LEF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)6.69634532
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.64501598
3negative regulation of cell killing (GO:0031342)6.64501598
4negative thymic T cell selection (GO:0045060)6.14678583
5positive regulation of gamma-delta T cell activation (GO:0046645)6.13719790
6positive T cell selection (GO:0043368)5.90627329
7positive thymic T cell selection (GO:0045059)5.54273152
8regulation of gamma-delta T cell differentiation (GO:0045586)5.29431774
9interferon-gamma production (GO:0032609)5.24465697
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.18379773
11thymic T cell selection (GO:0045061)5.18198737
12Peyers patch development (GO:0048541)5.15064790
13mucosal-associated lymphoid tissue development (GO:0048537)5.15064790
14T cell selection (GO:0045058)5.14139485
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.06228158
16regulation of gamma-delta T cell activation (GO:0046643)4.88778039
17cellular response to interleukin-15 (GO:0071350)4.75460546
18* positive regulation of granulocyte differentiation (GO:0030854)4.73270190
19response to interleukin-15 (GO:0070672)4.51363395
20T cell receptor signaling pathway (GO:0050852)4.38676911
21positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.32259181
22regulation of T cell tolerance induction (GO:0002664)4.23569093
23* V(D)J recombination (GO:0033151)4.22997372
24regulation of isotype switching to IgG isotypes (GO:0048302)4.06514752
25B cell receptor signaling pathway (GO:0050853)3.89226971
26histone H3-K36 demethylation (GO:0070544)3.76308757
27T cell migration (GO:0072678)3.71133991
28natural killer cell differentiation (GO:0001779)3.70327440
29T cell costimulation (GO:0031295)3.64769837
30regulation of B cell differentiation (GO:0045577)3.63987406
31positive regulation of B cell differentiation (GO:0045579)3.63365730
32leukocyte aggregation (GO:0070486)3.57459358
33regulation of T cell receptor signaling pathway (GO:0050856)3.57034661
34lymphocyte costimulation (GO:0031294)3.57029900
35negative regulation of T cell apoptotic process (GO:0070233)3.55579440
36antigen receptor-mediated signaling pathway (GO:0050851)3.54769768
37* T cell differentiation (GO:0030217)3.38135671
38positive regulation of tolerance induction (GO:0002645)3.37506426
39positive regulation of alpha-beta T cell activation (GO:0046635)3.34288544
40regulation of alpha-beta T cell activation (GO:0046634)3.27525599
41regulation of alpha-beta T cell proliferation (GO:0046640)3.24209705
42negative regulation of erythrocyte differentiation (GO:0045647)3.23964017
43regulation of interleukin-2 biosynthetic process (GO:0045076)3.23882677
44antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.20615456
45antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.20615456
46regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.19993821
47negative regulation of T cell mediated immunity (GO:0002710)3.19936800
48* regulation of granulocyte differentiation (GO:0030852)3.19831543
49activated T cell proliferation (GO:0050798)3.12876167
50mast cell degranulation (GO:0043303)3.12720328
51mast cell activation involved in immune response (GO:0002279)3.12720328
52negative regulation of leukocyte mediated immunity (GO:0002704)3.07954352
53regulation of histone H3-K27 methylation (GO:0061085)3.06802371
54positive regulation of interleukin-2 production (GO:0032743)3.04521341
55regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.03803496
56negative regulation of myotube differentiation (GO:0010832)3.01779537
57positive regulation of alpha-beta T cell differentiation (GO:0046638)3.00672339
58positive regulation of interleukin-4 production (GO:0032753)2.98022664
59positive regulation of isotype switching (GO:0045830)2.96569287
60positive regulation of alpha-beta T cell proliferation (GO:0046641)2.96248383
61positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.95268077
62regulation of B cell receptor signaling pathway (GO:0050855)2.93473580
63regulation of alpha-beta T cell differentiation (GO:0046637)2.90525893
64regulation of tolerance induction (GO:0002643)2.90367387
65mitotic sister chromatid cohesion (GO:0007064)2.89088252
66negative regulation of phagocytosis (GO:0050765)2.85794727
67positive regulation of keratinocyte differentiation (GO:0045618)2.80911105
68negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.80604974
69hepatocyte apoptotic process (GO:0097284)2.80074490
70* T cell activation (GO:0042110)2.79178707
71regulation of defense response to virus by virus (GO:0050690)2.78994727
72signal complex assembly (GO:0007172)2.78066869
73negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.77801283
74histone H4-K16 acetylation (GO:0043984)2.76798513
75antigen processing and presentation via MHC class Ib (GO:0002475)2.75832636
76nuclear pore complex assembly (GO:0051292)2.75738735
77* cellular response to interleukin-4 (GO:0071353)2.74998843
