LECT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted, 16 kDa protein that acts as a chemotactic factor to neutrophils and stimulates the growth of chondrocytes and osteoblasts. This protein has high sequence similarity to the chondromodulin repeat regions of the chicken myb-induced myeloid 1 protein. A polymorphism in this gene may be associated with rheumatoid arthritis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.66865677
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.66865677
3L-phenylalanine metabolic process (GO:0006558)7.32839073
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.32839073
5aromatic amino acid family catabolic process (GO:0009074)6.85880954
6exogenous drug catabolic process (GO:0042738)6.54277780
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.50134951
8epoxygenase P450 pathway (GO:0019373)6.41508445
9omega-hydroxylase P450 pathway (GO:0097267)6.26882365
10indole-containing compound catabolic process (GO:0042436)6.12784627
11indolalkylamine catabolic process (GO:0046218)6.12784627
12tryptophan catabolic process (GO:0006569)6.12784627
13oxidative demethylation (GO:0070989)6.04579460
14kynurenine metabolic process (GO:0070189)6.00865090
15bile acid biosynthetic process (GO:0006699)5.92378321
16glyoxylate metabolic process (GO:0046487)5.81700233
17tryptophan metabolic process (GO:0006568)5.76889006
18high-density lipoprotein particle remodeling (GO:0034375)5.73565288
19negative regulation of fibrinolysis (GO:0051918)5.68270219
20urea metabolic process (GO:0019627)5.65564522
21urea cycle (GO:0000050)5.65564522
22alpha-linolenic acid metabolic process (GO:0036109)5.63254945
23regulation of fibrinolysis (GO:0051917)5.46761491
24protein carboxylation (GO:0018214)5.40948788
25peptidyl-glutamic acid carboxylation (GO:0017187)5.40948788
26sulfur amino acid catabolic process (GO:0000098)5.35230442
27cysteine metabolic process (GO:0006534)5.34244820
28complement activation, alternative pathway (GO:0006957)5.29723512
29regulation of protein activation cascade (GO:2000257)5.23491393
30nitrogen cycle metabolic process (GO:0071941)5.20032556
31serine family amino acid catabolic process (GO:0009071)5.15219266
32drug metabolic process (GO:0017144)5.12826624
33bile acid metabolic process (GO:0008206)5.11089163
34regulation of cholesterol esterification (GO:0010872)5.03836755
35reverse cholesterol transport (GO:0043691)4.98634392
36aromatic amino acid family metabolic process (GO:0009072)4.98233751
37phenylpropanoid metabolic process (GO:0009698)4.97690235
38regulation of triglyceride catabolic process (GO:0010896)4.88858852
39plasma lipoprotein particle remodeling (GO:0034369)4.88269027
40protein-lipid complex remodeling (GO:0034368)4.88269027
41macromolecular complex remodeling (GO:0034367)4.88269027
42tyrosine metabolic process (GO:0006570)4.87270380
43regulation of complement activation (GO:0030449)4.87245583
44fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.79379340
45homocysteine metabolic process (GO:0050667)4.73024348
46phospholipid efflux (GO:0033700)4.70486941
47negative regulation of cholesterol transport (GO:0032375)4.69540030
48negative regulation of sterol transport (GO:0032372)4.69540030
49triglyceride homeostasis (GO:0070328)4.68549114
50acylglycerol homeostasis (GO:0055090)4.68549114
51alpha-amino acid catabolic process (GO:1901606)4.64707229
52amino-acid betaine metabolic process (GO:0006577)4.59774859
53cellular ketone body metabolic process (GO:0046950)4.56918432
54lysine catabolic process (GO:0006554)4.54344879
55lysine metabolic process (GO:0006553)4.54344879
56plasma lipoprotein particle clearance (GO:0034381)4.47771196
57alkaloid metabolic process (GO:0009820)4.47663150
58glycine metabolic process (GO:0006544)4.47114385
59bile acid and bile salt transport (GO:0015721)4.43864480
60indolalkylamine metabolic process (GO:0006586)4.34154712
61coenzyme catabolic process (GO:0009109)4.31448838
62cholesterol efflux (GO:0033344)4.31031550
63imidazole-containing compound metabolic process (GO:0052803)4.30386268
64cellular glucuronidation (GO:0052695)4.29295290
65cellular amino acid catabolic process (GO:0009063)4.26977613
66cellular biogenic amine catabolic process (GO:0042402)4.25520472
67amine catabolic process (GO:0009310)4.25520472
68glutamate metabolic process (GO:0006536)4.21235774
69ethanol metabolic process (GO:0006067)4.18142680
70serine family amino acid metabolic process (GO:0009069)4.18052813
71benzene-containing compound metabolic process (GO:0042537)4.15450268
72aldehyde catabolic process (GO:0046185)4.10717915
73low-density lipoprotein particle remodeling (GO:0034374)4.10522069
74plasma lipoprotein particle assembly (GO:0034377)4.07802888
75ethanol oxidation (GO:0006069)4.07241790
76dicarboxylic acid biosynthetic process (GO:0043650)4.04240940
77serine family amino acid biosynthetic process (GO:0009070)4.03946798
78arginine metabolic process (GO:0006525)4.03165438
79fibrinolysis (GO:0042730)4.02605135
80cellular modified amino acid catabolic process (GO:0042219)4.01835984
81ketone body metabolic process (GO:1902224)3.95594087
82drug catabolic process (GO:0042737)3.95461976
83negative regulation of protein activation cascade (GO:2000258)3.92547129
84blood coagulation, intrinsic pathway (GO:0007597)3.89204919
85S-adenosylmethionine metabolic process (GO:0046500)3.85891985
86positive regulation of triglyceride lipase activity (GO:0061365)3.84836881
