LENEP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The ocular lens is a tissue of epithelial origin and devoid of blood vessels and nerves. Cells of the lens epithelium are responsible for the growth and maintenance of the lens through mitosis, protein synthesis, and active transport of ions and metabolites across the lens capsule. Lens epithelial protein is expressed exclusively in lens epithelial cells and may play a role in cell differentiation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to ATP (GO:0071318)9.81540173
2negative regulation of cell aging (GO:0090344)9.75707387
3DNA strand renaturation (GO:0000733)9.25793435
4GDP-mannose metabolic process (GO:0019673)8.77273000
5adenosine receptor signaling pathway (GO:0001973)7.88412626
6meiotic chromosome segregation (GO:0045132)7.63056743
7peptidyl-glutamic acid carboxylation (GO:0017187)7.50363763
8protein carboxylation (GO:0018214)7.50363763
9regulation of synapse structural plasticity (GO:0051823)7.49968353
10response to muscle activity (GO:0014850)7.29953756
11visual perception (GO:0007601)7.08001360
12mitotic cell cycle arrest (GO:0071850)7.05980729
13lens morphogenesis in camera-type eye (GO:0002089)7.05177630
14G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)7.03341345
15sensory perception of light stimulus (GO:0050953)7.02612386
16purinergic nucleotide receptor signaling pathway (GO:0035590)6.71029247
17rRNA methylation (GO:0031167)6.48131736
18regulation of protein sumoylation (GO:0033233)5.92428430
19sensory perception of taste (GO:0050909)5.86687407
20regulation of cytokine production involved in inflammatory response (GO:1900015)5.85852889
21negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)5.70876337
22detection of light stimulus involved in sensory perception (GO:0050962)5.70745134
23detection of light stimulus involved in visual perception (GO:0050908)5.70745134
24transepithelial transport (GO:0070633)5.67770603
25rRNA modification (GO:0000154)5.63472681
26positive regulation of protein kinase C signaling (GO:0090037)5.49661971
27purine ribonucleotide transport (GO:0015868)5.48447043
28camera-type eye development (GO:0043010)5.43094992
29adenine nucleotide transport (GO:0051503)5.41092377
30response to ATP (GO:0033198)5.23481241
31muscle cell cellular homeostasis (GO:0046716)5.13231825
32negative regulation of homotypic cell-cell adhesion (GO:0034111)5.08883702
33behavioral response to nicotine (GO:0035095)5.06910682
34estrogen biosynthetic process (GO:0006703)4.97495892
35granulocyte differentiation (GO:0030851)4.82277252
36protein refolding (GO:0042026)4.81975516
37purinergic receptor signaling pathway (GO:0035587)4.81124337
38urinary tract smooth muscle contraction (GO:0014848)4.77684466
39positive regulation of heat generation (GO:0031652)4.72403047
40cytolysis (GO:0019835)4.71654485
41eye development (GO:0001654)4.58224561
42regulation of phospholipid biosynthetic process (GO:0071071)4.55220236
43nucleoside transmembrane transport (GO:1901642)4.53353490
44regulation of platelet aggregation (GO:0090330)4.52960811
45G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.49663836
46nucleotide-sugar biosynthetic process (GO:0009226)4.43083655
47nucleotide transmembrane transport (GO:1901679)4.39408621
48regulation of cell aging (GO:0090342)4.37602938
49purine nucleotide transport (GO:0015865)4.29042610
50melanin biosynthetic process (GO:0042438)4.28568059
51UV protection (GO:0009650)4.17918300
52G-protein coupled purinergic receptor signaling pathway (GO:0035588)4.06366943
53presynaptic membrane assembly (GO:0097105)4.05393197
54peristalsis (GO:0030432)4.03396331
55cellular anion homeostasis (GO:0030002)4.01358044
56bile acid and bile salt transport (GO:0015721)4.00724028
57sulfur amino acid catabolic process (GO:0000098)4.00627752
58neuromuscular synaptic transmission (GO:0007274)3.95613708
59regulation of protein kinase A signaling (GO:0010738)3.92075825
60sensory perception (GO:0007600)3.91024905
61myofibril assembly (GO:0030239)3.90974904
62sex determination (GO:0007530)3.86114741
63phosphatidylglycerol biosynthetic process (GO:0006655)3.85557041
64grooming behavior (GO:0007625)3.81672559
65melanin metabolic process (GO:0006582)3.81128468
66sphingomyelin metabolic process (GO:0006684)3.79005110
67cellular response to osmotic stress (GO:0071470)3.74190727
68phosphate ion homeostasis (GO:0055062)3.73873470
69trivalent inorganic anion homeostasis (GO:0072506)3.73873470
70cardiolipin metabolic process (GO:0032048)3.70814494
71semaphorin-plexin signaling pathway (GO:0071526)3.65523466
72sensory organ development (GO:0007423)3.64923175
73protein import into peroxisome matrix (GO:0016558)3.63678285
74histone H3-K9 demethylation (GO:0033169)3.62250420
753-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.60922704
76purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.60922704
77negative regulation of interleukin-8 production (GO:0032717)3.60876183
78cilium or flagellum-dependent cell motility (GO:0001539)3.56400903
79folic acid metabolic process (GO:0046655)3.55359758
80iron coordination entity transport (GO:1901678)3.53110233
81regulation of heat generation (GO:0031650)3.50571830
82secondary metabolite biosynthetic process (GO:0044550)3.50371692
83nucleoside bisphosphate biosynthetic process (GO:0033866)3.50300059
84purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.50300059
85ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.50300059
86presynaptic membrane organization (GO:0097090)3.47388149
87postsynaptic membrane organization (GO:0001941)3.46798004
88heme transport (GO:0015886)3.46081244
89mitochondrion distribution (GO:0048311)3.45918853
90mannose metabolic process (GO:0006013)3.44707051
91DNA replication checkpoint (GO:0000076)3.44524153
92regulation of nuclear cell cycle DNA replication (GO:0033262)3.44022742
93DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.43967839
94positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)3.43095342
95sphingosine metabolic process (GO:0006670)3.42953187
96positive regulation of megakaryocyte differentiation (GO:0045654)3.40368446
97histone phosphorylation (GO:0016572)3.33692183
98nucleoside transport (GO:0015858)3.31817234
99protein insertion into membrane (GO:0051205)3.30142592
100peptidyl-glutamic acid modification (GO:0018200)3.30039505
101endocytic recycling (GO:0032456)3.28925496
102phosphate ion transmembrane transport (GO:0035435)3.28026339
103type B pancreatic cell proliferation (GO:0044342)3.25328700
104response to salt stress (GO:0009651)3.21056247
105diol metabolic process (GO:0034311)3.20121410
106ribosomal small subunit biogenesis (GO:0042274)3.18562420
