LEPROT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: LEPROT is associated with the Golgi complex and endosomes and has a role in cell surface expression of growth hormone receptor (GHR; MIM 600946) and leptin receptor (OBR, or LEPR; MIM 601007), thereby altering receptor-mediated cell signaling (Couturier et al., 2007 [PubMed 18042720]; Touvier et al., 2009 [PubMed 19907080]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)7.05132005
2axon ensheathment in central nervous system (GO:0032291)7.05132005
3fatty acid elongation (GO:0030497)5.52431946
4regulation of integrin-mediated signaling pathway (GO:2001044)5.18727633
5neutrophil activation involved in immune response (GO:0002283)4.89053091
6adhesion of symbiont to host cell (GO:0044650)4.77416693
7virion attachment to host cell (GO:0019062)4.77416693
8ensheathment of neurons (GO:0007272)4.61814863
9axon ensheathment (GO:0008366)4.61814863
10myelination (GO:0042552)4.57744645
11thrombin receptor signaling pathway (GO:0070493)4.52077723
12adhesion of symbiont to host (GO:0044406)4.02527562
13amyloid precursor protein catabolic process (GO:0042987)3.96877854
14response to lipoprotein particle (GO:0055094)3.94091079
15myelin maintenance (GO:0043217)3.88112593
16extracellular fibril organization (GO:0043206)3.82956610
17long-chain fatty acid biosynthetic process (GO:0042759)3.79086361
18negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.73395340
19amyloid precursor protein metabolic process (GO:0042982)3.71008011
20negative regulation of platelet activation (GO:0010544)3.59176155
21regulation of platelet activation (GO:0010543)3.52786030
22angiogenesis involved in wound healing (GO:0060055)3.51382787
23endothelium development (GO:0003158)3.50829300
24leukocyte migration involved in inflammatory response (GO:0002523)3.48976078
25cholesterol biosynthetic process (GO:0006695)3.45367298
26fibril organization (GO:0097435)3.38218863
27regulation of platelet aggregation (GO:0090330)3.37891567
28blood coagulation, intrinsic pathway (GO:0007597)3.36203872
29interleukin-6-mediated signaling pathway (GO:0070102)3.32641495
30platelet degranulation (GO:0002576)3.22409033
31membrane raft organization (GO:0031579)3.19101786
32isoprenoid biosynthetic process (GO:0008299)3.19021723
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.17953571
34positive regulation of monocyte chemotaxis (GO:0090026)3.17097964
35oligodendrocyte differentiation (GO:0048709)3.15880335
36sequestering of extracellular ligand from receptor (GO:0035581)3.15225844
37cellular response to thyroid hormone stimulus (GO:0097067)3.15031471
38regulation of T cell migration (GO:2000404)3.14097796
39import into cell (GO:0098657)3.12379033
40platelet aggregation (GO:0070527)3.12121162
41positive regulation of blood coagulation (GO:0030194)3.11092185
42positive regulation of hemostasis (GO:1900048)3.11092185
43signal peptide processing (GO:0006465)3.07766692
44positive regulation of interleukin-17 production (GO:0032740)3.07355409
45sterol biosynthetic process (GO:0016126)3.00440610
46glycosylceramide metabolic process (GO:0006677)2.99155077
47negative regulation of homotypic cell-cell adhesion (GO:0034111)2.98152600
48negative regulation of protein localization to plasma membrane (GO:1903077)2.97391167
49negative regulation of norepinephrine secretion (GO:0010700)2.96942419
50positive regulation of coagulation (GO:0050820)2.95046311
51regulation of lipoprotein metabolic process (GO:0050746)2.94526272
52regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.94500136
53positive regulation of pseudopodium assembly (GO:0031274)2.93253835
54negative regulation of complement activation (GO:0045916)2.92677470
55triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.92630821
56regulation of macrophage derived foam cell differentiation (GO:0010743)2.91364801
57creatine metabolic process (GO:0006600)2.89729802
58positive regulation of actin filament depolymerization (GO:0030836)2.89442023
59respiratory burst (GO:0045730)2.89108558
60neutrophil activation (GO:0042119)2.88674619
61positive regulation of T cell migration (GO:2000406)2.88223355
62positive regulation of oligodendrocyte differentiation (GO:0048714)2.86321685
63fibrinolysis (GO:0042730)2.86152560
64glomerular filtration (GO:0003094)2.85456572
65negative regulation of neurotransmitter secretion (GO:0046929)2.82351172
66regulation of hemostasis (GO:1900046)2.81990069
67regulation of blood coagulation (GO:0030193)2.81990069
68negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.80813130
69positive regulation of endothelial cell differentiation (GO:0045603)2.80157130
70regulation of collateral sprouting (GO:0048670)2.79271179
71negative regulation of coagulation (GO:0050819)2.79141828
72negative regulation of blood coagulation (GO:0030195)2.78236244
73negative regulation of hemostasis (GO:1900047)2.78236244
74regulation of coagulation (GO:0050818)2.78044339
75positive regulation of receptor recycling (GO:0001921)2.77503257
76response to thyroid hormone (GO:0097066)2.76088123
77GPI anchor biosynthetic process (GO:0006506)2.75853682
78membrane protein ectodomain proteolysis (GO:0006509)2.74953036
79retina vasculature morphogenesis in camera-type eye (GO:0061299)2.74584942
80regulation of metalloenzyme activity (GO:0048552)2.72456963
81negative regulation of protein activation cascade (GO:2000258)2.71967510
82cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.71659103
83regulation of lymphocyte migration (GO:2000401)2.68618268
84low-density lipoprotein particle remodeling (GO:0034374)2.66842891
85positive regulation of vasculogenesis (GO:2001214)2.65704130
86nucleotide transmembrane transport (GO:1901679)2.63936502
87regulation of interleukin-17 production (GO:0032660)2.62700446
88positive regulation of smooth muscle cell migration (GO:0014911)2.60907465
89vesicle fusion (GO:0006906)2.60528328
90intracellular pH reduction (GO:0051452)2.60391720
