LEMD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a LEM domain-containing transmembrane protein of the inner nuclear membrane. The protein is involved in nuclear structure organization and plays a role in cell signaling and differentiation. Mutations in this gene result in Cataract 46, juvenile-onset. Multiple transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of histone deacetylation (GO:0031065)4.15738691
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.08502656
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.08502656
4negative regulation of erythrocyte differentiation (GO:0045647)3.79101731
5maternal placenta development (GO:0001893)3.77542685
6antigen processing and presentation of endogenous antigen (GO:0019883)3.63424917
7apoptotic cell clearance (GO:0043277)3.47250109
8protein localization to endosome (GO:0036010)3.38902972
9response to laminar fluid shear stress (GO:0034616)3.38690575
10response to muramyl dipeptide (GO:0032495)3.38078701
11positive regulation by symbiont of host defense response (GO:0052509)3.25921043
12modulation by symbiont of host defense response (GO:0052031)3.25921043
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.25921043
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.25921043
15positive regulation by organism of defense response of other organism involved in symbiotic interact3.25921043
16modulation by symbiont of host immune response (GO:0052553)3.25921043
17low-density lipoprotein particle clearance (GO:0034383)3.24315161
18negative regulation of fatty acid transport (GO:2000192)3.21557950
19response to peptidoglycan (GO:0032494)3.20445511
20skin morphogenesis (GO:0043589)3.18520671
21negative regulation of cell size (GO:0045792)3.15009285
22endothelial cell chemotaxis (GO:0035767)3.14361582
23regulation of gamma-delta T cell differentiation (GO:0045586)3.10108422
24mannose metabolic process (GO:0006013)3.05639418
25NIK/NF-kappaB signaling (GO:0038061)3.05622959
26positive regulation of p38MAPK cascade (GO:1900745)3.03453187
27regulation of cholesterol storage (GO:0010885)3.01376422
28regulation of fatty acid beta-oxidation (GO:0031998)3.00816528
29positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.00201269
30modulation by symbiont of host cellular process (GO:0044068)2.98930077
31regulation of cholesterol homeostasis (GO:2000188)2.95496670
32regulation of p38MAPK cascade (GO:1900744)2.95340257
33positive regulation of protein deacetylation (GO:0090312)2.95165979
34cell-substrate junction assembly (GO:0007044)2.92509315
35regulation of extracellular matrix disassembly (GO:0010715)2.91215893
36positive regulation of Cdc42 GTPase activity (GO:0043089)2.91160089
37antigen processing and presentation via MHC class Ib (GO:0002475)2.88703983
38positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.86568192
393-UTR-mediated mRNA stabilization (GO:0070935)2.86438339
40embryonic process involved in female pregnancy (GO:0060136)2.85563362
41adherens junction assembly (GO:0034333)2.81933181
42planar cell polarity pathway involved in neural tube closure (GO:0090179)2.79875241
43regulation of necrotic cell death (GO:0010939)2.77102707
44detection of other organism (GO:0098543)2.74804610
45barbed-end actin filament capping (GO:0051016)2.72983089
46macrophage activation involved in immune response (GO:0002281)2.72375305
47antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.71616611
48endodermal cell differentiation (GO:0035987)2.70673507
49detection of bacterium (GO:0016045)2.70546873
50negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.69692169
51semaphorin-plexin signaling pathway (GO:0071526)2.68924921
52activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.68699690
53positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.66811203
54cell adhesion mediated by integrin (GO:0033627)2.66035544
55basement membrane organization (GO:0071711)2.65898425
56modulation by virus of host process (GO:0019054)2.65849528
57cortical actin cytoskeleton organization (GO:0030866)2.65683308
58regulation of gamma-delta T cell activation (GO:0046643)2.65437427
59regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.65192115
60focal adhesion assembly (GO:0048041)2.63514797
61cell-substrate adherens junction assembly (GO:0007045)2.63514797
62COPI coating of Golgi vesicle (GO:0048205)2.62804899
63Golgi transport vesicle coating (GO:0048200)2.62804899
64positive regulation of triglyceride biosynthetic process (GO:0010867)2.61372233
65regulation of early endosome to late endosome transport (GO:2000641)2.61160569
66positive regulation of gamma-delta T cell activation (GO:0046645)2.60559348
67protein heterotrimerization (GO:0070208)2.59460930
68positive regulation of blood vessel endothelial cell migration (GO:0043536)2.59179627
69regulation of necroptotic process (GO:0060544)2.58170833
70response to fluid shear stress (GO:0034405)2.57443098
71positive regulation of fatty acid beta-oxidation (GO:0032000)2.57279436
72vascular endothelial growth factor signaling pathway (GO:0038084)2.56475195
73negative regulation of necrotic cell death (GO:0060547)2.55090083
744-hydroxyproline metabolic process (GO:0019471)2.54728474
75negative regulation of lipid transport (GO:0032369)2.54263742
