LEMD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K36 demethylation (GO:0070544)5.29372101
2nuclear pore organization (GO:0006999)5.27671931
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.59964057
4negative regulation of cell killing (GO:0031342)4.59964057
5phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.45758597
6regulation of short-term neuronal synaptic plasticity (GO:0048172)4.35025543
7pore complex assembly (GO:0046931)4.15456038
8histone lysine demethylation (GO:0070076)3.96593477
9ionotropic glutamate receptor signaling pathway (GO:0035235)3.88564448
10histone demethylation (GO:0016577)3.84862845
11regulation of histone H3-K9 methylation (GO:0051570)3.72991523
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.72927339
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.72094890
14nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.71767776
15vocalization behavior (GO:0071625)3.70942809
16definitive hemopoiesis (GO:0060216)3.64402229
17locomotory exploration behavior (GO:0035641)3.64371497
18layer formation in cerebral cortex (GO:0021819)3.62513743
19Golgi to endosome transport (GO:0006895)3.60286097
20regulation of glutamate receptor signaling pathway (GO:1900449)3.56327461
21DNA synthesis involved in DNA repair (GO:0000731)3.49344749
22regulation of clathrin-mediated endocytosis (GO:2000369)3.47466577
23synaptic vesicle maturation (GO:0016188)3.46512136
24histone H3-K9 methylation (GO:0051567)3.44906770
25protein dealkylation (GO:0008214)3.44852346
26protein demethylation (GO:0006482)3.44852346
27histone H4-K16 acetylation (GO:0043984)3.41875929
28histone H3-K9 modification (GO:0061647)3.40925622
29positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.40575052
30regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.39970679
31positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.39970679
32glutamate receptor signaling pathway (GO:0007215)3.34238540
33vesicle transport along microtubule (GO:0047496)3.31919941
34protein localization to synapse (GO:0035418)3.31092671
35histone H3-K9 demethylation (GO:0033169)3.29340711
36regulation of chromatin binding (GO:0035561)3.28289450
37positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.28235737
38regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.28235737
39negative regulation of histone methylation (GO:0031061)3.27435089
40gamma-aminobutyric acid signaling pathway (GO:0007214)3.27258743
41cytoplasmic mRNA processing body assembly (GO:0033962)3.21690149
42dosage compensation (GO:0007549)3.20193013
43neuron cell-cell adhesion (GO:0007158)3.18447933
44protein localization to endosome (GO:0036010)3.14646860
45regulation of RNA export from nucleus (GO:0046831)3.14350559
46dendritic spine morphogenesis (GO:0060997)3.13498157
47regulation of B cell receptor signaling pathway (GO:0050855)3.12359841
48regulation of transforming growth factor beta2 production (GO:0032909)3.11097600
49regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.10927981
50peptidyl-lysine trimethylation (GO:0018023)3.08393514
51regulation of nucleobase-containing compound transport (GO:0032239)3.08232164
52G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.07883754
53regulation of synaptic vesicle exocytosis (GO:2000300)3.07059227
54exploration behavior (GO:0035640)3.06446427
55cellular potassium ion homeostasis (GO:0030007)3.03923207
56regulation of excitatory postsynaptic membrane potential (GO:0060079)3.02339917
57response to histamine (GO:0034776)3.00637308
58neuron recognition (GO:0008038)3.00332085
59positive regulation of fibroblast migration (GO:0010763)2.99747167
60synaptic vesicle exocytosis (GO:0016079)2.99448879
61positive regulation of mRNA catabolic process (GO:0061014)2.97466708
62histone H3-K4 trimethylation (GO:0080182)2.97422250
63sodium ion export (GO:0071436)2.96119345
64monoubiquitinated protein deubiquitination (GO:0035520)2.95336866
65negative regulation of inclusion body assembly (GO:0090084)2.94837869
66peptidyl-threonine phosphorylation (GO:0018107)2.93902316
67long-term memory (GO:0007616)2.90311416
68regulation of fibroblast apoptotic process (GO:2000269)2.89116043
69regulation of long-term neuronal synaptic plasticity (GO:0048169)2.87979092
70cerebellar Purkinje cell differentiation (GO:0021702)2.87589794
71alternative mRNA splicing, via spliceosome (GO:0000380)2.87175845
72regulation of dendritic spine morphogenesis (GO:0061001)2.85572325
73axonal fasciculation (GO:0007413)2.83936315
74positive regulation of mRNA 3-end processing (GO:0031442)2.82540948
75regulation of neuronal synaptic plasticity (GO:0048168)2.82510740
76positive regulation of synapse maturation (GO:0090129)2.80504195
77regulation of postsynaptic membrane potential (GO:0060078)2.80467738
78glutamate secretion (GO:0014047)2.79932353
79histone H4-K8 acetylation (GO:0043982)2.79094784
80histone H4-K5 acetylation (GO:0043981)2.79094784
81neuronal action potential propagation (GO:0019227)2.77313527
82proline transport (GO:0015824)2.76367771
83positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.75208891
84peptidyl-threonine modification (GO:0018210)2.74871715
85determination of adult lifespan (GO:0008340)2.74551095
86protein targeting to Golgi (GO:0000042)2.73054894
87negative regulation of NF-kappaB import into nucleus (GO:0042347)2.71438336
88neuromuscular process controlling balance (GO:0050885)2.70612133
89mitotic sister chromatid cohesion (GO:0007064)2.69612908
90regulation of mRNA catabolic process (GO:0061013)2.69462963
91histone H3-K4 methylation (GO:0051568)2.69386136
92regulation of histone H3-K27 methylation (GO:0061085)2.67969018
93sister chromatid cohesion (GO:0007062)2.66801811
94negative regulation of histone modification (GO:0031057)2.65650315
95neuron-neuron synaptic transmission (GO:0007270)2.65558144
96cerebellar granule cell differentiation (GO:0021707)2.65492162
97response to UV-C (GO:0010225)2.65169158
98regulation of ARF protein signal transduction (GO:0032012)2.64363678
99histone lysine methylation (GO:0034968)2.62966392
100synaptic transmission, glutamatergic (GO:0035249)2.61794035
