LEFTY2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. This gene is closely linked to both a related family member and a related pseudogene. This gene encodes multiple isoforms that may undergo similar proteolytic processing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1receptor guanylyl cyclase signaling pathway (GO:0007168)8.92376415
2muscle organ morphogenesis (GO:0048644)8.85531675
3regulation of Wnt signaling pathway involved in heart development (GO:0003307)8.64475142
4negative regulation of activin receptor signaling pathway (GO:0032926)8.09255335
5positive regulation of urine volume (GO:0035810)8.06953681
6signal transduction involved in regulation of gene expression (GO:0023019)8.04605638
7regulation of mesoderm development (GO:2000380)7.49695379
8regulation of cardioblast differentiation (GO:0051890)6.61951479
9positive regulation of renal sodium excretion (GO:0035815)6.61119157
10negative regulation of cell fate specification (GO:0009996)6.36943508
11embryonic foregut morphogenesis (GO:0048617)6.23702678
12atrioventricular valve morphogenesis (GO:0003181)6.11643940
13digestive tract morphogenesis (GO:0048546)6.10204461
14neural crest cell development (GO:0014032)6.05148801
15cGMP biosynthetic process (GO:0006182)6.03473324
16transcytosis (GO:0045056)5.99256500
17endoderm formation (GO:0001706)5.85512944
18retinoic acid receptor signaling pathway (GO:0048384)5.75154889
19regulation of urine volume (GO:0035809)5.63964238
20regulation of posttranscriptional gene silencing (GO:0060147)5.63774866
21regulation of gene silencing by miRNA (GO:0060964)5.63774866
22regulation of gene silencing by RNA (GO:0060966)5.63774866
23retinoic acid metabolic process (GO:0042573)5.55943470
24hormone catabolic process (GO:0042447)5.24834765
25regulation of activin receptor signaling pathway (GO:0032925)5.20680468
26dorsal/ventral neural tube patterning (GO:0021904)5.15713081
27female gonad development (GO:0008585)5.09562798
28regulation of gastrulation (GO:0010470)5.04271330
29somatic hypermutation of immunoglobulin genes (GO:0016446)4.99269192
30somatic diversification of immune receptors via somatic mutation (GO:0002566)4.99269192
31response to BMP (GO:0071772)4.97297394
32cellular response to BMP stimulus (GO:0071773)4.97297394
33formation of translation preinitiation complex (GO:0001731)4.87531527
34phenol-containing compound catabolic process (GO:0019336)4.87386696
35SMAD protein signal transduction (GO:0060395)4.70272561
36regulation of glucocorticoid metabolic process (GO:0031943)4.62851923
37negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.61323945
38regulation of helicase activity (GO:0051095)4.59842853
39mesenchymal cell development (GO:0014031)4.58148738
40phagocytosis, recognition (GO:0006910)4.41219821
41DNA replication initiation (GO:0006270)4.37639053
42DNA unwinding involved in DNA replication (GO:0006268)4.32246511
43negative regulation of cell fate commitment (GO:0010454)4.29623956
44nuclear pore organization (GO:0006999)4.24725861
45sequestering of extracellular ligand from receptor (GO:0035581)4.20184122
46protein localization to kinetochore (GO:0034501)4.20086980
47proline biosynthetic process (GO:0006561)4.19778346
48anterior/posterior axis specification, embryo (GO:0008595)4.19682945
49organ formation (GO:0048645)4.18577173
50DNA replication-dependent nucleosome assembly (GO:0006335)4.14874625
51DNA replication-dependent nucleosome organization (GO:0034723)4.14874625
52folic acid-containing compound biosynthetic process (GO:0009396)4.13106965
53lung morphogenesis (GO:0060425)4.12948834
54histone H4-K12 acetylation (GO:0043983)4.11283813
55DNA strand elongation involved in DNA replication (GO:0006271)4.11253610
56regulation of renal sodium excretion (GO:0035813)3.99007756
57positive regulation of hair cycle (GO:0042635)3.98674815
58positive regulation of hair follicle development (GO:0051798)3.98674815
59regulation of excretion (GO:0044062)3.94307286
60mitotic sister chromatid segregation (GO:0000070)3.93353231
61nuclear pore complex assembly (GO:0051292)3.89043787
62regulation of nuclear cell cycle DNA replication (GO:0033262)3.88507402
63DNA strand elongation (GO:0022616)3.87267613
64histone arginine methylation (GO:0034969)3.86566579
65gastrulation (GO:0007369)3.86532569
66regulation of translational fidelity (GO:0006450)3.86228862
67telomere maintenance via semi-conservative replication (GO:0032201)3.84459045
68determination of adult lifespan (GO:0008340)3.84399505
69ribosome biogenesis (GO:0042254)3.83649808
70mitotic metaphase plate congression (GO:0007080)3.80777666
71ribosome assembly (GO:0042255)3.80736458
72heterochromatin organization (GO:0070828)3.80580621
73mitotic nuclear envelope disassembly (GO:0007077)3.79517678
74regulation of vascular permeability (GO:0043114)3.79357458
75transcription from mitochondrial promoter (GO:0006390)3.77999091
76cardiac muscle hypertrophy in response to stress (GO:0014898)3.75133761
77muscle hypertrophy in response to stress (GO:0003299)3.75133761
78cardiac muscle adaptation (GO:0014887)3.75133761
79stem cell development (GO:0048864)3.74716498
80cGMP metabolic process (GO:0046068)3.74429377
81regulation of cell fate specification (GO:0042659)3.72831724
82nucleobase biosynthetic process (GO:0046112)3.70343467
83embryonic heart tube development (GO:0035050)3.70254564
84replication fork processing (GO:0031297)3.69991299
85DNA replication checkpoint (GO:0000076)3.68841620
86maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.68267533
87branching involved in labyrinthine layer morphogenesis (GO:0060670)3.68101225
88pre-miRNA processing (GO:0031054)3.68008159
89regulation of retinoic acid receptor signaling pathway (GO:0048385)3.67045376
90dorsal/ventral axis specification (GO:0009950)3.64152193
91embryonic process involved in female pregnancy (GO:0060136)3.63709849
92nodal signaling pathway (GO:0038092)3.61920706
93mRNA transcription from RNA polymerase II promoter (GO:0042789)3.61747802
94DNA geometric change (GO:0032392)3.60195858
