LEKR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)8.32437474
2cilium or flagellum-dependent cell motility (GO:0001539)8.26750487
3epithelial cilium movement (GO:0003351)7.52054264
4cilium movement (GO:0003341)7.41234240
5fusion of sperm to egg plasma membrane (GO:0007342)7.12471239
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.80258058
7motile cilium assembly (GO:0044458)6.60937483
8sperm motility (GO:0030317)6.26656768
9acrosome assembly (GO:0001675)6.03787003
10cell wall macromolecule catabolic process (GO:0016998)6.00828096
11cell wall macromolecule metabolic process (GO:0044036)6.00828096
12multicellular organism reproduction (GO:0032504)5.87474653
13regulation of cilium movement (GO:0003352)5.63575554
14sperm-egg recognition (GO:0035036)5.49896177
15plasma membrane fusion (GO:0045026)5.44334076
16piRNA metabolic process (GO:0034587)5.40877858
17acrosome reaction (GO:0007340)5.22547730
18male meiosis (GO:0007140)5.22029834
19binding of sperm to zona pellucida (GO:0007339)4.88641332
20intraciliary transport (GO:0042073)4.84513870
21spermatid development (GO:0007286)4.76331402
22cell-cell recognition (GO:0009988)4.73718408
23ventricular system development (GO:0021591)4.58494791
24photoreceptor cell maintenance (GO:0045494)4.52727994
25reproduction (GO:0000003)4.50099287
26protein localization to cilium (GO:0061512)4.40619075
27cellular ketone body metabolic process (GO:0046950)4.36735345
28single fertilization (GO:0007338)4.29903610
29spermatid nucleus differentiation (GO:0007289)4.28611811
30axoneme assembly (GO:0035082)4.23178247
31behavioral response to nicotine (GO:0035095)4.18661154
32sperm capacitation (GO:0048240)4.16783370
33response to pheromone (GO:0019236)4.13090555
34protein K11-linked deubiquitination (GO:0035871)4.08969225
35DNA methylation involved in gamete generation (GO:0043046)4.01989977
36presynaptic membrane assembly (GO:0097105)3.93171978
37ketone body metabolic process (GO:1902224)3.80374075
38synaptonemal complex organization (GO:0070193)3.74766303
39detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.68842082
40cilium morphogenesis (GO:0060271)3.64513939
41response to epinephrine (GO:0071871)3.58467784
42cilium organization (GO:0044782)3.55997300
43indolalkylamine metabolic process (GO:0006586)3.53740617
44tryptophan catabolic process (GO:0006569)3.49849007
45indole-containing compound catabolic process (GO:0042436)3.49849007
46indolalkylamine catabolic process (GO:0046218)3.49849007
47nonmotile primary cilium assembly (GO:0035058)3.49040970
48preassembly of GPI anchor in ER membrane (GO:0016254)3.48694211
49cilium assembly (GO:0042384)3.48192214
50detection of light stimulus involved in visual perception (GO:0050908)3.47085781
51detection of light stimulus involved in sensory perception (GO:0050962)3.47085781
52negative regulation of inclusion body assembly (GO:0090084)3.46352614
53membrane assembly (GO:0071709)3.42647535
54kynurenine metabolic process (GO:0070189)3.40529575
55protein polyglutamylation (GO:0018095)3.40507479
56GTP biosynthetic process (GO:0006183)3.40486383
57calcium ion-dependent exocytosis (GO:0017156)3.38943181
58presynaptic membrane organization (GO:0097090)3.38860852
59fertilization (GO:0009566)3.36444707
60mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.34325417
61retinal cone cell development (GO:0046549)3.31088311
62establishment of protein localization to Golgi (GO:0072600)3.29557304
63regulation of microtubule-based movement (GO:0060632)3.27510603
64synaptonemal complex assembly (GO:0007130)3.26706088
65ATP synthesis coupled proton transport (GO:0015986)3.24671467
66energy coupled proton transport, down electrochemical gradient (GO:0015985)3.24671467
67auditory receptor cell stereocilium organization (GO:0060088)3.23967021
68tryptophan metabolic process (GO:0006568)3.19017609
69photoreceptor cell development (GO:0042461)3.16617469
70regulation of germinal center formation (GO:0002634)3.15514068
71spinal cord motor neuron differentiation (GO:0021522)3.15187734
72centriole replication (GO:0007099)3.14349837
73microtubule bundle formation (GO:0001578)3.13185887
74protein localization to Golgi apparatus (GO:0034067)3.13161218
75mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.10033855
76prenylation (GO:0097354)3.09012221
77protein prenylation (GO:0018342)3.09012221
78cell recognition (GO:0008037)3.08665491
79synapsis (GO:0007129)3.05844124
80cellular component assembly involved in morphogenesis (GO:0010927)3.05212186
81chromosome organization involved in meiosis (GO:0070192)3.02872356
82protein targeting to Golgi (GO:0000042)3.02705785
83respiratory electron transport chain (GO:0022904)3.01733183
84electron transport chain (GO:0022900)3.00898843
85centriole assembly (GO:0098534)2.99806019
86GPI anchor metabolic process (GO:0006505)2.99706398
87neuron cell-cell adhesion (GO:0007158)2.99608818
88negative regulation of nitric-oxide synthase activity (GO:0051001)2.99205427
89negative regulation of mast cell activation (GO:0033004)2.98777936
90somatic diversification of immune receptors via somatic mutation (GO:0002566)2.97642208
91somatic hypermutation of immunoglobulin genes (GO:0016446)2.97642208
92sleep (GO:0030431)2.94026604
93reciprocal meiotic recombination (GO:0007131)2.93388017
94reciprocal DNA recombination (GO:0035825)2.93388017
95nucleoside diphosphate phosphorylation (GO:0006165)2.92671612
96neural tube formation (GO:0001841)2.92632338