91granulocyte activation (GO:0036230)2.59634797
92renal filtration (GO:0097205)2.58888051
93definitive hemopoiesis (GO:0060216)2.58604209
94positive regulation of osteoblast proliferation (GO:0033690)2.58437677
95negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.58387024
96astrocyte development (GO:0014002)2.58132153
97negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.57947294
98negative regulation of lipid storage (GO:0010888)2.57639083
99T-helper 1 type immune response (GO:0042088)2.57238630
100positive regulation of lymphocyte migration (GO:2000403)2.54730114
101regulation of monocyte chemotaxis (GO:0090025)2.53823937
102positive regulation of Rho protein signal transduction (GO:0035025)2.52603544
103membrane invagination (GO:0010324)2.51799527
104peptide catabolic process (GO:0043171)2.50042583
105negative regulation of wound healing (GO:0061045)2.50007554
106Rap protein signal transduction (GO:0032486)2.49973116
107regulation of pseudopodium assembly (GO:0031272)2.48415528
108myelination in peripheral nervous system (GO:0022011)2.47362303
109peripheral nervous system axon ensheathment (GO:0032292)2.47362303
110long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.47092359
111positive regulation of endothelial cell apoptotic process (GO:2000353)2.46233525
112positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.46154427
113pH reduction (GO:0045851)2.45676046
114myeloid cell homeostasis (GO:0002262)2.45610052
115sphingosine metabolic process (GO:0006670)2.45431177
116positive regulation by symbiont of host defense response (GO:0052509)2.44397247
117modulation by symbiont of host defense response (GO:0052031)2.44397247
118modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.44397247
119modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.44397247
120positive regulation by organism of defense response of other organism involved in symbiotic interact2.44397247
121modulation by symbiont of host immune response (GO:0052553)2.44397247
122mesodermal cell differentiation (GO:0048333)2.43793621
123eye photoreceptor cell differentiation (GO:0001754)2.43107734
124photoreceptor cell differentiation (GO:0046530)2.43107734
125phagocytosis, engulfment (GO:0006911)2.42921455
126positive regulation of macrophage cytokine production (GO:0060907)2.41115905
127positive regulation of gliogenesis (GO:0014015)2.39368142
128phospholipid homeostasis (GO:0055091)2.39142590
129Leydig cell differentiation (GO:0033327)2.38643120
130cyclooxygenase pathway (GO:0019371)2.38623985
131lung lobe morphogenesis (GO:0060463)2.37914801
132regulation of wound healing (GO:0061041)2.37506328
133peptidyl-tyrosine autophosphorylation (GO:0038083)2.36536398
134positive regulation of wound healing (GO:0090303)2.34729739
135cellular response to vitamin (GO:0071295)2.34233612
136keratan sulfate catabolic process (GO:0042340)2.32999519
137negative regulation of smooth muscle cell migration (GO:0014912)2.32867956
138wound healing, spreading of cells (GO:0044319)2.32715774
139positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.32340940
140substantia nigra development (GO:0021762)2.32057856
141cell adhesion mediated by integrin (GO:0033627)2.32040423
142protein neddylation (GO:0045116)2.30840062
143substrate adhesion-dependent cell spreading (GO:0034446)2.30764265
144regulation of neutrophil migration (GO:1902622)2.30246695
145regulation of neutrophil chemotaxis (GO:0090022)2.30246695
146microglial cell activation (GO:0001774)2.30030742
147positive regulation of glial cell differentiation (GO:0045687)2.28969759
148preassembly of GPI anchor in ER membrane (GO:0016254)2.28226283
149response to hepatocyte growth factor (GO:0035728)2.26894437
150cellular response to hepatocyte growth factor stimulus (GO:0035729)2.26894437
151positive regulation of toll-like receptor signaling pathway (GO:0034123)2.26486280
152collagen fibril organization (GO:0030199)2.26242971
153regulation of dendritic cell antigen processing and presentation (GO:0002604)2.26049182
154GPI anchor metabolic process (GO:0006505)2.25522899
155cellular response to vitamin D (GO:0071305)2.24492876
156positive regulation of transforming growth factor beta production (GO:0071636)2.24473075
157platelet activation (GO:0030168)2.24327289
158positive regulation of chemokine secretion (GO:0090197)2.23915607
159platelet dense granule organization (GO:0060155)2.23651035
160beta-amyloid metabolic process (GO:0050435)2.23119467
161negative regulation of humoral immune response (GO:0002921)2.23072713
162fibroblast migration (GO:0010761)2.22699984
163long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.22677157
164positive regulation of cell junction assembly (GO:1901890)2.22261212
165positive regulation of focal adhesion assembly (GO:0051894)2.22261212
166regulation of endothelial cell differentiation (GO:0045601)2.22259875
167negative regulation of nitric oxide biosynthetic process (GO:0045019)2.22008628
168regulation of homotypic cell-cell adhesion (GO:0034110)2.20964669
169positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.20271666
170negative regulation of adherens junction organization (GO:1903392)2.19336779
171negative regulation of focal adhesion assembly (GO:0051895)2.19336779
172negative regulation of cell junction assembly (GO:1901889)2.19336779
173xenobiotic catabolic process (GO:0042178)2.18565689
174protein localization to cell surface (GO:0034394)2.18478104
175tonic smooth muscle contraction (GO:0014820)2.17923514
176blood vessel maturation (GO:0001955)2.16419432
177regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.16247851
178activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.15656321
179adenosine receptor signaling pathway (GO:0001973)2.12805538
180positive regulation of muscle hypertrophy (GO:0014742)2.10986914
181positive regulation of cardiac muscle hypertrophy (GO:0010613)2.10986914
182relaxation of smooth muscle (GO:0044557)2.10953926