78response to muramyl dipeptide (GO:0032495)2.74756727
79positive regulation of T cell differentiation (GO:0045582)2.74751098
80cellular extravasation (GO:0045123)2.74319792
81lymph node development (GO:0048535)2.72242228
82endothelial tube morphogenesis (GO:0061154)2.72208242
83morphogenesis of an endothelium (GO:0003159)2.72208242
84histone H3-K4 trimethylation (GO:0080182)2.71345719
85* alpha-beta T cell differentiation (GO:0046632)2.69461698
86lymphocyte migration (GO:0072676)2.67471980
87* alpha-beta T cell activation (GO:0046631)2.67437564
88ribosomal small subunit assembly (GO:0000028)2.66919796
89epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.66470757
90mast cell activation (GO:0045576)2.65893048
91positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.65801437
92positive regulation of natural killer cell mediated immunity (GO:0002717)2.63224747
93positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.63224747
94* somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.61589577
95* somatic cell DNA recombination (GO:0016444)2.61589577
96positive regulation of DNA recombination (GO:0045911)2.61441060
97positive regulation of humoral immune response (GO:0002922)2.58366986
98regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.57786599
99regulation of regulatory T cell differentiation (GO:0045589)2.56934352
100regulation of isotype switching (GO:0045191)2.55986386
101regulation of response to interferon-gamma (GO:0060330)2.54109492
102tolerance induction (GO:0002507)2.53658240
103regulation of natural killer cell mediated immunity (GO:0002715)2.52849086
104regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.52849086
105T cell homeostasis (GO:0043029)2.51798396
106antigen processing and presentation of endogenous antigen (GO:0019883)2.50440490
107positive regulation of B cell mediated immunity (GO:0002714)2.48535299
108positive regulation of immunoglobulin mediated immune response (GO:0002891)2.48535299
109positive regulation of T cell differentiation in thymus (GO:0033089)2.46869636
110nuclear pore organization (GO:0006999)2.46618568
111* somatic diversification of immune receptors (GO:0002200)2.46466441
112sequestering of actin monomers (GO:0042989)2.44385477
113negative regulation of T cell receptor signaling pathway (GO:0050860)2.41150605
114negative regulation of thymocyte apoptotic process (GO:0070244)2.41111238
115positive regulation of interleukin-8 secretion (GO:2000484)2.36466275
116natural killer cell activation (GO:0030101)2.36093255
117viral transcription (GO:0019083)2.35808298
118DNA unwinding involved in DNA replication (GO:0006268)2.35084518
119regulation of interleukin-12 biosynthetic process (GO:0045075)2.34823944
120mitotic chromosome condensation (GO:0007076)2.34666750
121negative regulation of lymphocyte mediated immunity (GO:0002707)2.32757983
122immune response-activating cell surface receptor signaling pathway (GO:0002429)2.32231783
123kinetochore organization (GO:0051383)2.31922137
124T cell lineage commitment (GO:0002360)2.31453415
125regulation of leukocyte mediated cytotoxicity (GO:0001910)2.30557717
126regulation of thymocyte apoptotic process (GO:0070243)2.29886144
127histone H3-K4 methylation (GO:0051568)2.29692122
128maturation of SSU-rRNA (GO:0030490)2.29590865
129NIK/NF-kappaB signaling (GO:0038061)2.28778635
130* lymphocyte differentiation (GO:0030098)2.28730494
131alternative mRNA splicing, via spliceosome (GO:0000380)2.26997542
132regulation of immunoglobulin mediated immune response (GO:0002889)2.26769048
133regulation of interleukin-2 production (GO:0032663)2.26333368
134ribosomal small subunit biogenesis (GO:0042274)2.25405497
135translational termination (GO:0006415)2.24753179
136positive regulation of immunoglobulin production (GO:0002639)2.23822238
137lymphocyte homeostasis (GO:0002260)2.22926401
138mitotic nuclear envelope disassembly (GO:0007077)2.22476024

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.06413149
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.00010070
3* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.26081478
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.88155726
5* MYC_22102868_ChIP-Seq_BL_Human3.63950956
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.56962666
7* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.36795015
8* RUNX_20019798_ChIP-Seq_JUKART_Human3.19273840
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.16204448
10* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.10675324
11* TP63_19390658_ChIP-ChIP_HaCaT_Human2.95059823
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.89322309
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.89075069
14MYB_26560356_Chip-Seq_TH2_Human2.85512872
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.75975290
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.66431950
17* UTX_26944678_Chip-Seq_JUKART_Human2.43803789
18MYB_26560356_Chip-Seq_TH1_Human2.39114407
