LDOC1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.71131995
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.60240097
3synaptic vesicle maturation (GO:0016188)5.55052901
4synaptic vesicle exocytosis (GO:0016079)5.38404853
5locomotory exploration behavior (GO:0035641)5.16493829
6vocalization behavior (GO:0071625)5.01710604
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.00610875
8regulation of synaptic vesicle exocytosis (GO:2000300)4.87009710
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.85066812
10protein localization to synapse (GO:0035418)4.81869244
11glutamate secretion (GO:0014047)4.79489732
12neuron cell-cell adhesion (GO:0007158)4.77311049
13layer formation in cerebral cortex (GO:0021819)4.61268756
14regulation of glutamate receptor signaling pathway (GO:1900449)4.47081357
15exploration behavior (GO:0035640)4.46414679
16synaptic vesicle docking involved in exocytosis (GO:0016081)4.43627778
17dendritic spine morphogenesis (GO:0060997)4.32154834
18regulation of synaptic vesicle transport (GO:1902803)4.28150190
19regulation of neuronal synaptic plasticity (GO:0048168)4.10251504
20regulation of synapse structural plasticity (GO:0051823)4.09219299
21ionotropic glutamate receptor signaling pathway (GO:0035235)4.07968531
22neurotransmitter secretion (GO:0007269)4.03944275
23regulation of long-term neuronal synaptic plasticity (GO:0048169)3.97975690
24neuron recognition (GO:0008038)3.97679361
25presynaptic membrane assembly (GO:0097105)3.80439121
26axonal fasciculation (GO:0007413)3.77114662
27synaptic transmission, glutamatergic (GO:0035249)3.76826894
28neuronal action potential propagation (GO:0019227)3.72910923
29positive regulation of synapse maturation (GO:0090129)3.71989912
30glutamate receptor signaling pathway (GO:0007215)3.62857200
31neuron-neuron synaptic transmission (GO:0007270)3.61099814
32regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.58248463
33cell migration in hindbrain (GO:0021535)3.54696424
34regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.54305269
35positive regulation of synaptic transmission, GABAergic (GO:0032230)3.50836488
36positive regulation of membrane potential (GO:0045838)3.50671087
37negative regulation of microtubule polymerization (GO:0031115)3.50027179
38response to pheromone (GO:0019236)3.49291253
39dendrite morphogenesis (GO:0048813)3.48790842
40presynaptic membrane organization (GO:0097090)3.37871724
41synaptic vesicle endocytosis (GO:0048488)3.37586206
42innervation (GO:0060384)3.36213205
43regulation of excitatory postsynaptic membrane potential (GO:0060079)3.36025766
44planar cell polarity pathway involved in neural tube closure (GO:0090179)3.35651028
45long-term memory (GO:0007616)3.35478392
46activation of protein kinase A activity (GO:0034199)3.34175563
47regulation of dendritic spine morphogenesis (GO:0061001)3.31781823
48auditory behavior (GO:0031223)3.30970778
49neurotransmitter-gated ion channel clustering (GO:0072578)3.30776780
50regulation of vesicle fusion (GO:0031338)3.28937799
51regulation of postsynaptic membrane potential (GO:0060078)3.26593642
52neurotransmitter transport (GO:0006836)3.25571954
53regulation of synaptic plasticity (GO:0048167)3.24405266
54prepulse inhibition (GO:0060134)3.24179448
55membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.22925201
56regulation of neurotransmitter secretion (GO:0046928)3.22818647
57G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.21286548
58transmission of nerve impulse (GO:0019226)3.20873367
59proline transport (GO:0015824)3.20539262
60cellular potassium ion homeostasis (GO:0030007)3.19879133
61response to auditory stimulus (GO:0010996)3.18861925
62postsynaptic membrane organization (GO:0001941)3.18033326
63cerebellar Purkinje cell differentiation (GO:0021702)3.14387813
64long-term synaptic potentiation (GO:0060291)3.13555008
65regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.12412569
66central nervous system projection neuron axonogenesis (GO:0021952)3.11365264
67axon extension (GO:0048675)3.10823840
68positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.09862241
69paraxial mesoderm development (GO:0048339)3.09811972
70neuronal ion channel clustering (GO:0045161)3.09694353
71gamma-aminobutyric acid transport (GO:0015812)3.09348957
72neuromuscular process controlling balance (GO:0050885)3.07022555
73dendritic spine organization (GO:0097061)3.06553295
74membrane depolarization during action potential (GO:0086010)3.05022069
75cell communication by electrical coupling (GO:0010644)3.04654238
76positive regulation of dendritic spine morphogenesis (GO:0061003)3.03845130
77regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.99802023
78detection of calcium ion (GO:0005513)2.99721190
79regulation of neurotransmitter transport (GO:0051588)2.98742052
80gamma-aminobutyric acid signaling pathway (GO:0007214)2.97958542
81synapse assembly (GO:0007416)2.97550741
82regulation of neurotransmitter levels (GO:0001505)2.97041556
83sodium ion export (GO:0071436)2.96649590
84regulation of synaptic transmission, glutamatergic (GO:0051966)2.96477927
85calcium ion-dependent exocytosis (GO:0017156)2.95581969
86cerebellar Purkinje cell layer development (GO:0021680)2.94335623
87behavioral fear response (GO:0001662)2.93676652
88behavioral defense response (GO:0002209)2.93676652
89membrane hyperpolarization (GO:0060081)2.92693305
90adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.91961562
91apical protein localization (GO:0045176)2.91566874
92positive regulation of neurotransmitter secretion (GO:0001956)2.91126829