95positive regulation of osteoblast proliferation (GO:0033690)3.60051891
96facial nerve structural organization (GO:0021612)3.59784751
97DNA duplex unwinding (GO:0032508)3.59552595
98primitive streak formation (GO:0090009)3.54553995
99nuclear envelope disassembly (GO:0051081)3.52000957
100membrane disassembly (GO:0030397)3.52000957
101IMP biosynthetic process (GO:0006188)3.50265914
102establishment of apical/basal cell polarity (GO:0035089)3.48489519
103embryonic camera-type eye development (GO:0031076)3.45899604
104positive regulation of SMAD protein import into nucleus (GO:0060391)3.44321792
105positive regulation of p38MAPK cascade (GO:1900745)3.40250199
106regulation of development, heterochronic (GO:0040034)3.39724629
107regulation of telomere maintenance via telomerase (GO:0032210)3.37761327
108genitalia morphogenesis (GO:0035112)3.37528737
109purine nucleobase biosynthetic process (GO:0009113)3.37434185
110regulation of timing of cell differentiation (GO:0048505)3.36691337
111protein localization to chromosome, centromeric region (GO:0071459)3.35559560
112negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.35030717
113cardiocyte differentiation (GO:0035051)3.34894423
114maternal placenta development (GO:0001893)3.33920563
115sister chromatid segregation (GO:0000819)3.32916384
116regulation of transforming growth factor beta1 production (GO:0032908)3.31215983
117negative regulation of androgen receptor signaling pathway (GO:0060766)3.28498403
118endodermal cell differentiation (GO:0035987)3.28385781
119ribonucleoprotein complex biogenesis (GO:0022613)3.28032100
120maturation of SSU-rRNA (GO:0030490)3.27468644
121DNA deamination (GO:0045006)3.27348621
122metaphase plate congression (GO:0051310)3.26316204
123histone H4-K5 acetylation (GO:0043981)3.26314804
124histone H4-K8 acetylation (GO:0043982)3.26314804
125telomere maintenance via recombination (GO:0000722)3.25798362
126paraxial mesoderm development (GO:0048339)3.25741720
127telomere maintenance via telomere lengthening (GO:0010833)3.25025410
128cellular modified amino acid catabolic process (GO:0042219)3.24100574
129regulation of stem cell maintenance (GO:2000036)3.23311215
130nucleotide-excision repair, DNA gap filling (GO:0006297)3.21220050
131regulation of double-strand break repair via homologous recombination (GO:0010569)3.20497888
132renal system development (GO:0072001)3.20238492
133cell migration involved in gastrulation (GO:0042074)3.16339025
134fat-soluble vitamin metabolic process (GO:0006775)3.15362205
135positive regulation of cardiac muscle cell proliferation (GO:0060045)3.14708236
136regulation of gene silencing (GO:0060968)3.14347670
137mitochondrial DNA metabolic process (GO:0032042)3.14303971
138regulation of histone H3-K9 methylation (GO:0051570)3.13603260
139mitotic recombination (GO:0006312)3.11564918
140establishment of integrated proviral latency (GO:0075713)3.11039017
141regulation of transforming growth factor beta2 production (GO:0032909)3.09574914
142regulation of centrosome cycle (GO:0046605)3.09299710
143IMP metabolic process (GO:0046040)3.07536420
144DNA strand renaturation (GO:0000733)3.06248401
145Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.05808880
146glomerular visceral epithelial cell development (GO:0072015)3.03967239
147positive regulation of chromosome segregation (GO:0051984)3.03739387
148regulation of hair follicle development (GO:0051797)3.02378457
149regulation of tight junction assembly (GO:2000810)3.01900230
150mismatch repair (GO:0006298)3.01495330
151kinetochore assembly (GO:0051382)3.01232320
152mitotic G1 DNA damage checkpoint (GO:0031571)3.00959520
153L-ascorbic acid metabolic process (GO:0019852)2.99731850
154negative regulation of chromosome segregation (GO:0051985)2.99346281
155chromatin remodeling at centromere (GO:0031055)2.99316534
156cell fate specification (GO:0001708)2.99085358
157planar cell polarity pathway involved in neural tube closure (GO:0090179)2.98929234
158kinetochore organization (GO:0051383)2.98864073
159positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.98668325
160positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.98668325
161positive regulation of mitotic sister chromatid separation (GO:1901970)2.98668325
162negative regulation of gene silencing (GO:0060969)2.97740285
163proline metabolic process (GO:0006560)2.96920977
164establishment or maintenance of monopolar cell polarity (GO:0061339)2.96543922
165establishment of monopolar cell polarity (GO:0061162)2.96543922
166meiotic chromosome segregation (GO:0045132)2.96168814
167non-canonical Wnt signaling pathway (GO:0035567)2.96144383
168rRNA processing (GO:0006364)2.96116400
169convergent extension (GO:0060026)2.95659864
170epithelial cell-cell adhesion (GO:0090136)2.95262716
171peptidyl-arginine omega-N-methylation (GO:0035247)2.95183535
172establishment of protein localization to mitochondrial membrane (GO:0090151)2.95120762
173regulation of establishment of planar polarity (GO:0090175)2.94826879
174pseudouridine synthesis (GO:0001522)2.94474555
175chondrocyte proliferation (GO:0035988)2.93507208
176regulation of double-strand break repair (GO:2000779)2.92861628
177thyroid hormone generation (GO:0006590)2.92413315
178ectodermal placode formation (GO:0060788)2.92168546
179protein K6-linked ubiquitination (GO:0085020)2.92054802
180negative regulation of histone methylation (GO:0031061)2.91191245
181trophectodermal cell differentiation (GO:0001829)2.89190287
182attachment of spindle microtubules to kinetochore (GO:0008608)2.88940894
183pericardium development (GO:0060039)2.88361596
184outflow tract septum morphogenesis (GO:0003148)2.88010219
185negative regulation of hormone biosynthetic process (GO:0032353)2.86092134
186mitochondrial RNA metabolic process (GO:0000959)2.85862473
187rRNA metabolic process (GO:0016072)2.85828106
188pteridine-containing compound biosynthetic process (GO:0042559)2.85575697
189anterior/posterior axis specification (GO:0009948)2.85529459
190regulation of sister chromatid cohesion (GO:0007063)2.85127655