101neurotransmitter secretion (GO:0007269)2.60747997
102response to muramyl dipeptide (GO:0032495)2.59862843
103organelle transport along microtubule (GO:0072384)2.58422695
104negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.58171627
105negative regulation of translation, ncRNA-mediated (GO:0040033)2.58171627
106regulation of translation, ncRNA-mediated (GO:0045974)2.58171627
107clathrin coat assembly (GO:0048268)2.56807494
108gene silencing by RNA (GO:0031047)2.56701538
109nerve growth factor signaling pathway (GO:0038180)2.56692470
110embryonic camera-type eye morphogenesis (GO:0048596)2.56647507
111protein K11-linked deubiquitination (GO:0035871)2.55131677
112regulation of NFAT protein import into nucleus (GO:0051532)2.54930746
113positive regulation of granulocyte differentiation (GO:0030854)2.54497022
114protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.53522168
115negative regulation of DNA repair (GO:0045738)2.53224368
116negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.52475331
117vitamin transmembrane transport (GO:0035461)2.51613099
118positive regulation of dendritic spine morphogenesis (GO:0061003)2.50988535
119long-term synaptic potentiation (GO:0060291)2.49983123
120cytoskeletal anchoring at plasma membrane (GO:0007016)2.49329045
121establishment of protein localization to Golgi (GO:0072600)2.48968711
122regulation of synaptic plasticity (GO:0048167)2.48256314
123peptidyl-threonine dephosphorylation (GO:0035970)2.45981264
124peptidyl-lysine methylation (GO:0018022)2.45596363
125positive regulation of mRNA processing (GO:0050685)2.45591057
126synaptic vesicle endocytosis (GO:0048488)2.45539041
127positive regulation of membrane potential (GO:0045838)2.45304566
128regulation of Rac protein signal transduction (GO:0035020)2.45296794
129regulation of vesicle fusion (GO:0031338)2.44798800
130mRNA splice site selection (GO:0006376)2.43751810
131neural tube formation (GO:0001841)2.43550585
132phospholipid translocation (GO:0045332)2.42212805
133lipid translocation (GO:0034204)2.42212805
134regulation of dendritic spine development (GO:0060998)2.42040308
135regulation of ARF GTPase activity (GO:0032312)2.41740980
136nucleus organization (GO:0006997)2.41273918
137glycosphingolipid biosynthetic process (GO:0006688)2.40914287
138positive regulation of gamma-delta T cell activation (GO:0046645)2.39898905
139protein K48-linked deubiquitination (GO:0071108)2.39740934
140histone H2B ubiquitination (GO:0033523)2.39599078
141dendrite morphogenesis (GO:0048813)2.39039900
142establishment of nucleus localization (GO:0040023)2.38654142
143positive regulation of macroautophagy (GO:0016239)2.38638834
144long term synaptic depression (GO:0060292)2.38457185
145regulation of synaptic vesicle transport (GO:1902803)2.38027040
146early endosome to late endosome transport (GO:0045022)2.37948587
147positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.37576323
148positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.37576323
149positive regulation of mitotic sister chromatid separation (GO:1901970)2.37576323
150negative regulation of chromatin modification (GO:1903309)2.37557285
1513-UTR-mediated mRNA stabilization (GO:0070935)2.36870688
152regulation of chromatin silencing (GO:0031935)2.36418914
153negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.36204216
154pre-miRNA processing (GO:0031054)2.35844076
155positive regulation of mRNA metabolic process (GO:1903313)2.35589477
156nuclear pore complex assembly (GO:0051292)2.35547432
157NLS-bearing protein import into nucleus (GO:0006607)2.35293886
158negative regulation of neurotransmitter secretion (GO:0046929)2.35076988
159histone methylation (GO:0016571)2.34394283
160snRNA transcription (GO:0009301)2.33918988
161negative regulation of smooth muscle cell differentiation (GO:0051151)2.32495852
162activation of protein kinase A activity (GO:0034199)2.32395584
163regulation of histone methylation (GO:0031060)2.31384154
164regulation of DNA endoreduplication (GO:0032875)2.30585277
165dendritic spine organization (GO:0097061)2.29781414
166behavioral fear response (GO:0001662)2.29470067
167behavioral defense response (GO:0002209)2.29470067
168positive regulation of DNA-templated transcription, initiation (GO:2000144)2.28786853
169membrane depolarization (GO:0051899)2.27428194
170regulation of translational termination (GO:0006449)2.27112539
171negative regulation of fibroblast apoptotic process (GO:2000270)2.26183114
172protein localization to chromosome, centromeric region (GO:0071459)2.25651768
173retrograde transport, vesicle recycling within Golgi (GO:0000301)2.25356317
174embryonic process involved in female pregnancy (GO:0060136)2.24926112
175protein deubiquitination (GO:0016579)2.24259949
176inner ear receptor cell development (GO:0060119)2.23914066
177regulation of glial cell proliferation (GO:0060251)2.23772377
178regulation of mRNA 3-end processing (GO:0031440)2.23659059
179histone H4 acetylation (GO:0043967)2.23048386
180negative regulation of neurotransmitter transport (GO:0051589)2.22689792
181regulation of Rap GTPase activity (GO:0032317)2.22189014
182signal complex assembly (GO:0007172)2.21482649
183regulation of cAMP-dependent protein kinase activity (GO:2000479)2.20780902
184peptidyl-tyrosine autophosphorylation (GO:0038083)2.20513521
185SMAD protein complex assembly (GO:0007183)2.16722731
186prepulse inhibition (GO:0060134)2.16693610

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.65289660
2EZH2_22144423_ChIP-Seq_EOC_Human3.01680255
3SMAD_19615063_ChIP-ChIP_OVARY_Human2.99008486
4KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.76144999
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.65795983
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.62300095
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.57249368
8TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.38845217
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.38615089
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.30822417
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.12766068
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.05717911
