spinal_hemorrhage1.12502733
79MP0001216_abnormal_epidermal_layer1.12464455
80MP0002429_abnormal_blood_cell1.10251391
81MP0001853_heart_inflammation1.09349947
82MP0004883_abnormal_blood_vessel1.09280787
83MP0002132_abnormal_respiratory_system1.08740545
84MP0003183_abnormal_peptide_metabolism1.05334947
85MP0002098_abnormal_vibrissa_morphology1.05029012
86MP0000377_abnormal_hair_follicle1.02617779
87* MP0010329_abnormal_lipoprotein_level1.02420380
88MP0009763_increased_sensitivity_to1.01021819
89MP0005501_abnormal_skin_physiology1.00819445
90MP0008438_abnormal_cutaneous_collagen0.98969398
91MP0003705_abnormal_hypodermis_morpholog0.98359300
92MP0003195_calcinosis0.95867806
93MP0000015_abnormal_ear_pigmentation0.93726896
94MP0003045_fibrosis0.92417759
95MP0001663_abnormal_digestive_system0.91804226
96MP0000490_abnormal_crypts_of0.90434791
97MP0001243_abnormal_dermal_layer0.89755923
98MP0009643_abnormal_urine_homeostasis0.89614309
99MP0008874_decreased_physiological_sensi0.88912999
100MP0010368_abnormal_lymphatic_system0.88791060
101MP0005167_abnormal_blood-brain_barrier0.88499607
102* MP0002118_abnormal_lipid_homeostasis0.88181002
103MP0009931_abnormal_skin_appearance0.87104760
104MP0001765_abnormal_ion_homeostasis0.85384953
105MP0000858_altered_metastatic_potential0.85246710
106MP0009764_decreased_sensitivity_to0.84967013
107MP0004147_increased_porphyrin_level0.84485116
108MP0003172_abnormal_lysosome_physiology0.84430720
109MP0003866_abnormal_defecation0.84221891
110MP0003448_altered_tumor_morphology0.84012308
111MP0000598_abnormal_liver_morphology0.82954180
112MP0003075_altered_response_to0.82723727
113MP0009765_abnormal_xenobiotic_induced0.82103999
114MP0003690_abnormal_glial_cell0.81978981
115MP0004808_abnormal_hematopoietic_stem0.81408938
116MP0003252_abnormal_bile_duct0.79967803
117MP0005166_decreased_susceptibility_to0.79302716
118MP0000249_abnormal_blood_vessel0.78705497
119MP0000343_altered_response_to0.77474341
120MP0002277_abnormal_respiratory_mucosa0.75045966
121MP0003795_abnormal_bone_structure0.74673885
122MP0005164_abnormal_response_to0.74400033
123MP0005390_skeleton_phenotype0.73842345
124MP0000604_amyloidosis0.73359162
125MP0002693_abnormal_pancreas_physiology0.71599775
126MP0003091_abnormal_cell_migration0.67717387
127MP0001986_abnormal_taste_sensitivity0.66755950
128MP0003638_abnormal_response/metabolism_0.65989090
129MP0003879_abnormal_hair_cell0.63590926
130MP0008961_abnormal_basal_metabolism0.60340696
131* MP0009642_abnormal_blood_homeostasis0.60114282
132MP0002009_preneoplasia0.59421650
133MP0005409_darkened_coat_color0.59126697
134MP0001849_ear_inflammation0.58847268
135MP0003329_amyloid_beta_deposits0.58758046
136MP0005381_digestive/alimentary_phenotyp0.57889064

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)3.89565551
2Vacuolated lymphocytes (HP:0001922)3.75282501
3Abnormal delayed hypersensitivity skin test (HP:0002963)3.71843204
4Gastrointestinal infarctions (HP:0005244)3.57421160
5Abnormality of T cell number (HP:0011839)3.52791474
6Recurrent abscess formation (HP:0002722)3.52741743
7Chronic otitis media (HP:0000389)3.51734072
8Orchitis (HP:0100796)3.47875204
9Abnormality of macrophages (HP:0004311)3.42636221
10Encephalitis (HP:0002383)3.27779778
11Panhypogammaglobulinemia (HP:0003139)3.25489002
12Recurrent bacterial skin infections (HP:0005406)3.23221906
13Inflammation of the large intestine (HP:0002037)3.22233140
14Gastrointestinal inflammation (HP:0004386)3.20760935
15Retrobulbar optic neuritis (HP:0100654)3.20721422
16Optic neuritis (HP:0100653)3.20721422
17Axonal loss (HP:0003447)3.17294600
18Eczematoid dermatitis (HP:0000976)3.16773898
19Abnormality of T cells (HP:0002843)3.14807536
20Intrahepatic cholestasis (HP:0001406)3.13268621
