LEPR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of branching involved in prostate gland morphogenesis (GO:0060687)8.41436394
2complement activation, alternative pathway (GO:0006957)8.13945113
3prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060526.85710852
4exogenous drug catabolic process (GO:0042738)6.81655839
5regulation of protein activation cascade (GO:2000257)6.70174976
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.50563236
7L-phenylalanine catabolic process (GO:0006559)6.50563236
8regulation of complement activation (GO:0030449)6.45277909
9blood coagulation, intrinsic pathway (GO:0007597)6.41870977
10drug catabolic process (GO:0042737)6.41057661
11omega-hydroxylase P450 pathway (GO:0097267)6.20745659
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.18077218
13lateral sprouting from an epithelium (GO:0060601)6.07568911
14mesenchymal-epithelial cell signaling (GO:0060638)6.01353685
15epoxygenase P450 pathway (GO:0019373)5.98411650
16cell proliferation involved in metanephros development (GO:0072203)5.96932732
17cell proliferation involved in kidney development (GO:0072111)5.81691835
18L-phenylalanine metabolic process (GO:0006558)5.77293442
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.77293442
20regulation of fibrinolysis (GO:0051917)5.77248036
21fibrinolysis (GO:0042730)5.62795956
22negative regulation of fibrinolysis (GO:0051918)5.61948316
23protein carboxylation (GO:0018214)5.59776992
24peptidyl-glutamic acid carboxylation (GO:0017187)5.59776992
25regulation of branching involved in salivary gland morphogenesis (GO:0060693)5.44598599
26bone trabecula formation (GO:0060346)5.43411559
27phenylpropanoid metabolic process (GO:0009698)5.16037004
28ethanol oxidation (GO:0006069)4.82778672
29negative regulation of norepinephrine secretion (GO:0010700)4.75742626
30branching involved in salivary gland morphogenesis (GO:0060445)4.73741695
31positive regulation of hemostasis (GO:1900048)4.68002551
32positive regulation of blood coagulation (GO:0030194)4.68002551
33bile acid biosynthetic process (GO:0006699)4.67478760
34protein activation cascade (GO:0072376)4.64607279
35glyoxylate metabolic process (GO:0046487)4.61695421
36branching involved in prostate gland morphogenesis (GO:0060442)4.58579338
37drug metabolic process (GO:0017144)4.55397405
38radial glial cell differentiation (GO:0060019)4.52953455
39urea metabolic process (GO:0019627)4.50533347
40regulation of triglyceride catabolic process (GO:0010896)4.44049409
41negative regulation of blood coagulation (GO:0030195)4.43845758
42negative regulation of hemostasis (GO:1900047)4.43845758
43negative regulation of osteoblast proliferation (GO:0033689)4.36612562
44imidazole-containing compound metabolic process (GO:0052803)4.36023427
45cellular response to vitamin D (GO:0071305)4.34977208
46craniofacial suture morphogenesis (GO:0097094)4.33446082
47aromatic amino acid family catabolic process (GO:0009074)4.29536576
48tonic smooth muscle contraction (GO:0014820)4.27737866
49positive regulation of endothelial cell differentiation (GO:0045603)4.25248430
50mesenchymal cell proliferation (GO:0010463)4.22971262
51protein localization to cell surface (GO:0034394)4.22422731
52regulation of non-canonical Wnt signaling pathway (GO:2000050)4.19625249
53artery smooth muscle contraction (GO:0014824)4.17171837
54positive regulation of coagulation (GO:0050820)4.16979092
55nitrogen cycle metabolic process (GO:0071941)4.14504548
56cellular glucuronidation (GO:0052695)4.14113381
57acylglycerol homeostasis (GO:0055090)4.13711164
58triglyceride homeostasis (GO:0070328)4.13711164
59regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.13134320
60endothelial cell differentiation (GO:0045446)4.10307815
61negative regulation of coagulation (GO:0050819)4.09017604
62macromolecular complex remodeling (GO:0034367)4.08930618
63plasma lipoprotein particle remodeling (GO:0034369)4.08930618
64protein-lipid complex remodeling (GO:0034368)4.08930618
65branching involved in labyrinthine layer morphogenesis (GO:0060670)4.07504973
66protoporphyrinogen IX metabolic process (GO:0046501)4.05741749
67tyrosine metabolic process (GO:0006570)4.01513083
68complement activation (GO:0006956)4.01125047
69bile acid metabolic process (GO:0008206)3.99181443
70regulation of endothelial cell differentiation (GO:0045601)3.98775157
71mesodermal cell differentiation (GO:0048333)3.97102935
72regulation of plasminogen activation (GO:0010755)3.97080448
73oxidative demethylation (GO:0070989)3.96773371
74low-density lipoprotein particle remodeling (GO:0034374)3.96695667
75negative regulation of wound healing (GO:0061045)3.96391125
76S-adenosylmethionine metabolic process (GO:0046500)3.93196995
77regulation of cholesterol esterification (GO:0010872)3.91134813
78cranial suture morphogenesis (GO:0060363)3.90007084
79high-density lipoprotein particle remodeling (GO:0034375)3.89558914
80uronic acid metabolic process (GO:0006063)3.84351519
81glucuronate metabolic process (GO:0019585)3.84351519
82ethanol metabolic process (GO:0006067)3.82460863
83renal system development (GO:0072001)3.75261793
84opsonization (GO:0008228)3.74722465
85negative regulation of lipase activity (GO:0060192)3.72803582
86urea cycle (GO:0000050)3.69722324
87blood vessel maturation (GO:0001955)3.65675820
88xenobiotic catabolic process (GO:0042178)3.65206200
89negative regulation of sterol transport (GO:0032372)3.62712201
90negative regulation of cholesterol transport (GO:0032375)3.62712201
91vascular endothelial growth factor signaling pathway (GO:0038084)3.62540253
92keratinocyte proliferation (GO:0043616)3.62321622
93reverse cholesterol transport (GO:0043691)3.61950761
94regulation of humoral immune response (GO:0002920)3.60657938
95complement activation, classical pathway (GO:0006958)3.60440008
96cellular response to cholesterol (GO:0071397)3.56380848
97branch elongation of an epithelium (GO:0060602)3.50200444
98retinal metabolic process (GO:0042574)3.49919930
99regulation of hemostasis (GO:1900046)3.47418608
100regulation of blood coagulation (GO:0030193)3.47418608
101protoporphyrinogen IX biosynthetic process (GO:0006782)3.46406788
102bile acid and bile salt transport (GO:0015721)3.44833951
103cytolysis (GO:0019835)3.40013927