191cardiac right ventricle morphogenesis (GO:0003215)2.83562155
192regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.81378779
193vitamin catabolic process (GO:0009111)13.8507388
194fat-soluble vitamin catabolic process (GO:0042363)13.8507388

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.43965861
2* SMAD3_21741376_ChIP-Seq_HESCs_Human4.95885531
3* KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.13391850
4* KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.13391850
5* KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.13391850
6MYC_18555785_ChIP-Seq_MESCs_Mouse4.09100417
7SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.29370229
8* EOMES_21245162_ChIP-Seq_HESCs_Human3.29194814
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.26911218
10* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.26413099
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.23795294
12* SMAD4_21741376_ChIP-Seq_HESCs_Human3.12744280
13POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.05188852
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.96987556
15* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.81547497
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.72237344
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.69894226
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.67076670
19NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.66721862
20TCF3_18692474_ChIP-Seq_MEFs_Mouse2.53135896
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.50725940
22NANOG_18555785_ChIP-Seq_MESCs_Mouse2.48916156
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.42669459
24CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.33848540
25* SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.32119183
26* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.29903042
27* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.24376836
28* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.23902566
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.20976345
30ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.20499696
31PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.19459377
32* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.12580641
33* STAT3_1855785_ChIP-Seq_MESCs_Mouse2.11050788
34* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.06627980
35NELFA_20434984_ChIP-Seq_ESCs_Mouse2.01147355
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.00806841
37EED_16625203_ChIP-ChIP_MESCs_Mouse2.00364461
38* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.97884250
39EST1_17652178_ChIP-ChIP_JURKAT_Human1.93874783
40* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.89587921
41KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.87743248
42ETS1_20019798_ChIP-Seq_JURKAT_Human1.86889429
43* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.86617674
44SALL4_18804426_ChIP-ChIP_XEN_Mouse1.84210637
45* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.83947791
46JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.83122199
47WT1_19549856_ChIP-ChIP_CCG9911_Human1.79918947
48XRN2_22483619_ChIP-Seq_HELA_Human1.77995100
49* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.77417681
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.76803593
51KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.75788791
52SRY_22984422_ChIP-ChIP_TESTIS_Rat1.75664824
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74805587
54* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.73598035
55HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.73022104
56POU5F1_16518401_ChIP-PET_MESCs_Mouse1.72249803
57ZNF263_19887448_ChIP-Seq_K562_Human1.64793457
58TP53_20018659_ChIP-ChIP_R1E_Mouse1.64112010
59MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.63358165
60CREB1_15753290_ChIP-ChIP_HEK293T_Human1.61601006
61SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.59982923
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.59261783
63SALL1_21062744_ChIP-ChIP_HESCs_Human1.59214300
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.58217441
65* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.58119317
66EZH2_27304074_Chip-Seq_ESCs_Mouse1.57911430
67SOX2_18692474_ChIP-Seq_MEFs_Mouse1.57560487
68GABP_17652178_ChIP-ChIP_JURKAT_Human1.57370099
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52653649
70* SOX2_16153702_ChIP-ChIP_HESCs_Human1.48031786
71YY1_21170310_ChIP-Seq_MESCs_Mouse1.46747177
72NANOG_18692474_ChIP-Seq_MEFs_Mouse1.46010934
73E2F1_21310950_ChIP-Seq_MCF-7_Human1.45608661
74NANOG_21062744_ChIP-ChIP_HESCs_Human1.45484069
75OCT4_18692474_ChIP-Seq_MEFs_Mouse1.45440182
76EGR1_19374776_ChIP-ChIP_THP-1_Human1.45243438
77AR_21909140_ChIP-Seq_LNCAP_Human1.44581912
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.44294614
79THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43225395
80* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.43129205
81TTF2_22483619_ChIP-Seq_HELA_Human1.38657893
82NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.37597951
83* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.36578796
84* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35857671
85KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34231525
86* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.33915120
87E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.32518349
88VDR_23849224_ChIP-Seq_CD4+_Human1.32231018
89DCP1A_22483619_ChIP-Seq_HELA_Human1.28842495
90GABP_19822575_ChIP-Seq_HepG2_Human1.22425691
91* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19548912
92* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.19319299
93TP63_19390658_ChIP-ChIP_HaCaT_Human1.18212445
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17985582
95MYC_22102868_ChIP-Seq_BL_Human1.17361380
96FOXP3_21729870_ChIP-Seq_TREG_Human1.16703899
97ESR1_21235772_ChIP-Seq_MCF-7_Human1.16027123
98SOX17_20123909_ChIP-Seq_XEN_Mouse1.15507747
99RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14282796
100ERG_21242973_ChIP-ChIP_JURKAT_Human1.12113104
101EZH2_18974828_ChIP-Seq_MESCs_Mouse1.11943435