93nucleobase catabolic process (GO:0046113)2.90309309
94membrane depolarization (GO:0051899)2.89952870
95positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.88989321
96regulation of ARF protein signal transduction (GO:0032012)2.88939939
97vesicle transport along microtubule (GO:0047496)2.88891741
98cerebellum development (GO:0021549)2.88322959
99establishment of nucleus localization (GO:0040023)2.88283371
100mating behavior (GO:0007617)2.88133669
101positive regulation of dendritic spine development (GO:0060999)2.87783382
102regulation of synapse maturation (GO:0090128)2.86812136
103positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.86436927
104intraspecies interaction between organisms (GO:0051703)2.86374898
105social behavior (GO:0035176)2.86374898
106learning (GO:0007612)2.86252572
107pyrimidine nucleobase catabolic process (GO:0006208)2.85842081
108positive regulation of neurotransmitter transport (GO:0051590)2.85444621
109synapse organization (GO:0050808)2.85093932
110neuron projection extension involved in neuron projection guidance (GO:1902284)2.81571004
111axon extension involved in axon guidance (GO:0048846)2.81571004
112neuron projection extension (GO:1990138)2.80711421
113establishment of mitochondrion localization (GO:0051654)2.77971032
114regulation of axon extension involved in axon guidance (GO:0048841)2.71476110
115regulation of axon guidance (GO:1902667)2.70258748
116regulation of NFAT protein import into nucleus (GO:0051532)2.69117364
117Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.64228882
118cerebellar granule cell differentiation (GO:0021707)2.56631532
119asymmetric protein localization (GO:0008105)2.55055527
120regulation of establishment of planar polarity (GO:0090175)2.53189044
121ganglion development (GO:0061548)2.50313765
122generation of neurons (GO:0048699)2.47226905
123cytoskeletal anchoring at plasma membrane (GO:0007016)2.46137554
124cerebral cortex radially oriented cell migration (GO:0021799)2.45275479
125developmental cell growth (GO:0048588)2.42182708
126convergent extension (GO:0060026)2.41896813
127dermatan sulfate biosynthetic process (GO:0030208)2.41656739
128positive regulation of synapse assembly (GO:0051965)2.39042721
129cranial nerve morphogenesis (GO:0021602)2.38995275
130camera-type eye morphogenesis (GO:0048593)2.38808565
131establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.37199222
132mitochondrion transport along microtubule (GO:0047497)2.37199222
133negative regulation of catenin import into nucleus (GO:0035414)2.30697638
134protein heterotrimerization (GO:0070208)2.28974759
135cochlea morphogenesis (GO:0090103)2.27252512
136membrane assembly (GO:0071709)2.25862801
137negative regulation of axonogenesis (GO:0050771)2.24503014
138dermatan sulfate metabolic process (GO:0030205)2.24297360
139ephrin receptor signaling pathway (GO:0048013)2.21204895
140morphogenesis of an epithelial sheet (GO:0002011)2.20895616
141suckling behavior (GO:0001967)2.19926343
142negative regulation of axon guidance (GO:1902668)2.19182691
143spinal cord development (GO:0021510)2.19135384
144amino acid import (GO:0043090)2.17479878
145lens morphogenesis in camera-type eye (GO:0002089)2.16404343
146negative regulation of dendrite morphogenesis (GO:0050774)2.16016984
147central nervous system neuron axonogenesis (GO:0021955)2.15787917
148negative regulation of chondrocyte differentiation (GO:0032331)2.15562419
149developmental growth involved in morphogenesis (GO:0060560)2.14511388
150regulation of respiratory system process (GO:0044065)2.14405314
151non-canonical Wnt signaling pathway (GO:0035567)2.13340439
152negative regulation of axon extension (GO:0030517)2.13322715
153peripheral nervous system axon ensheathment (GO:0032292)2.12588758
154myelination in peripheral nervous system (GO:0022011)2.12588758
155Notch signaling involved in heart development (GO:0061314)2.11428934
156semaphorin-plexin signaling pathway (GO:0071526)2.10143153
157negative regulation of axon extension involved in axon guidance (GO:0048843)2.09861393
158regulation of synapse assembly (GO:0051963)2.08908400
159cellular protein complex localization (GO:0034629)2.07817164
160calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.07511394
161dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.07039983
162negative regulation of neuron projection development (GO:0010977)2.05685537

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.57149303
2JARID2_20064375_ChIP-Seq_MESCs_Mouse3.05988845
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.98677701
4GBX2_23144817_ChIP-Seq_PC3_Human2.97732863
5* REST_21632747_ChIP-Seq_MESCs_Mouse2.96870925
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.81173611
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.76219024
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.66759789
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.65895104
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.62549922
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.62549922
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.54428402
13EZH2_27294783_Chip-Seq_ESCs_Mouse2.54023733
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.50329177
15DROSHA_22980978_ChIP-Seq_HELA_Human2.49636097
16SUZ12_27294783_Chip-Seq_ESCs_Mouse2.47433019
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.43388826
18* REST_18959480_ChIP-ChIP_MESCs_Mouse2.42102192
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.40981499
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39715386