104phospholipid homeostasis (GO:0055091)3.38449106
105regulation of lipoprotein metabolic process (GO:0050746)3.38219006
106lymphangiogenesis (GO:0001946)3.36881363
107iron ion import (GO:0097286)3.36120504
108smooth muscle tissue development (GO:0048745)3.35456229
109regulation of keratinocyte proliferation (GO:0010837)3.35305972
110positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.33785003
111regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.33785003
112prostate gland epithelium morphogenesis (GO:0060740)3.32883072
113negative regulation of JUN kinase activity (GO:0043508)3.31137622
114negative regulation of fibroblast apoptotic process (GO:2000270)3.28842797
115serine family amino acid catabolic process (GO:0009071)3.26467765
116sequestering of extracellular ligand from receptor (GO:0035581)3.24738037
117somite development (GO:0061053)3.24044721
118glomerular filtration (GO:0003094)3.23928016
119regulation of osteoblast proliferation (GO:0033688)3.23276818
120acute-phase response (GO:0006953)3.22869504
121positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.21556460
122positive regulation of cholesterol efflux (GO:0010875)3.20885103
123regulation of coagulation (GO:0050818)3.19601266
124cell migration involved in heart development (GO:0060973)3.18569241
125response to follicle-stimulating hormone (GO:0032354)3.16237212
126regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.16042525
127endocrine process (GO:0050886)3.16042525
128regulation of systemic arterial blood pressure by hormone (GO:0001990)3.16042525
129positive regulation of sterol transport (GO:0032373)3.15063703
130positive regulation of cholesterol transport (GO:0032376)3.15063703
131response to BMP (GO:0071772)3.14093588
132cellular response to BMP stimulus (GO:0071773)3.14093588
133otic vesicle formation (GO:0030916)3.13350967
134planar cell polarity pathway involved in neural tube closure (GO:0090179)3.11515286
135positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.11513031
136platelet degranulation (GO:0002576)3.10250507
137cellular ketone body metabolic process (GO:0046950)3.09982878
138renal filtration (GO:0097205)3.08610281
139cellular response to prostaglandin stimulus (GO:0071379)3.08058095
140axis elongation (GO:0003401)3.07917084
141plasma lipoprotein particle organization (GO:0071827)3.07845314
142positive regulation of wound healing (GO:0090303)3.07836072
143digestive tract morphogenesis (GO:0048546)3.06764789
144dorsal/ventral axis specification (GO:0009950)3.05629245
145trabecula formation (GO:0060343)3.04375822
146lung lobe morphogenesis (GO:0060463)3.03116838
147amino-acid betaine metabolic process (GO:0006577)3.02107718
148phospholipid efflux (GO:0033700)3.01202521
149cellular response to vitamin (GO:0071295)2.99690143
150glycine metabolic process (GO:0006544)2.98084780
151arginine catabolic process (GO:0006527)2.97583684
152valine metabolic process (GO:0006573)2.97170118
153arginine metabolic process (GO:0006525)2.95920074
154regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.95652571
155atrioventricular valve morphogenesis (GO:0003181)2.94806800
156positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.93648203
157positive regulation of fat cell differentiation (GO:0045600)2.93295343
158triglyceride catabolic process (GO:0019433)2.92046195
159protein heterotrimerization (GO:0070208)2.91740232
160mesenchymal cell differentiation (GO:0048762)2.91515765
161lymph vessel development (GO:0001945)2.91479369
162disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.91413426
163killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.91413426
164negative regulation of osteoclast differentiation (GO:0045671)2.91341146
165plasma lipoprotein particle clearance (GO:0034381)2.91170690
166protein-lipid complex subunit organization (GO:0071825)2.90940737
167vascular smooth muscle contraction (GO:0014829)2.90612423
168negative regulation of humoral immune response (GO:0002921)2.90091747
169glutamate metabolic process (GO:0006536)2.86917082
170cellular response to sterol (GO:0036315)2.86346089
171negative regulation of androgen receptor signaling pathway (GO:0060766)2.86239487
172positive regulation of cell junction assembly (GO:1901890)2.85405402
173positive regulation of focal adhesion assembly (GO:0051894)2.85405402
174negative regulation of complement activation (GO:0045916)2.84443457
175limb bud formation (GO:0060174)2.82920901
176negative regulation of catecholamine secretion (GO:0033604)2.82142362
177lung epithelium development (GO:0060428)2.82088407
178regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.82027103
179transcytosis (GO:0045056)2.81074397
180regulation of smooth muscle cell differentiation (GO:0051150)2.80993846
181retina vasculature morphogenesis in camera-type eye (GO:0061299)2.79658967
182hair follicle morphogenesis (GO:0031069)2.75708639
183basement membrane organization (GO:0071711)2.73050284
184lung alveolus development (GO:0048286)2.72221306
185hormone catabolic process (GO:0042447)2.71126874
186organ formation (GO:0048645)2.70627792
187response to prostaglandin E (GO:0034695)2.70468134
188hindlimb morphogenesis (GO:0035137)2.70323927
189negative regulation of protein activation cascade (GO:2000258)2.69969080
190organ induction (GO:0001759)2.68816702
191endothelium development (GO:0003158)2.68454125
192epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.66647780
193positive regulation of triglyceride lipase activity (GO:0061365)2.65731587
194positive regulation of lipoprotein lipase activity (GO:0051006)2.65731587
195negative regulation of platelet activation (GO:0010544)2.65302576
196midgut development (GO:0007494)2.63345827

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human4.88518948
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.75253170
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.51138251
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.20107142
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.04378458
6GATA1_19941826_ChIP-Seq_K562_Human2.86988138
7* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.83177005
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.75515911
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.56624359
10* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.50784941
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.38243509
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.30420517
13KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.30420517
14KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.30420517
15* GATA2_19941826_ChIP-Seq_K562_Human2.20476407
16SMAD_19615063_ChIP-ChIP_OVARY_Human2.19584205
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.16238810
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.15775447
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.00785181
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.97515473
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.97296907
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.97089123
23SCL_19346495_ChIP-Seq_HPC-7_Human1.95998869
24ESR1_21235772_ChIP-Seq_MCF-7_Human1.92048421
25* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.87679854
26CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.87606967
27* GATA2_21666600_ChIP-Seq_HMVEC_Human1.86951516
28ZNF217_24962896_ChIP-Seq_MCF-7_Human1.84281168
29SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.83558205
30CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.80611639
31AR_21572438_ChIP-Seq_LNCaP_Human1.78486746
32IGF1R_20145208_ChIP-Seq_DFB_Human1.78209501
33ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.77857305
34* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.76428770
35TAF15_26573619_Chip-Seq_HEK293_Human1.75263790
36HTT_18923047_ChIP-ChIP_STHdh_Human1.75245758
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.71764392
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.70918545
39* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.64133083
40NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.60411457
41CJUN_26792858_Chip-Seq_BT549_Human1.59368067
42GBX2_23144817_ChIP-Seq_PC3_Human1.56654212
43* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.55340115
44* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.54607412
45* LXR_22158963_ChIP-Seq_LIVER_Mouse1.53717874
46NRF2_20460467_ChIP-Seq_MEFs_Mouse1.51205592
47NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.51205592
48* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50096250
49RNF2_18974828_ChIP-Seq_MESCs_Mouse1.48533900
50EZH2_18974828_ChIP-Seq_MESCs_Mouse1.48533900
51SALL4_18804426_ChIP-ChIP_XEN_Mouse1.48531100
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.47323908
53* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47315392
54HNFA_21074721_ChIP-Seq_CACO-2_Human1.46683616
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.46045305
56* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.45685780
57EP300_21415370_ChIP-Seq_HL-1_Mouse1.44140593
58CLOCK_20551151_ChIP-Seq_293T_Human1.43613809
59PHF8_20622853_ChIP-Seq_HELA_Human1.43452587
60* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40239981
61CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.38201371
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.37704967
63* AHR_22903824_ChIP-Seq_MCF-7_Human1.36613604
64NFYA_21822215_ChIP-Seq_K562_Human1.36386478
65* RXR_22158963_ChIP-Seq_LIVER_Mouse1.36077986
66* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.35875866
67* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.35486693
68NFYB_21822215_ChIP-Seq_K562_Human1.35078332
69TP53_18474530_ChIP-ChIP_U2OS_Human1.34972993
70TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.33136738
71TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33015209
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.32840498
73CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.32548878
74CDX2_20551321_ChIP-Seq_CACO-2_Human1.30542002
75TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.30180374
76RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29807700
77* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.29746819
78CDX2_22108803_ChIP-Seq_LS180_Human1.27055367
79LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.26897044
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26278626
81PPAR_26484153_Chip-Seq_NCI-H1993_Human1.25596319
82* STAT3_23295773_ChIP-Seq_U87_Human1.24643419
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24203354
84TBL1_22424771_ChIP-Seq_293T_Human1.23603230
85P300_19829295_ChIP-Seq_ESCs_Human1.23285895
86EZH2_27304074_Chip-Seq_ESCs_Mouse1.22839742
87SALL4_22934838_ChIP-ChIP_CD34+_Human1.22306038
88ETV1_20927104_ChIP-Seq_GIST48_Human1.21394674
89* ARNT_22903824_ChIP-Seq_MCF-7_Human1.21339344
90BCAT_22108803_ChIP-Seq_LS180_Human1.21170598
91TBX3_20139965_ChIP-Seq_ESCs_Mouse1.19878576
92TBX3_20139965_ChIP-Seq_MESCs_Mouse1.18931198
93* FOXA2_19822575_ChIP-Seq_HepG2_Human1.18736933
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18319996
95PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17677821
96CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16961141
97* SMAD4_21799915_ChIP-Seq_A2780_Human1.15725679
98FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15375659
99VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14900317
100PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13353242
101OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13337036
102SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13268440
103CBX2_22325352_ChIP-Seq_293T-Rex_Human1.13012343
104TCF4_18268006_ChIP-ChIP_LS174T_Human1.12717397
105PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.12379013
106* SOX2_20726797_ChIP-Seq_SW620_Human1.11807509
107ISL1_27105846_Chip-Seq_CPCs_Mouse1.09591294
108RXR_22108803_ChIP-Seq_LS180_Human1.09556087
109TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09485855
110* HNF4A_19822575_ChIP-Seq_HepG2_Human1.09342148
111NANOG_18555785_Chip-Seq_ESCs_Mouse1.08719326
112MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08244786
113NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07720211
114JARID2_20064375_ChIP-Seq_MESCs_Mouse1.07070283
115VDR_22108803_ChIP-Seq_LS180_Human1.06760186
116RARG_19884340_ChIP-ChIP_MEFs_Mouse1.06598140
117SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.06153785
118CRX_20693478_ChIP-Seq_RETINA_Mouse1.05932186
119TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.05356086
120GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.05093509
121FUS_26573619_Chip-Seq_HEK293_Human1.04548200
122GATA6_21074721_ChIP-Seq_CACO-2_Human1.03806568
123P53_22387025_ChIP-Seq_ESCs_Mouse1.02500646
124ESR1_20079471_ChIP-ChIP_T-47D_Human1.02304786
125* TCF4_23295773_ChIP-Seq_U87_Human1.02301524
126EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02023141
127SOX9_24532713_ChIP-Seq_HFSC_Mouse1.01836383
128RBPJ_21746931_ChIP-Seq_IB4_Human1.01593052
129E2F1_18555785_Chip-Seq_ESCs_Mouse1.01465431
130STAT3_18555785_Chip-Seq_ESCs_Mouse1.01424262
131AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00973231
132JARID2_20075857_ChIP-Seq_MESCs_Mouse1.00848343
133* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00437837
134RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.99639210
135WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99572081
136ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99452501
137* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99433465
138TAL1_26923725_Chip-Seq_HPCs_Mouse0.99100970
139NANOG_19829295_ChIP-Seq_ESCs_Human0.99095356
140SOX2_19829295_ChIP-Seq_ESCs_Human0.99095356
141EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98534994
142IRF1_19129219_ChIP-ChIP_H3396_Human0.98222908
143Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98096718
144CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97828947
145TP53_16413492_ChIP-PET_HCT116_Human0.97041577
146FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96749211
147AR_25329375_ChIP-Seq_VCAP_Human0.96587777
148SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96232746
149ER_23166858_ChIP-Seq_MCF-7_Human0.95762638
150* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.94291737
151PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93626115
152FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.93314895
153WT1_19549856_ChIP-ChIP_CCG9911_Human0.93244026
154THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93045474
155* BRD4_25478319_ChIP-Seq_HGPS_Human0.92727761
156RNF2_27304074_Chip-Seq_ESCs_Mouse0.90915058
157SMAD4_21741376_ChIP-Seq_HESCs_Human0.90778887
158WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.89687046
159SMAD3_21741376_ChIP-Seq_EPCs_Human0.89402772
160IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.89142086

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology4.76443515
2MP0006054_spinal_hemorrhage4.15286711
3MP0010368_abnormal_lymphatic_system4.13744614
4MP0003195_calcinosis3.71964929
5MP0004147_increased_porphyrin_level3.61573067
6* MP0004272_abnormal_basement_membrane3.55115226
7MP0005464_abnormal_platelet_physiology3.33738594
8MP0003656_abnormal_erythrocyte_physiolo3.32298106
9MP0005248_abnormal_Harderian_gland3.28220205
10MP0008875_abnormal_xenobiotic_pharmacok3.25774091
11MP0003724_increased_susceptibility_to3.03593037
12MP0002938_white_spotting2.98528438
13MP0000566_synostosis2.97615116
14MP0002138_abnormal_hepatobiliary_system2.93464021
15* MP0010329_abnormal_lipoprotein_level2.77679951
16MP0001879_abnormal_lymphatic_vessel2.64151503
17MP0008438_abnormal_cutaneous_collagen2.51008651
18* MP0005187_abnormal_penis_morphology2.40105692
19MP0001958_emphysema2.38261051
20MP0001545_abnormal_hematopoietic_system2.27848153
21MP0005397_hematopoietic_system_phenotyp2.27848153
22MP0002295_abnormal_pulmonary_circulatio2.26238746
23MP0003011_delayed_dark_adaptation2.20134870
24MP0003279_aneurysm2.19465790
25MP0003868_abnormal_feces_composition2.08904787
26MP0000767_abnormal_smooth_muscle2.04808538
27MP0001299_abnormal_eye_distance/2.04160868
28MP0009250_abnormal_appendicular_skeleto1.96318434
29MP0004134_abnormal_chest_morphology1.95450183
30MP0000537_abnormal_urethra_morphology1.93064044
31MP0002108_abnormal_muscle_morphology1.85395817
32MP0003950_abnormal_plasma_membrane1.84253075
33MP0005508_abnormal_skeleton_morphology1.78584758
34MP0005083_abnormal_biliary_tract1.77535330
35MP0005257_abnormal_intraocular_pressure1.72659333
36* MP0005332_abnormal_amino_acid1.71380066
37MP0000427_abnormal_hair_cycle1.66105947
38MP0002282_abnormal_trachea_morphology1.61817389
39MP0000462_abnormal_digestive_system1.59678374
40MP0005670_abnormal_white_adipose1.59169185
41MP0000579_abnormal_nail_morphology1.58697365
42MP0003252_abnormal_bile_duct1.57451652
43* MP0000609_abnormal_liver_physiology1.54791717
44* MP0002118_abnormal_lipid_homeostasis1.54624989
45MP0002098_abnormal_vibrissa_morphology1.52433121
46MP0000428_abnormal_craniofacial_morphol1.49265097
47MP0003385_abnormal_body_wall1.48916010
48MP0002132_abnormal_respiratory_system1.48795882
49MP0005167_abnormal_blood-brain_barrier1.47008784
50MP0005275_abnormal_skin_tensile1.46999329
51MP0001666_abnormal_nutrient_absorption1.43850527
52MP0004130_abnormal_muscle_cell1.41774974
53* MP0005595_abnormal_vascular_smooth1.40855519
54MP0000013_abnormal_adipose_tissue1.39956105
55MP0000516_abnormal_urinary_system1.36234430
56MP0005367_renal/urinary_system_phenotyp1.36234430
57MP0003566_abnormal_cell_adhesion1.35870980
58* MP0008775_abnormal_heart_ventricle1.35629923
59MP0002009_preneoplasia1.35062121
60MP0004084_abnormal_cardiac_muscle1.33851350
61MP0010030_abnormal_orbit_morphology1.30346555
62MP0003941_abnormal_skin_development1.30034813
63MP0001243_abnormal_dermal_layer1.27805508
64MP0003186_abnormal_redox_activity1.26355279
65MP0009697_abnormal_copulation1.24549676
66MP0001177_atelectasis1.20868250
67MP0002254_reproductive_system_inflammat1.20853483
68MP0009278_abnormal_bone_marrow1.19974524
69* MP0000598_abnormal_liver_morphology1.19928130
70MP0005636_abnormal_mineral_homeostasis1.19380489
71MP0004782_abnormal_surfactant_physiolog1.18387166
72MP0009053_abnormal_anal_canal1.18236208
73* MP0000647_abnormal_sebaceous_gland1.17786253
74MP0001764_abnormal_homeostasis1.17064327
75MP0003091_abnormal_cell_migration1.16949379
76MP0002896_abnormal_bone_mineralization1.16649785
77MP0003942_abnormal_urinary_system1.15827036
78MP0005623_abnormal_meninges_morphology1.13962639
79MP0009780_abnormal_chondrocyte_physiolo1.13350006
80* MP0005164_abnormal_response_to1.11253550
81MP0000762_abnormal_tongue_morphology1.10373551
82MP0005085_abnormal_gallbladder_physiolo1.09358690
83MP0003567_abnormal_fetal_cardiomyocyte1.08505595
84MP0005360_urolithiasis1.08252901