87positive regulation of lipoprotein lipase activity (GO:0051006)3.84836881
88negative regulation of lipase activity (GO:0060192)3.83717173
89glucuronate metabolic process (GO:0019585)3.80882695
90uronic acid metabolic process (GO:0006063)3.80882695
91positive regulation of lipid catabolic process (GO:0050996)3.80128901
92very-low-density lipoprotein particle assembly (GO:0034379)3.79656910
93cofactor catabolic process (GO:0051187)3.77758670
94cholesterol homeostasis (GO:0042632)3.77241936
95phospholipid homeostasis (GO:0055091)3.75382336
96flavonoid metabolic process (GO:0009812)3.75351116
97organic acid catabolic process (GO:0016054)3.74261558
98carboxylic acid catabolic process (GO:0046395)3.74261558
99pyrimidine nucleobase catabolic process (GO:0006208)3.72831905
100complement activation, classical pathway (GO:0006958)3.72389508
101arginine catabolic process (GO:0006527)3.71732558
102regulation of bile acid biosynthetic process (GO:0070857)3.71270488
103protein activation cascade (GO:0072376)3.71253227
104negative regulation of complement activation (GO:0045916)3.71179547
105complement activation (GO:0006956)3.71099622
106sterol homeostasis (GO:0055092)3.70950690
107plasma lipoprotein particle organization (GO:0071827)3.69866460
108short-chain fatty acid metabolic process (GO:0046459)3.68475581
109protein-lipid complex assembly (GO:0065005)3.65561434
110acetyl-CoA metabolic process (GO:0006084)3.60352651
111NAD biosynthetic process (GO:0009435)3.59646148
112nicotinamide nucleotide biosynthetic process (GO:0019359)3.56359965
113pyridine nucleotide biosynthetic process (GO:0019363)3.56359965
114xenobiotic catabolic process (GO:0042178)3.55328899
115regulation of cholesterol homeostasis (GO:2000188)3.54759012
116L-methionine salvage (GO:0071267)3.53371959
117L-methionine biosynthetic process (GO:0071265)3.53371959
118amino acid salvage (GO:0043102)3.53371959
119regulation of plasminogen activation (GO:0010755)3.39668758
120drug transmembrane transport (GO:0006855)3.36467928
121nucleobase catabolic process (GO:0046113)3.34650693
122steroid catabolic process (GO:0006706)3.34256434
123negative regulation of hemostasis (GO:1900047)3.25716161
124negative regulation of blood coagulation (GO:0030195)3.25716161
125detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.22714841
126xenobiotic metabolic process (GO:0006805)3.22066184
127heme transport (GO:0015886)3.17503932
128indole-containing compound metabolic process (GO:0042430)3.14815922
129cellular response to sterol (GO:0036315)3.06063302
130peptidyl-glutamic acid modification (GO:0018200)3.05896521
131negative regulation of coagulation (GO:0050819)3.03944465
132negative regulation of wound healing (GO:0061045)2.98824002
133regulation of humoral immune response (GO:0002920)2.94458546

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.43314735
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.21270359
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse7.06422316
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.54041439
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.28866481
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.18503360
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.86252849
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.04499439
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.04142636
10GBX2_23144817_ChIP-Seq_PC3_Human3.10495221
11* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.82929838
12VDR_22108803_ChIP-Seq_LS180_Human2.77532210
13ZNF274_21170338_ChIP-Seq_K562_Hela2.67464478
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.57294776
15IGF1R_20145208_ChIP-Seq_DFB_Human2.51653122
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.49030956
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.18993566
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.11189982
19ER_23166858_ChIP-Seq_MCF-7_Human2.10900923
20* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.05839574
21P300_19829295_ChIP-Seq_ESCs_Human2.02980515
22HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.01790080
23AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.00019155
24* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9710930
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95353841
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.94622964
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.93009633
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86560540
29FUS_26573619_Chip-Seq_HEK293_Human1.77096453
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.76473763
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.76360712
32EZH2_27294783_Chip-Seq_NPCs_Mouse1.72320629
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72185688
34PCGF2_27294783_Chip-Seq_NPCs_Mouse1.70174789
35EWS_26573619_Chip-Seq_HEK293_Human1.68860929
36STAT3_23295773_ChIP-Seq_U87_Human1.68369852
37NFE2_27457419_Chip-Seq_LIVER_Mouse1.67534071
38IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.66572352
39CBP_20019798_ChIP-Seq_JUKART_Human1.66572352
40UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.65074977
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64357110
42HTT_18923047_ChIP-ChIP_STHdh_Human1.62529420
43SMAD4_21799915_ChIP-Seq_A2780_Human1.61717463
44FOXA2_19822575_ChIP-Seq_HepG2_Human1.60524658
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58279321
46TCF4_23295773_ChIP-Seq_U87_Human1.57155356
47IRF1_19129219_ChIP-ChIP_H3396_Human1.52649451