76positive regulation of nuclease activity (GO:0032075)2.53124461
77cytoskeletal anchoring at plasma membrane (GO:0007016)2.52501124
78cellular response to virus (GO:0098586)2.50947574
79negative regulation of myotube differentiation (GO:0010832)2.50870334
80regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.50723257
81regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.50690072
82plasma membrane repair (GO:0001778)2.50667413
83regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.49856596
84regulation of glucose import in response to insulin stimulus (GO:2001273)2.49028673
85regulation of interleukin-12 biosynthetic process (GO:0045075)2.48902124
86stress fiber assembly (GO:0043149)2.48077655
87protein retention in ER lumen (GO:0006621)2.47553082
88epithelial cell differentiation involved in prostate gland development (GO:0060742)2.47328238
89negative regulation of necroptotic process (GO:0060546)2.47038983
90JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.46727731
91response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.44602508
92response to host (GO:0075136)2.44602508
93response to host defenses (GO:0052200)2.44602508
94detection of external biotic stimulus (GO:0098581)2.42957419
95regulation of mammary gland epithelial cell proliferation (GO:0033599)2.42715751
96positive thymic T cell selection (GO:0045059)2.42520703
97activation of Rac GTPase activity (GO:0032863)2.41912399
98germinal center formation (GO:0002467)2.41730343
99pentose-phosphate shunt (GO:0006098)2.41715269
100regulation of leukocyte degranulation (GO:0043300)2.41086591
101morphogenesis of an endothelium (GO:0003159)2.38988816
102endothelial tube morphogenesis (GO:0061154)2.38988816
103positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.38858649
104endoplasmic reticulum unfolded protein response (GO:0030968)2.38438586
105lipopolysaccharide-mediated signaling pathway (GO:0031663)2.38427157
106growth hormone receptor signaling pathway (GO:0060396)2.38177934
107negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.38177638
108retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.37205361
109negative regulation of interleukin-12 production (GO:0032695)2.36749980
110thymic T cell selection (GO:0045061)2.36709557
111vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.34507408
112regulation of T-helper 2 cell differentiation (GO:0045628)2.33836751
113regulation of NFAT protein import into nucleus (GO:0051532)2.31588429
114detection of molecule of bacterial origin (GO:0032490)2.31427152
115negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.30360461
116natural killer cell differentiation (GO:0001779)2.29861358
117regulation of ARF protein signal transduction (GO:0032012)2.29775076
118regulation of extracellular matrix organization (GO:1903053)2.29243195
119positive regulation of myotube differentiation (GO:0010831)2.29108514
120cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.28247766
121response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.27596532
122response to host immune response (GO:0052572)2.27596532
123positive regulation of extracellular matrix organization (GO:1903055)2.27301490
124negative regulation of toll-like receptor signaling pathway (GO:0034122)2.26800742
125histone H3-K36 demethylation (GO:0070544)2.25681294
126coronary vasculature morphogenesis (GO:0060977)2.25476326
127negative regulation of viral release from host cell (GO:1902187)2.24957715
128regulation of nuclease activity (GO:0032069)2.24780143
129cellular response to unfolded protein (GO:0034620)2.22936783
130germ cell migration (GO:0008354)2.22019673
131ER-nucleus signaling pathway (GO:0006984)2.21271286
132detection of biotic stimulus (GO:0009595)2.19752963
133negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.19543372
134activation of MAPKKK activity (GO:0000185)2.19077445
135negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.18595115
136negative regulation of cell killing (GO:0031342)2.18595115
137leukocyte aggregation (GO:0070486)2.17813571
138cell-cell junction maintenance (GO:0045217)2.17747878
139valine metabolic process (GO:0006573)2.16661553
140protein carboxylation (GO:0018214)2.16534959
141peptidyl-glutamic acid carboxylation (GO:0017187)2.16534959
142negative regulation of fibrinolysis (GO:0051918)2.16346643
143regulation of myeloid leukocyte mediated immunity (GO:0002886)2.16197108
144negative regulation of granulocyte differentiation (GO:0030853)2.16015000
145cortical cytoskeleton organization (GO:0030865)2.15921315
146sulfur amino acid catabolic process (GO:0000098)2.14173778
147regulation of integrin activation (GO:0033623)2.14122249
148insulin-like growth factor receptor signaling pathway (GO:0048009)2.11945424
149maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.11421395
150negative regulation of stress fiber assembly (GO:0051497)2.09332594
151mRNA stabilization (GO:0048255)2.09067564
152RNA stabilization (GO:0043489)2.09067564
153regulation of type I interferon-mediated signaling pathway (GO:0060338)2.08094638
154regulation of ARF GTPase activity (GO:0032312)2.07833333
155pinocytosis (GO:0006907)2.07224945
156negative regulation of innate immune response (GO:0045824)2.06898538
