LEMD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)4.81908861
2nucleobase catabolic process (GO:0046113)4.71671145
3microtubule depolymerization (GO:0007019)4.34112451
4retinal ganglion cell axon guidance (GO:0031290)4.24902058
5nonmotile primary cilium assembly (GO:0035058)4.18961927
6intraciliary transport (GO:0042073)4.16667091
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.08932057
8protein polyglutamylation (GO:0018095)4.01025716
9establishment of mitochondrion localization (GO:0051654)3.89199097
10vocalization behavior (GO:0071625)3.83434308
11neuron cell-cell adhesion (GO:0007158)3.81383917
12acrosome reaction (GO:0007340)3.80021580
13sequestering of actin monomers (GO:0042989)3.78170683
14substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.75165647
15substrate-independent telencephalic tangential migration (GO:0021826)3.75165647
16positive regulation of growth hormone secretion (GO:0060124)3.65010538
17startle response (GO:0001964)3.62949493
18urinary tract smooth muscle contraction (GO:0014848)3.60937693
19paraxial mesoderm development (GO:0048339)3.56699560
20negative regulation of transcription regulatory region DNA binding (GO:2000678)3.51318039
21limb bud formation (GO:0060174)3.43192312
22cell proliferation in forebrain (GO:0021846)3.42104319
23postsynaptic membrane organization (GO:0001941)3.41349312
24regulation of glutamate receptor signaling pathway (GO:1900449)3.37005603
25establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.36875683
26mitochondrion transport along microtubule (GO:0047497)3.36875683
27regulation of synapse maturation (GO:0090128)3.35550213
28presynaptic membrane assembly (GO:0097105)3.35347659
29positive regulation of synapse maturation (GO:0090129)3.33294688
30kidney morphogenesis (GO:0060993)3.30961598
31neurofilament cytoskeleton organization (GO:0060052)3.28476633
32regulation of growth hormone secretion (GO:0060123)3.27618581
33inner ear receptor stereocilium organization (GO:0060122)3.25747778
34daunorubicin metabolic process (GO:0044597)3.25341151
35polyketide metabolic process (GO:0030638)3.25341151
36doxorubicin metabolic process (GO:0044598)3.25341151
37cardiac ventricle formation (GO:0003211)3.23127041
38neuronal stem cell maintenance (GO:0097150)3.22438564
39righting reflex (GO:0060013)3.21183994
40viral transcription (GO:0019083)3.20262169
41regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.19837042
42negative regulation of axon guidance (GO:1902668)3.19571159
43transmission of nerve impulse (GO:0019226)3.17575101
44protein neddylation (GO:0045116)3.16670370
45positive regulation of neurotransmitter secretion (GO:0001956)3.14769056
46translational termination (GO:0006415)3.13348002
47regulation of short-term neuronal synaptic plasticity (GO:0048172)3.11453898
48auditory receptor cell stereocilium organization (GO:0060088)3.09684923
49spinal cord development (GO:0021510)3.08553836
50presynaptic membrane organization (GO:0097090)3.07643162
51lateral sprouting from an epithelium (GO:0060601)3.07187722
52ATP synthesis coupled proton transport (GO:0015986)3.06396718
53energy coupled proton transport, down electrochemical gradient (GO:0015985)3.06396718
54positive regulation of gastrulation (GO:2000543)3.06065433
55synapse assembly (GO:0007416)3.05969879
56left/right axis specification (GO:0070986)3.05741077
57regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.05320745
58protein localization to synapse (GO:0035418)3.04230171
59epithelial cilium movement (GO:0003351)3.02202705
60establishment of protein localization to mitochondrial membrane (GO:0090151)3.01822831
61neuronal ion channel clustering (GO:0045161)3.01114190
62positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.00658945
63epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.96335109
64cardiac chamber formation (GO:0003207)2.94432819
65adult walking behavior (GO:0007628)2.92449148
66neurotransmitter-gated ion channel clustering (GO:0072578)2.91709820
67negative regulation of appetite (GO:0032099)2.88929958
68negative regulation of response to food (GO:0032096)2.88929958
69response to pheromone (GO:0019236)2.85447250
70regulation of microtubule-based movement (GO:0060632)2.85122429
71response to auditory stimulus (GO:0010996)2.84234683
72mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.83651634
73regulation of MHC class I biosynthetic process (GO:0045343)2.82937758
74positive regulation of synapse assembly (GO:0051965)2.82693776
75regulation of feeding behavior (GO:0060259)2.81990546
76motile cilium assembly (GO:0044458)2.81811112
77synaptic transmission, cholinergic (GO:0007271)2.81412528
78olfactory bulb development (GO:0021772)2.80689409
79auditory behavior (GO:0031223)2.78299002
80regulation of cilium movement (GO:0003352)2.77317524
81axonemal dynein complex assembly (GO:0070286)2.77002665
82regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.75013792
83synaptic vesicle exocytosis (GO:0016079)2.75013372
84protein localization to cilium (GO:0061512)2.74937015
85head development (GO:0060322)2.74737034
86regulation of respiratory system process (GO:0044065)2.74525604
87pyrimidine nucleobase catabolic process (GO:0006208)2.74503697
88mitochondrial respiratory chain complex I assembly (GO:0032981)2.74410559
89NADH dehydrogenase complex assembly (GO:0010257)2.74410559
90mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.74410559
91central nervous system projection neuron axonogenesis (GO:0021952)2.73951106