85MP0003136_yellow_coat_color1.07919974
86MP0002876_abnormal_thyroid_physiology1.07723134
87MP0003879_abnormal_hair_cell1.07360828
88MP0000465_gastrointestinal_hemorrhage1.07287471
89MP0003806_abnormal_nucleotide_metabolis1.07106721
90MP0003191_abnormal_cellular_cholesterol1.07009219
91MP0004215_abnormal_myocardial_fiber1.06045618
92MP0005171_absent_coat_pigmentation1.05237178
93MP0001346_abnormal_lacrimal_gland1.05027662
94MP0005408_hypopigmentation1.03975527
95MP0001542_abnormal_bone_strength1.03184944
96MP0000751_myopathy1.02353353
97MP0001293_anophthalmia1.02228252
98MP0001915_intracranial_hemorrhage1.00781815
99MP0002133_abnormal_respiratory_system1.00475826
100MP0005388_respiratory_system_phenotype1.00475826
101* MP0002971_abnormal_brown_adipose0.99601794
102MP0003935_abnormal_craniofacial_develop0.98972725
103MP0002998_abnormal_bone_remodeling0.98913385
104MP0002115_abnormal_skeleton_extremities0.98189471
105MP0003718_maternal_effect0.97732746
106MP0004019_abnormal_vitamin_homeostasis0.97418471
107MP0001851_eye_inflammation0.97110461
108MP0005647_abnormal_sex_gland0.96732622
109MP0005409_darkened_coat_color0.96168330
110* MP0000249_abnormal_blood_vessel0.95940685
111MP0005395_other_phenotype0.95887183
112MP0002168_other_aberrant_phenotype0.95823787
113MP0004036_abnormal_muscle_relaxation0.95787497
114MP0000383_abnormal_hair_follicle0.95406243
115MP0005646_abnormal_pituitary_gland0.94347677
116* MP0009763_increased_sensitivity_to0.93340189
117* MP0002128_abnormal_blood_circulation0.92979577
118MP0000534_abnormal_ureter_morphology0.92555994
119MP0000163_abnormal_cartilage_morphology0.92388049
120MP0005084_abnormal_gallbladder_morpholo0.91926298
121MP0003937_abnormal_limbs/digits/tail_de0.91863404
122MP0003828_pulmonary_edema0.91611893
123MP0006138_congestive_heart_failure0.90559828
124MP0009764_decreased_sensitivity_to0.90365883
125* MP0001661_extended_life_span0.88770418
126MP0002932_abnormal_joint_morphology0.88546228
127MP0002109_abnormal_limb_morphology0.87931252
128* MP0001614_abnormal_blood_vessel0.87376442
129* MP0002925_abnormal_cardiovascular_devel0.86851258
130MP0005390_skeleton_phenotype0.86734345
131MP0005023_abnormal_wound_healing0.86261161
132MP0008004_abnormal_stomach_pH0.83341610
133MP0002139_abnormal_hepatobiliary_system0.83278652
134MP0001175_abnormal_lung_morphology0.83076181
135MP0003690_abnormal_glial_cell0.82854169
136MP0002116_abnormal_craniofacial_bone0.82512587
137MP0004885_abnormal_endolymph0.81228242
138* MP0004883_abnormal_blood_vessel0.79973237
139MP0003943_abnormal_hepatobiliary_system0.79943349
140* MP0009643_abnormal_urine_homeostasis0.79310777
141MP0003705_abnormal_hypodermis_morpholog0.78674552
142* MP0000230_abnormal_systemic_arterial0.77523484
143* MP0005535_abnormal_body_temperature0.77359775
144MP0005365_abnormal_bile_salt0.76714006
145MP0000003_abnormal_adipose_tissue0.76385171
146MP0002060_abnormal_skin_morphology0.74807671
147MP0009840_abnormal_foam_cell0.74680105
148MP0005319_abnormal_enzyme/_coenzyme0.74635304
149MP0010678_abnormal_skin_adnexa0.73907740
150* MP0009642_abnormal_blood_homeostasis0.73574810
151MP0003938_abnormal_ear_development0.73265595
152MP0005666_abnormal_adipose_tissue0.72952558
153* MP0000343_altered_response_to0.72925916
154* MP0005376_homeostasis/metabolism_phenot0.69685274
155* MP0005385_cardiovascular_system_phenoty0.66360023
156* MP0001544_abnormal_cardiovascular_syste0.66360023
157MP0004808_abnormal_hematopoietic_stem0.64674525
158MP0002332_abnormal_exercise_endurance0.63842117
159MP0005410_abnormal_fertilization0.62528683
160MP0002090_abnormal_vision0.60288844
161MP0001727_abnormal_embryo_implantation0.59955285
162* MP0002078_abnormal_glucose_homeostasis0.56975860
163* MP0005334_abnormal_fat_pad0.56200436
164MP0004484_altered_response_of0.55476736
165MP0005375_adipose_tissue_phenotype0.55214854
166MP0009115_abnormal_fat_cell0.54194795

Predicted human phenotypes

RankGene SetZ-score
1Complement deficiency (HP:0004431)8.17394318
2Abnormality of the parietal bone (HP:0002696)7.02277969
3Abnormality of complement system (HP:0005339)6.44481034
4Midline defect of the nose (HP:0004122)5.89836233
5Hyperlipoproteinemia (HP:0010980)5.75541141
6Short 4th metacarpal (HP:0010044)5.72718894
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)5.72718894
8Abnormality of monocarboxylic acid metabolism (HP:0010996)5.60630226
9Prolonged partial thromboplastin time (HP:0003645)5.57711696
10Menorrhagia (HP:0000132)5.49688557
11Poikilocytosis (HP:0004447)5.49628748
12Increased mean platelet volume (HP:0011877)5.48371917
13Abnormality of aromatic amino acid family metabolism (HP:0004338)5.47433658
14Abnormality of the common coagulation pathway (HP:0010990)5.18989377
15Conjugated hyperbilirubinemia (HP:0002908)5.11756360
16Prolonged bleeding time (HP:0003010)5.09467149
17Toxemia of pregnancy (HP:0100603)5.01575208
18Abnormal platelet volume (HP:0011876)4.90942097
19Joint hemorrhage (HP:0005261)4.90642649
20Hypobetalipoproteinemia (HP:0003563)4.56697451
21Broad metatarsal (HP:0001783)4.54356923
22Abnormality of the heme biosynthetic pathway (HP:0010472)4.49147163
23Gingival bleeding (HP:0000225)4.41320465
24Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)4.22298891
25Xanthomatosis (HP:0000991)4.21831900
26Nasolacrimal duct obstruction (HP:0000579)4.13512237
27Acanthocytosis (HP:0001927)4.11308635
28Abnormality of the 4th metacarpal (HP:0010012)4.08731265
29Spontaneous abortion (HP:0005268)4.05985320
30Epistaxis (HP:0000421)4.05704456
31Trigonocephaly (HP:0000243)3.98362276
32Systemic lupus erythematosus (HP:0002725)3.97563164
33Abnormality of the nasal septum (HP:0000419)3.96621470
34Purpura (HP:0000979)3.93247324
35Glomerulonephritis (HP:0000099)3.77409928
36Shallow orbits (HP:0000586)3.75386838
37Broad face (HP:0000283)3.74365101
38Osteomalacia (HP:0002749)3.72362907
39Intrahepatic cholestasis (HP:0001406)3.71712152
40Abnormal platelet function (HP:0011869)3.69609485
41Impaired platelet aggregation (HP:0003540)3.69609485
42Abnormality of the distal phalanx of the thumb (HP:0009617)3.68904695
43Aplasia cutis congenita (HP:0001057)3.59487696
44Aplasia involving bones of the upper limbs (HP:0009823)3.57000755
45Aplasia of the phalanges of the hand (HP:0009802)3.57000755