107regulation of homotypic cell-cell adhesion (GO:0034110)3.17457392
108axon ensheathment in central nervous system (GO:0032291)3.17228407
109central nervous system myelination (GO:0022010)3.17228407
110activation of adenylate cyclase activity (GO:0007190)3.16655723
111neuron cell-cell adhesion (GO:0007158)3.15307344
112positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.12597570
113regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)3.11621489
114tRNA modification (GO:0006400)3.11013288
115sialylation (GO:0097503)3.09709309
116regulation of myoblast differentiation (GO:0045661)3.09056306
117glutamate receptor signaling pathway (GO:0007215)3.06736020
118dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.04532024
119negative regulation of neurotransmitter transport (GO:0051589)3.01999276
120cerebellar granule cell differentiation (GO:0021707)3.00935090
121positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.00677271
122DNA damage response, signal transduction resulting in transcription (GO:0042772)3.00026760
123lens development in camera-type eye (GO:0002088)26.1844601
124folic acid transport (GO:0015884)2.99675410
125regulation of skeletal muscle fiber development (GO:0048742)2.97621157
126regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.96162690
127positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.96133094
128phosphatidylethanolamine biosynthetic process (GO:0006646)2.95357692
129forebrain neuron development (GO:0021884)2.94586781
130protein localization to synapse (GO:0035418)2.93914305
131muscle fiber development (GO:0048747)2.93874773
132gonadal mesoderm development (GO:0007506)2.93579611
133insulin-like growth factor receptor signaling pathway (GO:0048009)2.86672183
134cell migration in hindbrain (GO:0021535)2.82562840
135proline biosynthetic process (GO:0006561)2.82458447
136neuronal action potential propagation (GO:0019227)2.82247555
137regulation of meiosis (GO:0040020)2.81954052
138base-excision repair, AP site formation (GO:0006285)2.81771886
139positive regulation of dendritic spine morphogenesis (GO:0061003)2.81290819
140viral transcription (GO:0019083)2.80798114
141cyclic nucleotide catabolic process (GO:0009214)2.78927211
142cAMP catabolic process (GO:0006198)2.76875034
143amino acid import (GO:0043090)2.74099868
144facial nerve structural organization (GO:0021612)2.66927225
145translational termination (GO:0006415)2.65015303
146viral protein processing (GO:0019082)2.63596021
147synaptic transmission, glutamatergic (GO:0035249)2.63025656
148response to pheromone (GO:0019236)2.61316150
149positive regulation of calcium ion transport into cytosol (GO:0010524)2.58351814
150axonal fasciculation (GO:0007413)2.58276717
151L-amino acid import (GO:0043092)2.58194602
152positive regulation of synapse assembly (GO:0051965)2.57529394
153negative regulation of neurotransmitter secretion (GO:0046929)2.54863711
154cardiovascular system development (GO:0072358)2.54637820
155positive regulation of dendritic spine development (GO:0060999)2.51695678
156ionotropic glutamate receptor signaling pathway (GO:0035235)2.50235703
157adult walking behavior (GO:0007628)2.49520234
158protein homotrimerization (GO:0070207)2.49490657
159mating behavior (GO:0007617)2.48723502
160regulation of glutamate receptor signaling pathway (GO:1900449)2.45557147
161positive regulation of synaptic transmission, GABAergic (GO:0032230)2.45500048
162negative regulation of axon extension involved in axon guidance (GO:0048843)2.43807977
163head development (GO:0060322)2.42322988
164sarcomere organization (GO:0045214)2.42264773
165cerebral cortex radially oriented cell migration (GO:0021799)2.39443698
166dendrite morphogenesis (GO:0048813)2.36993265
167negative regulation of platelet activation (GO:0010544)2.36797602
168negative regulation of axon guidance (GO:1902668)2.34264910
169negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.33929617
170neuron recognition (GO:0008038)2.33833915
171regulation of non-canonical Wnt signaling pathway (GO:2000050)2.33540750
172regulation of skeletal muscle tissue development (GO:0048641)2.29600944
173dopaminergic neuron differentiation (GO:0071542)2.29153297
174regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.28747747
175cotranslational protein targeting to membrane (GO:0006613)2.28162155
176central nervous system neuron development (GO:0021954)2.25011859
177SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.24948808
178protein targeting to ER (GO:0045047)2.24761812
179telencephalon development (GO:0021537)2.22493066
180cranial nerve structural organization (GO:0021604)2.21800685
181regulation of axon extension involved in axon guidance (GO:0048841)2.21704242
182metanephric nephron tubule development (GO:0072234)2.21062502
183metanephric tubule development (GO:0072170)2.21062502
184regulation of axon guidance (GO:1902667)2.18129755
185neuron-neuron synaptic transmission (GO:0007270)2.17677786
186cellular response to calcium ion (GO:0071277)2.17080384
187protein localization to endoplasmic reticulum (GO:0070972)2.16974396
188positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.16933055
189astrocyte differentiation (GO:0048708)2.16506091
190establishment of protein localization to endoplasmic reticulum (GO:0072599)2.14431335
191neuronal stem cell maintenance (GO:0097150)2.14029600
192cellular response to pH (GO:0071467)2.13571056
193regulation of respiratory system process (GO:0044065)2.11841054
194C-terminal protein amino acid modification (GO:0018410)2.11724207
195positive regulation of potassium ion transmembrane transport (GO:1901381)2.10585325
196neurotransmitter-gated ion channel clustering (GO:0072578)2.10580584
197lens fiber cell development (GO:0070307)18.3263335
198lens fiber cell differentiation (GO:0070306)14.8957371
199regulation of skeletal muscle contraction (GO:0014819)10.0339551

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.62184805
2GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse5.03267935
3VDR_21846776_ChIP-Seq_THP-1_Human4.52674708
4STAT6_21828071_ChIP-Seq_BEAS2B_Human4.08175549
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.94300432
6IKZF1_21737484_ChIP-ChIP_HCT116_Human3.51113549
7TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse3.28303908
8P68_20966046_ChIP-Seq_HELA_Human3.23050401
9XRN2_22483619_ChIP-Seq_HELA_Human3.06364593
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse3.05867174
11JARID2_20064375_ChIP-Seq_MESCs_Mouse3.05716871
12CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human3.00853662
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.98956274
14* LXR_22292898_ChIP-Seq_THP-1_Human2.86625530