92calcium ion-dependent exocytosis (GO:0017156)2.73818671
93cerebral cortex neuron differentiation (GO:0021895)2.73261744
94positive regulation of neuroblast proliferation (GO:0002052)2.73116487
95glutamate secretion (GO:0014047)2.73036301
96axonal fasciculation (GO:0007413)2.72916535
97dendritic spine morphogenesis (GO:0060997)2.72097205
98epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.71985124
99left/right pattern formation (GO:0060972)2.71825656
100neuron fate determination (GO:0048664)2.71151679
101negative regulation of axon extension (GO:0030517)2.70685631
102mechanosensory behavior (GO:0007638)2.69977491
103negative regulation of oligodendrocyte differentiation (GO:0048715)2.69747234
104axoneme assembly (GO:0035082)2.69621250
105neuron projection extension (GO:1990138)2.69339855
106cilium morphogenesis (GO:0060271)2.69319721
107microtubule bundle formation (GO:0001578)2.69165844
108negative regulation of synaptic transmission, GABAergic (GO:0032229)2.68752891
109cornea development in camera-type eye (GO:0061303)2.68698623
110regulation of synaptic vesicle exocytosis (GO:2000300)2.67259362
111forebrain neuron differentiation (GO:0021879)2.66544167
112sperm motility (GO:0030317)2.66277309
113neuron recognition (GO:0008038)2.66277112
114brain morphogenesis (GO:0048854)2.65986521
115spinal cord association neuron differentiation (GO:0021527)2.65853016
116protein complex biogenesis (GO:0070271)2.65602261
117ribosomal small subunit assembly (GO:0000028)2.65563024
118cilium movement (GO:0003341)2.65231838
119genetic imprinting (GO:0071514)2.64956329
120cilium assembly (GO:0042384)2.63812257
121cotranslational protein targeting to membrane (GO:0006613)2.63774357
122cell migration in hindbrain (GO:0021535)2.63710557
123regulation of collateral sprouting (GO:0048670)2.63485323
124dopaminergic neuron differentiation (GO:0071542)2.63217278
125opioid receptor signaling pathway (GO:0038003)2.62972052
126neural tube formation (GO:0001841)2.62525762
127dendrite development (GO:0016358)2.61643013
128synaptic transmission, glutamatergic (GO:0035249)2.61392556
129neuromuscular synaptic transmission (GO:0007274)2.60800983
130positive regulation of synaptic transmission, GABAergic (GO:0032230)2.60178470
131cilium organization (GO:0044782)2.59696669
132glial cell proliferation (GO:0014009)2.59459848
133calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.59206537
134positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.58810540
135SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.58658469
136positive regulation of mitochondrial fission (GO:0090141)2.56858092
137regulation of dopamine secretion (GO:0014059)2.56750683
138positive regulation of neurotransmitter transport (GO:0051590)2.56524517
139cerebral cortex radially oriented cell migration (GO:0021799)2.56182621
140female gonad development (GO:0008585)2.55433653
141positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.55339664
142protein targeting to ER (GO:0045047)2.54693966
143cilium or flagellum-dependent cell motility (GO:0001539)2.53302567
144ionotropic glutamate receptor signaling pathway (GO:0035235)2.53139932
145regulation of synapse assembly (GO:0051963)2.51741959
146G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.48601325
147neuron-neuron synaptic transmission (GO:0007270)2.48001969
148microtubule polymerization or depolymerization (GO:0031109)2.47841494
149regulation of respiratory gaseous exchange (GO:0043576)2.47476316
150cochlea development (GO:0090102)2.47219057
151negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.46072760
152synaptic vesicle endocytosis (GO:0048488)2.44972843
153ganglion development (GO:0061548)2.43689409
154embryonic camera-type eye development (GO:0031076)2.42900881
155somite development (GO:0061053)2.42262442
156regulation of development, heterochronic (GO:0040034)2.41423264
157regulation of timing of cell differentiation (GO:0048505)2.40808736
158behavioral response to nicotine (GO:0035095)2.40352335
159glutamate receptor signaling pathway (GO:0007215)2.39499446
160neuron projection extension involved in neuron projection guidance (GO:1902284)2.38698648
161axon extension involved in axon guidance (GO:0048846)2.38698648
162axon extension (GO:0048675)2.38264847
163negative regulation of glial cell proliferation (GO:0060253)2.37800788
164negative regulation of epidermis development (GO:0045683)2.37105560
165behavioral response to ethanol (GO:0048149)2.36098859
166peptidyl-arginine N-methylation (GO:0035246)2.35788135
167peptidyl-arginine methylation (GO:0018216)2.35788135
168positive regulation of dendritic spine morphogenesis (GO:0061003)2.35658960
169negative regulation of astrocyte differentiation (GO:0048712)2.35296740

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.35969573
2GBX2_23144817_ChIP-Seq_PC3_Human3.57927594
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.17973281
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.04605287
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.04511758
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.59602882
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.33475144
8CBX2_27304074_Chip-Seq_ESCs_Mouse2.26699831
9* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.26400411
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.24571946
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.21923052