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.35956869
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.34416227
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.34103675
24TRIM28_21343339_ChIP-Seq_HEK293_Human2.30443769
25RBPJ_22232070_ChIP-Seq_NCS_Mouse2.29222484
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.21063854
27EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.19685578
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.14789749
29IKZF1_21737484_ChIP-ChIP_HCT116_Human2.11527125
30EED_16625203_ChIP-ChIP_MESCs_Mouse2.11146260
31AR_21572438_ChIP-Seq_LNCaP_Human1.94579842
32WT1_19549856_ChIP-ChIP_CCG9911_Human1.90573361
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89834772
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.87589934
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74544266
36ZNF274_21170338_ChIP-Seq_K562_Hela1.61993715
37TP53_20018659_ChIP-ChIP_R1E_Mouse1.58049085
38SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.55767473
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54882252
40SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.52714312
41RING1B_27294783_Chip-Seq_ESCs_Mouse1.50755878
42RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.48124363
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.45235543
44NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.44136494
45ISL1_27105846_Chip-Seq_CPCs_Mouse1.43935259
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.41484783
47SMAD4_21799915_ChIP-Seq_A2780_Human1.41336686
48PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.41333869
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41067711
50CLOCK_20551151_ChIP-Seq_293T_Human1.38917911
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36819464
52ZFP281_18757296_ChIP-ChIP_E14_Mouse1.35263351
53RING1B_27294783_Chip-Seq_NPCs_Mouse1.33829641
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31699543
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30980692
56HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.30565963
57DNAJC2_21179169_ChIP-ChIP_NT2_Human1.29626115
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29471657
59TAF15_26573619_Chip-Seq_HEK293_Human1.29350239
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28642879
61RNF2_27304074_Chip-Seq_NSC_Mouse1.27082392
62BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.25201621
63FOXM1_23109430_ChIP-Seq_U2OS_Human1.23455185
64* SOX2_21211035_ChIP-Seq_LN229_Gbm1.22858941
65KDM2B_26808549_Chip-Seq_K562_Human1.20526551
66AR_19668381_ChIP-Seq_PC3_Human1.19442554
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19042525
68EP300_21415370_ChIP-Seq_HL-1_Mouse1.18886715
69TP63_17297297_ChIP-ChIP_HaCaT_Human1.16712437
70P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16528718
71EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16351152
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.15230072
73* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13914246
74OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.13472508
75MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13279043
76ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.13152735
77* P300_19829295_ChIP-Seq_ESCs_Human1.13083178
78WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12090066
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11565300
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10796497
81P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10215545
82RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10178186
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09680814
84SALL1_21062744_ChIP-ChIP_HESCs_Human1.09642340
85STAT3_23295773_ChIP-Seq_U87_Human1.07518304
86AR_25329375_ChIP-Seq_VCAP_Human1.07442926
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06424124
88POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.06222694
89ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06023204
90* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04671785
91TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03989582
92SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.03738762
93* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03667734
94YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03567349
95SMAD3_21741376_ChIP-Seq_ESCs_Human1.03489381
96TBX3_20139965_ChIP-Seq_MESCs_Mouse1.02856737
97NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.02584974
98CTCF_27219007_Chip-Seq_Bcells_Human1.02419616
99TP63_19390658_ChIP-ChIP_HaCaT_Human1.02069363
100TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01410378
101NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00486964
102STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00345128
103POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99672381
104OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99658485
105ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99171518
106KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98950020
107IGF1R_20145208_ChIP-Seq_DFB_Human0.98465843
108ESR2_21235772_ChIP-Seq_MCF-7_Human0.97440982
109SOX9_26525672_Chip-Seq_HEART_Mouse0.96104883
110GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96019056
111TET1_21490601_ChIP-Seq_MESCs_Mouse0.95462801
112POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93900896
113TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93695447
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93695447
115FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.93538287
