LECT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of extracellular matrix organization (GO:1903055)9.11478882
2collagen fibril organization (GO:0030199)7.36565256
3embryonic skeletal joint morphogenesis (GO:0060272)7.08627020
4sphingomyelin metabolic process (GO:0006684)6.41250837
5regulation of extracellular matrix disassembly (GO:0010715)6.20805645
6establishment of integrated proviral latency (GO:0075713)6.15454331
7nucleotide-sugar biosynthetic process (GO:0009226)5.89677081
8chondroitin sulfate biosynthetic process (GO:0030206)5.78986227
9* cartilage development (GO:0051216)5.77087515
10regulation of extracellular matrix organization (GO:1903053)5.56707887
11protein retention in ER lumen (GO:0006621)5.47498906
12chondrocyte differentiation (GO:0002062)5.44174155
13negative regulation of gluconeogenesis (GO:0045721)5.43294812
14cellular glucuronidation (GO:0052695)5.41544731
15regulation of posttranscriptional gene silencing (GO:0060147)5.37846705
16regulation of gene silencing by miRNA (GO:0060964)5.37846705
17regulation of gene silencing by RNA (GO:0060966)5.37846705
18keratan sulfate biosynthetic process (GO:0018146)5.33828690
19positive regulation of chondrocyte differentiation (GO:0032332)5.28253674
20replacement ossification (GO:0036075)5.24624916
21endochondral ossification (GO:0001958)5.24624916
22* proteoglycan metabolic process (GO:0006029)5.24575406
23iron ion import (GO:0097286)5.10456478
24regulation of plasminogen activation (GO:0010755)5.09480122
25lipopolysaccharide biosynthetic process (GO:0009103)5.04472395
26maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.03847566
27L-serine metabolic process (GO:0006563)5.02804229
28endocardial cushion morphogenesis (GO:0003203)4.94582029
29chromatin remodeling at centromere (GO:0031055)4.93973049
30collagen catabolic process (GO:0030574)4.89017822
31glucuronate metabolic process (GO:0019585)4.87871694
32uronic acid metabolic process (GO:0006063)4.87871694
33IMP biosynthetic process (GO:0006188)4.82023043
34CENP-A containing nucleosome assembly (GO:0034080)4.74257632
35pre-miRNA processing (GO:0031054)4.71098984
36establishment of viral latency (GO:0019043)4.66768013
37collagen metabolic process (GO:0032963)4.60734641
38* skeletal system development (GO:0001501)4.55849886
39cellular response to BMP stimulus (GO:0071773)4.54098302
40response to BMP (GO:0071772)4.54098302
41multicellular organismal catabolic process (GO:0044243)4.47063354
42regulation of helicase activity (GO:0051095)4.42220651
43positive regulation of cartilage development (GO:0061036)4.39029435
44IMP metabolic process (GO:0046040)4.34418134
45peptidyl-proline hydroxylation (GO:0019511)4.32182055
46keratan sulfate metabolic process (GO:0042339)4.30249153
47multicellular organismal macromolecule metabolic process (GO:0044259)4.29620632
48regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.28708702
49regulation of mitotic spindle checkpoint (GO:1903504)4.28708702
50protein complex localization (GO:0031503)4.27235794
51lipopolysaccharide metabolic process (GO:0008653)4.26040513
52histone exchange (GO:0043486)4.23141412
53protein localization to kinetochore (GO:0034501)4.22774548
54purine nucleobase biosynthetic process (GO:0009113)4.20199756
55negative regulation of telomerase activity (GO:0051974)4.20136805
56DNA strand elongation involved in DNA replication (GO:0006271)4.17338874
57negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)4.13960474
58negative regulation of mitotic sister chromatid segregation (GO:0033048)4.13960474
59negative regulation of mitotic sister chromatid separation (GO:2000816)4.13960474
60negative regulation of sister chromatid segregation (GO:0033046)4.13960474
61negative regulation of mitotic metaphase/anaphase transition (GO:0045841)4.13960474
62hypotonic response (GO:0006971)4.09761594
63multicellular organismal metabolic process (GO:0044236)4.09736901
64otic vesicle formation (GO:0030916)4.09395610
65DNA replication checkpoint (GO:0000076)4.08632452
66DNA replication-independent nucleosome assembly (GO:0006336)4.06772829
67DNA replication-independent nucleosome organization (GO:0034724)4.06772829
68negative regulation of chromosome segregation (GO:0051985)4.06265161
69heterochromatin organization (GO:0070828)3.99905045
70regulation of type B pancreatic cell apoptotic process (GO:2000674)3.95084470
71connective tissue development (GO:0061448)3.93166682
72extracellular matrix disassembly (GO:0022617)3.92832801
73DNA strand elongation (GO:0022616)3.92781239
74detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.92077891
75short-term memory (GO:0007614)3.90979599
76mitotic metaphase plate congression (GO:0007080)3.90288786
77glycosaminoglycan biosynthetic process (GO:0006024)3.90074838
78negative regulation of chemokine production (GO:0032682)3.90065007
79nucleobase biosynthetic process (GO:0046112)3.89251667
80positive regulation of male gonad development (GO:2000020)3.85419826
81mesenchyme morphogenesis (GO:0072132)3.85074298
82aminoglycan biosynthetic process (GO:0006023)3.84427450
83UDP-N-acetylglucosamine metabolic process (GO:0006047)3.83560107
84COPII vesicle coating (GO:0048208)3.80752317
85negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.74661134
86heart valve formation (GO:0003188)3.73687302
87negative regulation of DNA-dependent DNA replication (GO:2000104)3.73677684
88chondroitin sulfate metabolic process (GO:0030204)3.68580520
89mitotic spindle checkpoint (GO:0071174)3.64929136
90spindle checkpoint (GO:0031577)3.64713732
91regulation of telomere maintenance via telomerase (GO:0032210)3.61883831
92telomere maintenance via telomerase (GO:0007004)3.60908863
93myelin assembly (GO:0032288)3.60085936
94regulation of histone H3-K9 methylation (GO:0051570)3.59189077
95nephron tubule formation (GO:0072079)3.58842671
96regulation of male gonad development (GO:2000018)3.58576179
97paraxial mesoderm development (GO:0048339)3.57954135
98chaperone-mediated protein transport (GO:0072321)3.57158461
99regulation of chondrocyte differentiation (GO:0032330)3.56656294
100regulation of nuclear cell cycle DNA replication (GO:0033262)3.55497375
101L-alpha-amino acid transmembrane transport (GO:1902475)3.55212080
102regulation of mitotic metaphase/anaphase transition (GO:0030071)3.55034343
103regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.55034343
104regulation of integrin-mediated signaling pathway (GO:2001044)3.54711637
105regulation of cell fate specification (GO:0042659)3.54111914
106mitotic spindle assembly checkpoint (GO:0007094)3.53785585
107positive regulation of SMAD protein import into nucleus (GO:0060391)3.53519472
108eye photoreceptor cell differentiation (GO:0001754)3.53510091
109photoreceptor cell differentiation (GO:0046530)3.53510091
110negative regulation of NF-kappaB import into nucleus (GO:0042347)3.53283289
111negative regulation of smooth muscle cell differentiation (GO:0051151)3.52048810