21Meningitis (HP:0001287)3.09871813
22Pustule (HP:0200039)3.06993874
23Deep venous thrombosis (HP:0002625)2.95484751
24Elevated erythrocyte sedimentation rate (HP:0003565)2.86142880
25Recurrent cutaneous fungal infections (HP:0011370)2.83350930
26Chronic mucocutaneous candidiasis (HP:0002728)2.83350930
27Increased cerebral lipofuscin (HP:0011813)2.78475300
28Spontaneous hematomas (HP:0007420)2.75103455
29Epistaxis (HP:0000421)2.74634272
30Petechiae (HP:0000967)2.74488874
31Gingival bleeding (HP:0000225)2.73856084
32Increased IgM level (HP:0003496)2.73056848
33Abnormality of aromatic amino acid family metabolism (HP:0004338)2.72791460
34Joint hemorrhage (HP:0005261)2.72103821
35Increased neuronal autofluorescent lipopigment (HP:0002074)2.71931141
36Episodic fever (HP:0001954)2.69354822
37Chest pain (HP:0100749)2.68871528
38Mediastinal lymphadenopathy (HP:0100721)2.68415092
39Hepatosplenomegaly (HP:0001433)2.66188334
40Prolonged partial thromboplastin time (HP:0003645)2.64204539
41Recurrent skin infections (HP:0001581)2.63693156
42Increased serum ferritin (HP:0003281)2.59271338
43Recurrent gram-negative bacterial infections (HP:0005420)2.58730602
44Gingivitis (HP:0000230)2.57461527
45Abnormality of monocarboxylic acid metabolism (HP:0010996)2.55203763
46Prolonged bleeding time (HP:0003010)2.53046634
47Stomatitis (HP:0010280)2.50457261
48Colitis (HP:0002583)2.48581988
49* Xanthomatosis (HP:0000991)2.47675804
50Hypochromic microcytic anemia (HP:0004840)2.47322460
51Abnormality of iron homeostasis (HP:0011031)2.46963741
52Hypochromic anemia (HP:0001931)2.46308088
53Lymphopenia (HP:0001888)2.45253597
54Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.42079017
55Autoimmune hemolytic anemia (HP:0001890)2.39446032
56Purpura (HP:0000979)2.38233490
57Thoracic kyphosis (HP:0002942)2.37473706
58Abnormal platelet function (HP:0011869)2.36814350
59Impaired platelet aggregation (HP:0003540)2.36814350
60Thick nail (HP:0001805)2.36377477
61Pulmonary infiltrates (HP:0002113)2.36238388
62Loss of speech (HP:0002371)2.36115345
63Papilledema (HP:0001085)2.35196001
64Premature skin wrinkling (HP:0100678)2.32951044
65Slow saccadic eye movements (HP:0000514)2.31080263
66Parakeratosis (HP:0001036)2.30073020
67Myocardial infarction (HP:0001658)2.30043991
68Keratoconjunctivitis sicca (HP:0001097)2.29224701
69Thrombocytosis (HP:0001894)2.28550508
70Abnormality of cells of the erythroid lineage (HP:0012130)2.26585005
71Menorrhagia (HP:0000132)2.26327339
72Severe combined immunodeficiency (HP:0004430)2.25546802
73Abnormality of cells of the lymphoid lineage (HP:0012140)2.24774053
74Papilloma (HP:0012740)2.24406171
75Verrucae (HP:0200043)2.24406171
76* Hyperlipoproteinemia (HP:0010980)2.21700666
77Cellulitis (HP:0100658)2.20009772
78Systemic lupus erythematosus (HP:0002725)2.19164517
79Interstitial pulmonary disease (HP:0006530)2.17675967
80Anorexia (HP:0002039)2.14972907
81Abnormal number of erythroid precursors (HP:0012131)2.14862570
82Microcytic anemia (HP:0001935)2.14402267
83Esophageal varix (HP:0002040)2.12716177
84Arterial thrombosis (HP:0004420)2.11943293
85Abnormality of the nasal mucosa (HP:0000433)2.11581250
86Abnormality of transition element cation homeostasis (HP:0011030)2.10846016
87Complement deficiency (HP:0004431)2.10626635
88Osteolytic defects of the phalanges of the hand (HP:0009771)2.10046098
89Osteolytic defects of the hand bones (HP:0009699)2.10046098
90Joint swelling (HP:0001386)2.09870255
91Keratoconjunctivitis (HP:0001096)2.09823292
92Amyloidosis (HP:0011034)2.08083800
93IgM deficiency (HP:0002850)2.07219646
94Hypergammaglobulinemia (HP:0010702)2.07219178
95Agammaglobulinemia (HP:0004432)2.06514292
96Myositis (HP:0100614)2.06252209
97Hemoptysis (HP:0002105)2.06175933
98IgG deficiency (HP:0004315)2.05958824