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.69410660
16GBX2_23144817_ChIP-Seq_PC3_Human2.68909373
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.68867117
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.62739103
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.61913672
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.61182189
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.56992152
22* MAF_26560356_Chip-Seq_TH2_Human2.53821261
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.52627523
24ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.46744916
25* E2F1_20622854_ChIP-Seq_HELA_Human2.45539200
26CBX2_27304074_Chip-Seq_ESCs_Mouse2.41490380
27RNF2_18974828_ChIP-Seq_MESCs_Mouse2.38789446
28EZH2_18974828_ChIP-Seq_MESCs_Mouse2.38789446
29DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.37292270
30MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human2.34981079
31ERG_21242973_ChIP-ChIP_JURKAT_Human2.34961516
32PCGF2_27294783_Chip-Seq_NPCs_Mouse2.32334377
33JARID2_20075857_ChIP-Seq_MESCs_Mouse2.29675534
34* BCOR_27268052_Chip-Seq_Bcells_Human2.28760728
35IGF1R_20145208_ChIP-Seq_DFB_Human2.27329389
36RARG_19884340_ChIP-ChIP_MEFs_Mouse2.25677135
37RACK7_27058665_Chip-Seq_MCF-7_Human2.23438839
38CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.23136047
39* BCL6_27268052_Chip-Seq_Bcells_Human2.18727084
40* PHF8_20622854_ChIP-Seq_HELA_Human2.17156348
41VDR_24763502_ChIP-Seq_THP-1_Human2.14936004
42DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.10396367
43MAF_26560356_Chip-Seq_TH1_Human2.09985018
44RARB_24833708_ChIP-Seq_LIVER_Mouse2.08977250
45* CTCF_27219007_Chip-Seq_ERYTHROID_Human2.06118364
46MTF2_20144788_ChIP-Seq_MESCs_Mouse2.04332985
47TET1_21451524_ChIP-Seq_MESCs_Mouse2.03497367
48CREB1_26743006_Chip-Seq_LNCaP-abl_Human2.03193557
49RXRA_24833708_ChIP-Seq_LIVER_Mouse2.01110142
50RARA_24833708_ChIP-Seq_LIVER_Mouse1.98715524
51FOXP1_21924763_ChIP-Seq_HESCs_Human1.95302069
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.93366171
53SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.92703685
54RNF2_27304074_Chip-Seq_ESCs_Mouse1.89849729
55SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.85545392
56ZNF274_21170338_ChIP-Seq_K562_Hela1.85069512
57SMC4_20622854_ChIP-Seq_HELA_Human1.84011237
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.83438518
59FUS_26573619_Chip-Seq_HEK293_Human1.83427353
60* CTCF_21964334_Chip-Seq_Bcells_Human1.82264748
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.79620476
62GATA1_22025678_ChIP-Seq_K562_Human1.77916744
63SUZ12_27294783_Chip-Seq_ESCs_Mouse1.75810991
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.75485134
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73700671
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.72681313
67TP63_19390658_ChIP-ChIP_HaCaT_Human1.72163441
68SA1_27219007_Chip-Seq_ERYTHROID_Human1.68718203
69CREB1_26743006_Chip-Seq_LNCaP_Human1.68444934
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.68251279
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68075559
72SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67505780
73SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.65889550
74CTCF_21964334_ChIP-Seq_BJAB-B_Human1.65433095
75* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.65192608
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.64743980
77CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.62850561
78CTCF_20526341_ChIP-Seq_ESCs_Human1.62786453
79UTX_26944678_Chip-Seq_JUKART_Human1.60201151
80* ELF1_20517297_ChIP-Seq_JURKAT_Human1.59138929
81JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.58934125
82MYC_22102868_ChIP-Seq_BL_Human1.58771074
83RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.57325020
84KDM2B_26808549_Chip-Seq_DND41_Human1.56083688
85* YY1_22570637_ChIP-Seq_MALME-3M_Human1.54536588
86KDM2B_26808549_Chip-Seq_SUP-B15_Human1.54418926
87ERA_21632823_ChIP-Seq_H3396_Human1.51706526
88CIITA_25753668_ChIP-Seq_RAJI_Human1.49307792
89BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.48803917
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.47850299
91* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.46149510
92CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44170701
93RUNX1_27457419_Chip-Seq_LIVER_Mouse1.42664634
94SRY_22984422_ChIP-ChIP_TESTIS_Rat1.42096742
95EZH2_27294783_Chip-Seq_NPCs_Mouse1.39985776
96CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39371477
97VDR_22108803_ChIP-Seq_LS180_Human1.38418231
98* TP53_22127205_ChIP-Seq_IMR90_Human1.38263904
99* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.34267334
100ETS1_21867929_ChIP-Seq_TH2_Mouse1.34242280
101P53_22387025_ChIP-Seq_ESCs_Mouse1.33392305
102DROSHA_22980978_ChIP-Seq_HELA_Human1.33357299
103TCF7_22412390_ChIP-Seq_EML_Mouse1.32728463
104* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.32322813
105SMAD1_18555785_Chip-Seq_ESCs_Mouse1.28476568
106EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.27864992
107REST_21632747_ChIP-Seq_MESCs_Mouse1.27833481
108* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.27476674
109E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27336500
110PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26775162
111FOXM1_23109430_ChIP-Seq_U2OS_Human1.26459195
112SMAD3_21741376_ChIP-Seq_EPCs_Human1.25955159
113LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25286913
114* SA1_27219007_Chip-Seq_Bcells_Human1.24390189
115NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24332295
116FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.24141372
117NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.24102148
118ELK3_25401928_ChIP-Seq_HUVEC_Human1.22747351
119DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22561461
120DCP1A_22483619_ChIP-Seq_HELA_Human1.22410906
121RING1B_27294783_Chip-Seq_ESCs_Mouse1.22162666
122E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22047356
123PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21853365
124BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20522488
125SOX2_18555785_Chip-Seq_ESCs_Mouse1.19514232
126P53_21459846_ChIP-Seq_SAOS-2_Human1.19150831
127P300_18555785_Chip-Seq_ESCs_Mouse1.18987921
128ATF3_27146783_Chip-Seq_COLON_Human1.18959111
129P300_19829295_ChIP-Seq_ESCs_Human1.18949402
130CTCF_18555785_Chip-Seq_ESCs_Mouse1.18738517
131JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.18094075
132MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17980907
133GABP_19822575_ChIP-Seq_HepG2_Human1.17630600
134CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.17537370
135REST_18959480_ChIP-ChIP_MESCs_Mouse1.17473588
136VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17200410