97respiratory chain complex IV assembly (GO:0008535)2.92314489
98eye photoreceptor cell development (GO:0042462)2.91724243
99cAMP catabolic process (GO:0006198)2.89129081
100lactate metabolic process (GO:0006089)2.87317007
101spermatogenesis (GO:0007283)2.87141064
102male gamete generation (GO:0048232)2.87074917
103adenosine metabolic process (GO:0046085)2.86761061
104male meiosis I (GO:0007141)2.84440430
105mannosylation (GO:0097502)2.79548193
106neuronal action potential propagation (GO:0019227)2.78949669
107protein localization to synapse (GO:0035418)2.77018058
108inner ear receptor stereocilium organization (GO:0060122)2.75987933
109platelet dense granule organization (GO:0060155)2.74261001
110ATP hydrolysis coupled proton transport (GO:0015991)2.73564276
111energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.73564276
112gamete generation (GO:0007276)2.72344208
113L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.72214636
114indole-containing compound metabolic process (GO:0042430)2.69852238
115retrograde transport, vesicle recycling within Golgi (GO:0000301)2.69843050
116microtubule-based movement (GO:0007018)2.68860209
117UTP biosynthetic process (GO:0006228)2.68759677
118postsynaptic membrane organization (GO:0001941)2.68360421
119cytochrome complex assembly (GO:0017004)2.68275551
120axon ensheathment in central nervous system (GO:0032291)2.67576673
121central nervous system myelination (GO:0022010)2.67576673
122microtubule depolymerization (GO:0007019)2.67478652
123reflex (GO:0060004)2.67195208
124negative regulation of neurotransmitter transport (GO:0051589)2.66607835
125purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.65673928
126signal peptide processing (GO:0006465)2.65141850
127guanosine-containing compound biosynthetic process (GO:1901070)2.65131641
128estrogen biosynthetic process (GO:0006703)2.64494453
129genitalia morphogenesis (GO:0035112)2.64433891
130glycerol ether metabolic process (GO:0006662)2.63159802
131regulation of protein kinase A signaling (GO:0010738)2.63060935
132C-terminal protein lipidation (GO:0006501)2.62828200
133cellular response to epinephrine stimulus (GO:0071872)2.62176661
134meiotic nuclear division (GO:0007126)2.61487406
135germ cell development (GO:0007281)2.61053074
136polyol catabolic process (GO:0046174)2.60187799
137negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.59549786
138cellular biogenic amine catabolic process (GO:0042402)2.58934693
139amine catabolic process (GO:0009310)2.58934693
140benzene-containing compound metabolic process (GO:0042537)2.58364618
141visual perception (GO:0007601)2.58193389
142otic vesicle formation (GO:0030916)2.57946503
143L-fucose catabolic process (GO:0042355)2.57945811
144fucose catabolic process (GO:0019317)2.57945811
145L-fucose metabolic process (GO:0042354)2.57945811
146cellular process involved in reproduction in multicellular organism (GO:0022412)2.56708858
147sensory perception of light stimulus (GO:0050953)2.56666927
148regulation of inclusion body assembly (GO:0090083)2.55579570
149rhodopsin mediated signaling pathway (GO:0016056)2.55130253
150purine nucleoside triphosphate biosynthetic process (GO:0009145)2.54346337
151GPI anchor biosynthetic process (GO:0006506)2.53644074
152left/right axis specification (GO:0070986)2.53526876
153alanine transport (GO:0032328)2.52570482
154left/right pattern formation (GO:0060972)2.50839141
155nucleoside diphosphate catabolic process (GO:0009134)2.50454506
156neuronal action potential (GO:0019228)2.50406010
157negative regulation of synaptic transmission, GABAergic (GO:0032229)2.48787129
158ether metabolic process (GO:0018904)2.48693529
159hydrogen ion transmembrane transport (GO:1902600)2.48260075
160definitive hemopoiesis (GO:0060216)2.47408177
161meiotic cell cycle (GO:0051321)2.47366204
162cell projection assembly (GO:0030031)2.45782267
163ATP biosynthetic process (GO:0006754)2.44298940
164cyclic nucleotide catabolic process (GO:0009214)2.43523337
165primary amino compound metabolic process (GO:1901160)2.42770906
166C-terminal protein amino acid modification (GO:0018410)2.39507924
167positive regulation of prostaglandin secretion (GO:0032308)2.37788935
168DNA deamination (GO:0045006)2.37314263
169organic cation transport (GO:0015695)2.37216074

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.45690886
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.03185638
3GBX2_23144817_ChIP-Seq_PC3_Human3.67618703
4TAF15_26573619_Chip-Seq_HEK293_Human3.26454022
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.14076314
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.99134136
7FUS_26573619_Chip-Seq_HEK293_Human2.75827327
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.53811559
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.44715191
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.37654029
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.35805193
12VDR_22108803_ChIP-Seq_LS180_Human2.32706050
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.26473783
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.18995589
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.18346762
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.16610144
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06352877
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.05611196
19IGF1R_20145208_ChIP-Seq_DFB_Human2.02238275
20EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.01958795
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.92566211
22ZNF274_21170338_ChIP-Seq_K562_Hela1.92172415
23RNF2_27304074_Chip-Seq_NSC_Mouse1.91301126
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90730474
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.87152373
26* P300_19829295_ChIP-Seq_ESCs_Human1.81651072
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.80232639
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73818157
29* SMAD4_21799915_ChIP-Seq_A2780_Human1.69772052
30RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.63382669
31ER_23166858_ChIP-Seq_MCF-7_Human1.63377250
32BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.63136616
33EWS_26573619_Chip-Seq_HEK293_Human1.63042987
34TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.57819209
35* NANOG_18555785_Chip-Seq_ESCs_Mouse1.56243665
36TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54514628
37EGR1_23403033_ChIP-Seq_LIVER_Mouse1.53954035
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53706890
39SMAD3_21741376_ChIP-Seq_EPCs_Human1.53081859
40SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52987630
41* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.52672483
42AR_21572438_ChIP-Seq_LNCaP_Human1.51634626
43TAL1_26923725_Chip-Seq_HPCs_Mouse1.50585441
44* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49861251
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.48064522
46OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47916263
47SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.45004534
48* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44291433
49EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.42845219
50* FOXA1_25329375_ChIP-Seq_VCAP_Human1.42492407
51* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.42492407
52REST_21632747_ChIP-Seq_MESCs_Mouse1.42449993
53* P53_22387025_ChIP-Seq_ESCs_Mouse1.41613580
54* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40604098
55TP53_22573176_ChIP-Seq_HFKS_Human1.39531417
56ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37976146
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36892354
58GABP_17652178_ChIP-ChIP_JURKAT_Human1.34558970
59* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.34276234
60IRF8_22096565_ChIP-ChIP_GC-B_Human1.33971885
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31847582
62TCF4_23295773_ChIP-Seq_U87_Human1.30980940
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30270186
64TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30270186
65SUZ12_18555785_Chip-Seq_ESCs_Mouse1.29063811
66* SOX2_19829295_ChIP-Seq_ESCs_Human1.28849941
67* NANOG_19829295_ChIP-Seq_ESCs_Human1.28849941
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28286941
69CBP_20019798_ChIP-Seq_JUKART_Human1.28286941
70TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28214615
71* GATA3_21878914_ChIP-Seq_MCF-7_Human1.27597523
72TCF4_22108803_ChIP-Seq_LS180_Human1.27194481
73CMYC_18555785_Chip-Seq_ESCs_Mouse1.27069254
74KDM2B_26808549_Chip-Seq_REH_Human1.25237479
75MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.24545914
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24507008
77* E2F1_18555785_Chip-Seq_ESCs_Mouse1.24307450
78AR_20517297_ChIP-Seq_VCAP_Human1.24252820
79NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23996671
80P300_18555785_Chip-Seq_ESCs_Mouse1.23891565
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.23271356
82STAT3_18555785_Chip-Seq_ESCs_Mouse1.23209958
83EZH2_27304074_Chip-Seq_ESCs_Mouse1.22661068
84MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22142754
85SMAD4_21741376_ChIP-Seq_EPCs_Human1.21487249
86CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21202387
87* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20620738
88SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.20458744
89EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.19738223
90* STAT3_23295773_ChIP-Seq_U87_Human1.19062224
91BCAT_22108803_ChIP-Seq_LS180_Human1.18864909
92KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.18460665
93PIAS1_25552417_ChIP-Seq_VCAP_Human1.18394657
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17896370
95TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.17777554
96NCOR_22424771_ChIP-Seq_293T_Human1.16854810
97SALL1_21062744_ChIP-ChIP_HESCs_Human1.16691097
98NFE2_27457419_Chip-Seq_LIVER_Mouse1.15826130
99EZH2_27294783_Chip-Seq_NPCs_Mouse1.15770402
100SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.15674804
101CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13984367
102ERG_20517297_ChIP-Seq_VCAP_Human1.13312156
103MYC_18940864_ChIP-ChIP_HL60_Human1.13219323
104KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12911823
105JARID2_20064375_ChIP-Seq_MESCs_Mouse1.12655525
106PRDM14_20953172_ChIP-Seq_ESCs_Human1.12600920
107* RUNX2_22187159_ChIP-Seq_PCA_Human1.11437402
108FLI1_21867929_ChIP-Seq_TH2_Mouse1.11179971
109KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.11033916
110SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.10389744
111SOX2_18555785_Chip-Seq_ESCs_Mouse1.10288306
112PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09659356
113OCT4_18555785_Chip-Seq_ESCs_Mouse1.09502307
114FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08831801
115RUNX1_27457419_Chip-Seq_LIVER_Mouse1.08545285
116WT1_19549856_ChIP-ChIP_CCG9911_Human1.08080756