99Bruising susceptibility (HP:0000978)2.04812798
100Hemorrhage of the eye (HP:0011885)2.03366868
101Recurrent viral infections (HP:0004429)2.02501908
102Hypertensive crisis (HP:0100735)2.01839154
103Abnormal platelet volume (HP:0011876)2.01801629
104Periodontitis (HP:0000704)1.99706683
105Recurrent fungal infections (HP:0002841)1.99562793
106Obstructive lung disease (HP:0006536)1.98436752
107Chronic obstructive pulmonary disease (HP:0006510)1.98436752
108Glomerulonephritis (HP:0000099)1.98295001
109Acute hepatic failure (HP:0006554)1.97895885
110Urticaria (HP:0001025)1.97522896
111Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.97458963
112Autoimmune thrombocytopenia (HP:0001973)1.96485223
113Seborrheic dermatitis (HP:0001051)1.95963325
114Leukocytosis (HP:0001974)1.95284778
115Increased IgE level (HP:0003212)1.93185625
116Abnormality of the common coagulation pathway (HP:0010990)1.92910832
117Skin ulcer (HP:0200042)1.92108025
118Dysostosis multiplex (HP:0000943)1.91631230
119Acne (HP:0001061)1.90847184
120Abnormality of complement system (HP:0005339)1.89256235
121Gastrointestinal stroma tumor (HP:0100723)1.88769088
122Steatorrhea (HP:0002570)1.87878576
123Pulmonary embolism (HP:0002204)1.87654471
124Osteomyelitis (HP:0002754)1.87447863
125Ectropion (HP:0000656)1.87158952
126Increased mean platelet volume (HP:0011877)1.87001592
127Abnormality of fatty-acid metabolism (HP:0004359)1.85841811
128Congenital ichthyosiform erythroderma (HP:0007431)1.85682938
129Nasal polyposis (HP:0100582)1.84731966
130Premature rupture of membranes (HP:0001788)1.83582701
131Eosinophilia (HP:0001880)1.82352716
132Polycythemia (HP:0001901)1.82242538
133Fat malabsorption (HP:0002630)1.82188562
134Chronic diarrhea (HP:0002028)1.81910097
135Abnormality of eosinophils (HP:0001879)1.81633446
136Nonimmune hydrops fetalis (HP:0001790)1.80008067
137Alopecia of scalp (HP:0002293)1.78421499
138Abnormality of T cell physiology (HP:0011840)1.78373011
139Sepsis (HP:0100806)1.78131684
140Obstructive sleep apnea (HP:0002870)1.77145421
141Vasculitis (HP:0002633)1.76944682
142Recurrent bronchitis (HP:0002837)1.75958249
143Abnormality of the vasculature of the conjunctiva (HP:0008054)1.75536099
144Erythroderma (HP:0001019)1.74319158
145Nephritis (HP:0000123)1.73301936
146Granulocytopenia (HP:0001913)1.72626341
147Abnormality of the thoracic spine (HP:0100711)1.72115903
148Abnormality of methionine metabolism (HP:0010901)1.71760869
149Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.71722483
150Peripheral demyelination (HP:0011096)1.71532972
151Macrocytic anemia (HP:0001972)1.71437884
152Hypotrichosis (HP:0001006)1.71308105
153Ulnar bowing (HP:0003031)1.69928779
154Stridor (HP:0010307)1.69562040
155Pruritus (HP:0000989)1.65800359
156Ileus (HP:0002595)1.65389533

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.27573496
2EPHB13.57979207
3PRPF4B2.96242016
4MAP4K12.94741363
5MST1R2.67668585
6TAOK32.46139989
7FES2.28968161
8TNK22.27914577
9NME22.21510508
10ERN12.18317587
11KIT2.10298350
12BLK2.02679967
13MAP2K31.97484474
14STK101.96675355
15KDR1.92904356
16TGFBR21.86844828
17MET1.82707462
18MAP3K131.81728942
19TBK11.77176306
20FGFR41.75981650
21TYK21.73444260
22EEF2K1.63433127
23BTK1.59249812
24MAPKAPK51.54878035
25MAP2K21.52528088
26IKBKE1.49840685
27TAOK11.48609775
28BCKDK1.48509780
29IRAK41.43390231
30CLK11.42395103
31MAP3K31.41940509
32TIE11.40942022
33JAK31.40518758
34ITK1.40250153
35PIM21.38547437
36LRRK21.34504576
37TEC1.33796399
38SIK31.30757184
39CSF1R1.28423520
40STK391.28171514
41RPS6KB21.27211830
42BMX1.26666459
43ZAP701.25382982
44SMG11.19711699
45IKBKB1.18180908
46NLK1.17869275
47TRPM71.17549139
48TAOK21.17451802
49EPHA21.12302017
50PIK3CA1.07667263
51FLT31.06645441
52MARK31.06348387
53KSR21.04796935