12* REST_21632747_ChIP-Seq_MESCs_Mouse2.20435737
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.14476533
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13606706
15VDR_22108803_ChIP-Seq_LS180_Human2.04698952
16* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.04623660
17ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99196344
18TAF15_26573619_Chip-Seq_HEK293_Human1.99091014
19RNF2_27304074_Chip-Seq_NSC_Mouse1.97197284
20RNF2_18974828_ChIP-Seq_MESCs_Mouse1.92937731
21EZH2_18974828_ChIP-Seq_MESCs_Mouse1.92937731
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89705595
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.82147937
24RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.80625963
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.79729522
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78068300
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77129695
28FUS_26573619_Chip-Seq_HEK293_Human1.76248221
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.74010763
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.72542866
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.71372964
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.70265262
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.70066322
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.68690514
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.68584921
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.63502568
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63272617
38POU5F1_16153702_ChIP-ChIP_HESCs_Human1.61450379
39RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.60037538
40* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.57405726
41TP63_19390658_ChIP-ChIP_HaCaT_Human1.55668115
42SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.54153827
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54065996
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49283226
45DROSHA_22980978_ChIP-Seq_HELA_Human1.48399403
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47133390
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.47133390
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46422345
49IRF1_19129219_ChIP-ChIP_H3396_Human1.45102000
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44805316
51P300_19829295_ChIP-Seq_ESCs_Human1.44535333
52* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.43940180
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40863874
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39707941
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.38436678
56* NANOG_18555785_Chip-Seq_ESCs_Mouse1.36588004
57SMAD4_21799915_ChIP-Seq_A2780_Human1.36445406
58CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34797938
59* REST_18959480_ChIP-ChIP_MESCs_Mouse1.34601348
60* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.34031915
61ETV2_25802403_ChIP-Seq_MESCs_Mouse1.32926854
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.30235728
63* P53_22387025_ChIP-Seq_ESCs_Mouse1.27185437
64* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26557341
65* E2F1_18555785_Chip-Seq_ESCs_Mouse1.26108901
66IGF1R_20145208_ChIP-Seq_DFB_Human1.25868852
67MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.25298229
68* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.25139845
69GATA1_26923725_Chip-Seq_HPCs_Mouse1.24986793
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23990125
71KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.22139465
72CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.20841870
73NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.19526463
74* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18697747
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17926696
76* RING1B_27294783_Chip-Seq_ESCs_Mouse1.17435493
77SOX2_16153702_ChIP-ChIP_HESCs_Human1.17286115
78* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.16601797
79POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16290762
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16075776
81RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15307440
82* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.14969186
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14646486
84STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14224460
85* CMYC_18555785_Chip-Seq_ESCs_Mouse1.13301239
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12827852
87TP53_20018659_ChIP-ChIP_R1E_Mouse1.11965122
88EWS_26573619_Chip-Seq_HEK293_Human1.11317382
89FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.11108352
90SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10385324
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10152741
92* RING1B_27294783_Chip-Seq_NPCs_Mouse1.10127268
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09440490
94* ELK4_26923725_Chip-Seq_MESODERM_Mouse1.09256787
95SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.08989285
96CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08661275
97MYC_18940864_ChIP-ChIP_HL60_Human1.08450681
98* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08268997
99* P300_18555785_Chip-Seq_ESCs_Mouse1.08119748
100RBPJ_22232070_ChIP-Seq_NCS_Mouse1.07922117
101* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.07743218
102EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06873197
103CBP_20019798_ChIP-Seq_JUKART_Human1.06213290
104IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06213290
105MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05244711
106GABP_17652178_ChIP-ChIP_JURKAT_Human1.04441389
107* STAT3_18555785_Chip-Seq_ESCs_Mouse1.03622773
108TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03590859
109YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02934924
110MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02680310
111* NMYC_18555785_Chip-Seq_ESCs_Mouse1.02441792
112IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02340980
113TCF4_23295773_ChIP-Seq_U87_Human1.02264415
114* OCT4_18555785_Chip-Seq_ESCs_Mouse1.01502969
115PIAS1_25552417_ChIP-Seq_VCAP_Human1.01222674
116TP53_22573176_ChIP-Seq_HFKS_Human1.01002886
117RUNX2_22187159_ChIP-Seq_PCA_Human1.00859782
118* SOX9_26525672_Chip-Seq_HEART_Mouse1.00152803
119CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00102893
120RARB_27405468_Chip-Seq_BRAIN_Mouse0.99839680
121AR_25329375_ChIP-Seq_VCAP_Human0.99736623
122ZNF274_21170338_ChIP-Seq_K562_Hela0.99597248
123AR_21572438_ChIP-Seq_LNCaP_Human0.98543821
124CTCF_27219007_Chip-Seq_Bcells_Human0.97572100
125ERG_21242973_ChIP-ChIP_JURKAT_Human0.96432632
126CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95704313
127P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94257308
128KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93786897
129* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93683690
130SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93553481
131SMAD3_21741376_ChIP-Seq_ESCs_Human0.90352361
132STAT3_23295773_ChIP-Seq_U87_Human0.88870391
133STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.88520504
134TAL1_26923725_Chip-Seq_HPCs_Mouse0.87965796

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.82751409
2MP0000566_synostosis3.79137129
3MP0005423_abnormal_somatic_nervous3.46813887
4MP0003123_paternal_imprinting3.02860715
5MP0006292_abnormal_olfactory_placode2.97168707
6MP0003787_abnormal_imprinting2.36764409
7MP0004133_heterotaxia2.33136188
8MP0006276_abnormal_autonomic_nervous2.31066794
9MP0002822_catalepsy2.27849677
10MP0009379_abnormal_foot_pigmentation2.25103662
11MP0004859_abnormal_synaptic_plasticity2.22016328
12MP0002102_abnormal_ear_morphology2.17302283
13MP0005645_abnormal_hypothalamus_physiol2.09943722
14MP0002653_abnormal_ependyma_morphology2.08325067
15MP0000778_abnormal_nervous_system2.07279000
16MP0005499_abnormal_olfactory_system2.01670034
17MP0005394_taste/olfaction_phenotype2.01670034
18MP0003890_abnormal_embryonic-extraembry2.00940326
19MP0001529_abnormal_vocalization2.00697826
20MP0003879_abnormal_hair_cell1.97523904
21MP0008789_abnormal_olfactory_epithelium1.96034724
22MP0001486_abnormal_startle_reflex1.93593591
23MP0005410_abnormal_fertilization1.92053301
24MP0010030_abnormal_orbit_morphology1.91263747
25MP0009046_muscle_twitch1.87218254
26MP0001968_abnormal_touch/_nociception1.84843745
27MP0002751_abnormal_autonomic_nervous1.83391576
28MP0005646_abnormal_pituitary_gland1.81988115
29MP0003635_abnormal_synaptic_transmissio1.72753959
30MP0009780_abnormal_chondrocyte_physiolo1.72583242
31MP0002184_abnormal_innervation1.71147427
32MP0001984_abnormal_olfaction1.67109715
33MP0002063_abnormal_learning/memory/cond1.66817884
34MP0002736_abnormal_nociception_after1.61944159
35MP0002735_abnormal_chemical_nociception1.60667291
36MP0000026_abnormal_inner_ear1.60141980
37MP0002572_abnormal_emotion/affect_behav1.58972849
38MP0009745_abnormal_behavioral_response1.57482928
39MP0003878_abnormal_ear_physiology1.57389193
40MP0005377_hearing/vestibular/ear_phenot1.57389193
41MP0004742_abnormal_vestibular_system1.57174650
42MP0001188_hyperpigmentation1.57173208
43MP0002277_abnormal_respiratory_mucosa1.52994035
44MP0002557_abnormal_social/conspecific_i1.51510003
45MP0003938_abnormal_ear_development1.50081466
46MP0000049_abnormal_middle_ear1.44889037
47MP0003941_abnormal_skin_development1.42486570
48MP0002067_abnormal_sensory_capabilities1.41385994
49MP0000631_abnormal_neuroendocrine_gland1.40616305
50MP0001485_abnormal_pinna_reflex1.39193833
51MP0002064_seizures1.37051141
52MP0004270_analgesia1.35664810
53MP0002734_abnormal_mechanical_nocicepti1.33196675
54MP0003121_genomic_imprinting1.32439646
55MP0002928_abnormal_bile_duct1.31265886
56MP0010386_abnormal_urinary_bladder1.27199471
57MP0000537_abnormal_urethra_morphology1.26939334
58MP0005253_abnormal_eye_physiology1.25404438
59MP0003861_abnormal_nervous_system1.24968227
60MP0002272_abnormal_nervous_system1.23109404
61MP0003119_abnormal_digestive_system1.22995038
62MP0001440_abnormal_grooming_behavior1.22834513
63MP0003698_abnormal_male_reproductive1.20786005
64MP0001963_abnormal_hearing_physiology1.19767595
65MP0003122_maternal_imprinting1.19408972
66MP0003011_delayed_dark_adaptation1.18081582
67MP0001905_abnormal_dopamine_level1.17567085
68MP0005195_abnormal_posterior_eye1.17467507
69MP0000955_abnormal_spinal_cord1.13480760
70MP0002234_abnormal_pharynx_morphology1.13108929
71MP0003283_abnormal_digestive_organ1.11807235
72MP0001293_anophthalmia1.11362278
73MP0005386_behavior/neurological_phenoty1.10887283
74MP0004924_abnormal_behavior1.10887283
75MP0002233_abnormal_nose_morphology1.09573269
76MP0008004_abnormal_stomach_pH1.09563666
77MP0002882_abnormal_neuron_morphology1.08267146
78MP0002152_abnormal_brain_morphology1.07776662
79MP0002249_abnormal_larynx_morphology1.06319848
80MP0008877_abnormal_DNA_methylation1.04906315
81MP0002752_abnormal_somatic_nervous1.04406473
82MP0009053_abnormal_anal_canal1.03005066