46Aplasia involving bones of the extremities (HP:0009825)3.57000755
47Abnormality of the intrinsic pathway (HP:0010989)3.49251166
48Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.44770496
49Reticulocytosis (HP:0001923)3.44484563
50Neoplasm of the heart (HP:0100544)3.39294153
51Hyperbilirubinemia (HP:0002904)3.26190718
52Abnormal gallbladder physiology (HP:0012438)3.24590229
53Cholecystitis (HP:0001082)3.24590229
54Spontaneous hematomas (HP:0007420)3.19347460
55Depressed nasal tip (HP:0000437)3.14200007
56Cholelithiasis (HP:0001081)3.12768122
57Abnormality of pyrimidine metabolism (HP:0004353)3.08935185
58Petechiae (HP:0000967)3.08443177
59Abnormality of the lacrimal duct (HP:0011481)3.04541605
60Abnormal gallbladder morphology (HP:0012437)3.02293376
61Abnormality of the nasolacrimal system (HP:0000614)2.97877068
62Short phalanx of the thumb (HP:0009660)2.95186974
63Arthropathy (HP:0003040)2.89289381
64Short hallux (HP:0010109)2.89196483
65Vitreoretinal degeneration (HP:0000655)2.88852141
66Anteriorly placed anus (HP:0001545)2.88577131
67Recurrent corneal erosions (HP:0000495)2.86815448
68White forelock (HP:0002211)2.86269882
69Aortic aneurysm (HP:0004942)2.82904072
70Nephritis (HP:0000123)2.80985177
71Down-sloping shoulders (HP:0200021)2.79039069
72Humeroradial synostosis (HP:0003041)2.78721092
73Synostosis involving the elbow (HP:0003938)2.78721092
74Abnormality of incisor morphology (HP:0011063)2.77883939
75Bone cyst (HP:0012062)2.77809256
76Hypolipoproteinemia (HP:0010981)2.77423056
77Mitral stenosis (HP:0001718)2.73425284
78Alacrima (HP:0000522)2.72680818
79Partial duplication of thumb phalanx (HP:0009944)2.71716731
80Deep venous thrombosis (HP:0002625)2.70963387
81Broad hallux (HP:0010055)2.70068807
82Partial duplication of the phalanx of hand (HP:0009999)2.69463515
83Hepatocellular carcinoma (HP:0001402)2.68415432
84Premature skin wrinkling (HP:0100678)2.65990059
85Coronal craniosynostosis (HP:0004440)2.64705670
86Myocardial infarction (HP:0001658)2.59237605
87Aplasia/Hypoplasia of the hallux (HP:0008362)2.58196953
88Patchy hypopigmentation of hair (HP:0011365)2.57273386
89Aortic dissection (HP:0002647)2.56688761
90Abnormal hemoglobin (HP:0011902)2.54493544
91Abnormality of methionine metabolism (HP:0010901)2.54368238
92Broad toe (HP:0001837)2.49300639
93Premature rupture of membranes (HP:0001788)2.47059652
94Infantile muscular hypotonia (HP:0008947)2.45426247
95Hypercholesterolemia (HP:0003124)2.44459205
96Large earlobe (HP:0009748)2.44228048
97Abnormality of the incisor (HP:0000676)2.43784785
98Fat malabsorption (HP:0002630)2.42323853
99Thrombophlebitis (HP:0004418)2.39952480
100Protrusio acetabuli (HP:0003179)2.39478537
101Hyperammonemia (HP:0001987)2.35875541
102Supernumerary ribs (HP:0005815)2.35176322
103Milia (HP:0001056)2.32982194
104Conical tooth (HP:0000698)2.31033051
105Exostoses (HP:0100777)2.30323327
106Preaxial foot polydactyly (HP:0001841)2.29215334
107Deformed sella turcica (HP:0002681)2.28867272
108Abnormality of transition element cation homeostasis (HP:0011030)2.28608945
109Hypoplastic ischia (HP:0003175)2.28169619
110Conjunctival telangiectasia (HP:0000524)2.26125693
111Abnormality of iron homeostasis (HP:0011031)2.23719891
112Bilateral microphthalmos (HP:0007633)2.23165354
113Abnormality of the sella turcica (HP:0002679)2.22032450
114Rickets (HP:0002748)2.20121020
115Epidermoid cyst (HP:0200040)2.19890288
116Recurrent gram-negative bacterial infections (HP:0005420)2.19032830
117Generalized aminoaciduria (HP:0002909)2.16727205
118Bell-shaped thorax (HP:0001591)2.16634534
119Abnormality of the ischium (HP:0003174)2.14697793
120Sparse lateral eyebrow (HP:0005338)2.14285076
121Rectal fistula (HP:0100590)2.14143011
122Rectovaginal fistula (HP:0000143)2.14143011
123Paralysis (HP:0003470)2.14123252
124Cardiovascular calcification (HP:0011915)2.13857319
125Vascular tortuosity (HP:0004948)2.13370815
126Peritonitis (HP:0002586)2.13140608
127Fair hair (HP:0002286)2.13023947
128Turricephaly (HP:0000262)2.12548947
129Abnormality of the proximal phalanges of the hand (HP:0009834)2.10630117
130Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.10256283
131Cerebral hemorrhage (HP:0001342)2.08546248
132Supernumerary bones of the axial skeleton (HP:0009144)2.08284200
133Abnormal number of incisors (HP:0011064)2.08173271
134Flat capital femoral epiphysis (HP:0003370)2.06193274
135Arterial tortuosity (HP:0005116)2.04951629
136Abnormality of sulfur amino acid metabolism (HP:0004339)2.03076171
137Nonimmune hydrops fetalis (HP:0001790)2.02896457
138Vascular calcification (HP:0004934)2.02833360
139Abnormality of the middle phalanges of the toes (HP:0010183)2.01599288
140Pulmonary artery stenosis (HP:0004415)2.01163501
141Steatorrhea (HP:0002570)2.00756575
142Abnormality of the phalanges of the 2nd finger (HP:0009541)2.00728472
143Vaginal fistula (HP:0004320)2.00248877
144Decreased lacrimation (HP:0000633)2.00102550
145Follicular hyperkeratosis (HP:0007502)1.98557664
146Abnormality of the vasculature of the conjunctiva (HP:0008054)1.97604475
147Esophageal varix (HP:0002040)1.97594923
148* Abnormality of the diencephalon (HP:0010662)1.96894771
149Abnormal pupillary function (HP:0007686)1.96645949
150Microglossia (HP:0000171)1.96623435
151Hypochromic microcytic anemia (HP:0004840)1.96242084
152Abnormal ossification of hand bones (HP:0005921)1.96033588
153Prominent supraorbital ridges (HP:0000336)1.94661303
154Hypoalphalipoproteinemia (HP:0003233)1.94185051
155Abnormal hand bone ossification (HP:0010660)1.94108107
156Bruising susceptibility (HP:0000978)1.93219507
157Abnormality of glutamine family amino acid metabolism (HP:0010902)1.92941020
158Abnormality of the gallbladder (HP:0005264)1.92324447
159Ankle contracture (HP:0006466)1.91718701
160Mesomelia (HP:0003027)1.91649677
161Cerebral aneurysm (HP:0004944)1.91352384
162Decreased skull ossification (HP:0004331)1.91340440
163Abnormal delivery (HP:0001787)1.89970317
164Bronchomalacia (HP:0002780)1.89806840
165Potter facies (HP:0002009)1.89378511
166Facial shape deformation (HP:0011334)1.89378511
167Concave nail (HP:0001598)1.89198309
168Intestinal fistula (HP:0100819)1.87935618
169Hypoplasia of the iris (HP:0007676)1.86963909