137P300_27268052_Chip-Seq_Bcells_Human1.15891372
138ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.14468418
139PU1_27457419_Chip-Seq_LIVER_Mouse1.13952475
140UBF1/2_26484160_Chip-Seq_HMECs_Human1.13831896
141PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13643905
142UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12934597
143CMYC_18555785_Chip-Seq_ESCs_Mouse1.12207732
144CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10286058
145CTCF_26484167_Chip-Seq_Bcells_Mouse1.09945983
146TP53_20018659_ChIP-ChIP_R1E_Mouse1.09409730
147ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09054467
148TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08505163
149TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.08142140
150* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07966630
151PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07455614
152NCOR1_26117541_ChIP-Seq_K562_Human1.07410700
153RING1B_27294783_Chip-Seq_NPCs_Mouse1.07155900
154* NANOG_20526341_ChIP-Seq_ESCs_Human1.06642316
155TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06631741
156SMC3_22415368_ChIP-Seq_MEFs_Mouse1.06629356
157SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06253146
158CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05228673
159SALL1_21062744_ChIP-ChIP_HESCs_Human1.04771075
160KLF4_18555785_Chip-Seq_ESCs_Mouse1.04489704
161OCT4_19829295_ChIP-Seq_ESCs_Human1.03667491
162OCT4_20526341_ChIP-Seq_ESCs_Human1.03579518
163ZFX_18555785_Chip-Seq_ESCs_Mouse1.03577894
164TAF2_19829295_ChIP-Seq_ESCs_Human1.02257784
165TP63_22573176_ChIP-Seq_HFKS_Human1.01490108
166SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01308461
167PPARA_22158963_ChIP-Seq_LIVER_Mouse1.01276102
168E2F1_18555785_Chip-Seq_ESCs_Mouse1.00840123
169HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.99390963
170STAT3_18555785_Chip-Seq_ESCs_Mouse0.98058648
171MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97951864
172RUNX1_27514584_Chip-Seq_MCF-7_Human0.97623782
173OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96364939
174TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94465734
175PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94009088
176AR_25329375_ChIP-Seq_VCAP_Human0.93860445
177CRX_20693478_ChIP-Seq_RETINA_Mouse0.93489633
178NANOG_16153702_ChIP-ChIP_HESCs_Human0.93283679
179HTT_18923047_ChIP-ChIP_STHdh_Human0.91412935
180PIAS1_25552417_ChIP-Seq_VCAP_Human0.90926807
181SOX2_16153702_ChIP-ChIP_HESCs_Human0.88365047
182EGR1_19032775_ChIP-ChIP_M12_Human0.87949645
183P53_22127205_ChIP-Seq_FIBROBLAST_Human0.87607119
184ZNF217_24962896_ChIP-Seq_MCF-7_Human0.86301489
185NANOG_18555785_Chip-Seq_ESCs_Mouse0.84294233
186* CTCF_27219007_Chip-Seq_Bcells_Human0.83918435
187NR3C1_23031785_ChIP-Seq_PC12_Mouse0.83581715
188RUNX2_22187159_ChIP-Seq_PCA_Human0.82683003
189OCT4_21477851_ChIP-Seq_ESCs_Mouse0.82420635
190SMAD4_21799915_ChIP-Seq_A2780_Human0.81941498
191TCF4_23295773_ChIP-Seq_U87_Human0.81740085
192* CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.81714804
193TP53_18474530_ChIP-ChIP_U2OS_Human0.81530213
194SMAD3_21741376_ChIP-Seq_ESCs_Human0.81002707
195TAF15_26573619_Chip-Seq_HEK293_Human0.79966135
196CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.79257577

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005193_abnormal_anterior_eye6.51515054
2MP0001986_abnormal_taste_sensitivity6.45681796
3MP0005423_abnormal_somatic_nervous5.93993716
4MP0005253_abnormal_eye_physiology4.08739262
5MP0003136_yellow_coat_color3.95306278
6MP0006292_abnormal_olfactory_placode3.90788530
7MP0005083_abnormal_biliary_tract3.17372450
8MP0001286_abnormal_eye_development2.95787111
9MP0005197_abnormal_uvea_morphology2.87420329
10MP0003880_abnormal_central_pattern2.81640886
11MP0008875_abnormal_xenobiotic_pharmacok2.78240837
12MP0003941_abnormal_skin_development2.68227534
13MP0002092_abnormal_eye_morphology2.63908563
14MP0000749_muscle_degeneration2.62155324
15MP0005391_vision/eye_phenotype2.53742702
16MP0000751_myopathy2.53110911
17MP0001756_abnormal_urination2.49146214
18MP0002638_abnormal_pupillary_reflex2.29280887
19MP0001661_extended_life_span2.20513974
20MP0005171_absent_coat_pigmentation2.20215041
21MP0001905_abnormal_dopamine_level2.18789814
22MP0004859_abnormal_synaptic_plasticity2.09136023
23MP0002160_abnormal_reproductive_system2.02272788
24MP0002697_abnormal_eye_size10.2131947
25MP0002736_abnormal_nociception_after1.90453442
26MP0001968_abnormal_touch/_nociception1.86933826
27MP0001346_abnormal_lacrimal_gland1.85488823
28MP0000750_abnormal_muscle_regeneration1.78279780
29MP0004381_abnormal_hair_follicle1.77548598
30MP0009379_abnormal_foot_pigmentation1.73026502
31MP0000538_abnormal_urinary_bladder1.71571497
32MP0002735_abnormal_chemical_nociception1.70982586
33MP0003635_abnormal_synaptic_transmissio1.69874858
34MP0002090_abnormal_vision1.64441476
35MP0004130_abnormal_muscle_cell1.60404664
36MP0003453_abnormal_keratinocyte_physiol1.59842304
37MP0005174_abnormal_tail_pigmentation1.55210320
38MP0004142_abnormal_muscle_tone1.54269597
39MP0009745_abnormal_behavioral_response1.46988323
40MP0002064_seizures1.44809077
41MP0000372_irregular_coat_pigmentation1.39756295
42MP0003111_abnormal_nucleus_morphology1.39331356
43MP0006276_abnormal_autonomic_nervous1.37026189
44MP0000049_abnormal_middle_ear1.36608522
45MP0005332_abnormal_amino_acid1.36172257
46MP0003806_abnormal_nucleotide_metabolis1.31197426
47MP0004270_analgesia1.29040465
48MP0002272_abnormal_nervous_system1.28418564
49MP0000013_abnormal_adipose_tissue1.27983409
50MP0005365_abnormal_bile_salt1.27809962
51MP0002234_abnormal_pharynx_morphology1.27566335
52MP0005084_abnormal_gallbladder_morpholo1.27148466
53MP0003705_abnormal_hypodermis_morpholog1.26450984
54MP0005551_abnormal_eye_electrophysiolog1.23770496
55MP0001486_abnormal_startle_reflex1.21876019
56MP0002067_abnormal_sensory_capabilities1.20400267
57MP0005501_abnormal_skin_physiology1.18375081
58MP0005410_abnormal_fertilization1.18291031
59MP0000747_muscle_weakness1.17705587
60MP0000778_abnormal_nervous_system1.17325779
61MP0005379_endocrine/exocrine_gland_phen1.16220418
62MP0002063_abnormal_learning/memory/cond1.15127103
63MP0002734_abnormal_mechanical_nocicepti1.11920895
64MP0002572_abnormal_emotion/affect_behav1.11910403
65MP0001919_abnormal_reproductive_system1.09362322
66MP0001502_abnormal_circadian_rhythm1.07678988
67MP0005409_darkened_coat_color1.07514769
68MP0005195_abnormal_posterior_eye1.06764528
69MP0002177_abnormal_outer_ear1.04423297
70MP0001485_abnormal_pinna_reflex1.04419868
71MP0003879_abnormal_hair_cell1.03662773
72MP0000470_abnormal_stomach_morphology0.98764353