13IGF1R_20145208_ChIP-Seq_DFB_Human2.04089516
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.87612714
15SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.84988085
16AR_21572438_ChIP-Seq_LNCaP_Human1.84378982
17STAT6_21828071_ChIP-Seq_BEAS2B_Human1.84051686
18REST_21632747_ChIP-Seq_MESCs_Mouse1.83312449
19WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.83056386
20JARID2_20064375_ChIP-Seq_MESCs_Mouse1.82545473
21NOTCH1_21737748_ChIP-Seq_TLL_Human1.77819716
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.75193589
23WT1_19549856_ChIP-ChIP_CCG9911_Human1.74922690
24MYC_22102868_ChIP-Seq_BL_Human1.74475965
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72304846
26ZNF217_24962896_ChIP-Seq_MCF-7_Human1.72130580
27TP53_16413492_ChIP-PET_HCT116_Human1.71937485
28* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.70973220
29ZNF274_21170338_ChIP-Seq_K562_Hela1.68170930
30SCL_19346495_ChIP-Seq_HPC-7_Human1.67505208
31KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.66944939
32KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.66944939
33KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.66944939
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.66591753
35GBX2_23144817_ChIP-Seq_PC3_Human1.64402487
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62563644
37SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.62430425
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59728528
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.59655343
40MYB_26560356_Chip-Seq_TH2_Human1.59476026
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55874300
42SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.54125883
43STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.53078195
44PKCTHETA_26484144_Chip-Seq_BREAST_Human1.52201004
45KDM2B_26808549_Chip-Seq_DND41_Human1.50523352
46SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.49214560
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.48922386
48MTF2_20144788_ChIP-Seq_MESCs_Mouse1.47311897
49KDM2B_26808549_Chip-Seq_K562_Human1.46238448
50MYB_26560356_Chip-Seq_TH1_Human1.45687206
51SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45064748
52RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.44622187
53ZFP281_27345836_Chip-Seq_ESCs_Mouse1.43565180
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42930237
55RNF2_27304074_Chip-Seq_ESCs_Mouse1.42850387
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.40881436
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40424826
58DROSHA_22980978_ChIP-Seq_HELA_Human1.40416545
59EGR1_19374776_ChIP-ChIP_THP-1_Human1.39348619
60MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.39280091
61RNF2_18974828_ChIP-Seq_MESCs_Mouse1.38241026
62EZH2_18974828_ChIP-Seq_MESCs_Mouse1.38241026
63SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.38160674
64TCF4_18268006_ChIP-ChIP_LS174T_Human1.38131966
65* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37692942
66TAF15_26573619_Chip-Seq_HEK293_Human1.37329155
67RUNX_20019798_ChIP-Seq_JUKART_Human1.37206076
68MYB_21317192_ChIP-Seq_ERMYB_Mouse1.36842895
69TCF7_22412390_ChIP-Seq_EML_Mouse1.36720955
70GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36637150
71* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35839917
72* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35399353
73STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.34552657
74* SMAD4_21799915_ChIP-Seq_A2780_Human1.32403102
75PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.32069082
76GATA1_22025678_ChIP-Seq_K562_Human1.32021861
77SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.28699030
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27032194
79ZNF263_19887448_ChIP-Seq_K562_Human1.26516428
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26272403
81FUS_26573619_Chip-Seq_HEK293_Human1.25349543
82NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24996991
83SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.24345137
84AHR_22903824_ChIP-Seq_MCF-7_Human1.23682726
85KDM2B_26808549_Chip-Seq_JURKAT_Human1.22794204
86* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.22641856
87SOX2_21211035_ChIP-Seq_LN229_Gbm1.22327910
88FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.20633324
89PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20540916
90* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19825522
91Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.18657791
92* E2F1_21310950_ChIP-Seq_MCF-7_Human1.17939744
93KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17494057
94DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.16982895
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16770801
96ARNT_22903824_ChIP-Seq_MCF-7_Human1.16067964
97RXR_22108803_ChIP-Seq_LS180_Human1.16024543
98FOXO3_23340844_ChIP-Seq_DLD1_Human1.15876639
99VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15198972
100* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14948501
101PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14594392
102P300_19829295_ChIP-Seq_ESCs_Human1.13480369
103* IRF8_27001747_Chip-Seq_BMDM_Mouse1.12915180
104REST_18959480_ChIP-ChIP_MESCs_Mouse1.11411020
105* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11392777
106SMAD3_21741376_ChIP-Seq_EPCs_Human1.11170436
107SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.09990613
108* RING1B_27294783_Chip-Seq_NPCs_Mouse1.09578413
109POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08950566
110* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08670093
111FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.08161171
112CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.08047533
113FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07467572
114TCF4_23295773_ChIP-Seq_U87_Human1.06218395
115EZH2_27304074_Chip-Seq_ESCs_Mouse1.06216193
116STAT3_23295773_ChIP-Seq_U87_Human1.05672999
117POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05598536
118ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05462801
119CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05095321
120WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04796639
121SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04670788
122FLI1_27457419_Chip-Seq_LIVER_Mouse1.04479355
123SMAD3_21741376_ChIP-Seq_HESCs_Human1.04415501
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03619000
125TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03619000
126PIAS1_25552417_ChIP-Seq_VCAP_Human1.03482368
127YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03106490
128* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.02456551
129CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02404375
130* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01506474
131AR_19668381_ChIP-Seq_PC3_Human1.01411923
132SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00658201
133* PU_27001747_Chip-Seq_BMDM_Mouse1.00523416
134CHD1_26751641_Chip-Seq_LNCaP_Human0.99823071
135FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.98592724
136ER_23166858_ChIP-Seq_MCF-7_Human0.98358753
137SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.98312279
138JARID2_20075857_ChIP-Seq_MESCs_Mouse0.97876740
139TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97596951
140ELK1_19687146_ChIP-ChIP_HELA_Human0.96859861
141ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96851441
142STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95294357
143GATA3_27048872_Chip-Seq_THYMUS_Human0.94828679
144AR_25329375_ChIP-Seq_VCAP_Human0.94135659
145SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92978303
146TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92928601
147TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92712762
148PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.92596870
149EWS_26573619_Chip-Seq_HEK293_Human0.92246718
150TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92089981
151* FLI1_21867929_ChIP-Seq_TH2_Mouse0.91752534
152SUZ12_27294783_Chip-Seq_ESCs_Mouse0.91065595
153TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90643559
154CIITA_25753668_ChIP-Seq_RAJI_Human0.88228413
155NANOG_18555785_Chip-Seq_ESCs_Mouse0.87677934
156RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.87524592
157CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.86984449
158* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86315897

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.75303625
2MP0003880_abnormal_central_pattern4.21407608
3MP0003635_abnormal_synaptic_transmissio3.54356926
4MP0002396_abnormal_hematopoietic_system3.18825738
5MP0004270_analgesia2.98884250
6MP0002063_abnormal_learning/memory/cond2.81096733
7MP0009745_abnormal_behavioral_response2.68585300
8MP0008057_abnormal_DNA_replication2.60581589
9MP0002822_catalepsy2.60158539
10MP0002064_seizures2.59046879
11MP0009046_muscle_twitch2.55365858
12MP0010234_abnormal_vibrissa_follicle2.49135343
13MP0002009_preneoplasia2.47469924
14MP0003763_abnormal_thymus_physiology2.36151793
15MP0001440_abnormal_grooming_behavior2.33675327
16MP0002572_abnormal_emotion/affect_behav2.32338812
17MP0002877_abnormal_melanocyte_morpholog2.31339596
18MP0000569_abnormal_digit_pigmentation2.16874518
19MP0005076_abnormal_cell_differentiation1.98727476
20MP0003303_peritoneal_inflammation1.93940913
21MP0001968_abnormal_touch/_nociception1.93114982
22MP0001501_abnormal_sleep_pattern1.88060719
23MP0001486_abnormal_startle_reflex1.85141295
24MP0005623_abnormal_meninges_morphology1.84350260
25MP0004264_abnormal_extraembryonic_tissu1.81956223
26MP0002272_abnormal_nervous_system1.78484818
27MP0010352_gastrointestinal_tract_polyps1.73911300
28MP0001188_hyperpigmentation1.73419486
29MP0003890_abnormal_embryonic-extraembry1.72929882
30MP0000465_gastrointestinal_hemorrhage1.68472613
31MP0005423_abnormal_somatic_nervous1.62971924
32MP0004510_myositis1.61972005
33MP0003221_abnormal_cardiomyocyte_apopto1.61505967
34MP0003045_fibrosis1.61098305
35MP0003077_abnormal_cell_cycle1.57006181
36MP0000778_abnormal_nervous_system1.56734110
37MP0002734_abnormal_mechanical_nocicepti1.55812194
38MP0003123_paternal_imprinting1.54481718
39MP0004811_abnormal_neuron_physiology1.53584442
40MP0000383_abnormal_hair_follicle1.52814299
41MP0003787_abnormal_imprinting1.49717078
42MP0008961_abnormal_basal_metabolism1.48758165
43MP0010094_abnormal_chromosome_stability1.43350585
44MP0002796_impaired_skin_barrier1.43181452
45MP0004742_abnormal_vestibular_system1.42995633
46MP0000703_abnormal_thymus_morphology1.42698951
47MP0002088_abnormal_embryonic_growth/wei1.41964191
48MP0010307_abnormal_tumor_latency1.41485606
49MP0004233_abnormal_muscle_weight1.41352541
50MP0005409_darkened_coat_color1.40706806
51MP0003984_embryonic_growth_retardation1.39887318
52MP0004185_abnormal_adipocyte_glucose1.38865689
53MP0003329_amyloid_beta_deposits1.35523761
54MP0008569_lethality_at_weaning1.35204215
55MP0004957_abnormal_blastocyst_morpholog1.34693110
56MP0001672_abnormal_embryogenesis/_devel1.33781418
57MP0005380_embryogenesis_phenotype1.33781418
58MP0001919_abnormal_reproductive_system1.32380258
59MP0002733_abnormal_thermal_nociception1.32290472
60MP0000350_abnormal_cell_proliferation1.31824994
61MP0002398_abnormal_bone_marrow1.28004448
62MP0002067_abnormal_sensory_capabilities1.26224774
63MP0001730_embryonic_growth_arrest1.23643960
64MP0003567_abnormal_fetal_cardiomyocyte1.23579540
65MP0003633_abnormal_nervous_system1.23130128
66MP0004197_abnormal_fetal_growth/weight/1.22997215
67MP0002166_altered_tumor_susceptibility1.22394632
68MP0001970_abnormal_pain_threshold1.22276909
69* MP0003111_abnormal_nucleus_morphology1.18226850
70MP0004924_abnormal_behavior1.17941019
71MP0005386_behavior/neurological_phenoty1.17941019
72MP0003300_gastrointestinal_ulcer1.17335745
73MP0001191_abnormal_skin_condition1.15005612
74MP0001986_abnormal_taste_sensitivity1.14852774
75MP0002736_abnormal_nociception_after1.14187725
76MP0002184_abnormal_innervation1.13350288
77MP0000537_abnormal_urethra_morphology1.12781712
78MP0009780_abnormal_chondrocyte_physiolo1.12491717
79MP0002066_abnormal_motor_capabilities/c1.08154072
80MP0003656_abnormal_erythrocyte_physiolo1.07890835
81MP0003115_abnormal_respiratory_system1.05247435
82MP0000013_abnormal_adipose_tissue1.04382524