117HOXB7_26014856_ChIP-Seq_BT474_Human1.06767244
118CDX2_22108803_ChIP-Seq_LS180_Human1.06256442
119CRX_20693478_ChIP-Seq_RETINA_Mouse1.05469978
120* AR_25329375_ChIP-Seq_VCAP_Human1.05136397
121NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05131523
122NMYC_18555785_Chip-Seq_ESCs_Mouse1.04971257
123* SOX9_26525672_Chip-Seq_HEART_Mouse1.04441174
124FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04406013
125OCT4_21477851_ChIP-Seq_ESCs_Mouse1.04228039
126SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03659268
127ELK1_19687146_ChIP-ChIP_HELA_Human1.03327119
128JUN_21703547_ChIP-Seq_K562_Human1.03220684
129EED_16625203_ChIP-ChIP_MESCs_Mouse1.01513679
130TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01362683
131IRF1_19129219_ChIP-ChIP_H3396_Human1.01028406
132EZH2_27294783_Chip-Seq_ESCs_Mouse1.00057330
133GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99862668
134GATA3_26560356_Chip-Seq_TH2_Human0.99024817
135PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99004668
136VDR_23849224_ChIP-Seq_CD4+_Human0.98929981
137FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97665671
138CEBPB_22108803_ChIP-Seq_LS180_Human0.97028170
139ETV1_20927104_ChIP-Seq_GIST48_Human0.96593267
140SMRT_27268052_Chip-Seq_Bcells_Human0.96212934
141ARNT_22903824_ChIP-Seq_MCF-7_Human0.94038667

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.54611222
2MP0003950_abnormal_plasma_membrane3.72036308
3MP0009780_abnormal_chondrocyte_physiolo3.56379072
4MP0001188_hyperpigmentation3.17563390
5MP0003880_abnormal_central_pattern3.14701179
6MP0004147_increased_porphyrin_level3.06303689
7MP0000569_abnormal_digit_pigmentation3.02596677
8MP0008875_abnormal_xenobiotic_pharmacok2.91274547
9MP0008877_abnormal_DNA_methylation2.66879013
10MP0001986_abnormal_taste_sensitivity2.65433507
11MP0003195_calcinosis2.54763728
12MP0005171_absent_coat_pigmentation2.49377810
13MP0003698_abnormal_male_reproductive2.44413716
14MP0005409_darkened_coat_color2.37585467
15MP0001984_abnormal_olfaction2.37185599
16MP0002138_abnormal_hepatobiliary_system2.22772079
17MP0009046_muscle_twitch2.21588085
18MP0001929_abnormal_gametogenesis2.06378675
19MP0002638_abnormal_pupillary_reflex2.04474789
20MP0000015_abnormal_ear_pigmentation2.02495950
21MP0002102_abnormal_ear_morphology2.01413047
22MP0004859_abnormal_synaptic_plasticity2.01288207
23MP0001529_abnormal_vocalization1.92758227
24MP0002876_abnormal_thyroid_physiology1.91053372
25MP0001486_abnormal_startle_reflex1.86502437
26MP0004270_analgesia1.85904968
27MP0005645_abnormal_hypothalamus_physiol1.84711779
28MP0003635_abnormal_synaptic_transmissio1.80570359
29MP0003011_delayed_dark_adaptation1.75784052
30MP0009745_abnormal_behavioral_response1.73736888
31MP0002272_abnormal_nervous_system1.73505543
32MP0002064_seizures1.70014601
33MP0005646_abnormal_pituitary_gland1.67016066
34MP0002734_abnormal_mechanical_nocicepti1.64627411
35MP0001968_abnormal_touch/_nociception1.61858919
36MP0000383_abnormal_hair_follicle1.60200775
37MP0002572_abnormal_emotion/affect_behav1.59875786
38MP0005310_abnormal_salivary_gland1.56631853
39MP0001905_abnormal_dopamine_level1.55135433
40MP0008995_early_reproductive_senescence1.55061886
41MP0002736_abnormal_nociception_after1.54831555
42MP0004142_abnormal_muscle_tone1.51627286
43MP0000681_abnormal_thyroid_gland1.49992051
44MP0005174_abnormal_tail_pigmentation1.49672214
45MP0001485_abnormal_pinna_reflex1.48792526
46MP0005551_abnormal_eye_electrophysiolog1.48156994
47MP0001764_abnormal_homeostasis1.48092856
48MP0003136_yellow_coat_color1.44379425
49MP0008872_abnormal_physiological_respon1.44145839
50MP0002210_abnormal_sex_determination1.43662253
51MP0002928_abnormal_bile_duct1.43575530
52MP0008789_abnormal_olfactory_epithelium1.42807929
53MP0003191_abnormal_cellular_cholesterol1.42194999
54MP0002063_abnormal_learning/memory/cond1.39651623
55MP0002735_abnormal_chemical_nociception1.36720107
56MP0002067_abnormal_sensory_capabilities1.36623461
57MP0008057_abnormal_DNA_replication1.31332189
58MP0006138_congestive_heart_failure1.31039366
59MP0002009_preneoplasia1.30690987
60MP0009379_abnormal_foot_pigmentation1.29667482
61MP0001879_abnormal_lymphatic_vessel1.28605554
62MP0003787_abnormal_imprinting1.28065095
63MP0004233_abnormal_muscle_weight1.27743671
64MP0000427_abnormal_hair_cycle1.27206304
65MP0006072_abnormal_retinal_apoptosis1.26399751
66MP0002332_abnormal_exercise_endurance1.23297050
67MP0005083_abnormal_biliary_tract1.23285808
68MP0003122_maternal_imprinting1.22803694
69MP0005075_abnormal_melanosome_morpholog1.21751224
70MP0003718_maternal_effect1.21477149
71MP0002938_white_spotting1.21454698
72MP0002161_abnormal_fertility/fecundity1.20775083
73MP0003724_increased_susceptibility_to1.20740658
74MP0000920_abnormal_myelination1.19503096
75MP0002163_abnormal_gland_morphology1.18247483
76MP0004133_heterotaxia1.17598591
77MP0000631_abnormal_neuroendocrine_gland1.17211838
78MP0004043_abnormal_pH_regulation1.16996929
79MP0002653_abnormal_ependyma_morphology1.15830229
80MP0001501_abnormal_sleep_pattern1.15180560
81MP0003123_paternal_imprinting1.12883682
82MP0004742_abnormal_vestibular_system1.11985567
83MP0003121_genomic_imprinting1.11180580
84MP0002557_abnormal_social/conspecific_i1.10547022
85MP0005379_endocrine/exocrine_gland_phen1.09606045
86MP0001145_abnormal_male_reproductive1.09096682
87MP0005389_reproductive_system_phenotype1.09087306
88MP0006292_abnormal_olfactory_placode1.06344177