112regulation of mitotic sister chromatid separation (GO:0010965)3.49755998
113regulation of mitotic sister chromatid segregation (GO:0033047)3.49755998
114regulation of sister chromatid segregation (GO:0033045)3.49755998
115response to gravity (GO:0009629)3.48955274
116nuclear pore complex assembly (GO:0051292)3.47129448
117glycosaminoglycan catabolic process (GO:0006027)3.45771704
118spindle assembly checkpoint (GO:0071173)3.44232257
119telomere maintenance via semi-conservative replication (GO:0032201)3.44046547
120somatic hypermutation of immunoglobulin genes (GO:0016446)3.43513750
121somatic diversification of immune receptors via somatic mutation (GO:0002566)3.43513750
122DNA damage response, detection of DNA damage (GO:0042769)3.43386249
123negative regulation of translation, ncRNA-mediated (GO:0040033)3.43109888
124regulation of translation, ncRNA-mediated (GO:0045974)3.43109888
125negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.43109888
126ribosome assembly (GO:0042255)3.42586165
127serine family amino acid biosynthetic process (GO:0009070)3.42403066
128regulation of response to osmotic stress (GO:0047484)3.41842033
129negative regulation of mitosis (GO:0045839)3.40550391
130DNA replication-dependent nucleosome assembly (GO:0006335)3.39334722
131DNA replication-dependent nucleosome organization (GO:0034723)3.39334722
132nucleotide-sugar metabolic process (GO:0009225)3.38246616
133proteasome assembly (GO:0043248)3.35255079
134* glycoprotein metabolic process (GO:0009100)3.34299640
135DNA double-strand break processing (GO:0000729)3.33158635
136sulfur compound catabolic process (GO:0044273)3.32164624
137regulation of cell maturation (GO:1903429)3.32086741
138DNA ligation (GO:0006266)3.31473869
139negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.31411634
140protein hydroxylation (GO:0018126)3.30516580
141regulation of cartilage development (GO:0061035)3.29484944
142cellular protein complex localization (GO:0034629)3.29181778
143metaphase plate congression (GO:0051310)3.28137837
144endodermal cell differentiation (GO:0035987)3.27154118
145DNA unwinding involved in DNA replication (GO:0006268)3.26456364
146regulation of chromosome segregation (GO:0051983)3.26430119
147negative regulation of cartilage development (GO:0061037)3.25022547
148aminoglycan catabolic process (GO:0006026)3.24917502
149single strand break repair (GO:0000012)3.24096206
150establishment of protein localization to mitochondrial membrane (GO:0090151)3.22684457
151ossification (GO:0001503)3.22514815
152RNA-dependent DNA replication (GO:0006278)3.21965511
153nuclear pore organization (GO:0006999)3.21732475
154ATP-dependent chromatin remodeling (GO:0043044)3.18674420
155regulation of metalloenzyme activity (GO:0048552)3.17243282
156response to X-ray (GO:0010165)3.17098190
157termination of RNA polymerase III transcription (GO:0006386)3.16779919
158transcription elongation from RNA polymerase III promoter (GO:0006385)3.16779919
159double-strand break repair via nonhomologous end joining (GO:0006303)3.16488319
160non-recombinational repair (GO:0000726)3.16488319
161extracellular matrix organization (GO:0030198)3.15477041
162extracellular structure organization (GO:0043062)3.14651960
163histone arginine methylation (GO:0034969)3.13527844
164lysine metabolic process (GO:0006553)3.13394616
165lysine catabolic process (GO:0006554)3.13394616
166proteoglycan biosynthetic process (GO:0030166)3.12944773
167regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.11836647
168protein localization to chromosome, centromeric region (GO:0071459)3.10263612
169Golgi transport vesicle coating (GO:0048200)3.09237615
170COPI coating of Golgi vesicle (GO:0048205)3.09237615
171spliceosomal snRNP assembly (GO:0000387)3.07820375
172telomere maintenance via telomere lengthening (GO:0010833)3.03809840
173regulation of bone mineralization (GO:0030500)3.02544160
174negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.02348515
175negative regulation of ligase activity (GO:0051352)3.02348515
176negative regulation of chondrocyte differentiation (GO:0032331)3.01753547
177negative regulation of nuclear division (GO:0051784)3.01175571
178embryonic viscerocranium morphogenesis (GO:0048703)2.99738343
179negative regulation of DNA recombination (GO:0045910)2.98962473
180mucopolysaccharide metabolic process (GO:1903510)2.98780951
181maintenance of gastrointestinal epithelium (GO:0030277)2.96438865
182telomere maintenance via recombination (GO:0000722)2.96246834
183hyperosmotic salinity response (GO:0042538)2.95418867
184folic acid-containing compound biosynthetic process (GO:0009396)2.95313798
185negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.94617426
186ribosomal small subunit assembly (GO:0000028)2.94349381
187mitotic G2/M transition checkpoint (GO:0044818)2.94123667
188chondrocyte proliferation (GO:0035988)2.92469548
189DNA replication initiation (GO:0006270)2.91338036
190positive regulation of hormone biosynthetic process (GO:0046886)2.83261679
191regulation of mesenchymal cell apoptotic process (GO:2001053)2.82309981
192negative regulation of glycogen biosynthetic process (GO:0045719)2.79522979
193positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.78214968
194cartilage development involved in endochondral bone morphogenesis (GO:0060351)13.9031784
195cell aggregation (GO:0098743)12.6085772
196cartilage condensation (GO:0001502)12.6085772
197chondrocyte development (GO:0002063)12.2935801
198keratan sulfate catabolic process (GO:0042340)10.6405480
199notochord development (GO:0030903)10.3160866
200limb bud formation (GO:0060174)10.2442731

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.98134042
2TRIM28_21343339_ChIP-Seq_HEK293_Human7.95700475
3AR_21572438_ChIP-Seq_LNCaP_Human6.07180837
4GATA1_22025678_ChIP-Seq_K562_Human4.22522010
5MYC_18555785_ChIP-Seq_MESCs_Mouse4.15858809
6SMAD_19615063_ChIP-ChIP_OVARY_Human3.95084377
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.90215518
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.80855360
9TP63_17297297_ChIP-ChIP_HaCaT_Human3.78634268
10FOXM1_23109430_ChIP-Seq_U2OS_Human3.13848482
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.11449008
12EST1_17652178_ChIP-ChIP_JURKAT_Human3.01766068
13MYC_19079543_ChIP-ChIP_MESCs_Mouse3.00039594
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.92127644
15KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.90112403
16KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.90112403
17KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.90112403
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.90014266
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.89546541
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.84081152
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.77598874
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.76953205