102RNF2_18974828_ChIP-Seq_MESCs_Mouse1.11943435
103YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11775122
104MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09956620
105KDM5A_27292631_Chip-Seq_BREAST_Human1.09668130
106ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09310451
107CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08470377
108* KAP1_27257070_Chip-Seq_ESCs_Mouse1.07122649
109DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06606290
110SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.06399285
111* NANOG_16518401_ChIP-PET_MESCs_Mouse1.06117322
112SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.05338672
113TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.02940209
114* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.02395618
115TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.01732581
116CLOCK_20551151_ChIP-Seq_293T_Human1.00907293
117* TFEB_21752829_ChIP-Seq_HELA_Human1.00422811
118PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00040270
119TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.99060547
120PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.98068316
121IRF1_19129219_ChIP-ChIP_H3396_Human0.96702633
122HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.95336000
123* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95300195
124ISL1_27105846_Chip-Seq_CPCs_Mouse0.95144826
125RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93438368
126* RING1B_27294783_Chip-Seq_ESCs_Mouse0.92639027
127SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.92457513
128HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.91852418
129* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91221720
130EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.91205464
131RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88496732
132RNF2_27304074_Chip-Seq_ESCs_Mouse0.86367924
133SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85818538
134ZFP281_27345836_Chip-Seq_ESCs_Mouse0.84493590
135ELK1_19687146_ChIP-ChIP_HELA_Human0.84408162
136* NANOG_16153702_ChIP-ChIP_HESCs_Human0.83789290
137TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80237200
138SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.76661496
139BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.73287266
140* CTCF_27219007_Chip-Seq_Bcells_Human0.71135470
141SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.69882580
142RING1B_27294783_Chip-Seq_NPCs_Mouse0.68706003
143SA1_22415368_ChIP-Seq_MEFs_Mouse0.67820308
144WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.67073039

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.21553509
2MP0004957_abnormal_blastocyst_morpholog4.34525565
3MP0008004_abnormal_stomach_pH4.13224690
4MP0010094_abnormal_chromosome_stability4.03282045
5MP0002163_abnormal_gland_morphology3.92787802
6MP0000462_abnormal_digestive_system3.87246416
7MP0003693_abnormal_embryo_hatching3.75005762
8MP0003111_abnormal_nucleus_morphology3.55185868
9MP0003890_abnormal_embryonic-extraembry3.34235351
10* MP0004133_heterotaxia3.33020465
11MP0003077_abnormal_cell_cycle3.32382596
12MP0010352_gastrointestinal_tract_polyps2.96817742
13MP0002653_abnormal_ependyma_morphology2.96488147
14MP0008058_abnormal_DNA_repair2.94898968
15MP0003122_maternal_imprinting2.88435691
16MP0003806_abnormal_nucleotide_metabolis2.81150728
17MP0003385_abnormal_body_wall2.76997835
18MP0005379_endocrine/exocrine_gland_phen2.56336886
19MP0008932_abnormal_embryonic_tissue2.45984051
20MP0001348_abnormal_lacrimal_gland2.44361392
21MP0001730_embryonic_growth_arrest2.34933450
22MP0002233_abnormal_nose_morphology2.34108266
23MP0010030_abnormal_orbit_morphology2.29863512
24MP0003119_abnormal_digestive_system2.24139696
25MP0000350_abnormal_cell_proliferation2.23751584
26MP0005084_abnormal_gallbladder_morpholo2.20772138
27MP0003123_paternal_imprinting2.14813279
28* MP0002084_abnormal_developmental_patter2.12832373
29MP0003136_yellow_coat_color2.11774817
30MP0000372_irregular_coat_pigmentation2.07424863
31MP0006292_abnormal_olfactory_placode2.06599367
32* MP0005380_embryogenesis_phenotype2.05526090
33* MP0001672_abnormal_embryogenesis/_devel2.05526090
34MP0001293_anophthalmia2.05445145
35* MP0002085_abnormal_embryonic_tissue2.02273568
36MP0008789_abnormal_olfactory_epithelium1.93272862
37MP0001697_abnormal_embryo_size1.92862101
38MP0009384_cardiac_valve_regurgitation1.85173813
39* MP0002086_abnormal_extraembryonic_tissu1.82993530
40MP0004197_abnormal_fetal_growth/weight/1.80943450
41MP0002132_abnormal_respiratory_system1.79622895
42MP0003984_embryonic_growth_retardation1.75636375
43MP0002088_abnormal_embryonic_growth/wei1.72502078
44MP0008007_abnormal_cellular_replicative1.71035441
45MP0003786_premature_aging1.69754101
46MP0002736_abnormal_nociception_after1.58423390
47MP0003941_abnormal_skin_development1.57024318
48* MP0002080_prenatal_lethality1.56128500
49MP0010307_abnormal_tumor_latency1.55321776
50MP0004272_abnormal_basement_membrane1.55045600
51MP0003718_maternal_effect1.48236281
52MP0004264_abnormal_extraembryonic_tissu1.45505642
53MP0003279_aneurysm1.45311519
54MP0003705_abnormal_hypodermis_morpholog1.40766579
55MP0008877_abnormal_DNA_methylation1.37904733
56MP0005266_abnormal_metabolism1.30336431
57MP0003632_abnormal_nervous_system1.30129823
58MP0006054_spinal_hemorrhage1.27862661
59MP0005076_abnormal_cell_differentiation1.25365617
60MP0002111_abnormal_tail_morphology1.23856962
61MP0005187_abnormal_penis_morphology1.19813426
62MP0005367_renal/urinary_system_phenotyp1.19448284
63MP0000516_abnormal_urinary_system1.19448284
64MP0003121_genomic_imprinting1.19354428
65MP0000313_abnormal_cell_death1.17519813
66MP0002249_abnormal_larynx_morphology1.15511586
67MP0000490_abnormal_crypts_of1.14730708
68MP0005381_digestive/alimentary_phenotyp1.13227641
69MP0001145_abnormal_male_reproductive1.12479170
70MP0006072_abnormal_retinal_apoptosis1.10992486
71MP0004233_abnormal_muscle_weight1.09990756
72MP0002210_abnormal_sex_determination1.09970067
73MP0003566_abnormal_cell_adhesion1.09320368