157negative regulation of bone resorption (GO:0045779)2.06743021
158epithelial cell-cell adhesion (GO:0090136)2.06646950
159blood vessel endothelial cell migration (GO:0043534)2.06373857
160regulation of interferon-beta biosynthetic process (GO:0045357)2.05753288
161activation of JUN kinase activity (GO:0007257)2.04935120
162substrate-dependent cell migration (GO:0006929)2.04143669
163cellular response to nutrient (GO:0031670)2.03916933
164regulation of membrane protein ectodomain proteolysis (GO:0051043)2.03068754
165receptor catabolic process (GO:0032801)2.02618614
166apoptotic process involved in morphogenesis (GO:0060561)2.02499083
167positive regulation of natural killer cell differentiation (GO:0032825)2.02364684

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.24485134
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.16054746
3MYC_22102868_ChIP-Seq_BL_Human2.70960483
4VDR_21846776_ChIP-Seq_THP-1_Human2.68886267
5KDM2B_26808549_Chip-Seq_SUP-B15_Human2.63336766
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.56191624
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.53960436
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.49059850
9ELK3_25401928_ChIP-Seq_HUVEC_Human2.48324280
10KDM2B_26808549_Chip-Seq_DND41_Human2.46279007
11* LXR_22292898_ChIP-Seq_THP-1_Human2.45175205
12* TCF7_22412390_ChIP-Seq_EML_Mouse2.43985808
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.36836401
14KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.23021352
15PPARA_22158963_ChIP-Seq_LIVER_Mouse2.07650629
16TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03972065
17CLOCK_20551151_ChIP-Seq_293T_Human2.03735654
18RXR_22158963_ChIP-Seq_LIVER_Mouse2.02411127
19* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.02343550
20STAT6_21828071_ChIP-Seq_BEAS2B_Human2.00709293
21* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.91613131
22* MAF_26560356_Chip-Seq_TH1_Human1.85847657
23TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.82232026
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.82006560
25RACK7_27058665_Chip-Seq_MCF-7_Human1.81718621
26STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.81199474
27ZNF263_19887448_ChIP-Seq_K562_Human1.79919192
28RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.79203607
29BP1_19119308_ChIP-ChIP_Hs578T_Human1.78782625
30TRIM28_21343339_ChIP-Seq_HEK293_Human1.78428321
31* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.77501033
32VDR_24763502_ChIP-Seq_THP-1_Human1.76229111
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.74745534
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.71426982
35IRF8_22096565_ChIP-ChIP_GC-B_Human1.70250627
36UTX_26944678_Chip-Seq_JUKART_Human1.68930763
37KDM2B_26808549_Chip-Seq_JURKAT_Human1.67774419
38* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.67244778
39LXR_22158963_ChIP-Seq_LIVER_Mouse1.63071131
40* KDM2B_26808549_Chip-Seq_K562_Human1.58598546
41SCL_19346495_ChIP-Seq_HPC-7_Human1.57476774
42P300_27058665_Chip-Seq_ZR-75-30cells_Human1.56273216
43NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.55734843
44SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53571206
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.52354636
46MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.51169592
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.49277636
48ATF3_27146783_Chip-Seq_COLON_Human1.49149217
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.47363524
50MYB_21317192_ChIP-Seq_ERMYB_Mouse1.47035046
51KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.46016057
52ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.44497499
53NCOR1_26117541_ChIP-Seq_K562_Human1.43020471
54IRF8_27001747_Chip-Seq_BMDM_Mouse1.37434283
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.37269891
56TET1_21451524_ChIP-Seq_MESCs_Mouse1.34394592
57TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34138795
58CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31127035
59UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30256973
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30135514
61TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.29523874
62ZFP281_18757296_ChIP-ChIP_E14_Mouse1.28699344
63SMC4_20622854_ChIP-Seq_HELA_Human1.28671736
64DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28127749
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28084396
66CREB1_26743006_Chip-Seq_LNCaP_Human1.27806940
67MAF_26560356_Chip-Seq_TH2_Human1.27288799
68RUNX1_22412390_ChIP-Seq_EML_Mouse1.26610011
69RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.26197736
70WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25816270
71IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.25439906
72CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.25127906
73GATA1_19941826_ChIP-Seq_K562_Human1.24312876
74* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.23856805
75ZFP281_27345836_Chip-Seq_ESCs_Mouse1.23636946
76SPI1_23127762_ChIP-Seq_K562_Human1.23194755
77EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22894243
78HIF1A_21447827_ChIP-Seq_MCF-7_Human1.22490571
79SA1_27219007_Chip-Seq_ERYTHROID_Human1.22421599
80* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21854725
81KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21661058
82DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20898976
83FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.19752927
84ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.18103679
85* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16010454
86TP53_22127205_ChIP-Seq_IMR90_Human1.14551483
87* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.13959074
88RUNX1_27514584_Chip-Seq_MCF-7_Human1.12321720
89MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10948204
90TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09818649
91ESR1_21235772_ChIP-Seq_MCF-7_Human1.09439200
92GATA1_19941827_ChIP-Seq_MEL_Mouse1.08713963
93FOXO3_23340844_ChIP-Seq_DLD1_Human1.08278503
94EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.07735018
95TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.07082336
96NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.06822667
97GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06707815
98UBF1/2_26484160_Chip-Seq_HMECs_Human1.05764540
99NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05709045
100BCOR_27268052_Chip-Seq_Bcells_Human1.05433579
101* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05123494
102CTCF_21964334_ChIP-Seq_BJAB-B_Human1.03490659
103P68_20966046_ChIP-Seq_HELA_Human1.02874579
104SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02575504
105SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01711211
106* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01642796
107* TBX20_22328084_ChIP-Seq_HEART_Mouse1.01476098
108* TBX20_22080862_ChIP-Seq_HEART_Mouse1.01476098
109CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01378662
110FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.01294375
111CTCF_21964334_Chip-Seq_Bcells_Human1.01270020
112MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00316437
113STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00090787
114DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.00066566
115CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99969824
116P63_26484246_Chip-Seq_KERATINOCYTES_Human0.99092949
117* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98207757
118GATA2_21666600_ChIP-Seq_HMVEC_Human0.97854830
119ELF1_20517297_ChIP-Seq_JURKAT_Human0.96944963
120CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96583471
121STAT4_19710469_ChIP-ChIP_TH1__Mouse0.96141839
122NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95365259
123BCL6_27268052_Chip-Seq_Bcells_Human0.95183240
124* MYB_26560356_Chip-Seq_TH1_Human0.94863976
125SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.93298283

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.16242089
2MP0008438_abnormal_cutaneous_collagen3.41769253
3MP0005451_abnormal_body_composition3.16866024
4MP0003303_peritoneal_inflammation3.11569691
5MP0003300_gastrointestinal_ulcer2.81394355
6MP0003566_abnormal_cell_adhesion2.62778788
7MP0009278_abnormal_bone_marrow2.54310677
8MP0004510_myositis2.37833107
9MP0008260_abnormal_autophagy2.30846133
10MP0004858_abnormal_nervous_system2.16069623
11MP0003191_abnormal_cellular_cholesterol2.10426007
12MP0005275_abnormal_skin_tensile2.09631264
13MP0009840_abnormal_foam_cell2.03823736
14MP0003279_aneurysm1.88634064
15MP0003436_decreased_susceptibility_to1.84216187
16MP0000685_abnormal_immune_system1.71560058
17MP0001958_emphysema1.64141606
18MP0000733_abnormal_muscle_development1.61095940
19MP0003763_abnormal_thymus_physiology1.60463317
20MP0005409_darkened_coat_color1.59208479
21MP0005076_abnormal_cell_differentiation1.59197911
22MP0005023_abnormal_wound_healing1.54656408
23MP0005058_abnormal_lysosome_morphology1.54488768
24MP0004947_skin_inflammation1.48689956
25MP0010368_abnormal_lymphatic_system1.46981269
26MP0010352_gastrointestinal_tract_polyps1.45031890
27MP0004185_abnormal_adipocyte_glucose1.44746189
28MP0002877_abnormal_melanocyte_morpholog1.44671516
29MP0003329_amyloid_beta_deposits1.44581284
30MP0005623_abnormal_meninges_morphology1.42807603
31MP0003453_abnormal_keratinocyte_physiol1.41740222
32MP0010234_abnormal_vibrissa_follicle1.40226029
33MP0006054_spinal_hemorrhage1.38562789
34MP0002254_reproductive_system_inflammat1.38453076
35MP0001348_abnormal_lacrimal_gland1.37042822
36MP0003091_abnormal_cell_migration1.36616909
37MP0005666_abnormal_adipose_tissue1.31880011
38MP0004130_abnormal_muscle_cell1.31660083
39MP0008961_abnormal_basal_metabolism1.31418884
40MP0003252_abnormal_bile_duct1.31103420
41MP0005257_abnormal_intraocular_pressure1.30255491
42MP0003045_fibrosis1.29714325
43MP0002139_abnormal_hepatobiliary_system1.27900673
44MP0002060_abnormal_skin_morphology1.26884817
45MP0006082_CNS_inflammation1.23538474
46MP0001835_abnormal_antigen_presentation1.22931526
47MP0000767_abnormal_smooth_muscle1.20843875
48MP0003183_abnormal_peptide_metabolism1.19273284
49MP0005375_adipose_tissue_phenotype1.19237154
50MP0005397_hematopoietic_system_phenotyp1.18010650
51MP0001545_abnormal_hematopoietic_system1.18010650
52MP0001533_abnormal_skeleton_physiology1.17993826
53MP0000465_gastrointestinal_hemorrhage1.16249639
54MP0000604_amyloidosis1.15928367
55MP0005464_abnormal_platelet_physiology1.12551247
56MP0000678_abnormal_parathyroid_gland1.11257389
57MP0010155_abnormal_intestine_physiology1.10828484