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.65718282
24PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.58055015
25CREB1_15753290_ChIP-ChIP_HEK293T_Human2.47164018
26POU5F1_16153702_ChIP-ChIP_HESCs_Human2.37537793
27ESR2_21235772_ChIP-Seq_MCF-7_Human2.36734792
28MYC_18358816_ChIP-ChIP_MESCs_Mouse2.35943167
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.34532421
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.25862427
31POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.25025040
32KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.17589167
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.16646155
34NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15142512
35* NANOG_16153702_ChIP-ChIP_HESCs_Human2.14442005
36SOX2_16153702_ChIP-ChIP_HESCs_Human2.13588799
37CJUN_26792858_Chip-Seq_BT549_Human2.11246004
38ETS1_20019798_ChIP-Seq_JURKAT_Human2.06466617
39JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.06010695
40E2F1_21310950_ChIP-Seq_MCF-7_Human2.05988792
41E2F1_18555785_ChIP-Seq_MESCs_Mouse2.05192845
42FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.00028332
43* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.98410059
44AR_21909140_ChIP-Seq_LNCAP_Human1.97828341
45SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.97547659
46HIF1A_21447827_ChIP-Seq_MCF-7_Human1.97239976
47RARG_19884340_ChIP-ChIP_MEFs_Mouse1.96955774
48EED_16625203_ChIP-ChIP_MESCs_Mouse1.96073465
49ELK1_19687146_ChIP-ChIP_HELA_Human1.95309193
50EZH2_27304074_Chip-Seq_ESCs_Mouse1.95062309
51MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.87126989
52TCF3_18692474_ChIP-Seq_MEFs_Mouse1.87082316
53SOX2_18555785_ChIP-Seq_MESCs_Mouse1.86569041
54HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85376604
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.84671179
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.84422320
57TP53_18474530_ChIP-ChIP_U2OS_Human1.81718171
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.80767984
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80625663
60MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79591021
61FOXP3_21729870_ChIP-Seq_TREG_Human1.73335031
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.67076571
63TTF2_22483619_ChIP-Seq_HELA_Human1.66945273
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.65830946
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64274517
66XRN2_22483619_ChIP-Seq_HELA_Human1.61451314
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.58197014
68FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.56848107
69MYC_18940864_ChIP-ChIP_HL60_Human1.54882410
70HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.52475394
71VDR_24787735_ChIP-Seq_THP-1_Human1.50619788
72JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.48611960
73WT1_19549856_ChIP-ChIP_CCG9911_Human1.48224020
74RXR_22108803_ChIP-Seq_LS180_Human1.47392228
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.46461234
76NRF2_20460467_ChIP-Seq_MEFs_Mouse1.46461234
77SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.44985568
78CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.44950523
79SOX2_20726797_ChIP-Seq_SW620_Human1.44582421
80YY1_21170310_ChIP-Seq_MESCs_Mouse1.43630701
81NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.43071701
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42621518
83JARID2_20064375_ChIP-Seq_MESCs_Mouse1.41309290
84RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.40872791
85TCF3_18692474_ChIP-Seq_MESCs_Mouse1.40789593
86VDR_23849224_ChIP-Seq_CD4+_Human1.40626668
87NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.40241695
88FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39269442
89ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37530013
90TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37417288
91SALL1_21062744_ChIP-ChIP_HESCs_Human1.36834836
92SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.36418392
93PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35712851
94SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.35461886
95FOXM1_26456572_ChIP-Seq_MCF-7_Human1.34949994
96ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.33460928
97SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.32887493
98SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.32329778
99HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32207773
100DCP1A_22483619_ChIP-Seq_HELA_Human1.31095068
101ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30975984
102* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.30903870
103EZH2_18974828_ChIP-Seq_MESCs_Mouse1.28652968
104RNF2_18974828_ChIP-Seq_MESCs_Mouse1.28652968
105ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.27990499
106DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.27806561
107HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26963333
108SALL4_18804426_ChIP-ChIP_XEN_Mouse1.26833627
109JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26795229
110ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.25363040
111GATA3_24758297_ChIP-Seq_MCF-7_Human1.25329490
112JARID2_20075857_ChIP-Seq_MESCs_Mouse1.24197732
113OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24083234
114EZH2_27294783_Chip-Seq_NPCs_Mouse1.23162406
115SMAD3_21741376_ChIP-Seq_EPCs_Human1.23082108
116PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21453011
117TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.21137907
118SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20492747
119ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.20290488
120PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19923943
121NFE2_27457419_Chip-Seq_LIVER_Mouse1.19338962
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19230405
123POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19230405
124EWS_26573619_Chip-Seq_HEK293_Human1.18527316
125PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17865079
126UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15950229
127ELK1_22589737_ChIP-Seq_MCF10A_Human1.13894073
128NANOG_18555785_Chip-Seq_ESCs_Mouse1.13786177
129SOX2_18692474_ChIP-Seq_MEFs_Mouse1.13335703
130BRD4_25478319_ChIP-Seq_HGPS_Human1.12291422
131CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11852467
132GABP_19822575_ChIP-Seq_HepG2_Human1.10978706
133SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.08988142
134PIAS1_25552417_ChIP-Seq_VCAP_Human1.06526299
135CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06099002
136RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05491280
137P53_22387025_ChIP-Seq_ESCs_Mouse1.04624339
138BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04575958
139SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04167746
140GATA1_26923725_Chip-Seq_HPCs_Mouse1.04000216
141GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.03960921
142KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03912276
143PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02725874
144SRF_21415370_ChIP-Seq_HL-1_Mouse1.02448885
145TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02404685
146MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.02396487
147* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.02029831
148TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01318414
149PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00635084
150MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99145800
151KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98676555
152FUS_26573619_Chip-Seq_HEK293_Human0.98282837
153POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.98168783
154NANOG_21062744_ChIP-ChIP_HESCs_Human0.97131938
155NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97108161
156ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.96304382
157CDX2_20551321_ChIP-Seq_CACO-2_Human0.95389332
158E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95134323
159SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.94317284
160SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.94317284
161SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.94277620
162* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94074413
163NANOG_18692474_ChIP-Seq_MEFs_Mouse0.94042583
164E2F1_18555785_Chip-Seq_ESCs_Mouse0.93137335
165SOX2_18555785_Chip-Seq_ESCs_Mouse0.92913731
166TCF4_22108803_ChIP-Seq_LS180_Human0.92858247
167MTF2_20144788_ChIP-Seq_MESCs_Mouse0.92816044
168ELF5_23300383_ChIP-Seq_T47D_Human0.92280947
169CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91878870
170RBPJ_22232070_ChIP-Seq_NCS_Mouse0.91532281
171SOX2_18692474_ChIP-Seq_MESCs_Mouse0.91197427
172CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90652065
173CBX2_27304074_Chip-Seq_ESCs_Mouse0.90464260
174SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.89607455
175NFIB_24661679_ChIP-Seq_LUNG_Mouse0.89471063
176NOTCH1_21737748_ChIP-Seq_TLL_Human0.88992951
177STAT3_18555785_Chip-Seq_ESCs_Mouse0.88798255
178CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88699337
179IRF1_19129219_ChIP-ChIP_H3396_Human0.87992803
180ER_23166858_ChIP-Seq_MCF-7_Human0.87409706
181SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.86219564
182SOX17_20123909_ChIP-Seq_XEN_Mouse0.86166284
183NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.85914106
184KLF4_18555785_ChIP-Seq_MESCs_Mouse0.85896923
185OCT4_18692474_ChIP-Seq_MEFs_Mouse0.85811686
186P300_18555785_Chip-Seq_ESCs_Mouse0.85748013
187GBX2_23144817_ChIP-Seq_PC3_Human0.85591952
188HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.85519968
189RNF2_27304074_Chip-Seq_ESCs_Mouse0.84428244
190CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.83608354
191CRX_20693478_ChIP-Seq_RETINA_Mouse0.83090982
192POU3F2_20337985_ChIP-ChIP_501MEL_Human0.82984257
193TP63_23658742_ChIP-Seq_EP156T_Human0.82633428
194EGR1_19032775_ChIP-ChIP_M12_Human0.82076992
195P300_19829295_ChIP-Seq_ESCs_Human0.81463723
196VDR_22108803_ChIP-Seq_LS180_Human0.80847530

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004134_abnormal_chest_morphology6.48434069
2MP0002282_abnormal_trachea_morphology6.33871159
3MP0002933_joint_inflammation6.02757778
4MP0002254_reproductive_system_inflammat4.87828576
5MP0003646_muscle_fatigue4.28935437
6MP0005503_abnormal_tendon_morphology4.27903710
7MP0000163_abnormal_cartilage_morphology4.21236808
8MP0003693_abnormal_embryo_hatching4.16123910
9MP0009250_abnormal_appendicular_skeleto4.00948212
10MP0004957_abnormal_blastocyst_morpholog3.84164405
11MP0010094_abnormal_chromosome_stability3.54045438
12MP0003111_abnormal_nucleus_morphology3.50788323
13MP0008877_abnormal_DNA_methylation3.39182336
14MP0002115_abnormal_skeleton_extremities3.37938267
15MP0008058_abnormal_DNA_repair3.37347927
16MP0006292_abnormal_olfactory_placode3.32305951
17MP0009780_abnormal_chondrocyte_physiolo3.25511028
18MP0001188_hyperpigmentation3.03540943
19MP0002089_abnormal_postnatal_growth/wei2.90781347
20MP0000762_abnormal_tongue_morphology2.88430319
21MP0008057_abnormal_DNA_replication2.85357755
22MP0002896_abnormal_bone_mineralization2.81119892
23MP0008932_abnormal_embryonic_tissue2.75090817
24MP0009672_abnormal_birth_weight2.74542295
25MP0001299_abnormal_eye_distance/2.70666484
26* MP0002113_abnormal_skeleton_development2.69579072
27MP0003890_abnormal_embryonic-extraembry2.63945627
28MP0003077_abnormal_cell_cycle2.62928254
29MP0001270_distended_abdomen2.51640545
30MP0003718_maternal_effect2.46483281
31MP0002909_abnormal_adrenal_gland2.46412139
32MP0008007_abnormal_cellular_replicative2.32966407
33MP0005508_abnormal_skeleton_morphology2.32118641
34MP0003567_abnormal_fetal_cardiomyocyte2.30933351
35MP0001293_anophthalmia2.26110035
36MP0003123_paternal_imprinting2.24790894
37MP0002109_abnormal_limb_morphology2.20709433
38MP0003136_yellow_coat_color2.15695732
39* MP0005390_skeleton_phenotype2.04243623
40MP0003195_calcinosis1.93377075
41* MP0001533_abnormal_skeleton_physiology1.88558848
42MP0003283_abnormal_digestive_organ1.87433546
43MP0001730_embryonic_growth_arrest1.87280852
44MP0003755_abnormal_palate_morphology1.86734026
45MP0000049_abnormal_middle_ear1.79565680
46MP0001542_abnormal_bone_strength1.78650343
47MP0008004_abnormal_stomach_pH1.74499788
48MP0002249_abnormal_larynx_morphology1.74374938
49MP0009384_cardiac_valve_regurgitation1.73280462
50* MP0003795_abnormal_bone_structure1.72703716
51MP0000751_myopathy1.69771662
52MP0000579_abnormal_nail_morphology1.67948390
53MP0003656_abnormal_erythrocyte_physiolo1.67812276
54MP0002116_abnormal_craniofacial_bone1.65760676
55MP0000350_abnormal_cell_proliferation1.58820039
56MP0004133_heterotaxia1.48617826
57MP0010352_gastrointestinal_tract_polyps1.47759348
58MP0002085_abnormal_embryonic_tissue1.47497619
59MP0002697_abnormal_eye_size1.44484604
60MP0009703_decreased_birth_body1.42101667
61MP0008438_abnormal_cutaneous_collagen1.41990135
62MP0002233_abnormal_nose_morphology1.39953802
63MP0003436_decreased_susceptibility_to1.38949581
64MP0001672_abnormal_embryogenesis/_devel1.34458650
65MP0005380_embryogenesis_phenotype1.34458650
66MP0002084_abnormal_developmental_patter1.32771514
67MP0003705_abnormal_hypodermis_morpholog1.32641076
68MP0002108_abnormal_muscle_morphology1.32275390
69MP0000432_abnormal_head_morphology1.31360924
70MP0002938_white_spotting1.31088064
71MP0002796_impaired_skin_barrier1.25021572
72MP0003279_aneurysm1.24460629
73MP0001697_abnormal_embryo_size1.23635990
74MP0002111_abnormal_tail_morphology1.23434021
75MP0005275_abnormal_skin_tensile1.22303558
76MP0006035_abnormal_mitochondrial_morpho1.20846668
77MP0004272_abnormal_basement_membrane1.20590272
78MP0002163_abnormal_gland_morphology1.20154719
79MP0003878_abnormal_ear_physiology1.17501555
80MP0005377_hearing/vestibular/ear_phenot1.17501555
81MP0003937_abnormal_limbs/digits/tail_de1.16973457
82MP0002080_prenatal_lethality1.16825460
