LENG8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)5.18168015
2locomotory exploration behavior (GO:0035641)4.73204485
3mannose metabolic process (GO:0006013)4.69510281
4sodium ion export (GO:0071436)4.62964072
5positive regulation of gamma-delta T cell activation (GO:0046645)4.33931321
6regulation of short-term neuronal synaptic plasticity (GO:0048172)4.27227543
7synaptic vesicle maturation (GO:0016188)4.07747561
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.07092859
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.02728380
10negative regulation of cell killing (GO:0031342)4.02728380
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.98146690
12cellular potassium ion homeostasis (GO:0030007)3.97908086
13antigen processing and presentation of endogenous antigen (GO:0019883)3.88876118
14thymic T cell selection (GO:0045061)3.86082402
15cerebellar Purkinje cell differentiation (GO:0021702)3.85326976
16antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.84881749
17positive thymic T cell selection (GO:0045059)3.84739371
18positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.82869416
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.73431410
20regulation of gamma-delta T cell differentiation (GO:0045586)3.66665407
21regulation of gamma-delta T cell activation (GO:0046643)3.66503379
22negative thymic T cell selection (GO:0045060)3.65944012
23response to muramyl dipeptide (GO:0032495)3.64822251
24positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.58794087
25establishment of nucleus localization (GO:0040023)3.51718767
26cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.49638467
27regulation of histone H3-K27 methylation (GO:0061085)3.49158508
28cell communication by electrical coupling (GO:0010644)3.41889318
29negative T cell selection (GO:0043383)3.40809331
30regulation of ARF protein signal transduction (GO:0032012)3.40369556
31positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.39678220
32T cell selection (GO:0045058)3.35618380
33histone H3-K4 trimethylation (GO:0080182)3.34642567
34synaptic vesicle docking involved in exocytosis (GO:0016081)3.33444325
35membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.32487894
36potassium ion import (GO:0010107)3.31310713
37cytoskeletal anchoring at plasma membrane (GO:0007016)3.28756765
38histone H3-K36 demethylation (GO:0070544)3.27959740
39layer formation in cerebral cortex (GO:0021819)3.27740947
40regulation of clathrin-mediated endocytosis (GO:2000369)3.27006695
41response to pheromone (GO:0019236)3.20686505
42vocalization behavior (GO:0071625)3.19167654
43positive T cell selection (GO:0043368)3.16828369
44regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.13267197
45dendritic spine morphogenesis (GO:0060997)3.12505954
46germinal center formation (GO:0002467)3.09335982
47positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.07715762
48potassium ion homeostasis (GO:0055075)3.07515283
49ionotropic glutamate receptor signaling pathway (GO:0035235)3.04849470
50regulation of synapse structural plasticity (GO:0051823)3.03117161
51negative regulation of cytosolic calcium ion concentration (GO:0051481)3.02154071
52gamma-aminobutyric acid transport (GO:0015812)3.00869758
53cellular sodium ion homeostasis (GO:0006883)3.00662115
54detection of bacterium (GO:0016045)2.98307316
55positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.98044420
56synaptic vesicle exocytosis (GO:0016079)2.97342882
57regulation of glutamate receptor signaling pathway (GO:1900449)2.96072407
58dendrite morphogenesis (GO:0048813)2.95090017
59response to laminar fluid shear stress (GO:0034616)2.92830056
60neurotransmitter secretion (GO:0007269)2.91716029
61glutamate secretion (GO:0014047)2.91327641
62B cell receptor signaling pathway (GO:0050853)2.91104499
63membrane depolarization during action potential (GO:0086010)2.89781753
64regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.89678974
65negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.88711732
66detection of other organism (GO:0098543)2.84620819
67negative regulation of myotube differentiation (GO:0010832)2.82957520
68signal complex assembly (GO:0007172)2.81328279
69regulation of ARF GTPase activity (GO:0032312)2.81266896
70histone H3-K9 demethylation (GO:0033169)2.79173316
71neuromuscular process controlling balance (GO:0050885)2.78038840
72stress granule assembly (GO:0034063)2.77498501
73leukocyte aggregation (GO:0070486)2.76746715
74cell differentiation in hindbrain (GO:0021533)2.76106329
75histone H3-K4 methylation (GO:0051568)2.75778821
76exploration behavior (GO:0035640)2.74815633
77histone H4 deacetylation (GO:0070933)2.74496570
78regulation of neuronal synaptic plasticity (GO:0048168)2.73834253
79neuronal action potential propagation (GO:0019227)2.73082659
80positive regulation by symbiont of host defense response (GO:0052509)2.72843060
81modulation by symbiont of host defense response (GO:0052031)2.72843060
82modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.72843060
83modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.72843060
84positive regulation by organism of defense response of other organism involved in symbiotic interact2.72843060
85modulation by symbiont of host immune response (GO:0052553)2.72843060
86regulation of synaptic vesicle exocytosis (GO:2000300)2.71342021
87glycine transport (GO:0015816)2.71260841
88positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.70732018
89activation of protein kinase A activity (GO:0034199)2.69875985
90long-term memory (GO:0007616)2.68962799
91positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.68893494
92histone lysine demethylation (GO:0070076)2.68205810
93positive regulation of CREB transcription factor activity (GO:0032793)2.67353172
94synaptic vesicle endocytosis (GO:0048488)2.67248695
95cerebellar granule cell differentiation (GO:0021707)2.65281741
96synaptic transmission, glutamatergic (GO:0035249)2.64985036
97activation of JUN kinase activity (GO:0007257)2.64904168
98cell communication involved in cardiac conduction (GO:0086065)2.64660656