73MP0004272_abnormal_basement_membrane0.97171450
74MP0000003_abnormal_adipose_tissue0.96958306
75MP0009046_muscle_twitch0.96147853
76MP0001299_abnormal_eye_distance/0.96004964
77MP0000015_abnormal_ear_pigmentation0.95285198
78MP0005584_abnormal_enzyme/coenzyme_acti0.94970055
79MP0003693_abnormal_embryo_hatching0.94343552
80MP0002557_abnormal_social/conspecific_i0.92474708
81MP0004019_abnormal_vitamin_homeostasis0.91702851
82MP0001188_hyperpigmentation0.91474261
83MP0002909_abnormal_adrenal_gland0.91008819
84MP0010386_abnormal_urinary_bladder0.90577106
85MP0000920_abnormal_myelination0.88752560
86MP0005377_hearing/vestibular/ear_phenot0.86502849
87MP0003878_abnormal_ear_physiology0.86502849
88MP0002184_abnormal_innervation0.86332257
89MP0004858_abnormal_nervous_system0.86153903
90MP0008260_abnormal_autophagy0.84380743
91MP0005389_reproductive_system_phenotype0.82967802
92MP0002733_abnormal_thermal_nociception0.82439908
93MP0001529_abnormal_vocalization0.82236843
94MP0003183_abnormal_peptide_metabolism0.81133110
95MP0001873_stomach_inflammation0.80127030
96MP0004133_heterotaxia0.78505605
97MP0005645_abnormal_hypothalamus_physiol0.78082323
98MP0001970_abnormal_pain_threshold0.76872858
99MP0002882_abnormal_neuron_morphology0.76849001
100MP0002163_abnormal_gland_morphology0.75972491
101MP0004957_abnormal_blastocyst_morpholog0.75913091
102MP0001958_emphysema0.74575303
103MP0005076_abnormal_cell_differentiation0.73923816
104MP0003077_abnormal_cell_cycle0.73396563
105MP0001440_abnormal_grooming_behavior0.72035941
106MP0000367_abnormal_coat/_hair0.70585713
107MP0003137_abnormal_impulse_conducting0.70057227
108MP0002254_reproductive_system_inflammat0.69820937
109MP0001340_abnormal_eyelid_morphology0.69693837
110MP0002277_abnormal_respiratory_mucosa0.68630053
111MP0005646_abnormal_pituitary_gland0.68462330
112MP0009643_abnormal_urine_homeostasis0.68071294
113MP0004742_abnormal_vestibular_system0.68059821
114MP0002095_abnormal_skin_pigmentation0.68027080
115MP0008569_lethality_at_weaning0.67553251
116MP0000631_abnormal_neuroendocrine_gland0.67526638
117MP0003938_abnormal_ear_development0.67207766
118MP0005058_abnormal_lysosome_morphology0.66975564
119MP0004215_abnormal_myocardial_fiber0.66604199
120MP0001963_abnormal_hearing_physiology0.66255671
121MP0000026_abnormal_inner_ear0.65677039
122MP0000358_abnormal_cell_content/0.64557136
123MP0009931_abnormal_skin_appearance0.64019029
124MP0002089_abnormal_postnatal_growth/wei0.62970274
125MP0003123_paternal_imprinting0.62042532
126MP0005257_abnormal_intraocular_pressure0.61975036
127MP0002066_abnormal_motor_capabilities/c0.61853791
128MP0005220_abnormal_exocrine_pancreas0.61648514
129MP0002928_abnormal_bile_duct0.60549124
130MP0001324_abnormal_eye_pigmentation0.59862505
131MP0002249_abnormal_larynx_morphology0.59010384
132MP0004185_abnormal_adipocyte_glucose0.57533708
133MP0010771_integument_phenotype0.57264098
134MP0004924_abnormal_behavior0.56927886
135MP0005386_behavior/neurological_phenoty0.56927886
136MP0004147_increased_porphyrin_level0.56756177
137MP0000955_abnormal_spinal_cord0.56752714
138MP0002752_abnormal_somatic_nervous0.56411983
139MP0001348_abnormal_lacrimal_gland0.56362374
140MP0002152_abnormal_brain_morphology0.56087817
141MP0004197_abnormal_fetal_growth/weight/0.54846134
142MP0002019_abnormal_tumor_incidence0.54592921
143MP0004043_abnormal_pH_regulation0.54372398
144MP0002938_white_spotting0.54054965
145MP0002108_abnormal_muscle_morphology0.53582651
146MP0003122_maternal_imprinting0.53483569
147MP0003448_altered_tumor_morphology0.52374067
148MP0004885_abnormal_endolymph0.52131476
149MP0002136_abnormal_kidney_physiology0.51144122
150MP0002210_abnormal_sex_determination0.50746925
151MP0005330_cardiomyopathy0.49828165
152MP0002876_abnormal_thyroid_physiology0.49820650
153MP0010094_abnormal_chromosome_stability0.49689278
154MP0008770_decreased_survivor_rate0.49623485
155MP0002229_neurodegeneration0.49585590
156MP0003303_peritoneal_inflammation0.48059595
157MP0002751_abnormal_autonomic_nervous0.47868717
158MP0001765_abnormal_ion_homeostasis0.47290770
159MP0001664_abnormal_digestion0.47123343
160MP0001191_abnormal_skin_condition0.47001266
161MP0003315_abnormal_perineum_morphology0.44348738
162MP0003011_delayed_dark_adaptation0.43816582
163MP0005085_abnormal_gallbladder_physiolo0.42598931
164MP0002075_abnormal_coat/hair_pigmentati0.40976885
165MP0005375_adipose_tissue_phenotype0.40671753
166MP0002118_abnormal_lipid_homeostasis0.40629419
167MP0009840_abnormal_foam_cell0.36893308
168MP0004087_abnormal_muscle_fiber0.36405812
169MP0003632_abnormal_nervous_system0.35760595
170MP0003091_abnormal_cell_migration0.33460177
171MP0009384_cardiac_valve_regurgitation0.32402292
172MP0001784_abnormal_fluid_regulation0.32069239
173MP0003943_abnormal_hepatobiliary_system0.31255886
174MP0010769_abnormal_survival0.31185801
175MP0002933_joint_inflammation0.31072991

Predicted human phenotypes

RankGene SetZ-score
1Congenital cataract (HP:0000519)7.22882308
2Corneal dystrophy (HP:0001131)7.13577586
3Testicular atrophy (HP:0000029)6.84778149
4Amblyopia (HP:0000646)6.78555137
5Anterior segment dysgenesis (HP:0007700)5.90522075
6Dyschromatopsia (HP:0007641)5.80575015
7Rectovaginal fistula (HP:0000143)5.48873788
8Rectal fistula (HP:0100590)5.48873788
9Attenuation of retinal blood vessels (HP:0007843)5.48201300
10Intestinal fistula (HP:0100819)5.13691954
11Poikiloderma (HP:0001029)5.07325104
12Vaginal fistula (HP:0004320)4.97633783
13Thin bony cortex (HP:0002753)4.94055359
14Abnormality of the intrinsic pathway (HP:0010989)4.67773182
15Facial hemangioma (HP:0000329)4.64497826
16Annular pancreas (HP:0001734)4.57557726
17Mesangial abnormality (HP:0001966)4.40759682
18Congenital stationary night blindness (HP:0007642)4.31955601
19Facial diplegia (HP:0001349)4.30632895
20Ulnar bowing (HP:0003031)4.20902412
21Prolonged partial thromboplastin time (HP:0003645)4.18199479
22Joint hemorrhage (HP:0005261)4.10426597
23Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.05721850
24Turricephaly (HP:0000262)4.03553990
25Clumsiness (HP:0002312)4.01086189
26Polar cataract (HP:0010696)3.95642408
27Hemorrhage of the eye (HP:0011885)3.93799598
28Coronal craniosynostosis (HP:0004440)3.80881957
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.80722813
30Bony spicule pigmentary retinopathy (HP:0007737)3.79801013
31Increased hepatocellular lipid droplets (HP:0006565)3.77181057
32Choroideremia (HP:0001139)3.72439866
33Renal Fanconi syndrome (HP:0001994)3.65163655
34Lipid accumulation in hepatocytes (HP:0006561)3.58343607
35Squamous cell carcinoma (HP:0002860)3.54794857
36Delayed epiphyseal ossification (HP:0002663)3.54316471
37Microcornea (HP:0000482)3.52965824