89MP0003828_pulmonary_edema1.05799830
90MP0009697_abnormal_copulation1.05121497
91MP0000778_abnormal_nervous_system1.04927178
92MP0002254_reproductive_system_inflammat1.04373136
93MP0005391_vision/eye_phenotype1.04003671
94MP0000372_irregular_coat_pigmentation1.01698304
95MP0003646_muscle_fatigue1.01437347
96MP0008058_abnormal_DNA_repair0.99289874
97MP0002229_neurodegeneration0.98816234
98MP0001765_abnormal_ion_homeostasis0.97518008
99MP0000653_abnormal_sex_gland0.96809503
100MP0005195_abnormal_posterior_eye0.96186895
101MP0005365_abnormal_bile_salt0.94861241
102MP0005332_abnormal_amino_acid0.94765855
103MP0002160_abnormal_reproductive_system0.94597650
104MP0002090_abnormal_vision0.93109679
105MP0008569_lethality_at_weaning0.92955643
106MP0000230_abnormal_systemic_arterial0.92400146
107MP0002095_abnormal_skin_pigmentation0.92313934
108MP0005085_abnormal_gallbladder_physiolo0.91414454
109MP0004019_abnormal_vitamin_homeostasis0.91277072
110MP0001963_abnormal_hearing_physiology0.90565334
111MP0003252_abnormal_bile_duct0.90190788
112MP0004885_abnormal_endolymph0.89911162
113MP0005499_abnormal_olfactory_system0.89000548
114MP0005394_taste/olfaction_phenotype0.89000548
115MP0001873_stomach_inflammation0.88984214
116MP0010678_abnormal_skin_adnexa0.88878879
117MP0001970_abnormal_pain_threshold0.87651129
118MP0006054_spinal_hemorrhage0.86552641
119MP0005253_abnormal_eye_physiology0.86523843
120MP0006276_abnormal_autonomic_nervous0.85434664
121MP0002184_abnormal_innervation0.84145205
122MP0000955_abnormal_spinal_cord0.83925738
123MP0005084_abnormal_gallbladder_morpholo0.83499433
124MP0004215_abnormal_myocardial_fiber0.80497570
125MP0005220_abnormal_exocrine_pancreas0.80431012
126MP0001919_abnormal_reproductive_system0.79060416
127MP0010329_abnormal_lipoprotein_level0.78900913
128MP0004134_abnormal_chest_morphology0.78639665
129MP0002882_abnormal_neuron_morphology0.76896214
130MP0005388_respiratory_system_phenotype0.76762118
131MP0002133_abnormal_respiratory_system0.76762118
132MP0006036_abnormal_mitochondrial_physio0.76615625
133MP0001324_abnormal_eye_pigmentation0.76234839
134MP0001664_abnormal_digestion0.76220597
135MP0005636_abnormal_mineral_homeostasis0.76118451
136MP0005386_behavior/neurological_phenoty0.75815791
137MP0004924_abnormal_behavior0.75815791
138MP0001440_abnormal_grooming_behavior0.75525119
139MP0005423_abnormal_somatic_nervous0.75225704
140MP0002837_dystrophic_cardiac_calcinosis0.75138033
141MP0005395_other_phenotype0.75081944
142MP0004484_altered_response_of0.74734268
143MP0001944_abnormal_pancreas_morphology0.74023380
144MP0000026_abnormal_inner_ear0.73497632
145MP0003634_abnormal_glial_cell0.72567085
146MP0003690_abnormal_glial_cell0.70686971
147MP0002752_abnormal_somatic_nervous0.70677353
148MP0002177_abnormal_outer_ear0.70297971
149MP0002066_abnormal_motor_capabilities/c0.68169102

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.33089925
2Dynein arm defect of respiratory motile cilia (HP:0012255)8.39919287
3Absent/shortened dynein arms (HP:0200106)8.39919287
4Abnormal respiratory motile cilium physiology (HP:0012261)7.47520899
5Abnormal ciliary motility (HP:0012262)6.99551799
6Abnormal respiratory epithelium morphology (HP:0012253)6.48836175
7Abnormal respiratory motile cilium morphology (HP:0005938)6.48836175
8Rhinitis (HP:0012384)5.33971177
9Chronic bronchitis (HP:0004469)4.49041092
10Medial flaring of the eyebrow (HP:0010747)4.30278691
11Molar tooth sign on MRI (HP:0002419)3.65971120
12Abnormality of midbrain morphology (HP:0002418)3.65971120
13Pancreatic fibrosis (HP:0100732)3.60361451
14Congenital stationary night blindness (HP:0007642)3.56623985
15Attenuation of retinal blood vessels (HP:0007843)3.56151738
16Gait imbalance (HP:0002141)3.53363315
17Congenital primary aphakia (HP:0007707)3.51066636
18Nephronophthisis (HP:0000090)3.40709065
19Infertility (HP:0000789)3.33132195
20Bronchiectasis (HP:0002110)3.31884584
21Nephrogenic diabetes insipidus (HP:0009806)3.31173632
22Decreased central vision (HP:0007663)3.29142189
23True hermaphroditism (HP:0010459)3.25479421
24Bony spicule pigmentary retinopathy (HP:0007737)3.18987860
25Abnormal rod and cone electroretinograms (HP:0008323)3.09778344
26Tubular atrophy (HP:0000092)2.86890133
27Vaginal atresia (HP:0000148)2.86809697
28Genital tract atresia (HP:0001827)2.83635057
29Abnormality of the renal medulla (HP:0100957)2.79717812
30Tubulointerstitial nephritis (HP:0001970)2.79427447
31Absent rod-and cone-mediated responses on ERG (HP:0007688)2.73022616
32Acute necrotizing encephalopathy (HP:0006965)2.70824507
33Atonic seizures (HP:0010819)2.68007447
34Hyperventilation (HP:0002883)2.65633607
35Focal motor seizures (HP:0011153)2.63852564
36Renal cortical cysts (HP:0000803)2.63813804
37Retinal dysplasia (HP:0007973)2.62699824
38Nasal polyposis (HP:0100582)2.57979507
39Poor coordination (HP:0002370)2.57580973
40Pancreatic cysts (HP:0001737)2.57081563
41Abnormal drinking behavior (HP:0030082)2.52351051
42Polydipsia (HP:0001959)2.52351051
43Bronchitis (HP:0012387)2.48334578
44Decreased circulating renin level (HP:0003351)2.46401856
45Recurrent sinusitis (HP:0011108)2.44537443
46Epileptic encephalopathy (HP:0200134)2.41534763
47Abnormal mitochondria in muscle tissue (HP:0008316)2.40868595
48Type II lissencephaly (HP:0007260)2.38035836
49Mitochondrial inheritance (HP:0001427)2.32632545
50Progressive macrocephaly (HP:0004481)2.32159280