54TGFBR11.03670027
55CAMKK11.03386812
56PKN21.03258293
57MAP3K71.03076467
58SIK11.02641957
59PASK1.02491828
60PDK11.02449403
61STK41.02436283
62MARK21.01846991
63FGR1.01812200
64TRIB31.01338665
65TESK20.99643790
66CAMKK20.98440046
67TTN0.98328605
68MAP3K140.97008595
69CSK0.95684165
70TXK0.95225107
71PRKD20.93768914
72LCK0.93607853
73PIM10.93113043
74PTK2B0.90176697
75PDPK10.88750629
76FGFR30.88196216
77CDK120.86649451
78RPS6KA40.85211585
79HIPK20.84770007
80CDC42BPA0.84768704
81IRAK30.84708009
82MAP3K80.83692745
83PAK40.83360792
84PTK60.80881000
85HCK0.79789744
86YES10.78812208
87STK380.77754591
88PBK0.76608997
89GRK60.74684414
90MAP3K110.73410149
91JAK20.70226009
92EPHA30.70154088
93SYK0.68867093
94RPS6KA50.68718386
95MST40.68696108
96WEE10.68418701
97OXSR10.66997912
98LYN0.66322976
99CDK40.65544514
100FGFR20.64969082
101MAP2K60.62931040
102MAPK150.62084250
103MAP3K100.60890012
104CDK60.60617312
105SIK20.58990340
106FYN0.58331693
107CDK190.57687143
108MAP3K20.57202044
109PIK3CG0.56882787
110BMPR20.56762190
111MAPK40.56365897
112MAPKAPK30.56342517
113MAPK70.54894760
114BUB10.54375551
115JAK10.53723797
116MAPK110.53206785
117IRAK20.50920196
118MAPKAPK20.50544276
119MAP3K10.50348208
120PRKG20.50023243
121RET0.49543727
122SGK30.48846310
123CSNK1A1L0.46758699
124CSNK1G30.46422745
125PAK20.46058814
126MAPK120.44341162
127CSNK1G10.43963690
128GRK50.43549841
129PKN10.43297602
130RIPK10.43296927
131DYRK30.42736446
132ABL10.42620629
133NEK90.41073137
134PRKCQ0.40478857
135PRKD10.40260288
136ARAF0.39531424
137CDK70.38605496
138PLK40.36807649
139RPS6KA60.36190703
140ILK0.35253348
141MELK0.34974604
142RAF10.33223850
143DYRK1B0.33121466
144IRAK10.31400553
145PDGFRB0.31387723
146ICK0.30638884

Predicted pathways (KEGG)

RankGene SetZ-score
1Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.47655124
2Fatty acid elongation_Homo sapiens_hsa000622.37133167
3Staphylococcus aureus infection_Homo sapiens_hsa051502.28428213
4Steroid biosynthesis_Homo sapiens_hsa001002.23690740
5Caffeine metabolism_Homo sapiens_hsa002322.04031221
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.03766362
7Histidine metabolism_Homo sapiens_hsa003401.96480307
8Complement and coagulation cascades_Homo sapiens_hsa046101.91503243
9Chemokine signaling pathway_Homo sapiens_hsa040621.82988523
10Graft-versus-host disease_Homo sapiens_hsa053321.82595671
11Allograft rejection_Homo sapiens_hsa053301.80307662
12Autoimmune thyroid disease_Homo sapiens_hsa053201.78536329
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.72886195
14Folate biosynthesis_Homo sapiens_hsa007901.68037707
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.64595103
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.64231621
17Ribosome_Homo sapiens_hsa030101.61343050
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.57209244
19Non-small cell lung cancer_Homo sapiens_hsa052231.50058410
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.43930872
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.43000509
22Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.41492780
23Leishmaniasis_Homo sapiens_hsa051401.40654589
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.40350692
25Type I diabetes mellitus_Homo sapiens_hsa049401.39661974
26Tuberculosis_Homo sapiens_hsa051521.37156663
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.36084590
28Other glycan degradation_Homo sapiens_hsa005111.35438421
29Chemical carcinogenesis_Homo sapiens_hsa052041.34972758
30Vitamin B6 metabolism_Homo sapiens_hsa007501.29832088
31VEGF signaling pathway_Homo sapiens_hsa043701.28803442
32Sulfur relay system_Homo sapiens_hsa041221.28604107
33Primary immunodeficiency_Homo sapiens_hsa053401.26607089
34Viral myocarditis_Homo sapiens_hsa054161.26445917