74MP0002090_abnormal_vision1.07753498
75MP0003567_abnormal_fetal_cardiomyocyte1.06942630
76MP0004381_abnormal_hair_follicle1.05251310
77MP0002019_abnormal_tumor_incidence1.03577025
78MP0009278_abnormal_bone_marrow1.03308134
79MP0002332_abnormal_exercise_endurance0.97510469
80MP0001286_abnormal_eye_development0.97344305
81MP0002928_abnormal_bile_duct0.96447366
82MP0000432_abnormal_head_morphology0.93825009
83MP0001849_ear_inflammation0.89612639
84MP0002092_abnormal_eye_morphology0.89309007
85MP0003936_abnormal_reproductive_system0.88278474
86MP0001984_abnormal_olfaction0.85988119
87MP0002127_abnormal_cardiovascular_syste0.85928814
88* MP0003861_abnormal_nervous_system0.84700189
89MP0002697_abnormal_eye_size0.84649805
90MP0004858_abnormal_nervous_system0.84437150
91MP0002254_reproductive_system_inflammat0.83738607
92MP0010630_abnormal_cardiac_muscle0.83530050
93MP0002277_abnormal_respiratory_mucosa0.83361162
94MP0000762_abnormal_tongue_morphology0.81727078
95MP0003935_abnormal_craniofacial_develop0.80668921
96MP0000653_abnormal_sex_gland0.80447102
97MP0005646_abnormal_pituitary_gland0.80427010
98MP0003938_abnormal_ear_development0.80310713
99MP0003937_abnormal_limbs/digits/tail_de0.80179418
100MP0002269_muscular_atrophy0.79510703
101MP0009053_abnormal_anal_canal0.79405127
102MP0000371_diluted_coat_color0.78980265
103MP0003755_abnormal_palate_morphology0.78672991
104MP0001929_abnormal_gametogenesis0.78561343
105MP0005023_abnormal_wound_healing0.76033174
106MP0005075_abnormal_melanosome_morpholog0.75537382
107MP0002114_abnormal_axial_skeleton0.75459993
108MP0000678_abnormal_parathyroid_gland0.75159618
109MP0003943_abnormal_hepatobiliary_system0.74813573
110MP0003315_abnormal_perineum_morphology0.73846688
111MP0003221_abnormal_cardiomyocyte_apopto0.73820944
112MP0009703_decreased_birth_body0.73300385
113MP0000470_abnormal_stomach_morphology0.73254621
114MP0005501_abnormal_skin_physiology0.71389474
115MP0003453_abnormal_keratinocyte_physiol0.71347560
116MP0002932_abnormal_joint_morphology0.70731653
117MP0000358_abnormal_cell_content/0.70555225
118MP0005499_abnormal_olfactory_system0.70265352
119MP0005394_taste/olfaction_phenotype0.70265352
120MP0008438_abnormal_cutaneous_collagen0.69576266
121MP0001727_abnormal_embryo_implantation0.69456306
122MP0005391_vision/eye_phenotype0.68428687
123MP0000049_abnormal_middle_ear0.68077398
124MP0002075_abnormal_coat/hair_pigmentati0.67892987
125MP0008770_decreased_survivor_rate0.67492485
126* MP0002925_abnormal_cardiovascular_devel0.66936995
127MP0000647_abnormal_sebaceous_gland0.66069026
128* MP0000266_abnormal_heart_morphology0.65922579
129MP0005384_cellular_phenotype0.63593760
130MP0000428_abnormal_craniofacial_morphol0.63454789
131MP0003186_abnormal_redox_activity0.63258393
132MP0006035_abnormal_mitochondrial_morpho0.63250226
133MP0002160_abnormal_reproductive_system0.62757310
134MP0002796_impaired_skin_barrier0.62436626
135MP0003137_abnormal_impulse_conducting0.61893626
136MP0001968_abnormal_touch/_nociception0.58472969
137MP0002109_abnormal_limb_morphology0.55376767
138MP0009672_abnormal_birth_weight0.53731135
139MP0002089_abnormal_postnatal_growth/wei0.53036496
140MP0002081_perinatal_lethality0.51005863
141MP0000566_synostosis0.50182485
142* MP0001614_abnormal_blood_vessel0.49818158
143MP0000163_abnormal_cartilage_morphology0.49586915
144MP0004147_increased_porphyrin_level0.46752232
145MP0002116_abnormal_craniofacial_bone0.46653576
146MP0005508_abnormal_skeleton_morphology0.46412023
147MP0001299_abnormal_eye_distance/0.46298081
148MP0000767_abnormal_smooth_muscle0.44593926
149MP0004087_abnormal_muscle_fiber0.43933096
150MP0005197_abnormal_uvea_morphology0.43532930
151MP0002152_abnormal_brain_morphology0.41476200
152MP0002102_abnormal_ear_morphology0.40503186
153MP0000026_abnormal_inner_ear0.38164254
154MP0001175_abnormal_lung_morphology0.38013289

Predicted human phenotypes

RankGene SetZ-score
1Congenital malformation of the right heart (HP:0011723)5.28116978
2Double outlet right ventricle (HP:0001719)5.28116978
3Ependymoma (HP:0002888)5.26380217
4Aplasia/Hypoplasia of the sacrum (HP:0008517)5.05126684
5Periauricular skin pits (HP:0100277)4.83089301
6Preauricular pit (HP:0004467)4.83089301
7Oligodactyly (hands) (HP:0001180)4.79393059
8Rib fusion (HP:0000902)4.67957259
9Abnormality of the pubic bones (HP:0003172)4.45621776
10Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)4.34325854
11Transposition of the great arteries (HP:0001669)4.28623530
12Abnormal connection of the cardiac segments (HP:0011545)4.28623530
13Abnormal ventriculo-arterial connection (HP:0011563)4.28623530
14Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)4.24792775
15Supernumerary spleens (HP:0009799)4.18394771
16Short middle phalanx of the 5th finger (HP:0004220)4.17358448
17Abnormality of the labia minora (HP:0012880)4.10663434
18Stenosis of the external auditory canal (HP:0000402)4.09844787
19Mixed hearing impairment (HP:0000410)4.08656185
20Absent radius (HP:0003974)4.04964190
21Astrocytoma (HP:0009592)3.94057886
22Abnormality of the astrocytes (HP:0100707)3.94057886
23Labial hypoplasia (HP:0000066)3.89452370
24Aplasia/hypoplasia of the humerus (HP:0006507)3.83672355
25Aplasia involving forearm bones (HP:0009822)3.80522969
26Absent forearm bone (HP:0003953)3.80522969
27Breast hypoplasia (HP:0003187)3.79277341
28Rectovaginal fistula (HP:0000143)3.79109684
29Rectal fistula (HP:0100590)3.79109684
30Abnormality of the fetal cardiovascular system (HP:0010948)3.76636529
31Abnormal umbilical cord blood vessels (HP:0011403)3.76636529
32Single umbilical artery (HP:0001195)3.76636529
33Hypoplastic female external genitalia (HP:0012815)3.74577470
34Medulloblastoma (HP:0002885)3.72917144
35Abnormality of the phalanges of the 5th finger (HP:0004213)3.65979610
36Short humerus (HP:0005792)3.64775315
37Aplasia/Hypoplasia of the breasts (HP:0010311)3.61596750
38Neoplasm of the oral cavity (HP:0100649)3.58985888
39Selective tooth agenesis (HP:0001592)3.57142659
40Birth length less than 3rd percentile (HP:0003561)3.57096255