58MP0004808_abnormal_hematopoietic_stem1.09751742
59MP0005360_urolithiasis1.09121658
60MP0001849_ear_inflammation1.07612400
61MP0000747_muscle_weakness1.06894928
62MP0010630_abnormal_cardiac_muscle1.06277238
63MP0004087_abnormal_muscle_fiber1.05808154
64MP0003828_pulmonary_edema1.05176191
65MP0005167_abnormal_blood-brain_barrier1.04015026
66MP0002933_joint_inflammation1.03925382
67MP0001851_eye_inflammation1.03564237
68MP0000003_abnormal_adipose_tissue1.03148940
69MP0002998_abnormal_bone_remodeling1.02997515
70MP0004272_abnormal_basement_membrane1.02710042
71MP0001790_abnormal_immune_system1.02188735
72MP0005387_immune_system_phenotype1.02188735
73MP0005083_abnormal_biliary_tract1.02120762
74MP0004233_abnormal_muscle_weight1.00709858
75MP0001879_abnormal_lymphatic_vessel0.99838783
76MP0000537_abnormal_urethra_morphology0.99563041
77MP0003172_abnormal_lysosome_physiology0.99558558
78MP0002166_altered_tumor_susceptibility0.99255871
79MP0005025_abnormal_response_to0.99154748
80MP0000343_altered_response_to0.98807271
81MP0002396_abnormal_hematopoietic_system0.96734454
82MP0000609_abnormal_liver_physiology0.96674264
83MP0001853_heart_inflammation0.96584480
84MP0003448_altered_tumor_morphology0.96409435
85MP0000716_abnormal_immune_system0.96193312
86MP0002398_abnormal_bone_marrow0.95861043
87MP0005621_abnormal_cell_physiology0.95127777
88MP0000751_myopathy0.94101621
89MP0000750_abnormal_muscle_regeneration0.92709508
90MP0000858_altered_metastatic_potential0.92600186
91MP0005000_abnormal_immune_tolerance0.92219826
92MP0000490_abnormal_crypts_of0.91596262
93MP0002148_abnormal_hypersensitivity_rea0.91507351
94MP0002419_abnormal_innate_immunity0.90498560
95MP0002452_abnormal_antigen_presenting0.89380268
96MP0004264_abnormal_extraembryonic_tissu0.86656843
97MP0001800_abnormal_humoral_immune0.86466002
98MP0001915_intracranial_hemorrhage0.85912181
99MP0000703_abnormal_thymus_morphology0.85550379
100MP0003075_altered_response_to0.85320406
101MP0002128_abnormal_blood_circulation0.83495358
102MP0003724_increased_susceptibility_to0.82712962
103MP0002429_abnormal_blood_cell0.82053174
104MP0000598_abnormal_liver_morphology0.81952995
105MP0002089_abnormal_postnatal_growth/wei0.81557864
106MP0001243_abnormal_dermal_layer0.81415836
107MP0009785_altered_susceptibility_to0.81162505
108MP0004084_abnormal_cardiac_muscle0.79641670
109MP0000249_abnormal_blood_vessel0.79491005
110MP0010307_abnormal_tumor_latency0.79392775
111MP0001845_abnormal_inflammatory_respons0.79035231
112MP0002796_impaired_skin_barrier0.78388582
113MP0002722_abnormal_immune_system0.78386261
114MP0004381_abnormal_hair_follicle0.77919867
115MP0002405_respiratory_system_inflammati0.77436678
116MP0005501_abnormal_skin_physiology0.76499945
117MP0009384_cardiac_valve_regurgitation0.76471641
118MP0005670_abnormal_white_adipose0.76114439
119MP0002249_abnormal_larynx_morphology0.75974240
120MP0001873_stomach_inflammation0.75552478
121MP0001819_abnormal_immune_cell0.75006467
122MP0009931_abnormal_skin_appearance0.74793009
123MP0002420_abnormal_adaptive_immunity0.74704646
124MP0002723_abnormal_immune_serum0.74118527
125MP0005390_skeleton_phenotype0.72856679
126MP0003866_abnormal_defecation0.71537036
127MP0002896_abnormal_bone_mineralization0.71395245
128MP0000759_abnormal_skeletal_muscle0.71359834
129MP0001614_abnormal_blood_vessel0.70446755
130MP0010329_abnormal_lipoprotein_level0.70192193
131MP0009333_abnormal_splenocyte_physiolog0.69849855

Predicted human phenotypes

RankGene SetZ-score
1Cerebral aneurysm (HP:0004944)4.24245456
2Premature rupture of membranes (HP:0001788)4.13731724
3Protrusio acetabuli (HP:0003179)4.10272760
4Peritonitis (HP:0002586)3.24730196
5Aortic aneurysm (HP:0004942)3.02540409
6Shallow orbits (HP:0000586)2.99742671
7Mitral valve prolapse (HP:0001634)2.97890492
8Myocardial infarction (HP:0001658)2.92771479
9Hyperacusis (HP:0010780)2.88784497
10Increased connective tissue (HP:0009025)2.80675615
11Aortic dissection (HP:0002647)2.80435174
12Achilles tendon contracture (HP:0001771)2.77685442
13Aneurysm (HP:0002617)2.73505717
14Abnormality of the Achilles tendon (HP:0005109)2.72519681
15Broad face (HP:0000283)2.64893992
16Ulnar bowing (HP:0003031)2.62347450
17Abnormality of the nasal mucosa (HP:0000433)2.61107590
18Upper limb amyotrophy (HP:0009129)2.57057155
19Distal upper limb amyotrophy (HP:0007149)2.57057155
20Bladder diverticulum (HP:0000015)2.50190350
21Deep venous thrombosis (HP:0002625)2.49491063
22Broad metatarsal (HP:0001783)2.46221725
23Asymmetric septal hypertrophy (HP:0001670)2.45893241
24Dilatation of the ascending aorta (HP:0005111)2.43321328
25Nasal polyposis (HP:0100582)2.41297982
26Fragile skin (HP:0001030)2.37944534
27Abnormality of macrophages (HP:0004311)2.37749891
28Increased cerebral lipofuscin (HP:0011813)2.36246827
29Difficulty climbing stairs (HP:0003551)2.36043497
30Obstructive sleep apnea (HP:0002870)2.32275103
31Type 1 muscle fiber predominance (HP:0003803)2.30829179
32Flat acetabular roof (HP:0003180)2.27115655
33Abnormality of glycolipid metabolism (HP:0010969)2.25027096
34Abnormality of liposaccharide metabolism (HP:0010968)2.25027096
35Abnormality of glycosphingolipid metabolism (HP:0004343)2.25027096