83MP0003755_abnormal_palate_morphology1.01919299
84MP0008058_abnormal_DNA_repair1.01340489
85MP0003646_muscle_fatigue1.00174653
86MP0004811_abnormal_neuron_physiology0.99621632
87MP0003136_yellow_coat_color0.96515196
88MP0002163_abnormal_gland_morphology0.96445208
89MP0003937_abnormal_limbs/digits/tail_de0.95074174
90MP0002282_abnormal_trachea_morphology0.95030351
91MP0005391_vision/eye_phenotype0.94049807
92MP0004885_abnormal_endolymph0.93302665
93MP0001286_abnormal_eye_development0.92832378
94MP0002938_white_spotting0.90302383
95MP0004145_abnormal_muscle_electrophysio0.87335106
96MP0002210_abnormal_sex_determination0.87007830
97MP0005084_abnormal_gallbladder_morpholo0.86945731
98MP0005248_abnormal_Harderian_gland0.86609579
99MP0001986_abnormal_taste_sensitivity0.85072583
100MP0001929_abnormal_gametogenesis0.84709411
101MP0002116_abnormal_craniofacial_bone0.82082109
102MP0002638_abnormal_pupillary_reflex0.81625733
103MP0008995_early_reproductive_senescence0.81173149
104MP0004142_abnormal_muscle_tone0.81144361
105MP0008961_abnormal_basal_metabolism0.80946072
106MP0006072_abnormal_retinal_apoptosis0.79326437
107MP0002697_abnormal_eye_size0.78730188
108MP0001502_abnormal_circadian_rhythm0.78207171
109MP0002909_abnormal_adrenal_gland0.77895555
110MP0003111_abnormal_nucleus_morphology0.77297215
111MP0003942_abnormal_urinary_system0.76456989
112MP0002733_abnormal_thermal_nociception0.76288198
113MP0002160_abnormal_reproductive_system0.76229984
114MP0002066_abnormal_motor_capabilities/c0.75219265
115MP0002081_perinatal_lethality0.74886771
116MP0000534_abnormal_ureter_morphology0.73225931
117MP0005551_abnormal_eye_electrophysiolog0.73118737
118MP0001970_abnormal_pain_threshold0.72594760
119MP0000427_abnormal_hair_cycle0.71111304
120MP0000647_abnormal_sebaceous_gland0.68752768
121MP0001299_abnormal_eye_distance/0.67684418

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)4.15491114
2Dynein arm defect of respiratory motile cilia (HP:0012255)4.15491114
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.66295368
4Congenital primary aphakia (HP:0007707)3.48541203
5Abnormality of the labia minora (HP:0012880)3.41598825
6Nephrogenic diabetes insipidus (HP:0009806)3.34353870
7Myokymia (HP:0002411)3.28056356
8Febrile seizures (HP:0002373)3.27841701
9Pancreatic cysts (HP:0001737)3.23841888
10Vaginal atresia (HP:0000148)3.18403105
11Agitation (HP:0000713)3.18240690
12Hepatoblastoma (HP:0002884)3.14592780
13Septo-optic dysplasia (HP:0100842)3.13839510
14Focal motor seizures (HP:0011153)3.07994324
15Genital tract atresia (HP:0001827)3.06865550
16Chromsome breakage (HP:0040012)3.01767384
17Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.96163517
18Epileptic encephalopathy (HP:0200134)2.86854374
19Intestinal atresia (HP:0011100)2.84859268
20Abnormal respiratory epithelium morphology (HP:0012253)2.81367982
21Abnormal respiratory motile cilium morphology (HP:0005938)2.81367982
22Chronic hepatic failure (HP:0100626)2.75978092
23Polyphagia (HP:0002591)2.71089739
24Hyperventilation (HP:0002883)2.70642936
25Abnormal ciliary motility (HP:0012262)2.69909993
26Poor coordination (HP:0002370)2.68935284
27Adrenal hypoplasia (HP:0000835)2.68782043
28Abnormality of the renal medulla (HP:0100957)2.67183006
29Abnormal respiratory motile cilium physiology (HP:0012261)2.63254887
30Sclerocornea (HP:0000647)2.55466661
31Cystic liver disease (HP:0006706)2.51579175
32Absent rod-and cone-mediated responses on ERG (HP:0007688)2.40721379
33Reticulocytopenia (HP:0001896)2.38725632
34Lissencephaly (HP:0001339)2.38680958
35Abnormal hair whorl (HP:0010721)2.36024528
36Tubular atrophy (HP:0000092)2.35540879
37Preaxial hand polydactyly (HP:0001177)2.35000740
38Abnormality of cells of the erythroid lineage (HP:0012130)2.34879776
39Anophthalmia (HP:0000528)2.29773424
40Esophageal atresia (HP:0002032)2.29307283
41Anencephaly (HP:0002323)2.28991521
42Diastasis recti (HP:0001540)2.28201008
43Growth hormone deficiency (HP:0000824)2.27810299
44Abnormal pancreas size (HP:0012094)2.27059872
45Pachygyria (HP:0001302)2.26586722
46Absent eyebrow (HP:0002223)2.26291911
47Gastrointestinal atresia (HP:0002589)2.25978779
48Hyperglycinemia (HP:0002154)2.25528647
49Occipital encephalocele (HP:0002085)2.21059303
50Narrow forehead (HP:0000341)2.20743977
51Abnormal rod and cone electroretinograms (HP:0008323)2.20726321
52Pendular nystagmus (HP:0012043)2.20042293
53Supernumerary spleens (HP:0009799)2.16450155
54Aplasia/Hypoplasia of the uvula (HP:0010293)2.15634017
55Progressive cerebellar ataxia (HP:0002073)2.14523650
56Broad-based gait (HP:0002136)2.14311257
57Concave nail (HP:0001598)2.13966523
58High anterior hairline (HP:0009890)2.13725942
59Optic nerve hypoplasia (HP:0000609)2.13098402
60Acute necrotizing encephalopathy (HP:0006965)2.12291680
61Aplasia/Hypoplasia of the brainstem (HP:0007362)2.12021054
62Hypoplasia of the brainstem (HP:0002365)2.12021054
63Duplication of thumb phalanx (HP:0009942)2.09412250
64Abdominal situs inversus (HP:0003363)2.07860523
65Abnormality of abdominal situs (HP:0011620)2.07860523
66Nephroblastoma (Wilms tumor) (HP:0002667)2.05347645
67Absent radius (HP:0003974)2.05006527
68Absent forearm bone (HP:0003953)2.04650025
69Aplasia involving forearm bones (HP:0009822)2.04650025
70Aplasia/Hypoplasia of the tongue (HP:0010295)2.03191210
71Stenosis of the external auditory canal (HP:0000402)2.02573944
72Abnormality of the antihelix (HP:0009738)2.02467451