83MP0001529_abnormal_vocalization1.14643406
84MP0001663_abnormal_digestive_system1.13125748
85MP0005023_abnormal_wound_healing1.12712192
86MP0003984_embryonic_growth_retardation1.11480106
87MP0009379_abnormal_foot_pigmentation1.11347164
88MP0005381_digestive/alimentary_phenotyp1.11143098
89MP0001485_abnormal_pinna_reflex1.10790294
90MP0003566_abnormal_cell_adhesion1.09105105
91MP0002114_abnormal_axial_skeleton1.09063030
92MP0002088_abnormal_embryonic_growth/wei1.08432584
93MP0003935_abnormal_craniofacial_develop1.05507424
94MP0009697_abnormal_copulation1.04749284
95MP0002736_abnormal_nociception_after1.04029154
96MP0010307_abnormal_tumor_latency1.04016370
97MP0003950_abnormal_plasma_membrane1.02138722
98MP0010030_abnormal_orbit_morphology1.01143065
99MP0001963_abnormal_hearing_physiology1.00229401
100MP0003787_abnormal_imprinting0.99940377
101MP0006072_abnormal_retinal_apoptosis0.99778654
102MP0003186_abnormal_redox_activity0.99620690
103MP0000343_altered_response_to0.98877289
104MP0004197_abnormal_fetal_growth/weight/0.96485841
105MP0004484_altered_response_of0.92264678
106MP0000313_abnormal_cell_death0.92248666
107MP0003786_premature_aging0.91055550
108MP0002751_abnormal_autonomic_nervous0.88927838
109MP0003091_abnormal_cell_migration0.86198630
110MP0002090_abnormal_vision0.84224526
111MP0002877_abnormal_melanocyte_morpholog0.82552266
112MP0002277_abnormal_respiratory_mucosa0.82061916
113MP0001958_emphysema0.80772661
114MP0004084_abnormal_cardiac_muscle0.80496946
115MP0002735_abnormal_chemical_nociception0.79880285
116MP0005646_abnormal_pituitary_gland0.79673730
117MP0001145_abnormal_male_reproductive0.79456502
118MP0002210_abnormal_sex_determination0.78183160
119MP0003861_abnormal_nervous_system0.76788808
120MP0002086_abnormal_extraembryonic_tissu0.75271036
121MP0004147_increased_porphyrin_level0.73303779
122MP0008789_abnormal_olfactory_epithelium0.73079545
123MP0001849_ear_inflammation0.72787061
124MP0005248_abnormal_Harderian_gland0.72782438
125MP0002396_abnormal_hematopoietic_system0.70619748
126MP0002932_abnormal_joint_morphology0.68944436
127MP0001929_abnormal_gametogenesis0.68901222
128MP0005395_other_phenotype0.68810412
129MP0003938_abnormal_ear_development0.68454138
130MP0005164_abnormal_response_to0.68215547
131MP0003315_abnormal_perineum_morphology0.67154343
132MP0003122_maternal_imprinting0.66634213
133MP0003121_genomic_imprinting0.66008170
134MP0000428_abnormal_craniofacial_morphol0.65593410
135MP0000537_abnormal_urethra_morphology0.64418025
136MP0000653_abnormal_sex_gland0.63826326
137MP0005367_renal/urinary_system_phenotyp0.62648412
138MP0000516_abnormal_urinary_system0.62648412
139MP0003942_abnormal_urinary_system0.62613988
140MP0000631_abnormal_neuroendocrine_gland0.62443789
141MP0001286_abnormal_eye_development0.60781711
142* MP0002998_abnormal_bone_remodeling0.60577526
143MP0001943_abnormal_respiration0.58813689
144MP0005501_abnormal_skin_physiology0.58086228
145MP0005499_abnormal_olfactory_system0.58068963
146MP0005394_taste/olfaction_phenotype0.58068963
147MP0002139_abnormal_hepatobiliary_system0.57769670
148MP0000462_abnormal_digestive_system0.56929013
149MP0008770_decreased_survivor_rate0.55647312
150MP0000026_abnormal_inner_ear0.55507262
151MP0001984_abnormal_olfaction0.55270799
152MP0009053_abnormal_anal_canal0.54570098
153MP0002102_abnormal_ear_morphology0.54453678
154MP0000465_gastrointestinal_hemorrhage0.54313875
155MP0000490_abnormal_crypts_of0.53384822
156MP0003119_abnormal_digestive_system0.52754464
157MP0001177_atelectasis0.52649397
158MP0003385_abnormal_body_wall0.52535223
159MP0000358_abnormal_cell_content/0.52343094
160MP0003806_abnormal_nucleotide_metabolis0.50287344
161MP0002092_abnormal_eye_morphology0.50180488
162MP0003698_abnormal_male_reproductive0.49539767
163MP0000647_abnormal_sebaceous_gland0.48746277
164MP0006036_abnormal_mitochondrial_physio0.48689535
165MP0005379_endocrine/exocrine_gland_phen0.46828995
166MP0008775_abnormal_heart_ventricle0.45370628
167MP0000566_synostosis0.44140750
168MP0006138_congestive_heart_failure0.44112424
169MP0000678_abnormal_parathyroid_gland0.44002032
170MP0005166_decreased_susceptibility_to0.43745359
171MP0002234_abnormal_pharynx_morphology0.40047561
172MP0001243_abnormal_dermal_layer0.39557829
173MP0000534_abnormal_ureter_morphology0.38712571
174MP0004036_abnormal_muscle_relaxation0.36759395
175MP0000538_abnormal_urinary_bladder0.34489301
176MP0003941_abnormal_skin_development0.33054698
177MP0000377_abnormal_hair_follicle0.30489732

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)9.67811207
2Irregular epiphyses (HP:0010582)9.62913374
3Vitreoretinal degeneration (HP:0000655)8.57516305
4Hypoplastic ischia (HP:0003175)6.73024231
5Cupped ribs (HP:0000887)6.38003330
6Abnormal tarsal ossification (HP:0008369)6.35334924
7Small epiphyses (HP:0010585)6.30166011
8Abnormality of the ischium (HP:0003174)5.97511449
9Flat capital femoral epiphysis (HP:0003370)5.76086313
10Aplasia/Hypoplasia of the pubic bone (HP:0009104)5.63247292
11Flat acetabular roof (HP:0003180)5.42388564
12Delayed epiphyseal ossification (HP:0002663)5.35899892
13Abnormality of the labia minora (HP:0012880)5.34954536
14Genu varum (HP:0002970)5.11196273
15Colon cancer (HP:0003003)5.09396674
16Neonatal short-limb short stature (HP:0008921)4.79004043
17Abnormal foot bone ossification (HP:0010675)4.63786484
18Septo-optic dysplasia (HP:0100842)4.59520090
19Flattened epiphyses (HP:0003071)4.57380138
20Arthropathy (HP:0003040)4.51336330
21Metaphyseal cupping (HP:0003021)4.43289149
22Abnormality of femoral epiphyses (HP:0006499)4.41638560
23Abnormality involving the epiphyses of the lower limbs (HP:0006500)4.41638560
24Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)4.40493891
25Absent epiphyses (HP:0010577)4.40493891
26Abnormality of the vertebral endplates (HP:0005106)4.05734399
27Abnormality of the epiphysis of the femoral head (HP:0010574)3.95495139
28Mild short stature (HP:0003502)3.94593204
29Short femoral neck (HP:0100864)3.94090660
30Osteoarthritis (HP:0002758)3.82217250
31Metaphyseal irregularity (HP:0003025)3.71766227
32Abnormality of the femoral head (HP:0003368)3.68115003
33Irregular vertebral endplates (HP:0003301)3.64689256
34Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.61933306
35Birth length less than 3rd percentile (HP:0003561)3.44793404
36Protuberant abdomen (HP:0001538)3.44591437
37Abnormal vertebral ossification (HP:0100569)3.32784144
38Multiple enchondromatosis (HP:0005701)3.30212525
39Nephroblastoma (Wilms tumor) (HP:0002667)3.26118037
40Abnormality of the proximal phalanges of the hand (HP:0009834)3.23894664
41Abnormality of the phalanges of the 2nd finger (HP:0009541)3.22779800
42Abnormality of the pubic bones (HP:0003172)3.22491209
43Metaphyseal dysplasia (HP:0100255)3.21428646
44Barrel-shaped chest (HP:0001552)3.20275836
45Hypoglycemic seizures (HP:0002173)3.18866954
46Abnormal lung lobation (HP:0002101)3.18387657