48CLOCK_20551151_ChIP-Seq_293T_Human1.51769663
49AR_25329375_ChIP-Seq_VCAP_Human1.47774499
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46683734
51CRX_20693478_ChIP-Seq_RETINA_Mouse1.44119469
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.43309474
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43097890
54TCF4_22108803_ChIP-Seq_LS180_Human1.42104611
55GATA1_22025678_ChIP-Seq_K562_Human1.41838387
56KLF5_20875108_ChIP-Seq_MESCs_Mouse1.41322512
57HNF4A_19822575_ChIP-Seq_HepG2_Human1.40977847
58SOX2_19829295_ChIP-Seq_ESCs_Human1.39916896
59NANOG_19829295_ChIP-Seq_ESCs_Human1.39916896
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39405523
61GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.38227597
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.36414295
63NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35825427
64EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.34476226
65EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.34322622
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.32250256
67* RUNX2_22187159_ChIP-Seq_PCA_Human1.31376033
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31325318
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30420738
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30030233
71EZH2_22144423_ChIP-Seq_EOC_Human1.28274210
72OCT4_21477851_ChIP-Seq_ESCs_Mouse1.27956687
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25666770
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23282236
75SMAD4_21741376_ChIP-Seq_EPCs_Human1.22453479
76FOXA1_21572438_ChIP-Seq_LNCaP_Human1.22411776
77P53_22387025_ChIP-Seq_ESCs_Mouse1.20734220
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19082117
79STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18625973
80FLI1_21867929_ChIP-Seq_TH2_Mouse1.18196944
81* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.18167813
82E2F1_18555785_Chip-Seq_ESCs_Mouse1.17677320
83FOXA1_25329375_ChIP-Seq_VCAP_Human1.16118253
84FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16118253
85STAT3_18555785_Chip-Seq_ESCs_Mouse1.15790502
86TP53_22573176_ChIP-Seq_HFKS_Human1.15414591
87P300_18555785_Chip-Seq_ESCs_Mouse1.12471629
88CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12262542
89ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11973711
90* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11749302
91* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11749302
92TP53_16413492_ChIP-PET_HCT116_Human1.11510235
93TP53_18474530_ChIP-ChIP_U2OS_Human1.08940474
94PRDM14_20953172_ChIP-Seq_ESCs_Human1.08710641
95CMYC_18555785_Chip-Seq_ESCs_Mouse1.08299255
96EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.07389972
97SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07102099
98MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06590176
99FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04312642
100ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03923540
101TAL1_26923725_Chip-Seq_HPCs_Mouse1.03888378
102ETV1_20927104_ChIP-Seq_GIST48_Human1.03417037
103ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02858551
104IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01805733
105SOX2_18555785_Chip-Seq_ESCs_Mouse1.01678687
106PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96699153
107TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95927689
108SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91100624
109PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86706897
110AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85301567
111RARG_19884340_ChIP-ChIP_MEFs_Mouse0.81841513
112GATA4_25053715_ChIP-Seq_YYC3_Human0.81546594
113ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81165232
114IRF8_22096565_ChIP-ChIP_GC-B_Human0.81099287
115KAP1_22055183_ChIP-Seq_ESCs_Mouse0.79651915
116ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79215349
117SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76387348
118BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75343711
119RARA_24833708_ChIP-Seq_LIVER_Mouse0.74274774
120SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.72351602
121ZNF263_19887448_ChIP-Seq_K562_Human0.71555450
122Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.70637517
123NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.68774810
124* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.67019290
125SALL4_18804426_ChIP-ChIP_XEN_Mouse0.66768788
126AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.66284477
127NRF2_20460467_ChIP-Seq_MEFs_Mouse0.64466631
128NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.64466631
129ESR2_21235772_ChIP-Seq_MCF-7_Human0.62801164
130RAD21_21589869_ChIP-Seq_MESCs_Mouse0.62271757
131RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.62099948
132* RARB_24833708_ChIP-Seq_LIVER_Mouse0.61888345
133BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61639222
134NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.61154476
135NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.60547832
136CEBPB_22108803_ChIP-Seq_LS180_Human0.57873308
137E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.56403626
138FOXA1_25552417_ChIP-Seq_VCAP_Human0.52548151
139AR_20517297_ChIP-Seq_VCAP_Human0.52472057
140EGR1_19032775_ChIP-ChIP_M12_Human0.52359326
141LXR_22292898_ChIP-Seq_THP-1_Human0.51625857
142MYC_19915707_ChIP-ChIP_AK7_Human0.51458485
143* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.50808167
144STAT1_17558387_ChIP-Seq_HELA_Human0.50706766