99tolerance induction (GO:0002507)2.64404847
100regulation of type I interferon-mediated signaling pathway (GO:0060338)2.64220442
101regulation of B cell receptor signaling pathway (GO:0050855)2.62247647
102neuronal ion channel clustering (GO:0045161)2.61279617
103prepulse inhibition (GO:0060134)2.60633866
104histone H3 deacetylation (GO:0070932)2.58527071
105negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.56401614
106positive regulation of protein deacetylation (GO:0090312)2.55487094
107glutamate receptor signaling pathway (GO:0007215)2.54015190
108negative regulation of granulocyte differentiation (GO:0030853)2.53523153
109histone demethylation (GO:0016577)2.53036117
110positive regulation of synapse maturation (GO:0090129)2.53032865
111regulation of long-term neuronal synaptic plasticity (GO:0048169)2.53005546
112auditory behavior (GO:0031223)2.52274457
113regulation of extracellular matrix disassembly (GO:0010715)2.52209059
114positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.51385336
115macrophage activation involved in immune response (GO:0002281)2.51367894
116regulation of necroptotic process (GO:0060544)2.50585250
117regulation of T-helper 2 cell differentiation (GO:0045628)2.50073882
118semaphorin-plexin signaling pathway (GO:0071526)2.47374003
119endothelial cell chemotaxis (GO:0035767)2.46874243
120cell migration in hindbrain (GO:0021535)2.46222102
121negative regulation of lymphocyte mediated immunity (GO:0002707)2.45025293
122NIK/NF-kappaB signaling (GO:0038061)2.44962426
123membrane repolarization (GO:0086009)2.44798782
124positive regulation of granulocyte differentiation (GO:0030854)2.44297060
125negative regulation of leukocyte mediated immunity (GO:0002704)2.43975842
126response to auditory stimulus (GO:0010996)2.43725186
127L-amino acid import (GO:0043092)2.43606940
128nerve growth factor signaling pathway (GO:0038180)2.43230759
129proline transport (GO:0015824)2.43090851
130positive regulation of histone deacetylation (GO:0031065)2.42921388
131alanine transport (GO:0032328)2.40979659
132peptidyl-tyrosine autophosphorylation (GO:0038083)2.40751661
133positive regulation of potassium ion transmembrane transport (GO:1901381)2.39968550
134retrograde transport, vesicle recycling within Golgi (GO:0000301)2.39894402
135phospholipid scrambling (GO:0017121)2.38979006
136axonal fasciculation (GO:0007413)2.38434661
137response to interleukin-15 (GO:0070672)2.38150034
138regulation of granulocyte differentiation (GO:0030852)2.37936491
139regulation of synaptic vesicle transport (GO:1902803)2.37757615
140positive regulation of Rap GTPase activity (GO:0032854)2.36974799
141embryonic process involved in female pregnancy (GO:0060136)2.36585992
142nucleus localization (GO:0051647)2.36426302
143establishment of protein localization to Golgi (GO:0072600)2.36196280
144regulation of excitatory postsynaptic membrane potential (GO:0060079)2.35514262
145membrane hyperpolarization (GO:0060081)2.35064818
146insulin-like growth factor receptor signaling pathway (GO:0048009)2.34098187
1473-UTR-mediated mRNA stabilization (GO:0070935)2.33380437
148regulation of postsynaptic membrane potential (GO:0060078)2.33275994
149protein localization to synapse (GO:0035418)2.33104195
150regulation of dendritic cell antigen processing and presentation (GO:0002604)2.32559434
151detection of external biotic stimulus (GO:0098581)2.32555128
152neuromuscular process controlling posture (GO:0050884)2.32433673
153regulation of NFAT protein import into nucleus (GO:0051532)2.32026975
154adherens junction assembly (GO:0034333)2.31520544
155regulation of leukocyte degranulation (GO:0043300)2.31520024
156positive regulation of B cell differentiation (GO:0045579)2.31259464
157cell-substrate adherens junction assembly (GO:0007045)2.30960060
158focal adhesion assembly (GO:0048041)2.30960060
159modulation by virus of host process (GO:0019054)2.30743003
160suckling behavior (GO:0001967)2.30394880
161mucosal-associated lymphoid tissue development (GO:0048537)2.30002676
162Peyers patch development (GO:0048541)2.30002676
163regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.29461152
164neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.29244890
165CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.28837715
166antigen processing and presentation via MHC class Ib (GO:0002475)2.28104082
167response to type I interferon (GO:0034340)2.27153493
168T cell migration (GO:0072678)2.26553042
169intracellular estrogen receptor signaling pathway (GO:0030520)2.25876941
170innervation (GO:0060384)2.25579294
171membrane depolarization (GO:0051899)2.25472824
172protein targeting to Golgi (GO:0000042)2.24934923
173negative regulation of bone resorption (GO:0045779)2.24705056
174regulation of B cell differentiation (GO:0045577)2.24367369
175response to peptidoglycan (GO:0032494)2.24115312
176chemosensory behavior (GO:0007635)2.23366638
177negative regulation of toll-like receptor signaling pathway (GO:0034122)2.22830172
178regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.22706281
179response to fluid shear stress (GO:0034405)2.22572650
180stress fiber assembly (GO:0043149)2.22539768
181regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.22430002
182modulation by symbiont of host cellular process (GO:0044068)2.22392446
183regulation of Rap GTPase activity (GO:0032317)2.20795146
184positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.19222586
185growth hormone secretion (GO:0030252)2.19219422
186neurotransmitter-gated ion channel clustering (GO:0072578)2.18437339
187positive regulation of sodium ion transport (GO:0010765)2.17996894
188neuron-neuron synaptic transmission (GO:0007270)2.17989614
189neurotransmitter transport (GO:0006836)2.15459020
190neuromuscular junction development (GO:0007528)2.14340741

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.40723941
2DROSHA_22980978_ChIP-Seq_HELA_Human2.92828608
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.92754655
4RARB_27405468_Chip-Seq_BRAIN_Mouse2.27688061
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.14915255