36Centrally nucleated skeletal muscle fibers (HP:0003687)2.24830715
37Increased variability in muscle fiber diameter (HP:0003557)2.22794450
38Impaired platelet aggregation (HP:0003540)2.22435045
39Abnormal platelet function (HP:0011869)2.22435045
40Bowing of the arm (HP:0006488)2.20988511
41Bowed forearm bones (HP:0003956)2.20988511
42Xanthomatosis (HP:0000991)2.19267508
43Ankle contracture (HP:0006466)2.18457000
44Mildly elevated creatine phosphokinase (HP:0008180)2.18320951
45Thin bony cortex (HP:0002753)2.18292866
46Atrophic scars (HP:0001075)2.17897881
47Hand muscle atrophy (HP:0009130)2.16768363
48Radial bowing (HP:0002986)2.15421173
49Hemorrhage of the eye (HP:0011885)2.11788283
50Lymphangioma (HP:0100764)2.11171103
51Cerebral inclusion bodies (HP:0100314)2.10747570
52Recurrent abscess formation (HP:0002722)2.10745280
53Neurofibrillary tangles (HP:0002185)2.10571514
54Increased density of long bones (HP:0006392)2.10050302
55Abnormality of skeletal muscle fiber size (HP:0012084)2.09643880
56Recurrent bacterial skin infections (HP:0005406)2.07118070
57Hematochezia (HP:0002573)2.06020529
58Colitis (HP:0002583)2.04459223
59Eczematoid dermatitis (HP:0000976)2.03368267
60Difficulty running (HP:0009046)2.02983180
61Genu recurvatum (HP:0002816)2.02714686
62Segmental peripheral demyelination/remyelination (HP:0003481)2.01901285
63Abnormality of the peritoneum (HP:0002585)2.00957843
64Gingivitis (HP:0000230)2.00276566
65Hyporeflexia of lower limbs (HP:0002600)1.99046937
66Interstitial pulmonary disease (HP:0006530)1.98920413
67Disproportionate tall stature (HP:0001519)1.97857710
68Recurrent gram-negative bacterial infections (HP:0005420)1.97431134
69Polycythemia (HP:0001901)1.97294971
70Abnormality of the distal phalanx of the thumb (HP:0009617)1.95605640
71Mediastinal lymphadenopathy (HP:0100721)1.94932687
72Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.94484429
73Bowel diverticulosis (HP:0005222)1.92983135
74Turricephaly (HP:0000262)1.92494556
75Right ventricular cardiomyopathy (HP:0011663)1.91339911
76Arterial tortuosity (HP:0005116)1.91291392
77Menorrhagia (HP:0000132)1.89334052
78Increased IgE level (HP:0003212)1.89109962
79Blue sclerae (HP:0000592)1.88431135
80Round ear (HP:0100830)1.88151069
81Distal lower limb muscle weakness (HP:0009053)1.87558698
82Abnormal platelet volume (HP:0011876)1.87153840
83Spontaneous hematomas (HP:0007420)1.87068406
84Osteolytic defects of the hand bones (HP:0009699)1.86852629
85Osteolytic defects of the phalanges of the hand (HP:0009771)1.86852629
86Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.86823464
87Increased mean platelet volume (HP:0011877)1.86325527
88Long toe (HP:0010511)1.84894731
89Cervical subluxation (HP:0003308)1.84668349
90Subacute progressive viral hepatitis (HP:0006572)1.83243238
91Loss of speech (HP:0002371)1.82888537
92Biconcave vertebral bodies (HP:0004586)1.82821864
93Gastrointestinal inflammation (HP:0004386)1.82566194
94Hallux valgus (HP:0001822)1.82466280
95Increased neuronal autofluorescent lipopigment (HP:0002074)1.82464268
96Spinal cord lesions (HP:0100561)1.82084434
97Syringomyelia (HP:0003396)1.82084434
98Camptodactyly of toe (HP:0001836)1.82058739
99Abnormality of the thoracic spine (HP:0100711)1.81976899
100Systemic lupus erythematosus (HP:0002725)1.81524737
101Vascular tortuosity (HP:0004948)1.80795159
102Thrombocytosis (HP:0001894)1.80640711
103Renal duplication (HP:0000075)1.80394938
104Distal lower limb amyotrophy (HP:0008944)1.79711371
105Back pain (HP:0003418)1.78989553
106Scapular winging (HP:0003691)1.78980007
107Polygenic inheritance (HP:0010982)1.78792932
108Metaphyseal cupping (HP:0003021)1.78758415
109Renovascular hypertension (HP:0100817)1.78667802
110Generalized amyotrophy (HP:0003700)1.78511978
111Deviation of the hallux (HP:0010051)1.78387171
112Hypercortisolism (HP:0001578)1.77229505
113Mucopolysacchariduria (HP:0008155)1.76824642
114Urinary glycosaminoglycan excretion (HP:0003541)1.76824642
115Striae distensae (HP:0001065)1.76471041
116Neuronal loss in central nervous system (HP:0002529)1.75979230
117Abnormality of mucopolysaccharide metabolism (HP:0011020)1.75508848
118Abnormality of polysaccharide metabolism (HP:0011012)1.75508848
119Abnormality of glycosaminoglycan metabolism (HP:0004371)1.75508848
120Persistence of primary teeth (HP:0006335)1.74934266
121Elfin facies (HP:0004428)1.74744874
122Cellulitis (HP:0100658)1.74374889
123Elevated erythrocyte sedimentation rate (HP:0003565)1.73801265
124Emphysema (HP:0002097)1.73229182
125Inflammation of the large intestine (HP:0002037)1.73022593
126Short nail (HP:0001799)1.73009345
127Ectopia lentis (HP:0001083)1.72939489
128Myositis (HP:0100614)1.72345011
129Long palpebral fissure (HP:0000637)1.72151798
130Insomnia (HP:0100785)1.71780682
131Obstructive lung disease (HP:0006536)1.71704083
132Chronic obstructive pulmonary disease (HP:0006510)1.71704083
133Nephritis (HP:0000123)1.71319953
134Spinal rigidity (HP:0003306)1.70854590
135Dysostosis multiplex (HP:0000943)1.69224723
136Amyloidosis (HP:0011034)1.68763847
137Vertebral compression fractures (HP:0002953)1.67784464
138Abnormality of complement system (HP:0005339)1.67605705
139Mitral regurgitation (HP:0001653)1.67505798
140Rectal prolapse (HP:0002035)1.66572907