83MP0004885_abnormal_endolymph1.04180111
84MP0008770_decreased_survivor_rate1.03623623
85MP0004484_altered_response_of1.03436103
86MP0000955_abnormal_spinal_cord1.02639263
87MP0000428_abnormal_craniofacial_morphol1.02556800
88MP0002557_abnormal_social/conspecific_i1.02472369
89MP0003091_abnormal_cell_migration1.01430987
90MP0002722_abnormal_immune_system1.00696267
91MP0001216_abnormal_epidermal_layer1.00659635
92MP0008995_early_reproductive_senescence1.00385617
93MP0003941_abnormal_skin_development0.99964412
94MP0001697_abnormal_embryo_size0.98377112
95MP0003693_abnormal_embryo_hatching0.98107154
96MP0005248_abnormal_Harderian_gland0.98103264
97MP0008007_abnormal_cellular_replicative0.98058332
98MP0004858_abnormal_nervous_system0.97811186
99MP0005257_abnormal_intraocular_pressure0.97666066
100MP0002098_abnormal_vibrissa_morphology0.97138073
101MP0002152_abnormal_brain_morphology0.97130040
102MP0000920_abnormal_myelination0.96590458
103MP0000689_abnormal_spleen_morphology0.96426254
104MP0000516_abnormal_urinary_system0.95880959
105MP0005367_renal/urinary_system_phenotyp0.95880959
106MP0000377_abnormal_hair_follicle0.95278379
107MP0003631_nervous_system_phenotype0.94736519
108MP0008877_abnormal_DNA_methylation0.93943632
109MP0001849_ear_inflammation0.92867922
110MP0005621_abnormal_cell_physiology0.91780850
111MP0002735_abnormal_chemical_nociception0.91758244
112MP0001800_abnormal_humoral_immune0.91109820
113MP0000747_muscle_weakness0.91066623
114MP0002882_abnormal_neuron_morphology0.90997899
115MP0000490_abnormal_crypts_of0.90760025
116MP0000751_myopathy0.89637546
117MP0005501_abnormal_skin_physiology0.89605278
118MP0003943_abnormal_hepatobiliary_system0.89274945
119MP0008058_abnormal_DNA_repair0.89077674
120MP0001915_intracranial_hemorrhage0.88170375
121MP0010678_abnormal_skin_adnexa0.87625905
122MP0009672_abnormal_birth_weight0.86034203
123MP0001340_abnormal_eyelid_morphology0.86012147
124* MP0002080_prenatal_lethality0.85555279
125MP0000604_amyloidosis0.84179443
126MP0000716_abnormal_immune_system0.83832214
127MP0003121_genomic_imprinting0.83766026
128MP0002006_tumorigenesis0.83590815
129MP0003119_abnormal_digestive_system0.82741251
130MP0003935_abnormal_craniofacial_develop0.82080408
131MP0009278_abnormal_bone_marrow0.81051453
132* MP0002925_abnormal_cardiovascular_devel0.81020320
133MP0002085_abnormal_embryonic_tissue0.80994202
134MP0003183_abnormal_peptide_metabolism0.79846576
135MP0009931_abnormal_skin_appearance0.78978748
136MP0003879_abnormal_hair_cell0.78912363
137MP0000427_abnormal_hair_cycle0.78774794
138MP0008874_decreased_physiological_sensi0.78602747
139MP0005310_abnormal_salivary_gland0.76513066
140MP0003075_altered_response_to0.74955536
141MP0000613_abnormal_salivary_gland0.74813257
142MP0005384_cellular_phenotype0.74211441
143MP0003634_abnormal_glial_cell0.73997119
144MP0003861_abnormal_nervous_system0.73281592
145MP0002420_abnormal_adaptive_immunity0.73080593
146MP0003937_abnormal_limbs/digits/tail_de0.72598527
147MP0004145_abnormal_muscle_electrophysio0.72429702
148MP0003453_abnormal_keratinocyte_physiol0.72373646
149MP0002019_abnormal_tumor_incidence0.72103864
150MP0001819_abnormal_immune_cell0.71970713
151MP0001299_abnormal_eye_distance/0.71734490
152MP0004947_skin_inflammation0.71617819
153MP0009703_decreased_birth_body0.70981454
154MP0002429_abnormal_blood_cell0.69515775
155MP0004808_abnormal_hematopoietic_stem0.67281497
156MP0001293_anophthalmia0.67086561
157MP0001784_abnormal_fluid_regulation0.65179640
158MP0003690_abnormal_glial_cell0.63841313
159MP0003828_pulmonary_edema0.63496824
160MP0000733_abnormal_muscle_development0.62980153
161MP0003632_abnormal_nervous_system0.61715038
162MP0002254_reproductive_system_inflammat0.60602481
163MP0002092_abnormal_eye_morphology0.59218131
164MP0010769_abnormal_survival0.58321984
165* MP0002086_abnormal_extraembryonic_tissu0.57474775
166MP0001851_eye_inflammation0.57095579
167MP0003705_abnormal_hypodermis_morpholog0.56418053
168MP0010768_mortality/aging0.55766310
169MP0002084_abnormal_developmental_patter0.55535214
170MP0005166_decreased_susceptibility_to0.54330066
171MP0001177_atelectasis0.54127095

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.05947912
2Focal seizures (HP:0007359)3.70180288
3Curly hair (HP:0002212)3.67960723
4Visual hallucinations (HP:0002367)3.62159764
5Atonic seizures (HP:0010819)3.56436456
6Absence seizures (HP:0002121)3.38833995
7Insidious onset (HP:0003587)3.25641358
8Termporal pattern (HP:0011008)3.25641358
9Papillary thyroid carcinoma (HP:0002895)3.08084870
10Genetic anticipation (HP:0003743)3.06271377
11Dialeptic seizures (HP:0011146)3.03995846
12Inappropriate behavior (HP:0000719)2.98106196
13Cerebral inclusion bodies (HP:0100314)2.92949306
14Febrile seizures (HP:0002373)2.87453474
15Broad-based gait (HP:0002136)2.76648326
16Epileptic encephalopathy (HP:0200134)2.75705928
17Subacute progressive viral hepatitis (HP:0006572)2.66904662
18Truncal ataxia (HP:0002078)2.64458427
19Progressive cerebellar ataxia (HP:0002073)2.60466788
20Drooling (HP:0002307)2.58015794
21Excessive salivation (HP:0003781)2.58015794
22Amyotrophic lateral sclerosis (HP:0007354)2.56964915
23Acute myeloid leukemia (HP:0004808)2.54652242
24Supranuclear gaze palsy (HP:0000605)2.54434596
25Abnormality of the corticospinal tract (HP:0002492)2.53809181
26Capillary hemangiomas (HP:0005306)2.53633874
27Transitional cell carcinoma of the bladder (HP:0006740)2.51460003
28Volvulus (HP:0002580)2.50310466
29Absent frontal sinuses (HP:0002688)2.48803047
30Action tremor (HP:0002345)2.48731160
31Facial hemangioma (HP:0000329)2.48180808
32Bladder carcinoma (HP:0002862)2.44954193
33Bladder neoplasm (HP:0009725)2.44954193
34Impaired smooth pursuit (HP:0007772)2.42820321
35Deep philtrum (HP:0002002)2.40503973
36T lymphocytopenia (HP:0005403)2.40056942
37Abnormal hair whorl (HP:0010721)2.38495772
38Truncal obesity (HP:0001956)2.37974717
39Cubitus valgus (HP:0002967)2.37631040
40Embryonal renal neoplasm (HP:0011794)2.36088963
41Urinary urgency (HP:0000012)2.35981771
42Impaired social interactions (HP:0000735)2.35746926