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.38608976
20MAF_26560356_Chip-Seq_TH1_Human2.33501307
21* IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.24800570
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.11679846
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.06380905
24CIITA_25753668_ChIP-Seq_RAJI_Human1.96660266
25IRF8_22096565_ChIP-ChIP_GC-B_Human1.94378284
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.91730557
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.91438897
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.85575686
29MYC_18555785_ChIP-Seq_MESCs_Mouse1.79443439
30MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.74147006
31* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.70198226
32MAF_26560356_Chip-Seq_TH2_Human1.69461230
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.66342743
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.66196486
35VDR_21846776_ChIP-Seq_THP-1_Human1.66182763
36FOXP3_21729870_ChIP-Seq_TREG_Human1.61408282
37VDR_23849224_ChIP-Seq_CD4+_Human1.61291421
38IRF8_27001747_Chip-Seq_BMDM_Mouse1.60743320
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.59249671
40* TCF7_22412390_ChIP-Seq_EML_Mouse1.56597172
41GATA3_27048872_Chip-Seq_THYMUS_Human1.55808965
42TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52678714
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.48410068
44TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.48104567
45EST1_17652178_ChIP-ChIP_JURKAT_Human1.43816571
46* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.42341209
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41706634
48ELK1_19687146_ChIP-ChIP_HELA_Human1.38613001
49SPI1_23547873_ChIP-Seq_NB4_Human1.37274436
50BP1_19119308_ChIP-ChIP_Hs578T_Human1.35482897
51SCL_19346495_ChIP-Seq_HPC-7_Human1.34679461
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.31542757
53* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.30845645
54* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.29404670
55XRN2_22483619_ChIP-Seq_HELA_Human1.29053145
56BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27925150
57DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.27013795
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22735911
59EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.22517464
60* RUNX1_22412390_ChIP-Seq_EML_Mouse1.20836813
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16994707
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.16912317
63* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15779030
64VDR_24763502_ChIP-Seq_THP-1_Human1.14735436
65RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.12641390
66E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.12509405
67* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12246082
68SMAD_19615063_ChIP-ChIP_OVARY_Human1.11538025
69NELFA_20434984_ChIP-Seq_ESCs_Mouse1.11457912
70* KDM2B_26808549_Chip-Seq_DND41_Human1.10290218
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09073402
72SALL1_21062744_ChIP-ChIP_HESCs_Human1.08219591
73TTF2_22483619_ChIP-Seq_HELA_Human1.06150926
74HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04334633
75GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04017983
76PU_27001747_Chip-Seq_BMDM_Mouse1.02687818
77GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99702044
78KDM5A_27292631_Chip-Seq_BREAST_Human0.98987497
79GABP_17652178_ChIP-ChIP_JURKAT_Human0.98202430
80GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97986715
81ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96300532
82PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96289288
83NCOR1_26117541_ChIP-Seq_K562_Human0.94300085
84MYC_18358816_ChIP-ChIP_MESCs_Mouse0.93161560
85VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92854154
86FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.92520752
87* KDM2B_26808549_Chip-Seq_JURKAT_Human0.91281305
88MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.90103292
89MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.89939386
90CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.89726666
91PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89354922
92GATA1_19941827_ChIP-Seq_MEL_Mouse0.89027675
93* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88091681
94VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.87749512
95FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.86192947
96RBPJ_22232070_ChIP-Seq_NCS_Mouse0.86007867
97MYC_18940864_ChIP-ChIP_HL60_Human0.85644574
98GATA2_22383799_ChIP-Seq_G1ME_Mouse0.82135544
99VDR_24787735_ChIP-Seq_THP-1_Human0.81327039
100PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81301140
101MYB_21317192_ChIP-Seq_ERMYB_Mouse0.81183913
102IRF1_19129219_ChIP-ChIP_H3396_Human0.80992993
103E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.79864589
104CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79690247
105PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78652176
106* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77770320
107FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77618748
108CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.76924227
109ETS1_20019798_ChIP-Seq_JURKAT_Human0.76826479
110PKCTHETA_26484144_Chip-Seq_BREAST_Human0.76494481
111PADI4_21655091_ChIP-ChIP_MCF-7_Human0.76256169
112* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.75929051
113AR_21909140_ChIP-Seq_LNCAP_Human0.75883926
114GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75087508
115ETS1_22383799_ChIP-Seq_G1ME_Mouse0.74712968
116NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.74574783
117MYCN_18555785_ChIP-Seq_MESCs_Mouse0.74381419
118GATA3_26560356_Chip-Seq_TH1_Human0.74178539
119CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73424481
120CTCF_21964334_ChIP-Seq_BJAB-B_Human0.72773488
121STAT6_21828071_ChIP-Seq_BEAS2B_Human0.72311650
122GATA3_26560356_Chip-Seq_TH2_Human0.72212834
123SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.71619536
124NANOG_18555785_ChIP-Seq_MESCs_Mouse0.71255723
125ELK3_25401928_ChIP-Seq_HUVEC_Human0.70577716
126SPI1_23127762_ChIP-Seq_K562_Human0.70357442
127IRF8_21731497_ChIP-ChIP_J774_Mouse0.70268534
128NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.69393616
129LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.69270569
130GATA1_22025678_ChIP-Seq_K562_Human0.68557002

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology5.54101199
2MP0005671_abnormal_response_to3.17870544
3MP0000703_abnormal_thymus_morphology2.95547054
4MP0010094_abnormal_chromosome_stability2.51224707
5MP0002398_abnormal_bone_marrow2.46776356
6MP0008057_abnormal_DNA_replication2.41795684
7MP0009333_abnormal_splenocyte_physiolog2.41730639
8MP0002396_abnormal_hematopoietic_system2.41620687
9MP0000685_abnormal_immune_system2.37862734
10* MP0004381_abnormal_hair_follicle2.37576487
11MP0003693_abnormal_embryo_hatching2.26691618
12MP0001800_abnormal_humoral_immune2.22013158
13MP0002166_altered_tumor_susceptibility2.18828704
14MP0002722_abnormal_immune_system2.15016566
15MP0004808_abnormal_hematopoietic_stem2.14883403
16MP0003077_abnormal_cell_cycle2.13058208
17MP0002405_respiratory_system_inflammati2.04512207
18MP0002420_abnormal_adaptive_immunity2.02838381
19MP0001819_abnormal_immune_cell1.99450028
20MP0003111_abnormal_nucleus_morphology1.95869211
21MP0000716_abnormal_immune_system1.95780587
22MP0000689_abnormal_spleen_morphology1.94715197
23MP0002006_tumorigenesis1.88541740
24MP0008007_abnormal_cellular_replicative1.83623482
25MP0004957_abnormal_blastocyst_morpholog1.83477367
26MP0005387_immune_system_phenotype1.82755426
27MP0001790_abnormal_immune_system1.82755426
28MP0002723_abnormal_immune_serum1.81813863
29MP0001873_stomach_inflammation1.81176500
30MP0003303_peritoneal_inflammation1.75682943
31MP0002452_abnormal_antigen_presenting1.75506366
32MP0008058_abnormal_DNA_repair1.74825312
33MP0008877_abnormal_DNA_methylation1.69913059
34MP0005000_abnormal_immune_tolerance1.67999526
35MP0009278_abnormal_bone_marrow1.67552188
36MP0002009_preneoplasia1.66962385
37MP0002429_abnormal_blood_cell1.63041735
38MP0001835_abnormal_antigen_presentation1.54565082
39MP0005310_abnormal_salivary_gland1.51847320
40MP0009785_altered_susceptibility_to1.33577098
41MP0010155_abnormal_intestine_physiology1.31967819
42MP0002132_abnormal_respiratory_system1.30581643
43MP0008260_abnormal_autophagy1.28910595
44MP0001545_abnormal_hematopoietic_system1.28065202
45MP0005397_hematopoietic_system_phenotyp1.28065202
46MP0002933_joint_inflammation1.27036534
47MP0000490_abnormal_crypts_of1.25588013
48MP0003724_increased_susceptibility_to1.25134031
49MP0003787_abnormal_imprinting1.24486533
50MP0000566_synostosis1.24307788
51MP0005464_abnormal_platelet_physiology1.22293251
52MP0000465_gastrointestinal_hemorrhage1.21974451
53MP0002019_abnormal_tumor_incidence1.19072264
54MP0005025_abnormal_response_to1.18847231
55MP0001851_eye_inflammation1.17445248
56MP0000350_abnormal_cell_proliferation1.16571439
57MP0004947_skin_inflammation1.16269204
58MP0003890_abnormal_embryonic-extraembry1.15588436
59MP0005409_darkened_coat_color1.14256829
60MP0005451_abnormal_body_composition1.13023653
61* MP0005075_abnormal_melanosome_morpholog1.12684344
62MP0001730_embryonic_growth_arrest1.12456499
63MP0003121_genomic_imprinting1.09055968
64MP0010030_abnormal_orbit_morphology1.08854354
65MP0000858_altered_metastatic_potential1.08233149
66MP0005380_embryogenesis_phenotype1.08085909
67MP0001672_abnormal_embryogenesis/_devel1.08085909
68MP0002088_abnormal_embryonic_growth/wei1.04528299
69MP0003984_embryonic_growth_retardation1.04199016
70MP0003436_decreased_susceptibility_to1.03701585
71MP0003943_abnormal_hepatobiliary_system1.03324912
72MP0003300_gastrointestinal_ulcer1.01729556
73MP0003172_abnormal_lysosome_physiology1.01026999
74MP0008961_abnormal_basal_metabolism0.99939300