51Supernumerary spleens (HP:0009799)2.31040184
52Hypothermia (HP:0002045)2.28633339
53Ependymoma (HP:0002888)2.27753107
54Aplasia/Hypoplasia of the lens (HP:0008063)2.25209669
55Abnormal hair whorl (HP:0010721)2.23042245
56Abnormality of the nasal mucosa (HP:0000433)2.16975868
57Postaxial foot polydactyly (HP:0001830)2.11124983
58Hyperkalemia (HP:0002153)2.09808510
59Acute encephalopathy (HP:0006846)2.08245975
60Congenital hepatic fibrosis (HP:0002612)2.07009057
61Methylmalonic acidemia (HP:0002912)2.06857867
62Decreased electroretinogram (ERG) amplitude (HP:0000654)2.06452162
63Occipital encephalocele (HP:0002085)2.05890830
64Xerostomia (HP:0000217)2.05812312
65Postaxial hand polydactyly (HP:0001162)2.03960124
66Abnormality of macular pigmentation (HP:0008002)2.03453482
67Gaze-evoked nystagmus (HP:0000640)2.01542345
68Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.98704497
69Abnormality of alanine metabolism (HP:0010916)1.98704497
70Hyperalaninemia (HP:0003348)1.98704497
71Male pseudohermaphroditism (HP:0000037)1.97957410
72Increased CSF lactate (HP:0002490)1.97597888
73Optic disc pallor (HP:0000543)1.94924351
74White forelock (HP:0002211)1.94504067
75Increased hepatocellular lipid droplets (HP:0006565)1.94098112
76Aplasia/Hypoplasia of the tongue (HP:0010295)1.93138652
77Severe visual impairment (HP:0001141)1.90468848
78Broad foot (HP:0001769)1.90450295
79Stomach cancer (HP:0012126)1.89359992
80Abnormal biliary tract physiology (HP:0012439)1.88569499
81Bile duct proliferation (HP:0001408)1.88569499
82Chronic sinusitis (HP:0011109)1.86951520
83Constricted visual fields (HP:0001133)1.86672250
84Polyuria (HP:0000103)1.84790104
85Progressive inability to walk (HP:0002505)1.84616082
86Congenital, generalized hypertrichosis (HP:0004540)1.83438665
87Patchy hypopigmentation of hair (HP:0011365)1.83304608
88Renal Fanconi syndrome (HP:0001994)1.83010447
89Oculomotor apraxia (HP:0000657)1.82890891
903-Methylglutaconic aciduria (HP:0003535)1.82036545
91Biliary tract neoplasm (HP:0100574)1.79894686
92Furrowed tongue (HP:0000221)1.79678077
93Abnormality of the astrocytes (HP:0100707)1.79411080
94Astrocytoma (HP:0009592)1.79411080
95Congenital sensorineural hearing impairment (HP:0008527)1.78620163
96Dialeptic seizures (HP:0011146)1.78196623
97Fair hair (HP:0002286)1.78101241
98Fibular hypoplasia (HP:0003038)1.77655424
99Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.77197229
100Degeneration of the lateral corticospinal tracts (HP:0002314)1.77197229
101Abnormality of renal resorption (HP:0011038)1.75671861
102Pendular nystagmus (HP:0012043)1.75301076
103Azoospermia (HP:0000027)1.74645758
104Hypoplasia of the fovea (HP:0007750)1.74445584
105Aplasia/Hypoplasia of the fovea (HP:0008060)1.74445584
106Abnormality of glycolysis (HP:0004366)1.73913630
107Increased serum pyruvate (HP:0003542)1.73913630
108Chronic hepatic failure (HP:0100626)1.73823616
109Nasolacrimal duct obstruction (HP:0000579)1.72929877
110Aplasia/Hypoplasia of the tibia (HP:0005772)1.72928070
111Tubulointerstitial abnormality (HP:0001969)1.72435288
112Median cleft lip (HP:0000161)1.70578989
113Limb dystonia (HP:0002451)1.70361861
114Abnormality of the renal cortex (HP:0011035)1.70077228
115Clumsiness (HP:0002312)1.68883887
116Aganglionic megacolon (HP:0002251)1.68680679
117Hypokalemic alkalosis (HP:0001949)1.68341995
118Progressive cerebellar ataxia (HP:0002073)1.67061799
119Abnormal spermatogenesis (HP:0008669)1.66327363
120Neonatal respiratory distress (HP:0002643)1.65855367
121Widely spaced teeth (HP:0000687)1.65240400
122Dyschromatopsia (HP:0007641)1.63712771
123Cystic liver disease (HP:0006706)1.62862821
124Macular degeneration (HP:0000608)1.62349753
125Febrile seizures (HP:0002373)1.61606711
126Hepatocellular necrosis (HP:0001404)1.61105174
127Absence seizures (HP:0002121)1.60881830
128Abnormal number of erythroid precursors (HP:0012131)1.60645444
129Preaxial hand polydactyly (HP:0001177)1.60284892
130Nephropathy (HP:0000112)1.59765858
131Sensory axonal neuropathy (HP:0003390)1.58130623
132Anencephaly (HP:0002323)1.57935448
133Short tibia (HP:0005736)1.57838200
134Renal dysplasia (HP:0000110)1.57152730
135Sclerocornea (HP:0000647)1.56202660
136Leukodystrophy (HP:0002415)1.54619176
137Lipid accumulation in hepatocytes (HP:0006561)1.54555377
138Stage 5 chronic kidney disease (HP:0003774)1.54494793
139Poor speech (HP:0002465)1.53624913
140Respiratory difficulties (HP:0002880)1.52887253
141Retinitis pigmentosa (HP:0000510)1.52244341
142Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.52142995
143Exercise intolerance (HP:0003546)1.52054989
144Abolished electroretinogram (ERG) (HP:0000550)1.51694609

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.47787285
2CASK3.91278127
3PDK33.85471957
4PDK43.85471957
5MAP4K23.71262179
6TNIK3.57566990
7BMPR1B3.56000235
8STK393.44225722
9ZAK3.05888843
10TLK12.93736283
11PRPF4B2.87236649
12PDK22.53977593
13STK162.44241465
14MAP3K122.39559744
15INSRR2.31965914
16MAP2K72.28636769
17WNK42.26770260
18PTK2B2.09694276
19MKNK21.93699282
20BCR1.88881903
21MAPK151.86108872
22OXSR11.76223508
23IKBKB1.75047600
24TRPM71.72538924
25EPHA41.71464042
26IRAK11.70980426
27PINK11.69196624
28CDK191.67267452
29ACVR1B1.65986110
30TRIM281.63791057
31WNK31.62893617
32MST41.62523797
33NTRK31.55955869
34NEK61.53993144
35MAPKAPK31.49185775
36TXK1.46936945
37PNCK1.43087084
38MKNK11.42942432
39VRK11.38949126
40MAP2K21.38307464