43Abnormal social behavior (HP:0012433)2.35746926
44Abnormality of the lower motor neuron (HP:0002366)2.35473424
45Disinhibition (HP:0000734)2.35086750
46Urinary bladder sphincter dysfunction (HP:0002839)2.33267699
47Thyroid carcinoma (HP:0002890)2.32853924
48Mutism (HP:0002300)2.31608767
49Absent eyebrow (HP:0002223)2.31405116
50Apathy (HP:0000741)2.31339263
51Aqueductal stenosis (HP:0002410)2.30443434
52Viral hepatitis (HP:0006562)2.28367575
53Relative macrocephaly (HP:0004482)2.28289761
54Neurofibrillary tangles (HP:0002185)2.27076890
55Dysmetric saccades (HP:0000641)2.24792976
56Neoplasm of the tracheobronchial system (HP:0100552)2.23509881
57Nephroblastoma (Wilms tumor) (HP:0002667)2.23370139
58Germ cell neoplasia (HP:0100728)2.21547182
59Hyperventilation (HP:0002883)2.19462468
60Thickened helices (HP:0000391)2.19141126
61Abnormality of binocular vision (HP:0011514)2.18969707
62Diplopia (HP:0000651)2.18969707
63Poor eye contact (HP:0000817)2.18475783
64Cystic hygroma (HP:0000476)2.17648320
65Neoplasm of the adrenal cortex (HP:0100641)2.15229734
66Protruding tongue (HP:0010808)2.15177522
67Abnormality of T cell number (HP:0011839)2.14929831
68Amblyopia (HP:0000646)2.13575682
69Biliary tract neoplasm (HP:0100574)2.13424612
70Macroorchidism (HP:0000053)2.13419957
71Cerebral aneurysm (HP:0004944)2.11489973
72Medulloblastoma (HP:0002885)2.08416944
73Abnormality of ocular smooth pursuit (HP:0000617)2.06773997
74Keratoconjunctivitis sicca (HP:0001097)2.05233162
75Abnormality of the columella (HP:0009929)2.05204034
76Abnormality of the astrocytes (HP:0100707)2.04214248
77Astrocytoma (HP:0009592)2.04214248
78Neonatal hypoglycemia (HP:0001998)2.03246088
79Myokymia (HP:0002411)2.02917670
80Generalized tonic-clonic seizures (HP:0002069)2.02765919
81Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.02442950
82Gastrointestinal carcinoma (HP:0002672)2.00342584
83Malignant gastrointestinal tract tumors (HP:0006749)2.00342584
84Impaired vibration sensation in the lower limbs (HP:0002166)2.00101241
85Vertebral arch anomaly (HP:0008438)1.99196062
86Subaortic stenosis (HP:0001682)1.99182125
87Abnormality of the left ventricular outflow tract (HP:0011103)1.99182125
88Abnormality of the lumbar spine (HP:0100712)1.98602638
89Deep palmar crease (HP:0006191)1.97562876
90Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.97233206
91Sandal gap (HP:0001852)1.97214650
92Dysmetria (HP:0001310)1.96356013
93Retrobulbar optic neuritis (HP:0100654)1.95096606
94Optic neuritis (HP:0100653)1.95096606
95Widely spaced teeth (HP:0000687)1.95087579
96Hepatoblastoma (HP:0002884)1.95072796
97Persistence of primary teeth (HP:0006335)1.93782847
98Abnormality of chromosome segregation (HP:0002916)1.92801201
99Uterine leiomyosarcoma (HP:0002891)1.92668555
100Leiomyosarcoma (HP:0100243)1.92668555
101Shoulder girdle muscle weakness (HP:0003547)1.92433434
102Diminished motivation (HP:0000745)1.91482326
103Papilledema (HP:0001085)1.91188837
104Acute lymphatic leukemia (HP:0006721)1.90790179
105Tapered finger (HP:0001182)1.90100725
106Prominent nose (HP:0000448)1.90083572
107Degeneration of the lateral corticospinal tracts (HP:0002314)1.89554730
108Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.89554730
109Lower limb amyotrophy (HP:0007210)1.87972407
110Sparse lateral eyebrow (HP:0005338)1.87081037
111Anteriorly placed anus (HP:0001545)1.85913554
112Stomach cancer (HP:0012126)1.84364301
113Ulnar bowing (HP:0003031)1.84361192
114Intention tremor (HP:0002080)1.84115859
115Alveolar cell carcinoma (HP:0006519)1.81821174
116Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.81392075
117Pointed chin (HP:0000307)1.81210506
118Stereotypic behavior (HP:0000733)1.80319105
119Pelvic girdle muscle weakness (HP:0003749)1.79549076
120Lip pit (HP:0100267)1.79092884
121Deviation of the thumb (HP:0009603)1.78595789
122Keratoconjunctivitis (HP:0001096)1.77922248
123Broad alveolar ridges (HP:0000187)1.77583630
124Abnormality of the nasal septum (HP:0000419)1.76742061
125Ependymoma (HP:0002888)1.75099281
126Absent speech (HP:0001344)1.75031699
127Anhidrosis (HP:0000970)1.74958691
128Hemiparesis (HP:0001269)1.74594154
129Septate vagina (HP:0001153)1.74165646
130Skull defect (HP:0001362)1.74111096
131Gaze-evoked nystagmus (HP:0000640)1.73146937
132Recurrent viral infections (HP:0004429)1.72775436
133Abnormal foot bone ossification (HP:0010675)1.72558245
134Heterotopia (HP:0002282)1.71949991
135Abnormality of the hip-girdle musculature (HP:0001445)1.71920148
136Abnormality of the musculature of the pelvis (HP:0001469)1.71920148
137Abnormality of the labia minora (HP:0012880)1.71736649
138Abnormal delayed hypersensitivity skin test (HP:0002963)1.71729340
139Slow saccadic eye movements (HP:0000514)1.71628100
140Cafe-au-lait spot (HP:0000957)1.71273204
141Genu recurvatum (HP:0002816)1.71104763
142* Spinal cord lesions (HP:0100561)1.70749043
143* Syringomyelia (HP:0003396)1.70749043
144Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.70169743
145Abnormality of oral frenula (HP:0000190)1.70121832
146Lower limb asymmetry (HP:0100559)1.69969014
147Abnormality of the epiphyses of the hand (HP:0005924)1.69664466
148Abnormality of the fingertips (HP:0001211)1.69634873
149Prostate neoplasm (HP:0100787)1.69051287
150Dysdiadochokinesis (HP:0002075)1.68988523
151Long eyelashes (HP:0000527)1.68453696
152Cutis marmorata (HP:0000965)1.67978671
153Abnormality of nail color (HP:0100643)1.67859318
154Ankyloglossia (HP:0010296)1.67779810
155Proximal placement of thumb (HP:0009623)1.66886385
156Neoplasm of the small intestine (HP:0100833)1.66634999
157Open mouth (HP:0000194)1.66260350
158Cortical dysplasia (HP:0002539)1.64881452
159Coarse hair (HP:0002208)1.62581329
160Agnosia (HP:0010524)1.62321796
161Depression (HP:0000716)1.61373176
162Increased number of teeth (HP:0011069)1.60382042
1632-3 toe syndactyly (HP:0004691)1.60239921
164Hematochezia (HP:0002573)1.59595732
165Narrow palate (HP:0000189)1.59462997
166Short chin (HP:0000331)1.59241246
167Abnormality of salivation (HP:0100755)1.57694015
168Achilles tendon contracture (HP:0001771)1.57643894
169Breast carcinoma (HP:0003002)1.57102141
170Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.56910035
171Overlapping toe (HP:0001845)1.56440890
172Short 1st metacarpal (HP:0010034)1.55457774
173Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.55457774
174Epileptiform EEG discharges (HP:0011182)1.54633687
175Increased density of long bones (HP:0006392)1.51648907
176Shallow orbits (HP:0000586)1.51344206
177Basal cell carcinoma (HP:0002671)1.50471287
178Bowel diverticulosis (HP:0005222)1.49638360
179Lower limb muscle weakness (HP:0007340)1.49517507

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.25669675
2KSR23.15938570
3MAP3K93.15808697
4NTRK33.09867650
5IRAK22.84966147
6EPHA42.80805771
7MAP3K42.70034806
8PNCK2.66163628
9MST1R2.56791078
10MAP3K22.48789446
11CDK122.38580569
12MKNK22.37703704
13PRPF4B2.23606139
14MAP3K142.23304091
15IRAK12.16567313
16ERBB32.12410497
17YES12.12020119
18PIK3CA2.06458223
19SIK21.97763534
20MAP3K61.96134569
21TAOK31.95140998
22MKNK11.90956303
23RPS6KA41.87697587
24DAPK21.82801528
25CAMK1D1.77664846
26EIF2AK31.74349335
27SCYL21.67529451
28TYRO31.63430048
29KSR11.61189049
30MAP3K101.60217268
31STK38L1.52243459
32MARK11.50266736
33LATS11.45056021
34RET1.43842636
35SGK21.41932312
36PAK61.40953456
37MAP3K131.39321186
38AKT31.35613643
39STK241.30015134
40RIPK11.27778335
41MAP2K41.27574863
42ALK1.27453765
43TAF11.26334381
44NTRK11.26144939
45CASK1.25441209
46NLK1.24188383
47IKBKE1.22348927
48DYRK31.21312223
49WNK11.20730620
50MARK31.19908420
51RAF11.17637066
52TXK1.16332901
53NTRK21.15046864
54CAMKK21.14527011
55MINK11.13810620
56BCR1.08716831
57SIK31.06741717
58FGFR21.06052417
59IRAK41.05476267
60FGR1.04501267
61DAPK11.03556932
62CDK51.02312498
63STK111.01912695
64TRPM71.00590993
65MET0.98826549
66PDGFRB0.98430120
67LATS20.97519147
68RPS6KB20.97417876
69GRK50.95934405
70RPS6KB10.95889561
71GRK60.95611582
72SRPK10.94293335
73EPHA30.90649926
74BRSK20.89506644
75STK30.84301199
76JAK10.84014131
77PDK10.83750207
78DDR20.82257205
79STK100.82179681
80BRD40.77796539
81TNIK0.77266813
82FES0.76212570
83EIF2AK20.75475857
84PLK20.75123455
85MATK0.74122444
86PDGFRA0.73576486
87PKN20.72467144
88SGK2230.71597600
89SGK4940.71597600
90UHMK10.71567605
91CHEK10.71419824
92CAMKK10.70977846
93PRKD30.70617339
94NEK60.69819186
95BMX0.67891582
96CAMK40.67804940
97SGK10.66315049
98CDK40.65506520
99TEC0.63987528
100MAP2K70.63888465
101MAPK100.63495099
102JAK20.63469963
103DMPK0.63072649
104ARAF0.60304001
105CAMK1G0.60041733
106HIPK20.59931948
107MARK20.58708693
108BTK0.58264224
109PDPK10.58258591
110BMPR20.57415096
111CSK0.56933195
112EGFR0.55907663
113ATM0.55651887
114MAP2K10.55354259
115TNK20.55199395
116PTK2B0.55019370
117ATR0.53656610
118CDK90.53346604
119CLK10.53297648
120NEK90.53157299
121CSNK1A1L0.51879501
122ZAK0.51287010
123SGK30.50965905
124DYRK1A0.50615060
125RPS6KA30.49297622
126MTOR0.48435787
127ITK0.47496243
128PASK0.47208672
129TYK20.46248120
130CDC70.45871806
131CSNK1D0.43902684
132TSSK60.43785855
133MAPK70.43570086
134GSK3A0.43562866
135MAP3K10.43550730
136PRKCQ0.43252743
137CDK60.43069710
138MELK0.42981861
139PKN10.42722111
140MAP3K50.42681080
141FYN0.42553964
142CAMK2A0.41512002
143CDK30.40201723
144HCK0.39093521
145PIM10.38737516
146PAK30.37836689
147PIK3CG0.37665511
148EEF2K0.37658907
149CHUK0.37620093
150WNK30.37516834
151MAPK80.35942015
152FRK0.35760859
153INSR0.34330637
154DYRK1B0.34330623
155MAPK130.34090424
156MAP4K10.33577358
157MOS0.32841220
158MAPK120.31833267
159FGFR30.30921522
160PRKCH0.30853064

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.52970784
2Long-term potentiation_Homo sapiens_hsa047202.50594741
3Dorso-ventral axis formation_Homo sapiens_hsa043202.02005611
4Acute myeloid leukemia_Homo sapiens_hsa052211.85981778
5Amphetamine addiction_Homo sapiens_hsa050311.84548282
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.76806234
7Glutamatergic synapse_Homo sapiens_hsa047241.76684101
8Circadian entrainment_Homo sapiens_hsa047131.73992667
9Salivary secretion_Homo sapiens_hsa049701.70102540
10Morphine addiction_Homo sapiens_hsa050321.65816649
11GABAergic synapse_Homo sapiens_hsa047271.58192333
12Hepatitis B_Homo sapiens_hsa051611.58047449
13Prolactin signaling pathway_Homo sapiens_hsa049171.55472644
14Renin secretion_Homo sapiens_hsa049241.53324442
15Prostate cancer_Homo sapiens_hsa052151.50742257
16Long-term depression_Homo sapiens_hsa047301.50407331
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.50317155
18Phosphatidylinositol signaling system_Homo sapiens_hsa040701.46068592
19Oxytocin signaling pathway_Homo sapiens_hsa049211.45975806
20Thyroid cancer_Homo sapiens_hsa052161.45858057
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.43049075
22Viral carcinogenesis_Homo sapiens_hsa052031.42188224
23Dopaminergic synapse_Homo sapiens_hsa047281.40605211
24Olfactory transduction_Homo sapiens_hsa047401.40387849
25Synaptic vesicle cycle_Homo sapiens_hsa047211.40277780
26GnRH signaling pathway_Homo sapiens_hsa049121.38127976
27Type II diabetes mellitus_Homo sapiens_hsa049301.36160554
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35793393
29Estrogen signaling pathway_Homo sapiens_hsa049151.34919059
30Glioma_Homo sapiens_hsa052141.32743140
31Gastric acid secretion_Homo sapiens_hsa049711.31480890
32mTOR signaling pathway_Homo sapiens_hsa041501.31451183
33Transcriptional misregulation in cancer_Homo sapiens_hsa052021.31233610
34ErbB signaling pathway_Homo sapiens_hsa040121.29169702
35mRNA surveillance pathway_Homo sapiens_hsa030151.28489591
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.28392985
37Small cell lung cancer_Homo sapiens_hsa052221.26538323
38Measles_Homo sapiens_hsa051621.26209037
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.25469608
40B cell receptor signaling pathway_Homo sapiens_hsa046621.25210966
41NOD-like receptor signaling pathway_Homo sapiens_hsa046211.22899521
42Nitrogen metabolism_Homo sapiens_hsa009101.21770059
43Cholinergic synapse_Homo sapiens_hsa047251.18998380
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.18721904
45Cell cycle_Homo sapiens_hsa041101.17954315
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.17085699