145ESET_19884257_ChIP-Seq_ESCs_Mouse0.50224535
146FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49436813
147CBP_21632823_ChIP-Seq_H3396_Human0.48848890
148STAT3_1855785_ChIP-Seq_MESCs_Mouse0.48305966
149* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.48127188
150P53_21459846_ChIP-Seq_SAOS-2_Human0.47009948
151PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45761764
152PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.45216057
153TAF15_26573619_Chip-Seq_HEK293_Human0.44723132
154CDX2_20551321_ChIP-Seq_CACO-2_Human0.43554095
155ERG_21242973_ChIP-ChIP_JURKAT_Human0.42783534
156GATA1_19941827_ChIP-Seq_MEL_Mouse0.42599373
157FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.42223893
158GATA1_19941826_ChIP-Seq_K562_Human0.41983532
159* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.41563333
160TAF2_19829295_ChIP-Seq_ESCs_Human0.41443335
161GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.41203315
162ESR1_21235772_ChIP-Seq_MCF-7_Human0.40974919
163BCAT_22108803_ChIP-Seq_LS180_Human0.40812579
164SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40456979
165CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.40205659
166FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.40157564
167GATA2_19941826_ChIP-Seq_K562_Human0.39952226
168FOXO3_23340844_ChIP-Seq_DLD1_Human0.38504595
169PPAR_26484153_Chip-Seq_NCI-H1993_Human0.37560029
170STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.37547036
171MYC_27129775_Chip-Seq_CORNEA_Mouse0.36979741
172LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.36499623
173ESR1_20079471_ChIP-ChIP_T-47D_Human0.36137084
174SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.36034958
175SPI1_26923725_Chip-Seq_HPCs_Mouse0.35669324
176NCOR_22424771_ChIP-Seq_293T_Human0.35648068
177* GATA6_25053715_ChIP-Seq_YYC3_Human0.35385707
178FOXH1_21741376_ChIP-Seq_EPCs_Human0.34507717
179SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.33253066
180CDX2_22108803_ChIP-Seq_LS180_Human0.33053257

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.41429028
2MP0005360_urolithiasis7.58591588
3MP0005085_abnormal_gallbladder_physiolo6.46041101
4MP0005365_abnormal_bile_salt6.14688413
5MP0008875_abnormal_xenobiotic_pharmacok5.21718961
6MP0003806_abnormal_nucleotide_metabolis4.26185737
7MP0003252_abnormal_bile_duct3.89748099
8MP0010329_abnormal_lipoprotein_level3.60737258
9MP0009840_abnormal_foam_cell3.35742979
10MP0005083_abnormal_biliary_tract3.04812654
11MP0003195_calcinosis2.83026740
12MP0005332_abnormal_amino_acid2.73917063
13MP0001666_abnormal_nutrient_absorption2.58685006
14MP0003191_abnormal_cellular_cholesterol2.32187786
15MP0004019_abnormal_vitamin_homeostasis2.15824092
16* MP0000609_abnormal_liver_physiology2.12880924
17MP0002118_abnormal_lipid_homeostasis2.09237104
18MP0002138_abnormal_hepatobiliary_system1.93529356
19MP0003868_abnormal_feces_composition1.91205869
20MP0005551_abnormal_eye_electrophysiolog1.84133879
21MP0005319_abnormal_enzyme/_coenzyme1.81880375
22MP0000569_abnormal_digit_pigmentation1.70847642
23MP0001764_abnormal_homeostasis1.66949930
24MP0009697_abnormal_copulation1.65698802
25MP0005584_abnormal_enzyme/coenzyme_acti1.57401352
26MP0000372_irregular_coat_pigmentation1.56794253
27MP0006292_abnormal_olfactory_placode1.51523713
28MP0005451_abnormal_body_composition1.46252233
29MP0003011_delayed_dark_adaptation1.40428700
30MP0001968_abnormal_touch/_nociception1.37978528
31MP0002736_abnormal_nociception_after1.37631991
32MP0005646_abnormal_pituitary_gland1.35345398
33MP0003656_abnormal_erythrocyte_physiolo1.29782533
34MP0003186_abnormal_redox_activity1.27490026
35MP0001501_abnormal_sleep_pattern1.27186077
36MP0001986_abnormal_taste_sensitivity1.26237025
37MP0010386_abnormal_urinary_bladder1.22399636
38MP0009643_abnormal_urine_homeostasis1.22171037
39MP0009745_abnormal_behavioral_response1.20582390
40MP0003880_abnormal_central_pattern1.19872560
41MP0000598_abnormal_liver_morphology1.17113897
42MP0005647_abnormal_sex_gland1.13101048
43MP0003705_abnormal_hypodermis_morpholog1.11660686
44MP0002938_white_spotting1.10336733
45MP0002102_abnormal_ear_morphology1.09976801
46MP0000604_amyloidosis1.09274610
47MP0009764_decreased_sensitivity_to1.06820516
48MP0003646_muscle_fatigue1.05435835
49MP0009046_muscle_twitch1.03507609
50MP0009763_increased_sensitivity_to1.03121601
51MP0006276_abnormal_autonomic_nervous1.01070989
52MP0002254_reproductive_system_inflammat1.00073596
53MP0008877_abnormal_DNA_methylation0.99287261
54MP0005187_abnormal_penis_morphology0.99019847
55MP0010368_abnormal_lymphatic_system0.98035248
56MP0005253_abnormal_eye_physiology0.97601881
57MP0004043_abnormal_pH_regulation0.93888200
58MP0002282_abnormal_trachea_morphology0.93750302
59MP0005645_abnormal_hypothalamus_physiol0.93733405
60MP0005636_abnormal_mineral_homeostasis0.91527097
61MP0008469_abnormal_protein_level0.88174201
62MP0005408_hypopigmentation0.87135885
63MP0009642_abnormal_blood_homeostasis0.86687604
64MP0001485_abnormal_pinna_reflex0.85188223
65MP0003136_yellow_coat_color0.83463899
66MP0006036_abnormal_mitochondrial_physio0.82458657
67MP0002638_abnormal_pupillary_reflex0.82291665
68MP0002272_abnormal_nervous_system0.81952461
69MP0002234_abnormal_pharynx_morphology0.80912345
70MP0001486_abnormal_startle_reflex0.80799032
71MP0005376_homeostasis/metabolism_phenot0.79630167
72MP0009765_abnormal_xenobiotic_induced0.79248308
73MP0005410_abnormal_fertilization0.77888109