116TCF4_23295773_ChIP-Seq_U87_Human0.93267272
117SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92617745
118KDM2B_26808549_Chip-Seq_JURKAT_Human0.92373025
119RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92210094
120NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.90577893
121TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90323067
122SOX9_24532713_ChIP-Seq_HFSC_Mouse0.89730986
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89410264
124SMAD4_21741376_ChIP-Seq_HESCs_Human0.89336217
125STAT6_21828071_ChIP-Seq_BEAS2B_Human0.88274166
126TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88094591
127PIAS1_25552417_ChIP-Seq_VCAP_Human0.87861927
128CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87799602
129CDX2_19796622_ChIP-Seq_MESCs_Mouse0.87742855
130SOX3_22085726_ChIP-Seq_NPCs_Mouse0.87569502
131* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.87201351
132RUNX1_26923725_Chip-Seq_HPCs_Mouse0.85864692
133NANOG_21062744_ChIP-ChIP_HESCs_Human0.85749413
134* RUNX2_22187159_ChIP-Seq_PCA_Human0.85230701
135GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85059883
136* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84962282
137ELK4_26923725_Chip-Seq_MESODERM_Mouse0.84663724
138GATA1_26923725_Chip-Seq_HPCs_Mouse0.84106328
139* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83642501
140PRDM14_20953172_ChIP-Seq_ESCs_Human0.82714836
141ARNT_22903824_ChIP-Seq_MCF-7_Human0.81979588
142CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.80676546
143ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.80611318
144ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.80241365

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.87583231
2MP0003880_abnormal_central_pattern4.28252471
3MP0003635_abnormal_synaptic_transmissio3.89507783
4MP0004270_analgesia3.69603353
5MP0002063_abnormal_learning/memory/cond3.19379938
6MP0009745_abnormal_behavioral_response2.96418755
7MP0002064_seizures2.75790882
8MP0005423_abnormal_somatic_nervous2.72404173
9MP0003705_abnormal_hypodermis_morpholog2.71138714
10MP0001968_abnormal_touch/_nociception2.63649796
11MP0002572_abnormal_emotion/affect_behav2.59366938
12MP0002734_abnormal_mechanical_nocicepti2.55879828
13MP0009046_muscle_twitch2.55502617
14MP0001486_abnormal_startle_reflex2.40554974
15MP0002272_abnormal_nervous_system2.31949115
16MP0000778_abnormal_nervous_system2.30618805
17MP0005623_abnormal_meninges_morphology2.15994211
18MP0002822_catalepsy2.10270996
19MP0002735_abnormal_chemical_nociception2.09314898
20MP0002909_abnormal_adrenal_gland2.04173415
21MP0002184_abnormal_innervation2.03397174
22MP0002733_abnormal_thermal_nociception2.00451263
23MP0008438_abnormal_cutaneous_collagen1.97016245
24MP0009780_abnormal_chondrocyte_physiolo1.95559839
25MP0001984_abnormal_olfaction1.95094965
26MP0004811_abnormal_neuron_physiology1.95034141
27MP0002736_abnormal_nociception_after1.94497986
28MP0003122_maternal_imprinting1.93927492
29MP0001970_abnormal_pain_threshold1.89079051
30MP0006276_abnormal_autonomic_nervous1.87860869
31MP0001440_abnormal_grooming_behavior1.87028433
32MP0002249_abnormal_larynx_morphology1.85525057
33MP0002557_abnormal_social/conspecific_i1.84673300
34MP0002067_abnormal_sensory_capabilities1.83881694
35MP0000534_abnormal_ureter_morphology1.80273355
36MP0001529_abnormal_vocalization1.75707825
37MP0005645_abnormal_hypothalamus_physiol1.72760403
38MP0010030_abnormal_orbit_morphology1.71967329
39MP0000955_abnormal_spinal_cord1.71021681
40MP0008569_lethality_at_weaning1.67465987
41MP0001501_abnormal_sleep_pattern1.67305381
42MP0004858_abnormal_nervous_system1.67073396
43MP0004924_abnormal_behavior1.64337387
44MP0005386_behavior/neurological_phenoty1.64337387
45MP0005257_abnormal_intraocular_pressure1.61576851
46MP0002882_abnormal_neuron_morphology1.60592260
47MP0003329_amyloid_beta_deposits1.58343393
48MP0003942_abnormal_urinary_system1.53800887
49MP0000049_abnormal_middle_ear1.48405456
50MP0001502_abnormal_circadian_rhythm1.47097911
51MP0003879_abnormal_hair_cell1.44828040
52MP0004272_abnormal_basement_membrane1.41592881
53MP0005409_darkened_coat_color1.41165145
54MP0001299_abnormal_eye_distance/1.39611704
55MP0004885_abnormal_endolymph1.39508049
56MP0002066_abnormal_motor_capabilities/c1.38008449
57MP0003283_abnormal_digestive_organ1.37345350
58MP0009053_abnormal_anal_canal1.35024647
59MP0002152_abnormal_brain_morphology1.33998176
60MP0005646_abnormal_pituitary_gland1.33905954
61MP0003385_abnormal_body_wall1.33176423
62MP0005499_abnormal_olfactory_system1.32702865
63MP0005394_taste/olfaction_phenotype1.32702865
64MP0005551_abnormal_eye_electrophysiolog1.29997494
65MP0003787_abnormal_imprinting1.28369674
66MP0005503_abnormal_tendon_morphology1.26534126
67MP0001905_abnormal_dopamine_level1.22688347
68MP0009250_abnormal_appendicular_skeleto1.22188062
69MP0002697_abnormal_eye_size1.21662877
70MP0006072_abnormal_retinal_apoptosis1.21001208
71MP0003937_abnormal_limbs/digits/tail_de1.20751812
72MP0000013_abnormal_adipose_tissue1.20024085
73MP0008961_abnormal_basal_metabolism1.19653605
74MP0003755_abnormal_palate_morphology1.19532930
75MP0001849_ear_inflammation1.16907653
76MP0000733_abnormal_muscle_development1.16695903
77MP0000631_abnormal_neuroendocrine_gland1.16076152
78MP0002116_abnormal_craniofacial_bone1.15861097
79MP0000428_abnormal_craniofacial_morphol1.15777740
80MP0001177_atelectasis1.14632968
81MP0000579_abnormal_nail_morphology1.14575610
82MP0003935_abnormal_craniofacial_develop1.13910249
83MP0000462_abnormal_digestive_system1.13470306