141Wormian bones (HP:0002645)1.66047046
142Bone pain (HP:0002653)1.65558561
143Limb-girdle muscle atrophy (HP:0003797)1.64176746
144Arnold-Chiari malformation (HP:0002308)1.63771649
145Abnormality of the fingertips (HP:0001211)1.63749028
146Thoracic kyphosis (HP:0002942)1.62421725
147Abnormal ossification of hand bones (HP:0005921)1.58336895
148Premature skin wrinkling (HP:0100678)1.57752806
149Nuclear cataract (HP:0100018)1.56659646
150Orchitis (HP:0100796)1.56286896
151J-shaped sella turcica (HP:0002680)1.55292892
152Spondylolisthesis (HP:0003302)1.53798039
153Purpura (HP:0000979)1.53787612
154Supranuclear gaze palsy (HP:0000605)1.53211093

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.36543774
2PKN24.11706511
3ERN13.41349621
4PRPF4B3.24748430
5EEF2K3.12900482
6SMG12.75780873
7TTN2.52743744
8MAP3K102.49241276
9PTK62.27312433
10MAP4K11.89758256
11RIPK11.86646646
12LRRK21.83246550
13SIK11.80731939
14ICK1.80637424
15MAP3K131.79347314
16EPHB11.75871223
17BMX1.68470152
18TGFBR21.68354026
19PDGFRA1.61951025
20FGFR41.61172836
21TBK11.60018041
22BLK1.50818388
23TYK21.40389317
24IRAK41.38115111
25DDR21.34427832
26PAK41.31988766
27MAP2K31.24914078
28MAP3K71.24553567
29TAOK21.24180762
30MAP3K11.22445259
31DMPK1.21223352
32EPHA21.21212380
33SCYL21.21071676
34CDC42BPA1.19864585
35JAK11.17142803
36PTK21.16997612
37DYRK1B1.16107644
38RIPK41.16056188
39SIK21.12881991
40MAP3K141.12678778
41CSK1.12587746
42ZAP701.12334958
43CDK121.09547979
44FLT31.07192398
45KSR21.06251836
46CSF1R0.99632554
47MAP3K60.99027821
48TAOK10.98149584
49GRK60.94801972
50TAOK30.94635359
51MTOR0.93411407
52ALK0.93018641
53ILK0.91904145
54JAK30.90648528
55PAK20.89449973
56HIPK20.88548569
57CDK60.86206830
58HCK0.84005164
59PRKD20.82647960
60STK100.79459460
61RET0.78852854
62FGFR30.76293027
63JAK20.76150151
64EPHB20.75981963
65IKBKE0.75937792
66CAMK1D0.74669126
67ARAF0.74606507
68IRAK20.74025130
69FER0.73478551
70TYRO30.72688366
71BTK0.70673506
72MST1R0.70470445
73MAP2K20.69902335
74MARK20.68927702
75NTRK10.68358046
76PRKD10.67688510
77NEK90.67595218
78PDGFRB0.66694652
79KIT0.65932781
80RPS6KA40.65400596
81PDPK10.65198322
82IRAK30.65170895
83CAMK1G0.65014806
84MAPKAPK30.64870046
85MAP3K110.64236981
86FES0.63750152
87IKBKB0.62186533
88EPHA30.61045695
89MAPK120.61007743
90PDK10.59898197
91KDR0.58806611
92MAPK110.58775181
93MATK0.57486711
94TESK20.57076142
95PRKG20.56946164
96MOS0.56871339
97TLK10.56116794
98STK380.55483742
99MAP3K30.55404474
100CHUK0.54470878
101RPS6KB20.54397546
102DAPK30.53989334
103SGK30.53838136
104TESK10.53589938
105SIK30.52961067
106PIM10.51878490
107RPS6KA60.51650962
108BCKDK0.49800881
109FGR0.49396411
110RPS6KA20.49339120
111PRKCH0.48881385
112NME20.48406464
113GSK3A0.48257543
114MAP3K80.47327086
115LATS20.46776154
116CDK40.46564502
117RPS6KC10.46292972
118RPS6KL10.46292972
119TNK20.45362545
120CAMKK10.43182831
121PRKAA20.42673863
122ITK0.42556979
123PIM20.42082195
124MAPK70.41265013
125RPS6KA10.40932181
126LCK0.40750306
127TRPM70.40517923
128LMTK20.40395505

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.25241254
2Chronic myeloid leukemia_Homo sapiens_hsa052201.95527409
3Staphylococcus aureus infection_Homo sapiens_hsa051501.79782340
4Osteoclast differentiation_Homo sapiens_hsa043801.77293387
5B cell receptor signaling pathway_Homo sapiens_hsa046621.63778290
6Leishmaniasis_Homo sapiens_hsa051401.60122959
7Acute myeloid leukemia_Homo sapiens_hsa052211.57532938
8AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.57208609
9Insulin resistance_Homo sapiens_hsa049311.56426811
10Focal adhesion_Homo sapiens_hsa045101.53350034
11Glycosaminoglycan degradation_Homo sapiens_hsa005311.50990955
12Nitrogen metabolism_Homo sapiens_hsa009101.48162149
13Bladder cancer_Homo sapiens_hsa052191.44633708
14Proteoglycans in cancer_Homo sapiens_hsa052051.40830148
15Toxoplasmosis_Homo sapiens_hsa051451.39905975
16Adipocytokine signaling pathway_Homo sapiens_hsa049201.37005067
17Amoebiasis_Homo sapiens_hsa051461.36398151
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.34300300
19ECM-receptor interaction_Homo sapiens_hsa045121.34189688
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.31747654
21Complement and coagulation cascades_Homo sapiens_hsa046101.30134253
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.27234674
23Leukocyte transendothelial migration_Homo sapiens_hsa046701.26401546
24Platelet activation_Homo sapiens_hsa046111.25833493
25Small cell lung cancer_Homo sapiens_hsa052221.24388884
26Lysine degradation_Homo sapiens_hsa003101.22417389
27Prion diseases_Homo sapiens_hsa050201.19565594
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.19516388
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.18689125
30Notch signaling pathway_Homo sapiens_hsa043301.18522554
31VEGF signaling pathway_Homo sapiens_hsa043701.15186529
32PPAR signaling pathway_Homo sapiens_hsa033201.13289807
33Sulfur relay system_Homo sapiens_hsa041221.11439509
34Pancreatic cancer_Homo sapiens_hsa052121.11239843
35Arginine biosynthesis_Homo sapiens_hsa002201.10179799
36Central carbon metabolism in cancer_Homo sapiens_hsa052301.10078391
37mTOR signaling pathway_Homo sapiens_hsa041501.09735432
38Galactose metabolism_Homo sapiens_hsa000521.08465511
39ErbB signaling pathway_Homo sapiens_hsa040121.07259302