35ABC transporters_Homo sapiens_hsa020101.24241828
36B cell receptor signaling pathway_Homo sapiens_hsa046621.23695889
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.23582264
38Vitamin digestion and absorption_Homo sapiens_hsa049771.22829577
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21685073
40Lysosome_Homo sapiens_hsa041421.19710736
41NF-kappa B signaling pathway_Homo sapiens_hsa040641.17767482
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.16557745
43Fatty acid degradation_Homo sapiens_hsa000711.15794421
44Pancreatic cancer_Homo sapiens_hsa052121.15687738
45Glutathione metabolism_Homo sapiens_hsa004801.15672151
46PPAR signaling pathway_Homo sapiens_hsa033201.12995446
47Peroxisome_Homo sapiens_hsa041461.12892202
48SNARE interactions in vesicular transport_Homo sapiens_hsa041301.12656227
49* Endocytosis_Homo sapiens_hsa041441.10996521
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.09948734
51Chronic myeloid leukemia_Homo sapiens_hsa052201.09341267
52Pentose phosphate pathway_Homo sapiens_hsa000301.08373413
53beta-Alanine metabolism_Homo sapiens_hsa004101.07366070
54TNF signaling pathway_Homo sapiens_hsa046681.06632514
55Osteoclast differentiation_Homo sapiens_hsa043801.04969120
56Malaria_Homo sapiens_hsa051441.04408653
57Hematopoietic cell lineage_Homo sapiens_hsa046401.03819795
58Nitrogen metabolism_Homo sapiens_hsa009101.03717593
59Drug metabolism - other enzymes_Homo sapiens_hsa009831.02521647
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.02235199
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.99705166
62Influenza A_Homo sapiens_hsa051640.98511559
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.98388345
64Glycosaminoglycan degradation_Homo sapiens_hsa005310.97364578
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.96978719
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96888198
67Endometrial cancer_Homo sapiens_hsa052130.95137350
68Hepatitis B_Homo sapiens_hsa051610.94487855
69Sulfur metabolism_Homo sapiens_hsa009200.94385756
70Linoleic acid metabolism_Homo sapiens_hsa005910.93736796
71Inositol phosphate metabolism_Homo sapiens_hsa005620.92116509
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91966958
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91815340
74Renal cell carcinoma_Homo sapiens_hsa052110.91136999
75Retinol metabolism_Homo sapiens_hsa008300.90240828
76Sphingolipid metabolism_Homo sapiens_hsa006000.90134815
77Ether lipid metabolism_Homo sapiens_hsa005650.89720317
78Choline metabolism in cancer_Homo sapiens_hsa052310.87068287
79Tryptophan metabolism_Homo sapiens_hsa003800.86404138
80Acute myeloid leukemia_Homo sapiens_hsa052210.86136946
81Pertussis_Homo sapiens_hsa051330.86102439
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85718099
83Phagosome_Homo sapiens_hsa041450.84317053
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.83291148
85Thyroid cancer_Homo sapiens_hsa052160.82717672
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82274012
87Measles_Homo sapiens_hsa051620.82028152
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80215955
89Fatty acid metabolism_Homo sapiens_hsa012120.79922286
90Arginine and proline metabolism_Homo sapiens_hsa003300.78504712
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78316316
92Toxoplasmosis_Homo sapiens_hsa051450.77641733
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.77348328
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77168184
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.76566641
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76512477
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.76382853
98Hepatitis C_Homo sapiens_hsa051600.76012776
99mTOR signaling pathway_Homo sapiens_hsa041500.75767835