73Postaxial foot polydactyly (HP:0001830)2.00486191
74Embryonal renal neoplasm (HP:0011794)1.99850849
75Type II lissencephaly (HP:0007260)1.99571641
76Micropenis (HP:0000054)1.99293617
77Acute encephalopathy (HP:0006846)1.98948431
78Retinal dysplasia (HP:0007973)1.97062958
79Aplasia involving bones of the extremities (HP:0009825)1.96624635
80Aplasia involving bones of the upper limbs (HP:0009823)1.96624635
81Aplasia of the phalanges of the hand (HP:0009802)1.96624635
82Recurrent corneal erosions (HP:0000495)1.95313452
83Nephronophthisis (HP:0000090)1.94686102
84Alacrima (HP:0000522)1.94565451
85Thyroid-stimulating hormone excess (HP:0002925)1.94524111
86Protruding tongue (HP:0010808)1.94235988
87Abnormality of the right ventricle (HP:0001707)1.94061713
88Prostate neoplasm (HP:0100787)1.93363295
89Focal seizures (HP:0007359)1.92755746
90Congenital stationary night blindness (HP:0007642)1.91947498
91Lipid accumulation in hepatocytes (HP:0006561)1.91873138
92Congenital hepatic fibrosis (HP:0002612)1.91811756
93Congenital malformation of the right heart (HP:0011723)1.91168567
94Double outlet right ventricle (HP:0001719)1.91168567
95Decreased lacrimation (HP:0000633)1.91022144
96Atonic seizures (HP:0010819)1.88669757
97Labial hypoplasia (HP:0000066)1.87999590
98Bifid tongue (HP:0010297)1.87331635
99Bile duct proliferation (HP:0001408)1.87116368
100Abnormal biliary tract physiology (HP:0012439)1.87116368
101Cutaneous finger syndactyly (HP:0010554)1.86409822
102Abnormal number of erythroid precursors (HP:0012131)1.86117960
103Increased hepatocellular lipid droplets (HP:0006565)1.86034479
104Male pseudohermaphroditism (HP:0000037)1.85848488
105Ectopic kidney (HP:0000086)1.84696811
106Absent speech (HP:0001344)1.84249577
107Abnormality of incisor morphology (HP:0011063)1.83145175
108Aplasia/Hypoplasia of the spleen (HP:0010451)1.82623317
109Decreased testicular size (HP:0008734)1.81720464
110Multicystic kidney dysplasia (HP:0000003)1.81610910
111Absent septum pellucidum (HP:0001331)1.81233350
112Scrotal hypoplasia (HP:0000046)1.81042691
113Sleep apnea (HP:0010535)1.80518886
114Medial flaring of the eyebrow (HP:0010747)1.80187886
115Aplasia/Hypoplasia of the lens (HP:0008063)1.79899612
116True hermaphroditism (HP:0010459)1.79775428
117Broad foot (HP:0001769)1.79650910
118Abnormality of midbrain morphology (HP:0002418)1.79616622
119Molar tooth sign on MRI (HP:0002419)1.79616622
120Oligodactyly (HP:0012165)1.79569703
121Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79441738
122Abnormal mitochondria in muscle tissue (HP:0008316)1.78881628
123Abnormality of the nasal septum (HP:0000419)1.78687570
124Retinitis pigmentosa (HP:0000510)1.78454264
125Gastroesophageal reflux (HP:0002020)1.78349707
1263-Methylglutaconic aciduria (HP:0003535)1.78326400
127Left ventricular hypertrophy (HP:0001712)1.77571312
128Hypoplastic female external genitalia (HP:0012815)1.77475886
129Meckel diverticulum (HP:0002245)1.77285189
130Abnormality of the corticospinal tract (HP:0002492)1.77223244
131Decreased central vision (HP:0007663)1.76466765
132Morphological abnormality of the middle ear (HP:0008609)1.76375484
133Abnormality of the preputium (HP:0100587)1.76240673
134Bony spicule pigmentary retinopathy (HP:0007737)1.76149462
135Abnormality of the ileum (HP:0001549)1.75702027
136Failure to thrive in infancy (HP:0001531)1.75665583
137Optic disc pallor (HP:0000543)1.75418814
138Fibular aplasia (HP:0002990)1.75038725
139Dyschromatopsia (HP:0007641)1.74132219
140Cutaneous syndactyly (HP:0012725)1.73900264
141Heterotopia (HP:0002282)1.72601074
142Rib fusion (HP:0000902)1.72573093
143Fetal akinesia sequence (HP:0001989)1.72557650
144Duplicated collecting system (HP:0000081)1.72505917
145Small intestinal stenosis (HP:0012848)1.71688352
146Duodenal stenosis (HP:0100867)1.71688352
147Maternal diabetes (HP:0009800)1.71525106
148Choroideremia (HP:0001139)1.70734437
149Abnormality of the septum pellucidum (HP:0007375)1.70454793
150Triphalangeal thumb (HP:0001199)1.70189065
151Gait imbalance (HP:0002141)1.67820697
152Pancreatic fibrosis (HP:0100732)1.67271938
153Rhinitis (HP:0012384)1.66895203
154Unilateral renal agenesis (HP:0000122)1.66087933
155Trigonocephaly (HP:0000243)1.65240929
156Abnormality of the incisor (HP:0000676)1.65203726
157Anomalous pulmonary venous return (HP:0010772)1.64858900
158Oligodactyly (hands) (HP:0001180)1.63443621
159Tubulointerstitial nephritis (HP:0001970)1.62821924
160Limb dystonia (HP:0002451)1.61915517
161Specific learning disability (HP:0001328)1.61780183
162Aplasia/Hypoplasia of the sternum (HP:0006714)1.61742903
163Excessive salivation (HP:0003781)1.61246855
164Drooling (HP:0002307)1.61246855
165Postaxial hand polydactyly (HP:0001162)1.60578603
166Breast aplasia (HP:0100783)1.60138779

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.80487090
2SIK33.51444077
3EPHA23.27127732
4PINK12.85860919
5MARK12.67385922
6EPHA42.53446271
7WNK32.49729843
8MAPK132.49259698
9CDK122.31663037
10CCNB12.21662849
11MAP4K22.19951254
12NTRK32.19445120
13MAP2K72.11486114
14SIK21.92921261
15DAPK21.89340928
16EPHB21.85950573
17BMPR1B1.69355403
18WNK41.68588527
19TRIM281.66122960
20STK38L1.63537795
21SRPK11.60071450
22BRD41.55356474
23AKT31.51686708
24MAP3K41.49800316
25CSNK1G21.49474745
26PRKD31.49051462
27DYRK21.48665489
28PLK21.47185209
29BCKDK1.45856259
30MAP3K91.42401755
31DAPK11.40802906
32TLK11.39637963
33CDK31.38716238
34NTRK21.37732733
35YES11.36300497