40Lysosome_Homo sapiens_hsa041421.06682478
41Fatty acid degradation_Homo sapiens_hsa000711.06273543
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.04966354
43Neurotrophin signaling pathway_Homo sapiens_hsa047221.03150243
44Toll-like receptor signaling pathway_Homo sapiens_hsa046201.02644085
45Fructose and mannose metabolism_Homo sapiens_hsa000511.01672918
46GnRH signaling pathway_Homo sapiens_hsa049121.01087395
47Colorectal cancer_Homo sapiens_hsa052101.00688913
48Apoptosis_Homo sapiens_hsa042101.00353083
49TNF signaling pathway_Homo sapiens_hsa046681.00317174
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.98638920
51Other glycan degradation_Homo sapiens_hsa005110.98437999
52Non-small cell lung cancer_Homo sapiens_hsa052230.96134342
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.95255600
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.95190015
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.95044109
56Antigen processing and presentation_Homo sapiens_hsa046120.94984284
57Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93194717
58Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.92744581
59Prolactin signaling pathway_Homo sapiens_hsa049170.92610987
60Salmonella infection_Homo sapiens_hsa051320.89846381
61Choline metabolism in cancer_Homo sapiens_hsa052310.89807227
62Pentose phosphate pathway_Homo sapiens_hsa000300.89755078
63AMPK signaling pathway_Homo sapiens_hsa041520.89547802
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.89139684
65Thyroid cancer_Homo sapiens_hsa052160.87999204
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87590232
67Pertussis_Homo sapiens_hsa051330.87306863
68Shigellosis_Homo sapiens_hsa051310.86555643
69Insulin signaling pathway_Homo sapiens_hsa049100.85556204
70Viral myocarditis_Homo sapiens_hsa054160.84315041
71Tuberculosis_Homo sapiens_hsa051520.83717056
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.82612253
73MicroRNAs in cancer_Homo sapiens_hsa052060.82211609
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82007755
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81714574
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.81684873
77Adherens junction_Homo sapiens_hsa045200.81444698
78Dilated cardiomyopathy_Homo sapiens_hsa054140.81117132
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.79669048
80Herpes simplex infection_Homo sapiens_hsa051680.79395729
81Viral carcinogenesis_Homo sapiens_hsa052030.78743471
82Malaria_Homo sapiens_hsa051440.77593905
83Measles_Homo sapiens_hsa051620.76937543
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76735001
85Hepatitis B_Homo sapiens_hsa051610.75055206
86Bile secretion_Homo sapiens_hsa049760.74836401
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74034825
88Glioma_Homo sapiens_hsa052140.73994652
89Renal cell carcinoma_Homo sapiens_hsa052110.73802725
90Estrogen signaling pathway_Homo sapiens_hsa049150.73359930
91Chemokine signaling pathway_Homo sapiens_hsa040620.72596153
92Inositol phosphate metabolism_Homo sapiens_hsa005620.72532978
93ABC transporters_Homo sapiens_hsa020100.70078658
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69880521
95Jak-STAT signaling pathway_Homo sapiens_hsa046300.69401547
96Tryptophan metabolism_Homo sapiens_hsa003800.69078756
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68437556
98HIF-1 signaling pathway_Homo sapiens_hsa040660.67335843
99Selenocompound metabolism_Homo sapiens_hsa004500.66893006
100Hepatitis C_Homo sapiens_hsa051600.66694808
101T cell receptor signaling pathway_Homo sapiens_hsa046600.66416814
102Fat digestion and absorption_Homo sapiens_hsa049750.66055441
103MAPK signaling pathway_Homo sapiens_hsa040100.65226728
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64664217
105Starch and sucrose metabolism_Homo sapiens_hsa005000.64335912
106Endometrial cancer_Homo sapiens_hsa052130.64122184
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63567605
108FoxO signaling pathway_Homo sapiens_hsa040680.63449223
109Protein digestion and absorption_Homo sapiens_hsa049740.63381444
110Endocytosis_Homo sapiens_hsa041440.63332316
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60893317
112Influenza A_Homo sapiens_hsa051640.60842166
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60395617
114Phagosome_Homo sapiens_hsa041450.60277852
115Rap1 signaling pathway_Homo sapiens_hsa040150.60176174
116Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59842014
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.59061604
118Pathways in cancer_Homo sapiens_hsa052000.58441924
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58034078
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57841136
121RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57705916
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56445047
123Cyanoamino acid metabolism_Homo sapiens_hsa004600.55138687
124Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54335479
125HTLV-I infection_Homo sapiens_hsa051660.54308870
126Prostate cancer_Homo sapiens_hsa052150.53883969
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51860207
128Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49677840

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