84MP0000762_abnormal_tongue_morphology1.11615581
85MP0002233_abnormal_nose_morphology1.11290215
86MP0002653_abnormal_ependyma_morphology1.10203785
87MP0005410_abnormal_fertilization1.07045888
88MP0000516_abnormal_urinary_system1.06768848
89MP0005367_renal/urinary_system_phenotyp1.06768848
90MP0003115_abnormal_respiratory_system1.06184212
91MP0003119_abnormal_digestive_system1.05188889
92MP0003633_abnormal_nervous_system1.04368963
93MP0000569_abnormal_digit_pigmentation1.03479906
94MP0000751_myopathy1.02917126
95MP0005248_abnormal_Harderian_gland1.02767107
96MP0010386_abnormal_urinary_bladder1.01222375
97MP0004742_abnormal_vestibular_system1.01057047
98MP0002752_abnormal_somatic_nervous1.00782233
99MP0002081_perinatal_lethality0.99829029
100MP0002092_abnormal_eye_morphology0.99065536
101MP0002234_abnormal_pharynx_morphology0.98699308
102MP0002069_abnormal_eating/drinking_beha0.97801122
103MP0004142_abnormal_muscle_tone0.96558269
104MP0002229_neurodegeneration0.96538437
105MP0002638_abnormal_pupillary_reflex0.96073215
106MP0003861_abnormal_nervous_system0.94922067
107MP0000432_abnormal_head_morphology0.94289339
108MP0002896_abnormal_bone_mineralization0.93867231
109MP0005508_abnormal_skeleton_morphology0.93776681
110MP0005187_abnormal_penis_morphology0.93466734
111MP0004233_abnormal_muscle_weight0.93258252
112MP0003631_nervous_system_phenotype0.91842857
113MP0008789_abnormal_olfactory_epithelium0.91762220
114MP0003634_abnormal_glial_cell0.91507685
115MP0001346_abnormal_lacrimal_gland0.91387377
116MP0001958_emphysema0.90915954
117MP0003279_aneurysm0.90598666
118MP0010352_gastrointestinal_tract_polyps0.90395647
119MP0002114_abnormal_axial_skeleton0.90205443
120MP0010368_abnormal_lymphatic_system0.89186064
121MP0000566_synostosis0.89105813
122MP0002090_abnormal_vision0.87155936
123MP0003121_genomic_imprinting0.86904311
124MP0009672_abnormal_birth_weight0.86336225
125MP0001286_abnormal_eye_development0.85810783
126MP0002084_abnormal_developmental_patter0.85466234
127MP0002932_abnormal_joint_morphology0.84219195
128MP0002085_abnormal_embryonic_tissue0.83511366
129MP0005275_abnormal_skin_tensile0.82437781
130MP0003091_abnormal_cell_migration0.81854350
131MP0009703_decreased_birth_body0.80700847
132MP0004145_abnormal_muscle_electrophysio0.79939351
133MP0001963_abnormal_hearing_physiology0.78657457
134MP0005253_abnormal_eye_physiology0.78646795
135MP0002751_abnormal_autonomic_nervous0.76097075
136MP0002102_abnormal_ear_morphology0.75447799
137MP0006292_abnormal_olfactory_placode0.74098197
138MP0004085_abnormal_heartbeat0.73783062
139MP0001188_hyperpigmentation0.73073695
140MP0003698_abnormal_male_reproductive0.71730942
141MP0002837_dystrophic_cardiac_calcinosis0.70909383
142MP0003183_abnormal_peptide_metabolism0.70209045
143MP0000537_abnormal_urethra_morphology0.67679113
144MP0001485_abnormal_pinna_reflex0.67063865
145MP0003632_abnormal_nervous_system0.65131937
146MP0008872_abnormal_physiological_respon0.63728705
147MP0003137_abnormal_impulse_conducting0.62215804
148MP0008874_decreased_physiological_sensi0.61834568
149MP0001664_abnormal_digestion0.61613382
150MP0004215_abnormal_myocardial_fiber0.61117037
151MP0001943_abnormal_respiration0.60288974
152MP0000026_abnormal_inner_ear0.60174484
153MP0005535_abnormal_body_temperature0.59027652
154MP0010769_abnormal_survival0.58754029

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.75428580
2Focal motor seizures (HP:0011153)5.63966929
3Visual hallucinations (HP:0002367)5.01131832
4Focal seizures (HP:0007359)4.57267811
5Progressive cerebellar ataxia (HP:0002073)4.27796535
6Epileptic encephalopathy (HP:0200134)4.10533549
7Papilledema (HP:0001085)3.77069233
8Ankle clonus (HP:0011448)3.69191603
9Supranuclear gaze palsy (HP:0000605)3.50848994
10Atonic seizures (HP:0010819)3.26025682
11Febrile seizures (HP:0002373)3.23681264
12Absence seizures (HP:0002121)3.16840835
13Depression (HP:0000716)3.10574965
14Action tremor (HP:0002345)3.08557064
15Insidious onset (HP:0003587)2.98243797
16Termporal pattern (HP:0011008)2.98243797
17Generalized tonic-clonic seizures (HP:0002069)2.97223307
18Broad-based gait (HP:0002136)2.93417134
19Impaired vibration sensation in the lower limbs (HP:0002166)2.91454261
20Mutism (HP:0002300)2.91124935
21Limb dystonia (HP:0002451)2.90490273
22Truncal ataxia (HP:0002078)2.89314627
23Shallow orbits (HP:0000586)2.88149965
24Amblyopia (HP:0000646)2.84253596
25Dialeptic seizures (HP:0011146)2.84041784
26Poor eye contact (HP:0000817)2.82347177
27Urinary bladder sphincter dysfunction (HP:0002839)2.73855623
28Premature rupture of membranes (HP:0001788)2.69890822
29Epileptiform EEG discharges (HP:0011182)2.66654255
30Insomnia (HP:0100785)2.66263585
31Abnormal eating behavior (HP:0100738)2.64716006
32EEG with generalized epileptiform discharges (HP:0011198)2.64574635
33Pheochromocytoma (HP:0002666)2.63520180
34Megalencephaly (HP:0001355)2.61957462
35Drooling (HP:0002307)2.61815046
36Excessive salivation (HP:0003781)2.61815046
37Spastic gait (HP:0002064)2.57898371
38Protrusio acetabuli (HP:0003179)2.56852818
39Central scotoma (HP:0000603)2.56802455
40Hypsarrhythmia (HP:0002521)2.55864544
41Anxiety (HP:0000739)2.54719306
42Hyperventilation (HP:0002883)2.54518484
43Hemiparesis (HP:0001269)2.54032589
44Cerebral inclusion bodies (HP:0100314)2.51502538
45Polyphagia (HP:0002591)2.50168796
46Abnormality of the lower motor neuron (HP:0002366)2.46925539
47Urinary urgency (HP:0000012)2.44139992
48Turricephaly (HP:0000262)2.43765648
49Abnormal social behavior (HP:0012433)2.43675755
50Impaired social interactions (HP:0000735)2.43675755