183regulation of Golgi to plasma membrane protein transport (GO:0042996)2.10620519
184regulation of mononuclear cell migration (GO:0071675)2.10453348
185regulation of memory T cell differentiation (GO:0043380)2.08950096
186endodermal cell differentiation (GO:0035987)2.08587515
187cell-matrix adhesion (GO:0007160)2.08562262
188protein carboxylation (GO:0018214)2.07980118
189peptidyl-glutamic acid carboxylation (GO:0017187)2.07980118
190response to magnesium ion (GO:0032026)2.07252485

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.55678545
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.05973678
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.59325486
4TRIM28_21343339_ChIP-Seq_HEK293_Human4.45092468
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.12520976
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.76804067
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.19143759
8GATA1_22025678_ChIP-Seq_K562_Human3.04221363
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.97469750
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.77970689
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.70480520
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.70447252
13WT1_19549856_ChIP-ChIP_CCG9911_Human2.54947742
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.44028972
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.24086420
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.18548414
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.16455862
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.15763776
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.12410303
20* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.04926551
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.04686816
22SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.03066341
23GATA2_21666600_ChIP-Seq_HMVEC_Human2.00454510
24CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.00208671
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.93461549
26SOX2_20726797_ChIP-Seq_SW620_Human1.90948977
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.89733016
28SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.86758576
29NRF2_20460467_ChIP-Seq_MEFs_Mouse1.82817317
30NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.82817317
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.80765599
32CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.78116036
33TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.74200430
34MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.72948616
35* BRD4_25478319_ChIP-Seq_HGPS_Human1.69843727
36ZNF217_24962896_ChIP-Seq_MCF-7_Human1.67434167
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.64913502
38GBX2_23144817_ChIP-Seq_PC3_Human1.64875528
39SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64590043
40CJUN_26792858_Chip-Seq_BT549_Human1.64483646
41* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.56858182
42GATA2_19941826_ChIP-Seq_K562_Human1.54132274
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53225259
44MYB_21317192_ChIP-Seq_ERMYB_Mouse1.53050461
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.52057992
46* LXR_22158963_ChIP-Seq_LIVER_Mouse1.51458096
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49728022
48VDR_24787735_ChIP-Seq_THP-1_Human1.48652754
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45790564
50RUNX_20019798_ChIP-Seq_JUKART_Human1.44290822
51ESR1_20079471_ChIP-ChIP_T-47D_Human1.43261365
52* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.41584973
53GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.41141140
54P63_26484246_Chip-Seq_KERATINOCYTES_Human1.41039314
55STAT4_19710469_ChIP-ChIP_TH1__Mouse1.40985602
56RXR_22158963_ChIP-Seq_LIVER_Mouse1.36235027
57ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.35678852
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32954561
59PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32873228
60* SPI1_23547873_ChIP-Seq_NB4_Human1.32641208
61FOXO3_23340844_ChIP-Seq_DLD1_Human1.27077901
62TP53_16413492_ChIP-PET_HCT116_Human1.25484872
63FOXM1_26456572_ChIP-Seq_MCF-7_Human1.24434415
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24135897
65EGR1_23403033_ChIP-Seq_LIVER_Mouse1.23979132
66PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.23449917
67NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.22981052
68FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21572044
69TP63_23658742_ChIP-Seq_EP156T_Human1.21143275
70CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18526865
71SCL_19346495_ChIP-Seq_HPC-7_Human1.17936542
72JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17660038
73IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17552889
74CDX2_22108803_ChIP-Seq_LS180_Human1.16131736
75PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.15839901
76JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15457420
77SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.14941213
78SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.14941213
79* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.14821641
80* SOX17_20123909_ChIP-Seq_XEN_Mouse1.14706133
81LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14143539
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.13485369
83PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12138956
84CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.11748617
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10871354
86VDR_24763502_ChIP-Seq_THP-1_Human1.09578624
87GATA4_25053715_ChIP-Seq_YYC3_Human1.09335083
88TCF4_18268006_ChIP-ChIP_LS174T_Human1.08127981
89SMAD4_21799915_ChIP-Seq_A2780_Human1.07880165
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07258712
91ESR1_21235772_ChIP-Seq_MCF-7_Human1.06179079
92STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.05070721
93GABP_17652178_ChIP-ChIP_JURKAT_Human1.04870957
94NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.04851570
95NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04673990
96SPI1_23127762_ChIP-Seq_K562_Human1.03893040
97ESR2_21235772_ChIP-Seq_MCF-7_Human1.03784255
98ELK1_19687146_ChIP-ChIP_HELA_Human1.03565525
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03082215
100PPAR_26484153_Chip-Seq_NCI-H1993_Human1.02463889
101CLOCK_20551151_ChIP-Seq_293T_Human1.01403611
102CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99406637
103GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99337166
104SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99308036
105ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99072020
106SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98913918
107RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98569703
108OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97634937
109CRX_20693478_ChIP-Seq_RETINA_Mouse0.97208003
110STAT1_20625510_ChIP-Seq_HELA_Human0.97007846
111FLI1_27457419_Chip-Seq_LIVER_Mouse0.96769146
112NANOG_18555785_Chip-Seq_ESCs_Mouse0.96762186
113CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96382908
114EP300_21415370_ChIP-Seq_HL-1_Mouse0.96317319
115P53_22387025_ChIP-Seq_ESCs_Mouse0.95976736
116ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95441492
117TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94974655
118EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94536423
119* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.94403865
120AHR_22903824_ChIP-Seq_MCF-7_Human0.93932509
121PU_27001747_Chip-Seq_BMDM_Mouse0.93406090
122E2F1_18555785_Chip-Seq_ESCs_Mouse0.93110781
123EOMES_21245162_ChIP-Seq_HESCs_Human0.93035800
124ARNT_22903824_ChIP-Seq_MCF-7_Human0.92924741
125* P300_19829295_ChIP-Seq_ESCs_Human0.92867703
126CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90906637
127BCAT_22108803_ChIP-Seq_LS180_Human0.89811853
128ELK1_22589737_ChIP-Seq_MCF10A_Human0.89500057
129ELF1_17652178_ChIP-ChIP_JURKAT_Human0.89106056
130KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.89105398
131KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.89105398
132KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.89105398
133CMYC_18555785_Chip-Seq_ESCs_Mouse0.88095387
134RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.87950633
135BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87795817
136CREB1_15753290_ChIP-ChIP_HEK293T_Human0.87654486
137PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87455738
138VDR_22108803_ChIP-Seq_LS180_Human0.87265167
139* GATA1_19941826_ChIP-Seq_K562_Human0.86177678
140EGR1_19032775_ChIP-ChIP_M12_Human0.86130945
141TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83912050
142SMC1_22415368_ChIP-Seq_MEFs_Mouse0.83815006
143ELK3_25401928_ChIP-Seq_HUVEC_Human0.83484054
144TP53_18474530_ChIP-ChIP_U2OS_Human0.79823623
145MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.77909818
146CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77624495
147SRF_21415370_ChIP-Seq_HL-1_Mouse0.77414501
148BRD4_27068464_Chip-Seq_AML-cells_Mouse0.77274481
149HOXB4_20404135_ChIP-ChIP_EML_Mouse0.76845041
150SA1_22415368_ChIP-Seq_MEFs_Mouse0.76278860
151MYB_26560356_Chip-Seq_TH2_Human0.74541899

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.86378588
2MP0000920_abnormal_myelination3.94915302
3MP0005058_abnormal_lysosome_morphology3.01807085
4MP0003950_abnormal_plasma_membrane2.98289117
5MP0008004_abnormal_stomach_pH2.91111684
6MP0003724_increased_susceptibility_to2.89852481
7MP0005171_absent_coat_pigmentation2.82802612
8MP0003690_abnormal_glial_cell2.67660847
9MP0006082_CNS_inflammation2.59049424
10MP0004272_abnormal_basement_membrane2.57290929
11MP0002148_abnormal_hypersensitivity_rea2.38318448
12MP0005275_abnormal_skin_tensile2.26391681
13MP0001835_abnormal_antigen_presentation2.19077232
14MP0006054_spinal_hemorrhage2.12305295
15MP0002419_abnormal_innate_immunity2.10288985
16MP0005503_abnormal_tendon_morphology2.05735508
17MP0009785_altered_susceptibility_to1.98989872
18MP0001958_emphysema1.90638845
19MP0001533_abnormal_skeleton_physiology1.87798384
20MP0004147_increased_porphyrin_level1.86532491
21MP0005000_abnormal_immune_tolerance1.79909407
22MP0001879_abnormal_lymphatic_vessel1.78298700
23MP0002295_abnormal_pulmonary_circulatio1.78269583
24MP0002933_joint_inflammation1.73489231
25MP0008775_abnormal_heart_ventricle1.73292490
26MP0001542_abnormal_bone_strength1.70347574
27MP0003436_decreased_susceptibility_to1.69450981
28MP0003300_gastrointestinal_ulcer1.66891241
29MP0004084_abnormal_cardiac_muscle1.65085521
30MP0010386_abnormal_urinary_bladder1.61310042
31MP0005025_abnormal_response_to1.60593475
32MP0000343_altered_response_to1.60083658
33MP0000230_abnormal_systemic_arterial1.57595250
34MP0005397_hematopoietic_system_phenotyp1.52983387
35MP0001545_abnormal_hematopoietic_system1.52983387
36MP0003279_aneurysm1.52833636
37MP0000685_abnormal_immune_system1.49046707
38MP0003634_abnormal_glial_cell1.47666324
39MP0004510_myositis1.46755266
40MP0009780_abnormal_chondrocyte_physiolo1.45564289
41MP0000465_gastrointestinal_hemorrhage1.45532788
42MP0005387_immune_system_phenotype1.42645430
43MP0001790_abnormal_immune_system1.42645430
44MP0005164_abnormal_response_to1.42312372
45MP0005595_abnormal_vascular_smooth1.42117916
46MP0003136_yellow_coat_color1.40565991
47MP0005623_abnormal_meninges_morphology1.40314200
48MP0008260_abnormal_autophagy1.39758542
49MP0009333_abnormal_splenocyte_physiolog1.38685002
50MP0003656_abnormal_erythrocyte_physiolo1.38475665
51MP0002452_abnormal_antigen_presenting1.37961002
52MP0003191_abnormal_cellular_cholesterol1.37591616
53MP0005408_hypopigmentation1.36951213
54MP0001851_eye_inflammation1.33970495
55MP0005390_skeleton_phenotype1.32218418
56MP0004134_abnormal_chest_morphology1.27529725
57MP0010368_abnormal_lymphatic_system1.24813319
58MP0005451_abnormal_body_composition1.24535050
59MP0009384_cardiac_valve_regurgitation1.24313505
60MP0010329_abnormal_lipoprotein_level1.21476229