36DYRK1B1.35308787
37PAK31.34645200
38SGK21.33509233
39ERBB31.25089863
40MKNK21.22459539
41CSNK1G31.21875649
42UHMK11.21533023
43TYRO31.19995309
44DYRK31.18172791
45ICK1.18035025
46KSR11.16995042
47ZAK1.16141593
48CDK191.15242828
49BCR1.10661649
50CDK81.10655326
51BUB11.09133785
52ADRBK21.07095345
53GRK11.06625275
54SGK4941.06453883
55SGK2231.06453883
56EPHA31.06089296
57CSNK1A1L1.05401954
58MAPK151.05293143
59STK380.99938777
60CSNK1G10.98963753
61PRPF4B0.97713686
62CHEK20.95917405
63LATS20.95391266
64DYRK1A0.95036318
65MINK10.94134664
66GRK70.92832389
67PKN10.88985443
68MAP3K120.86593417
69FGFR20.83818173
70PRKCG0.83420014
71CAMKK20.82512253
72FGFR10.80787550
73BRAF0.78845035
74MKNK10.78564618
75TSSK60.77598498
76CAMK10.76810266
77BRSK10.74091496
78PLK30.67778415
79NEK60.66707923
80MELK0.66192612
81TNIK0.66006497
82FRK0.65479735
83PRKACA0.63911961
84PRKCZ0.63720655
85CAMK40.63055945
86MAPKAPK30.62678753
87STK390.62039528
88PNCK0.61565992
89PRKCH0.61419181
90EIF2AK20.60679575
91CAMK1D0.60659585
92PHKG20.60514844
93PHKG10.60514844
94TTK0.60026126
95ERBB40.59775295
96LATS10.59694873
97ERBB20.59130179
98CDK180.58553148
99SGK30.58077385
100AURKA0.57793054
101FER0.57723185
102CDK70.57362395
103CDC42BPA0.56566053
104PAK60.56194243
105CAMKK10.55074948
106MAP3K110.54633875
107CHEK10.54019568
108CSNK1E0.52902114
109CDC70.52501814
110AKT20.52317019
111ATR0.49830218
112ADRBK10.49387638
113CDK150.49335693
114MARK30.49275817
115CDK50.48159402
116NUAK10.48157640
117SGK10.48052508
118RPS6KA20.47222210
119PLK10.47108818
120PRKCE0.46869897
121VRK10.46430345
122RPS6KA40.46258594
123EEF2K0.46107323
124CDK11A0.43483257
125CAMK2A0.43309188
126CSNK1A10.42879593
127MUSK0.42522543
128CAMK1G0.42007647
129PDK40.41713064
130PDK30.41713064
131INSRR0.41252120
132CDK140.40913540
133MARK20.40650022
134PRKCI0.39983024
135PLK40.39923655
136STK160.39682709
137PIK3CA0.39293115
138NEK20.38672666
139MAP2K40.38064882
140RPS6KA50.37784332
141TESK10.37712360
142CSNK1D0.37691087
143MAP3K60.37595794
144GSK3B0.37205123
145BRSK20.36055272
146OXSR10.35302028
147STK110.35158050

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.97545428
2Oxidative phosphorylation_Homo sapiens_hsa001903.49970610
3Parkinsons disease_Homo sapiens_hsa050123.11768685
4Synaptic vesicle cycle_Homo sapiens_hsa047213.04716850
5Ribosome_Homo sapiens_hsa030103.00597768
6Cardiac muscle contraction_Homo sapiens_hsa042602.61242614
7Basal cell carcinoma_Homo sapiens_hsa052172.49876333
8Hedgehog signaling pathway_Homo sapiens_hsa043402.39359899
9Olfactory transduction_Homo sapiens_hsa047402.31150271
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.26087058
11Taste transduction_Homo sapiens_hsa047422.24849001
12Huntingtons disease_Homo sapiens_hsa050162.24611824
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.17248581
14Steroid biosynthesis_Homo sapiens_hsa001002.13473991
15Alzheimers disease_Homo sapiens_hsa050102.11523628
16Axon guidance_Homo sapiens_hsa043602.09699085
17Protein export_Homo sapiens_hsa030602.09653155
18Morphine addiction_Homo sapiens_hsa050322.06863469
19Fanconi anemia pathway_Homo sapiens_hsa034601.99959010
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.93919043
21Circadian entrainment_Homo sapiens_hsa047131.93256009
22Linoleic acid metabolism_Homo sapiens_hsa005911.89036944
23GABAergic synapse_Homo sapiens_hsa047271.88206998
24Glutamatergic synapse_Homo sapiens_hsa047241.84994376
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.84252202
26Amphetamine addiction_Homo sapiens_hsa050311.81745931
27Collecting duct acid secretion_Homo sapiens_hsa049661.78637818
28Serotonergic synapse_Homo sapiens_hsa047261.77537512
29Notch signaling pathway_Homo sapiens_hsa043301.71050753
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.69749981
31Phototransduction_Homo sapiens_hsa047441.67489465
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.65316943
33mRNA surveillance pathway_Homo sapiens_hsa030151.63315632
34Dopaminergic synapse_Homo sapiens_hsa047281.60259784
35Wnt signaling pathway_Homo sapiens_hsa043101.58212108
36Insulin secretion_Homo sapiens_hsa049111.54003488
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.53784385
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53637199
39Hippo signaling pathway_Homo sapiens_hsa043901.52722466
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.41952981
41Cholinergic synapse_Homo sapiens_hsa047251.32488436
42Alcoholism_Homo sapiens_hsa050341.32020571
43Butanoate metabolism_Homo sapiens_hsa006501.31520286
44Calcium signaling pathway_Homo sapiens_hsa040201.29710573
45Long-term potentiation_Homo sapiens_hsa047201.28718580
46RNA polymerase_Homo sapiens_hsa030201.25068873
47Spliceosome_Homo sapiens_hsa030401.20891023
48Melanogenesis_Homo sapiens_hsa049161.18841376
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17654219
50Cell cycle_Homo sapiens_hsa041101.14774477
51Propanoate metabolism_Homo sapiens_hsa006401.11819917
52Salivary secretion_Homo sapiens_hsa049701.11504101
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.10944704
54Renin secretion_Homo sapiens_hsa049241.10863371
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10215648
56Cocaine addiction_Homo sapiens_hsa050301.09102199
57Basal transcription factors_Homo sapiens_hsa030221.03338586
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03079174
59Melanoma_Homo sapiens_hsa052181.02376448
60Systemic lupus erythematosus_Homo sapiens_hsa053221.01414818