51Genetic anticipation (HP:0003743)2.43581669
52Amyotrophic lateral sclerosis (HP:0007354)2.43581379
53Cortical dysplasia (HP:0002539)2.43425900
54Neuroendocrine neoplasm (HP:0100634)2.42239158
55Dysdiadochokinesis (HP:0002075)2.41675964
56Gait imbalance (HP:0002141)2.40001464
57Neurofibrillary tangles (HP:0002185)2.38261509
58Agitation (HP:0000713)2.36623690
59Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.36234030
60Dysmetria (HP:0001310)2.35518136
61Vertebral arch anomaly (HP:0008438)2.33558901
62Postural instability (HP:0002172)2.30691485
63Ulnar bowing (HP:0003031)2.30204430
64Impaired smooth pursuit (HP:0007772)2.29855885
65Lissencephaly (HP:0001339)2.29170722
66Gaze-evoked nystagmus (HP:0000640)2.26923791
67Lower limb muscle weakness (HP:0007340)2.20345494
68Abnormality of the corticospinal tract (HP:0002492)2.19581354
69Bowel diverticulosis (HP:0005222)2.15264677
70Pointed chin (HP:0000307)2.14347179
71Bladder diverticulum (HP:0000015)2.13800259
72Progressive inability to walk (HP:0002505)2.12783489
73Shoulder girdle muscle weakness (HP:0003547)2.11005879
74Torticollis (HP:0000473)2.10784748
75Abnormality of ocular smooth pursuit (HP:0000617)2.08598319
76Failure to thrive in infancy (HP:0001531)2.07870652
77Stereotypic behavior (HP:0000733)2.07585813
78Specific learning disability (HP:0001328)2.07447926
79Morphological abnormality of the middle ear (HP:0008609)2.05734327
80Vascular tortuosity (HP:0004948)2.04913975
81Focal dystonia (HP:0004373)2.04590257
82Absent speech (HP:0001344)2.03154573
83Bradykinesia (HP:0002067)2.03106576
84Hyperacusis (HP:0010780)2.02056083
85Arterial tortuosity (HP:0005116)2.01436905
86Aplasia/Hypoplasia of the brainstem (HP:0007362)2.01300082
87Hypoplasia of the brainstem (HP:0002365)2.01300082
88Dynein arm defect of respiratory motile cilia (HP:0012255)1.99751945
89Absent/shortened dynein arms (HP:0200106)1.99751945
90Neonatal short-limb short stature (HP:0008921)1.99452916
91Abnormality of dentin (HP:0010299)1.98152839
92Nephrogenic diabetes insipidus (HP:0009806)1.97868317
93Genu recurvatum (HP:0002816)1.97360226
94Neoplasm of the heart (HP:0100544)1.93678431
95Mitral regurgitation (HP:0001653)1.91654708
96Elfin facies (HP:0004428)1.91333241
97Congenital primary aphakia (HP:0007707)1.90476055
98Clonus (HP:0002169)1.90372369
99Atrophic scars (HP:0001075)1.88863302
100Fetal akinesia sequence (HP:0001989)1.88483071
101Arnold-Chiari malformation (HP:0002308)1.88159167
102Abnormality of the 4th metacarpal (HP:0010012)1.87865456
103Impaired vibratory sensation (HP:0002495)1.87786415
104Obstructive sleep apnea (HP:0002870)1.87636570
105Wide anterior fontanel (HP:0000260)1.87234399
106Ventricular fibrillation (HP:0001663)1.86443356
107Ankyloglossia (HP:0010296)1.86393369
108Broad metatarsal (HP:0001783)1.86259285
109Spinal rigidity (HP:0003306)1.84687304
110Cutaneous syndactyly (HP:0012725)1.84488854
111Short 4th metacarpal (HP:0010044)1.84120510
112Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.84120510
113Cutaneous finger syndactyly (HP:0010554)1.83956340
114Scanning speech (HP:0002168)1.82927804
115Medial flaring of the eyebrow (HP:0010747)1.82926068
116Abnormality of binocular vision (HP:0011514)1.77905476
117Diplopia (HP:0000651)1.77905476
118Neoplasm of the peripheral nervous system (HP:0100007)1.77834136
119Renal duplication (HP:0000075)1.77591757
120Ankle contracture (HP:0006466)1.77560304
121Large eyes (HP:0001090)1.74918218
122Inability to walk (HP:0002540)1.74666172
123Overriding aorta (HP:0002623)1.74017058
124Renovascular hypertension (HP:0100817)1.73656273
125High anterior hairline (HP:0009890)1.73575060
126Apathy (HP:0000741)1.73370191
127Bronchomalacia (HP:0002780)1.72173848
128Rapidly progressive (HP:0003678)1.72041628
129Aplasia involving bones of the extremities (HP:0009825)1.71642992
130Aplasia involving bones of the upper limbs (HP:0009823)1.71642992
131Aplasia of the phalanges of the hand (HP:0009802)1.71642992
132Retinal dysplasia (HP:0007973)1.71416539
133Hypoventilation (HP:0002791)1.71373149
134Intention tremor (HP:0002080)1.71179088
135Hammertoe (HP:0001765)1.70765005
136Craniofacial dystonia (HP:0012179)1.70560126
137Buphthalmos (HP:0000557)1.70550616
138Cerebral aneurysm (HP:0004944)1.70245107
139Generalized hypotonia (HP:0001290)1.69936577
140Open mouth (HP:0000194)1.68576241
141Thin ribs (HP:0000883)1.67495093
142Coronal craniosynostosis (HP:0004440)1.67030022
143Deviation of the hallux (HP:0010051)1.66373056
144Soft skin (HP:0000977)1.65973622
145Abnormality of the phalanges of the hallux (HP:0010057)1.65742673
146Precocious puberty (HP:0000826)1.65262909
147Limb-girdle muscle weakness (HP:0003325)1.65024139
148Abnormality of the distal phalanx of the thumb (HP:0009617)1.64597934
149Increased nuchal translucency (HP:0010880)1.63509481
150Urethral obstruction (HP:0000796)1.62736006
151Shawl scrotum (HP:0000049)1.62246085
152Wormian bones (HP:0002645)1.62233608
153Abnormality of the calcaneus (HP:0008364)1.61256251
154Mitral valve prolapse (HP:0001634)1.60431618
155Mild short stature (HP:0003502)1.59778491
156Hallux valgus (HP:0001822)1.59335874
157Megalocornea (HP:0000485)1.59046524
158Hyperextensible skin (HP:0000974)1.57641392
159Broad face (HP:0000283)1.57338644
160Hypoplasia of the iris (HP:0007676)1.55231205
161Abnormality of the diencephalon (HP:0010662)1.53947918
162Calcaneovalgus deformity (HP:0001848)1.52267134
163Asymmetry of the thorax (HP:0001555)1.51798855
164Broad long bones (HP:0005622)1.51558307
165Absent frontal sinuses (HP:0002688)1.51205066