61MP0001756_abnormal_urination1.20974709
62MP0003448_altered_tumor_morphology1.20622679
63MP0002723_abnormal_immune_serum1.20476117
64MP0002998_abnormal_bone_remodeling1.20204508
65MP0002132_abnormal_respiratory_system1.18811694
66MP0000383_abnormal_hair_follicle1.16273020
67MP0003252_abnormal_bile_duct1.15910624
68MP0003186_abnormal_redox_activity1.13673246
69MP0001346_abnormal_lacrimal_gland1.13372029
70MP0002139_abnormal_hepatobiliary_system1.13238946
71MP0005083_abnormal_biliary_tract1.12631025
72MP0005671_abnormal_response_to1.12360188
73MP0002420_abnormal_adaptive_immunity1.11924604
74MP0003303_peritoneal_inflammation1.11882104
75MP0001819_abnormal_immune_cell1.11643158
76MP0003806_abnormal_nucleotide_metabolis1.10308818
77MP0003566_abnormal_cell_adhesion1.10150615
78MP0005508_abnormal_skeleton_morphology1.10047604
79MP0010678_abnormal_skin_adnexa1.09926168
80MP0004484_altered_response_of1.09504499
81MP0000767_abnormal_smooth_muscle1.08050982
82MP0005085_abnormal_gallbladder_physiolo1.06130637
83MP0006138_congestive_heart_failure1.05637062
84MP0001661_extended_life_span1.05357240
85MP0001243_abnormal_dermal_layer1.03590118
86MP0005084_abnormal_gallbladder_morpholo1.03551358
87MP0003172_abnormal_lysosome_physiology1.02903472
88MP0003632_abnormal_nervous_system1.02553352
89MP0000604_amyloidosis1.01960276
90MP0009840_abnormal_foam_cell1.00754010
91MP0004381_abnormal_hair_follicle1.00523329
92MP0002128_abnormal_blood_circulation1.00117811
93MP0003075_altered_response_to0.99837284
94MP0005365_abnormal_bile_salt0.99304642
95MP0004036_abnormal_muscle_relaxation0.98995401
96MP0002405_respiratory_system_inflammati0.97762761
97MP0004782_abnormal_surfactant_physiolog0.94865374
98MP0002972_abnormal_cardiac_muscle0.93734770
99MP0002896_abnormal_bone_mineralization0.93322277
100MP0005167_abnormal_blood-brain_barrier0.93158584
101MP0003638_abnormal_response/metabolism_0.91527589
102MP0001800_abnormal_humoral_immune0.91033306
103MP0003195_calcinosis0.90073015
104MP0001905_abnormal_dopamine_level0.88584720
105MP0003453_abnormal_keratinocyte_physiol0.87924192
106MP0004947_skin_inflammation0.87512346
107MP0004215_abnormal_myocardial_fiber0.86854342
108MP0004883_abnormal_blood_vessel0.86588856
109MP0009763_increased_sensitivity_to0.86225001
110MP0001544_abnormal_cardiovascular_syste0.84900636
111MP0005385_cardiovascular_system_phenoty0.84900636
112MP0003091_abnormal_cell_migration0.84809281
113MP0002971_abnormal_brown_adipose0.83563941
114MP0002168_other_aberrant_phenotype0.82660055
115MP0000013_abnormal_adipose_tissue0.82476500
116MP0008875_abnormal_xenobiotic_pharmacok0.81612445
117MP0002060_abnormal_skin_morphology0.79899442
118MP0000733_abnormal_muscle_development0.79331701
119MP0003795_abnormal_bone_structure0.78675433
120MP0009643_abnormal_urine_homeostasis0.78613152
121MP0001845_abnormal_inflammatory_respons0.78320982
122MP0005464_abnormal_platelet_physiology0.78080660
123MP0004742_abnormal_vestibular_system0.77308015
124MP0005388_respiratory_system_phenotype0.77118427
125MP0002133_abnormal_respiratory_system0.77118427
126MP0000858_altered_metastatic_potential0.77009037
127MP0005360_urolithiasis0.76870366
128MP0001915_intracranial_hemorrhage0.75672173
129MP0003705_abnormal_hypodermis_morpholog0.75619724
130MP0003828_pulmonary_edema0.75446431
131MP0000249_abnormal_blood_vessel0.75117094
132MP0008469_abnormal_protein_level0.74446177
133MP0002118_abnormal_lipid_homeostasis0.74201455
134MP0005257_abnormal_intraocular_pressure0.74131350
135MP0005620_abnormal_muscle_contractility0.74069293
136MP0004130_abnormal_muscle_cell0.72510790
137MP0005310_abnormal_salivary_gland0.72133976
138MP0000372_irregular_coat_pigmentation0.71345178
139MP0009764_decreased_sensitivity_to0.71249756
140MP0003329_amyloid_beta_deposits0.71226159
141MP0005165_increased_susceptibility_to0.71192302
142MP0005023_abnormal_wound_healing0.70902426
143MP0000647_abnormal_sebaceous_gland0.70401592
144MP0005367_renal/urinary_system_phenotyp0.70287367
145MP0000516_abnormal_urinary_system0.70287367
146MP0001614_abnormal_blood_vessel0.70002043
147MP0010352_gastrointestinal_tract_polyps0.66793130
148MP0002108_abnormal_muscle_morphology0.63901816
149MP0005332_abnormal_amino_acid0.63880845

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)6.62845252
2Increased mean platelet volume (HP:0011877)6.08340057
3Menorrhagia (HP:0000132)5.95480169
4Abnormal platelet volume (HP:0011876)5.55933823
5Vacuolated lymphocytes (HP:0001922)4.97016329
6Epistaxis (HP:0000421)4.67505593
7Parakeratosis (HP:0001036)4.51635006
8Gingival bleeding (HP:0000225)4.35339596
9Impaired platelet aggregation (HP:0003540)4.29535887
10Abnormal platelet function (HP:0011869)4.29535887
11Aortic aneurysm (HP:0004942)4.12991532
12Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.04061093
13Neurofibrillary tangles (HP:0002185)3.99178615
14Increased neuronal autofluorescent lipopigment (HP:0002074)3.94166878
15Abnormality of macrophages (HP:0004311)3.77146495
16Protrusio acetabuli (HP:0003179)3.73824505
17Increased cerebral lipofuscin (HP:0011813)3.69557684
18Premature rupture of membranes (HP:0001788)3.60634080
19Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.59529210
20Recurrent abscess formation (HP:0002722)3.53461269
21Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.39573561
22Degeneration of the lateral corticospinal tracts (HP:0002314)3.39573561
23Hepatosplenomegaly (HP:0001433)3.32966544
24Hyperlipoproteinemia (HP:0010980)3.27579380
25Polycythemia (HP:0001901)3.24628899
26Conjunctival telangiectasia (HP:0000524)3.15416954
27Sensory axonal neuropathy (HP:0003390)3.10286542
28Congenital ichthyosiform erythroderma (HP:0007431)3.09939527
29Patchy hypopigmentation of hair (HP:0011365)3.09618032
30Axonal loss (HP:0003447)3.09524374
31Mitral stenosis (HP:0001718)3.08990213
32Acanthocytosis (HP:0001927)3.01939602
33Abnormality of the vasculature of the conjunctiva (HP:0008054)3.01489689