41Rhabdomyosarcoma (HP:0002859)3.52872243
42Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.52655755
43Chromosomal breakage induced by crosslinking agents (HP:0003221)3.51715372
44Colon cancer (HP:0003003)3.47922428
45Erectile abnormalities (HP:0100639)3.44293167
46Agnosia (HP:0010524)3.38530469
47Chromsome breakage (HP:0040012)3.38457442
48Oligodactyly (HP:0012165)3.36340750
49Myelomeningocele (HP:0002475)3.32767419
50Intestinal fistula (HP:0100819)3.27038900
51Abdominal situs inversus (HP:0003363)3.25507485
52Abnormality of abdominal situs (HP:0011620)3.25507485
53Skin pits (HP:0100276)3.22495078
54Vaginal fistula (HP:0004320)3.22115340
55Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)3.22055708
56Shawl scrotum (HP:0000049)3.18698758
57Preaxial foot polydactyly (HP:0001841)3.14689498
58Glioma (HP:0009733)3.14036467
59Ankyloglossia (HP:0010296)3.13483061
60Ureteral duplication (HP:0000073)3.07699773
61Neoplasm of striated muscle (HP:0009728)3.01473167
62Abnormal pancreas size (HP:0012094)3.01164488
63Hypoplastic scapulae (HP:0000882)2.98219998
64Aplasia/Hypoplasia of the scapulae (HP:0006713)2.98219998
65Absent thumb (HP:0009777)2.97708105
66Hypochromic microcytic anemia (HP:0004840)2.95644598
67Absent eyebrow (HP:0002223)2.94069631
68Abnormality of the salivary glands (HP:0010286)2.93897751
69Chin dimple (HP:0010751)2.93307772
70Diastasis recti (HP:0001540)2.91752643
71Bifid tongue (HP:0010297)2.88986390
72Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.88724808
73Dislocated radial head (HP:0003083)2.88596324
74Mesomelia (HP:0003027)2.86994085
75Patellar aplasia (HP:0006443)2.84118243
76Abnormality of the ileum (HP:0001549)2.82488536
77Concave nail (HP:0001598)2.79867930
78Abnormal number of incisors (HP:0011064)2.78062766
79Thoracolumbar scoliosis (HP:0002944)2.74770618
80Abnormality of the radial head (HP:0003995)2.72152521
81Abnormality of the phalanges of the 2nd finger (HP:0009541)2.70412874
82Hepatoblastoma (HP:0002884)2.69469829
83Renal duplication (HP:0000075)2.69044653
84Brittle hair (HP:0002299)2.68585691
85Hydroureter (HP:0000072)2.68330741
86Abnormality of the labia (HP:0000058)2.66028669
87Abnormality of oral frenula (HP:0000190)2.62587122
88Meckel diverticulum (HP:0002245)2.60585274
89Missing ribs (HP:0000921)2.58627882
90Premature skin wrinkling (HP:0100678)2.57624646
91Asplenia (HP:0001746)2.56694984
92Aplasia/Hypoplasia of the patella (HP:0006498)2.54936461
93Hypoplastic nipples (HP:0002557)2.53867344
94Impulsivity (HP:0100710)2.53264881
95Carpal bone hypoplasia (HP:0001498)2.53004755
96Aplasia/Hypoplasia of the uvula (HP:0010293)2.52318348
97Basal cell carcinoma (HP:0002671)2.51477837
98Duplicated collecting system (HP:0000081)2.51424969
99Split foot (HP:0001839)2.50371616
100Intestinal atresia (HP:0011100)2.49630049
101Esophageal atresia (HP:0002032)2.48161969
102Facial hemangioma (HP:0000329)2.47423915
103Abnormality of the lower motor neuron (HP:0002366)2.47165225
104Long palpebral fissure (HP:0000637)2.45988281
105Oral leukoplakia (HP:0002745)2.45615081
106Abnormality of the umbilical cord (HP:0010881)2.44013410
107Reticulocytopenia (HP:0001896)2.42910331
108Horseshoe kidney (HP:0000085)2.40440232
109Ectopic anus (HP:0004397)2.39657909
110Tongue fasciculations (HP:0001308)2.39448345
111Vertebral fusion (HP:0002948)2.38616200
112Choroideremia (HP:0001139)2.35880463
113Small epiphyses (HP:0010585)2.35708983
114Aplasia/Hypoplasia of the spleen (HP:0010451)2.34858995
115Premature rupture of membranes (HP:0001788)2.33604059
116Abnormality of the preputium (HP:0100587)2.31857913
117Cerebral hypomyelination (HP:0006808)2.31580520
118Short 5th finger (HP:0009237)2.31235592
119Premature ovarian failure (HP:0008209)2.31202238
120Oligodontia (HP:0000677)2.31146032
121Gastrointestinal atresia (HP:0002589)2.30393472
122Anteriorly placed anus (HP:0001545)2.29563845
123Multiple enchondromatosis (HP:0005701)2.29023732
124Sex reversal (HP:0012245)2.28577927
125Abnormal sex determination (HP:0012244)2.28577927
126Absent toe (HP:0010760)2.28439800
127Abnormality of the humerus (HP:0003063)2.27648365
128Trismus (HP:0000211)2.27526272
129Fused cervical vertebrae (HP:0002949)2.26920537
130Abnormality of the distal phalanges of the toes (HP:0010182)2.24769883
131Abnormality of chromosome stability (HP:0003220)2.24072306
132Abnormality of the middle phalanges of the toes (HP:0010183)2.23888415
133Patent foramen ovale (HP:0001655)2.23704225
134Rocker bottom foot (HP:0001838)2.23686343
135Spinal muscular atrophy (HP:0007269)2.23602191
136Vitreoretinal degeneration (HP:0000655)2.23156137
137Nephroblastoma (Wilms tumor) (HP:0002667)2.21722726
138Hemivertebrae (HP:0002937)2.21062536
139Irregular epiphyses (HP:0010582)2.20589577
140Abnormality of the upper arm (HP:0001454)2.20407066
141Gynecomastia (HP:0000771)2.20395005
142Abnormality of the anterior horn cell (HP:0006802)2.20111967
143Degeneration of anterior horn cells (HP:0002398)2.20111967
144Supernumerary bones of the axial skeleton (HP:0009144)2.16253346
145Muscle fibrillation (HP:0010546)2.12606802
146Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.12331161
147Vertebral hypoplasia (HP:0008417)2.12331161
148Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.08535054
149Tracheoesophageal fistula (HP:0002575)2.08402339
150Abnormality of cochlea (HP:0000375)2.07815375
151Abnormality of the right ventricle (HP:0001707)2.07556196
152Supernumerary ribs (HP:0005815)2.06744288
153Abnormality of the renal collecting system (HP:0004742)2.06322879
154Broad thumb (HP:0011304)2.06096331
155Dysphonia (HP:0001618)2.05623791
156Thickened helices (HP:0000391)2.05488580
157Bilateral microphthalmos (HP:0007633)2.05458358
158Breast aplasia (HP:0100783)2.04892838
159Embryonal renal neoplasm (HP:0011794)2.03118775
160Short hallux (HP:0010109)2.02984403
161Vertebral clefting (HP:0008428)2.01231518
162Premature graying of hair (HP:0002216)2.00210932
163Abnormality of the humeroradial joint (HP:0100744)1.99641130
164Abnormality of the aortic arch (HP:0012303)1.98372628