166Trigonocephaly (HP:0000243)1.51066717
167Short nail (HP:0001799)1.50199134
168Congenital glaucoma (HP:0001087)1.50029900
169Overgrowth (HP:0001548)1.49230392
170Abnormality of the ischium (HP:0003174)1.47896388
171Aortic dissection (HP:0002647)1.46966085
172Obsessive-compulsive behavior (HP:0000722)1.46923223
173Broad thumb (HP:0011304)1.45830236
174Lower limb amyotrophy (HP:0007210)1.44816520
175Split foot (HP:0001839)1.44224939
176Round face (HP:0000311)1.43899182
177Spina bifida occulta (HP:0003298)1.43751279
178Narrow nasal bridge (HP:0000446)1.42916875
179Flat cornea (HP:0007720)1.42857913
180Heterochromia iridis (HP:0001100)1.42602122
181Joint laxity (HP:0001388)1.42154522
182Lower limb asymmetry (HP:0100559)1.41973340

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.33129740
2MAP3K94.16424509
3NTRK33.66387956
4EPHA43.33086437
5MAP3K42.89462232
6MINK12.73603818
7NTRK22.54835103
8PRKD32.47845694
9PAK62.33185474
10MAP2K72.24315693
11TRIB32.19540082
12DAPK22.10758898
13PDGFRA2.10382882
14KSR11.97514190
15UHMK11.87446051
16PNCK1.87381895
17KSR21.85995844
18CAMKK11.79501556
19MAPK131.76981024
20SIK21.67517543
21NTRK11.57697417
22CDK51.54158294
23MAP2K41.53546844
24LATS11.52680784
25MAP3K121.51986990
26EEF2K1.48389374
27CASK1.46127667
28PHKG21.45802285
29PHKG11.45802285
30CDK191.45005613
31TNIK1.39570539
32RIPK11.37689535
33DAPK11.36610589
34TYRO31.30309680
35MAP3K101.30146668
36PLK21.25683857
37CDK121.25026771
38TTN1.23938537
39BRD41.19755728
40GRK51.19565538
41PKN21.18099997
42PTK21.15777593
43DDR21.15035291
44MAP3K21.11916886
45PRKCG1.09305062
46CDK141.09054615
47WNK31.06373200
48CDK181.06204921
49CAMKK21.05390084
50CAMK1D1.04746235
51RIPK41.04669439
52CDK151.02139379
53PAK21.00321581
54SMG10.99045386
55ARAF0.98387701
56STK110.97755016
57DYRK1A0.94609673
58PRPF4B0.94488213
59SGK4940.93415262
60SGK2230.93415262
61ROCK20.92868003
62ICK0.92401234
63FES0.92351769
64PAK30.91888670
65TAOK10.91705349
66STK380.90884257
67CDK11A0.90303952
68MTOR0.87688142
69CSNK1G20.84414624
70DYRK20.84153405
71CDK60.83965408
72CAMK2A0.83266159
73SIK10.82897412
74MAP3K130.79753591
75CAMK10.76516967
76BRSK10.75603771
77DYRK1B0.73958920
78CAMK2B0.73357960
79MARK20.72766302
80CSNK1G10.72282864
81PRKCH0.72148007
82CSNK1A1L0.69883109
83RET0.69503282
84ROCK10.69455705
85MET0.69385602
86SIK30.68726039
87EPHA30.68583211
88LATS20.68549046
89ERBB40.66049509
90LMTK20.65665581
91CDK30.65235779
92CAMK1G0.64719766
93PDGFRB0.63551158
94PRKCZ0.62792822
95LIMK10.61843278
96MAP3K60.61680650
97NEK10.60222852
98EPHB20.59159103
99PTK2B0.58596933
100ERBB30.57877071
101AKT30.57723524
102MKNK20.57702471
103SGK10.57312236
104OXSR10.56804577
105EPHB10.56473928
106SGK20.55314215
107BCR0.54690279
108CDC42BPA0.52929638
109NEK60.52545610
110FGFR20.52362008
111DMPK0.52143814
112MKNK10.51403900
113MAP3K10.50134149
114SRPK10.49441210
115RPS6KA20.49353671
116FYN0.48584557
117CAMK2G0.48109332
118YES10.47546401
119MAPK150.47502440
120TSSK60.47160850
121WNK40.47045048
122RAF10.46691529
123CSNK1G30.46491209
124TESK10.46133940
125HIPK20.44772318
126AKT20.43958330
127ALK0.43469604
128SCYL20.42545262
129MAPK100.42271508
130RPS6KA30.41639288
131MOS0.40262474
132PRKD20.40159838
133PIM20.39618718
134NME10.39470019
135PDK10.38987303
136SGK30.38635304
137PDK40.36539931
138PDK30.36539931
139CCNB10.35810952
140CAMK2D0.35021294
141PRKCE0.33867435
142CAMK40.33744245
143PRKCB0.31594481
144FER0.31435738

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.31561379
2Synaptic vesicle cycle_Homo sapiens_hsa047213.16663992
3Olfactory transduction_Homo sapiens_hsa047402.68785176
4Circadian entrainment_Homo sapiens_hsa047132.67593396
5GABAergic synapse_Homo sapiens_hsa047272.58700001
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.53819089
7Long-term potentiation_Homo sapiens_hsa047202.50992727
8Morphine addiction_Homo sapiens_hsa050322.45862119
9Amphetamine addiction_Homo sapiens_hsa050312.43977822
10Glutamatergic synapse_Homo sapiens_hsa047242.42316839
11Insulin secretion_Homo sapiens_hsa049112.29711063
12Dopaminergic synapse_Homo sapiens_hsa047282.28714838
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.25672713
14Cholinergic synapse_Homo sapiens_hsa047252.01015411
15Cocaine addiction_Homo sapiens_hsa050301.88470273
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.83408985
17Salivary secretion_Homo sapiens_hsa049701.83307636
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.74385838
19Gastric acid secretion_Homo sapiens_hsa049711.72443672
20Taste transduction_Homo sapiens_hsa047421.70048317
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.69853864
22Renin secretion_Homo sapiens_hsa049241.68539339
23Oxytocin signaling pathway_Homo sapiens_hsa049211.60708771
24Basal cell carcinoma_Homo sapiens_hsa052171.60322116
25Serotonergic synapse_Homo sapiens_hsa047261.58711047
26Long-term depression_Homo sapiens_hsa047301.52873507
27Adherens junction_Homo sapiens_hsa045201.49709959
28Vitamin B6 metabolism_Homo sapiens_hsa007501.48020619
29Gap junction_Homo sapiens_hsa045401.45279407
30Axon guidance_Homo sapiens_hsa043601.42769788
31Calcium signaling pathway_Homo sapiens_hsa040201.38994721
32GnRH signaling pathway_Homo sapiens_hsa049121.38927340
33Phototransduction_Homo sapiens_hsa047441.37795974
34Type II diabetes mellitus_Homo sapiens_hsa049301.34401720
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.30248400
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28203735
37Notch signaling pathway_Homo sapiens_hsa043301.27237694
38Estrogen signaling pathway_Homo sapiens_hsa049151.24236423