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99118491
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.98721550
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95697683
64Oocyte meiosis_Homo sapiens_hsa041140.95639123
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95228904
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.92419442
67Oxytocin signaling pathway_Homo sapiens_hsa049210.91702615
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91248128
69Long-term depression_Homo sapiens_hsa047300.90448287
70Vibrio cholerae infection_Homo sapiens_hsa051100.89309757
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88544216
72Peroxisome_Homo sapiens_hsa041460.85996787
73Mismatch repair_Homo sapiens_hsa034300.82243656
74ErbB signaling pathway_Homo sapiens_hsa040120.81887673
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81384084
76Autoimmune thyroid disease_Homo sapiens_hsa053200.81380702
77cAMP signaling pathway_Homo sapiens_hsa040240.80286792
78Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.79911117
79MAPK signaling pathway_Homo sapiens_hsa040100.78296387
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76692519
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75977593
82Nitrogen metabolism_Homo sapiens_hsa009100.75877427
83RNA transport_Homo sapiens_hsa030130.74585008
84Ras signaling pathway_Homo sapiens_hsa040140.74120838
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73357144
86Gastric acid secretion_Homo sapiens_hsa049710.71492346
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71220247
88Colorectal cancer_Homo sapiens_hsa052100.70405988
89Gap junction_Homo sapiens_hsa045400.69745361
90Circadian rhythm_Homo sapiens_hsa047100.66620366
91Rap1 signaling pathway_Homo sapiens_hsa040150.65416086
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65277775
93TGF-beta signaling pathway_Homo sapiens_hsa043500.64845274
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64784723
95Tight junction_Homo sapiens_hsa045300.64525230
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64150521
97Type II diabetes mellitus_Homo sapiens_hsa049300.63999992
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61746649
99Adherens junction_Homo sapiens_hsa045200.61439541
100Metabolic pathways_Homo sapiens_hsa011000.60000899
101Homologous recombination_Homo sapiens_hsa034400.59995771
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59146176
103Sulfur relay system_Homo sapiens_hsa041220.58998246
104Fat digestion and absorption_Homo sapiens_hsa049750.57796862
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57496353
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57226213
107Glycerolipid metabolism_Homo sapiens_hsa005610.56561841
108Arachidonic acid metabolism_Homo sapiens_hsa005900.54273320
109Tryptophan metabolism_Homo sapiens_hsa003800.53928518
110Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53647152
111MicroRNAs in cancer_Homo sapiens_hsa052060.52769792
112Glucagon signaling pathway_Homo sapiens_hsa049220.52244799
113Pathways in cancer_Homo sapiens_hsa052000.51489794
114Retinol metabolism_Homo sapiens_hsa008300.50664143
115Ovarian steroidogenesis_Homo sapiens_hsa049130.50068269
116Arginine and proline metabolism_Homo sapiens_hsa003300.49963588
117Regulation of autophagy_Homo sapiens_hsa041400.49060699
118Steroid hormone biosynthesis_Homo sapiens_hsa001400.47933251
119Base excision repair_Homo sapiens_hsa034100.47831362
120Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46009580
121Fatty acid biosynthesis_Homo sapiens_hsa000610.45739228
122Lysine degradation_Homo sapiens_hsa003100.44764743
123Endometrial cancer_Homo sapiens_hsa052130.44657376
124cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44487820
125Estrogen signaling pathway_Homo sapiens_hsa049150.44461230
126Chemical carcinogenesis_Homo sapiens_hsa052040.43829132
127GnRH signaling pathway_Homo sapiens_hsa049120.42636128
128Ether lipid metabolism_Homo sapiens_hsa005650.42251746
129Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41270685
130Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40629406
131RNA degradation_Homo sapiens_hsa030180.40539440
132Rheumatoid arthritis_Homo sapiens_hsa053230.40494034
133Non-homologous end-joining_Homo sapiens_hsa034500.40088606
134HTLV-I infection_Homo sapiens_hsa051660.39931284
135Dilated cardiomyopathy_Homo sapiens_hsa054140.39448210
136Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39143741
137Primary bile acid biosynthesis_Homo sapiens_hsa001200.37192197
138Cysteine and methionine metabolism_Homo sapiens_hsa002700.36557373
139Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36239648
140Maturity onset diabetes of the young_Homo sapiens_hsa049500.36018667
141Glioma_Homo sapiens_hsa052140.34108154
142Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.33533304
143Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33114882
144Vascular smooth muscle contraction_Homo sapiens_hsa042700.32658811
145Fatty acid metabolism_Homo sapiens_hsa012120.32611784
146Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32426125
147Pyruvate metabolism_Homo sapiens_hsa006200.30944599
148Purine metabolism_Homo sapiens_hsa002300.30040835
149Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29967495
150Caffeine metabolism_Homo sapiens_hsa002320.29654298
151Selenocompound metabolism_Homo sapiens_hsa004500.28954315

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