38Anteriorly placed anus (HP:0001545)3.52469550
39Chorioretinal atrophy (HP:0000533)3.45906193
40Patellar aplasia (HP:0006443)3.39730319
41Short chin (HP:0000331)3.26780874
42Decreased electroretinogram (ERG) amplitude (HP:0000654)3.22337182
43Hypoalbuminemia (HP:0003073)3.17931905
44Abnormal albumin level (HP:0012116)3.17931905
45Decreased central vision (HP:0007663)3.13317124
46Aplasia/Hypoplasia of the patella (HP:0006498)3.12697434
47Atrioventricular block (HP:0001678)3.11000108
48Iris coloboma (HP:0000612)3.05535109
49Enlarged epiphyses (HP:0010580)3.01133027
50Abnormality of the costochondral junction (HP:0000919)3.00024175
51Nuclear cataract (HP:0100018)25.9052232
52Zonular cataract (HP:0010920)22.9777796
53Myotonia (HP:0002486)2.97857072
54Eosinophilia (HP:0001880)2.97772839
55Hypophosphatemic rickets (HP:0004912)2.94004958
56Congenital primary aphakia (HP:0007707)2.79723426
57Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.77024660
58Absent thumb (HP:0009777)2.76254621
59Capillary hemangiomas (HP:0005306)2.74930836
60Sclerocornea (HP:0000647)2.64123820
61Birth length less than 3rd percentile (HP:0003561)2.62895946
62Increased intramyocellular lipid droplets (HP:0012240)2.54531319
63Neonatal onset (HP:0003623)2.50102301
64Opacification of the corneal stroma (HP:0007759)2.49700072
65Premature graying of hair (HP:0002216)2.49173793
66Widely patent fontanelles and sutures (HP:0004492)2.48725081
67Increased muscle lipid content (HP:0009058)2.42001859
68Bowing of the arm (HP:0006488)2.41728985
69Bowed forearm bones (HP:0003956)2.41728985
70Joint stiffness (HP:0001387)2.39688410
71Granulocytopenia (HP:0001913)2.39656845
72Aplasia/Hypoplasia of the lens (HP:0008063)2.38797420
73Choanal stenosis (HP:0000452)2.38030667
74Abnormality of the anterior chamber (HP:0000593)2.36953481
75Abnormal epiphyseal ossification (HP:0010656)2.35234530
76Narrow nasal bridge (HP:0000446)2.33538788
77Abnormality of the common coagulation pathway (HP:0010990)2.31724968
78Exertional dyspnea (HP:0002875)2.31577216
79Flat occiput (HP:0005469)2.29534426
80Short humerus (HP:0005792)2.26884279
81Increased number of teeth (HP:0011069)2.26410105
82Abnormal urine phosphate concentration (HP:0012599)2.25463155
83Abnormality of renal resorption (HP:0011038)2.22292111
84Male infertility (HP:0003251)2.21596540
85Respiratory difficulties (HP:0002880)2.15195349
86Abnormality of eosinophils (HP:0001879)2.13486743
87Basal cell carcinoma (HP:0002671)2.10836804
88Type 2 muscle fiber atrophy (HP:0003554)2.06433133
89Aplasia/hypoplasia of the humerus (HP:0006507)2.03294003
90Reduced antithrombin III activity (HP:0001976)2.03259865
91Epiphyseal stippling (HP:0010655)2.01126064
92Pterygium (HP:0001059)2.00031520
93Aplasia/Hypoplasia of the macula (HP:0008059)1.99946769
94Abnormal drinking behavior (HP:0030082)1.97065184
95Polydipsia (HP:0001959)1.97065184
96Myopathic facies (HP:0002058)1.96807694
97Cystic hygroma (HP:0000476)1.94745818
98Absent radius (HP:0003974)1.94268466
99Fetal akinesia sequence (HP:0001989)1.91289324
100Muscle fiber atrophy (HP:0100295)1.91289050
101Fatigable weakness (HP:0003473)1.91159602
102Abnormality of the neuromuscular junction (HP:0003398)1.91159602
103Akinesia (HP:0002304)1.90628783
104Hypoplasia of the radius (HP:0002984)1.89944869
105Abnormality of the hepatic vasculature (HP:0006707)1.88264432
106Heart block (HP:0012722)1.88205251
107Cheilitis (HP:0100825)1.86981274
108Proximal amyotrophy (HP:0007126)1.82121432
109Aplasia/Hypoplasia affecting the retina (HP:0008061)1.80744159
110Aplasia of the musculature (HP:0100854)1.79622337
111Neonatal respiratory distress (HP:0002643)1.75587446
112Hypoplastic nipples (HP:0002557)1.74156498
113Focal motor seizures (HP:0011153)1.73214130
114Amniotic constriction ring (HP:0009775)1.72305465
115Abnormality of placental membranes (HP:0011409)1.72305465
116Scapular winging (HP:0003691)1.53533582
117Hypoplastic heart (HP:0001961)1.48001510
118Severe visual impairment (HP:0001141)1.47440623
119Posterior subcapsular cataract (HP:0007787)1.39464510
120Popliteal pterygium (HP:0009756)1.38916661
121Leukocytosis (HP:0001974)1.37197971
122Split foot (HP:0001839)1.35753355
123Hypothermia (HP:0002045)1.29127820
124Rib fusion (HP:0000902)1.20108600
125Difficulty walking (HP:0002355)1.08805208
126Symphalangism affecting the phalanges of the hand (HP:0009773)1.08085500
127Long clavicles (HP:0000890)1.03742322
128Chorioretinal coloboma (HP:0000567)1.02605968
129Hypoplasia of the fovea (HP:0007750)1.02418856
130Aplasia/Hypoplasia of the fovea (HP:0008060)1.02418856
131Aplasia/Hypoplasia of the nipples (HP:0006709)1.00319388
132Blue irides (HP:0000635)0.99010779
133Aplasia/Hypoplasia involving the musculature (HP:0001460)0.98765122
134Retinal dysplasia (HP:0007973)0.97756552
135Atelectasis (HP:0100750)0.96977489
136Decreased circulating renin level (HP:0003351)0.96885507
137Abnormality of the shoulder girdle musculature (HP:0001435)0.96232356
138Diminished movement (HP:0002374)0.95105150
139Myelomeningocele (HP:0002475)0.94637923
140Neoplasm of the heart (HP:0100544)0.91751383
141Congenital sensorineural hearing impairment (HP:0008527)0.91480463
142Abnormal number of incisors (HP:0011064)0.91421342
143Malignant hyperthermia (HP:0002047)0.91071436
144Aplasia/Hypoplasia affecting the fundus (HP:0008057)0.88739136
145Broad-based gait (HP:0002136)0.85421504
146Epileptic encephalopathy (HP:0200134)0.84519665
147Abnormality of the fovea (HP:0000493)0.84231778
148Microvesicular hepatic steatosis (HP:0001414)0.82568908
149Meningocele (HP:0002435)0.82555836
150Prolonged QT interval (HP:0001657)0.79998351
151Morphological abnormality of the inner ear (HP:0011390)0.79359498
152Humeroradial synostosis (HP:0003041)0.79237768
153Synostosis involving the elbow (HP:0003938)0.79237768
154Degeneration of the lateral corticospinal tracts (HP:0002314)0.78888882
155Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)0.78888882
156Abnormality of cochlea (HP:0000375)0.78707487
157Hyperventilation (HP:0002883)0.77105377
158Hemiparesis (HP:0001269)0.76318563
159Spastic gait (HP:0002064)0.76003177
160Fused cervical vertebrae (HP:0002949)0.73793162
161Submucous cleft hard palate (HP:0000176)0.72688408
162Type II lissencephaly (HP:0007260)0.72590370
163Limb dystonia (HP:0002451)0.72256957
164Nonprogressive disorder (HP:0003680)0.71983568
165Lymphangioma (HP:0100764)0.71797002
166Protruding tongue (HP:0010808)0.70616506
167Febrile seizures (HP:0002373)0.69146997
168Hepatocellular necrosis (HP:0001404)0.68737559
169Focal seizures (HP:0007359)0.68600258
170Hypoplastic pelvis (HP:0008839)0.68327751
171Supranuclear gaze palsy (HP:0000605)0.68112254