74MP0002078_abnormal_glucose_homeostasis0.77174077
75MP0004924_abnormal_behavior0.76936836
76MP0005386_behavior/neurological_phenoty0.76936836
77MP0001984_abnormal_olfaction0.76861558
78MP0002876_abnormal_thyroid_physiology0.76602065
79MP0003950_abnormal_plasma_membrane0.74778148
80MP0005670_abnormal_white_adipose0.73764724
81MP0000427_abnormal_hair_cycle0.72458809
82MP0005084_abnormal_gallbladder_morpholo0.72439692
83MP0001529_abnormal_vocalization0.72107232
84MP0006072_abnormal_retinal_apoptosis0.70886554
85MP0001324_abnormal_eye_pigmentation0.70828117
86MP0002971_abnormal_brown_adipose0.70231777
87MP0005220_abnormal_exocrine_pancreas0.69351718
88MP0001661_extended_life_span0.68354078
89MP0005334_abnormal_fat_pad0.67680122
90MP0004147_increased_porphyrin_level0.67063945
91MP0004130_abnormal_muscle_cell0.66974361
92MP0003690_abnormal_glial_cell0.66859339
93MP0004142_abnormal_muscle_tone0.66670692
94MP0002735_abnormal_chemical_nociception0.66314728
95MP0009053_abnormal_anal_canal0.65934251
96MP0005535_abnormal_body_temperature0.65431659
97MP0000371_diluted_coat_color0.64498225
98MP0004215_abnormal_myocardial_fiber0.64017819
99MP0005266_abnormal_metabolism0.63990467
100MP0002557_abnormal_social/conspecific_i0.63873967
101MP0002572_abnormal_emotion/affect_behav0.62466672
102MP0000639_abnormal_adrenal_gland0.61774042
103MP0003329_amyloid_beta_deposits0.61625866
104MP0002064_seizures0.59869830
105MP0005195_abnormal_posterior_eye0.58642235
106MP0000631_abnormal_neuroendocrine_gland0.58564827
107MP0001756_abnormal_urination0.56972616
108MP0005174_abnormal_tail_pigmentation0.56633498
109MP0004133_heterotaxia0.56467038
110MP0005448_abnormal_energy_balance0.54943923
111MP0003698_abnormal_male_reproductive0.54927185
112MP0002067_abnormal_sensory_capabilities0.54727367
113MP0002229_neurodegeneration0.53883745
114MP0005464_abnormal_platelet_physiology0.53782165
115MP0006035_abnormal_mitochondrial_morpho0.53280982
116MP0002822_catalepsy0.50681685
117MP0005395_other_phenotype0.48840561
118MP0003718_maternal_effect0.48586237
119MP0003638_abnormal_response/metabolism_0.46447370
120MP0008874_decreased_physiological_sensi0.46413113
121MP0008873_increased_physiological_sensi0.45654405
122MP0002136_abnormal_kidney_physiology0.43818592
123MP0002837_dystrophic_cardiac_calcinosis0.43807169
124MP0002928_abnormal_bile_duct0.43116608
125MP0004782_abnormal_surfactant_physiolog0.42459975
126MP0003436_decreased_susceptibility_to0.42258398
127MP0008872_abnormal_physiological_respon0.41289183
128MP0003075_altered_response_to0.41021132
129MP0005248_abnormal_Harderian_gland0.40469814
130MP0003953_abnormal_hormone_level0.40447742
131MP0003724_increased_susceptibility_to0.40302925
132MP0009672_abnormal_birth_weight0.37312414
133MP0005166_decreased_susceptibility_to0.37028548
134MP0005666_abnormal_adipose_tissue0.34201143
135MP0000249_abnormal_blood_vessel0.33455123
136MP0004883_abnormal_blood_vessel0.33325466
137MP0004381_abnormal_hair_follicle0.33169929
138MP0006082_CNS_inflammation0.32786206
139MP0001243_abnormal_dermal_layer0.32220560
140MP0000579_abnormal_nail_morphology0.32155895
141MP0002796_impaired_skin_barrier0.31822197
142MP0009115_abnormal_fat_cell0.30912356
143MP0000230_abnormal_systemic_arterial0.30845547
144MP0002168_other_aberrant_phenotype0.29207805
145MP0002970_abnormal_white_adipose0.29201572
146MP0001853_heart_inflammation0.28631595
147MP0001881_abnormal_mammary_gland0.28438927
148MP0009384_cardiac_valve_regurgitation0.27420177
149MP0002132_abnormal_respiratory_system0.26899480
150* MP0001845_abnormal_inflammatory_respons0.25442091
151MP0005164_abnormal_response_to0.25351713
152MP0002090_abnormal_vision0.24083123
153MP0005167_abnormal_blood-brain_barrier0.23587179

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.53755381
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.49538278
3Intrahepatic cholestasis (HP:0001406)7.31574358
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.66234186
5Prolonged partial thromboplastin time (HP:0003645)6.64509868
6Hypobetalipoproteinemia (HP:0003563)6.54767076
7Xanthomatosis (HP:0000991)6.28899158
8Hyperlipoproteinemia (HP:0010980)5.68752969
9Complement deficiency (HP:0004431)5.20841399
10Hypolipoproteinemia (HP:0010981)4.88867023
11Joint hemorrhage (HP:0005261)4.85781339
12Hyperammonemia (HP:0001987)4.62624846
13Abnormality of the common coagulation pathway (HP:0010990)4.47463919
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.46936396
15Hyperglycinemia (HP:0002154)4.45758408
16Epidermoid cyst (HP:0200040)4.45095147
17Abnormality of methionine metabolism (HP:0010901)4.28225304
18Ketosis (HP:0001946)4.26081527
19Hypoalphalipoproteinemia (HP:0003233)4.26030816
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.23432701
21Abnormality of aspartate family amino acid metabolism (HP:0010899)4.10394942
22Fat malabsorption (HP:0002630)4.10125804
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.09874695
24Hypoglycemic coma (HP:0001325)3.92803174
25Abnormality of serine family amino acid metabolism (HP:0010894)3.92335308
26Abnormality of glycine metabolism (HP:0010895)3.92335308
27Hyperglycinuria (HP:0003108)3.91192316
28Abnormality of pyrimidine metabolism (HP:0004353)3.82746324
29Abnormality of the intrinsic pathway (HP:0010989)3.81754680
30Fair hair (HP:0002286)3.81260751
31Abnormality of complement system (HP:0005339)3.80271245
32Conjugated hyperbilirubinemia (HP:0002908)3.71075821
33Hypercholesterolemia (HP:0003124)3.65357385