41MUSK1.35180396
42STK38L1.30404113
43YES11.29914200
44PLK21.27476108
45BMPR21.26301514
46MAPK131.15117892
47MAP3K41.14899867
48TAOK31.10219929
49LATS11.08969276
50MYLK1.07224720
51DAPK21.02751137
52BLK1.01447087
53MAPKAPK50.96588657
54TNK20.96491584
55MAPK110.96012718
56WNK10.94075357
57DAPK10.93680259
58BRSK20.92983719
59TEC0.92428253
60NEK90.91881131
61TGFBR10.90366192
62TIE10.88757825
63MAP3K140.88571151
64PIK3CG0.88251502
65RIPK40.87035462
66IKBKE0.85596310
67PHKG20.82889507
68PHKG10.82889507
69CAMK2A0.81556270
70AKT30.79360325
71DYRK30.78940555
72TAOK20.78243042
73RPS6KA50.77583088
74STK380.76822865
75NUAK10.76275296
76NME10.75874818
77SRPK10.75817157
78BCKDK0.74441231
79FES0.72440400
80STK30.70903642
81ADRBK20.69571149
82SIK30.69554226
83PASK0.69294405
84MINK10.68942518
85CHUK0.68527636
86CAMK2B0.66951228
87WEE10.66708157
88PAK30.66039132
89CSNK1D0.61970918
90PRKAA20.60074753
91CAMK2D0.59882706
92TBK10.56496736
93EPHA30.56135289
94LMTK20.55323487
95ICK0.54798536
96PRKCG0.54563731
97PRKD30.53849249
98EIF2AK20.52974007
99MAP2K60.52270185
100CDK30.49321949
101PRKAA10.49196678
102PRKCE0.48913844
103PRKCQ0.48856693
104CDK50.48379559
105CCNB10.48115852
106CAMKK20.46837184
107ROCK20.45728517
108KIT0.44345160
109CSNK1G30.43061538
110PIM10.42287283
111PDK10.42162433
112SYK0.41198114
113ABL10.40929041
114GRK50.40798462
115PRKCA0.40790219
116ERBB30.40191906
117RPS6KA60.40154995
118STK110.40044593
119EIF2AK30.39439858
120PLK40.39060349
121MAP2K10.39052630
122GRK70.37286996
123MAP3K70.36817160
124BRAF0.36632289
125MAP3K60.36158155
126CDK90.34706530
127MARK30.33143296
128CSNK1G20.32487508
129ITK0.32349022
130CAMK10.31802710
131FGR0.31770471
132FLT30.31422156
133PRKG10.30797694
134CSNK1A1L0.30026029
135EPHB10.29373003
136PRKACA0.29262382
137UHMK10.27643903
138PRKACB0.26837062
139GRK10.25476215
140MAP2K40.25174832
141FER0.23408479
142ADRBK10.23380765
143RAF10.22903251
144CDC70.22007181
145DYRK1A0.20345236
146CAMK2G0.19894141
147PKN10.19833694
148CSNK2A10.19737860
149FYN0.19165368
150MAP3K130.17628614

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.82114366
2Parkinsons disease_Homo sapiens_hsa050123.08691634
3Huntingtons disease_Homo sapiens_hsa050162.98781615
4Protein export_Homo sapiens_hsa030602.92443427
5Nicotine addiction_Homo sapiens_hsa050332.80664790
6Alzheimers disease_Homo sapiens_hsa050102.65097430
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.39856806
8Butanoate metabolism_Homo sapiens_hsa006502.30766069
9Olfactory transduction_Homo sapiens_hsa047402.24702685
10Nitrogen metabolism_Homo sapiens_hsa009102.13568448
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.08374918
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.99471610
13Selenocompound metabolism_Homo sapiens_hsa004501.99051668
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.98979825
15Amphetamine addiction_Homo sapiens_hsa050311.98520493
16Cardiac muscle contraction_Homo sapiens_hsa042601.95545231
17Asthma_Homo sapiens_hsa053101.92654837
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.90473348
19Basal transcription factors_Homo sapiens_hsa030221.89830704
20Phototransduction_Homo sapiens_hsa047441.89461363
21Collecting duct acid secretion_Homo sapiens_hsa049661.78801771
22Circadian entrainment_Homo sapiens_hsa047131.77942323
23Tryptophan metabolism_Homo sapiens_hsa003801.76600190
24Glutamatergic synapse_Homo sapiens_hsa047241.75893699
25Morphine addiction_Homo sapiens_hsa050321.71349405
26Propanoate metabolism_Homo sapiens_hsa006401.71065161
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.69175887
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.64720157
29Long-term potentiation_Homo sapiens_hsa047201.64709552
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.62850259
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.61522692
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.59485473
33Chemical carcinogenesis_Homo sapiens_hsa052041.58377812
34Serotonergic synapse_Homo sapiens_hsa047261.58132482
35Taste transduction_Homo sapiens_hsa047421.55168725
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.54396577
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.53147643
38Fatty acid elongation_Homo sapiens_hsa000621.52516213
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.50312601
40Synaptic vesicle cycle_Homo sapiens_hsa047211.48227597
41Dopaminergic synapse_Homo sapiens_hsa047281.46297683
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.45894784
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.45855246
44Sulfur metabolism_Homo sapiens_hsa009201.43673077
45Vibrio cholerae infection_Homo sapiens_hsa051101.38369116
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37316084
47GABAergic synapse_Homo sapiens_hsa047271.36459803
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.34560212
49Pyruvate metabolism_Homo sapiens_hsa006201.34189644
50Fanconi anemia pathway_Homo sapiens_hsa034601.32892490
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.31801199
52ABC transporters_Homo sapiens_hsa020101.31648037
53Type I diabetes mellitus_Homo sapiens_hsa049401.30395820
54Renin secretion_Homo sapiens_hsa049241.26343553
55Calcium signaling pathway_Homo sapiens_hsa040201.26077260
56Homologous recombination_Homo sapiens_hsa034401.24347634
57Insulin secretion_Homo sapiens_hsa049111.24127385
58Long-term depression_Homo sapiens_hsa047301.21599191
59Proteasome_Homo sapiens_hsa030501.20321529