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.10007876
7VDR_24763502_ChIP-Seq_THP-1_Human2.09045143
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.06944104
9KDM2B_26808549_Chip-Seq_SUP-B15_Human2.05661820
10KDM2B_26808549_Chip-Seq_K562_Human2.05573750
11MAF_26560356_Chip-Seq_TH1_Human2.01515844
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.01280358
13IKZF1_21737484_ChIP-ChIP_HCT116_Human1.99298577
14RARG_19884340_ChIP-ChIP_MEFs_Mouse1.98417367
15EZH2_18974828_ChIP-Seq_MESCs_Mouse1.97942157
16RNF2_18974828_ChIP-Seq_MESCs_Mouse1.97942157
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96139384
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93608208
19KDM2B_26808549_Chip-Seq_DND41_Human1.92137217
20RACK7_27058665_Chip-Seq_MCF-7_Human1.86625790
21MTF2_20144788_ChIP-Seq_MESCs_Mouse1.86375204
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.86246370
23TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.86130192
24UTX_26944678_Chip-Seq_JUKART_Human1.84434278
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.83228913
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.78954790
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.78539235
28MAF_26560356_Chip-Seq_TH2_Human1.74592614
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.74284048
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.73282171
31SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.72667026
32WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.71232068
33ZFP281_18757296_ChIP-ChIP_E14_Mouse1.70004860
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.69930659
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.69572953
36DNAJC2_21179169_ChIP-ChIP_NT2_Human1.67347520
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.66267460
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.66155955
39RNF2_27304074_Chip-Seq_ESCs_Mouse1.64913691
40ZFP281_27345836_Chip-Seq_ESCs_Mouse1.64464788
41* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.63757328
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.62180297
43REST_21632747_ChIP-Seq_MESCs_Mouse1.61411886
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.61035153
45KDM2B_26808549_Chip-Seq_JURKAT_Human1.60477639
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.59963228
47* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.59684611
48CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.58581050
49TP63_17297297_ChIP-ChIP_HaCaT_Human1.57491018
50SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56090821
51SCL_19346495_ChIP-Seq_HPC-7_Human1.56000557
52P68_20966046_ChIP-Seq_HELA_Human1.55429144
53SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.54542175
54SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.54503230
55WT1_25993318_ChIP-Seq_PODOCYTE_Human1.53974082
56CTCF_27219007_Chip-Seq_ERYTHROID_Human1.53824619
57GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.53788949
58FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.53645098
59SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.53228024
60NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.53141042
61LXR_22292898_ChIP-Seq_THP-1_Human1.52525021
62KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.50405789
63SA1_27219007_Chip-Seq_ERYTHROID_Human1.49602765
64EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.47450767
65KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.46820996
66BP1_19119308_ChIP-ChIP_Hs578T_Human1.45334970
67STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.45181302
68NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43622238
69RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.42309263
70FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.42018405
71ESR2_21235772_ChIP-Seq_MCF-7_Human1.40211981
72TCF7_22412390_ChIP-Seq_EML_Mouse1.39190065
73BRD4_27068464_Chip-Seq_AML-cells_Mouse1.39178753
74EZH2_27304074_Chip-Seq_ESCs_Mouse1.38831934
75REST_18959480_ChIP-ChIP_MESCs_Mouse1.38129202
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36984826
77TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34585552
78NCOR1_26117541_ChIP-Seq_K562_Human1.29449715
79SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27468834
80UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.26306032
81EED_16625203_ChIP-ChIP_MESCs_Mouse1.24574795
82KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23893221
83RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.23756608
84TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21919192
85MYB_26560356_Chip-Seq_TH1_Human1.21857566
86AR_19668381_ChIP-Seq_PC3_Human1.21685316
87AHR_22903824_ChIP-Seq_MCF-7_Human1.20667996
88ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20308286
89* ELF1_20517297_ChIP-Seq_JURKAT_Human1.18517192
90RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.18391371
91RING1B_27294783_Chip-Seq_ESCs_Mouse1.18033721
92BCOR_27268052_Chip-Seq_Bcells_Human1.17764046
93* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.16153161
94MYC_22102868_ChIP-Seq_BL_Human1.15817865
95ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15427489
96GBX2_23144817_ChIP-Seq_PC3_Human1.15065717
97TET1_21451524_ChIP-Seq_MESCs_Mouse1.14129248
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13859196
99KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13585386
100SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13287358
101MYB_21317192_ChIP-Seq_ERMYB_Mouse1.11802542
102ARNT_22903824_ChIP-Seq_MCF-7_Human1.11484288
103CREB1_26743006_Chip-Seq_LNCaP_Human1.11310196
104TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.10971817
105MYB_26560356_Chip-Seq_TH2_Human1.10223921
106IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.09807393
107GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09475203
108BCL6_27268052_Chip-Seq_Bcells_Human1.08663547
109OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07526469
110IRF8_27001747_Chip-Seq_BMDM_Mouse1.07418977
111SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07148892
112* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06622530
113AR_21572438_ChIP-Seq_LNCaP_Human1.06254976