75MP0002085_abnormal_embryonic_tissue0.97711974
76MP0001919_abnormal_reproductive_system0.97105765
77MP0008932_abnormal_embryonic_tissue0.95465250
78MP0003866_abnormal_defecation0.95433652
79MP0002084_abnormal_developmental_patter0.92795259
80MP0001697_abnormal_embryo_size0.92064225
81MP0001533_abnormal_skeleton_physiology0.91904898
82MP0002938_white_spotting0.91680832
83MP0003786_premature_aging0.90901475
84MP0010352_gastrointestinal_tract_polyps0.89847627
85MP0002086_abnormal_extraembryonic_tissu0.88963176
86MP0006082_CNS_inflammation0.87093607
87MP0001293_anophthalmia0.87050638
88MP0000383_abnormal_hair_follicle0.84983885
89MP0005076_abnormal_cell_differentiation0.84886810
90MP0004185_abnormal_adipocyte_glucose0.82218686
91MP0000313_abnormal_cell_death0.80523663
92MP0001853_heart_inflammation0.80135710
93MP0006292_abnormal_olfactory_placode0.79340855
94MP0006054_spinal_hemorrhage0.79100696
95MP0002932_abnormal_joint_morphology0.78171344
96MP0001845_abnormal_inflammatory_respons0.77589554
97MP0000015_abnormal_ear_pigmentation0.77503650
98MP0003828_pulmonary_edema0.77312799
99MP0002163_abnormal_gland_morphology0.77193782
100MP0003448_altered_tumor_morphology0.74731023
101* MP0003935_abnormal_craniofacial_develop0.74503469
102MP0001119_abnormal_female_reproductive0.72552429
103MP0001663_abnormal_digestive_system0.71383357
104MP0010307_abnormal_tumor_latency0.71337668
105MP0008469_abnormal_protein_level0.71015320
106MP0002080_prenatal_lethality0.70608165
107MP0004130_abnormal_muscle_cell0.70263806
108* MP0002925_abnormal_cardiovascular_devel0.70039529
109MP0000428_abnormal_craniofacial_morphol0.69305955
110MP0002102_abnormal_ear_morphology0.68598442
111MP0002148_abnormal_hypersensitivity_rea0.67938282
112MP0002127_abnormal_cardiovascular_syste0.67363696
113MP0005389_reproductive_system_phenotype0.66381253
114MP0002419_abnormal_innate_immunity0.66269798
115MP0004197_abnormal_fetal_growth/weight/0.66057925
116MP0002138_abnormal_hepatobiliary_system0.64736833
117MP0000613_abnormal_salivary_gland0.64637886
118MP0002998_abnormal_bone_remodeling0.64473970
119* MP0000432_abnormal_head_morphology0.64451799
120MP0008995_early_reproductive_senescence0.63802278
121MP0002277_abnormal_respiratory_mucosa0.56657548
122MP0009763_increased_sensitivity_to0.54843119
123MP0009115_abnormal_fat_cell0.53386857
124MP0000372_irregular_coat_pigmentation0.53275007
125MP0004883_abnormal_blood_vessel0.50781240
126MP0005621_abnormal_cell_physiology0.48003061
127MP0002083_premature_death0.44571122
128MP0001849_ear_inflammation0.43373421
129MP0000477_abnormal_intestine_morphology0.42269334
130MP0003221_abnormal_cardiomyocyte_apopto0.40617406
131MP0001348_abnormal_lacrimal_gland0.40588075

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)6.98899125
2Abnormality of T cell number (HP:0011839)6.64495601
3Severe combined immunodeficiency (HP:0004430)5.77934128
4Combined immunodeficiency (HP:0005387)5.37557568
5Eczematoid dermatitis (HP:0000976)4.82615579
6Thyroiditis (HP:0100646)4.40316512
7Abnormality of T cells (HP:0002843)4.13735040
8Abnormality of the fingertips (HP:0001211)4.03457882
9Panhypogammaglobulinemia (HP:0003139)3.74378944
10Increased IgE level (HP:0003212)3.58770097
11Abnormality of eosinophils (HP:0001879)3.47905818
12B lymphocytopenia (HP:0010976)3.41535340
13Abnormality of B cell number (HP:0010975)3.41535340
14Short 4th metacarpal (HP:0010044)3.35219560
15Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.35219560
16IgG deficiency (HP:0004315)3.18701517
17Eosinophilia (HP:0001880)3.18366624
18Trigonocephaly (HP:0000243)3.14569870
19Recurrent viral infections (HP:0004429)3.09605119
20Encephalitis (HP:0002383)3.05368966
21Myositis (HP:0100614)3.03304697
22Recurrent bronchitis (HP:0002837)3.01397946
23Recurrent abscess formation (HP:0002722)2.93568653
24Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.91269005
25Abnormality of the parietal bone (HP:0002696)2.90124905
26Recurrent fungal infections (HP:0002841)2.87293694
27Papilledema (HP:0001085)2.85672508
28Recurrent bacterial skin infections (HP:0005406)2.82714674
29Gastrointestinal inflammation (HP:0004386)2.79271625
30Agammaglobulinemia (HP:0004432)2.78320854
31Inflammation of the large intestine (HP:0002037)2.69968606
32Gastrointestinal infarctions (HP:0005244)2.69450722
33Granulocytopenia (HP:0001913)2.68731941
34Leukocytosis (HP:0001974)2.68494228
35Slow saccadic eye movements (HP:0000514)2.66518268
36Elevated erythrocyte sedimentation rate (HP:0003565)2.61631446
37Abnormal number of incisors (HP:0011064)2.61449506
38Abnormality of the thymus (HP:0000777)2.59044487
39Colitis (HP:0002583)2.55276545
40Basal cell carcinoma (HP:0002671)2.54336583
41Chronic otitis media (HP:0000389)2.51146420
42Ectopic kidney (HP:0000086)2.47890183
43Vasculitis (HP:0002633)2.47654715
44Optic neuritis (HP:0100653)2.45519975
45Retrobulbar optic neuritis (HP:0100654)2.45519975
46Chronic mucocutaneous candidiasis (HP:0002728)2.45280161
47Recurrent cutaneous fungal infections (HP:0011370)2.45280161
48Hypoplasia of the thymus (HP:0000778)2.40060708
49Prolonged bleeding time (HP:0003010)2.35676186
50Hypoproteinemia (HP:0003075)2.34531933
51Chronic obstructive pulmonary disease (HP:0006510)2.33281945
52Obstructive lung disease (HP:0006536)2.33281945
53Sparse lateral eyebrow (HP:0005338)2.31658239
54Recurrent skin infections (HP:0001581)2.30316884
55Orchitis (HP:0100796)2.29969979
56Abnormality of macrophages (HP:0004311)2.29915389
57Stomatitis (HP:0010280)2.28065088
58IgM deficiency (HP:0002850)2.25825929
59Aplasia cutis congenita (HP:0001057)2.25071229
60Abnormality of the left ventricular outflow tract (HP:0011103)2.24904897
61Subaortic stenosis (HP:0001682)2.24904897
62Long eyelashes (HP:0000527)2.24654922
63Lymphoma (HP:0002665)2.19439834
64Lymphopenia (HP:0001888)2.18572383
65Abnormality of cells of the lymphoid lineage (HP:0012140)2.18203090
66Volvulus (HP:0002580)2.17312417
67Sepsis (HP:0100806)2.17282142
68Abnormality of the intervertebral disk (HP:0005108)2.13657843
69Chronic diarrhea (HP:0002028)2.13166467
70Cellulitis (HP:0100658)2.12306669
71Chest pain (HP:0100749)2.12041471
72Intestinal fistula (HP:0100819)2.12008652
73Acute lymphatic leukemia (HP:0006721)2.08622835
74Abnormality of the 4th metacarpal (HP:0010012)2.08576612
75Broad face (HP:0000283)2.08441740
76Medulloblastoma (HP:0002885)2.08068064
77Abnormal delayed hypersensitivity skin test (HP:0002963)2.08006542
78Increased IgM level (HP:0003496)2.06944043
79Supernumerary ribs (HP:0005815)2.05559544
80Meningitis (HP:0001287)2.04896801
81Optic nerve coloboma (HP:0000588)2.04696738
82Autoimmune hemolytic anemia (HP:0001890)2.04202507
83Keratoconjunctivitis sicca (HP:0001097)2.03151616
84Reticulocytopenia (HP:0001896)2.02471967
85Verrucae (HP:0200043)2.01859523
86Papilloma (HP:0012740)2.01859523
87Viral hepatitis (HP:0006562)2.01779523
88Midline defect of the nose (HP:0004122)1.99583039
89Recurrent otitis media (HP:0000403)1.99434988
90Chromsome breakage (HP:0040012)1.97457041
91Anal stenosis (HP:0002025)1.96317936
92Mesomelia (HP:0003027)1.95521273
93Autoimmune thrombocytopenia (HP:0001973)1.95429196
94Supernumerary bones of the axial skeleton (HP:0009144)1.93931236
95Nasal polyposis (HP:0100582)1.93854611
96Depressed nasal tip (HP:0000437)1.93591050
97Prominent nose (HP:0000448)1.92675767
98Chromosomal breakage induced by crosslinking agents (HP:0003221)1.92669052
99Cutis marmorata (HP:0000965)1.90423410
100Abnormality of the incisor (HP:0000676)1.90385618
101Subacute progressive viral hepatitis (HP:0006572)1.88618689
102Bronchitis (HP:0012387)1.88101033
103Hypergammaglobulinemia (HP:0010702)1.87846582
104Rib fusion (HP:0000902)1.86075648
105Deep palmar crease (HP:0006191)1.85864437
106Acute hepatic failure (HP:0006554)1.85443600
107Patellar aplasia (HP:0006443)1.84977829
108Meckel diverticulum (HP:0002245)1.84254789
109Pulmonary infiltrates (HP:0002113)1.83930331
110Epistaxis (HP:0000421)1.83168364
111Skull defect (HP:0001362)1.83161089
112Deep philtrum (HP:0002002)1.82107476
113Vertebral arch anomaly (HP:0008438)1.81892485
114Keratoconjunctivitis (HP:0001096)1.81589541
115Joint swelling (HP:0001386)1.81500601
116Proximal placement of thumb (HP:0009623)1.80660215
117Abnormality of the ileum (HP:0001549)1.79695793
118Dislocated radial head (HP:0003083)1.78712901
119Chronic sinusitis (HP:0011109)1.77045505
120Microcytic anemia (HP:0001935)1.75294384
121Bicuspid aortic valve (HP:0001647)1.75272481
122Hemoptysis (HP:0002105)1.75191017
123Gingivitis (HP:0000230)1.74652680
124Nephroblastoma (Wilms tumor) (HP:0002667)1.74306481
125Abnormality of chromosome stability (HP:0003220)1.74006677
126Hypochromic anemia (HP:0001931)1.73966906
127Abnormality of T cell physiology (HP:0011840)1.72452604
128Pulmonary embolism (HP:0002204)1.70999297
129Aplasia/Hypoplasia of the thymus (HP:0010515)1.70009004
130Abnormality of the radial head (HP:0003995)1.69209618
131Ureteral stenosis (HP:0000071)1.68761683
132Aplasia/Hypoplasia of the patella (HP:0006498)1.68597699
133Deviation of the thumb (HP:0009603)1.68360014
134Aplasia/Hypoplasia of the uvula (HP:0010293)1.68288017
135Teleangiectasia of the skin (HP:0100585)1.66704689
136IgA deficiency (HP:0002720)1.66547517
137Long palpebral fissure (HP:0000637)1.66117992
138Abnormality of the columella (HP:0009929)1.65863569
139Abnormality of abdominal situs (HP:0011620)1.64974070
140Abdominal situs inversus (HP:0003363)1.64974070
141Abnormality of the prostate (HP:0008775)1.64398917
142Amaurosis fugax (HP:0100576)1.64376583
143Sparse scalp hair (HP:0002209)1.63870035
144Somatic mutation (HP:0001428)1.63554001
145Recurrent gram-negative bacterial infections (HP:0005420)1.63406485
146Spontaneous hematomas (HP:0007420)1.62558762
147Cheilitis (HP:0100825)1.61632476
148Skin tags (HP:0010609)1.60986948
149Absent radius (HP:0003974)1.60221316