165Biliary tract neoplasm (HP:0100574)1.97515980
166Gonadal dysgenesis (HP:0000133)1.96415248
167Anophthalmia (HP:0000528)1.95575803
168Orthostatic hypotension (HP:0001278)1.95336919
169Soft skin (HP:0000977)1.94126597
170Small intestinal stenosis (HP:0012848)1.93659155
171Duodenal stenosis (HP:0100867)1.93659155
172Conical tooth (HP:0000698)1.93199880
173Septo-optic dysplasia (HP:0100842)1.93089921
174Respiratory difficulties (HP:0002880)1.90825128
175Rough bone trabeculation (HP:0100670)1.90105588
176Myelodysplasia (HP:0002863)1.89966746
177Squamous cell carcinoma (HP:0002860)1.89193591
178Delayed puberty (HP:0000823)1.88380560
179Hypoplasia of the radius (HP:0002984)1.86408542
180Aplasia/Hypoplasia of the sternum (HP:0006714)1.86297934
181Abnormality of the duodenum (HP:0002246)1.85387734
182Abnormality of pyrimidine metabolism (HP:0004353)1.85107102
183Anal stenosis (HP:0002025)1.83456791
184Abnormal lung lobation (HP:0002101)1.82086280
185Broad alveolar ridges (HP:0000187)1.81973403
186Neoplasm of the pancreas (HP:0002894)1.81190014

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.41607543
2ERBB43.87887887
3WEE13.60803131
4ARAF3.58949617
5EPHA43.50150669
6BUB13.44483457
7EPHA23.32754396
8TTK3.08446092
9CDC73.03709727
10NEK12.84997087
11STK162.63657472
12AKT32.56200552
13ICK2.48144231
14CDK72.44690386
15LATS22.41272471
16TIE12.30575004
17PLK12.21183361
18NEK22.20801365
19RPS6KB22.08658780
20MAP2K71.95235921
21CHEK21.87236352
22DDR21.74365721
23NME11.69960674
24MAP3K131.68707104
25TYRO31.67743353
26ATR1.54632030
27DYRK31.53698892
28MATK1.52544091
29DAPK31.52217888
30MYLK1.50409216
31TESK21.48004779
32SRPK11.46800023
33KDR1.46344313
34PLK21.45613863
35MAP3K41.43052630
36PASK1.41487562
37NTRK11.41201008
38BRSK11.39369796
39ALK1.39050885
40PAK41.35337199
41AURKA1.34004894
42TSSK61.33265333
43CHEK11.30214549
44MAPKAPK31.27405988
45AURKB1.26296163
46STK101.25122203
47EIF2AK11.22929101
48FGFR21.21785940
49BCR1.20653121
50TRIM281.19202807
51PNCK1.17610843
52CDK61.14742850
53DAPK11.12736165
54BRD41.12497772
55PLK31.12370455
56MAP3K61.11852297
57MAP3K81.10924703
58NTRK31.08280282
59CDK41.07699706
60TTN1.06816360
61VRK21.06742464
62CDK21.05317921
63BMX1.04405551
64YES11.01658472
65MAP3K110.99432818
66ATM0.98807004
67DYRK20.95398284
68DAPK20.93447893
69ACVR1B0.89752854
70EIF2AK30.89084275
71MAPK150.88869113
72MOS0.88090284
73FGFR10.87701266
74PIM10.87604790
75PLK40.87135226
76FGR0.87091815
77MTOR0.85959548
78DMPK0.85124542
79MKNK10.84215089
80GRK60.83859805
81FLT30.82713035
82UHMK10.80336435
83PDK20.79752588
84MET0.78900255
85BRSK20.77181921
86PRKCI0.77128982
87STK40.76583563
88CSNK2A20.76500396
89MKNK20.75462258
90VRK10.74399394
91SCYL20.73805438
92MAP3K100.72347664
93TLK10.70908149
94CSNK1E0.70602700
95LIMK10.69687929
96CSK0.69258635
97CDK10.68872514
98STK38L0.67023534
99PRKG20.67012168
100CSNK2A10.66448889
101PAK10.65194244
102CDK190.64830003
103PDK30.64225366
104PDK40.64225366
105CSNK1G10.62883441
106WNK30.62725592
107MST40.61383991
108ROCK10.57411633
109AKT20.57151375
110CSNK1G30.56885526
111CSNK1G20.56771623
112ILK0.56206016
113MELK0.56029780
114PDGFRA0.55937195
115DYRK1B0.54724903
116TAOK20.53517052
117STK110.52306670
118CDK180.50600511
119TGFBR10.50549187
120TESK10.50164204
121BCKDK0.49625667
122MAP4K20.48748033
123CDK11A0.46341778
124PINK10.46082855
125CDK150.45923163
126PTK20.45503408
127GRK50.42916081
128PKN20.41560004
129CSNK1D0.41448576
130PRKDC0.40928431
131CSNK1A1L0.40867654
132PBK0.40026785
133MAPK10.39673046
134MAPK140.39482067
135CDC42BPA0.39403395
136CDK140.39210499
137GSK3A0.38127763
138KSR10.37542076
139RAF10.37288248
140NME20.37163657
141PRKD20.36483152
142EGFR0.36312406
143MAP3K90.36311425
144MAPK100.35612768
145RPS6KA40.35492507
146PRKCD0.35427164
147GSK3B0.35078912
148ROCK20.34828288
149MAPK90.34653171
150BRAF0.33765403
151LRRK20.33590964
152RPS6KC10.33091371
153GRK10.32198612
154BMPR1B0.31181766
155CLK10.31146096

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034305.29056796
2DNA replication_Homo sapiens_hsa030304.80630068
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.31870451
4One carbon pool by folate_Homo sapiens_hsa006703.38744858
5RNA transport_Homo sapiens_hsa030133.37961702
6Spliceosome_Homo sapiens_hsa030403.24408586
7Base excision repair_Homo sapiens_hsa034103.12633659
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.05983345
9Ribosome_Homo sapiens_hsa030102.83986664
10Homologous recombination_Homo sapiens_hsa034402.77896942
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.76936251
12Nucleotide excision repair_Homo sapiens_hsa034202.72904971
13Fanconi anemia pathway_Homo sapiens_hsa034602.53156765
14RNA polymerase_Homo sapiens_hsa030202.52123766
15Retinol metabolism_Homo sapiens_hsa008302.40517349
16Cell cycle_Homo sapiens_hsa041102.39987403
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.36419058
18mRNA surveillance pathway_Homo sapiens_hsa030152.13260554
19Proteasome_Homo sapiens_hsa030502.05985208
20Pyrimidine metabolism_Homo sapiens_hsa002401.72208497
21RNA degradation_Homo sapiens_hsa030181.71905256
22Non-homologous end-joining_Homo sapiens_hsa034501.69805463
23Biosynthesis of amino acids_Homo sapiens_hsa012301.64466668
24ECM-receptor interaction_Homo sapiens_hsa045121.60004049
25Fatty acid elongation_Homo sapiens_hsa000621.58018263
26p53 signaling pathway_Homo sapiens_hsa041151.55363352
27Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.53741761
28Basal transcription factors_Homo sapiens_hsa030221.50608285
29Protein digestion and absorption_Homo sapiens_hsa049741.41316412
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.41126276
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.38389021
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.35014872
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.34116360
34Melanogenesis_Homo sapiens_hsa049161.28772737
35N-Glycan biosynthesis_Homo sapiens_hsa005101.28750263
36Rap1 signaling pathway_Homo sapiens_hsa040151.28067389
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.23072349
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.19847238