34Hyperbilirubinemia (HP:0002904)3.39007938
35Hyperventilation (HP:0002883)3.36054630
36Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.35348627
37Abnormality of fatty-acid metabolism (HP:0004359)3.34681161
38Delayed CNS myelination (HP:0002188)3.13863246
39Pancreatic cysts (HP:0001737)3.11488277
40Steatorrhea (HP:0002570)3.09377450
41Abnormality of serum amino acid levels (HP:0003112)3.07524474
42Abnormality of nucleobase metabolism (HP:0010932)3.07156655
43Ketoacidosis (HP:0001993)3.01694541
44Hypochromic microcytic anemia (HP:0004840)3.00655417
45Hepatocellular carcinoma (HP:0001402)2.99497219
46Spontaneous abortion (HP:0005268)2.98774294
47Myocardial infarction (HP:0001658)2.87800076
48Pancreatic fibrosis (HP:0100732)2.84268977
49Generalized hypopigmentation of hair (HP:0011358)2.83952264
50Abnormality of the renal cortex (HP:0011035)2.83113838
51True hermaphroditism (HP:0010459)2.82441117
52Metabolic acidosis (HP:0001942)2.77694399
53Skin nodule (HP:0200036)2.74337220
54Abnormal biliary tract physiology (HP:0012439)2.72330910
55Bile duct proliferation (HP:0001408)2.72330910
56Congenital stationary night blindness (HP:0007642)2.69808528
57Abnormality of purine metabolism (HP:0004352)2.69361820
58Systemic lupus erythematosus (HP:0002725)2.63238266
59Abnormality of dicarboxylic acid metabolism (HP:0010995)2.62271355
60Dicarboxylic aciduria (HP:0003215)2.62271355
61Lethargy (HP:0001254)2.61867428
62Vascular calcification (HP:0004934)2.59319583
63Gaze-evoked nystagmus (HP:0000640)2.59055614
64Chronic hepatic failure (HP:0100626)2.57384047
65Acanthocytosis (HP:0001927)2.55638337
66Hypoglycemic seizures (HP:0002173)2.51015067
67Abnormal gallbladder morphology (HP:0012437)2.51007442
68Glomerulonephritis (HP:0000099)2.49266938
69Hypothermia (HP:0002045)2.48574077
70Cholelithiasis (HP:0001081)2.44615051
71Spastic diplegia (HP:0001264)2.44203906
72Cerebral edema (HP:0002181)2.43405103
73Attenuation of retinal blood vessels (HP:0007843)2.42361940
74Mitral stenosis (HP:0001718)2.39682431
75Gout (HP:0001997)2.38802200
76Cholecystitis (HP:0001082)2.38298532
77Abnormal gallbladder physiology (HP:0012438)2.38298532
78Irritability (HP:0000737)2.34837274
79Neonatal onset (HP:0003623)2.31476695
80Molar tooth sign on MRI (HP:0002419)2.30665304
81Abnormality of midbrain morphology (HP:0002418)2.30665304
82Cardiovascular calcification (HP:0011915)2.29917137
83Amyloidosis (HP:0011034)2.29726635
84Malnutrition (HP:0004395)2.25788155
85Esophageal varix (HP:0002040)2.23644060
86Recurrent gram-negative bacterial infections (HP:0005420)2.22540220
87Gingival bleeding (HP:0000225)2.20847828
88Arthropathy (HP:0003040)2.20546327
89Menorrhagia (HP:0000132)2.20466511
90Thyroid-stimulating hormone excess (HP:0002925)2.19480798
91Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.17105615
92Abnormality of alanine metabolism (HP:0010916)2.17105615
93Hyperalaninemia (HP:0003348)2.17105615
94Glycosuria (HP:0003076)2.14016091
95Abnormality of urine glucose concentration (HP:0011016)2.14016091
96Pancreatitis (HP:0001733)2.13707718
97Nephronophthisis (HP:0000090)2.13600954
98Late onset (HP:0003584)2.11533727
99Progressive cerebellar ataxia (HP:0002073)2.11298879
100Sensorimotor neuropathy (HP:0007141)2.10173874
101Reduced antithrombin III activity (HP:0001976)2.10095089
102Thrombophlebitis (HP:0004418)2.09407673
103Enlarged kidneys (HP:0000105)2.09231297
104Congenital sensorineural hearing impairment (HP:0008527)2.09137941
105Brushfield spots (HP:0001088)2.08888445
106Generalized aminoaciduria (HP:0002909)2.07463453
107Cystic liver disease (HP:0006706)2.06849555
108Vomiting (HP:0002013)2.06217304
109Abnormality of the renal medulla (HP:0100957)2.06026882
110Poikilocytosis (HP:0004447)2.05069547
111Opisthotonus (HP:0002179)2.04552235
112Blue irides (HP:0000635)2.03843666
113Hyperinsulinemic hypoglycemia (HP:0000825)2.02677071
114Abnormality of the gallbladder (HP:0005264)2.01656888
115Hemorrhage of the eye (HP:0011885)2.01653305
116Medial flaring of the eyebrow (HP:0010747)2.00702100
117Proximal tubulopathy (HP:0000114)2.00531534
118Abolished electroretinogram (ERG) (HP:0000550)2.00238053
119Dyskinesia (HP:0100660)1.97824441
120Bony spicule pigmentary retinopathy (HP:0007737)1.97065850
121Abnormal rod and cone electroretinograms (HP:0008323)1.94226918
122Rickets (HP:0002748)1.92894735
123Genetic anticipation (HP:0003743)1.92510097
124Osteomalacia (HP:0002749)1.92058696
125Abnormality of iron homeostasis (HP:0011031)1.89764701
126Decreased central vision (HP:0007663)1.88550069
127Renal cortical cysts (HP:0000803)1.88455406
128Increased corneal curvature (HP:0100692)1.87459188
129Keratoconus (HP:0000563)1.87459188
130Abnormal cartilage morphology (HP:0002763)1.87237198
131Aplasia/Hypoplasia of the fovea (HP:0008060)1.86811021
132Hypoplasia of the fovea (HP:0007750)1.86811021
133Abnormality of transition element cation homeostasis (HP:0011030)1.86783724
134Congenital hepatic fibrosis (HP:0002612)1.85608909
135Hypophosphatemic rickets (HP:0004912)1.85551918
136Hydroxyprolinuria (HP:0003080)1.84821651
137Abnormality of proline metabolism (HP:0010907)1.84821651
138Severe visual impairment (HP:0001141)1.82942274
139Intestinal atresia (HP:0011100)1.80237645
140Elevated hepatic transaminases (HP:0002910)1.80046472
141Abnormal enzyme/coenzyme activity (HP:0012379)1.79974169
142Facial shape deformation (HP:0011334)1.79897435
143Potter facies (HP:0002009)1.79897435
144Alkalosis (HP:0001948)1.78739668