170Abnormality of aspartate family amino acid metabolism (HP:0010899)1.86633134
171Venous insufficiency (HP:0005293)1.86597435
172Microcytic anemia (HP:0001935)1.85809804
173Polycythemia (HP:0001901)1.83399141
174Abnormality of reticulocytes (HP:0004312)1.83149408
175Neoplasm of the oral cavity (HP:0100649)1.82410620
176Increased serum ferritin (HP:0003281)1.81947151
177Xerostomia (HP:0000217)1.80163166
178Abnormality of nucleobase metabolism (HP:0010932)1.79278666
179Accelerated skeletal maturation (HP:0005616)1.78528475
180Narrow palate (HP:0000189)1.77673486
181Wide anterior fontanel (HP:0000260)1.77401086
182Joint swelling (HP:0001386)1.76494919
183Nausea (HP:0002018)1.72845771
184Ileus (HP:0002595)1.70942035
185Hyperthyroidism (HP:0000836)1.70065765
186Cerebral palsy (HP:0100021)1.69083687
187Enlarged kidneys (HP:0000105)1.65684682
188Back pain (HP:0003418)1.65331546
189Hemorrhage of the eye (HP:0011885)1.64302246
190Truncus arteriosus (HP:0001660)1.63308584
191Chondrocalcinosis (HP:0000934)1.59219107
192Abnormality of Sharpey fibers (HP:0100685)1.57780200

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE16.36612609
2FGFR24.11826925
3LATS13.54080105
4TGFBR23.43719850
5PIK3CG3.40936747
6MST43.21942657
7EIF2AK13.20819183
8PDGFRA3.07472244
9AKT32.80552986
10MYLK2.77108259
11DDR22.58622832
12EPHB22.48025661
13FER2.40532578
14PDK22.32739727
15BRSK22.32594242
16NUAK12.21952115
17TRPM72.08227430
18KDR2.06309047
19EPHB11.79251923
20KIT1.70967022
21PDGFRB1.64894024
22RIPK41.64729000
23MAP3K21.63663697
24NTRK31.62738258
25KSR21.55244647
26BMPR21.51397802
27PIK3CA1.43699672
28TGFBR11.42979953
29NLK1.42169475
30LATS21.37598942
31EPHA31.37462518
32RAF11.37219304
33INSRR1.35774310
34PTK2B1.35064730
35MAP3K141.34818390
36MAPK71.34735228
37SIK11.30977057
38MAPKAPK31.29222097
39JAK21.28416214
40DMPK1.26803001
41ERN11.26294512
42MET1.23661331
43NEK61.16256394
44FGFR11.16246663
45STK31.14144089
46TNIK1.11835477
47MAP3K41.10779009
48SCYL21.08319181
49STK38L1.07871632
50CLK11.07795524
51GRK11.07289161
52PLK21.04403391
53PTK61.04147062
54CSNK1A1L1.04088813
55BTK1.03774531
56PRKACG1.02536975
57BMX1.01076146
58IRAK31.00613681
59MAPK121.00323949
60TTN0.99424899
61RET0.99259060
62ILK0.97442377
63PINK10.96174178
64TAOK30.95884080
65KSR10.95355033
66ABL20.92391653
67ERBB30.89800491
68CCNB10.88487642
69FLT30.87794306
70FRK0.86366691
71MAP3K60.83783150
72GSK3A0.83374035
73CAMKK20.81404888
74CSNK1G10.75092519
75MAP4K20.73461756
76FGFR40.73020082
77MAPK150.71998911
78CHUK0.71081851
79PRKD10.70513845
80EIF2AK30.69571734
81ZAP700.69109214
82BMPR1B0.69027035
83PRKCE0.67931298
84GRK50.66895976
85PAK20.66233653
86PRKG10.64565285
87PAK30.64329457
88CDC42BPA0.64008727
89ROCK10.63669055
90RIPK10.63542339
91STK40.63181300
92EEF2K0.62772394
93ERBB40.62471926
94PRKCQ0.62275958
95GRK70.60146558
96PRKACB0.60031504
97MAPKAPK50.59760648
98CSK0.59336456
99ADRBK20.55984030
100MAP2K10.55931324
101TEC0.55501178
102JAK10.53750454
103DAPK30.53125973
104MARK30.52799082
105IGF1R0.52213561
106PTK20.51921018
107PAK10.49274413
108ABL10.49032885
109PLK30.47758794
110ERBB20.45754909
111NEK90.45728952
112PRKCH0.44748411
113MAP3K70.44201464
114RPS6KA50.44077764
115CSNK1G30.43977021
116SYK0.43759810
117CAMK1D0.42842865
118STK390.42735906
119MAP3K30.42283262
120MUSK0.41846409
121CAMK10.41833296
122IRAK40.40896531
123CDK90.40828046
124ZAK0.40565430
125CAMK40.40507003
126INSR0.40181477
127CASK0.38953157
128TTK0.37873315
129ACVR1B0.37700665
130WNK10.37170092
131MST1R0.36933744
132HCK0.34605424
133PRKAA20.34511084
134ADRBK10.34472185
135MAPK40.34294041
136MAPK30.34288454
137DAPK20.33842338
138PKN10.33559585
139TBK10.32913592
140CAMK1G0.32873756
141FGFR30.32519976
142SGK2230.32279837
143SGK4940.32279837
144IKBKE0.31995587
145PRKCA0.31022559
146EGFR0.30400320
147SGK10.30165448
148IRAK10.30032453
149STK240.29939322
150PRKACA0.29429652
151PRKAA10.29034361
152EPHA20.28791483
153JAK30.28765851
154EIF2AK20.28532497

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.24013681
2ECM-receptor interaction_Homo sapiens_hsa045123.13676937
3Complement and coagulation cascades_Homo sapiens_hsa046102.99184698
4Caffeine metabolism_Homo sapiens_hsa002322.83357513
5Hedgehog signaling pathway_Homo sapiens_hsa043402.67533568
6Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.58450702
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.03182528
8Focal adhesion_Homo sapiens_hsa045102.02136355
9Vitamin digestion and absorption_Homo sapiens_hsa049771.98266703
10TGF-beta signaling pathway_Homo sapiens_hsa043501.95508013
11Drug metabolism - other enzymes_Homo sapiens_hsa009831.93324979
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.76110247
13Adherens junction_Homo sapiens_hsa045201.73364843
14Nitrogen metabolism_Homo sapiens_hsa009101.73029868
15Cyanoamino acid metabolism_Homo sapiens_hsa004601.67824877
16Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.64803061
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.64086716
18Protein digestion and absorption_Homo sapiens_hsa049741.62319818
19Staphylococcus aureus infection_Homo sapiens_hsa051501.61214075
20Amoebiasis_Homo sapiens_hsa051461.56272960
21Arachidonic acid metabolism_Homo sapiens_hsa005901.55284739
22Melanoma_Homo sapiens_hsa052181.54079608
23Histidine metabolism_Homo sapiens_hsa003401.49888459
24Malaria_Homo sapiens_hsa051441.45143739
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.42323273
26Prostate cancer_Homo sapiens_hsa052151.41195395
27Pathways in cancer_Homo sapiens_hsa052001.39799117
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.37242986
29PI3K-Akt signaling pathway_Homo sapiens_hsa041511.36255590
30Ovarian steroidogenesis_Homo sapiens_hsa049131.35480035
31One carbon pool by folate_Homo sapiens_hsa006701.33299929
32Vascular smooth muscle contraction_Homo sapiens_hsa042701.30988951
33Prion diseases_Homo sapiens_hsa050201.28230430
34Rap1 signaling pathway_Homo sapiens_hsa040151.25528871
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.22235625
36Hippo signaling pathway_Homo sapiens_hsa043901.21585054
37Propanoate metabolism_Homo sapiens_hsa006401.20227189
38Wnt signaling pathway_Homo sapiens_hsa043101.18125781
39Phenylalanine metabolism_Homo sapiens_hsa003601.17594057
40Small cell lung cancer_Homo sapiens_hsa052221.15563373