34Recurrent bacterial skin infections (HP:0005406)3.01351434
35Bruising susceptibility (HP:0000978)2.95904746
36Poikilocytosis (HP:0004447)2.90191446
37Spondylolisthesis (HP:0003302)2.89156606
38Osteolytic defects of the hand bones (HP:0009699)2.89086607
39Osteolytic defects of the phalanges of the hand (HP:0009771)2.89086607
40Systemic lupus erythematosus (HP:0002725)2.83137981
41Abnormality of the common coagulation pathway (HP:0010990)2.82884336
42White forelock (HP:0002211)2.80953094
43Cardiovascular calcification (HP:0011915)2.75915200
44Eczematoid dermatitis (HP:0000976)2.73130765
45Abnormality of the heme biosynthetic pathway (HP:0010472)2.68572503
46Myocardial infarction (HP:0001658)2.64846044
47Stridor (HP:0010307)2.60900523
48Segmental peripheral demyelination/remyelination (HP:0003481)2.57393840
49Purpura (HP:0000979)2.55371539
50Prolonged neonatal jaundice (HP:0006579)2.50189664
51Hypoplasia of the iris (HP:0007676)2.49508654
52Abnormality of glycolipid metabolism (HP:0010969)2.46121932
53Abnormality of liposaccharide metabolism (HP:0010968)2.46121932
54Abnormality of glycosphingolipid metabolism (HP:0004343)2.46121932
55Premature skin wrinkling (HP:0100678)2.45438573
56Pulmonary artery stenosis (HP:0004415)2.43043150
57Peripheral hypomyelination (HP:0007182)2.42962339
58Vascular calcification (HP:0004934)2.40353444
59Complement deficiency (HP:0004431)2.37037591
60Xanthomatosis (HP:0000991)2.36514062
61Recurrent skin infections (HP:0001581)2.32568486
62Dysostosis multiplex (HP:0000943)2.32175642
63Abnormality of the phalanges of the 2nd finger (HP:0009541)2.31591508
64Renal Fanconi syndrome (HP:0001994)2.28127267
65Cerebral hypomyelination (HP:0006808)2.26663870
66Abnormality of mucopolysaccharide metabolism (HP:0011020)2.22997614
67Abnormality of polysaccharide metabolism (HP:0011012)2.22997614
68Abnormality of glycosaminoglycan metabolism (HP:0004371)2.22997614
69Dilatation of the ascending aorta (HP:0005111)2.21945983
70Elevated erythrocyte sedimentation rate (HP:0003565)2.21532882
71Increased serum pyruvate (HP:0003542)2.20734231
72Abnormality of glycolysis (HP:0004366)2.20734231
73Joint hemorrhage (HP:0005261)2.20094725
74Loss of speech (HP:0002371)2.19465198
75Metaphyseal dysplasia (HP:0100255)2.18715488
76Cerebral hemorrhage (HP:0001342)2.17790469
77Cerebral inclusion bodies (HP:0100314)2.17070742
78Aortic dissection (HP:0002647)2.11754813
79Partial duplication of the phalanx of hand (HP:0009999)2.08145872
80Spastic paraparesis (HP:0002313)2.08081609
81Short hallux (HP:0010109)2.05217141
82Progressive neurologic deterioration (HP:0002344)2.04538612
83Stenosis of the external auditory canal (HP:0000402)2.02554706
84Broad metatarsal (HP:0001783)2.02183079
85Onion bulb formation (HP:0003383)2.02004734
86Generalized aminoaciduria (HP:0002909)2.01631229
87Wormian bones (HP:0002645)2.00940888
88Chronic otitis media (HP:0000389)1.99959035
89Partial duplication of thumb phalanx (HP:0009944)1.99659618
90Abnormality of complement system (HP:0005339)1.98701828
91Short middle phalanx of the 5th finger (HP:0004220)1.97770301
92Beaking of vertebral bodies (HP:0004568)1.96851969
93Vascular tortuosity (HP:0004948)1.94996632
94Autoamputation (HP:0001218)1.94957381
95Cellulitis (HP:0100658)1.94932080
96Abnormal auditory evoked potentials (HP:0006958)1.94314605
97Dyschromatopsia (HP:0007641)1.92851900
98Abnormality of iron homeostasis (HP:0011031)1.92725466
99Arterial tortuosity (HP:0005116)1.92635246
100Mucosal telangiectasiae (HP:0100579)1.91052295
101Ankle contracture (HP:0006466)1.90921500
102Blue sclerae (HP:0000592)1.90698507
103Abnormality of the 2nd finger (HP:0004100)1.90625018
104Thick nail (HP:0001805)1.90166880
105Abnormality of dentin (HP:0010299)1.87906865
106Gastrointestinal stroma tumor (HP:0100723)1.87333045
107Vertebral compression fractures (HP:0002953)1.86764274
108Follicular hyperkeratosis (HP:0007502)1.86659387
109Fused cervical vertebrae (HP:0002949)1.86387292
110Abnormal pupillary function (HP:0007686)1.86322735
111Soft skin (HP:0000977)1.86092654
112Petechiae (HP:0000967)1.85682109
113Leukodystrophy (HP:0002415)1.85478325
114Aplasia/Hypoplasia of the hallux (HP:0008362)1.84654784
115Abnormal delivery (HP:0001787)1.84361975
116Paralysis (HP:0003470)1.83469139
117Peritonitis (HP:0002586)1.83348610
118Cervical subluxation (HP:0003308)1.82972050
119Glomerulonephritis (HP:0000099)1.82936159
120Abnormality of proline metabolism (HP:0010907)1.81952196
121Hydroxyprolinuria (HP:0003080)1.81952196
1223-Methylglutaconic aciduria (HP:0003535)1.81694733
123Venous insufficiency (HP:0005293)1.79628123
124Ovoid vertebral bodies (HP:0003300)1.79180023
125Abnormality of transition element cation homeostasis (HP:0011030)1.78987800
126Abnormality of renal resorption (HP:0011038)1.78825875
127Striae distensae (HP:0001065)1.76494876
128Abnormality of the acetabulum (HP:0003170)1.76046463
129Hypoplasia of the odontoid process (HP:0003311)1.75483424
130Adrenal hypoplasia (HP:0000835)1.74067406
131Poor head control (HP:0002421)1.72776903
132Alacrima (HP:0000522)1.72524733
133Aneurysm (HP:0002617)1.72428546
134Abnormal hemoglobin (HP:0011902)1.71809127
135Tetraparesis (HP:0002273)1.71807782
136Abnormality of the middle phalanges of the toes (HP:0010183)1.71659922
137Chondrocalcinosis (HP:0000934)1.71505827
138Abnormal umbilical cord blood vessels (HP:0011403)1.71371791
139Single umbilical artery (HP:0001195)1.71371791
140Abnormality of the fetal cardiovascular system (HP:0010948)1.71371791
141Chronic obstructive pulmonary disease (HP:0006510)1.71335448
142Obstructive lung disease (HP:0006536)1.71335448
143Increased variability in muscle fiber diameter (HP:0003557)1.71223205
144Urinary glycosaminoglycan excretion (HP:0003541)1.70724355
145Mucopolysacchariduria (HP:0008155)1.70724355
146Nonimmune hydrops fetalis (HP:0001790)1.69842283
147Abnormality of Sharpey fibers (HP:0100685)1.68779717
148Nausea (HP:0002018)1.66364454
149Joint stiffness (HP:0001387)1.65935549
150Ileus (HP:0002595)1.65703512
151Venous abnormality (HP:0002624)1.64755112
152Corneal dystrophy (HP:0001131)1.63880416
153Stomach cancer (HP:0012126)1.63811596
154Hematochezia (HP:0002573)1.63627450
155Joint swelling (HP:0001386)1.63454062
156Supranuclear gaze palsy (HP:0000605)1.63318931
157Scapular winging (HP:0003691)1.62820532
158Spontaneous hematomas (HP:0007420)1.62678132
159Fragile skin (HP:0001030)1.62277879
160Nephritis (HP:0000123)1.62196080
161Atrophic scars (HP:0001075)1.61258107
162Anhidrosis (HP:0000970)1.61052673
163Spontaneous abortion (HP:0005268)1.60672850
164Skin nodule (HP:0200036)1.60131928
165Basal ganglia calcification (HP:0002135)1.59946063
166Bone cyst (HP:0012062)1.59867521
167Episodic fever (HP:0001954)1.59658834
168Spinal rigidity (HP:0003306)1.59021550

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.59152194
2PBK3.93545125
3EPHB13.57522972
4MST43.41706005
5OXSR13.23320025
6MET2.53369823
7BLK2.35096847
8LIMK12.15559288
9BCR2.14873765
10TIE12.14706177
11MAPKAPK52.00056411
12TGFBR21.97606668
13IRAK41.85447347
14TAOK31.83233390
15ACVR1B1.81581916
16FRK1.74937398
17EIF2AK11.70563133
18CDK191.65208674
19STK31.61731143
20MAP3K121.61334671
21CLK11.61218249
22NEK61.60773031
23EPHA31.58152817
24TRPM71.57483145
25FER1.55991760
26MAPKAPK31.54193772
27WNK41.52984782
28STK101.52909351
29ZAP701.52684370
30MAP3K141.49243858
31PKN11.48127497
32MAP3K61.44439968
33NME21.42893782
34FGFR21.41596223
35KDR1.38374169
36BMPR1B1.37389500
37ADRBK11.36960356
38LRRK21.36855230
39PDGFRA1.34080842
40PRPF4B1.32380440
41LATS11.30802536
42TYK21.29400694
43PIM21.26654634
44TBK11.24293398
45IKBKB1.22839232
46RIPK41.22421079
47TESK21.19906973
48KIT1.19841565
49MYLK1.19591302
50PAK21.15910955
51JAK11.15360868
52CSNK1G31.13829628
53FLT31.12348399
54CSNK1A1L1.11372926
55ROCK21.09973304
56ERN11.09251176
57AKT31.02295090
58MAP2K31.01476331
59WNK10.99883842
60MOS0.98620905
61FGR0.97692930
62TESK10.95614218
63MAP2K20.95418540
64CSNK1G10.94831575
65GRK50.92975284
66STK240.92966435
67MAP4K10.91183255
68ABL20.89626759
69MAP3K20.88600007
70BMPR20.86304539
71MKNK10.85961450
72RPS6KA50.82982750
73MAP3K30.82760783
74CSF1R0.82432304
75PRKG20.82096912
76MAP2K10.80796099
77IKBKE0.80259670
78TNIK0.79859802
79PRKCE0.79752744
80ITK0.78780455
81PLK20.77246159
82EPHB20.77046739
83MATK0.76875686
84PTK20.76132644
85CSK0.75353131
86DYRK20.75048333
87NEK90.74719034
88PRKCQ0.74418974
89GRK70.72757323
90FGFR30.71355329
91NLK0.70777029
92LCK0.66201098
93INSRR0.65839164
94ROCK10.65405913
95DMPK0.65385077
96LYN0.64500360
97PIK3CG0.64471416
98CAMKK20.63244537
99PINK10.63005213
100SYK0.62780024
101MUSK0.62541477
102MAP3K50.61462943
103MAPK70.61368468
104IRAK20.60066983
105PAK10.59899624
106HCK0.59667446
107IRAK30.57876411
108MAPKAPK20.57379825
109RET0.57321340
110LMTK20.55956228
111BMX0.55906581
112DAPK30.55546899
113ABL10.54672372
114IRAK10.54541537
115BRSK20.53902901
116STK40.53542279
117PAK40.52957718
118PAK30.52670015
119PRKD20.51545958
120STK38L0.51391859
121ADRBK20.50854663
122IGF1R0.50683282
123GRK10.50331789
124BTK0.49893131
125MAP4K20.49562970
126WNK30.49528738
127ERBB30.48921478
128TEC0.48808979
129GSK3A0.48568692
130DDR20.48343794
131TXK0.48314373
132FYN0.47539447
133JAK30.47471107
134NUAK10.47213684
135ERBB40.47052265
136PRKACG0.46809702
137CAMK2B0.46337664
138ILK0.45208991
139PRKD10.44868909
140EGFR0.44830299
141MAPK150.44466909
142MST1R0.43324919
143TGFBR10.43269198
144PDGFRB0.42852983
145NTRK10.42427467
146INSR0.42059720
147CSNK1G20.40778061
148CAMK2D0.40225417
149PTK2B0.39394237
150PRKCD0.37069700
151PDK20.36974611
152PIK3CA0.36810503

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.56499920
2Steroid biosynthesis_Homo sapiens_hsa001003.37821931
3Fatty acid elongation_Homo sapiens_hsa000622.88765696
4Protein export_Homo sapiens_hsa030602.74822211
5Complement and coagulation cascades_Homo sapiens_hsa046102.51674064
6Lysosome_Homo sapiens_hsa041422.28412727
7Sphingolipid metabolism_Homo sapiens_hsa006002.21921119
8Ether lipid metabolism_Homo sapiens_hsa005652.21912425
9Malaria_Homo sapiens_hsa051442.17087056
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.14340338
11Other glycan degradation_Homo sapiens_hsa005112.11787767
12Rheumatoid arthritis_Homo sapiens_hsa053232.02954661
13Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.89336245
14Phagosome_Homo sapiens_hsa041451.72065030
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71978739
16Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.70444189
17Oxidative phosphorylation_Homo sapiens_hsa001901.65511254
18Pertussis_Homo sapiens_hsa051331.64490395
19Leishmaniasis_Homo sapiens_hsa051401.63765737
20Nitrogen metabolism_Homo sapiens_hsa009101.60145853
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.58891791
22Staphylococcus aureus infection_Homo sapiens_hsa051501.56022250
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.54543958
24Proteasome_Homo sapiens_hsa030501.50047224
25Chemical carcinogenesis_Homo sapiens_hsa052041.48291180
26ECM-receptor interaction_Homo sapiens_hsa045121.47497738
27Sulfur metabolism_Homo sapiens_hsa009201.43991829
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.43146427
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.42348116
30Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.41807650
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38478393
32Graft-versus-host disease_Homo sapiens_hsa053321.38354586
33Arachidonic acid metabolism_Homo sapiens_hsa005901.37960097
34PPAR signaling pathway_Homo sapiens_hsa033201.36581939
35Glutathione metabolism_Homo sapiens_hsa004801.25534077
36Shigellosis_Homo sapiens_hsa051311.24826312
37Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.24210611
38Pentose and glucuronate interconversions_Homo sapiens_hsa000401.24099251
39Vascular smooth muscle contraction_Homo sapiens_hsa042701.23935890
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.22846740