114SMC4_20622854_ChIP-Seq_HELA_Human1.06242029
115CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04670925
116CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04075769
117TP63_22573176_ChIP-Seq_HFKS_Human1.03788889
118FOXA2_19822575_ChIP-Seq_HepG2_Human1.03706999
119P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02233734
120* ISL1_27105846_Chip-Seq_CPCs_Mouse1.01921500
121CTCF_27219007_Chip-Seq_Bcells_Human1.01887349
122CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01192273
123STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.01009313
124STAT4_19710469_ChIP-ChIP_TH1__Mouse0.99786795
125* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99404211
126RING1B_27294783_Chip-Seq_NPCs_Mouse0.98606893
127NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98584034
128CLOCK_20551151_ChIP-Seq_293T_Human0.96853707
129TP53_16413492_ChIP-PET_HCT116_Human0.96652733
130SPI1_23127762_ChIP-Seq_K562_Human0.96529282
131SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95145926
132PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94627980
133SOX2_21211035_ChIP-Seq_LN229_Gbm0.94621808
134TET1_21490601_ChIP-Seq_MESCs_Mouse0.93875983
135E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93634364
136GATA1_19941826_ChIP-Seq_K562_Human0.93546759
137YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93022403
138NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.92499512
139MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.92270619
140SMAD4_21741376_ChIP-Seq_HESCs_Human0.92251550
141BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91386063
142RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91250231
143GATA1_19941827_ChIP-Seq_MEL_Mouse0.91004343
144RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.90995819
145* RUNX1_27514584_Chip-Seq_MCF-7_Human0.89999643
146TBX20_22080862_ChIP-Seq_HEART_Mouse0.89830888
147TBX20_22328084_ChIP-Seq_HEART_Mouse0.89830888
148RUNX_20019798_ChIP-Seq_JUKART_Human0.89792914
149SMAD3_21741376_ChIP-Seq_HESCs_Human0.89409990
150ESR1_20079471_ChIP-ChIP_T-47D_Human0.88589298
151VDR_21846776_ChIP-Seq_THP-1_Human0.87244441
152ELK3_25401928_ChIP-Seq_HUVEC_Human0.87199288
153PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87174229

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.71154837
2MP0000569_abnormal_digit_pigmentation3.47672311
3MP0003436_decreased_susceptibility_to3.45130015
4MP0008961_abnormal_basal_metabolism3.15999145
5MP0003635_abnormal_synaptic_transmissio3.14912223
6MP0003763_abnormal_thymus_physiology2.78514824
7MP0003303_peritoneal_inflammation2.67815373
8MP0009046_muscle_twitch2.66239321
9MP0008569_lethality_at_weaning2.38959411
10MP0005423_abnormal_somatic_nervous2.36220724
11MP0004270_analgesia2.33894765
12MP0002909_abnormal_adrenal_gland2.26321935
13MP0002064_seizures2.24299337
14MP0002063_abnormal_learning/memory/cond2.21339992
15MP0001835_abnormal_antigen_presentation2.19484511
16MP0009780_abnormal_chondrocyte_physiolo2.11910356
17MP0004885_abnormal_endolymph2.11014644
18MP0001800_abnormal_humoral_immune2.09873155
19MP0009745_abnormal_behavioral_response2.06675646
20MP0003283_abnormal_digestive_organ2.06221947
21MP0000685_abnormal_immune_system2.05944723
22MP0001790_abnormal_immune_system2.03578428
23MP0005387_immune_system_phenotype2.03578428
24MP0008260_abnormal_autophagy2.02514598
25MP0001486_abnormal_startle_reflex2.01284723
26MP0002396_abnormal_hematopoietic_system2.00879487
27MP0005058_abnormal_lysosome_morphology1.98127286
28MP0004947_skin_inflammation1.97440423
29MP0002653_abnormal_ependyma_morphology1.94661970
30MP0001348_abnormal_lacrimal_gland1.90291004
31MP0003091_abnormal_cell_migration1.89689057
32MP0000751_myopathy1.87333063
33MP0005000_abnormal_immune_tolerance1.87260584
34MP0003279_aneurysm1.80723727
35MP0002419_abnormal_innate_immunity1.79880164
36MP0005025_abnormal_response_to1.79031570
37MP0002572_abnormal_emotion/affect_behav1.77434911
38MP0005409_darkened_coat_color1.76380441
39MP0004145_abnormal_muscle_electrophysio1.76002835
40MP0003045_fibrosis1.75599013
41MP0004858_abnormal_nervous_system1.73581811
42MP0002822_catalepsy1.71754566
43MP0002272_abnormal_nervous_system1.71174669
44MP0002933_joint_inflammation1.70900642
45MP0002420_abnormal_adaptive_immunity1.68703578
46MP0002723_abnormal_immune_serum1.67265476
47MP0001819_abnormal_immune_cell1.66819209
48MP0005451_abnormal_body_composition1.66119398
49MP0001873_stomach_inflammation1.65462486
50MP0003724_increased_susceptibility_to1.64704693
51MP0010155_abnormal_intestine_physiology1.62206223
52MP0001958_emphysema1.60509672
53MP0002452_abnormal_antigen_presenting1.60277353
54MP0003329_amyloid_beta_deposits1.59821344
55MP0003172_abnormal_lysosome_physiology1.57803938
56MP0000778_abnormal_nervous_system1.57400156
57MP0002398_abnormal_bone_marrow1.56056449
58MP0005671_abnormal_response_to1.54297193
59MP0002998_abnormal_bone_remodeling1.50907598
60MP0002405_respiratory_system_inflammati1.49880061
61MP0001502_abnormal_circadian_rhythm1.48641526
62MP0003880_abnormal_central_pattern1.47337458
63MP0000703_abnormal_thymus_morphology1.47012709
64MP0002067_abnormal_sensory_capabilities1.45554348
65MP0001533_abnormal_skeleton_physiology1.45384589
66MP0000716_abnormal_immune_system1.42668863
67MP0009333_abnormal_splenocyte_physiolog1.41897442
68MP0001501_abnormal_sleep_pattern1.41642098
69MP0000955_abnormal_spinal_cord1.40689557
70MP0001440_abnormal_grooming_behavior1.40600405
71MP0003191_abnormal_cellular_cholesterol1.39761777
72MP0004130_abnormal_muscle_cell1.38976946
73MP0003866_abnormal_defecation1.38797404
74MP0002249_abnormal_larynx_morphology1.38709478
75MP0003122_maternal_imprinting1.36347169
76MP0004811_abnormal_neuron_physiology1.35833766
77MP0004381_abnormal_hair_follicle1.34163119
78MP0003787_abnormal_imprinting1.33604070
79MP0005551_abnormal_eye_electrophysiolog1.31588813
80MP0002184_abnormal_innervation1.31274556
81MP0002557_abnormal_social/conspecific_i1.30723940
82MP0001545_abnormal_hematopoietic_system1.30253279
83MP0005397_hematopoietic_system_phenotyp1.30253279
84MP0004233_abnormal_muscle_weight1.29019108
85MP0002089_abnormal_postnatal_growth/wei1.28827358
86MP0003566_abnormal_cell_adhesion1.28556353
87MP0000678_abnormal_parathyroid_gland1.27673986
88MP0004808_abnormal_hematopoietic_stem1.26764245
89MP0002882_abnormal_neuron_morphology1.26336106
90MP0003300_gastrointestinal_ulcer1.26186039
91MP0003633_abnormal_nervous_system1.24713955
92MP0002734_abnormal_mechanical_nocicepti1.24698064
93MP0005076_abnormal_cell_differentiation1.21498881
94MP0001851_eye_inflammation1.21428924
95MP0000858_altered_metastatic_potential1.21172884
96MP0002722_abnormal_immune_system1.17536271
97MP0003183_abnormal_peptide_metabolism1.17510703
98MP0003690_abnormal_glial_cell1.15162620
99MP0001299_abnormal_eye_distance/1.15072588
100MP0002429_abnormal_blood_cell1.13730864
101MP0002733_abnormal_thermal_nociception1.12327139
102MP0002166_altered_tumor_susceptibility1.12159508
103MP0003828_pulmonary_edema1.12135507
104MP0003453_abnormal_keratinocyte_physiol1.10631068
105MP0002152_abnormal_brain_morphology1.09083365
106MP0002009_preneoplasia1.08987562
107MP0005670_abnormal_white_adipose1.08557146
108MP0001968_abnormal_touch/_nociception1.08362980
109MP0005386_behavior/neurological_phenoty1.07535748
110MP0004924_abnormal_behavior1.07535748
111MP0003879_abnormal_hair_cell1.06892378
112MP0003137_abnormal_impulse_conducting1.06352294
113MP0005464_abnormal_platelet_physiology1.06284268
114MP0006072_abnormal_retinal_apoptosis1.04125135
115MP0000003_abnormal_adipose_tissue1.03836212
116MP0002066_abnormal_motor_capabilities/c1.03219616
117MP0000689_abnormal_spleen_morphology1.01077574
118MP0001970_abnormal_pain_threshold1.00299844
119MP0004085_abnormal_heartbeat1.00173241
120MP0004087_abnormal_muscle_fiber0.99853180
121MP0003631_nervous_system_phenotype0.99029707
122MP0004510_myositis0.98805865
123MP0003705_abnormal_hypodermis_morpholog0.98292756
124MP0005310_abnormal_salivary_gland0.98278556
125MP0004215_abnormal_myocardial_fiber0.97039349
126MP0002229_neurodegeneration0.96729747
127MP0006082_CNS_inflammation0.96543481
128MP0004084_abnormal_cardiac_muscle0.96515596
129MP0000747_muscle_weakness0.94690029
130MP0005375_adipose_tissue_phenotype0.93781055
131MP0003634_abnormal_glial_cell0.93682349
132MP0004036_abnormal_muscle_relaxation0.92232900
133MP0003632_abnormal_nervous_system0.91262643
134MP0001845_abnormal_inflammatory_respons0.90559810
135MP0000767_abnormal_smooth_muscle0.89908630
136MP0009840_abnormal_foam_cell0.89654310
137MP0009278_abnormal_bone_marrow0.89619929
138MP0001849_ear_inflammation0.88908702
139MP0009785_altered_susceptibility_to0.87710984
140MP0002069_abnormal_eating/drinking_beha0.86171955
141MP0001853_heart_inflammation0.85578998
142MP0000249_abnormal_blood_vessel0.84445693
143MP0009115_abnormal_fat_cell0.84043786
144MP0005023_abnormal_wound_healing0.83775706
145MP0006138_congestive_heart_failure0.83256588
146MP0010630_abnormal_cardiac_muscle0.82924876
147MP0008874_decreased_physiological_sensi0.82869204
148MP0005390_skeleton_phenotype0.82736825
149MP0008438_abnormal_cutaneous_collagen0.80794470
150MP0005646_abnormal_pituitary_gland0.80442068
151MP0002269_muscular_atrophy0.80403964
152MP0005187_abnormal_penis_morphology0.80161570
153MP0005666_abnormal_adipose_tissue0.79221519
154MP0005621_abnormal_cell_physiology0.79146936
155MP0001984_abnormal_olfaction0.78779441
156MP0002132_abnormal_respiratory_system0.78717094
157MP0004185_abnormal_adipocyte_glucose0.78107349
158MP0004264_abnormal_extraembryonic_tissu0.76884789
159MP0002234_abnormal_pharynx_morphology0.76197527
160MP0005167_abnormal_blood-brain_barrier0.76038104
161MP0000604_amyloidosis0.75636967
162MP0000920_abnormal_myelination0.75409662
163MP0002970_abnormal_white_adipose0.74531029
164MP0010769_abnormal_survival0.74437106
165MP0004043_abnormal_pH_regulation0.73299972
166MP0002090_abnormal_vision0.72258785
167MP0000733_abnormal_muscle_development0.71719860
168MP0005645_abnormal_hypothalamus_physiol0.71490029
169MP0003115_abnormal_respiratory_system0.71439298
170MP0002971_abnormal_brown_adipose0.70460220
171MP0002735_abnormal_chemical_nociception0.70162312
172MP0005253_abnormal_eye_physiology0.69556725
173MP0002082_postnatal_lethality0.69140379
174MP0010770_preweaning_lethality0.69140379
175MP0005360_urolithiasis0.68958960

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)4.52141474
2Eczematoid dermatitis (HP:0000976)3.65636325
3Broad face (HP:0000283)3.63693455
4Focal seizures (HP:0007359)3.37398000
5Macroorchidism (HP:0000053)3.36256865
6Hyperacusis (HP:0010780)3.32027546
7Hemiplegia (HP:0002301)3.28518765
8Action tremor (HP:0002345)3.28210112
9Genetic anticipation (HP:0003743)3.21811324
10Colitis (HP:0002583)3.05126157
11Neoplasm of the heart (HP:0100544)2.92680422
12Progressive cerebellar ataxia (HP:0002073)2.89437286
13Myokymia (HP:0002411)2.89056817
14Supranuclear gaze palsy (HP:0000605)2.87635105
15Increased IgE level (HP:0003212)2.87587296
16Dysmetric saccades (HP:0000641)2.75189215
17Focal motor seizures (HP:0011153)2.74544813
18Broad metatarsal (HP:0001783)2.73833974
19Elfin facies (HP:0004428)2.71902663
20Abnormality of the fingertips (HP:0001211)2.71755259
21Visual hallucinations (HP:0002367)2.64040361
22Insomnia (HP:0100785)2.62617503
23Cellulitis (HP:0100658)2.58549705
24Cerebral aneurysm (HP:0004944)2.56001679
25Gastrointestinal inflammation (HP:0004386)2.54495160
26Thin bony cortex (HP:0002753)2.53361512
27Impaired social interactions (HP:0000735)2.52594362
28Abnormal social behavior (HP:0012433)2.52594362
29Pointed chin (HP:0000307)2.47261399
30Abnormality of the lower motor neuron (HP:0002366)2.46380638
31Postural instability (HP:0002172)2.42107223
32Emphysema (HP:0002097)2.40130459
33Narrow palate (HP:0000189)2.38779131
34Papilledema (HP:0001085)2.38388801
35Inflammation of the large intestine (HP:0002037)2.37406624
36Dysdiadochokinesis (HP:0002075)2.28936726
37Cervical subluxation (HP:0003308)2.28556415
38Heterotopia (HP:0002282)2.27989660
39Ankle clonus (HP:0011448)2.26448060
40Protrusio acetabuli (HP:0003179)2.25456926
41Abnormal delayed hypersensitivity skin test (HP:0002963)2.25148506
42Difficulty running (HP:0009046)2.24000159
43Hemorrhage of the eye (HP:0011885)2.23967061
44Distal lower limb amyotrophy (HP:0008944)2.23640480
45Gingivitis (HP:0000230)2.22819486
46Impaired smooth pursuit (HP:0007772)2.22366363
47Obsessive-compulsive behavior (HP:0000722)2.19519502
48Panhypogammaglobulinemia (HP:0003139)2.17953391
49Gastrointestinal stroma tumor (HP:0100723)2.17125539
50Recurrent fungal infections (HP:0002841)2.16979310
51Upper limb amyotrophy (HP:0009129)2.16874353
52Distal upper limb amyotrophy (HP:0007149)2.16874353
53Pustule (HP:0200039)2.15982505
54Hemiparesis (HP:0001269)2.15874902
55Depression (HP:0000716)2.13295416
56Spontaneous hematomas (HP:0007420)2.13206830
57Gaze-evoked nystagmus (HP:0000640)2.13075099
58Epileptic encephalopathy (HP:0200134)2.12584634
59Myositis (HP:0100614)2.12350078
60Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.11676897
61Metaphyseal cupping (HP:0003021)2.11604324
62Abnormality of ocular smooth pursuit (HP:0000617)2.10747125
63Ventricular fibrillation (HP:0001663)2.09450123
64Shallow orbits (HP:0000586)2.09097649
65Renovascular hypertension (HP:0100817)2.08979962
66Dysmetria (HP:0001310)2.08833844
67Recurrent bacterial skin infections (HP:0005406)2.08002369
68Poor eye contact (HP:0000817)2.07753533
69Agammaglobulinemia (HP:0004432)2.07315646
70Prolonged bleeding time (HP:0003010)2.06932146
71Recurrent abscess formation (HP:0002722)2.05887311
72Dislocated radial head (HP:0003083)2.05655770
73Segmental peripheral demyelination/remyelination (HP:0003481)2.05649550
74Urinary bladder sphincter dysfunction (HP:0002839)2.05287002
75Meningitis (HP:0001287)2.04491447
76Disproportionate tall stature (HP:0001519)2.04258324
77Intention tremor (HP:0002080)2.03895614
78Slow saccadic eye movements (HP:0000514)2.03442130
79Malnutrition (HP:0004395)2.02149098
80Anal stenosis (HP:0002025)2.01837447
81Prolonged QT interval (HP:0001657)2.01833362
82Trigonocephaly (HP:0000243)2.01613727
83Aqueductal stenosis (HP:0002410)2.01349205
84Broad-based gait (HP:0002136)2.01019665
85Recurrent viral infections (HP:0004429)2.00639850
86Truncal ataxia (HP:0002078)1.99885183
87Gastrointestinal infarctions (HP:0005244)1.98958918
88Abnormality of macrophages (HP:0004311)1.98253969
89Turricephaly (HP:0000262)1.97396248
90Interstitial pulmonary disease (HP:0006530)1.97203964
91Abnormality of binocular vision (HP:0011514)1.96311434
92Diplopia (HP:0000651)1.96311434
93Overriding aorta (HP:0002623)1.95880230
94Urinary urgency (HP:0000012)1.95111769
95Onion bulb formation (HP:0003383)1.94876393
96Scanning speech (HP:0002168)1.93383795
97Flat acetabular roof (HP:0003180)1.92918970
98Dysostosis multiplex (HP:0000943)1.92705190
99Stridor (HP:0010307)1.91756086
100Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.90544553
101Hand muscle atrophy (HP:0009130)1.88975486
102Dilatation of the ascending aorta (HP:0005111)1.88525829
103Abnormality of the radial head (HP:0003995)1.88471914
104Increased connective tissue (HP:0009025)1.88131703
105Open mouth (HP:0000194)1.87483631
106Enlarged penis (HP:0000040)1.86281399
107Mediastinal lymphadenopathy (HP:0100721)1.85653399
108Febrile seizures (HP:0002373)1.85152866
109Polygenic inheritance (HP:0010982)1.84787067
110Neuronal loss in central nervous system (HP:0002529)1.84515226
111Aortic aneurysm (HP:0004942)1.84393290
112Bronchomalacia (HP:0002780)1.83319792
113Vertebral arch anomaly (HP:0008438)1.83198547
114Mask-like facies (HP:0000298)1.83133842
115Centrally nucleated skeletal muscle fibers (HP:0003687)1.82804586
116Easy fatigability (HP:0003388)1.82582914
117Mitral regurgitation (HP:0001653)1.82158138
118Biconcave vertebral bodies (HP:0004586)1.80396267
119Abnormality of the nasal mucosa (HP:0000433)1.80326223
120Central scotoma (HP:0000603)1.80270749
121Bundle branch block (HP:0011710)1.79747789
122Chronic mucocutaneous candidiasis (HP:0002728)1.78438821
123Recurrent cutaneous fungal infections (HP:0011370)1.78438821
124Mucopolysacchariduria (HP:0008155)1.77228331
125Urinary glycosaminoglycan excretion (HP:0003541)1.77228331
126Increased variability in muscle fiber diameter (HP:0003557)1.77127912
127Chronic obstructive pulmonary disease (HP:0006510)1.76795061
128Obstructive lung disease (HP:0006536)1.76795061
129Nasal polyposis (HP:0100582)1.76769806
130Stereotypic behavior (HP:0000733)1.76168141
131Impaired vibration sensation in the lower limbs (HP:0002166)1.75791700
132Annular pancreas (HP:0001734)1.74872365
133Spinal canal stenosis (HP:0003416)1.74485896
134Asymmetric septal hypertrophy (HP:0001670)1.74356735
135Seborrheic dermatitis (HP:0001051)1.73280685
136J-shaped sella turcica (HP:0002680)1.73016905
137Recurrent gram-negative bacterial infections (HP:0005420)1.72426077
138Restrictive lung disease (HP:0002091)1.72108689
139Abnormality of the thoracic spine (HP:0100711)1.71737411
140Long toe (HP:0010511)1.71630119
141Exercise-induced myalgia (HP:0003738)1.71336707
142Renal duplication (HP:0000075)1.71236756
143Aneurysm (HP:0002617)1.70671985
144Abnormality of the astrocytes (HP:0100707)1.70237871
145Astrocytoma (HP:0009592)1.70237871
146Syringomyelia (HP:0003396)1.70204608
147Spinal cord lesions (HP:0100561)1.70204608
148Urethral obstruction (HP:0000796)1.69871203
149Status epilepticus (HP:0002133)1.69744962
150Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.69040240
151Pseudobulbar signs (HP:0002200)1.68733254
152Mitral valve prolapse (HP:0001634)1.67985418
153Vasculitis (HP:0002633)1.67652385
154Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.67383227
155Short 4th metacarpal (HP:0010044)1.67383227
156Atelectasis (HP:0100750)1.66892159
157Long eyelashes (HP:0000527)1.66846582
158Spastic gait (HP:0002064)1.65754383
159Ulnar bowing (HP:0003031)1.65627155
160Persistence of primary teeth (HP:0006335)1.64979015
161Abnormality of mucopolysaccharide metabolism (HP:0011020)1.64953773
162Abnormality of polysaccharide metabolism (HP:0011012)1.64953773
163Abnormality of glycosaminoglycan metabolism (HP:0004371)1.64953773
164Abnormal EKG (HP:0003115)1.63737922
165Postural tremor (HP:0002174)1.63483920
166Long palpebral fissure (HP:0000637)1.63417110
167Spondylolisthesis (HP:0003302)1.62229764
168Chest pain (HP:0100749)1.62088532
169Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.62021282
170Oligodactyly (hands) (HP:0001180)1.61909636
171Hypertriglyceridemia (HP:0002155)1.61420514
172Tetraplegia (HP:0002445)1.59009695
173Hypoplastic nipples (HP:0002557)1.58864161
174Megalencephaly (HP:0001355)1.57681485
175Abnormal eating behavior (HP:0100738)1.57557987
176Generalized hypotonia (HP:0001290)1.57154006
177Excessive salivation (HP:0003781)1.56443736
178Drooling (HP:0002307)1.56443736
179Absence seizures (HP:0002121)1.56354884
180Abnormality of saccadic eye movements (HP:0000570)1.56091244
181Hypoplastic ischia (HP:0003175)1.56075267
182Lower limb amyotrophy (HP:0007210)1.56006649

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1G2.84071752
2MAP4K12.79631914
3SIK22.58178745
4MAP3K92.42027571
5NTRK32.31300408
6TRIB32.19329459
7CAMK1D2.16078978
8RIPK12.12861723
9SIK12.12850849
10NTRK22.12605712
11ICK2.09824280
12SMG12.00195949
13CDK121.95478784
14TYRO31.82144472
15SIK31.81462514
16TYK21.76483100
17MAP3K101.69596195
18PAK61.68000365
19STK381.65985763
20PRKD31.65203555
21DAPK21.61363474
22ERN11.60905203
23MAP2K31.59090641
24KSR11.55430673
25MAP3K71.53816620
26ZAP701.51804119
27CDC42BPA1.49158221
28EPHA41.47798404
29BLK1.45196010
30MARK21.44497032
31TAOK11.43204091
32BRD41.43118001
33FGFR21.40917980
34WNK11.38009507
35DMPK1.36579590
36PDGFRA1.31413766
37MAP3K41.30565367
38CAMKK11.25021912
39EEF2K1.22263887
40PRKCH1.22161015
41NTRK11.20940528
42MAP3K141.20099380
43MAP3K131.18767819
44TTN1.18248546
45SGK31.17864011
46PHKG11.15280927
47PHKG21.15280927
48JAK31.13238006
49UHMK11.10313604
50BTK1.09129492
51KSR21.08920821
52MINK11.08544864
53INSRR1.05587789
54TNIK1.05119184
55MARK11.04301904
56PTK61.04152683
57TBK11.03757541
58MAP3K61.01726241
59MAPK151.01438974
60LMTK20.99840252
61CSK0.99095983
62MTOR0.98182064
63CAMK10.97636582
64PNCK0.94809123
65GRK60.94758491
66CDK50.92732029
67ERBB20.92504120
68IRAK40.90118766
69ALK0.90040050
70FGFR40.87900694
71MAPK70.87423170
72RET0.87229200
73PRKD20.87022111
74CAMK40.85849425
75EPHB10.84945468
76MAP3K10.83991503
77PRPF4B0.83863534
78MAP2K40.81455276
79ITK0.80882731
80JAK10.80725717
81STK110.80713523
82PKN20.80235620
83RIPK40.80120921
84DDR20.77741866
85RPS6KA20.76829548
86PDGFRB0.76556593
87IKBKE0.76360277
88EPHB20.75998658
89PTK20.75844404
90MAPK110.74474342
91SYK0.74372449
92SGK20.73119531
93MAP3K30.71545582
94FGFR30.70269545
95RPS6KC10.68233286
96RPS6KL10.68233286
97SGK10.68051679
98SGK4940.67624230
99SGK2230.67624230
100KIT0.66867103
101PRKD10.66323116
102FES0.65945548
103CSF1R0.65191470
104CDK40.63957384
105LCK0.63472098
106PRKAA10.61673530
107JAK20.60499168
108BMX0.60464157
109MAP2K60.59538187
110FYN0.59067131
111PAK30.58966142
112MAP3K110.58611989
113HIPK20.56731125
114RPS6KA30.56207079
115MAPK100.55532173
116DAPK10.54822764
117DYRK1B0.53815836
118MST1R0.53216209
119PRKAA20.52205594
120RPS6KA60.52176864
121PDPK10.51797533
122DYRK1A0.50763019
123CAMKK20.50284284
124PDK10.49989557
125MAP2K20.49356052
126FGFR10.48944731
127LATS10.48864201
128MAPK80.48560704
129HCK0.47279372
130SRC0.46260442
131MAP3K20.45791413
132MAPK120.44908528
133CDK60.44212077
134FGR0.42075417
135LYN0.41685982
136PRKCZ0.40898544
137CHUK0.40524759
138PTK2B0.39760496
139IRAK30.39693853
140MARK30.38723439
141TNK20.38217435
142EPHA30.38103576
143PASK0.37742169
144TAOK20.36937841
145MAPK30.36092349

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.24592671
2Acute myeloid leukemia_Homo sapiens_hsa052211.96475446
3Circadian entrainment_Homo sapiens_hsa047131.91180505
4Nicotine addiction_Homo sapiens_hsa050331.89477102
5Nitrogen metabolism_Homo sapiens_hsa009101.85870677
6Glutamatergic synapse_Homo sapiens_hsa047241.81783875
7Aldosterone synthesis and secretion_Homo sapiens_hsa049251.76398985
8Osteoclast differentiation_Homo sapiens_hsa043801.70673753
9GABAergic synapse_Homo sapiens_hsa047271.70170717
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.69879444
11Long-term potentiation_Homo sapiens_hsa047201.68689450
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.68301982
13Type II diabetes mellitus_Homo sapiens_hsa049301.68255167
14Salivary secretion_Homo sapiens_hsa049701.66558379
15Olfactory transduction_Homo sapiens_hsa047401.64751260
16Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.64490025
17Insulin secretion_Homo sapiens_hsa049111.63288612
18Gastric acid secretion_Homo sapiens_hsa049711.60024407
19Morphine addiction_Homo sapiens_hsa050321.57741156
20Synaptic vesicle cycle_Homo sapiens_hsa047211.54496489
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.52824286
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.51242276
23Leishmaniasis_Homo sapiens_hsa051401.50696555
24Lysine degradation_Homo sapiens_hsa003101.48680757
25Phosphatidylinositol signaling system_Homo sapiens_hsa040701.41978961
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.40904982
27Dorso-ventral axis formation_Homo sapiens_hsa043201.32119046
28Amphetamine addiction_Homo sapiens_hsa050311.31408170
29Cholinergic synapse_Homo sapiens_hsa047251.31121777
30Dopaminergic synapse_Homo sapiens_hsa047281.30539326
31Oxytocin signaling pathway_Homo sapiens_hsa049211.30342632
32Primary immunodeficiency_Homo sapiens_hsa053401.27005006
33Toxoplasmosis_Homo sapiens_hsa051451.22829020
34Renin secretion_Homo sapiens_hsa049241.20691658
35Thyroid hormone signaling pathway_Homo sapiens_hsa049191.20582955
36GnRH signaling pathway_Homo sapiens_hsa049121.19686205
37cAMP signaling pathway_Homo sapiens_hsa040241.19038584
38Carbohydrate digestion and absorption_Homo sapiens_hsa049731.17017328
39mTOR signaling pathway_Homo sapiens_hsa041501.16856550
40Influenza A_Homo sapiens_hsa051641.15256951
41Cocaine addiction_Homo sapiens_hsa050301.14844721
42Allograft rejection_Homo sapiens_hsa053301.14567068
43Dilated cardiomyopathy_Homo sapiens_hsa054141.14549135
44Toll-like receptor signaling pathway_Homo sapiens_hsa046201.13723688
45Calcium signaling pathway_Homo sapiens_hsa040201.12857544