60Graft-versus-host disease_Homo sapiens_hsa053321.19797943
61Caffeine metabolism_Homo sapiens_hsa002321.18588606
62beta-Alanine metabolism_Homo sapiens_hsa004101.18271517
63Retinol metabolism_Homo sapiens_hsa008301.17186056
64Purine metabolism_Homo sapiens_hsa002301.15412516
65Peroxisome_Homo sapiens_hsa041461.15358523
66Sphingolipid metabolism_Homo sapiens_hsa006001.14147793
67Autoimmune thyroid disease_Homo sapiens_hsa053201.10648791
68N-Glycan biosynthesis_Homo sapiens_hsa005101.08324129
69Vitamin B6 metabolism_Homo sapiens_hsa007501.07193828
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.06480955
71Allograft rejection_Homo sapiens_hsa053301.06454870
72Ether lipid metabolism_Homo sapiens_hsa005651.05137698
73RNA polymerase_Homo sapiens_hsa030201.02676019
74Salivary secretion_Homo sapiens_hsa049701.01163787
75Fatty acid biosynthesis_Homo sapiens_hsa000611.00659157
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97003415
77Rheumatoid arthritis_Homo sapiens_hsa053230.93526584
78Primary immunodeficiency_Homo sapiens_hsa053400.91415098
79Systemic lupus erythematosus_Homo sapiens_hsa053220.90967371
80Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.87467685
81Ribosome_Homo sapiens_hsa030100.86762269
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86755006
83RNA degradation_Homo sapiens_hsa030180.85743378
84Histidine metabolism_Homo sapiens_hsa003400.77820073
85Nucleotide excision repair_Homo sapiens_hsa034200.76727861
86Axon guidance_Homo sapiens_hsa043600.76027211
87Glucagon signaling pathway_Homo sapiens_hsa049220.75786444
88Cholinergic synapse_Homo sapiens_hsa047250.75108054
89cAMP signaling pathway_Homo sapiens_hsa040240.74803756
90One carbon pool by folate_Homo sapiens_hsa006700.72583581
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70455160
92Oocyte meiosis_Homo sapiens_hsa041140.70126513
93Cocaine addiction_Homo sapiens_hsa050300.70033623
94Circadian rhythm_Homo sapiens_hsa047100.68597752
95Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68509639
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.67072994
97Ras signaling pathway_Homo sapiens_hsa040140.66358875
98Glutathione metabolism_Homo sapiens_hsa004800.65727731
99Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.64663243
100Pyrimidine metabolism_Homo sapiens_hsa002400.63855701
101Regulation of autophagy_Homo sapiens_hsa041400.63236586
102Ovarian steroidogenesis_Homo sapiens_hsa049130.60752478
103Alcoholism_Homo sapiens_hsa050340.60690001
104Oxytocin signaling pathway_Homo sapiens_hsa049210.60494356
105Fatty acid metabolism_Homo sapiens_hsa012120.60154012
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58574763
107Glycerolipid metabolism_Homo sapiens_hsa005610.57962167
108Gastric acid secretion_Homo sapiens_hsa049710.57892913
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57633701
110Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57290525
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56640339
112Phenylalanine metabolism_Homo sapiens_hsa003600.56058999
113Non-homologous end-joining_Homo sapiens_hsa034500.55367928
114Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54777025
115Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54757975
116Metabolic pathways_Homo sapiens_hsa011000.54750316
117Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54019172
118Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54013009
119Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51928531
120Phagosome_Homo sapiens_hsa041450.51808491
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51543159
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.49260580
123Fatty acid degradation_Homo sapiens_hsa000710.48898365
124NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48101213
125Tyrosine metabolism_Homo sapiens_hsa003500.47226157
126DNA replication_Homo sapiens_hsa030300.45221833
127Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43785793
128Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43542875
129Mismatch repair_Homo sapiens_hsa034300.42436544
130Cysteine and methionine metabolism_Homo sapiens_hsa002700.42294709
131Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42119408
132Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39701439
133Pancreatic secretion_Homo sapiens_hsa049720.39698240
134Arachidonic acid metabolism_Homo sapiens_hsa005900.38852669
135Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38036094
136Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34525595
137Linoleic acid metabolism_Homo sapiens_hsa005910.33326936
138Thyroid hormone synthesis_Homo sapiens_hsa049180.30991931
139Melanoma_Homo sapiens_hsa052180.29798667
140MAPK signaling pathway_Homo sapiens_hsa040100.28968884
141Dorso-ventral axis formation_Homo sapiens_hsa043200.28266281
142Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27722808
143Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27007383
144Steroid biosynthesis_Homo sapiens_hsa001000.25581997
145Melanogenesis_Homo sapiens_hsa049160.24558579
146Spliceosome_Homo sapiens_hsa030400.23213117
147Gap junction_Homo sapiens_hsa045400.23058931
148Rap1 signaling pathway_Homo sapiens_hsa040150.22809746
149Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.21372845
150Mineral absorption_Homo sapiens_hsa049780.20404684
151Sphingolipid signaling pathway_Homo sapiens_hsa040710.20146848

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