145Abnormality of vitamin metabolism (HP:0100508)1.77893964
146Status epilepticus (HP:0002133)1.77812118
147Aplasia/Hypoplasia of the tongue (HP:0010295)1.77370162
148Sclerocornea (HP:0000647)1.77015821
149Nephritis (HP:0000123)1.76303316
150Reticulocytosis (HP:0001923)1.75034334
151Decreased electroretinogram (ERG) amplitude (HP:0000654)1.71821156
152Focal seizures (HP:0007359)1.71262850
153Absent speech (HP:0001344)1.70539653
154Febrile seizures (HP:0002373)1.68765836

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.33688587
2SIK14.62725614
3FGFR44.55827859
4ERN14.28622783
5MAP4K23.24382607
6TAOK33.01302533
7INSRR2.85266441
8ERBB42.77646518
9ADRBK22.77367116
10BMPR1B2.52014490
11PKN22.45182712
12NUAK12.43850314
13WNK32.39005692
14TRIM282.35858407
15ACVR1B2.35276272
16MAP2K42.35042270
17MST1R2.21549421
18FLT32.05038007
19CASK2.03644504
20MAPK132.00184177
21PIK3CG1.89394648
22MAPK111.82912521
23TRIB31.79114151
24TYK21.72721506
25ZAK1.62513321
26EIF2AK31.60810739
27LATS11.57241709
28OXSR11.56157664
29DAPK21.55482807
30MAP3K41.54884785
31ABL21.50556236
32PTK61.50154886
33MKNK21.48420034
34NEK91.41786879
35KDR1.36164227
36FRK1.34462654
37FGFR21.31533306
38BCR1.27862222
39BRSK21.27697213
40PAK31.24571694
41JAK21.22307812
42CAMKK21.21307102
43NTRK31.16200832
44MAP2K31.15937936
45STK391.14186576
46MAP3K71.12812644
47PINK11.12197664
48NEK11.12167123
49PRKCE1.11195755
50PRKAA21.09491958
51STK38L1.07889346
52GRK61.07859014
53ERBB31.06665050
54PDK21.05960938
55TNK21.05696479
56TBK11.02106434
57JAK11.00756812
58MAPK40.99948745
59ERBB20.99219473
60MAP3K140.98711350
61AKT30.97396291
62FER0.95378440
63MAP3K100.95169628
64PRKCZ0.92346907
65MARK10.92224174
66WNK40.91492657
67ADRBK10.91346435
68TNIK0.91070280
69MAP3K30.89783647
70MUSK0.89256655
71CDK60.88566158
72MET0.87621003
73MAP3K110.83840030
74PLK20.81679756
75CAMK1G0.80936758
76MAP2K60.78796159
77EPHB10.78399236
78TIE10.78373174
79MAPK120.78173312
80PRKACG0.77155028
81MAPK150.75648074
82MKNK10.75209363
83MAP2K70.74924721
84PTK2B0.73971988
85CSK0.71455672
86RIPK10.71333960
87EPHA30.70151749
88IRAK30.69818898
89CAMK2G0.69758650
90WEE10.69122105
91BLK0.68610259
92PLK40.67957913
93SIK30.67022516
94GSK3A0.66930116
95DYRK1B0.65569051
96CAMK1D0.65366602
97PRKAA10.64073507
98TGFBR20.61792587
99TRPM70.60668381
100SGK30.58316690
101TEC0.56191564
102CSF1R0.55130493
103TGFBR10.54784275
104PTK20.54765060
105PRKG10.54671420
106PNCK0.54265861
107MAPK70.54170513
108IKBKE0.54058379
109EPHA40.53637459
110TAOK20.53539353
111PRKCQ0.52827247
112STK30.52248400
113PRKACA0.51218226
114CSNK1D0.50949622
115FGFR30.50249752
116CAMK2A0.50045885
117PDPK10.49197028
118CSNK1G10.48049122
119CSNK1A10.46760055
120CDK40.46274348
121DYRK20.45142196
122GRK10.45043026
123CSNK1A1L0.44490231
124MARK30.44307334
125PBK0.44137904
126CDK30.43724612
127IGF1R0.43050523
128MAP3K50.42885456
129MAP3K130.42617588
130RET0.42365882
131MAP2K10.42220863
132SGK20.42070197
133MST40.41424573
134PRKCG0.40060199
135PRKACB0.39221013
136NLK0.37347994
137PRKCB0.36487379
138MAP3K60.35483940
139PKN10.34674563
140OBSCN0.33315737
141TXK0.32943975
142ICK0.32605689
143MAPKAPK50.31659637
144PDK10.31180715
145EGFR0.31073405
146MTOR0.30511521
147ATM0.29655368
148CAMK40.29605243
149SGK2230.29265892
150SGK4940.29265892
151CSNK1G20.29062089
152CAMK10.28139705
153IRAK20.28125126
154CSNK1G30.27107378
155PRKCI0.26995895
156PRKCA0.26076707
157LATS20.24565205
158IRAK10.24066225
159MAP3K10.22226544
160PDK30.22186432
161PDK40.22186432
162MAP2K20.20736649
163PIK3CA0.20501173
164ABL10.20197177
165BMX0.18446148

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.48986125
2Nitrogen metabolism_Homo sapiens_hsa009103.62373571
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.40514910
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.39221166
5Arginine biosynthesis_Homo sapiens_hsa002203.04485160
6Complement and coagulation cascades_Homo sapiens_hsa046102.75898355
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.72470211
8Tryptophan metabolism_Homo sapiens_hsa003802.66862811
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.64491870
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.52905349
11Fatty acid degradation_Homo sapiens_hsa000712.47346332
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37820514
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.27381432
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.18042216
15Butanoate metabolism_Homo sapiens_hsa006502.14774668
16Peroxisome_Homo sapiens_hsa041462.06285319
17Chemical carcinogenesis_Homo sapiens_hsa052041.99691222
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.97584951
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.95766629
20Propanoate metabolism_Homo sapiens_hsa006401.93034094
21Histidine metabolism_Homo sapiens_hsa003401.88252440
22PPAR signaling pathway_Homo sapiens_hsa033201.85711335
23Fatty acid metabolism_Homo sapiens_hsa012121.80840511
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.79592879
25Staphylococcus aureus infection_Homo sapiens_hsa051501.76801675
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.73595448
27Caffeine metabolism_Homo sapiens_hsa002321.73548416
28Retinol metabolism_Homo sapiens_hsa008301.71919576
29beta-Alanine metabolism_Homo sapiens_hsa004101.70642972
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.65402041
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64994509
32Selenocompound metabolism_Homo sapiens_hsa004501.57863406