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.22230596
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.21026874
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.20720922
44Salmonella infection_Homo sapiens_hsa051321.20347817
45Ribosome_Homo sapiens_hsa030101.15583044
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.15123736
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.15077876
48Autoimmune thyroid disease_Homo sapiens_hsa053201.14539721
49NF-kappa B signaling pathway_Homo sapiens_hsa040641.14150997
50Legionellosis_Homo sapiens_hsa051341.12202303
51Parkinsons disease_Homo sapiens_hsa050121.11790012
52Hematopoietic cell lineage_Homo sapiens_hsa046401.10367214
53Linoleic acid metabolism_Homo sapiens_hsa005911.09589445
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.05848117
55Allograft rejection_Homo sapiens_hsa053301.04297305
56Osteoclast differentiation_Homo sapiens_hsa043801.03748218
57Retinol metabolism_Homo sapiens_hsa008301.02982064
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.01982800
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01011325
60Toll-like receptor signaling pathway_Homo sapiens_hsa046201.00124858
61Tuberculosis_Homo sapiens_hsa051521.00060640
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.98966568
63Starch and sucrose metabolism_Homo sapiens_hsa005000.98545678
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.97953251
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95372855
66Vibrio cholerae infection_Homo sapiens_hsa051100.94659632
67Asthma_Homo sapiens_hsa053100.92791915
68Fatty acid degradation_Homo sapiens_hsa000710.92765850
69Dilated cardiomyopathy_Homo sapiens_hsa054140.91151922
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.90682883
71Glycerolipid metabolism_Homo sapiens_hsa005610.88110947
72Alzheimers disease_Homo sapiens_hsa050100.87699710
73Toxoplasmosis_Homo sapiens_hsa051450.84253070
74Histidine metabolism_Homo sapiens_hsa003400.81491457
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.80584521
76Fat digestion and absorption_Homo sapiens_hsa049750.79942437
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78607225
78Pancreatic secretion_Homo sapiens_hsa049720.77974589
79Focal adhesion_Homo sapiens_hsa045100.77617033
80Viral myocarditis_Homo sapiens_hsa054160.77606026
81Renal cell carcinoma_Homo sapiens_hsa052110.76269640
82Axon guidance_Homo sapiens_hsa043600.74641383
83Endocytosis_Homo sapiens_hsa041440.74405954
84Gap junction_Homo sapiens_hsa045400.73773899
85Apoptosis_Homo sapiens_hsa042100.73678021
86Tyrosine metabolism_Homo sapiens_hsa003500.73371067
87ABC transporters_Homo sapiens_hsa020100.73368603
88Amoebiasis_Homo sapiens_hsa051460.71580170
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70315276
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70203686
91Renin secretion_Homo sapiens_hsa049240.69707602
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67619027
93Measles_Homo sapiens_hsa051620.66320485
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66121802
95Chemokine signaling pathway_Homo sapiens_hsa040620.65285602
96Tight junction_Homo sapiens_hsa045300.65009617
97Antigen processing and presentation_Homo sapiens_hsa046120.64509405
98B cell receptor signaling pathway_Homo sapiens_hsa046620.64148536
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62461898
100TNF signaling pathway_Homo sapiens_hsa046680.61958911
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60717967
102Serotonergic synapse_Homo sapiens_hsa047260.60603167
103Tryptophan metabolism_Homo sapiens_hsa003800.60071240
104African trypanosomiasis_Homo sapiens_hsa051430.59707252
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59668689
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56835233
107TGF-beta signaling pathway_Homo sapiens_hsa043500.56595451
108Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56567006
109Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55596711
110Intestinal immune network for IgA production_Homo sapiens_hsa046720.55534497
111Circadian rhythm_Homo sapiens_hsa047100.54680736
112Dorso-ventral axis formation_Homo sapiens_hsa043200.54056251
113Platelet activation_Homo sapiens_hsa046110.53789182
114Mineral absorption_Homo sapiens_hsa049780.53714350
115Proteoglycans in cancer_Homo sapiens_hsa052050.52613590
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.52286501
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50651282
118Huntingtons disease_Homo sapiens_hsa050160.48180074
119RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47935228
120Hepatitis C_Homo sapiens_hsa051600.47472664
121beta-Alanine metabolism_Homo sapiens_hsa004100.45870058
122Prion diseases_Homo sapiens_hsa050200.45502569
123Collecting duct acid secretion_Homo sapiens_hsa049660.45142235
124Peroxisome_Homo sapiens_hsa041460.44837528
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.44309209
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.44273398
127Melanoma_Homo sapiens_hsa052180.44248285
128Ras signaling pathway_Homo sapiens_hsa040140.43736128
129Small cell lung cancer_Homo sapiens_hsa052220.43733168
130Pancreatic cancer_Homo sapiens_hsa052120.42804382
131Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42054138
132Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41399706
133Arginine and proline metabolism_Homo sapiens_hsa003300.39981339
134RNA polymerase_Homo sapiens_hsa030200.39772998
135Rap1 signaling pathway_Homo sapiens_hsa040150.38749560
136Renin-angiotensin system_Homo sapiens_hsa046140.36808264
137Ovarian steroidogenesis_Homo sapiens_hsa049130.34704179
138Protein digestion and absorption_Homo sapiens_hsa049740.32432669
139Herpes simplex infection_Homo sapiens_hsa051680.31957742
140Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30895591
141Prostate cancer_Homo sapiens_hsa052150.30738580

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