150Mediastinal lymphadenopathy (HP:0100721)1.59815194
151Pustule (HP:0200039)1.59500278
152Abnormality of the preputium (HP:0100587)1.59447761

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.40973677
2MAP4K14.37765048
3MAP3K103.15731652
4ITK2.93539223
5STK102.89958202
6ZAP702.41320208
7CDK122.35083482
8FES2.33739733
9JAK32.21690965
10KDR2.19359701
11RIPK42.14588403
12GRK62.14523564
13IKBKE2.13737102
14SMG12.03969520
15EEF2K1.97505460
16CDC71.90982188
17MST41.90713961
18CAMKK21.84172319
19MAP3K131.74368484
20FGFR31.72696619
21TEC1.59686249
22CAMKK11.56312982
23SRPK11.54559309
24FGFR41.52443696
25CLK11.49436126
26LCK1.48678456
27MAP3K141.48345949
28PASK1.46651094
29SIK31.39808905
30STK41.37462440
31TAOK31.34218354
32BRD41.33076796
33MAP2K31.30522116
34CSK1.27836315
35TYK21.27263933
36FGFR21.24179839
37BUB11.22155201
38TRIB31.20003524
39NUAK11.18048013
40MELK1.17674865
41MARK31.17520669
42NME21.17473448
43TGFBR11.15253162
44PIM11.14858813
45MKNK21.11044411
46BTK1.09455392
47RPS6KA41.06907623
48CDK41.05681634
49JAK11.05167701
50* NLK1.04898801
51NEK21.03923932
52CHUK1.02782044
53SYK1.02320593
54CDK91.01924447
55MAP3K31.00899026
56TESK20.98776545
57HCK0.97578541
58IRAK40.97378725
59TSSK60.97334455
60PLK40.96264443
61ATR0.94313690
62TLK10.94060617
63MAP3K10.92538990
64ICK0.92326277
65PRKD20.90469100
66PRKCQ0.89459595
67MAPK120.89240440
68MAPK70.87500346
69SIK20.83285578
70MARK20.80945018
71CAMK40.79786013
72VRK10.79438115
73CHEK10.78901797
74TNK20.77615307
75PRKCH0.74953678
76YES10.74807044
77CDK70.74261151
78JAK20.74232279
79CDK80.73994900
80RPS6KB20.72297844
81FGFR10.71336877
82MAP3K110.71186655
83ATM0.69863772
84PDGFRB0.68662637
85IKBKB0.68109299
86LRRK20.66005222
87MKNK10.65329971
88TAOK20.64894484
89KSR20.64093001
90CDK60.63554501
91SIK10.62527261
92MAP3K70.61471921
93IRAK20.59636833
94PDK10.58781869
95TBK10.58572934
96AURKB0.58027545
97WNK10.57539998
98CHEK20.56712780
99HIPK20.55581562
100ERN10.55247670
101EPHB10.54849424
102DMPK0.54147923
103TAF10.52943146
104TGFBR20.52792848
105ACVR1B0.52106688
106SCYL20.51751000
107LYN0.51500936
108PLK10.50606906
109NTRK20.50263560
110IRAK10.49002370
111RET0.48635328
112MAP3K80.48430482
113CDK20.47959032
114TYRO30.46476941
115INSR0.45866794
116TTK0.45036973
117TAOK10.44778876
118NEK60.42051649
119MAP3K20.41513948
120STK30.41236979
121SGK20.39316332
122FYN0.39279667
123SGK30.37001411
124MAPK110.36189484
125RAF10.36114038
126STK110.35050199
127MAPK30.34124585
128FGR0.33006300
129CDC42BPA0.32920878
130PKN20.32802532
131PLK30.32588593
132IGF1R0.32587545
133PRPF4B0.32438248
134* CDK10.32210657
135ALK0.31959885
136PIK3CG0.31033871
137BLK0.29762601
138PTK60.28175961

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.13866603
2T cell receptor signaling pathway_Homo sapiens_hsa046602.95769109
3Spliceosome_Homo sapiens_hsa030402.20471177
4Non-homologous end-joining_Homo sapiens_hsa034502.17373108
5DNA replication_Homo sapiens_hsa030302.16664674
6Measles_Homo sapiens_hsa051622.15517321
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.11667032
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.99764444
9Mismatch repair_Homo sapiens_hsa034301.99063611
10Intestinal immune network for IgA production_Homo sapiens_hsa046721.90627614
11Fanconi anemia pathway_Homo sapiens_hsa034601.78544032
12Cell cycle_Homo sapiens_hsa041101.77400037
13Ribosome_Homo sapiens_hsa030101.76542017
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.74014054
15Base excision repair_Homo sapiens_hsa034101.73309472
16Homologous recombination_Homo sapiens_hsa034401.67566441
17RNA degradation_Homo sapiens_hsa030181.65254907
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.64594459
19Hematopoietic cell lineage_Homo sapiens_hsa046401.64025928
20Graft-versus-host disease_Homo sapiens_hsa053321.62606162
21mRNA surveillance pathway_Homo sapiens_hsa030151.59104803
22RNA transport_Homo sapiens_hsa030131.55988887
23HTLV-I infection_Homo sapiens_hsa051661.55161758
24Antigen processing and presentation_Homo sapiens_hsa046121.54520246
25Herpes simplex infection_Homo sapiens_hsa051681.49590761
26Allograft rejection_Homo sapiens_hsa053301.37997882
27Notch signaling pathway_Homo sapiens_hsa043301.36338848
28Viral myocarditis_Homo sapiens_hsa054161.35723463
29Basal transcription factors_Homo sapiens_hsa030221.34161790
30Nucleotide excision repair_Homo sapiens_hsa034201.30860969
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.30192854
32* Basal cell carcinoma_Homo sapiens_hsa052171.19998337
33Glioma_Homo sapiens_hsa052141.17419345
34* Colorectal cancer_Homo sapiens_hsa052101.16578025
35B cell receptor signaling pathway_Homo sapiens_hsa046621.15215811
36Hepatitis B_Homo sapiens_hsa051611.14698803
37p53 signaling pathway_Homo sapiens_hsa041151.12652795
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.12364342
39Transcriptional misregulation in cancer_Homo sapiens_hsa052021.10748894
40Autoimmune thyroid disease_Homo sapiens_hsa053201.08837487