33Phenylalanine metabolism_Homo sapiens_hsa003601.56837564
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52375927
35Bile secretion_Homo sapiens_hsa049761.50712087
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47963166
37Tyrosine metabolism_Homo sapiens_hsa003501.44196759
38Sulfur metabolism_Homo sapiens_hsa009201.37139296
39Pyruvate metabolism_Homo sapiens_hsa006201.35563627
40Fatty acid elongation_Homo sapiens_hsa000621.34509372
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.30826891
42Starch and sucrose metabolism_Homo sapiens_hsa005001.28180439
43Folate biosynthesis_Homo sapiens_hsa007901.24705596
44ABC transporters_Homo sapiens_hsa020101.19094550
45Biosynthesis of amino acids_Homo sapiens_hsa012301.18858448
46Steroid biosynthesis_Homo sapiens_hsa001001.18696817
47Fat digestion and absorption_Homo sapiens_hsa049751.17322093
48Carbon metabolism_Homo sapiens_hsa012001.12882022
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00833845
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00087548
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.98887422
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.98381999
53Phototransduction_Homo sapiens_hsa047440.97521258
54Arginine and proline metabolism_Homo sapiens_hsa003300.97381876
55Sulfur relay system_Homo sapiens_hsa041220.97072924
56Vitamin B6 metabolism_Homo sapiens_hsa007500.89662436
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87913168
58Vitamin digestion and absorption_Homo sapiens_hsa049770.85837970
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82195552
60Lysine degradation_Homo sapiens_hsa003100.79411020
61One carbon pool by folate_Homo sapiens_hsa006700.76451337
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75017745
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70099446
64Glycerolipid metabolism_Homo sapiens_hsa005610.66790599
65Glutathione metabolism_Homo sapiens_hsa004800.65971242
66Homologous recombination_Homo sapiens_hsa034400.65225187
67Pentose phosphate pathway_Homo sapiens_hsa000300.58924893
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57868632
69Fatty acid biosynthesis_Homo sapiens_hsa000610.52757594
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51544352
71Serotonergic synapse_Homo sapiens_hsa047260.48544656
72Nicotine addiction_Homo sapiens_hsa050330.46687182
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46446009
74Metabolic pathways_Homo sapiens_hsa011000.46277699
75Protein export_Homo sapiens_hsa030600.45364126
76Fanconi anemia pathway_Homo sapiens_hsa034600.41848578
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40891745
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38591276
79Taste transduction_Homo sapiens_hsa047420.38019606
80Olfactory transduction_Homo sapiens_hsa047400.34494805
81Prion diseases_Homo sapiens_hsa050200.31644439
82GABAergic synapse_Homo sapiens_hsa047270.28421384
83Galactose metabolism_Homo sapiens_hsa000520.25477722
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25433713
85Linoleic acid metabolism_Homo sapiens_hsa005910.23860809
86Mineral absorption_Homo sapiens_hsa049780.23705036
87Fructose and mannose metabolism_Homo sapiens_hsa000510.23261497
88Insulin resistance_Homo sapiens_hsa049310.21544928
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.20361396
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19882502
91Glutamatergic synapse_Homo sapiens_hsa047240.15867143
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.14862086
93Morphine addiction_Homo sapiens_hsa050320.14337119
94Sphingolipid metabolism_Homo sapiens_hsa006000.12579490
95Glucagon signaling pathway_Homo sapiens_hsa049220.08607963
96Circadian rhythm_Homo sapiens_hsa047100.08505647
97Basal transcription factors_Homo sapiens_hsa030220.08420539
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.05197099
99Pertussis_Homo sapiens_hsa051330.03195637
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.03194375
101Insulin secretion_Homo sapiens_hsa049110.02095057
102AMPK signaling pathway_Homo sapiens_hsa041520.00880773
103Non-homologous end-joining_Homo sapiens_hsa034500.00536197
104Bladder cancer_Homo sapiens_hsa05219-0.2538321
105Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2525396
106Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2475862
107Ether lipid metabolism_Homo sapiens_hsa00565-0.2424533
108Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2325311
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2058178
110Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1955781
111Renin-angiotensin system_Homo sapiens_hsa04614-0.1927503
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1926127
113Hepatitis C_Homo sapiens_hsa05160-0.1872060
114Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1629161
115Regulation of autophagy_Homo sapiens_hsa04140-0.1623871
116Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1607297
117Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1587745
118Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1529293
119African trypanosomiasis_Homo sapiens_hsa05143-0.1330052
120Insulin signaling pathway_Homo sapiens_hsa04910-0.1123483
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0922018
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0767664
123Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0754198
124Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0263123

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