172Optic nerve hypoplasia (HP:0000609)0.67796327
173Hypoparathyroidism (HP:0000829)0.66235961
174Abnormality of dental color (HP:0011073)0.66129855
175Aplasia cutis congenita (HP:0001057)0.65633143
176Poor head control (HP:0002421)0.64979880
177Hypoplastic left heart (HP:0004383)0.64841219
178Vertebral clefting (HP:0008428)0.63059768
179Psychosis (HP:0000709)0.62902052
180Hyperkalemia (HP:0002153)0.62687692
181Poor suck (HP:0002033)0.62521346
182Sensory axonal neuropathy (HP:0003390)0.61968500
183Hyperactive renin-angiotensin system (HP:0000841)0.61960477
184Thin ribs (HP:0000883)0.61844689
185Progressive cerebellar ataxia (HP:0002073)0.61796379
186Abnormality of calcium-phosphate metabolism (HP:0100530)0.61447431

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK6.63694588
2INSRR4.97614768
3MAP2K64.31652504
4NTRK33.91712084
5BLK3.01609462
6STK392.55181328
7WNK42.26678987
8TESK22.25535435
9MAPK132.18185196
10CASK2.03899310
11MAPK1510.7327929
12SGK11.97210188
13MAP2K71.91906454
14GRK61.86929874
15MAP3K121.79987778
16SIK21.79769064
17PRPF4B1.73297822
18ACVR1B1.69534637
19FLT31.69172071
20PKN11.63349629
21ZAK1.61489080
22PRKD21.60460858
23SIK11.57339144
24IRAK41.54433909
25AKT31.52742029
26FES1.51593033
27TRIB31.50200715
28CDK191.47864172
29PRKG11.36800002
30ERN11.30856384
31CCNB11.30179257
32DYRK21.29372387
33SCYL21.28679967
34BMPR1B1.26239831
35IRAK21.23983861
36PDPK11.20196675
37EIF2AK31.17810545
38MUSK1.14971553
39STK101.09489186
40PRKD31.06642687
41MARK31.06478407
42ZAP701.06235106
43DAPK21.03315241
44MAP2K30.99543320
45CDK60.98404447
46WNK10.93178458
47CDK150.91886191
48YES10.90373375
49PRKD10.90004087
50RIPK40.89740496
51PDK20.89570509
52CDK11A0.89302298
53BMX0.88337208
54FGR0.87004899
55IRAK10.85870881
56NEK20.85715931
57CDK180.84856137
58CSK0.83768246
59TRIM280.83500925
60EIF2AK20.81315716
61CDK80.80873243
62ERBB20.80482418
63CDK40.79703837
64MARK10.79126515
65RPS6KA60.78711313
66STK160.78402978
67MKNK20.77898407
68CAMK1D0.77729301
69EPHA40.76935855
70PIM20.74809089
71IGF1R0.72103638
72ADRBK10.71665461
73EPHB20.68650738
74MAPKAPK50.68644038
75KIT0.67499607
76PRKACB0.67021871
77UHMK10.66785727
78INSR0.66732320
79PRKCQ0.64870397
80PRKCB0.64214603
81PRKCE0.63608839
82CAMK10.63117529
83MST40.62250624
84AURKA0.61054309
85MARK20.60715280
86CSF1R0.60411158
87CSNK1G20.60153213
88PINK10.59905307
89OXSR10.59837635
90ROCK20.57587605
91TBK10.57327928
92CSNK1D0.57202516
93TLK10.56530847
94ARAF0.55477564
95LIMK10.55449841
96MTOR0.54755270
97PHKG10.54592562
98PHKG20.54592562
99BCKDK0.54347117
100STK110.54336584
101CDK140.54267605
102NLK0.53711518
103MAPK110.52512973
104RPS6KA50.52357625
105ATR0.52024970
106MAP2K40.51658616
107KSR10.51653971
108MAP3K70.50857253
109PAK10.49796178
110MAPK80.49790653
111DAPK10.48636030
112NTRK10.47855713
113RPS6KA30.47300804
114JAK30.46988909
115CAMK2B0.46921973
116TGFBR10.46519485
117MST1R0.46022451
118MKNK10.43917771
119NEK60.43845443
120ICK0.42854053
121CHEK20.42801912
122CDK50.42700695
123DYRK1B0.42495987
124SGK2230.42398393
125SGK4940.42398393
126PRKAA10.41805481
127ADRBK20.40594317
128CAMK2A0.40580280
129CAMK1G0.40118683
130MAPK100.39754787
131MAP3K40.39218791
132HIPK20.39175663
133GRK10.39090490
134EEF2K0.38582686
135EPHB10.38189040
136TAOK20.37611413
137PRKCG0.37049626
138MAPK120.35778044
139MAP3K90.35580312
140RPS6KA20.34540653
141RPS6KC10.34372097
142RPS6KL10.34372097
143PRKCH0.33620292
144MELK0.33530055
145PLK10.33414990
146IKBKB0.32187946
147CDC42BPA0.29483510
148MINK10.28885854
149DYRK1A0.28880994
150PRKCD0.28303028
151PRKACA0.28265660
152STK380.28264109
153PRKCI0.28005452
154DYRK30.25728128
155CSNK1G30.25516116
156CAMK2G0.25295418
157IKBKE0.24847617
158CDK10.24376424
159BMPR20.24247224
160BRAF0.21891805
161SGK30.20954875
162EPHA20.19811948
163MAP2K10.19456193
164CAMKK20.17700476
165GSK3B0.17442179
166CDK20.16986403
167MAPK30.16614933
168AKT10.16036546
169TIE10.14965216
170LYN0.14023153

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001306.83509108
2Ribosome_Homo sapiens_hsa030103.54345626
3Glycosaminoglycan degradation_Homo sapiens_hsa005313.01530129
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.86653979
5Oxidative phosphorylation_Homo sapiens_hsa001902.85691243
6Nicotine addiction_Homo sapiens_hsa050332.68336231
7Fructose and mannose metabolism_Homo sapiens_hsa000512.63912043
8Glutamatergic synapse_Homo sapiens_hsa047242.62147863
9Circadian entrainment_Homo sapiens_hsa047132.58450164
10Morphine addiction_Homo sapiens_hsa050322.45919628
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.18999447
12Serotonergic synapse_Homo sapiens_hsa047262.15087103
13Alzheimers disease_Homo sapiens_hsa050102.14458274
14GABAergic synapse_Homo sapiens_hsa047272.13955337
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.12641697
16Parkinsons disease_Homo sapiens_hsa050122.11369752
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.08525492
18Steroid biosynthesis_Homo sapiens_hsa001002.01072148
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.83464497
20Sulfur relay system_Homo sapiens_hsa041221.83273409
21Taste transduction_Homo sapiens_hsa047421.79510531
22Cholinergic synapse_Homo sapiens_hsa047251.79497978
23Synaptic vesicle cycle_Homo sapiens_hsa047211.69265080
24Amphetamine addiction_Homo sapiens_hsa050311.69120575
25Dopaminergic synapse_Homo sapiens_hsa047281.61328394
26Long-term potentiation_Homo sapiens_hsa047201.60054428
27Vitamin digestion and absorption_Homo sapiens_hsa049771.59297674
28Fanconi anemia pathway_Homo sapiens_hsa034601.55938079
29Phototransduction_Homo sapiens_hsa047441.55457622
30Calcium signaling pathway_Homo sapiens_hsa040201.51043950
31Axon guidance_Homo sapiens_hsa043601.50781005
32Ether lipid metabolism_Homo sapiens_hsa005651.50231039
33Cocaine addiction_Homo sapiens_hsa050301.48554708
34Long-term depression_Homo sapiens_hsa047301.45779556
35Huntingtons disease_Homo sapiens_hsa050161.45213574
36Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.44367953
37Olfactory transduction_Homo sapiens_hsa047401.42705863
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.41312828
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.40775549
40Insulin secretion_Homo sapiens_hsa049111.38705095
41Protein export_Homo sapiens_hsa030601.33334308
42Vibrio cholerae infection_Homo sapiens_hsa051101.32140164
43Fatty acid elongation_Homo sapiens_hsa000621.28516696
44Cardiac muscle contraction_Homo sapiens_hsa042601.27880505
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.27647641
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.25807880
47Collecting duct acid secretion_Homo sapiens_hsa049661.20185219
48Melanogenesis_Homo sapiens_hsa049161.14877250