47Chromosomal breakage induced by crosslinking agents (HP:0003221)3.16575521
48Cervical subluxation (HP:0003308)3.14299393
49Coxa vara (HP:0002812)3.13624635
50Reticulocytopenia (HP:0001896)3.10007221
51Meckel diverticulum (HP:0002245)3.09950199
52Hyperglycinemia (HP:0002154)3.06353529
53Abnormality of carpal bone ossification (HP:0006257)3.05957261
54Spastic diplegia (HP:0001264)3.03870559
55Embryonal renal neoplasm (HP:0011794)3.02659820
56Beaking of vertebral bodies (HP:0004568)3.01317447
57Thoracolumbar scoliosis (HP:0002944)2.98918737
58Ependymoma (HP:0002888)2.93362431
59Chromsome breakage (HP:0040012)2.93102471
60Choanal stenosis (HP:0000452)2.90149371
61Platyspondyly (HP:0000926)2.89355801
62Stenosis of the external auditory canal (HP:0000402)2.87783872
63Thin ribs (HP:0000883)2.86962689
64Absent septum pellucidum (HP:0001331)2.86772222
65Abnormality of the ileum (HP:0001549)2.85983144
66Maternal diabetes (HP:0009800)2.84501581
67Waddling gait (HP:0002515)2.84477922
68Vertebral clefting (HP:0008428)2.82063615
69Abnormality of chromosome stability (HP:0003220)2.79510310
70Ovoid vertebral bodies (HP:0003300)2.79038303
71Selective tooth agenesis (HP:0001592)2.78927175
72Aplasia/hypoplasia of the femur (HP:0005613)2.77433800
73Limited elbow extension (HP:0001377)2.76551314
74Glossoptosis (HP:0000162)2.75398425
75Abnormality of serum amino acid levels (HP:0003112)2.75236538
76Abnormality of the septum pellucidum (HP:0007375)2.72267741
77Abnormality of incisor morphology (HP:0011063)2.71794331
78Stillbirth (HP:0003826)2.70507448
79Homocystinuria (HP:0002156)2.70233165
80Abnormality of homocysteine metabolism (HP:0010919)2.70233165
81Absent frontal sinuses (HP:0002688)2.69190872
82Pancreatic islet-cell hyperplasia (HP:0004510)2.66405695
83Enlarged epiphyses (HP:0010580)2.64824022
84Abnormality of glycine metabolism (HP:0010895)2.64756125
85Abnormality of serine family amino acid metabolism (HP:0010894)2.64756125
86Fibular hypoplasia (HP:0003038)2.64325441
87Bilateral microphthalmos (HP:0007633)2.62988276
88Chronic bronchitis (HP:0004469)2.62826039
89Hyperinsulinemic hypoglycemia (HP:0000825)2.62077125
90Carpal bone hypoplasia (HP:0001498)2.60943076
91Limited hip movement (HP:0008800)2.60527540
92Rhabdomyosarcoma (HP:0002859)2.59962526
93Hyperglycinuria (HP:0003108)2.59868838
94Exostoses (HP:0100777)2.56665187
95Hypoplasia of the odontoid process (HP:0003311)2.55022024
96Hypoplastic pelvis (HP:0008839)2.49833584
97Abnormality of the vitreous humor (HP:0004327)2.49495269
98Hepatoblastoma (HP:0002884)2.49056350
99Lumbar hyperlordosis (HP:0002938)2.47189484
100Abnormality of the lumbar spine (HP:0100712)2.46539181
101Abnormality of the preputium (HP:0100587)2.45191510
102Abnormal hand bone ossification (HP:0010660)2.44191347
103Hip contracture (HP:0003273)2.43850239
104Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.43597627
105Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.42336133
106Vertebral hypoplasia (HP:0008417)2.42336133
107Abnormality of aspartate family amino acid metabolism (HP:0010899)2.38491429
108Cortical dysplasia (HP:0002539)2.38334537
109Abnormal hair whorl (HP:0010721)2.38221731
110Agnosia (HP:0010524)2.37897266
111Abnormality of methionine metabolism (HP:0010901)2.37882621
112Abnormal ossification of hand bones (HP:0005921)2.34203437
113Neoplasm of the colon (HP:0100273)2.33252764
114Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.32893988
115Long clavicles (HP:0000890)2.31716256
116Hypoplastic ilia (HP:0000946)2.29711534
117Breast aplasia (HP:0100783)2.29272708
118Aplasia/Hypoplasia of the uvula (HP:0010293)2.27887292
119Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.27873045
120Spinal cord compression (HP:0002176)2.27725777
121Disproportionate short-trunk short stature (HP:0003521)2.24061010
122Abnormality of the 2nd finger (HP:0004100)2.22840278
123Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.21342520
124Cellular immunodeficiency (HP:0005374)2.21307569
125Medulloblastoma (HP:0002885)2.20510196
126Symptomatic seizures (HP:0011145)2.19431669
127Aplasia/Hypoplasia of the breasts (HP:0010311)2.18441275
128Esophageal atresia (HP:0002032)2.18191691
129Absent radius (HP:0003974)2.17912783
130Abnormality of the phalanges of the 5th finger (HP:0004213)2.17535873
131Mesomelia (HP:0003027)2.15934184
132Increased hepatocellular lipid droplets (HP:0006565)2.15061567
133Horseshoe kidney (HP:0000085)2.15056574
134Small intestinal stenosis (HP:0012848)2.14616716
135Duodenal stenosis (HP:0100867)2.14616716
136Megaloblastic anemia (HP:0001889)2.14507757
137Facial cleft (HP:0002006)2.12330865
138Increased nuchal translucency (HP:0010880)2.11138827
139Micromelia (HP:0002983)2.10761916
140Macrocytic anemia (HP:0001972)2.10675584
141Biliary tract neoplasm (HP:0100574)2.10176070
142Aplasia/Hypoplasia of the sternum (HP:0006714)2.10002867
143Aplasia/Hypoplasia involving the vertebral column (HP:0008518)2.09482862
144Abnormality of the odontoid process (HP:0003310)2.09418371
145Abnormality of the duodenum (HP:0002246)2.06813828
146Broad phalanx (HP:0006009)2.03471019
147Oral leukoplakia (HP:0002745)2.03245220
148Abnormal number of incisors (HP:0011064)2.02970036
149Aplasia involving forearm bones (HP:0009822)2.02919426
150Absent forearm bone (HP:0003953)2.02919426
151Generalized hypotonia (HP:0001290)2.02320240
152Optic nerve hypoplasia (HP:0000609)2.02098965
153Short middle phalanx of finger (HP:0005819)2.01895857
154Short hallux (HP:0010109)2.01022544
155Mixed hearing impairment (HP:0000410)2.00867144
156Ectopic kidney (HP:0000086)2.00751812
157Acute encephalopathy (HP:0006846)1.97434486
158Abnormality of the clitoris (HP:0000056)1.96876928
159Relative macrocephaly (HP:0004482)1.96815314
160Methylmalonic acidemia (HP:0002912)1.96481454
161Hypoglycemic coma (HP:0001325)1.96418823
162Triphalangeal thumb (HP:0001199)1.95307406
163Aplasia/Hypoplasia of the hallux (HP:0008362)1.94496395
164Abnormality of sulfur amino acid metabolism (HP:0004339)1.94353050
165Abnormal number of erythroid precursors (HP:0012131)1.94171855
166Glioma (HP:0009733)1.93748369
167Bifid tongue (HP:0010297)1.93025247
168Tracheoesophageal fistula (HP:0002575)1.92752596
169Acute necrotizing encephalopathy (HP:0006965)1.91523904
170Broad long bones (HP:0005622)1.89494490
171Abnormality of cells of the erythroid lineage (HP:0012130)1.89194778
172Flared metaphyses (HP:0003015)1.89000684
173Supernumerary spleens (HP:0009799)1.87820322
174Neoplasm of the adrenal gland (HP:0100631)1.87562783
175Abnormality of the frontal sinuses (HP:0002687)1.87515182
176Aplasia/Hypoplasia of the scapulae (HP:0006713)1.87304999
177Hypoplastic scapulae (HP:0000882)1.87304999
178Aqueductal stenosis (HP:0002410)1.87275648
179Abnormality of the acetabulum (HP:0003170)1.86706732
180Tracheomalacia (HP:0002779)1.85579467
181Hypoplastic female external genitalia (HP:0012815)1.85072698
182Severe Myopia (HP:0011003)1.84929621
183Embryonal neoplasm (HP:0002898)1.83662669
184Abnormality of the lacrimal duct (HP:0011481)1.83270857
185Lipid accumulation in hepatocytes (HP:0006561)1.83079794
186Exercise-induced muscle cramps (HP:0003710)1.81989123
187Patent foramen ovale (HP:0001655)1.79945261
188Hypoplastic iliac wings (HP:0002866)1.79795863
189Broad thumb (HP:0011304)1.79596752
190Hypogonadotrophic hypogonadism (HP:0000044)1.79416903
191Genu valgum (HP:0002857)1.79206841
192Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.79060994
193Radial bowing (HP:0002986)1.78303037
194Methylmalonic aciduria (HP:0012120)1.76609568
195Abnormality of endocrine pancreas physiology (HP:0012093)1.76027570
196Abnormality of the pancreatic islet cells (HP:0006476)1.76027570
197Myelomeningocele (HP:0002475)1.75915108
198Neoplasm of the adrenal cortex (HP:0100641)1.75454435
199Sloping forehead (HP:0000340)1.74917127

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR27.97178574
2MAP3K36.87944114
3BUB14.58966765
4STK38L4.39430387
5CDC74.24743599
6NME14.21536206
7STK244.15092101
8PRKG23.76206112
9TTK3.55919025
10VRK23.44814176
11TSSK63.42792167
12PRKD33.31482163
13TNIK3.07867141
14TAF12.89463382
15MST42.88721347
16SRPK12.72467741
17ZAK2.52334059
18CDK192.36879727
19ERBB32.32613321
20PLK22.12613643
21MKNK21.84153682
22VRK11.73943303
23PLK41.72065391
24NEK11.71365553
25PLK11.70856736
26DYRK21.70814279
27NEK61.67205407
28EIF2AK31.65767203
29NUAK11.64972904
30PASK1.64310073
31WNK31.61109204
32DYRK1A1.60161354
33MAP3K101.54199194
34ALK1.52916959
35TAOK11.48042889
36TRPM71.45359664
37STK161.42113030
38DYRK31.38451327
39EPHB21.36227994
40TRIM281.29341075
41PBK1.25787498
42WEE11.22236434
43MET1.20733616
44BRSK21.20615789
45CHEK21.17550210
46STK31.14638552
47MAPK121.10699827
48MAPK71.10505661
49MKNK11.08756064
50PIM21.08355781
51ATR1.05893132
52TIE11.04530663
53ROCK11.02995340
54NEK20.98327523
55ACVR1B0.98308795
56EIF2AK10.97513202
57SMG10.95718223
58NME20.94396491
59BMPR1B0.90882728
60PDK20.87595667
61AURKB0.86109017
62ATM0.85515001
63STK390.84288131
64CHEK10.80929739
65FGFR20.77706294
66LATS10.77700946
67STK40.77696050
68GSK3A0.74220372
69MAPK40.74166359
70TAOK20.72886527
71PNCK0.71887884
72BCR0.71567314
73MAP3K110.70542814
74FGFR30.67820429
75CDK70.67024768
76PAK40.65907371
77LIMK10.64571233
78BMX0.62869772
79WNK40.62142842
80PRKCH0.62137335
81MAP2K30.61150677
82CSNK1E0.60313345
83SIK10.59912090
84TGFBR10.59715468
85FLT30.58324332
86PLK30.57496410
87PIK3CA0.57300760
88KDR0.55772672
89PRKDC0.55696865
90MAP3K90.54667520
91CSNK2A10.53847831
92AURKA0.51551534
93CSNK2A20.50662815
94CSNK1G20.50563824
95CDK10.50294238
96CASK0.49933794
97CDK20.48717741
98EPHA20.47613567
99DAPK10.46780083
100RPS6KA40.46032078
101DMPK0.45920189
102MST1R0.44908865
103PRKD20.44885504
104EPHA40.44747029
105MAP3K80.41900531
106NLK0.41800389
107GRK10.41635359
108CAMKK20.40330895
109LATS20.37798958
110PRKACG0.36947603
111PRKCD0.36292011
112CDK30.34958091
113FGFR10.34801634
114RPS6KB20.34630483
115MUSK0.34361813
116BMPR20.32393555
117PRKG10.31650588
118CSNK1G10.30487364
119RPS6KB10.30422000
120OXSR10.29912235
121KSR10.29325456
122PIM10.29153358
123MATK0.29092758
124MAP3K50.27582292
125SIK30.27203659
126PTK2B0.26776415
127CSNK1A1L0.26522646
128PRKCE0.25833113
129PAK10.25682623
130UHMK10.24907601
131MAPK130.24751876
132CDK40.24528029
133CAMK1D0.24048561
134ABL10.23802134
135CSNK1A10.23715104
136TRIB30.23599306
137BRAF0.23295878
138INSRR0.22784399
139CAMK1G0.22718033
140ERBB40.22278716
141IGF1R0.22184905
142TEC0.21888652
143SGK10.21798902
144FGR0.21092602
145PRKACA0.20976919
146MAPK30.20396299
147MELK0.19469383
148PRKCI0.18676496
149CAMK2D0.18519511
150EIF2AK20.18431911
151MAPK10.18027060
152BRSK10.16945334
153EPHB10.16506082
154MARK30.15517695
155STK100.15447196
156PDK10.15333121
157INSR0.15133271
158MAPK100.14342109
159ROCK20.14237627
160PRKCQ0.13690497
161PRKCA0.13633974
162PAK30.12472082
163ADRBK10.12068528
164TESK10.10899723
165CSNK1G30.10295510
166EGFR0.09659703
167IKBKB0.09338625
168CAMK2A0.07913539
169PRKCG0.06852898
170PINK10.06512780
171SGK2230.06240546

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005327.69155032
2ECM-receptor interaction_Homo sapiens_hsa045126.44193454
3Protein digestion and absorption_Homo sapiens_hsa049745.79293155
4DNA replication_Homo sapiens_hsa030304.00484885
5Mismatch repair_Homo sapiens_hsa034303.88374800
6Proteasome_Homo sapiens_hsa030503.50595196
7Non-homologous end-joining_Homo sapiens_hsa034503.10163367
8Sulfur metabolism_Homo sapiens_hsa009203.02094176
9RNA polymerase_Homo sapiens_hsa030202.92336468
10Steroid biosynthesis_Homo sapiens_hsa001002.87398995
11Sphingolipid metabolism_Homo sapiens_hsa006002.80208570
12Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.72338962
13Spliceosome_Homo sapiens_hsa030402.61887875
14Ribosome_Homo sapiens_hsa030102.60065377
15Homologous recombination_Homo sapiens_hsa034402.44391653
16RNA transport_Homo sapiens_hsa030132.40783231
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.40444350
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.40365613
19Base excision repair_Homo sapiens_hsa034102.38333857
20Cysteine and methionine metabolism_Homo sapiens_hsa002702.31275417
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.14135425
22Focal adhesion_Homo sapiens_hsa045102.12403303
23Cell cycle_Homo sapiens_hsa041102.03932368
24Protein export_Homo sapiens_hsa030602.00988302
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.94827008
26Vitamin B6 metabolism_Homo sapiens_hsa007501.92847913
27Starch and sucrose metabolism_Homo sapiens_hsa005001.84983455
28Olfactory transduction_Homo sapiens_hsa047401.83604904
29RNA degradation_Homo sapiens_hsa030181.74551231
30Malaria_Homo sapiens_hsa051441.74543934
31Biosynthesis of amino acids_Homo sapiens_hsa012301.74289432
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.72087982
33PI3K-Akt signaling pathway_Homo sapiens_hsa041511.68658768
34Other glycan degradation_Homo sapiens_hsa005111.68296209
35Nucleotide excision repair_Homo sapiens_hsa034201.66288725
36Fanconi anemia pathway_Homo sapiens_hsa034601.64580230
37TGF-beta signaling pathway_Homo sapiens_hsa043501.64132364
38Parkinsons disease_Homo sapiens_hsa050121.59134627
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.58876139
40Oxidative phosphorylation_Homo sapiens_hsa001901.55413628
41Pyruvate metabolism_Homo sapiens_hsa006201.52767759
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52236797
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.49571059
44mRNA surveillance pathway_Homo sapiens_hsa030151.47708667
45Pyrimidine metabolism_Homo sapiens_hsa002401.41460572
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.37381181
47Arginine and proline metabolism_Homo sapiens_hsa003301.32377237
48Huntingtons disease_Homo sapiens_hsa050161.31836750
49Propanoate metabolism_Homo sapiens_hsa006401.27608141