39Hippo signaling pathway_Homo sapiens_hsa043901.17848299
40Basal cell carcinoma_Homo sapiens_hsa052171.15088616
41Folate biosynthesis_Homo sapiens_hsa007901.12892325
42* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.12116812
43Oocyte meiosis_Homo sapiens_hsa041141.09067393
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08057596
45Fructose and mannose metabolism_Homo sapiens_hsa000511.07234272
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.04215727
47Hedgehog signaling pathway_Homo sapiens_hsa043401.04026084
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.95462851
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95087714
50Selenocompound metabolism_Homo sapiens_hsa004500.93236465
51Fatty acid metabolism_Homo sapiens_hsa012120.89186862
52Focal adhesion_Homo sapiens_hsa045100.86822271
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85442753
54Vitamin B6 metabolism_Homo sapiens_hsa007500.84402894
55mTOR signaling pathway_Homo sapiens_hsa041500.84264130
56cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84138172
57Axon guidance_Homo sapiens_hsa043600.82963056
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82355145
59Arginine and proline metabolism_Homo sapiens_hsa003300.82066289
60* TGF-beta signaling pathway_Homo sapiens_hsa043500.81598082
61Epstein-Barr virus infection_Homo sapiens_hsa051690.79348629
62Fatty acid biosynthesis_Homo sapiens_hsa000610.78589680
63Ras signaling pathway_Homo sapiens_hsa040140.78490750
64Notch signaling pathway_Homo sapiens_hsa043300.78125509
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77985515
66Protein export_Homo sapiens_hsa030600.77335075
67Purine metabolism_Homo sapiens_hsa002300.71912178
68Carbon metabolism_Homo sapiens_hsa012000.71868230
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71452866
70Viral carcinogenesis_Homo sapiens_hsa052030.67711135
71Thyroid cancer_Homo sapiens_hsa052160.67055086
72Adherens junction_Homo sapiens_hsa045200.67004813
73MicroRNAs in cancer_Homo sapiens_hsa052060.66988652
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66235635
75Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65103967
76Bladder cancer_Homo sapiens_hsa052190.60171474
77Glutathione metabolism_Homo sapiens_hsa004800.57805908
78Systemic lupus erythematosus_Homo sapiens_hsa053220.55776285
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55594009
80Galactose metabolism_Homo sapiens_hsa000520.55027844
81Steroid biosynthesis_Homo sapiens_hsa001000.54423870
82Sulfur relay system_Homo sapiens_hsa041220.53051170
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52953420
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52520327
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52362214
86Wnt signaling pathway_Homo sapiens_hsa043100.52268557
87Amoebiasis_Homo sapiens_hsa051460.51639158
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.51580511
89HTLV-I infection_Homo sapiens_hsa051660.51225410
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.51144635
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.50457104
92Herpes simplex infection_Homo sapiens_hsa051680.48767513
93Tight junction_Homo sapiens_hsa045300.47402968
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46522429
95Colorectal cancer_Homo sapiens_hsa052100.46304319
96Parkinsons disease_Homo sapiens_hsa050120.43700504
97Vibrio cholerae infection_Homo sapiens_hsa051100.41035070
98MAPK signaling pathway_Homo sapiens_hsa040100.38241761
99Pathways in cancer_Homo sapiens_hsa052000.37169825
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37160384
101Maturity onset diabetes of the young_Homo sapiens_hsa049500.37115515
102Oxidative phosphorylation_Homo sapiens_hsa001900.35240437
103Pentose phosphate pathway_Homo sapiens_hsa000300.34526004
104Dilated cardiomyopathy_Homo sapiens_hsa054140.33785052
105Lysine degradation_Homo sapiens_hsa003100.33615952
106beta-Alanine metabolism_Homo sapiens_hsa004100.32014333
107Glucagon signaling pathway_Homo sapiens_hsa049220.31742323
108Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.31160684
109Melanoma_Homo sapiens_hsa052180.30467770
110Arginine biosynthesis_Homo sapiens_hsa002200.29430527
111Vitamin digestion and absorption_Homo sapiens_hsa049770.29129081
112Linoleic acid metabolism_Homo sapiens_hsa005910.28921211
113Shigellosis_Homo sapiens_hsa051310.28902832
114Gastric acid secretion_Homo sapiens_hsa049710.28258537
115Lysosome_Homo sapiens_hsa041420.28169241
116Small cell lung cancer_Homo sapiens_hsa052220.27879556
117Legionellosis_Homo sapiens_hsa051340.26021780
118HIF-1 signaling pathway_Homo sapiens_hsa040660.24324841
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.24071381
120Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.22716072
121Huntingtons disease_Homo sapiens_hsa050160.22228513
122Arachidonic acid metabolism_Homo sapiens_hsa005900.21797166
123Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.20547947
124Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.18957687
125alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.16960234
126Metabolic pathways_Homo sapiens_hsa011000.15846275
127Nitrogen metabolism_Homo sapiens_hsa009100.15528939
128PI3K-Akt signaling pathway_Homo sapiens_hsa041510.14702268
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.13498879
130Antigen processing and presentation_Homo sapiens_hsa046120.10506578
131Pyruvate metabolism_Homo sapiens_hsa006200.09745753
132Alcoholism_Homo sapiens_hsa050340.08030739
133Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.06377688
134Acute myeloid leukemia_Homo sapiens_hsa052210.04342145
135Apoptosis_Homo sapiens_hsa042100.03972960
136Thyroid hormone signaling pathway_Homo sapiens_hsa049190.03750136
137Proteoglycans in cancer_Homo sapiens_hsa052050.03050088
138Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.02309687
139AMPK signaling pathway_Homo sapiens_hsa041520.01749470
140Pentose and glucuronate interconversions_Homo sapiens_hsa000400.01196185

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