49RNA polymerase_Homo sapiens_hsa030201.06758832
50Ovarian steroidogenesis_Homo sapiens_hsa049131.04570496
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04195000
52African trypanosomiasis_Homo sapiens_hsa051431.03887754
53Phospholipase D signaling pathway_Homo sapiens_hsa040721.02192086
54Maturity onset diabetes of the young_Homo sapiens_hsa049501.02072945
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.01007649
56Wnt signaling pathway_Homo sapiens_hsa043100.97519948
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94650152
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94198840
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93671473
60Aldosterone synthesis and secretion_Homo sapiens_hsa049250.91966416
61Sphingolipid metabolism_Homo sapiens_hsa006000.89145109
62mTOR signaling pathway_Homo sapiens_hsa041500.88421984
63Lysine degradation_Homo sapiens_hsa003100.85270140
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80675308
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79988318
66ErbB signaling pathway_Homo sapiens_hsa040120.79654812
67Rheumatoid arthritis_Homo sapiens_hsa053230.79594872
68Pyruvate metabolism_Homo sapiens_hsa006200.79537009
69Oxytocin signaling pathway_Homo sapiens_hsa049210.78677896
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77877109
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.74211683
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72967273
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72579372
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69275959
75Gastric acid secretion_Homo sapiens_hsa049710.68102500
76Circadian rhythm_Homo sapiens_hsa047100.66647551
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66532585
78Base excision repair_Homo sapiens_hsa034100.65529645
79Basal transcription factors_Homo sapiens_hsa030220.64678507
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63841090
81Chemical carcinogenesis_Homo sapiens_hsa052040.63523173
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63327359
83Alcoholism_Homo sapiens_hsa050340.62816288
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61397080
85Lysosome_Homo sapiens_hsa041420.60114417
86cAMP signaling pathway_Homo sapiens_hsa040240.60021481
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58222109
88Choline metabolism in cancer_Homo sapiens_hsa052310.57715855
89Gap junction_Homo sapiens_hsa045400.54999393
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53726231
91GnRH signaling pathway_Homo sapiens_hsa049120.52833156
92Hippo signaling pathway_Homo sapiens_hsa043900.52199206
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.50885808
94Phagosome_Homo sapiens_hsa041450.50691174
95Type I diabetes mellitus_Homo sapiens_hsa049400.50414595
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49992958
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.49514066
98Nitrogen metabolism_Homo sapiens_hsa009100.48512133
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48181006
100Renin secretion_Homo sapiens_hsa049240.46184887
101Purine metabolism_Homo sapiens_hsa002300.45186072
102Homologous recombination_Homo sapiens_hsa034400.45121788
103Insulin signaling pathway_Homo sapiens_hsa049100.44341853
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44049111
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43801234
106Other glycan degradation_Homo sapiens_hsa005110.42958489
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42918728
108Arginine biosynthesis_Homo sapiens_hsa002200.42013987
109Linoleic acid metabolism_Homo sapiens_hsa005910.41982442
110Basal cell carcinoma_Homo sapiens_hsa052170.40150394
111Ras signaling pathway_Homo sapiens_hsa040140.39667412
112Salivary secretion_Homo sapiens_hsa049700.38989470
113Bladder cancer_Homo sapiens_hsa052190.38635874
114Insulin resistance_Homo sapiens_hsa049310.38471529
115Prion diseases_Homo sapiens_hsa050200.36984966
116Type II diabetes mellitus_Homo sapiens_hsa049300.36611925
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.36134090
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35450202
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35081243
120Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.34329117
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32662338
122Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.32068001
123Hedgehog signaling pathway_Homo sapiens_hsa043400.31754454
124Proteasome_Homo sapiens_hsa030500.31332759
125VEGF signaling pathway_Homo sapiens_hsa043700.30284262
126Fatty acid biosynthesis_Homo sapiens_hsa000610.30241082
127Endocytosis_Homo sapiens_hsa041440.30198531
128Fatty acid degradation_Homo sapiens_hsa000710.29136439
129Mineral absorption_Homo sapiens_hsa049780.28824038
130Malaria_Homo sapiens_hsa051440.27447121
131Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.27413986
132Dorso-ventral axis formation_Homo sapiens_hsa043200.27104911
133Metabolic pathways_Homo sapiens_hsa011000.27087654
134Sulfur metabolism_Homo sapiens_hsa009200.27028843
135ABC transporters_Homo sapiens_hsa020100.26902600
136Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.24815851
137Notch signaling pathway_Homo sapiens_hsa043300.24570058
138Estrogen signaling pathway_Homo sapiens_hsa049150.24552663
139Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.23753149
140Glutathione metabolism_Homo sapiens_hsa004800.23629615
141Inositol phosphate metabolism_Homo sapiens_hsa005620.23445856
142Pyrimidine metabolism_Homo sapiens_hsa002400.23263246
143N-Glycan biosynthesis_Homo sapiens_hsa005100.22955127
144Bile secretion_Homo sapiens_hsa049760.21667440
145PPAR signaling pathway_Homo sapiens_hsa033200.21576460
146Fat digestion and absorption_Homo sapiens_hsa049750.19962071
147Sphingolipid signaling pathway_Homo sapiens_hsa040710.19116545
148Hematopoietic cell lineage_Homo sapiens_hsa046400.18675572
149Non-homologous end-joining_Homo sapiens_hsa034500.17577551
150NOD-like receptor signaling pathway_Homo sapiens_hsa046210.16922198
151Chemokine signaling pathway_Homo sapiens_hsa040620.16879573
152cGMP-PKG signaling pathway_Homo sapiens_hsa040220.16720916
153Glycerolipid metabolism_Homo sapiens_hsa005610.13694771
154Peroxisome_Homo sapiens_hsa041460.12915569
155RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.12616694
156Biosynthesis of amino acids_Homo sapiens_hsa012300.11910302
157Cell cycle_Homo sapiens_hsa041100.11072789
158Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.08820472
159Histidine metabolism_Homo sapiens_hsa003400.08587669
160Hepatitis C_Homo sapiens_hsa051600.07826449
161Neurotrophin signaling pathway_Homo sapiens_hsa047220.07471219

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