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.24886734
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.24303791
52Purine metabolism_Homo sapiens_hsa002301.17553588
53Ovarian steroidogenesis_Homo sapiens_hsa049131.10390780
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08973997
55Carbon metabolism_Homo sapiens_hsa012001.08312683
56Selenocompound metabolism_Homo sapiens_hsa004501.07532774
57Fatty acid elongation_Homo sapiens_hsa000621.06876114
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05313014
59SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01903400
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00972857
61Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.00824163
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96687913
63Proteoglycans in cancer_Homo sapiens_hsa052050.96099412
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95286381
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94779130
66Alzheimers disease_Homo sapiens_hsa050100.83783779
67Oocyte meiosis_Homo sapiens_hsa041140.82087496
68Hippo signaling pathway_Homo sapiens_hsa043900.79559696
69Arachidonic acid metabolism_Homo sapiens_hsa005900.78737758
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75870237
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74183050
72Folate biosynthesis_Homo sapiens_hsa007900.72974103
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.71562711
74p53 signaling pathway_Homo sapiens_hsa041150.69161872
75Hedgehog signaling pathway_Homo sapiens_hsa043400.66364691
76Tight junction_Homo sapiens_hsa045300.66077087
77Vibrio cholerae infection_Homo sapiens_hsa051100.65061282
78Long-term depression_Homo sapiens_hsa047300.65035072
79Phagosome_Homo sapiens_hsa041450.64552431
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63515826
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63177548
82Cardiac muscle contraction_Homo sapiens_hsa042600.61194193
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58243802
84Basal cell carcinoma_Homo sapiens_hsa052170.56877388
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55835981
86Salivary secretion_Homo sapiens_hsa049700.54301962
87Thyroid hormone synthesis_Homo sapiens_hsa049180.52097197
88One carbon pool by folate_Homo sapiens_hsa006700.52044263
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51373673
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50154301
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49572566
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48966695
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44645519
94Galactose metabolism_Homo sapiens_hsa000520.44330580
95Dilated cardiomyopathy_Homo sapiens_hsa054140.44009304
96beta-Alanine metabolism_Homo sapiens_hsa004100.43531384
97Retinol metabolism_Homo sapiens_hsa008300.42703947
98Lysine degradation_Homo sapiens_hsa003100.42145354
99Circadian entrainment_Homo sapiens_hsa047130.41572412
100Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.41273027
101Complement and coagulation cascades_Homo sapiens_hsa046100.40171778
102N-Glycan biosynthesis_Homo sapiens_hsa005100.39749865
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39718839
104Fatty acid degradation_Homo sapiens_hsa000710.39237668
105Wnt signaling pathway_Homo sapiens_hsa043100.37896630
106Fatty acid metabolism_Homo sapiens_hsa012120.36623437
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36187643
108HIF-1 signaling pathway_Homo sapiens_hsa040660.36010784
109Gap junction_Homo sapiens_hsa045400.35753369
110Epstein-Barr virus infection_Homo sapiens_hsa051690.34970812
111Aldosterone synthesis and secretion_Homo sapiens_hsa049250.34606072
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32793999
113Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31533208
114Fat digestion and absorption_Homo sapiens_hsa049750.27862720
115Hematopoietic cell lineage_Homo sapiens_hsa046400.27670233
116Pentose phosphate pathway_Homo sapiens_hsa000300.26981463
117Tryptophan metabolism_Homo sapiens_hsa003800.26548359
118Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26453887
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.26057143
120Melanogenesis_Homo sapiens_hsa049160.25752509
121Oxytocin signaling pathway_Homo sapiens_hsa049210.25188980
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.24065659
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.22399592
124Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.21726164
125Taste transduction_Homo sapiens_hsa047420.21184187
126Renal cell carcinoma_Homo sapiens_hsa052110.20496361
127Glutathione metabolism_Homo sapiens_hsa004800.19597713
128Sulfur relay system_Homo sapiens_hsa041220.18979046
129Amphetamine addiction_Homo sapiens_hsa050310.18888822
130Axon guidance_Homo sapiens_hsa043600.18360358
131Peroxisome_Homo sapiens_hsa041460.18022352
132Mineral absorption_Homo sapiens_hsa049780.17968189
133Nicotine addiction_Homo sapiens_hsa050330.17847549
134Colorectal cancer_Homo sapiens_hsa052100.17609060
135Steroid hormone biosynthesis_Homo sapiens_hsa001400.16909319
136Metabolic pathways_Homo sapiens_hsa011000.16798613
137Basal transcription factors_Homo sapiens_hsa030220.16695890
138Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.16341688
139Cyanoamino acid metabolism_Homo sapiens_hsa004600.16110923
140Phototransduction_Homo sapiens_hsa047440.13593085
141cAMP signaling pathway_Homo sapiens_hsa040240.12410036
142Bladder cancer_Homo sapiens_hsa052190.12102944
143Cocaine addiction_Homo sapiens_hsa050300.12075189
144Chemical carcinogenesis_Homo sapiens_hsa052040.11652085
145Ether lipid metabolism_Homo sapiens_hsa005650.11390889
146Systemic lupus erythematosus_Homo sapiens_hsa053220.10554058
147Arginine biosynthesis_Homo sapiens_hsa002200.10143409
148Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.08371397
149Bile secretion_Homo sapiens_hsa049760.08132970
150MicroRNAs in cancer_Homo sapiens_hsa052060.08059190
151Thyroid hormone signaling pathway_Homo sapiens_hsa049190.07336574
152Neurotrophin signaling pathway_Homo sapiens_hsa047220.07279542
153ErbB signaling pathway_Homo sapiens_hsa040120.06974137
154Adherens junction_Homo sapiens_hsa045200.06394138
155Insulin secretion_Homo sapiens_hsa049110.06003464
156Cholinergic synapse_Homo sapiens_hsa047250.05749325
157Serotonergic synapse_Homo sapiens_hsa047260.05277634
158Renin secretion_Homo sapiens_hsa049240.04743611
159Platelet activation_Homo sapiens_hsa046110.04328232
160Thyroid cancer_Homo sapiens_hsa052160.03783344
161Sphingolipid signaling pathway_Homo sapiens_hsa040710.03575522
162Vitamin digestion and absorption_Homo sapiens_hsa049770.02555061
163Insulin resistance_Homo sapiens_hsa049310.02366498
164Longevity regulating pathway - mammal_Homo sapiens_hsa042110.02246588
165Legionellosis_Homo sapiens_hsa051340.02245870
166Ras signaling pathway_Homo sapiens_hsa040140.01852755

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