41Arginine biosynthesis_Homo sapiens_hsa002201.14894535
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.14665846
43Regulation of actin cytoskeleton_Homo sapiens_hsa048101.14616241
44Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.14006659
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.13287778
46Proteoglycans in cancer_Homo sapiens_hsa052051.13129252
47PPAR signaling pathway_Homo sapiens_hsa033201.12226448
48Ras signaling pathway_Homo sapiens_hsa040141.11072793
49Dilated cardiomyopathy_Homo sapiens_hsa054141.10581938
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09955062
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.09947779
52Pyruvate metabolism_Homo sapiens_hsa006201.09170516
53Tryptophan metabolism_Homo sapiens_hsa003801.06844439
54Bile secretion_Homo sapiens_hsa049761.05938757
55Retinol metabolism_Homo sapiens_hsa008301.05443256
56Toxoplasmosis_Homo sapiens_hsa051451.04869888
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.03633431
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02841921
59Vitamin B6 metabolism_Homo sapiens_hsa007501.01457630
60African trypanosomiasis_Homo sapiens_hsa051430.99287314
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95929939
62ABC transporters_Homo sapiens_hsa020100.94801632
63Axon guidance_Homo sapiens_hsa043600.91214513
64Dorso-ventral axis formation_Homo sapiens_hsa043200.88691433
65Chemical carcinogenesis_Homo sapiens_hsa052040.87350028
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87341034
67Renin secretion_Homo sapiens_hsa049240.86339720
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85529717
69Platelet activation_Homo sapiens_hsa046110.84670973
70* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83950327
71Peroxisome_Homo sapiens_hsa041460.82233364
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81282255
73cAMP signaling pathway_Homo sapiens_hsa040240.78915213
74Tight junction_Homo sapiens_hsa045300.78480077
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.75398968
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75333597
77Mineral absorption_Homo sapiens_hsa049780.75055304
78Fatty acid elongation_Homo sapiens_hsa000620.74977647
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74959279
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73299883
81Fat digestion and absorption_Homo sapiens_hsa049750.70648964
82Rheumatoid arthritis_Homo sapiens_hsa053230.70582166
83Fatty acid degradation_Homo sapiens_hsa000710.70272271
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68875017
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68136039
86Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.67838631
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67753533
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67417880
89beta-Alanine metabolism_Homo sapiens_hsa004100.67080160
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66817712
91Tyrosine metabolism_Homo sapiens_hsa003500.66766713
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.65838384
93Folate biosynthesis_Homo sapiens_hsa007900.65022534
94Sulfur metabolism_Homo sapiens_hsa009200.64206617
95Biosynthesis of amino acids_Homo sapiens_hsa012300.62323355
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61862056
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59056241
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58964523
99Carbon metabolism_Homo sapiens_hsa012000.58630827
100MicroRNAs in cancer_Homo sapiens_hsa052060.57835449
101Glycerolipid metabolism_Homo sapiens_hsa005610.57669851
102TNF signaling pathway_Homo sapiens_hsa046680.53475568
103Ether lipid metabolism_Homo sapiens_hsa005650.53055089
104Choline metabolism in cancer_Homo sapiens_hsa052310.52436007
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51740156
106Pertussis_Homo sapiens_hsa051330.51149326
107MAPK signaling pathway_Homo sapiens_hsa040100.49691160
108NF-kappa B signaling pathway_Homo sapiens_hsa040640.48470868
109Starch and sucrose metabolism_Homo sapiens_hsa005000.48344430
110Serotonergic synapse_Homo sapiens_hsa047260.46004943
111Insulin resistance_Homo sapiens_hsa049310.45998506
112Butanoate metabolism_Homo sapiens_hsa006500.44921167
113Linoleic acid metabolism_Homo sapiens_hsa005910.44504450
114Melanogenesis_Homo sapiens_hsa049160.44404854
115Fatty acid metabolism_Homo sapiens_hsa012120.43704982
116Glutathione metabolism_Homo sapiens_hsa004800.43353605
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43032868
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42714047
119Lysine degradation_Homo sapiens_hsa003100.42626188
120Systemic lupus erythematosus_Homo sapiens_hsa053220.42435041
121Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42082773
122Renin-angiotensin system_Homo sapiens_hsa046140.41233888
123Hepatitis C_Homo sapiens_hsa051600.40368244
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.40178769
125Steroid biosynthesis_Homo sapiens_hsa001000.39502279
126Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39337396
127Metabolic pathways_Homo sapiens_hsa011000.38303625
128Renal cell carcinoma_Homo sapiens_hsa052110.37317518
129Arginine and proline metabolism_Homo sapiens_hsa003300.37140069
130Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35182750
131Selenocompound metabolism_Homo sapiens_hsa004500.29202459
132Fatty acid biosynthesis_Homo sapiens_hsa000610.26391985
133Circadian rhythm_Homo sapiens_hsa047100.25943474
134* Adipocytokine signaling pathway_Homo sapiens_hsa049200.21071089
135Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.19409362
136SNARE interactions in vesicular transport_Homo sapiens_hsa041300.16298374
1372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.13390318
138Long-term depression_Homo sapiens_hsa047300.07998644
139Type II diabetes mellitus_Homo sapiens_hsa049300.07416539
140Pentose phosphate pathway_Homo sapiens_hsa000300.03896124
141Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.03729485
142Olfactory transduction_Homo sapiens_hsa047400.02857425
143* AMPK signaling pathway_Homo sapiens_hsa041520.02756206
144Insulin signaling pathway_Homo sapiens_hsa04910-0.0086170
145Sulfur relay system_Homo sapiens_hsa04122-0.0015459

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »