LEP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1triglyceride catabolic process (GO:0019433)8.81302020
2regulation of sequestering of triglyceride (GO:0010889)8.17342923
3neutral lipid catabolic process (GO:0046461)7.93755375
4acylglycerol catabolic process (GO:0046464)7.93755375
5white fat cell differentiation (GO:0050872)7.46997368
6brown fat cell differentiation (GO:0050873)6.88150790
7lipid particle organization (GO:0034389)6.45021536
8valine metabolic process (GO:0006573)6.30396625
9positive regulation of fatty acid beta-oxidation (GO:0032000)6.29037569
10regulation of cholesterol storage (GO:0010885)6.13479365
11glycerolipid catabolic process (GO:0046503)5.96043218
12triglyceride biosynthetic process (GO:0019432)5.92573851
13biotin metabolic process (GO:0006768)5.82776519
14positive regulation of fatty acid oxidation (GO:0046321)5.81653909
15neutral lipid biosynthetic process (GO:0046460)5.68399933
16acylglycerol biosynthetic process (GO:0046463)5.68399933
17fatty acid transmembrane transport (GO:1902001)5.67234692
18lipid storage (GO:0019915)5.44900262
19negative regulation of macrophage derived foam cell differentiation (GO:0010745)5.31078729
20polyol transport (GO:0015791)4.81466924
21triglyceride metabolic process (GO:0006641)4.78011146
22regulation of fatty acid beta-oxidation (GO:0031998)4.70894833
23plasma lipoprotein particle clearance (GO:0034381)4.65542957
24fatty acid homeostasis (GO:0055089)4.59212132
25protein heterotrimerization (GO:0070208)4.57489240
26acylglycerol metabolic process (GO:0006639)4.53109086
27* fatty acid beta-oxidation (GO:0006635)4.52961755
28long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.52116648
29carnitine shuttle (GO:0006853)4.50697711
30neutral lipid metabolic process (GO:0006638)4.47122603
31fatty-acyl-CoA metabolic process (GO:0035337)4.46728971
32negative regulation of protein autophosphorylation (GO:0031953)4.39342360
33ethanol oxidation (GO:0006069)4.38541015
34alpha-linolenic acid metabolic process (GO:0036109)4.37549874
35fatty-acyl-CoA biosynthetic process (GO:0046949)4.26969946
36regulation of cAMP-dependent protein kinase activity (GO:2000479)4.26213793
37regulation of fatty acid oxidation (GO:0046320)4.24761758
38long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.24722137
39positive regulation of lipid catabolic process (GO:0050996)4.23774008
40regulation of macrophage derived foam cell differentiation (GO:0010743)4.20875143
41positive regulation of fatty acid metabolic process (GO:0045923)4.17389281
42negative regulation of smooth muscle cell migration (GO:0014912)4.15791031
43positive regulation of triglyceride lipase activity (GO:0061365)4.13611729
44positive regulation of lipoprotein lipase activity (GO:0051006)4.13611729
45branched-chain amino acid metabolic process (GO:0009081)4.11569592
46L-serine transport (GO:0015825)4.10227078
47thioester biosynthetic process (GO:0035384)4.08932164
48acyl-CoA biosynthetic process (GO:0071616)4.08932164
49negative regulation of phagocytosis (GO:0050765)4.06526855
50positive regulation of lipid storage (GO:0010884)4.04943480
51positive regulation of glucose import (GO:0046326)4.03665412
52* fatty acid oxidation (GO:0019395)4.02270440
53negative regulation of metanephros development (GO:0072217)4.01236951
54negative regulation of granulocyte differentiation (GO:0030853)3.98880721
55regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)3.98640079
56positive regulation of glycolytic process (GO:0045821)3.97675491
57retina vasculature morphogenesis in camera-type eye (GO:0061299)3.96448708
58diacylglycerol metabolic process (GO:0046339)3.96021219
59* lipid oxidation (GO:0034440)3.94645427
60* fatty acid catabolic process (GO:0009062)3.89847202
61primary alcohol metabolic process (GO:0034308)3.84027044
62response to phenylpropanoid (GO:0080184)3.83491724
63negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.83459151
64positive regulation of glomerulus development (GO:0090193)3.83420678
65cellular response to lithium ion (GO:0071285)3.78651615
66coenzyme A biosynthetic process (GO:0015937)3.78559741
67cGMP-mediated signaling (GO:0019934)3.78410497
68pentose-phosphate shunt (GO:0006098)3.76953537
69positive regulation of cholesterol efflux (GO:0010875)3.75939971
70branched-chain amino acid catabolic process (GO:0009083)3.75835654
71carnitine transmembrane transport (GO:1902603)3.74399002
72growth hormone receptor signaling pathway (GO:0060396)3.73892715
73response to epinephrine (GO:0071871)3.71758397
74negative regulation of DNA biosynthetic process (GO:2000279)3.71360038
75NADPH regeneration (GO:0006740)3.70025600
76retinol metabolic process (GO:0042572)3.69442537
77regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.68774867
78positive regulation of cholesterol transport (GO:0032376)3.66485571
79positive regulation of sterol transport (GO:0032373)3.66485571
80protein localization to cell surface (GO:0034394)3.65496661
81regulation of glycogen (starch) synthase activity (GO:2000465)3.64668805
82endocrine hormone secretion (GO:0060986)3.63233956
83negative regulation of lipid storage (GO:0010888)3.63001553
84CDP-diacylglycerol biosynthetic process (GO:0016024)3.61755561
85oxaloacetate metabolic process (GO:0006107)3.61063885
86regulation of receptor binding (GO:1900120)3.55513533
87serine transport (GO:0032329)3.53937208
88alanine transport (GO:0032328)3.53685800
89barbed-end actin filament capping (GO:0051016)3.51101882
90keratan sulfate catabolic process (GO:0042340)3.50990098
91phosphatidic acid biosynthetic process (GO:0006654)3.50544398
92phosphatidic acid metabolic process (GO:0046473)3.50544398
93triglyceride homeostasis (GO:0070328)3.50455728
94acylglycerol homeostasis (GO:0055090)3.50455728
95cellular response to epinephrine stimulus (GO:0071872)3.49555104
96negative regulation of macrophage differentiation (GO:0045650)3.48182960
97angiogenesis involved in wound healing (GO:0060055)3.45092186
98positive regulation of metanephros development (GO:0072216)3.44542436
99tricarboxylic acid metabolic process (GO:0072350)3.44048299
100amino-acid betaine transport (GO:0015838)3.43540246
101carnitine transport (GO:0015879)3.43540246
102positive regulation of macrophage cytokine production (GO:0060907)3.42857840
103positive regulation of endothelial cell apoptotic process (GO:2000353)3.42844391
104negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.41033796
105positive regulation of glucose transport (GO:0010828)3.39577743
106transcytosis (GO:0045056)3.39008161
107glomerular filtration (GO:0003094)3.38733278
108acetyl-CoA metabolic process (GO:0006084)3.38531922
109regulation of lipid storage (GO:0010883)3.37884358
110regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.33690005
111regulation of glomerulus development (GO:0090192)3.33380931
112regulation of triglyceride catabolic process (GO:0010896)3.32482442
113renal filtration (GO:0097205)3.31324877
114phagocytosis, recognition (GO:0006910)3.30548946
115regulation of macrophage chemotaxis (GO:0010758)3.30113195
116endothelium development (GO:0003158)3.29759014
117import into cell (GO:0098657)3.29118288
118NADH metabolic process (GO:0006734)3.29100036
119ethanol metabolic process (GO:0006067)3.27305526
120negative regulation of smooth muscle cell proliferation (GO:0048662)3.27247886
121long-chain fatty acid transport (GO:0015909)3.26633836
122negative regulation of gluconeogenesis (GO:0045721)3.25721046
123CDP-diacylglycerol metabolic process (GO:0046341)3.25174269
124fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.24685348
125regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.24597228
126response to hydroperoxide (GO:0033194)3.22713880
127cellular response to growth hormone stimulus (GO:0071378)3.22066230
128polyketide metabolic process (GO:0030638)3.20759893
129doxorubicin metabolic process (GO:0044598)3.20759893
130daunorubicin metabolic process (GO:0044597)3.20759893
131apoptotic cell clearance (GO:0043277)3.19959542
132positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.19148757
133regulation of protein kinase A signaling (GO:0010738)3.12795646
134negative regulation of lipid catabolic process (GO:0050995)3.11122520
135endothelial cell morphogenesis (GO:0001886)3.10071694
136extracellular fibril organization (GO:0043206)3.08379252
137lipoprotein transport (GO:0042953)3.03753401
138primary alcohol catabolic process (GO:0034310)2.97837814
139regulation of lipid catabolic process (GO:0050994)2.93401051
140low-density lipoprotein particle clearance (GO:0034383)10.8821150

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse6.42670166
2CLOCK_20551151_ChIP-Seq_293T_Human4.76600513
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.72337017
4RXR_22158963_ChIP-Seq_LIVER_Mouse2.71462551
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.69915835
6LXR_22158963_ChIP-Seq_LIVER_Mouse2.64510377
7* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse2.53686114
8GATA1_22025678_ChIP-Seq_K562_Human2.43390114
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.29503221
10PPARG_20887899_ChIP-Seq_3T3-L1_Mouse2.12903155
11* PPARG_19300518_ChIP-PET_3T3-L1_Mouse14.3748407
12TP63_17297297_ChIP-ChIP_HaCaT_Human1.96771950
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.91163479
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.91131870
15RARG_19884340_ChIP-ChIP_MEFs_Mouse1.89219042
16CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.86674525
17* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.81031975
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.75314552
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.73419472
20PPAR_26484153_Chip-Seq_NCI-H1993_Human1.72341563
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.55378811
22TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55059334
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.49528819
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43254401
25* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.43057637
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.32356325
27* FOXO3_23340844_ChIP-Seq_DLD1_Human1.30541942
28HIF1A_21447827_ChIP-Seq_MCF-7_Human1.30195165
29GATA2_21666600_ChIP-Seq_HMVEC_Human1.29953235
30SA1_22415368_ChIP-Seq_MEFs_Mouse1.28553896
31TBX20_22080862_ChIP-Seq_HEART_Mouse1.27323404
32TBX20_22328084_ChIP-Seq_HEART_Mouse1.27323404
33VDR_24787735_ChIP-Seq_THP-1_Human1.26359600
34RAD21_21589869_ChIP-Seq_MESCs_Mouse1.23139381
35GATA1_19941826_ChIP-Seq_K562_Human1.18187054
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17453687
37Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.16976110
38ZNF263_19887448_ChIP-Seq_K562_Human1.15375170
39EZH2_27304074_Chip-Seq_ESCs_Mouse1.14791505
40EP300_21415370_ChIP-Seq_HL-1_Mouse1.14487160
41SOX9_24532713_ChIP-Seq_HFSC_Mouse1.14443326
42PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.13745796
43ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13399430
44* CJUN_26792858_Chip-Seq_BT549_Human1.13178644
45DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11746049
46JARID2_20075857_ChIP-Seq_MESCs_Mouse1.11589197
47ESR2_21235772_ChIP-Seq_MCF-7_Human1.10648872
48CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09670425
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09656181
50SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.08683687
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07150636
52KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04829531
53SMC3_22415368_ChIP-Seq_MEFs_Mouse1.01317871
54P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00694592
55TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00597984
56RXR_22108803_ChIP-Seq_LS180_Human1.00117994
57ELK4_26923725_Chip-Seq_MESODERM_Mouse0.99981575
58SMC1_22415368_ChIP-Seq_MEFs_Mouse0.98756771
59SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97874319
60BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.97562116
61ESR1_20079471_ChIP-ChIP_T-47D_Human0.96115556
62EZH2_18974828_ChIP-Seq_MESCs_Mouse0.95385310
63RNF2_18974828_ChIP-Seq_MESCs_Mouse0.95385310
64CBP_21632823_ChIP-Seq_H3396_Human0.95313831
65EGR1_23403033_ChIP-Seq_LIVER_Mouse0.94960020
66TP53_20018659_ChIP-ChIP_R1E_Mouse0.94654994
67STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94458638
68TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.94089565
69CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93758417
70RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93594820
71FOXA2_19822575_ChIP-Seq_HepG2_Human0.93567868
72SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.91605452
73PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89724383
74* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89632636
75IRF8_22096565_ChIP-ChIP_GC-B_Human0.86186396
76NFIB_24661679_ChIP-Seq_LUNG_Mouse0.84262421
77RNF2_27304074_Chip-Seq_ESCs_Mouse0.83863261
78GATA2_19941826_ChIP-Seq_K562_Human0.83269433
79SALL1_21062744_ChIP-ChIP_HESCs_Human0.82507726
80NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.82501157
81NRF2_20460467_ChIP-Seq_MEFs_Mouse0.82501157
82SOX2_20726797_ChIP-Seq_SW620_Human0.82153448
83CTCF_27219007_Chip-Seq_Bcells_Human0.82088904
84PIAS1_25552417_ChIP-Seq_VCAP_Human0.82026128
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.81758386
86ERG_21242973_ChIP-ChIP_JURKAT_Human0.81661850
87WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.81257296
88MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.80690832
89GBX2_23144817_ChIP-Seq_PC3_Human0.80357178
90MYB_21317192_ChIP-Seq_ERMYB_Mouse0.78769037
91ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.78416611
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.77370834
93GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.76333045
94FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.74776228
95SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.74645795
96CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.74131693
97* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.74038486
98BCAT_22108803_ChIP-Seq_LS180_Human0.74025811
99EZH2_27294783_Chip-Seq_ESCs_Mouse0.73717565
100RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.73314520
101SOX11_22085726_ChIP-Seq_ESNs_Mouse0.72751683
102ELK3_25401928_ChIP-Seq_HUVEC_Human0.71871737
103TCF4_18268006_ChIP-ChIP_LS174T_Human0.71696350
104SMAD_19615063_ChIP-ChIP_OVARY_Human0.71696136
105EZH2_22144423_ChIP-Seq_EOC_Human0.70260597
106IKZF1_21737484_ChIP-ChIP_HCT116_Human0.69507339
107JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.69035724
108KDM2B_26808549_Chip-Seq_K562_Human0.68416808
109KDM2B_26808549_Chip-Seq_SUP-B15_Human0.68215717
110PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.68103398
111RUNX_20019798_ChIP-Seq_JUKART_Human0.67911434
112LXR_22292898_ChIP-Seq_THP-1_Human0.67766005
113ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.67706770
114DROSHA_22980978_ChIP-Seq_HELA_Human0.67402740
115WT1_25993318_ChIP-Seq_PODOCYTE_Human0.67211832
116GATA3_24758297_ChIP-Seq_MCF-7_Human0.67051829
117KLF4_19829295_ChIP-Seq_ESCs_Human0.66597783
118ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.65751915
119MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.65445255
120PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.64932613
121SMC4_20622854_ChIP-Seq_HELA_Human0.64750031
122SALL4_18804426_ChIP-ChIP_XEN_Mouse0.64734021
123NR3C1_23031785_ChIP-Seq_PC12_Mouse0.64336499
124* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.64191729
125SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.64184639
126* TET1_21490601_ChIP-Seq_MESCs_Mouse0.64065257
127* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63373605
128* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.63302598
129ESR1_21235772_ChIP-Seq_MCF-7_Human0.63210429
130MYC_27129775_Chip-Seq_CORNEA_Mouse0.63167382
131* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.62812922
132AHR_22903824_ChIP-Seq_MCF-7_Human0.62497122
133EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.61348522
134MTF2_20144788_ChIP-Seq_MESCs_Mouse0.60868065
135ZNF217_24962896_ChIP-Seq_MCF-7_Human0.60612806
136SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.59896887

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose8.43278785
2MP0005666_abnormal_adipose_tissue5.68341577
3MP0004130_abnormal_muscle_cell5.07070555
4MP0008438_abnormal_cutaneous_collagen4.98892758
5MP0004185_abnormal_adipocyte_glucose4.71105212
6* MP0005375_adipose_tissue_phenotype4.00991784
7MP0000013_abnormal_adipose_tissue3.92423212
8MP0003191_abnormal_cellular_cholesterol3.25865678
9MP0002837_dystrophic_cardiac_calcinosis3.25091551
10MP0005275_abnormal_skin_tensile3.20217493
11MP0002971_abnormal_brown_adipose3.05165659
12MP0005503_abnormal_tendon_morphology3.01754698
13* MP0010329_abnormal_lipoprotein_level2.70189656
14MP0005334_abnormal_fat_pad2.55319548
15* MP0009115_abnormal_fat_cell2.55204153
16MP0003705_abnormal_hypodermis_morpholog2.30341367
17* MP0000003_abnormal_adipose_tissue2.29880385
18MP0004272_abnormal_basement_membrane2.02902036
19* MP0002970_abnormal_white_adipose2.02716514
20* MP0002118_abnormal_lipid_homeostasis1.99343813
21MP0005535_abnormal_body_temperature1.98393801
22* MP0002876_abnormal_thyroid_physiology1.91242538
23MP0001661_extended_life_span1.91168696
24MP0003868_abnormal_feces_composition1.79392115
25MP0003724_increased_susceptibility_to1.67441755
26MP0005448_abnormal_energy_balance1.55010398
27* MP0003959_abnormal_lean_body1.43363071
28MP0005365_abnormal_bile_salt1.35886145
29* MP0003690_abnormal_glial_cell1.32601060
30MP0009780_abnormal_chondrocyte_physiolo1.31431028
31MP0004147_increased_porphyrin_level1.30541062
32MP0002933_joint_inflammation1.30401846
33MP0000751_myopathy1.28797971
34* MP0005452_abnormal_adipose_tissue1.28717226
35MP0001727_abnormal_embryo_implantation1.28626530
36MP0003828_pulmonary_edema1.23922060
37* MP0000609_abnormal_liver_physiology1.23897675
38MP0002078_abnormal_glucose_homeostasis1.22967267
39MP0001881_abnormal_mammary_gland1.20857049
40* MP0002108_abnormal_muscle_morphology1.20073013
41MP0002254_reproductive_system_inflammat1.19749208
42MP0003950_abnormal_plasma_membrane1.17602525
43MP0002166_altered_tumor_susceptibility1.15211688
44MP0006138_congestive_heart_failure1.14013691
45MP0002060_abnormal_skin_morphology1.12743652
46MP0002796_impaired_skin_barrier1.12591870
47MP0002638_abnormal_pupillary_reflex1.12172694
48MP0010368_abnormal_lymphatic_system1.12158294
49MP0003566_abnormal_cell_adhesion1.10386514
50MP0000750_abnormal_muscle_regeneration1.07306222
51MP0002139_abnormal_hepatobiliary_system1.06952066
52MP0003045_fibrosis1.06817535
53MP0000343_altered_response_to1.02400649
54MP0008775_abnormal_heart_ventricle0.99586715
55MP0001756_abnormal_urination0.96647727
56* MP0003186_abnormal_redox_activity0.93853653
57MP0000767_abnormal_smooth_muscle0.92083124
58MP0008961_abnormal_basal_metabolism0.82589541
59MP0005058_abnormal_lysosome_morphology0.82577568
60MP0002006_tumorigenesis0.82062627
61MP0005584_abnormal_enzyme/coenzyme_acti0.80480520
62MP0002168_other_aberrant_phenotype0.78707546
63MP0005164_abnormal_response_to0.78049026
64MP0002332_abnormal_exercise_endurance0.76216381
65MP0001879_abnormal_lymphatic_vessel0.75980305
66MP0002295_abnormal_pulmonary_circulatio0.74215928
67MP0001177_atelectasis0.73870713
68MP0005508_abnormal_skeleton_morphology0.73360242
69MP0005319_abnormal_enzyme/_coenzyme0.72727642
70MP0005360_urolithiasis0.72277625
71* MP0005620_abnormal_muscle_contractility0.71570892
72* MP0000759_abnormal_skeletal_muscle0.70322540
73MP0001958_emphysema0.69860814
74* MP0001544_abnormal_cardiovascular_syste0.69841019
75* MP0005385_cardiovascular_system_phenoty0.69841019
76MP0005167_abnormal_blood-brain_barrier0.68925971
77* MP0004087_abnormal_muscle_fiber0.66534145
78* MP0003948_abnormal_gas_homeostasis0.66289680
79* MP0003953_abnormal_hormone_level0.66143104
80MP0000749_muscle_degeneration0.65474255
81MP0001533_abnormal_skeleton_physiology0.65177298
82MP0004084_abnormal_cardiac_muscle0.63310860
83MP0000427_abnormal_hair_cycle0.62526372
84MP0005388_respiratory_system_phenotype0.62305380
85MP0002133_abnormal_respiratory_system0.62305380
86MP0009763_increased_sensitivity_to0.61915050
87MP0001944_abnormal_pancreas_morphology0.61376453
88MP0002998_abnormal_bone_remodeling0.61167543
89MP0009672_abnormal_birth_weight0.60986053
90MP0002972_abnormal_cardiac_muscle0.59218947
91MP0005165_increased_susceptibility_to0.59175287
92MP0000249_abnormal_blood_vessel0.58492273
93* MP0009643_abnormal_urine_homeostasis0.57743451
94MP0000230_abnormal_systemic_arterial0.55825078
95MP0004019_abnormal_vitamin_homeostasis0.54696192
96MP0001542_abnormal_bone_strength0.53929474
97MP0005645_abnormal_hypothalamus_physiol0.51620730
98MP0000747_muscle_weakness0.51255058
99MP0003448_altered_tumor_morphology0.50301140
100MP0005390_skeleton_phenotype0.50190713
101MP0003646_muscle_fatigue0.49758930
102MP0005595_abnormal_vascular_smooth0.48963802
103MP0005084_abnormal_gallbladder_morpholo0.48911782
104MP0002128_abnormal_blood_circulation0.48728035
105MP0005332_abnormal_amino_acid0.48506736
106MP0003075_altered_response_to0.48329950
107MP0005023_abnormal_wound_healing0.47857447
108MP0003279_aneurysm0.46331135
109* MP0006036_abnormal_mitochondrial_physio0.45773704
110MP0000604_amyloidosis0.45537397
111MP0004858_abnormal_nervous_system0.45236645
112MP0002090_abnormal_vision0.45192434
113MP0003011_delayed_dark_adaptation0.44884663
114* MP0001614_abnormal_blood_vessel0.44102518
115MP0005647_abnormal_sex_gland0.43992109
116MP0004883_abnormal_blood_vessel0.43336826
117MP0004782_abnormal_surfactant_physiolog0.43073881
118MP0003091_abnormal_cell_migration0.43056312
119MP0005330_cardiomyopathy0.43038832
120* MP0001501_abnormal_sleep_pattern0.43002146
121MP0001851_eye_inflammation0.41799342
122MP0001545_abnormal_hematopoietic_system0.41682685
123MP0005397_hematopoietic_system_phenotyp0.41682685
124MP0002136_abnormal_kidney_physiology0.41606806
125MP0003221_abnormal_cardiomyocyte_apopto0.41069999
126MP0005376_homeostasis/metabolism_phenot0.40854134
127MP0002069_abnormal_eating/drinking_beha0.39362482
128MP0005501_abnormal_skin_physiology0.38322292

Predicted human phenotypes

RankGene SetZ-score
1Oligomenorrhea (HP:0000876)8.62845774
2Acanthosis nigricans (HP:0000956)7.73316845
3Hypertriglyceridemia (HP:0002155)6.70971634
4Hyperglycinuria (HP:0003108)5.34556963
5Abnormality of glycine metabolism (HP:0010895)4.33317363
6Abnormality of serine family amino acid metabolism (HP:0010894)4.33317363
7Insulin-resistant diabetes mellitus (HP:0000831)4.29907216
8Difficulty running (HP:0009046)4.11145767
9Pigmentary retinal degeneration (HP:0001146)3.96568627
10Increased connective tissue (HP:0009025)3.96303815
11Long foot (HP:0001833)3.92473585
12Complement deficiency (HP:0004431)3.81311063
13Epidermoid cyst (HP:0200040)3.66837725
14Hemorrhage of the eye (HP:0011885)3.66006919
15Insulin resistance (HP:0000855)3.59893136
16Back pain (HP:0003418)3.59099852
17Subcapsular cataract (HP:0000523)3.50019222
18Vertebral compression fractures (HP:0002953)3.42317935
19Abnormality of proline metabolism (HP:0010907)3.41394517
20Hydroxyprolinuria (HP:0003080)3.41394517
21Myoglobinuria (HP:0002913)3.40137123
22Growth hormone excess (HP:0000845)3.39463248
23Myocardial infarction (HP:0001658)3.34567566
24Hyperthyroidism (HP:0000836)3.33140682
25Bone cyst (HP:0012062)3.32017729
26Reduced subcutaneous adipose tissue (HP:0003758)3.26374574
27Thyroid-stimulating hormone excess (HP:0002925)3.18224375
28Multiple enchondromatosis (HP:0005701)3.17439357
29Polycythemia (HP:0001901)3.14358053
30Hyperlipoproteinemia (HP:0010980)3.13804568
31Abnormality of fatty-acid metabolism (HP:0004359)3.11205421
32Ectopia lentis (HP:0001083)3.08367021
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.05743203
34Hypoalphalipoproteinemia (HP:0003233)3.04297890
35Increased variability in muscle fiber diameter (HP:0003557)3.03403009
36Cerebral aneurysm (HP:0004944)3.01797931
37Large hands (HP:0001176)2.96696633
38Cervical subluxation (HP:0003308)2.96478864
39Ankle contracture (HP:0006466)2.92235857
40Hyperpituitarism (HP:0010514)2.87298468
41Xanthomatosis (HP:0000991)2.85658858
42Colitis (HP:0002583)2.85596294
43Broad metatarsal (HP:0001783)2.83509951
44Frequent falls (HP:0002359)2.83428730
45Skin nodule (HP:0200036)2.80139145
46Ketoacidosis (HP:0001993)2.77176757
47Hypoglycemic coma (HP:0001325)2.76835120
48Muscle fiber splitting (HP:0003555)2.72001115
49Abnormality of complement system (HP:0005339)2.71429582
50Spinal rigidity (HP:0003306)2.71206427
51Testicular atrophy (HP:0000029)2.70231249
52Ketosis (HP:0001946)2.69572136
53Type 1 muscle fiber predominance (HP:0003803)2.64197308
54Nausea (HP:0002018)2.59249313
55Rhabdomyolysis (HP:0003201)2.56966079
56Abnormality of skeletal muscle fiber size (HP:0012084)2.54720999
57Facial diplegia (HP:0001349)2.53682333
58Premature rupture of membranes (HP:0001788)2.51940814
59Hypercholesterolemia (HP:0003124)2.49955271
60Increased muscle lipid content (HP:0009058)2.47673920
61Pancreatitis (HP:0001733)2.42692623
62Abnormal cartilage morphology (HP:0002763)2.42074365
63Lipoatrophy (HP:0100578)2.40400558
64Axonal loss (HP:0003447)2.38696111
65Lymphangioma (HP:0100764)2.38361262
66Accelerated skeletal maturation (HP:0005616)2.37920172
67Autoimmune thrombocytopenia (HP:0001973)2.36968884
68Follicular hyperkeratosis (HP:0007502)2.36654117
69Hyperglycinemia (HP:0002154)2.34709423
70Vascular tortuosity (HP:0004948)2.33813363
71Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.33238648
72Tetraparesis (HP:0002273)2.31436432
73Metaphyseal dysplasia (HP:0100255)2.29827392
74Amyloidosis (HP:0011034)2.26125671
75Prenatal maternal abnormality (HP:0002686)2.25019788
76Systemic lupus erythematosus (HP:0002725)2.24657988
77Gonadotropin excess (HP:0000837)2.24471510
78Hyperammonemia (HP:0001987)2.20649042
79Polar cataract (HP:0010696)2.20591239
80Hyporeflexia of lower limbs (HP:0002600)2.19154270
81Proximal amyotrophy (HP:0007126)2.18385773
82Right ventricular cardiomyopathy (HP:0011663)2.16516447
83Resting tremor (HP:0002322)2.16226992
84Decreased subcutaneous fat (HP:0001002)2.15835589
85Abnormality of dicarboxylic acid metabolism (HP:0010995)2.15829372
86Dicarboxylic aciduria (HP:0003215)2.15829372
87Neck muscle weakness (HP:0000467)2.15201632
88Prominent supraorbital ridges (HP:0000336)2.14335748
89Abnormal hemoglobin (HP:0011902)2.13440177
90Pulmonary artery stenosis (HP:0004415)2.12239860
91Slender build (HP:0001533)2.12221531
92Mutism (HP:0002300)2.10866922
93Ileus (HP:0002595)2.09198613
94Gowers sign (HP:0003391)2.05934668
95Venous abnormality (HP:0002624)2.05343649
96Infantile muscular hypotonia (HP:0008947)2.03136038
97Asymmetric septal hypertrophy (HP:0001670)2.01765638
98Abnormality of the lumbar spine (HP:0100712)1.99657709
99Rectal prolapse (HP:0002035)1.98967130
100Wormian bones (HP:0002645)1.98066338
101Polyphagia (HP:0002591)1.97799166
102Aortic dissection (HP:0002647)1.95878050
103Cortical dysplasia (HP:0002539)1.95357425
104Shallow orbits (HP:0000586)1.94333839
105Myotonia (HP:0002486)1.93895339
106Abnormality of subcutaneous fat tissue (HP:0001001)1.93402234
107Prolonged bleeding time (HP:0003010)1.91497884
108Dilatation of the ascending aorta (HP:0005111)1.91209215
109Turricephaly (HP:0000262)1.90098533
110Esophageal varix (HP:0002040)1.88977992
111Megalocornea (HP:0000485)1.88814425
112Fused cervical vertebrae (HP:0002949)1.85737094
113Aortic aneurysm (HP:0004942)1.85108792
114Polygenic inheritance (HP:0010982)1.84966946
115Muscle stiffness (HP:0003552)1.84394821
116Adactyly (HP:0009776)1.83760834
117Atrioventricular block (HP:0001678)1.83309085
118Hyperglycemia (HP:0003074)1.83257105
119Abnormal glucose tolerance (HP:0001952)1.82986100
120Aortic valve stenosis (HP:0001650)1.82781202
121Soft skin (HP:0000977)1.82602386
122Striae distensae (HP:0001065)1.82460533
123Hypercortisolism (HP:0001578)1.82111900
124Corneal dystrophy (HP:0001131)1.81406021
125Joint hemorrhage (HP:0005261)1.80439399
126Mitral valve prolapse (HP:0001634)1.80389978
127Toxemia of pregnancy (HP:0100603)1.78661812
128Glucose intolerance (HP:0000833)1.78265947
129Protrusio acetabuli (HP:0003179)1.77783093
130Coxa vara (HP:0002812)1.75045831
131Arterial tortuosity (HP:0005116)1.72861432
132Abnormality of the periventricular white matter (HP:0002518)1.72551044
133Spinal cord lesions (HP:0100561)1.71145884
134Syringomyelia (HP:0003396)1.71145884
135Steatorrhea (HP:0002570)1.70536487
136Enlarged penis (HP:0000040)1.68669886
137Coronal craniosynostosis (HP:0004440)1.68662783
138Increased mean platelet volume (HP:0011877)1.67292423
139Joint stiffness (HP:0001387)1.66910388
140* Abnormal eating behavior (HP:0100738)1.66225343
141Foot dorsiflexor weakness (HP:0009027)1.66030894
142Ovoid vertebral bodies (HP:0003300)1.65418260
143Hepatosplenomegaly (HP:0001433)1.65164203
144Easy fatigability (HP:0003388)1.64460795
145Hypercalcemia (HP:0003072)1.63610321

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB36.10670928
2CAMK1D6.08929899
3CAMK1G4.51084448
4SIK14.13423458
5BCKDK3.77667263
6RIPK12.96010131
7LMTK22.72948417
8MST1R2.53030127
9TESK12.50615852
10PDK32.38834350
11PDK42.38834350
12ERN12.04866553
13PRKAA21.92169349
14FGFR31.85393150
15MAP3K131.81774525
16ARAF1.80019065
17INSRR1.71051192
18FGFR21.68073635
19MAPK41.66154249
20PDGFRA1.58486345
21PRKD31.56567900
22RIPK41.46858323
23FRK1.41886620
24ADRBK11.39123727
25PDK21.37182438
26CDK91.34633870
27MOS1.33902519
28TIE11.31990068
29CDK61.31595569
30KIT1.30973326
31EPHB21.23919033
32FES1.20430234
33MAP3K61.19242486
34STK38L1.18626676
35DDR21.13954003
36JAK11.13047716
37IRAK31.12301254
38TGFBR21.12060865
39TTN1.11004761
40MET1.10236360
41KDR1.09136056
42PIK3CA1.08102411
43NEK91.08009299
44MAP2K11.06875538
45PKN11.03262545
46PRKCH1.02985176
47EPHA31.02973034
48PHKG11.00818480
49PHKG21.00818480
50PTK2B0.99072649
51PDPK10.96371430
52LATS10.93194333
53NLK0.92107030
54PRKG10.90869474
55FER0.89680171
56JAK20.88719567
57FGFR40.88108227
58PRKAA10.88076583
59TYK20.84653058
60GRK10.81771459
61MYLK0.78932445
62PDK10.75255076
63IGF1R0.72574917
64MAPK70.72431743
65PDGFRB0.71841889
66MTOR0.71169897
67PRKACG0.69813743
68RET0.69546580
69LATS20.68379219
70CAMKK20.67386090
71CDC42BPA0.67030676
72ILK0.65975572
73PRKG20.63896611
74GSK3A0.62892589
75PAK20.60119845
76MARK10.59171563
77CSK0.58890668
78PRKD10.57886778
79PRKACB0.56206637
80INSR0.55108723
81MAPKAPK50.54868921
82FGFR10.54753993
83DAPK20.54155125
84MAPK30.53464470
85MAP2K30.51592392
86PTK20.48708327
87PINK10.47472191
88CAMK10.47136248
89MAPK110.46249013
90CDK40.46096747
91SRC0.45862378
92DAPK30.45139978
93YES10.44853502
94MAP3K90.43656023
95CSF1R0.43012091
96BMX0.42449968
97MARK20.42161255
98PKN20.41352854
99RPS6KB10.40998001
100ABL20.40884946
101BLK0.40513615
102EPHB10.40429825
103PRKD20.40259437
104TBK10.39910914
105JAK30.38142821
106MAPK120.38054244
107PRKACA0.36930137
108MAP2K40.36535380
109TGFBR10.34355054
110EIF2AK20.34225867
111EEF2K0.34171993
112AKT20.33888623
113MAP3K70.33016729
114TNK20.32869948
115STK30.32380208
116NTRK10.31746776
117PTK60.31099246
118ICK0.30897837
119ABL10.30374354
120CAMKK10.29555664
121MAPK10.26717816
122STK110.25852207
123TRPM70.25600850
124TYRO30.25504837
125LRRK20.25378210
126PAK60.24975844
127PRKCE0.24615001
128CDK50.24154633
129RPS6KA30.23887141
130MAPKAPK30.23072132
131MAP3K30.22421209
132GRK50.22032130
133MAP3K20.21668949
134AKT10.20060319
135SGK30.19647426
136KSR20.19257188
137STK380.18262429

Predicted pathways (KEGG)

RankGene SetZ-score
1Regulation of lipolysis in adipocytes_Homo sapiens_hsa049235.08404618
2PPAR signaling pathway_Homo sapiens_hsa033204.92203161
3Fatty acid biosynthesis_Homo sapiens_hsa000614.49000420
4Propanoate metabolism_Homo sapiens_hsa006404.11069947
5Glycerolipid metabolism_Homo sapiens_hsa005613.39368182
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.29194753
7Fatty acid metabolism_Homo sapiens_hsa012123.27022401
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.01939268
9Fatty acid degradation_Homo sapiens_hsa000712.71494816
10Histidine metabolism_Homo sapiens_hsa003402.52531115
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.27886390
12Fat digestion and absorption_Homo sapiens_hsa049752.08574442
13beta-Alanine metabolism_Homo sapiens_hsa004101.98402052
14Pyruvate metabolism_Homo sapiens_hsa006201.95513260
15* Adipocytokine signaling pathway_Homo sapiens_hsa049201.91430683
16* AMPK signaling pathway_Homo sapiens_hsa041521.85910837
17Caffeine metabolism_Homo sapiens_hsa002321.80135549
18Nitrogen metabolism_Homo sapiens_hsa009101.79313098
19Vitamin B6 metabolism_Homo sapiens_hsa007501.63394680
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.61247271
21Peroxisome_Homo sapiens_hsa041461.60327265
22Carbon metabolism_Homo sapiens_hsa012001.56136012
23Ovarian steroidogenesis_Homo sapiens_hsa049131.52505410
24Phenylalanine metabolism_Homo sapiens_hsa003601.39852633
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.39732104
26Insulin resistance_Homo sapiens_hsa049311.36593365
27Tyrosine metabolism_Homo sapiens_hsa003501.26295477
28Insulin signaling pathway_Homo sapiens_hsa049101.26006533
29Butanoate metabolism_Homo sapiens_hsa006501.21198444
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.14459342
31Staphylococcus aureus infection_Homo sapiens_hsa051501.12711099
32ECM-receptor interaction_Homo sapiens_hsa045121.03240903
33Renin secretion_Homo sapiens_hsa049241.00820796
34Fatty acid elongation_Homo sapiens_hsa000621.00543567
35Retinol metabolism_Homo sapiens_hsa008300.99459051
36Longevity regulating pathway - mammal_Homo sapiens_hsa042110.96334382
37Pentose phosphate pathway_Homo sapiens_hsa000300.93726143
38Glycerophospholipid metabolism_Homo sapiens_hsa005640.92415432
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.87971609
40Glucagon signaling pathway_Homo sapiens_hsa049220.86566547
41Protein digestion and absorption_Homo sapiens_hsa049740.83955189
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.81217334
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81102983
44Type II diabetes mellitus_Homo sapiens_hsa049300.79296321
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78626708
46Tryptophan metabolism_Homo sapiens_hsa003800.77079650
47ABC transporters_Homo sapiens_hsa020100.76377323
48Arginine biosynthesis_Homo sapiens_hsa002200.69384936
49Chemical carcinogenesis_Homo sapiens_hsa052040.68156673
50Focal adhesion_Homo sapiens_hsa045100.64027579
51Glutathione metabolism_Homo sapiens_hsa004800.62438319
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61927533
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60671204
54Dorso-ventral axis formation_Homo sapiens_hsa043200.60648266
55Central carbon metabolism in cancer_Homo sapiens_hsa052300.59058678
56Complement and coagulation cascades_Homo sapiens_hsa046100.58751167
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.57859372
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57220676
59Sulfur relay system_Homo sapiens_hsa041220.56427247
60Autoimmune thyroid disease_Homo sapiens_hsa053200.53023595
61Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51717426
62Vitamin digestion and absorption_Homo sapiens_hsa049770.45799524
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45448765
64Fructose and mannose metabolism_Homo sapiens_hsa000510.44485651
65Lysosome_Homo sapiens_hsa041420.44003293
66cAMP signaling pathway_Homo sapiens_hsa040240.43561989
67mTOR signaling pathway_Homo sapiens_hsa041500.41786129
68Starch and sucrose metabolism_Homo sapiens_hsa005000.41705423
69* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41148596
70Morphine addiction_Homo sapiens_hsa050320.39687843
71HIF-1 signaling pathway_Homo sapiens_hsa040660.35127027
72Biosynthesis of amino acids_Homo sapiens_hsa012300.34973893
73Acute myeloid leukemia_Homo sapiens_hsa052210.34776167
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34199989
75Notch signaling pathway_Homo sapiens_hsa043300.33602145
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33419814
77Arginine and proline metabolism_Homo sapiens_hsa003300.32433601
78Lysine degradation_Homo sapiens_hsa003100.32156236
79Rap1 signaling pathway_Homo sapiens_hsa040150.32139023
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.32022942
81Amoebiasis_Homo sapiens_hsa051460.29820596
82Proteoglycans in cancer_Homo sapiens_hsa052050.29313955
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.27801081
84Linoleic acid metabolism_Homo sapiens_hsa005910.27774965
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.27428349
86Arachidonic acid metabolism_Homo sapiens_hsa005900.25409838
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.25177929
88Ras signaling pathway_Homo sapiens_hsa040140.24761443
89Circadian rhythm_Homo sapiens_hsa047100.24228802
90Platelet activation_Homo sapiens_hsa046110.24149577
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.21951007
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.21199559
93Viral myocarditis_Homo sapiens_hsa054160.21102638
94Salivary secretion_Homo sapiens_hsa049700.20838120
95Small cell lung cancer_Homo sapiens_hsa052220.20746686
96Renin-angiotensin system_Homo sapiens_hsa046140.19699726
97PI3K-Akt signaling pathway_Homo sapiens_hsa041510.19395234
98Thyroid hormone synthesis_Homo sapiens_hsa049180.19285324
99Folate biosynthesis_Homo sapiens_hsa007900.19183280
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.19180974
101Cyanoamino acid metabolism_Homo sapiens_hsa004600.19168095
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.18978757
103Melanogenesis_Homo sapiens_hsa049160.18403055
104Pathways in cancer_Homo sapiens_hsa052000.18060620
105Axon guidance_Homo sapiens_hsa043600.16813292
106* Jak-STAT signaling pathway_Homo sapiens_hsa046300.16755070
107Toxoplasmosis_Homo sapiens_hsa051450.15947271
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.15761434
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.15750347
110Gap junction_Homo sapiens_hsa045400.14787786
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.14014760
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.13365868
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.13062672
114Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.12823257
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.12752184
116Sulfur metabolism_Homo sapiens_hsa009200.12001934
117Malaria_Homo sapiens_hsa051440.11812540
118Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.11680152
119* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.11558439
120Adherens junction_Homo sapiens_hsa045200.10502903
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.09819758
122Prion diseases_Homo sapiens_hsa050200.09648340
123Cocaine addiction_Homo sapiens_hsa050300.09427331
124Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.09136439
125Thyroid cancer_Homo sapiens_hsa052160.08504430
126VEGF signaling pathway_Homo sapiens_hsa043700.08041213
127Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.08007208
128Metabolic pathways_Homo sapiens_hsa011000.07227324
129Estrogen signaling pathway_Homo sapiens_hsa049150.06816454
130Bile secretion_Homo sapiens_hsa049760.06671956
131Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.06529163
132Dilated cardiomyopathy_Homo sapiens_hsa054140.06524493

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