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.08378627
42Chronic myeloid leukemia_Homo sapiens_hsa052201.08265766
43VEGF signaling pathway_Homo sapiens_hsa043701.07112148
44Osteoclast differentiation_Homo sapiens_hsa043801.06285190
45Dorso-ventral axis formation_Homo sapiens_hsa043201.05067935
46* Adherens junction_Homo sapiens_hsa045201.04046283
47RNA polymerase_Homo sapiens_hsa030201.03469203
48Epstein-Barr virus infection_Homo sapiens_hsa051691.00138181
49MicroRNAs in cancer_Homo sapiens_hsa052060.97343750
50Neurotrophin signaling pathway_Homo sapiens_hsa047220.97297024
51Viral carcinogenesis_Homo sapiens_hsa052030.96787673
52mTOR signaling pathway_Homo sapiens_hsa041500.94731535
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94423404
54Pancreatic cancer_Homo sapiens_hsa052120.93965616
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92026116
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.90184168
57Alcoholism_Homo sapiens_hsa050340.89802165
58One carbon pool by folate_Homo sapiens_hsa006700.87468631
59* Acute myeloid leukemia_Homo sapiens_hsa052210.86747619
60Inositol phosphate metabolism_Homo sapiens_hsa005620.86277879
61Malaria_Homo sapiens_hsa051440.84929087
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84618658
63Leishmaniasis_Homo sapiens_hsa051400.83048724
64Tuberculosis_Homo sapiens_hsa051520.82779262
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82085033
66* Wnt signaling pathway_Homo sapiens_hsa043100.81446855
67Influenza A_Homo sapiens_hsa051640.81433351
68Shigellosis_Homo sapiens_hsa051310.80235282
69* Prostate cancer_Homo sapiens_hsa052150.80084995
70Small cell lung cancer_Homo sapiens_hsa052220.79954139
71Toxoplasmosis_Homo sapiens_hsa051450.78750138
72Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77975484
73Chemokine signaling pathway_Homo sapiens_hsa040620.75731530
74* Pathways in cancer_Homo sapiens_hsa052000.75090705
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.74458789
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74084197
77Hedgehog signaling pathway_Homo sapiens_hsa043400.74076796
78ErbB signaling pathway_Homo sapiens_hsa040120.73553813
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73504523
80Pyrimidine metabolism_Homo sapiens_hsa002400.72252936
81FoxO signaling pathway_Homo sapiens_hsa040680.72144421
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72063872
83Apoptosis_Homo sapiens_hsa042100.70946347
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69943360
85TGF-beta signaling pathway_Homo sapiens_hsa043500.67458272
86Long-term potentiation_Homo sapiens_hsa047200.66578366
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65451117
88TNF signaling pathway_Homo sapiens_hsa046680.63553620
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63216687
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61855386
91Non-small cell lung cancer_Homo sapiens_hsa052230.60974277
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.58811616
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.57448955
94Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56934446
95* Hippo signaling pathway_Homo sapiens_hsa043900.56350356
96Staphylococcus aureus infection_Homo sapiens_hsa051500.55894400
97Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53529518
98Rap1 signaling pathway_Homo sapiens_hsa040150.53126168
99Prolactin signaling pathway_Homo sapiens_hsa049170.51570292
100GnRH signaling pathway_Homo sapiens_hsa049120.51222544
101HIF-1 signaling pathway_Homo sapiens_hsa040660.51187549
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51152789
103Platelet activation_Homo sapiens_hsa046110.50873941
104Type I diabetes mellitus_Homo sapiens_hsa049400.50766825
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50193622
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50035067
107Ras signaling pathway_Homo sapiens_hsa040140.49595023
108Hepatitis C_Homo sapiens_hsa051600.49568198
109Proteasome_Homo sapiens_hsa030500.49173655
110Lysine degradation_Homo sapiens_hsa003100.48554626
111Choline metabolism in cancer_Homo sapiens_hsa052310.47226646
112Renal cell carcinoma_Homo sapiens_hsa052110.46232417
113* Endometrial cancer_Homo sapiens_hsa052130.45421011
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44690749
115* Thyroid cancer_Homo sapiens_hsa052160.43809820
116Systemic lupus erythematosus_Homo sapiens_hsa053220.43056907
117Proteoglycans in cancer_Homo sapiens_hsa052050.42991114
118MAPK signaling pathway_Homo sapiens_hsa040100.41890152
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40613185
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39461930
121Insulin resistance_Homo sapiens_hsa049310.38218981
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37556257
123Regulation of autophagy_Homo sapiens_hsa041400.35779936
124Legionellosis_Homo sapiens_hsa051340.35544880

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