39Collecting duct acid secretion_Homo sapiens_hsa049661.22117034
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21299100
41cAMP signaling pathway_Homo sapiens_hsa040241.19910977
42Glioma_Homo sapiens_hsa052141.17391727
43Focal adhesion_Homo sapiens_hsa045101.17364602
44Melanogenesis_Homo sapiens_hsa049161.14949862
45MicroRNAs in cancer_Homo sapiens_hsa052061.14684122
46ECM-receptor interaction_Homo sapiens_hsa045121.14391656
47Oocyte meiosis_Homo sapiens_hsa041141.12922660
48Chronic myeloid leukemia_Homo sapiens_hsa052201.12792301
49Tight junction_Homo sapiens_hsa045301.12650207
50cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11106033
51ErbB signaling pathway_Homo sapiens_hsa040121.07478299
52Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07187589
53Dorso-ventral axis formation_Homo sapiens_hsa043201.05590456
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99519846
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98909148
56Vibrio cholerae infection_Homo sapiens_hsa051100.98721358
57Cardiac muscle contraction_Homo sapiens_hsa042600.97332345
58Lysine degradation_Homo sapiens_hsa003100.95263035
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93748286
60Proteoglycans in cancer_Homo sapiens_hsa052050.92250772
61AMPK signaling pathway_Homo sapiens_hsa041520.91002493
62Alcoholism_Homo sapiens_hsa050340.90412740
63Melanoma_Homo sapiens_hsa052180.89305450
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.88183302
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87491109
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.85559603
67Bladder cancer_Homo sapiens_hsa052190.85171920
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85099412
69Thyroid cancer_Homo sapiens_hsa052160.83630978
70TGF-beta signaling pathway_Homo sapiens_hsa043500.81653217
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.81322889
72Prostate cancer_Homo sapiens_hsa052150.80110182
73Glucagon signaling pathway_Homo sapiens_hsa049220.77470652
74mRNA surveillance pathway_Homo sapiens_hsa030150.77285545
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77108285
76Choline metabolism in cancer_Homo sapiens_hsa052310.75181300
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74965776
78Pancreatic secretion_Homo sapiens_hsa049720.74786857
79VEGF signaling pathway_Homo sapiens_hsa043700.72713306
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72263657
81MAPK signaling pathway_Homo sapiens_hsa040100.72181751
82Protein digestion and absorption_Homo sapiens_hsa049740.71898243
83Pancreatic cancer_Homo sapiens_hsa052120.71572483
84Pathways in cancer_Homo sapiens_hsa052000.71082968
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70643598
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69928264
87Thyroid hormone synthesis_Homo sapiens_hsa049180.69872539
88Endometrial cancer_Homo sapiens_hsa052130.69823400
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69574997
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67681682
91Wnt signaling pathway_Homo sapiens_hsa043100.66534170
92Dilated cardiomyopathy_Homo sapiens_hsa054140.66447665
93mTOR signaling pathway_Homo sapiens_hsa041500.66057538
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65768366
95Colorectal cancer_Homo sapiens_hsa052100.65563742
96Renal cell carcinoma_Homo sapiens_hsa052110.64026428
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63149833
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62788166
99Endocytosis_Homo sapiens_hsa041440.61741267
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61423048
101Non-small cell lung cancer_Homo sapiens_hsa052230.61016144
102Ras signaling pathway_Homo sapiens_hsa040140.60458607
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59607064
104PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57945674
105Type I diabetes mellitus_Homo sapiens_hsa049400.57874033
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57279355
107Amoebiasis_Homo sapiens_hsa051460.56843368
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56707391
109Insulin signaling pathway_Homo sapiens_hsa049100.54614978
110Circadian rhythm_Homo sapiens_hsa047100.54026489
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52019651
112Rap1 signaling pathway_Homo sapiens_hsa040150.51176536
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.50451334
114Hedgehog signaling pathway_Homo sapiens_hsa043400.48746101
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48572109
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46658760
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44256825
118Inositol phosphate metabolism_Homo sapiens_hsa005620.44152432
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42923773
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42468096
121Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39972818
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36964392
123Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34212143
124Prion diseases_Homo sapiens_hsa050200.34169696
125Hippo signaling pathway_Homo sapiens_hsa043900.32506774
126Alzheimers disease_Homo sapiens_hsa050100.32158517
127Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31432768
128Chemokine signaling pathway_Homo sapiens_hsa040620.31009257
129Prolactin signaling pathway_Homo sapiens_hsa049170.30102950
130Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28064645
131Central carbon metabolism in cancer_Homo sapiens_hsa052300.26749318

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