100Notch signaling pathway_Homo sapiens_hsa043300.75717791
101Antigen processing and presentation_Homo sapiens_hsa046120.75538934
102RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75103505
103Fat digestion and absorption_Homo sapiens_hsa049750.74316588
104AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73686037
105Insulin resistance_Homo sapiens_hsa049310.71119931
106Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70567007
107FoxO signaling pathway_Homo sapiens_hsa040680.69782198
108Shigellosis_Homo sapiens_hsa051310.69538238
109Selenocompound metabolism_Homo sapiens_hsa004500.68939009
110Apoptosis_Homo sapiens_hsa042100.68523159
111Platelet activation_Homo sapiens_hsa046110.68238892
112Arachidonic acid metabolism_Homo sapiens_hsa005900.68110448
113NOD-like receptor signaling pathway_Homo sapiens_hsa046210.67490162
114Glycerolipid metabolism_Homo sapiens_hsa005610.66698774
115GnRH signaling pathway_Homo sapiens_hsa049120.66314345
116Rap1 signaling pathway_Homo sapiens_hsa040150.66074248
117Viral carcinogenesis_Homo sapiens_hsa052030.65896068
118Arginine biosynthesis_Homo sapiens_hsa002200.65510426
119ECM-receptor interaction_Homo sapiens_hsa045120.65308260
120Jak-STAT signaling pathway_Homo sapiens_hsa046300.64797819
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64665528
122Small cell lung cancer_Homo sapiens_hsa052220.64524247
123Colorectal cancer_Homo sapiens_hsa052100.64371011
124Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.63906492
125African trypanosomiasis_Homo sapiens_hsa051430.63514508
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62240674
127Propanoate metabolism_Homo sapiens_hsa006400.62019170
128Herpes simplex infection_Homo sapiens_hsa051680.60502753
129Legionellosis_Homo sapiens_hsa051340.59506409
130Long-term potentiation_Homo sapiens_hsa047200.59499051
131Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59208948
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59123613
133Cyanoamino acid metabolism_Homo sapiens_hsa004600.58624177
134Prolactin signaling pathway_Homo sapiens_hsa049170.57377500
135HTLV-I infection_Homo sapiens_hsa051660.56366101
136T cell receptor signaling pathway_Homo sapiens_hsa046600.54918369
137Ras signaling pathway_Homo sapiens_hsa040140.54635713
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54148186
139Vascular smooth muscle contraction_Homo sapiens_hsa042700.54063001
140Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52949048
141Cysteine and methionine metabolism_Homo sapiens_hsa002700.52880380
142ErbB signaling pathway_Homo sapiens_hsa040120.52159118
143MAPK signaling pathway_Homo sapiens_hsa040100.51805290
144Insulin signaling pathway_Homo sapiens_hsa049100.51676062
145Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49747391
146Prostate cancer_Homo sapiens_hsa052150.48728239
147Salmonella infection_Homo sapiens_hsa051320.48555852
148Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48310494
149Amoebiasis_Homo sapiens_hsa051460.47617158
150Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47263978
151Starch and sucrose metabolism_Homo sapiens_hsa005000.47178061
152Glioma_Homo sapiens_hsa052140.46100664
153Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45432947
154Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43898866
155Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43777019
156Type II diabetes mellitus_Homo sapiens_hsa049300.42699627
157Glycerophospholipid metabolism_Homo sapiens_hsa005640.42506874
158Bile secretion_Homo sapiens_hsa049760.42317405
159Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42050972
160DNA replication_Homo sapiens_hsa030300.41920131
161Protein export_Homo sapiens_hsa030600.41377530

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