46NF-kappa B signaling pathway_Homo sapiens_hsa040641.12065266
47Graft-versus-host disease_Homo sapiens_hsa053321.11841124
48Staphylococcus aureus infection_Homo sapiens_hsa051501.11110321
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.09629042
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.08969532
51Phospholipase D signaling pathway_Homo sapiens_hsa040721.08737845
52TNF signaling pathway_Homo sapiens_hsa046681.08496681
53Autoimmune thyroid disease_Homo sapiens_hsa053201.08095278
54Glioma_Homo sapiens_hsa052141.07371627
55Estrogen signaling pathway_Homo sapiens_hsa049151.06739647
56cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06635918
57Pancreatic secretion_Homo sapiens_hsa049721.04788847
58Notch signaling pathway_Homo sapiens_hsa043301.04686851
59Leukocyte transendothelial migration_Homo sapiens_hsa046701.04489109
60ErbB signaling pathway_Homo sapiens_hsa040121.02467246
61Long-term depression_Homo sapiens_hsa047301.02044118
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.01818534
63Hepatitis B_Homo sapiens_hsa051611.01658126
64Tuberculosis_Homo sapiens_hsa051521.00439081
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.97910042
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.96860937
67Viral myocarditis_Homo sapiens_hsa054160.96388766
68Hepatitis C_Homo sapiens_hsa051600.96359518
69Axon guidance_Homo sapiens_hsa043600.95831263
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95713229
71Taste transduction_Homo sapiens_hsa047420.95186507
72Measles_Homo sapiens_hsa051620.94846235
73Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.94140075
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94094713
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.93944705
76Choline metabolism in cancer_Homo sapiens_hsa052310.93507354
77Bile secretion_Homo sapiens_hsa049760.90789184
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.90197629
79Herpes simplex infection_Homo sapiens_hsa051680.89153750
80Gap junction_Homo sapiens_hsa045400.89104824
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.88889681
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88324204
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88240537
84Inositol phosphate metabolism_Homo sapiens_hsa005620.88214677
85Insulin resistance_Homo sapiens_hsa049310.88016936
86VEGF signaling pathway_Homo sapiens_hsa043700.87500519
87Thyroid hormone synthesis_Homo sapiens_hsa049180.85175563
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.84927616
89Fatty acid biosynthesis_Homo sapiens_hsa000610.84589661
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84476318
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84279518
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83841430
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83416539
94Melanogenesis_Homo sapiens_hsa049160.82700596
95Circadian rhythm_Homo sapiens_hsa047100.82664057
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.81486481
97Non-small cell lung cancer_Homo sapiens_hsa052230.80560809
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.80385236
99Prostate cancer_Homo sapiens_hsa052150.80197112
100Endometrial cancer_Homo sapiens_hsa052130.79952637
101Chronic myeloid leukemia_Homo sapiens_hsa052200.78357226
102Insulin signaling pathway_Homo sapiens_hsa049100.78192274
103MAPK signaling pathway_Homo sapiens_hsa040100.77856236
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.77358087
105Phototransduction_Homo sapiens_hsa047440.76231880
106Proteoglycans in cancer_Homo sapiens_hsa052050.75776985
107HTLV-I infection_Homo sapiens_hsa051660.74953140
108Amoebiasis_Homo sapiens_hsa051460.74781561
109FoxO signaling pathway_Homo sapiens_hsa040680.74164532
110Glucagon signaling pathway_Homo sapiens_hsa049220.73683456
111Malaria_Homo sapiens_hsa051440.72004311
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71892112
113Renal cell carcinoma_Homo sapiens_hsa052110.71768032
114Type I diabetes mellitus_Homo sapiens_hsa049400.71659157
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.71430175
116Rap1 signaling pathway_Homo sapiens_hsa040150.70371872
117Apoptosis_Homo sapiens_hsa042100.69669705
118Prion diseases_Homo sapiens_hsa050200.68888720
119NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68484537
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.67798910
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.66905998
122Cyanoamino acid metabolism_Homo sapiens_hsa004600.66682888
123Basal cell carcinoma_Homo sapiens_hsa052170.66053969
124Antigen processing and presentation_Homo sapiens_hsa046120.65740497
125B cell receptor signaling pathway_Homo sapiens_hsa046620.65635237
126AMPK signaling pathway_Homo sapiens_hsa041520.65367270
127HIF-1 signaling pathway_Homo sapiens_hsa040660.64922041
128Hematopoietic cell lineage_Homo sapiens_hsa046400.64617102
129Bladder cancer_Homo sapiens_hsa052190.62336182
130Pertussis_Homo sapiens_hsa051330.62146962
131Small cell lung cancer_Homo sapiens_hsa052220.61235579
132Serotonergic synapse_Homo sapiens_hsa047260.61200348
133Endocytosis_Homo sapiens_hsa041440.59320950
134MicroRNAs in cancer_Homo sapiens_hsa052060.59007585
135Chemokine signaling pathway_Homo sapiens_hsa040620.58441893
136T cell receptor signaling pathway_Homo sapiens_hsa046600.58043450
137Focal adhesion_Homo sapiens_hsa045100.57565950
138Wnt signaling pathway_Homo sapiens_hsa043100.55806392
139Central carbon metabolism in cancer_Homo sapiens_hsa052300.54001469
140Platelet activation_Homo sapiens_hsa046110.52705964
141AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51609766
142Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50539767
143Pancreatic cancer_Homo sapiens_hsa052120.48928110
144Ras signaling pathway_Homo sapiens_hsa040140.48771211
145ABC transporters_Homo sapiens_hsa020100.48566506
146Colorectal cancer_Homo sapiens_hsa052100.47547863
147Prolactin signaling pathway_Homo sapiens_hsa049170.47102943
148Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46997424
149Hedgehog signaling pathway_Homo sapiens_hsa043400.46563804

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