47Renal cell carcinoma_Homo sapiens_hsa052111.15530130
48VEGF signaling pathway_Homo sapiens_hsa043701.15114937
49Herpes simplex infection_Homo sapiens_hsa051681.13051474
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11820934
51Hepatitis C_Homo sapiens_hsa051601.10843147
52cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10506332
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09283819
54Calcium signaling pathway_Homo sapiens_hsa040201.09090904
55TNF signaling pathway_Homo sapiens_hsa046681.08847368
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.08753386
57Toll-like receptor signaling pathway_Homo sapiens_hsa046201.08517970
58Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08174149
59Oocyte meiosis_Homo sapiens_hsa041141.07327884
60cAMP signaling pathway_Homo sapiens_hsa040241.06530227
61MAPK signaling pathway_Homo sapiens_hsa040101.05005760
62Axon guidance_Homo sapiens_hsa043601.04650768
63T cell receptor signaling pathway_Homo sapiens_hsa046601.04646324
64Choline metabolism in cancer_Homo sapiens_hsa052311.02251260
65Neurotrophin signaling pathway_Homo sapiens_hsa047221.02093026
66Colorectal cancer_Homo sapiens_hsa052100.99240397
67Systemic lupus erythematosus_Homo sapiens_hsa053220.98976234
68Inositol phosphate metabolism_Homo sapiens_hsa005620.98581647
69Taste transduction_Homo sapiens_hsa047420.97975746
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.97855055
71Gap junction_Homo sapiens_hsa045400.97250727
72Serotonergic synapse_Homo sapiens_hsa047260.97034120
73Non-small cell lung cancer_Homo sapiens_hsa052230.95876026
74Insulin secretion_Homo sapiens_hsa049110.95865654
75Influenza A_Homo sapiens_hsa051640.93237163
76Cocaine addiction_Homo sapiens_hsa050300.92607305
77Apoptosis_Homo sapiens_hsa042100.91108081
78Melanogenesis_Homo sapiens_hsa049160.91032131
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90312875
80Osteoclast differentiation_Homo sapiens_hsa043800.89465759
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88927809
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88335583
83Non-homologous end-joining_Homo sapiens_hsa034500.86034458
84Selenocompound metabolism_Homo sapiens_hsa004500.84983450
85Spliceosome_Homo sapiens_hsa030400.84504871
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.84372998
87TGF-beta signaling pathway_Homo sapiens_hsa043500.84100538
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.81945550
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.81667540
90Basal transcription factors_Homo sapiens_hsa030220.81120799
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80174177
92RNA transport_Homo sapiens_hsa030130.79281673
93Chronic myeloid leukemia_Homo sapiens_hsa052200.78997222
94HTLV-I infection_Homo sapiens_hsa051660.78507416
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78421596
96Lysine degradation_Homo sapiens_hsa003100.78177765
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77946309
98Leishmaniasis_Homo sapiens_hsa051400.76825370
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.76631799
100Platelet activation_Homo sapiens_hsa046110.76561369
101Endometrial cancer_Homo sapiens_hsa052130.76481379
102Circadian rhythm_Homo sapiens_hsa047100.75860621
103Melanoma_Homo sapiens_hsa052180.75735697
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74821642
105Pathways in cancer_Homo sapiens_hsa052000.74748836
106Proteoglycans in cancer_Homo sapiens_hsa052050.74015160
107Bladder cancer_Homo sapiens_hsa052190.72332493
108Legionellosis_Homo sapiens_hsa051340.71614101
109Notch signaling pathway_Homo sapiens_hsa043300.70849172
110MicroRNAs in cancer_Homo sapiens_hsa052060.69522540
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69241897
112p53 signaling pathway_Homo sapiens_hsa041150.69139565
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69020910
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67953286
115AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67650984
116Rap1 signaling pathway_Homo sapiens_hsa040150.66302113
117Chemokine signaling pathway_Homo sapiens_hsa040620.65826395
118Glucagon signaling pathway_Homo sapiens_hsa049220.65313552
119FoxO signaling pathway_Homo sapiens_hsa040680.63921647
120Fatty acid biosynthesis_Homo sapiens_hsa000610.63898468
121Epstein-Barr virus infection_Homo sapiens_hsa051690.63484361
122Adherens junction_Homo sapiens_hsa045200.63313226
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.63080032
124RNA degradation_Homo sapiens_hsa030180.63011280
125Mineral absorption_Homo sapiens_hsa049780.62857645
126Pancreatic cancer_Homo sapiens_hsa052120.62606665
127Endocytosis_Homo sapiens_hsa041440.62415130
128Tuberculosis_Homo sapiens_hsa051520.61568731
129Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61103149
130African trypanosomiasis_Homo sapiens_hsa051430.60923351
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60731027
132Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60441805
133AMPK signaling pathway_Homo sapiens_hsa041520.60096573
134Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58943629
135Insulin resistance_Homo sapiens_hsa049310.58941970
136Wnt signaling pathway_Homo sapiens_hsa043100.58937967
137Leukocyte transendothelial migration_Homo sapiens_hsa046700.58592435
138Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58381658
139Insulin signaling pathway_Homo sapiens_hsa049100.57919559
140Prion diseases_Homo sapiens_hsa050200.56793472
141Focal adhesion_Homo sapiens_hsa045100.56388377
142Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55812475
143Toxoplasmosis_Homo sapiens_hsa051450.55458456
144Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55392787
145Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54805540
146Ras signaling pathway_Homo sapiens_hsa040140.54703070
147Amoebiasis_Homo sapiens_hsa051460.54269316
148Dilated cardiomyopathy_Homo sapiens_hsa054140.54147786
149Alcoholism_Homo sapiens_hsa050340.53962114
150Collecting duct acid secretion_Homo sapiens_hsa049660.53605097
151HIF-1 signaling pathway_Homo sapiens_hsa040660.53413250

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »